Sep 5, 2018 - Abstract. Background Acanthosis nigricans (AN) is a skin condition .... Pathophysiology and pharmacological treatment of insulin resistance.
Paediatrica Indonesiana September
VOLUME 50
NUMBER 5
Original Article
Acanthosis nigricans and insulin resistance in obese children Kristellina Sangirta Tirtamulia, Adrian Umboh, Sarah Maria Warouw, Vivekenanda Pateda, Frecillia Regina
Abstract Background Acanthosis nigricans (AN) is a skin condition characterized by darkening and thickening of skin. AN has been UHSRUWHGWREHOLQNHGWRLQVXOLQUHVLVWDQFH ,5 WKDWDVVRFLDWHG ZLWKW\SHGLDEHWHVLQREHVHFKLOGUHQLQPDQ\FRXQWU\ Objective To determine the relation between acanthosis nigricans and insulin resistance in obese children. Methods :H FRQGXFWHG D FURVV VHFWLRQDO VWXG\ LQ :HQDQJ GLVWULFW 0DQDGR IURP 2FWREHU XQWLO -DQXDU\ :H H[DPLQHGREHVHFKLOGUHQDJHG\HDUVIRULQVXOLQUHVLVWDQFH using Homeostasis Model Assessment of Insulin Resistance ,QGH[ +20$,5 :H DQDO\]HG WKH UHVXOWV E\ WWHVW DQG SKL coefficient correlation. The value of P8 &RPSDULVRQ RI +20$,5 EHWZHHQ $1 DQG QRQ$1JURXSZHUHH[SORUHGXVLQJVWXGHQWWWHVW :H DQDO\]HG WKH FRUUHODWLRQ EHWZHHQ $1 DQG ,5 using phi correlation coefficient. Statistical analysis ZDV GRQH XVLQJ 6366 YHUVLRQ 7KH YDOXH RI P
