Volume 4. Issue 8. Pages 1023-1170. 2009 ISSN 1934-578X (printed); ISSN 1555-9475 (online) www.naturalproduct.us
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EDITOR-IN-CHIEF DR. PAWAN K AGRAWAL Natural Product Inc. 7963, Anderson Park Lane, Westerville, Ohio 43081, USA
[email protected] EDITORS PROFESSOR ALESSANDRA BRACA Dipartimento di Chimica Bioorganicae Biofarmacia, Universita di Pisa, via Bonanno 33, 56126 Pisa, Italy
[email protected] PROFESSOR DEAN GUO State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China
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Pancreatic Lipase Inhibitory Alkaloids of Murraya koenigii Leaves
2009 Vol. 4 No. 8 1089 - 1092
Rahul Birari, Somendu Kumar Roy, Anubha Singh and Kamlesh Kumar Bhutani* Department of Natural Products, National Institute of Pharmaceutical Education and Research, (NIPER), S.A.S. Nagar, Punjab - 160 062, India
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[email protected] Received: March 15th, 2009; Accepted: July 27th, 2009
In the continuing search for newer pancreatic lipase inhibitors from plants, a total of 63 extracts from 21 different plants were screened to study their pancreatic lipase (PL) inhibitory activity in vitro. All three extracts (DCM, EtOAc and MeOH) of Murraya koenigii (L.) Spreng leaves (Rutaceae) exhibited antilipase activity greater than 80%. Further, bioactivity guided fractionation of the EtOAc extract led to the isolation of four alkaloids, namely mahanimbin, koenimbin, koenigicine and clausazoline-K, with IC50 values of 17.9 µM, 168.6 µM, 428.6 µM and
