Pathway-based dissection of the genomic ...

Pathway-based dissection of the genomic heterogeneity of cancer hallmarks’ acquisition with SLAPenrich Francesco Iorio, Luz Garcia-Alonso, Jonathan S. Brammeld, Inĩgo Martincorena, David R. Wille, Ultan McDermott, and Julio Saez-Rodriguez

Supplementary Results

Additional File 7: Novel Cancer driver Networks HNSC PRAD Color legend: Sustaining Proliferative Signaling Evading Growth Suppressors Avoiding Immune Destruction % enriched pathways 0

100

Enabling Replicative Immortality Tumour-Promoting Inflammation Activating Invasion and Metastasis Inducing Angiogenesis Genome Instability and Mutation Resisting Cell Death Deregulating Cellular Energetics

BRCA

HDACs Deacetylate Histones FDR = 1.6e−10%, FDR nod = 0.066% Collagen Degradation FDR = 1.1%, FDR nod = 2.2%

ITPR1

CACNA1A

ITPR3

ABCC8

CACNA1D

CACNB2

CACNA2D2

CACNB3

GNAI2

PRKACA

RAPGEF4

SNAP25

SYT5

AHCYL1

ARL2

PRKACG

RAPGEF3

SLC2A1

GNAI1

SLC25A4

STXBP1

unknown CG mut

known HCG mut

wt

CDKN1B HIST1H3B UBC ANAPC5 HIST1H2BC JUN CCNA2 EHMT1 STAT3 ANAPC1 HIST1H2BD HIST2H2BE RPS6KA2 ANAPC4 HIST1H2AJ HIST1H2BH HIST1H3C HIST1H3G HIST1H4L NFKB1 RPS6KA3 CDK2 H2AFZ HIST1H2AC HIST1H2AE HIST1H2BB HIST1H2BE HIST1H2BJ HIST1H2BK MAPK3 RPS6KA1 ANAPC10 ANAPC7 CDK4 CDK6 H2AFX HIST1H2AB HIST1H2BA HIST1H2BF HIST1H2BG HIST1H2BM HIST1H3D HIST1H3F HIST1H3H HIST1H3I HIST1H4C HIST1H4D HIST1H4E HIST1H4J HIST2H2AC RELA UBA52 ANAPC2 CDC27 HIST1H3A HIST1H3J HIST2H3D IL1A IL6 MAPK1 UBE2E1 wt H2AFZ

