Nov 1, 2001 - of 99mTc-tetrofosmin planar scintimammography. The use of SPET is particularly important in the identifica- tion of small non-palpable primary ...
Original article 99mTc-tetrofosmin
SPET in the detection of both primary breast cancer and axillary lymph node metastasis
Angela Spanu1, Giuseppe Dettori2, Susanna Nuvoli1, Alberto Porcu2, Antonio Falchi1, Pierina Cottu2, Maria E. Solinas1, Antonio M. Scanu2, Francesca Chessa1, Giuseppe Madeddu1 1 Department 2 Department
of Nuclear Medicine, University of Sassari, Viale San Pietro, 8, 07100 Sassari, Italy of Surgery, University of Sassari, Sassari, Italy
Abstract. The aim of this study was to evaluate the usefulness of 99mTc-tetrofosmin single-photon emission tomography (SPET) in the detection of both primary breast cancer and axillary lymph node metastasis. We studied 192 consecutive patients in whom primary breast cancer was suspected on the basis of mammography and/or physical examination. After intravenous injection of 740 MBq 99mTc-tetrofosmin, both planar and SPET scintimammography was performed in all patients using a rectangular dual-head gamma camera equipped with low-energy, high-resolution, parallel-hole collimators. In 175 patients with breast cancer at histology, the perlesion overall sensitivity of SPET and planar imaging for the detection of breast cancer was 95.8% and 75.9% (P
