Jul 10, 2011 - neuromuscular respiratory system). (Chest 1991; 99:176-84). The occurrence of the sepsis and multiple organ failure syndrome (critical illness) ...
Peripheral nerve function in sepsis and multiple organ failure. N J Witt, D W Zochodne, C F Bolton, F Grand'Maison, G Wells, G B Young and W J Sibbald Chest 1991;99;176-184 DOI 10.1378/chest.99.1.176 The online version of this article, along with updated information and services can be found online on the World Wide Web at: http://chestjournal.chestpubs.org/content/99/1/176
Chest is the official journal of the American College of Chest Physicians. It has been published monthly since 1935. Copyright1991by the American College of Chest Physicians, 3300 Dundee Road, Northbrook, IL 60062. All rights reserved. No part of this article or PDF may be reproduced or distributed without the prior written permission of the copyright holder. (http://chestjournal.chestpubs.org/site/misc/reprints.xhtml) ISSN:0012-3692
Downloaded from chestjournal.chestpubs.org by guest on July 10, 2011 © 1991 American College of Chest Physicians
Peripheral Nerve Function in Sepsis and Multiple Organ Failure* NorbertJ. Witt, A/.D.,t Douglas WZochodne, M.D.;$ Charles /•". Bolton, M.D.; Francois Grand'Maison, A/.D.;§ George Wells, Ph.D; G. Bryan Young, M.D.; and William J. Sihbald, M.D., F.C.C.P.
Forty-three patients who had sepsis and multiple organ failure (critical illness) were studied prospectively to deter mine the incidence and severity of peripheral nerve func tion and to correlate such function with a number of variables. Electrophysiologic studies indicated a primary uxonal degeneration of motor and sensory fibers in 30 (70 percent). Fifteen (30 percent) had the clinical signs of difficulty in weaning from assisted ventilation, weakness of limb muscles, and reduced or absent deep tendon reflexes. Full recovery from the polyneuropathv occurred among the 23 (53 percent) who survived, except three who had a very severe polyneuropathv. A peripheral nerve function index, computed from electrophysiologic measurements, showed
statistically significant (p1|| .lllllll l.i|.l|l O) s.ll|lll |s .llS(>|l>IS\l|(l(U|.l.l|.> jil'lj pill! ri i.»|M.i\ i|n.s |.iui ni| u IIMJ 'Mji'i [».ii|)ii|\ n.i.x| [iri| oi|.\\ JI.IJHI| un .u. lu >.|ii.i||rd ^Ag i.n|i ni| K 'isaii.i jo jjo^u ^qj jo '.i}j 'it
aq4 04 uoissiuipB jo .nui| aq; uiojj sXsp (061 04 01 g^ jo uBaui E Suunp suopBAjasqo dn-Avo[[oj •¿squiq jnoj j[E ui ^uauiaAOui paonpu; jo XjB^unjoA XUBjo aouasqB—ajaAas SEA\^Eq; Xq^EdojnauXjod E pBq aajqx 'L u! sJSAas Xja}Ejapoui puB §•[ ui p[iui aaaA\ suSis asaqj_ -saxauaj uopua^
'spunoM |«oijijns o) ,)np | i.n| in is .«()(iu p[iioo s)uji)i;d fi] 'W'! ^x,\|EUE tjj^,\\ i|.">ii|.v\ suoij.^npuoD ,i\ MM .ini.jjud jo SE.V\ UOI)d^OX.)
A|UO Jl(J_
'SUDIird
Ef- ,iq)
JOJ
!l| U)Ep ||l! J.1)JI! A|UO JI.MI1ln| 1.1(1 SEM SISA|t!U1!
oiiuupiiAS Jjiqinj UE^JOo|di)|iuu S.1||E|Oj .u.i u jEip
UOITO|3
AIM! SE/V\ . M. H| | Jl
33S
O)
pill!
Downloaded from chestjournal.chestpubs.org by guest on July 10, 2011 © 1991 American College of Chest Physicians
(\e ia HIM) dOW P"6 srades u| uoipunj BAJSNiBJaqduaj
(i/ioujui) 9e
oe
09
081
-yum (uaojad £6'sjifriiu JIMIIJOUs.inMipui —¿) 1111111II | [I' IMIU. >••. St!r>m:i |rniioii luiuds .^qi in ostMJOui in; ipi.w ^sn.jj.iap
^l
91
01
8 - ot-
- 09
m
JO
m
o m x - ooi
Downloaded from chestjournal.chestpubs.org by guest on July 10, 2011 © 1991 American College of Chest Physicians
Table 4—Resultsof Multiple Regression Analysis* Variable Entered
Variables in Model
Serum albumin Days in CCU
Serum albumin Serum albumin, days in CCU Serum albumin, days in CCU, serum glucose
Serum glucose
levels, nutritional factors, water and electrolyte dis turbances, indices of kidney failure, indices of liver failure, and muscle enzymes (creatinine phosphoki-
Analysis of Variance, F Statistic 0.2519 0.3664
11.7826 (p