known HCG mut HIST1H2AJ

unknown CG mut HIST1H2BC

SA054 CSB16 TCGA−AR−A24M−01A−11D−A167−09 TCGA−AO−A03T−01A−21W−A050−09 TCGA−A8−A06Y−01A−21W−A019−09 SA071 CGP_donor_1163909 BR−V−026 CGP_donor_1163918 SA106 TCGA−BH−A0DS−01A−11W−A071−09 CGP_donor_1199104 CGP_donor_1310129 BR−V−064 BRC33 TCGA−BH−A204−01A−11D−A159−09 TCGA−B6−A0WY−01A−11D−A10G−09 TCGA−A8−A08L−01A−11W−A019−09 TCGA−E9−A1RF−01A−11D−A159−09 BR−M−076 CGP_donor_1212368 TCGA−A2−A25B−01A−11D−A167−09 BRC39 BR−M−037 TCGA−A2−A25E−01A−11D−A167−09 CSB8 TCGA−B6−A0IB−01A−11W−A050−09 TCGA−A1−A0SF−01A−11D−A142−09 TCGA−AO−A03P−01A−11W−A019−09 CGP_donor_1163913 TCGA−A8−A09A−01A−11W−A019−09 BR−V−040 TCGA−E9−A1NA−01A−11D−A142−09 BR−M−047 CGP_donor_1163903 BRC41 BR−V−044 TCGA−E2−A1LG−01A−21D−A14K−09 CGP_donor_1234119 BR−M−098 TCGA−D8−A1Y1−01A−21D−A14K−09 TCGA−B6−A0RO−01A−22D−A099−09 TCGA−AR−A24X−01A−11D−A167−09 CSB1 TCGA−AN−A0XW−01A−11D−A10G−09 TCGA−B6−A0IM−01A−11W−A050−09 BR−M−027 TCGA−BH−A0C1−01B−11D−A12B−09 TCGA−A2−A0EO−01A−11W−A050−09 CGP_donor_1212378 BR−V−054 CGP_donor_1234117 TCGA−EW−A1OV−01A−11D−A142−09 TCGA−BH−A0BZ−01A−31D−A12Q−09 TCGA−BH−A0BV−01A−11W−A019−09 TCGA−BH−A1FJ−01A−11D−A13L−09 TCGA−BH−A0W4−01A−11D−A10G−09 TCGA−BH−A0B5−01A−11D−A12Q−09 TCGA−AQ−A1H3−01A−31D−A13L−09 TCGA−A2−A0CS−01A−11D−A10Y−09 CGP_donor_1212369 BRC18 TCGA−A8−A07E−01A−11W−A050−09 BR−M−191 TCGA−EW−A1J6−01A−11D−A188−09 TCGA−E2−A1IJ−01A−11D−A142−09 TCGA−E2−A1IE−01A−11D−A188−09 TCGA−B6−A0RV−01A−11D−A099−09 TCGA−B6−A0RL−01A−11D−A099−09 TCGA−AR−A255−01A−11D−A167−09 TCGA−AO−A1KT−01A−11D−A13L−09 TCGA−AO−A0JM−01A−21W−A071−09 TCGA−A8−A07P−01A−11W−A019−09 TCGA−A8−A06X−01A−21W−A019−09 TCGA−A2−A0YK−01A−22D−A117−09 TCGA−A2−A0T7−01A−21D−A099−09 SA052 CGP_donor_1195182 BR−M−105 CGP_donor_1329919 CGP_donor_1310130 TCGA−EW−A1PB−01A−11D−A142−09 TCGA−E2−A1LH−01A−11D−A14G−09 TCGA−E2−A159−01A−11D−A10Y−09 TCGA−E2−A152−01A−11D−A12B−09 TCGA−D8−A1JJ−01A−31D−A14K−09 TCGA−D8−A1J9−01A−11D−A13L−09 TCGA−C8−A12W−01A−11D−A10Y−09 TCGA−BH−A18U−01A−21D−A12B−09 TCGA−AR−A24S−01A−11D−A167−09 TCGA−AO−A129−01A−21D−A10M−09 TCGA−A8−A09Q−01A−11W−A019−09 TCGA−A8−A092−01A−11W−A019−09 TCGA−A8−A07O−01A−11W−A019−09 TCGA−A8−A07B−01A−11W−A019−09 TCGA−A7−A0DA−01A−31D−A10Y−09 TCGA−A2−A0YM−01A−11D−A10G−09 TCGA−A2−A0YH−01A−11D−A10G−09 TCGA−A2−A0T1−01A−21D−A099−09 TCGA−A2−A0EY−01A−11W−A050−09 CGP_donor_1234118 CGP_donor_1234112 CGP_donor_1230733 CGP_donor_1230727 CGP_donor_1212361 CGP_donor_1199101 CGP_donor_1199074 CGP_donor_1187036 CGP_donor_1163902 BRC4 BRC20 BR−V−060 BR−M−166 TCGA−EW−A1PH−01A−11D−A14K−09 TCGA−EW−A1PA−01A−11D−A142−09 TCGA−EW−A1P4−01A−21D−A142−09 TCGA−EW−A1OZ−01A−11D−A142−09 TCGA−EW−A1OY−01A−11D−A142−09 TCGA−E9−A244−01A−11D−A167−09 TCGA−E9−A243−01A−21D−A167−09 TCGA−E9−A22G−01A−11D−A159−09 TCGA−E9−A226−01A−21D−A159−09 TCGA−E9−A1RB−01A−11D−A17G−09 TCGA−E9−A1NF−01A−11D−A14G−09 TCGA−E9−A1ND−01A−11D−A142−09 TCGA−E9−A1N9−01A−11D−A14G−09 TCGA−E9−A1N8−01A−11D−A142−09 TCGA−E9−A1N5−01A−11D−A14G−09 TCGA−E2−A1LS−01A−12D−A159−09 TCGA−E2−A1LK−01A−21D−A14G−09 TCGA−E2−A1L7−01A−11D−A142−09 TCGA−E2−A1IO−01A−11D−A142−09 TCGA−E2−A1IN−01A−11D−A13L−09 TCGA−E2−A1II−01A−11D−A142−09 TCGA−E2−A1B6−01A−31D−A12Q−09 TCGA−E2−A1B0−01A−11D−A12Q−09 TCGA−E2−A15M−01A−11D−A12B−09 TCGA−E2−A15E−01A−11D−A12B−09 TCGA−E2−A158−01A−11D−A12B−09 TCGA−E2−A155−01A−11D−A12B−09 TCGA−E2−A150−01A−11D−A12B−09 TCGA−E2−A14Z−01A−11D−A10Y−09 TCGA−E2−A14Y−01A−21D−A12B−09 TCGA−E2−A14X−01A−11D−A10Y−09 TCGA−E2−A14R−01A−11D−A10Y−09 TCGA−E2−A14P−01A−31D−A12B−09 TCGA−E2−A14N−01A−31D−A135−09 TCGA−E2−A109−01A−11D−A10M−09 TCGA−E2−A108−01A−13D−A10M−09 TCGA−D8−A27N−01A−11D−A16D−09 TCGA−D8−A27M−01A−11D−A16D−09 TCGA−D8−A27H−01A−11D−A16D−09 TCGA−D8−A1Y3−01A−11D−A159−09 TCGA−D8−A1XZ−01A−11D−A14K−09 TCGA−D8−A1XW−01A−11D−A14K−09 TCGA−D8−A1XT−01A−11D−A14K−09 TCGA−D8−A1XL−01A−11D−A14K−09 TCGA−D8−A1XJ−01A−11D−A14K−09 TCGA−D8−A1XA−01A−11D−A14G−09 TCGA−D8−A1X5−01A−11D−A14G−09 TCGA−D8−A1JL−01A−11D−A13L−09 TCGA−D8−A1JK−01A−11D−A13L−09 TCGA−D8−A1JG−01B−11D−A13L−09 TCGA−D8−A1JF−01A−11D−A13L−09 TCGA−D8−A147−01A−11D−A10Y−09 TCGA−D8−A143−01A−11D−A10Y−09 TCGA−D8−A142−01A−11D−A10Y−09 TCGA−D8−A13Z−01A−11D−A10Y−09 TCGA−D8−A13Y−01A−11D−A10Y−09 TCGA−C8−A27B−01A−11D−A167−09 TCGA−C8−A27A−01A−11D−A167−09 TCGA−C8−A278−01A−11D−A167−09 TCGA−C8−A275−01A−21D−A16D−09 TCGA−C8−A26X−01A−31D−A16D−09 TCGA−C8−A26W−01A−11D−A16D−09 TCGA−C8−A26V−01A−11D−A16D−09 TCGA−C8−A1HK−01A−21D−A13L−09 TCGA−C8−A1HJ−01A−11D−A13L−09 TCGA−C8−A1HG−01A−11D−A135−09 TCGA−C8−A1HF−01A−11D−A135−09 TCGA−C8−A138−01A−11D−A10Y−09 TCGA−C8−A135−01A−11D−A10Y−09 TCGA−C8−A134−01A−11D−A10Y−09 TCGA−C8−A131−01A−11D−A10Y−09 TCGA−C8−A130−01A−31D−A10Y−09 TCGA−C8−A12Z−01A−11D−A10Y−09 TCGA−C8−A12Q−01A−11D−A10Y−09 TCGA−C8−A12P−01A−11D−A10Y−09 TCGA−C8−A12O−01A−11D−A10Y−09 TCGA−C8−A12L−01A−11D−A10Y−09 TCGA−C8−A12K−01A−21D−A10Y−09 TCGA−BH−A208−01A−11D−A159−09 TCGA−BH−A202−01A−11D−A14K−09 TCGA−BH−A1FU−01A−11D−A14G−09 TCGA−BH−A1FN−01A−11D−A13L−09 TCGA−BH−A1FE−01A−11D−A13L−09 TCGA−BH−A1FD−01A−11W−A14Q−09 TCGA−BH−A1FC−01A−11D−A13L−09 TCGA−BH−A1F6−01A−11D−A13L−09 TCGA−BH−A1F0−01A−11D−A135−09 TCGA−BH−A1EY−01A−11D−A13L−09 TCGA−BH−A1EV−01A−11D−A135−09 TCGA−BH−A18V−01A−11D−A12B−09 TCGA−BH−A18T−01A−11D−A12B−09 TCGA−BH−A18Q−01A−12D−A12B−09 TCGA−BH−A18H−01A−11D−A12B−09 TCGA−BH−A0WA−01A−11D−A10G−09 TCGA−BH−A0RX−01A−21D−A099−09 TCGA−BH−A0HY−01A−11W−A071−09 TCGA−BH−A0HX−01A−21W−A071−09 TCGA−BH−A0H7−01A−13W−A071−09 TCGA−BH−A0GY−01A−11W−A071−09 TCGA−BH−A0E6−01A−11W−A050−09 TCGA−BH−A0E0−01A−11W−A071−09 TCGA−BH−A0DL−01A−11D−A10Y−09 TCGA−BH−A0DI−01A−21D−A12Q−09 TCGA−BH−A0C3−01A−21D−A12Q−09 TCGA−BH−A0C0−01A−21W−A071−09 TCGA−BH−A0BT−01A−11D−A12Q−09 TCGA−BH−A0BR−01A−21W−A12T−09 TCGA−BH−A0BP−01A−11D−A10Y−09 TCGA−BH−A0BL−01A−11D−A10Y−09 TCGA−BH−A0BG−01A−11D−A10Y−09 TCGA−BH−A0BF−01A−21D−A12Q−09 TCGA−BH−A0BC−01A−22D−A099−09 TCGA−BH−A0B9−01A−11W−A071−09 TCGA−BH−A0B7−01A−12D−A10Y−09 TCGA−BH−A0B3−01A−11W−A071−09 TCGA−BH−A0B0−01A−21D−A10Y−09 TCGA−BH−A0AW−01A−11W−A071−09 TCGA−BH−A0AV−01A−31D−A10Y−09 TCGA−B6−A1KN−01A−11D−A13L−09 TCGA−B6−A0X1−01A−11D−A10G−09 TCGA−B6−A0WX−01A−11D−A10G−09 TCGA−B6−A0RU−01A−11D−A099−09 TCGA−B6−A0RS−01A−11D−A099−09 TCGA−B6−A0RH−01A−21D−A10Y−09 TCGA−B6−A0RE−01A−11W−A071−09 TCGA−B6−A0IQ−01A−11W−A050−09 TCGA−B6−A0IK−01A−12W−A071−09 TCGA−B6−A0IJ−01A−11W−A050−09 TCGA−B6−A0IE−01A−11W−A050−09 TCGA−B6−A0I9−01A−11W−A050−09 TCGA−B6−A0I2−01A−11W−A050−09 TCGA−AR−A256−01A−11D−A167−09 TCGA−AR−A254−01A−21D−A167−09 TCGA−AR−A24Q−01A−12D−A167−09 TCGA−AR−A24P−01A−11D−A167−09 TCGA−AR−A24K−01A−11D−A167−09 TCGA−AR−A1AY−01A−21D−A12Q−09 TCGA−AR−A1AW−01A−21D−A12Q−09 TCGA−AR−A1AS−01A−11D−A12Q−09 TCGA−AR−A1AQ−01A−11D−A12Q−09 TCGA−AR−A1AP−01A−11D−A12Q−09 TCGA−AR−A1AN−01A−11D−A12Q−09 TCGA−AR−A1AJ−01A−21D−A12Q−09 TCGA−AR−A1AI−01A−11D−A12Q−09 TCGA−AR−A1AH−01A−11D−A12B−09 TCGA−AR−A0U4−01A−11D−A117−09 TCGA−AR−A0U3−01A−11D−A10G−09 TCGA−AR−A0U2−01A−11D−A10G−09 TCGA−AR−A0U1−01A−11D−A10Y−09 TCGA−AR−A0U0−01A−11D−A10G−09 TCGA−AR−A0TV−01A−21D−A099−09 TCGA−AR−A0TS−01A−11D−A10Y−09 TCGA−AR−A0TP−01A−11D−A099−09 TCGA−AQ−A04L−01B−21D−A10M−09 TCGA−AQ−A04J−01A−02W−A050−09 TCGA−AQ−A04H−01B−11D−A10M−09 TCGA−AO−A12G−01A−11D−A10M−09 TCGA−AO−A12D−01A−11D−A10Y−09 TCGA−AO−A124−01A−11D−A10M−09 TCGA−AO−A0JL−01A−11W−A071−09 TCGA−AO−A0JE−01A−11W−A071−09 TCGA−AO−A0JD−01A−11W−A071−09 TCGA−AO−A0JB−01A−11W−A071−09 TCGA−AO−A0J6−01A−11W−A050−09 TCGA−AO−A0J4−01A−11W−A050−09 TCGA−AO−A0J2−01A−11W−A050−09 TCGA−AO−A03V−01A−11D−A10Y−09 TCGA−AO−A03R−01A−21W−A050−09 TCGA−AO−A03O−01A−11W−A019−09 TCGA−AO−A03N−01B−11D−A10M−09 TCGA−AO−A03L−01A−41W−A071−09 TCGA−AN−A0XU−01A−11D−A10G−09 TCGA−AN−A0XT−01A−11D−A10G−09 TCGA−AN−A0XN−01A−21D−A10G−09 TCGA−AN−A0G0−01A−11W−A050−09 TCGA−AN−A0FY−01A−11W−A050−09 TCGA−AN−A0FX−01A−11W−A050−09 TCGA−AN−A0FV−01A−11W−A019−09 TCGA−AN−A0FT−01A−11W−A050−09 TCGA−AN−A0FL−01A−11W−A050−09 TCGA−AN−A0FJ−01A−11W−A019−09 TCGA−AN−A0AR−01A−11W−A019−09 TCGA−AN−A0AL−01A−11W−A019−09 TCGA−AN−A0AJ−01A−11W−A019−09 TCGA−AN−A04C−01A−21W−A050−09 TCGA−A8−A09X−01A−11W−A019−09 TCGA−A8−A09N−01A−11W−A019−09 TCGA−A8−A097−01A−11W−A050−09 TCGA−A8−A08X−01A−21W−A019−09 TCGA−A8−A08R−01A−11W−A050−09 TCGA−A8−A08P−01A−11W−A019−09 TCGA−A8−A08I−01A−11W−A019−09 TCGA−A8−A084−01A−21W−A019−09 TCGA−A8−A081−01A−11W−A019−09 TCGA−A8−A07W−01A−11W−A019−09 TCGA−A8−A07U−01A−11W−A050−09 TCGA−A8−A07R−01A−21W−A050−09 TCGA−A8−A079−01A−21W−A019−09 TCGA−A8−A075−01A−11D−A099−09 TCGA−A8−A06Q−01A−11W−A050−09 TCGA−A8−A06O−01A−11W−A019−09 TCGA−A7−A26I−01A−11D−A167−09 TCGA−A7−A26G−01A−21D−A167−09 TCGA−A7−A26F−01A−21D−A167−09 TCGA−A7−A13D−01A−13D−A12Q−09 TCGA−A7−A0CJ−01A−21W−A019−09 TCGA−A7−A0CE−01A−11W−A019−09 TCGA−A2−A1G1−01A−21D−A13L−09 TCGA−A2−A0YT−01A−11D−A10G−09 TCGA−A2−A0YJ−01A−11D−A10G−09 TCGA−A2−A0YG−01A−21D−A10G−09 TCGA−A2−A0T3−01A−21D−A10Y−09 TCGA−A2−A0T2−01A−11W−A097−09 TCGA−A2−A0SX−01A−12D−A099−09 TCGA−A2−A0SW−01A−11D−A099−09 TCGA−A2−A0SV−01A−11D−A099−09 TCGA−A2−A0EQ−01A−11W−A050−09 TCGA−A2−A0D2−01A−21W−A050−09 TCGA−A2−A0D1−01A−11W−A050−09 TCGA−A2−A0D0−01A−11W−A019−09 TCGA−A2−A0CX−01A−21W−A019−09 TCGA−A2−A0CW−01A−21D−A10Y−09 TCGA−A2−A0CM−01A−31W−A050−09 TCGA−A2−A04W−01A−31D−A10Y−09 TCGA−A2−A04U−01A−11D−A10Y−09 TCGA−A2−A04P−01A−31D−A128−09 TCGA−A1−A0SP−01A−11D−A099−09 TCGA−A1−A0SO−01A−22D−A099−09 TCGA−A1−A0SK−01A−12D−A099−09 TCGA−A1−A0SI−01A−11D−A142−09 SA236 SA234 SA228 SA227 SA226 SA219 SA217 SA214 SA213 SA212 SA102 SA101 SA097 SA094 SA093 SA092 SA089 SA084 SA080 SA077 SA076 SA075 SA074 SA073 SA072 SA069 SA067 SA065 SA063 SA056 SA053 SA051 SA030 SA018 CSB9 CSB33 CSB24 CSB15 CGP_donor_1329921 CGP_donor_1329917 CGP_donor_1234116 CGP_donor_1234111 CGP_donor_1230782 CGP_donor_1230730 CGP_donor_1212376 CGP_donor_1212374 CGP_donor_1212371 CGP_donor_1212364 CGP_donor_1212360 CGP_donor_1199135 CGP_donor_1199131 CGP_donor_1199129 CGP_donor_1199128 CGP_donor_1199106 CGP_donor_1199103 CGP_donor_1199100 CGP_donor_1195183 CGP_donor_1187027 CGP_donor_1184343 CGP_donor_1163917 CGP_donor_1163906 CGP_donor_1163901 CGP_donor_1163900 BRC51 BRC47 BRC44 BRC37 BRC31 BRC29 BRC16 BRC13 BR−V−071 BR−V−067 BR−V−051 BR−V−050 BR−V−045 BR−V−043 BR−V−037 BR−V−036 BR−V−033 BR−V−027 BR−V−024 BR−V−022 BR−V−014 BR−V−012 BR−V−008 BR−V−007 BR−V−002 BR−M−192 BR−M−189 BR−M−123 BR−M−122 BR−M−095 BR−M−094 BR−M−085 BR−M−073 BR−M−045 BR−M−034 BR−M−005 BB28T

