Aug 8, 1996 - Nutritional status of children with acute lymphoblastic leukemia: a ..... midnight the day before, and having recorded their food and drink.
Nutritional leukemia:
status of children with acute a longitudinal study13
Laure Delbecque-Boussard, Philippe Vic, Jean Pierre
ABSTRACT acute
To
were
the
nutritional
consequences
its treatment,
15 children
leukemia
were
impedance,
Gottrand, Simon Ategbo, and Dominique Turck
evaluate
lymphoblastic
leukemia
Frederic Farriaux,
studied.
energy
and
Anthropometric
intake,
determined
and
resting
at diagnosis
fat-free
data,
energy
and on days
three
18 y, previous
or
nutritional
nutritional
with (ALL; ±
chesupport,
status,
and
Research
refusal to participate in the study. All children were according to the 58881 European Organization for and Treatment of Cancer trial (13), as detailed in
Figure
1. Fifteen
SD: 6.8
control The
±
subjects. protocol
University
in children
(4,
during
Exclusion
chronic
mecha-
the first assessment
y).
motherapy
composition.
with caused
immunity, survival
Between August 1994 and newly diagnosed low-risk acute
From
healthy children (age 3. 1 y) matched for sex was
Hospital
the Pediatric
2
of Pediatrics, Supported by a grant
3
Address
approved
by
of Lille,
France.
Oncology,
Department
low concentrations and
improve
cancer
AND
was
recall
problems
and abnormally
the
ie,
inter-
Patients
I
Malnutrition
cell-mediated
may
evolution
SUBJECTS
INTRODUCTION
cancer.
y (IFN-y),
itself,
(TNF),
treatment.
±
status,
factor
was
l997;65:95-l00.
nutritional
interferon
restore
with
there
No indication
IL-6,
itself
expenditure
of the disease
necrosis
was to determine the nutritional status expenditure (REE) of children at diagnosis
to be an adaptative
intake.
effects
of tumor
energy
study
the first month
as a group was evident during further long-term nutritional
increased
by side
disease
Most of these studies have only focused on anthropomethc data (9, 10) and there are few reports of the energy expenditure
of
body
side
the
infections (5). Moreover, several studies of adult patients have suggested that adequate nutritional support during chemotherapy could prevent weight loss, lead to better tolerance of
at the time
by the parents’
in
1 (IL-l),
to
of children
in patients
of chemotherapy
seemed
Children,
WORDS
showed
due
are caused
and/or
compaThis
remained
be
concentrations
leukin
which
± 19%)
Energy the
(RQ)
of consequences
carbohydrate
trition in the patients of treatment although needed.
results
period
in RQ
(104 but was
± 48%).
Cytokines
as shown
and the absence
transient
nism
71. The
intake for age
also
intakes, chemotherapy
by the cachectic
status
energy values
protein with
may
and
h) and day 71 (4844.7 ± (43 1 3.8 ± 823.5 kJ/24
REE. The poor intakes
were
responses
different.
1, 36, and
elevated
subjects (0.84 ± 0.04) on day 1 on day 7 1 . The REE of the
±
They
nutritional
during
quotient
(4).
caused
although
and
associated
of
methods
and fats.
significantly
energy
effects
Fran#{231}oise Mazingue,
treatment,
24%),
71 (85
1588.4 kJ/24 of the control subjects
1 16. 1 kJ/24 able
day
quate
(REE) the
Nelken,
different
subjects
±
carbohydrates
in control comparable
(5057.8
h) was
not
(58
22
improved
significantly lower than (0.79 ± 0.02) but was
patients
in control
day
± 7 1 %) and
involved
carbohydrate
than
and
Brigitte
(weight-for-height
were used for dietary recall in the two groups, expressed as a percentage of normal recommended and sex was
71
by
and tumor necontrol subjects height and body
of the
at diagnosis
standards).
mass
expenditure 22,
treatment. Interleukin (IL)-l/3, IL-6, interferon--y, crosis factor were also measured. Fifteen healthy were matched for age and sex. Body weight and composition
of with
lymphoblastic
reprint
requests
the
range: 2.17-12.25 y, i and age were used as ethical
committee
Informed
written
Gastroenterology,
and Nutrition
University Hospital of Lille, from Guigoz Society, 1995. to F Gottrand,
Service
of the consent
Unit,
France.
de Pediatric,
Hopital
Huriez, 1 Place de Verdun, 59037 Lille, France. Received April 17, 1996. Accepted for publication August 8, 1996. for
Clinical
Nutrition
95
96
DELBECQUE-BOUSSARD
ET
AL
C A
B
Ii
Ii
A
ment.
All
Ii
0930
after
11 Day
I
22
Day
Day 36
Day
Vincristine,
D
Daunombicine,
D
Asparaginase,
20 kg,
100%. The low energy intakes included both
carbohydrates patients had
etry
having
range.
