Oral administration of the amino acids cystine and ... - Semantic Scholar
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ORIGINAL ARTICLE
Oral administration of the amino acids cystine and theanine attenuates the adverse events of S‑1 adjuvant chemotherapy in gastrointestinal cancer patients Takashi Tsuchiya1 · Hiroshi Honda1 · Masaya Oikawa1 · Tetsuya Kakita1 · Atsushi Oyama1 · Hidekazu Oishi1 · Katsuyuki Tochikubo2 · Takanao Hashimoto2 · Shigekazu Kurihara3 · Tetsuro Shibakusa3 · Takashi Kayahara4
Abstract Background Nutritional therapy is used to reduce the adverse events (AEs) of anticancer drugs. Here, we determined whether the amino acids cystine and theanine, which provide substrates for glutathione, attenuated the AEs of S-1 adjuvant chemotherapy. Methods Patients scheduled to receive S-1 adjuvant chemotherapy were randomized to the C/T or the control groups. The C/T group received 700 mg cystine and 280 mg theanine orally 1 week before the administration of S-1, which then continued for 5 weeks. Each group received S-1 for 4 weeks. Blood sampling was performed and AEs were evaluated (CTCAE ver. 4.0) before and after the administration of S-1. S-1 was discontinued when AEs ≥ grade 2 occurred. Results The incidences of AEs of any grade and those over grade 2 were lower in the C/T group than in the controls. The incidence of diarrhea (G ≥ 2) was significantly less (p 100,000/mm3, hemoglobin level >9.0 g/dl, total bilirubin level