TCGA−C8−A131−01A−11D−A10Y−09 SA106 TCGA−A2−A0CS−01A−11D−A10Y−09 BRC23 BR−V−043 TCGA−E2−A1LH−01A−11D−A14G−09 TCGA−D8−A1X8−01A−11D−A14K−09 TCGA−A2−A0CV−01A−31D−A10Y−09 TCGA−D8−A1XS−01A−11D−A14K−09 TCGA−AO−A0JE−01A−11W−A071−09 TCGA−A8−A096−01A−11W−A019−09 TCGA−A8−A08B−01A−11W−A019−09 TCGA−E2−A1IU−01A−11D−A14G−09 TCGA−E2−A15L−01A−11D−A12B−09 TCGA−BH−A1FJ−01A−11D−A13L−09 TCGA−BH−A0DL−01A−11D−A10Y−09 TCGA−E9−A1N5−01A−11D−A14G−09 CGP_donor_1212375 TCGA−B6−A0X1−01A−11D−A10G−09 TCGA−AQ−A04L−01B−21D−A10M−09 TCGA−A2−A0YK−01A−22D−A117−09 TCGA−EW−A1PB−01A−11D−A142−09 TCGA−A8−A07W−01A−11W−A019−09 TCGA−A8−A07E−01A−11W−A050−09 SA237 BR−M−191 TCGA−EW−A1P8−01A−11D−A142−09 TCGA−BH−A1EY−01A−11D−A13L−09 TCGA−B6−A0I9−01A−11W−A050−09 TCGA−AR−A256−01A−11D−A167−09 TCGA−AO−A0JA−01A−11W−A071−09 TCGA−A2−A25D−01A−12D−A16D−09 TCGA−E2−A1LK−01A−21D−A14G−09 TCGA−E2−A1IN−01A−11D−A13L−09 TCGA−BH−A0H6−01A−21W−A071−09 TCGA−AQ−A0Y5−01A−11D−A14K−09 TCGA−A2−A04R−01A−41D−A117−09 CGP_donor_1212364 BRC18 BR−V−067 TCGA−E2−A14W−01A−11D−A12B−09 TCGA−E2−A14T−01A−11D−A10Y−09 TCGA−BH−A1F8−01A−11D−A13L−09 TCGA−B6−A0I5−01A−11W−A100−09 TCGA−AR−A1AQ−01A−11D−A12Q−09 TCGA−AN−A0AJ−01A−11W−A019−09 TCGA−A2−A0CU−01A−12W−A050−09 BR−M−174 TCGA−E2−A1B0−01A−11D−A12Q−09 TCGA−D8−A1JK−01A−11D−A13L−09 TCGA−A8−A08P−01A−11W−A019−09 TCGA−A8−A08L−01A−11W−A019−09 TCGA−A2−A1FX−01A−11D−A13L−09 CGP_donor_1199131 BR−M−184 BR−M−085 BR−M−027 TCGA−A8−A06Q−01A−11W−A050−09 TCGA−A2−A0SY−01A−31D−A099−09 TCGA−EW−A1OZ−01A−11D−A142−09 TCGA−E2−A105−01A−11D−A10M−09 TCGA−D8−A1Y3−01A−11D−A159−09 TCGA−BH−A1FC−01A−11D−A13L−09 TCGA−BH−A0DD−01A−31D−A12Q−09 TCGA−B6−A0RL−01A−11D−A099−09 TCGA−AR−A24H−01A−11D−A167−09 CGP_donor_1234118 CGP_donor_1163918 BR−V−013 TCGA−E2−A1BD−01A−11D−A12Q−09 TCGA−AR−A24Q−01A−12D−A167−09 TCGA−EW−A1P3−01A−11D−A142−09 TCGA−E2−A1IH−01A−11D−A188−09 TCGA−E2−A14S−01A−11D−A12B−09 TCGA−C8−A274−01A−11D−A16D−09 TCGA−BH−A1FM−01A−11D−A13L−09 TCGA−BH−A0BP−01A−11D−A10Y−09 TCGA−A8−A079−01A−21W−A019−09 TCGA−A7−A26H−01A−11D−A167−09 TCGA−A2−A0SU−01A−11D−A099−09 CGP_donor_1212361 TCGA−AR−A0U4−01A−11D−A117−09 TCGA−EW−A1P6−01A−11D−A142−09 TCGA−E2−A1IG−01A−11D−A142−09 TCGA−D8−A1Y2−01A−11D−A159−09 TCGA−D8−A140−01A−11D−A10Y−09 TCGA−BH−A1EO−01A−11D−A135−09 TCGA−BH−A0W4−01A−11D−A10G−09 TCGA−A8−A09W−01A−11W−A019−09 TCGA−A8−A09B−01A−11W−A019−09 SA224 CGP_donor_1199128 CGP_donor_1199106 CGP_donor_1187029 CGP_donor_1230733 TCGA−BH−A0AW−01A−11W−A071−09 TCGA−AN−A0FX−01A−11W−A050−09 TCGA−A8−A08R−01A−11W−A050−09 TCGA−E2−A14V−01A−11D−A12B−09 TCGA−E2−A108−01A−13D−A10M−09 TCGA−D8−A27H−01A−11D−A16D−09 TCGA−C8−A12T−01A−11D−A10Y−09 TCGA−B6−A0RU−01A−11D−A099−09 TCGA−AR−A255−01A−11D−A167−09 TCGA−AO−A12H−01A−11D−A10Y−09 TCGA−AO−A0J5−01A−11W−A050−09 TCGA−AO−A03R−01A−21W−A050−09 TCGA−AN−A0FW−01A−11W−A050−09 TCGA−A8−A09M−01A−11W−A019−09 TCGA−A2−A0EW−01A−21D−A10Y−09 CSB1 CGP_donor_1212369 CGP_donor_1199074 CGP_donor_1163907 BR−V−064 BR−M−193 BR−M−105 BR−M−005

