NS LS HS/NK NS LS HS/LK LS HS/NK NS LS HS/LK NS - PLOS

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Page 1. Telemetric recordings. B. Mo d ifie d. Light/D a rk cycle co h o rts. C57BL/6N. C57BL/6J. 6. 7. NIBP. Blood collec on. 8. -1. 0. 1. 2. 3. Surgery. NIBP. NIBP.
A. Standard Light/Dark cycle cohorts B. Modified Light/Dark cycle cohorts C. Light/Dark cycle

Telemetric recordings Blood collec2on

C57BL/6N Surgery 0

-1

1

NS

C57BL/6J

2

5

4

3

LS

HS/NK Blood collec2on

Surgery -1

0

1

NS

2

LS

5

4

3

HS/LK Telemetric recordings

C57BL/6N

Surgery

NIBP 0

-1

NIBP 2

1

3

Surgery -1

1

2

3

7

6

8

HS/LK

24h00

12h00 07h00

19h00

07h00

5

4

LS

12h00

8

Blood NIBP collec2on

NIBP

NS 24h00

7

6

HS/NK

NIBP 0

5

4

LS

NS C57BL/6J

Blood NIBP collec2on

24h00 19h00

Standard Light/ Dark cycle 11h00

23h00

Modiļ¬ed Light/ Dark cycle

11h00

23h00