Optimizing fluid therapy in mechanically ventilated patients after ...

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0.62±1.0) than for central venous pressure (0.451; CI: 0.17±0.74). ... pressure variation; heart, central venous pressure; measurement techniques, pulse contour.
British Journal of Anaesthesia 88 (1): 124±6 (2002)

SHORT COMMUNICATIONS Optimizing ¯uid therapy in mechanically ventilated patients after cardiac surgery by on-line monitoring of left ventricular stroke volume variations. Comparison with aortic systolic pressure variations D. A. Reuter1, T. W. Felbinger1, E. Kilger1, C. Schmidt1, P. Lamm2 and A. E. Goetz1* 1

Department of Anaesthesiology and 2Department of Cardiac Surgery, Ludwig-Maximilians-University, Groûhadern University Hospital, Marchioninistr. 15, D-81377 Munich, Germany *Corresponding author Background. Mechanical ventilation causes changes in left ventricular preload leading to distinct variations in left ventricular stroke volume and systolic arterial pressure. Retrospective off-line quanti®cation of systolic arterial pressure variations (SPV) has been validated as a sensitive method of predicting left ventricular response to volume administration. We report the real-time measurement of left ventricular stroke volume variations (SVV) by continuous arterial pulse contour analysis and compare it with off-line measurements of SPV in patients after cardiac surgery. Methods. SVV and SPV were determined before and after volume loading with colloids in 20 mechanically ventilated patients. Results. SVV and SPV decreased signi®cantly after volume loading and were correlated (r=0.89; P