Senescence Associated Secretory Phenotype (SASP) FDR = 0.00031%, FDR nod = 0.016% Packaging Of Telomere Ends FDR = 1.3e−10%, FDR nod = 1.2e−09%

HIST1H2BD

HIST2H2BE

TERF2

HIST1H2BH

HIST1H4L

POT1

ACD

HIST1H2AC

HIST1H2AE

HIST1H2BB

HIST1H2BE

HIST1H2BF

HIST1H2BG

HIST1H2BK

HIST1H4E

TERF2IP

H2AFX

HIST1H2AB

HIST1H2BA

HIST1H2BJ

HIST1H2BM

HIST1H4C

HIST1H4D

HIST1H4J

HIST2H2AC

HIST3H3

wt wt ITPR2

wt wt

known HCG mut known HCG mut CACNA1C

known HCG mut known HCG mut

unknown CG mut TP53 ATM CDKN1B HIST1H2BC HIST2H2BE RAD50 EP400 HIST1H2AJ HIST1H2BD ACD CCNE1 CDK2 H2AFZ HIST1H2BE HIST1H2BG HIST1H2BJ HIST1H4L TERF2IP CCNA2 CCNE2 H2AFX HIST1H2AC HIST1H2BA HIST1H2BB HIST1H2BH HIST1H2BM HIST1H4C HIST1H4D HIST1H4E HIST1H4J HIST2H2AC MRE11A NBN HIST1H2AB HIST1H2AE HIST1H2BF HIST1H2BK HIST3H3 POT1 TERF2 unknown CG mut CACNA1E

