Annals of Oncology 26 (Supplement 7): vii106–vii151, 2015 doi:10.1093/annonc/mdv472.131
Poster session P2
9
1
Risk and epidemiology of cancer related ischemic stroke in head and neck cancer patients
Chung-Yu Chen1, Yaw-Bin Huang1,2, Yu-Ting Wu2 1 Department of Pharmacy, Kaohsiung Medical University Hospital 2 School of Pharmacy, Master Program in Clinical Pharmacy, Kaohsiung Medical University
abstracts
Background: Current evidences showed that increasing risks of ischemic stroke in head and neck cancer have been observed. However, there is limited information to discuss this problem. The aims of the study intended to evaluate risks of ischemic stroke in head and neck cancer patients. Others, we also evaluate the correlation between radiotherapy and chemotherapy.
Methods: We conducted a population based retrospective cohort study by using National Health Insurance Research Database from 1999 to 2009 in Taiwan. This study included patients first time diagnosed with head and neck cancer between 2000 and 2008. Included patients were divided into three groups (1: Surgery alone; group2: RT alone, CT alone, or CCRT (RT/CT/CCRT); group3: Surgery + RT/CT) by their cancer type and treatment methods. Each subject was followed from index date to the end point. We used cox proportional hazard model to evaluate the hazard ratios (HR) of ischemic stroke, by different treatment methods. Results: The HRs of ischemic stroke between cancer and general population about ranged from 3.79 to 4.87 in different cancer type (p < 0.001). Further, patients received RT/CT/ CCRT compared with surgery alone would increase the risk of ischemic stroke (HRs ranged from 1.25 to 1.58), with significantly difference. However, we did not increase the risks of ischemic stroke between between Surgery + RT/CT and surgery alone. Conclusions: Our study found that head and neck cancer patients had higher risk of ischemic stroke than general population. In particularly, patients treated with radiation or chemotherapy compared with surgery alone may enhance hazards for occurrence of ischemic stroke.
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