TCGA−A2−A0EM−01A−11W−A050−09 SA054 TCGA−E2−A15C−01A−31D−A12B−09 CGP_donor_1163919 TCGA−AN−A0XL−01A−11D−A10M−09 TCGA−AO−A03T−01A−21W−A050−09 BR−M−076 TCGA−A8−A06Y−01A−21W−A019−09 CGP_donor_1163909 BR−V−026 TCGA−AN−A0FW−01A−11W−A050−09 TCGA−D8−A1XW−01A−11D−A14K−09 BR−V−027 TCGA−E9−A247−01A−11D−A167−09 TCGA−C8−A12L−01A−11D−A10Y−09 CGP_donor_1163918 TCGA−A2−A0EY−01A−11W−A050−09 CSB8 TCGA−BH−A0DS−01A−11W−A071−09 CGP_donor_1199104 TCGA−A8−A07F−01A−11W−A019−09 TCGA−A2−A04R−01A−41D−A117−09 TCGA−E9−A1R7−01A−11D−A14K−09 TCGA−BH−A0B0−01A−21D−A10Y−09 TCGA−AN−A0XW−01A−11D−A10G−09 TCGA−A8−A08I−01A−11W−A019−09 TCGA−E2−A155−01A−11D−A12B−09 BR−V−019 TCGA−BH−A0W7−01A−11D−A10Y−09 TCGA−B6−A0RE−01A−11W−A071−09 TCGA−D8−A1XV−01A−11D−A14K−09 CSB7 TCGA−AO−A1KS−01A−11D−A13L−09 BRC7 TCGA−BH−A0DT−01A−21D−A12B−09 TCGA−BH−A0AV−01A−31D−A10Y−09 SA071 CGP_donor_1199074 TCGA−EW−A1PB−01A−11D−A142−09 TCGA−A2−A0T1−01A−21D−A099−09 TCGA−A2−A25B−01A−11D−A167−09 CGP_donor_1212368 BRC39 BR−M−037 TCGA−AR−A24S−01A−11D−A167−09 TCGA−A8−A09Q−01A−11W−A019−09 CGP_donor_1310129 BR−M−166 TCGA−A2−A25A−01A−12D−A16D−09 CSB12 TCGA−C8−A138−01A−11D−A10Y−09 TCGA−A8−A09W−01A−11W−A019−09 CGP_donor_1212378 TCGA−BH−A0C1−01B−11D−A12B−09 BR−V−054 TCGA−AN−A03Y−01A−21W−A019−09 TCGA−A7−A26J−01A−11D−A167−09 CGP_donor_1212376 CGP_donor_1230733 TCGA−C8−A130−01A−31D−A10Y−09 TCGA−A8−A097−01A−11W−A050−09 SA106 CGP_donor_1234112 CGP_donor_1230727 BR−V−044 CGP_donor_1163903 BRC41 TCGA−E2−A1LI−01A−12D−A159−09 TCGA−E2−A1IU−01A−11D−A14G−09 TCGA−C8−A12Z−01A−11D−A10Y−09 TCGA−E2−A1LG−01A−21D−A14K−09 CGP_donor_1234119 BR−M−098 TCGA−E9−A1R3−01A−31D−A14K−09 TCGA−A2−A0YK−01A−22D−A117−09 TCGA−A2−A0YF−01A−21D−A10G−09 TCGA−A7−A0DA−01A−31D−A10Y−09 TCGA−BH−A0BR−01A−21W−A12T−09 TCGA−AR−A0TU−01A−31D−A10G−09 TCGA−C8−A12P−01A−11D−A10Y−09 TCGA−AN−A0FD−01A−11W−A050−09 TCGA−A8−A06O−01A−11W−A019−09 TCGA−A2−A0CT−01A−31W−A071−09 TCGA−A2−A25E−01A−11D−A167−09 TCGA−A8−A07L−01A−11W−A019−09 TCGA−A7−A0CH−01A−21W−A019−09 CSB23 CGP_donor_1234117 TCGA−EW−A1OV−01A−11D−A142−09 TCGA−E2−A152−01A−11D−A12B−09 TCGA−BH−A0BZ−01A−31D−A12Q−09 TCGA−BH−A0BV−01A−11W−A019−09 TCGA−D8−A1JS−01A−11D−A13L−09 TCGA−B6−A0RP−01A−21D−A099−09 TCGA−AN−A0FJ−01A−11W−A019−09 SA218 CGP_donor_1187021 TCGA−A2−A0EO−01A−11W−A050−09 TCGA−B6−A0IM−01A−11W−A050−09 TCGA−AR−A1AU−01A−11D−A12Q−09 TCGA−AO−A0JA−01A−11W−A071−09 TCGA−A2−A0SY−01A−31D−A099−09 TCGA−A2−A0YM−01A−11D−A10G−09 TCGA−E2−A1IN−01A−11D−A13L−09 TCGA−BH−A0BP−01A−11D−A10Y−09 TCGA−AR−A1AI−01A−11D−A12Q−09 TCGA−A8−A0AB−01A−11W−A050−09 BR−V−067 TCGA−BH−A1FL−01A−11D−A13L−09 TCGA−E2−A15G−01A−11D−A12B−09 TCGA−BH−A18R−01A−11D−A12B−09 TCGA−B6−A0RN−01A−12D−A099−09 TCGA−A8−A096−01A−11W−A019−09 TCGA−A8−A08Z−01A−21W−A019−09 TCGA−A2−A0CS−01A−11D−A10Y−09 TCGA−C8−A26X−01A−31D−A16D−09 TCGA−B6−A0IO−01A−11W−A050−09 TCGA−A8−A091−01A−11W−A019−09 TCGA−A1−A0SO−01A−22D−A099−09 SA214 SA069 CGP_donor_1212359 TCGA−BH−A0HK−01A−11W−A071−09 TCGA−E9−A226−01A−21D−A159−09 TCGA−E2−A1IE−01A−11D−A188−09 TCGA−BH−A1F8−01A−11D−A13L−09 TCGA−A2−A0SX−01A−12D−A099−09 CGP_donor_1212366 BR−V−034 BR−V−016 BR−M−041 TCGA−E2−A159−01A−11D−A10Y−09 TCGA−EW−A1OX−01A−11D−A142−09 TCGA−B6−A0IK−01A−12W−A071−09 TCGA−AR−A24L−01A−11D−A167−09 TCGA−A8−A095−01A−11W−A019−09 TCGA−A7−A13D−01A−13D−A12Q−09 SA097 CGP_donor_1212363 BR−V−013 CSB1 TCGA−A8−A07R−01A−21W−A050−09 TCGA−A2−A04W−01A−31D−A10Y−09 TCGA−E9−A1NG−01A−21D−A14K−09 TCGA−D8−A1JN−01A−11D−A13L−09 TCGA−C8−A27B−01A−11D−A167−09 TCGA−BH−A0E1−01A−11W−A071−09 TCGA−BH−A0DD−01A−31D−A12Q−09 TCGA−B6−A0RS−01A−11D−A099−09 TCGA−B6−A0IJ−01A−11W−A050−09 TCGA−AQ−A1H3−01A−31D−A13L−09 TCGA−AO−A12E−01A−11D−A10M−09 SA077 BRC32 BR−M−095 TCGA−AR−A0TV−01A−21D−A099−09 TCGA−A8−A09I−01A−22W−A050−09 CGP_donor_1212361 TCGA−E9−A22G−01A−11D−A159−09 TCGA−E9−A1RF−01A−11D−A159−09 TCGA−BH−A1FC−01A−11D−A13L−09 TCGA−B6−A0WY−01A−11D−A10G−09 TCGA−B6−A0I6−01A−11D−A128−09 TCGA−AC−A23C−01A−12D−A167−09 TCGA−EW−A1J1−01A−11D−A188−09 TCGA−E9−A1NF−01A−11D−A14G−09 TCGA−E2−A1L7−01A−11D−A142−09 TCGA−E2−A15J−01A−11D−A12Q−09 TCGA−E2−A156−01A−11D−A12B−09 TCGA−E2−A105−01A−11D−A10M−09 TCGA−D8−A1JK−01A−11D−A13L−09 TCGA−D8−A1JJ−01A−31D−A14K−09 TCGA−BH−A0H3−01A−11D−A12Q−09 TCGA−B6−A0IP−01A−11D−A045−09 TCGA−B6−A0I8−01A−11W−A050−09 TCGA−AR−A251−01A−12D−A167−09 TCGA−AR−A24K−01A−11D−A167−09 TCGA−AR−A0TW−01A−11D−A099−09 TCGA−AR−A0TT−01A−31D−A099−09 TCGA−AC−A23E−01A−11D−A159−09 TCGA−A8−A0A2−01A−11W−A050−09 TCGA−A8−A093−01A−11W−A019−09 TCGA−A8−A08R−01A−11W−A050−09 TCGA−A2−A0YC−01A−11D−A117−09 TCGA−A2−A0EV−01A−11W−A050−09 TCGA−A1−A0SN−01A−11D−A142−09 SA073 CGP_donor_1329920 CGP_donor_1329919 CGP_donor_1234111 CGP_donor_1212367 CGP_donor_1199100 BRC24 BR−V−048 BR−M−106

TCGA−A8−A082−01A−11W−A019−09 TCGA−A8−A09N−01A−11W−A019−09 BRC50 TCGA−C8−A1HF−01A−11D−A135−09 BRC47 TCGA−A2−A0T6−01A−11D−A099−09 TCGA−A8−A06Q−01A−11W−A050−09 BR−V−044 TCGA−E9−A244−01A−11D−A167−09 TCGA−A2−A0EQ−01A−11W−A050−09 CGP_donor_1184343 TCGA−EW−A1PH−01A−11D−A14K−09 TCGA−AN−A0FL−01A−11W−A050−09 CGP_donor_1199131 BR−M−122 TCGA−BH−A0HQ−01A−11W−A050−09 CGP_donor_1212366 TCGA−BH−A0C0−01A−21W−A071−09 SA213 BR−M−026 SA229 CGP_donor_1212361 BR−M−174 TCGA−E2−A1B0−01A−11D−A12Q−09 TCGA−E2−A10A−01A−21D−A10Y−09 BR−V−002 TCGA−D8−A1JC−01A−11D−A13L−09 TCGA−AR−A1AP−01A−11D−A12Q−09 CGP_donor_1212375 TCGA−AR−A24Q−01A−12D−A167−09 SA218 CSB30 TCGA−EW−A1IW−01A−11D−A13L−09 TCGA−BH−A1F5−01A−12D−A13L−09 TCGA−B6−A0IE−01A−11W−A050−09 CSB10 TCGA−D8−A13Z−01A−11D−A10Y−09 TCGA−BH−A18Q−01A−12D−A12B−09 TCGA−A7−A26G−01A−21D−A167−09 CGP_donor_1234117 TCGA−E2−A159−01A−11D−A10Y−09 TCGA−BH−A0AW−01A−11W−A071−09 TCGA−B6−A0I8−01A−11W−A050−09 TCGA−A8−A06X−01A−21W−A019−09 TCGA−C8−A274−01A−11D−A16D−09 TCGA−BH−A0HK−01A−11W−A071−09 TCGA−BH−A0C1−01B−11D−A12B−09 TCGA−AR−A0U0−01A−11D−A10G−09 TCGA−AO−A12E−01A−11D−A10M−09 TCGA−AN−A0FJ−01A−11W−A019−09 BR−V−047 BR−V−043 TCGA−BH−A203−01A−12D−A167−09 TCGA−AN−A0FY−01A−11W−A050−09 TCGA−A7−A26H−01A−11D−A167−09 TCGA−A2−A0D2−01A−21W−A050−09 BRC5 TCGA−A8−A097−01A−11W−A050−09 TCGA−EW−A1OZ−01A−11D−A142−09 TCGA−D8−A13Y−01A−11D−A10Y−09 TCGA−BH−A0HN−01A−11D−A099−09 CGP_donor_1212373 TCGA−E2−A14R−01A−11D−A10Y−09 TCGA−BH−A1EY−01A−11D−A13L−09 TCGA−B6−A0RL−01A−11D−A099−09 TCGA−B6−A0RH−01A−21D−A10Y−09 TCGA−A2−A04R−01A−41D−A117−09 BRC38 TCGA−AN−A0XN−01A−21D−A10G−09 TCGA−A8−A07C−01A−11D−A045−09 TCGA−D8−A1XS−01A−11D−A14K−09 TCGA−BH−A204−01A−11D−A159−09 TCGA−BH−A0B4−01A−11W−A019−09 CGP_donor_1199105 CGP_donor_1187029 TCGA−E2−A105−01A−11D−A10M−09 TCGA−BH−A0HU−01A−11W−A050−09 TCGA−AR−A251−01A−12D−A167−09 TCGA−AQ−A04H−01B−11D−A10M−09 TCGA−AN−A0AL−01A−11W−A019−09 TCGA−A2−A0D0−01A−11W−A019−09 CSB19 CGP_donor_1163903 BR−M−106 BB32T TCGA−AN−A0FS−01A−11W−A050−09 TCGA−BH−A0EA−01A−11D−A10Y−09 TCGA−B6−A0WT−01A−11D−A10G−09 TCGA−AN−A0XW−01A−11D−A10G−09 TCGA−A8−A094−01A−11W−A019−09 TCGA−A7−A26F−01A−21D−A167−09 TCGA−A1−A0SH−01A−11D−A099−09 TCGA−A1−A0SD−01A−11D−A10Y−09 CGP_donor_1212360 CGP_donor_1163917 BR−M−126 TCGA−C8−A12Q−01A−11D−A10Y−09 SA106 SA071 CGP_donor_1329919 TCGA−EW−A1OY−01A−11D−A142−09 TCGA−E2−A152−01A−11D−A12B−09 TCGA−BH−A1FC−01A−11D−A13L−09 TCGA−BH−A0DL−01A−11D−A10Y−09 TCGA−AR−A1AI−01A−11D−A12Q−09 TCGA−AN−A0XO−01A−11D−A10G−09 TCGA−A8−A095−01A−11W−A019−09 TCGA−A8−A07R−01A−21W−A050−09 TCGA−A2−A0T0−01A−22D−A099−09 BRC39 BRC13 BR−V−064 BR−M−095

DNA Damage/Telomere Stress Induced Senescence FDR = 7e−12%, FDR nod = 0.0024% Regulation Of Insulin Secretion FDR = 0.57%, FDR nod = 1.2%

unknown CG mut NCOR1 CHD4 ARID4B HIST1H3B NCOR2 TBL1XR1 CHD3 GPS2 HDAC1 HIST1H2BC HIST1H2AI TBL1X HDAC2 HDAC8 HIST1H2AJ HIST1H2AK HIST1H2BD HIST1H2BH HIST1H3C HIST1H3G HIST2H2BE BRMS1 GATAD2A HIST1H2AC HIST1H2AE HIST1H2BG HIST1H2BJ HIST1H2BK HIST1H4E MTA3 RBBP7 REST ARID4A GATAD2B HDAC10 HDAC3 HIST1H2AA HIST1H2AB HIST1H2AG HIST1H2AH HIST1H2AL HIST1H2AM HIST1H2BA HIST1H2BB HIST1H2BE HIST1H2BF HIST1H2BM HIST1H3D HIST1H3F HIST1H3H HIST1H3I HIST1H3J HIST1H4C HIST1H4D HIST1H4J HIST1H4L HIST2H2AC HIST2H2BF KDM1A MBD3 RBBP4 HIST1H3A HIST2H3D MTA1 MTA2 RCOR1 SUDS3 unknown CG mut COL12A1 COL14A1 COL19A1 COL15A1 COL18A1 COL16A1 COL9A1 COL13A1 COL17A1 COL23A1 COL25A1 COL9A3 ADAM9 MMP14 MMP15 MMP2 MMP8 CTSB MMP1 MMP11 ADAM17 COL26A1 COL9A2 CTSD ELANE FURIN MMP10 MMP19 MMP20 MMP3 ADAM10 MMP9 PHYKPL

TCGA−A2−A0T0−01A−22D−A099−09 TCGA−E9−A1R4−01A−21D−A14G−09 TCGA−BH−A0E6−01A−11W−A050−09 TCGA−AO−A03T−01A−21W−A050−09 TCGA−A8−A06Y−01A−21W−A019−09 CGP_donor_1199074 CGP_donor_1163909 BR−V−026 TCGA−D8−A1XW−01A−11D−A14K−09 BR−V−027 TCGA−E9−A247−01A−11D−A167−09 TCGA−C8−A12L−01A−11D−A10Y−09 CGP_donor_1163918 BR−M−037 TCGA−A2−A0EY−01A−11W−A050−09 CGP_donor_1199104 TCGA−AN−A0XW−01A−11D−A10G−09 BR−V−064 TCGA−AN−A0FW−01A−11W−A050−09 TCGA−A8−A08S−01A−11W−A050−09 TCGA−AO−A1KS−01A−11D−A13L−09 TCGA−C8−A274−01A−11D−A16D−09 TCGA−EW−A1IY−01A−11D−A188−09 TCGA−BH−A0AY−01A−21W−A019−09 TCGA−BH−A0E1−01A−11W−A071−09 CSB25 TCGA−EW−A1PB−01A−11D−A142−09 TCGA−A2−A0T1−01A−21D−A099−09 TCGA−A2−A25B−01A−11D−A167−09 CGP_donor_1212368 TCGA−A2−A25E−01A−11D−A167−09 CSB8 TCGA−A7−A0DA−01A−31D−A10Y−09 TCGA−BH−A0DS−01A−11W−A071−09 TCGA−AR−A24S−01A−11D−A167−09 TCGA−A8−A09Q−01A−11W−A019−09 CGP_donor_1310129 BR−M−166 TCGA−B6−A0IB−01A−11W−A050−09 TCGA−A1−A0SF−01A−11D−A142−09 TCGA−AO−A03P−01A−11W−A019−09 CGP_donor_1163913 TCGA−D8−A1XJ−01A−11D−A14K−09 TCGA−BH−A0BW−01A−11D−A10Y−09 TCGA−BH−A0BL−01A−11D−A10Y−09 TCGA−E2−A1LH−01A−11D−A14G−09 TCGA−AR−A256−01A−11D−A167−09 TCGA−AR−A24L−01A−11D−A167−09 TCGA−E9−A1RF−01A−11D−A159−09 TCGA−A2−A0YM−01A−11D−A10G−09 BR−M−076 TCGA−B6−A0WY−01A−11D−A10G−09 TCGA−A7−A26J−01A−11D−A167−09 CGP_donor_1212376 CGP_donor_1230733 TCGA−C8−A130−01A−31D−A10Y−09 TCGA−A8−A097−01A−11W−A050−09 CGP_donor_1234112 SA106 CGP_donor_1230727 TCGA−E2−A1LG−01A−21D−A14K−09 CGP_donor_1234119 BR−M−098 TCGA−E9−A1NI−01A−11W−A16H−09 TCGA−A8−A07R−01A−21W−A050−09 BR−M−079 TCGA−C8−A1HJ−01A−11D−A13L−09 TCGA−BH−A0C3−01A−21D−A12Q−09 TCGA−AR−A24H−01A−11D−A167−09 TCGA−A7−A13D−01A−13D−A12Q−09 TCGA−BH−A0C1−01B−11D−A12B−09 TCGA−A2−A0EO−01A−11W−A050−09 CGP_donor_1212378 BR−V−054 CGP_donor_1212361 CGP_donor_1163903 BRC41 BR−V−044 TCGA−A8−A06X−01A−21W−A019−09 CGP_donor_1199100 BR−V−070 BR−M−030 BR−V−014 TCGA−E9−A1R7−01A−11D−A14K−09 TCGA−D8−A1JK−01A−11D−A13L−09 TCGA−BH−A0B0−01A−21D−A10Y−09 SA216 TCGA−E2−A14P−01A−31D−A12B−09 TCGA−D8−A27T−01A−11D−A16D−09 TCGA−A8−A09M−01A−11W−A019−09 TCGA−A2−A04U−01A−11D−A10Y−09 BB13T CGP_donor_1329919 TCGA−A2−A0YH−01A−11D−A10G−09 TCGA−BH−A204−01A−11D−A159−09 TCGA−A8−A07B−01A−11W−A019−09 CGP_donor_1187036 CSB1 BRC39 TCGA−D8−A1JJ−01A−31D−A14K−09 TCGA−B6−A0RN−01A−12D−A099−09 TCGA−A7−A26H−01A−11D−A167−09 SA210 TCGA−E2−A159−01A−11D−A10Y−09 CGP_donor_1234117 TCGA−EW−A1OV−01A−11D−A142−09 TCGA−E2−A152−01A−11D−A12B−09 TCGA−BH−A0BZ−01A−31D−A12Q−09 TCGA−BH−A0BV−01A−11W−A019−09 TCGA−AR−A0U4−01A−11D−A117−09 SA071 TCGA−BH−A0DL−01A−11D−A10Y−09 TCGA−B6−A0IO−01A−11W−A050−09 TCGA−AR−A1AI−01A−11D−A12Q−09 TCGA−AO−A03N−01B−11D−A10M−09 TCGA−AN−A03Y−01A−21W−A019−09 TCGA−E2−A10B−01A−11D−A10M−09 TCGA−D8−A143−01A−11D−A10Y−09 TCGA−BH−A0BD−01A−11W−A050−09 TCGA−B6−A0WZ−01A−11D−A10G−09 TCGA−AR−A24N−01A−11D−A167−09 TCGA−A2−A0SU−01A−11D−A099−09 TCGA−A2−A0D1−01A−11W−A050−09 BR−M−005 CGP_donor_1212366 TCGA−E9−A226−01A−21D−A159−09 TCGA−E2−A1IE−01A−11D−A188−09 TCGA−BH−A1F8−01A−11D−A13L−09 TCGA−BH−A0HK−01A−11W−A071−09 TCGA−A8−A09I−01A−22W−A050−09 TCGA−A2−A0SX−01A−12D−A099−09 BR−V−034 BR−V−016 BR−M−041 TCGA−BH−A0B5−01A−11D−A12Q−09 TCGA−BH−A1FJ−01A−11D−A13L−09 TCGA−BH−A0W4−01A−11D−A10G−09 TCGA−AQ−A1H3−01A−31D−A13L−09 TCGA−A8−A092−01A−11W−A019−09 TCGA−A8−A07E−01A−11W−A050−09 TCGA−A2−A0CS−01A−11D−A10Y−09 CGP_donor_1212369 BRC20 BRC18

TCGA−C8−A12W−01A−11D−A10Y−09 TCGA−AO−A03T−01A−21W−A050−09 TCGA−A8−A06Y−01A−21W−A019−09 CGP_donor_1163909 BR−V−026 CGP_donor_1163918 TCGA−A2−A25B−01A−11D−A167−09 CGP_donor_1199104 TCGA−AN−A0XW−01A−11D−A10G−09 BR−V−064 TCGA−B6−A0WY−01A−11D−A10G−09 TCGA−A8−A08L−01A−11W−A019−09 SA071 CGP_donor_1199074 TCGA−EW−A1PB−01A−11D−A142−09 TCGA−A2−A0T1−01A−21D−A099−09 BRC39 BR−M−037 TCGA−A2−A0EY−01A−11W−A050−09 CSB1 TCGA−A2−A25E−01A−11D−A167−09 CSB8 TCGA−BH−A0DS−01A−11W−A071−09 TCGA−A7−A0DA−01A−31D−A10Y−09 TCGA−AR−A24S−01A−11D−A167−09 TCGA−A8−A09Q−01A−11W−A019−09 CGP_donor_1310129 BR−M−166 TCGA−B6−A0IB−01A−11W−A050−09 TCGA−A1−A0SF−01A−11D−A142−09 TCGA−E9−A1NA−01A−11D−A142−09 BR−M−047 CGP_donor_1212368 SA054 CGP_donor_1310130 TCGA−E9−A1RF−01A−11D−A159−09 TCGA−A2−A0YM−01A−11D−A10G−09 BR−M−076 SA106 CGP_donor_1234112 CGP_donor_1230727 TCGA−E2−A1LG−01A−21D−A14K−09 CGP_donor_1234119 BR−M−098 TCGA−E2−A1LH−01A−11D−A14G−09 CGP_donor_1234118 CGP_donor_1163902 BR−M−191 TCGA−BH−A0C1−01B−11D−A12B−09 TCGA−A2−A0EO−01A−11W−A050−09 CGP_donor_1212378 BR−V−054 CGP_donor_1212361 CGP_donor_1163903 BRC41 BR−V−044 CGP_donor_1234117 TCGA−EW−A1OV−01A−11D−A142−09 TCGA−E2−A159−01A−11D−A10Y−09 TCGA−E2−A152−01A−11D−A12B−09 TCGA−BH−A0BZ−01A−31D−A12Q−09 TCGA−BH−A0BV−01A−11W−A019−09

DNA Damage/Telomere Stress Induced Senescence FDR = 7e−12%, FDR nod = 0.0024%

BRC24 TCGA−EW−A1PA−01A−11D−A142−09 CSB16 BR−M−045 TCGA−C8−A1HN−01A−11D−A135−09 TCGA−C8−A12W−01A−11D−A10Y−09 TCGA−AO−A03T−01A−21W−A050−09 TCGA−A8−A06Y−01A−21W−A019−09 CGP_donor_1163909 BR−V−026 TCGA−AN−A0FW−01A−11W−A050−09 TCGA−E9−A247−01A−11D−A167−09 TCGA−C8−A12L−01A−11D−A10Y−09 CGP_donor_1163918 TCGA−A2−A0T1−01A−21D−A099−09 BR−M−037 TCGA−A2−A0EY−01A−11W−A050−09 CGP_donor_1199104 BR−V−064 TCGA−BH−A0AV−01A−31D−A10Y−09 TCGA−A8−A08S−01A−11W−A050−09 TCGA−EW−A1P4−01A−21D−A142−09 BR−V−012 TCGA−D8−A27W−01A−11D−A16D−09 TCGA−AR−A256−01A−11D−A167−09 TCGA−BH−A18U−01A−21D−A12B−09 TCGA−AR−A24M−01A−11D−A167−09 TCGA−D8−A1X9−01A−12D−A159−09 TCGA−C8−A1HE−01A−11D−A188−09 SA071 CGP_donor_1199074 TCGA−A7−A0DA−01A−31D−A10Y−09 TCGA−D8−A1XW−01A−11D−A14K−09 TCGA−C8−A130−01A−31D−A10Y−09 TCGA−A8−A097−01A−11W−A050−09 TCGA−A2−A25B−01A−11D−A167−09 CGP_donor_1212368 TCGA−A2−A25E−01A−11D−A167−09 CSB8 TCGA−A8−A09Q−01A−11W−A019−09 TCGA−AR−A24S−01A−11D−A167−09 CGP_donor_1310129 BR−M−166 TCGA−B6−A0IB−01A−11W−A050−09 TCGA−A1−A0SF−01A−11D−A142−09 TCGA−AO−A03P−01A−11W−A019−09 CGP_donor_1163913 TCGA−EW−A1PB−01A−11D−A142−09 TCGA−D8−A146−01A−31D−A10Y−09 TCGA−A2−A25A−01A−12D−A16D−09 TCGA−D8−A1Y0−01A−11D−A14K−09 TCGA−BH−A209−01A−11D−A17G−09 SA219 BR−V−027 TCGA−BH−A1FN−01A−11D−A13L−09 TCGA−BH−A0HW−01A−11W−A050−09 TCGA−E2−A1IN−01A−11D−A13L−09 TCGA−E2−A14Z−01A−11D−A10Y−09 CGP_donor_1163916 TCGA−E9−A1RF−01A−11D−A159−09 TCGA−A2−A0YM−01A−11D−A10G−09 BR−M−076 CGP_donor_1234112 SA106 CGP_donor_1230727 TCGA−E2−A1LG−01A−21D−A14K−09 CGP_donor_1234119 BR−M−098 TCGA−E9−A22G−01A−11D−A159−09 TCGA−BH−A0W7−01A−11D−A10Y−09 TCGA−A8−A084−01A−21W−A019−09 CGP_donor_1212360 CSB1 TCGA−AN−A0XW−01A−11D−A10G−09 TCGA−B6−A0IM−01A−11W−A050−09 BRC4 TCGA−BH−A0C1−01B−11D−A12B−09 TCGA−A2−A0EO−01A−11W−A050−09 CGP_donor_1212378 BR−V−054 TCGA−B6−A0WY−01A−11D−A10G−09 TCGA−AN−A03Y−01A−21W−A019−09 TCGA−A7−A26J−01A−11D−A167−09 CGP_donor_1212376 BR−V−044 CGP_donor_1212361 CGP_donor_1163903 BRC41 TCGA−E2−A159−01A−11D−A10Y−09 TCGA−EW−A1OV−01A−11D−A142−09 TCGA−E2−A152−01A−11D−A12B−09 TCGA−BH−A0BV−01A−11W−A019−09 TCGA−D8−A27F−01A−11D−A16D−09 TCGA−AO−A0JE−01A−11W−A071−09 TCGA−A8−A0A7−01A−11W−A019−09 TCGA−A8−A06O−01A−11W−A019−09 TCGA−B6−A0I9−01A−11W−A050−09 SA069 CGP_donor_1199135 CGP_donor_1199101 BRC50 TCGA−A8−A09I−01A−22W−A050−09 TCGA−E9−A226−01A−21D−A159−09 TCGA−BH−A1F8−01A−11D−A13L−09 TCGA−BH−A0HK−01A−11W−A071−09 TCGA−A2−A0SX−01A−12D−A099−09 CGP_donor_1212366 BR−V−034 BR−V−016 BR−M−041 TCGA−BH−A0DS−01A−11W−A071−09 BRC39 BR−M−027 TCGA−E2−A1L9−01A−11D−A13L−09 TCGA−BH−A0WA−01A−11D−A10G−09 TCGA−B6−A0X1−01A−11D−A10G−09 TCGA−AR−A0U4−01A−11D−A117−09 TCGA−AN−A0XU−01A−11D−A10G−09 TCGA−A7−A26H−01A−11D−A167−09 TCGA−A1−A0SO−01A−22D−A099−09 TCGA−A1−A0SH−01A−11D−A099−09 CGP_donor_1230730 BR−V−036 CGP_donor_1234117 TCGA−D8−A1JG−01B−11D−A13L−09 TCGA−BH−A0BZ−01A−31D−A12Q−09 TCGA−A1−A0SI−01A−11D−A142−09 TCGA−E9−A1NC−01A−12W−A16L−09 TCGA−E2−A15E−01A−11D−A12B−09 TCGA−C8−A26Z−01A−11D−A16D−09 TCGA−C8−A12Y−01A−11D−A12B−09 TCGA−BH−A1EV−01A−11D−A135−09 TCGA−B6−A0I8−01A−11W−A050−09 TCGA−B6−A0I6−01A−11D−A128−09 TCGA−AO−A125−01A−11D−A10M−09 TCGA−AN−A04C−01A−21W−A050−09 TCGA−A8−A09R−01A−11W−A019−09 TCGA−A2−A04P−01A−31D−A128−09 CGP_donor_1234110 BR−M−120 TCGA−C8−A12T−01A−11D−A10Y−09 BR−V−023 TCGA−EW−A1PE−01A−11D−A142−09 TCGA−E2−A14W−01A−11D−A12B−09 TCGA−AR−A1AI−01A−11D−A12Q−09 TCGA−AO−A124−01A−11D−A10M−09 TCGA−AN−A0AT−01A−11D−A045−09 TCGA−A8−A08L−01A−11W−A019−09 TCGA−A8−A085−01A−11W−A019−09 TCGA−A8−A07I−01A−11W−A019−09 TCGA−A2−A25F−01A−11D−A167−09 TCGA−A2−A0T0−01A−22D−A099−09 TCGA−A2−A0SU−01A−11D−A099−09 SA072 SA065 CSB2 CGP_donor_1212373 CGP_donor_1187027 BR−V−037 CGP_donor_1230733 TCGA−E2−A1IE−01A−11D−A188−09 CGP_donor_1329919 TCGA−EW−A1J6−01A−11D−A188−09 TCGA−E2−A1IJ−01A−11D−A142−09 TCGA−D8−A1J9−01A−11D−A13L−09 TCGA−B6−A0RV−01A−11D−A099−09 TCGA−B6−A0RL−01A−11D−A099−09 TCGA−AR−A255−01A−11D−A167−09 TCGA−AO−A1KT−01A−11D−A13L−09 TCGA−AO−A129−01A−21D−A10M−09 TCGA−AO−A0JM−01A−21W−A071−09 TCGA−A8−A07P−01A−11W−A019−09 TCGA−A8−A07O−01A−11W−A019−09 TCGA−A8−A07E−01A−11W−A050−09 TCGA−A8−A06X−01A−21W−A019−09 TCGA−A2−A0YK−01A−22D−A117−09 TCGA−A2−A0T7−01A−21D−A099−09 SA052 CGP_donor_1195182 BR−V−060 BR−M−191 BR−M−105

BR−M−074 TCGA−E9−A1R4−01A−21D−A14G−09 TCGA−D8−A27W−01A−11D−A16D−09 BRC24 TCGA−B6−A0IH−01A−11D−A10Y−09 TCGA−A8−A09W−01A−11W−A019−09 BR−M−150 TCGA−D8−A146−01A−31D−A10Y−09 TCGA−A2−A04N−01A−11D−A10Y−09 TCGA−D8−A1XF−01A−11D−A14G−09 TCGA−A2−A0YD−01A−11D−A10G−09 CSB16 TCGA−AR−A24M−01A−11D−A167−09 TCGA−A8−A06Y−01A−21W−A019−09 SA071 CGP_donor_1163909 BR−V−026 CGP_donor_1163918 TCGA−A2−A25B−01A−11D−A167−09 SA106 BR−M−037 CGP_donor_1199104 BR−V−064 TCGA−AN−A04D−01A−21W−A050−09 TCGA−E2−A1IG−01A−11D−A142−09 TCGA−BH−A204−01A−11D−A159−09 CSB3 CGP_donor_1163904 TCGA−B6−A0I6−01A−11D−A128−09 TCGA−A8−A07C−01A−11D−A045−09 TCGA−E9−A1RG−01A−11D−A14G−09 TCGA−A8−A06N−01A−11W−A019−09 CGP_donor_1230756 BRC11 TCGA−AN−A0XW−01A−11D−A10G−09 TCGA−B6−A0IM−01A−11W−A050−09 TCGA−AN−A0AS−01A−11W−A019−09 TCGA−A8−A08Z−01A−21W−A019−09 TCGA−B6−A0WW−01A−11D−A10G−09 BRC21 TCGA−E9−A1RF−01A−11D−A159−09 BR−M−076 TCGA−A2−A25E−01A−11D−A167−09 CSB8 TCGA−AQ−A1H2−01A−11D−A13L−09 TCGA−A8−A0AB−01A−11W−A050−09 TCGA−A2−A25A−01A−12D−A16D−09 TCGA−BH−A0HB−01A−11W−A071−09 TCGA−AO−A03P−01A−11W−A019−09 CGP_donor_1163913 TCGA−E9−A22D−01A−11D−A159−09 TCGA−D8−A1Y1−01A−21D−A14K−09 TCGA−E2−A1LB−01A−11D−A142−09 TCGA−A8−A095−01A−11W−A019−09 SA031 TCGA−A8−A09D−01A−11W−A019−09 BRC5 BR−M−121 CGP_donor_1163903 BRC41 BR−V−044 TCGA−D8−A27F−01A−11D−A16D−09 TCGA−A8−A0A7−01A−11W−A019−09 BR−V−023 TCGA−BH−A18K−01A−11D−A12B−09 TCGA−E2−A1AZ−01A−11D−A12Q−09 TCGA−BH−A0DX−01A−11D−A10Y−09 CGP_donor_1163915 TCGA−BH−A0C1−01B−11D−A12B−09 TCGA−A2−A0EO−01A−11W−A050−09 CGP_donor_1212378 BR−V−054 TCGA−BH−A0BZ−01A−31D−A12Q−09 CGP_donor_1234117 TCGA−EW−A1OV−01A−11D−A142−09 TCGA−BH−A0BV−01A−11W−A019−09 TCGA−A8−A06R−01A−11D−A015−09 TCGA−E9−A228−01A−31D−A159−09 TCGA−E2−A1B5−01A−21D−A12Q−09 TCGA−A8−A076−01A−21W−A019−09 BR−M−036 TCGA−E2−A10B−01A−11D−A10M−09 TCGA−BH−A0BD−01A−11W−A050−09 TCGA−B6−A0WZ−01A−11D−A10G−09 TCGA−AR−A24N−01A−11D−A167−09 TCGA−AN−A03Y−01A−21W−A019−09 TCGA−A2−A0SU−01A−11D−A099−09 CGP_donor_1212368 TCGA−E9−A1RC−01A−11D−A159−09 TCGA−E2−A1LL−01A−11D−A142−09 TCGA−BH−A0HP−01A−12D−A099−09 TCGA−B6−A0I8−01A−11W−A050−09 CGP_donor_1199105 TCGA−BH−A0DS−01A−11W−A071−09 BR−M−027 TCGA−E2−A1L9−01A−11D−A13L−09 TCGA−C8−A12T−01A−11D−A10Y−09 TCGA−A7−A26H−01A−11D−A167−09 TCGA−A1−A0SH−01A−11D−A099−09 TCGA−E9−A1RH−01A−21D−A167−09 TCGA−B6−A0WY−01A−11D−A10G−09 TCGA−A8−A08L−01A−11W−A019−09 TCGA−A8−A06U−01A−11W−A019−09 BRC50 BR−M−080 BR−M−026 CSB1 BRC39 TCGA−A2−A25D−01A−12D−A16D−09 SA220 SA218 SA210 CGP_donor_1199134 BRC42 TCGA−EW−A1J6−01A−11D−A188−09 TCGA−E2−A1IJ−01A−11D−A142−09 TCGA−E2−A1IE−01A−11D−A188−09 TCGA−B6−A0RV−01A−11D−A099−09 TCGA−B6−A0RL−01A−11D−A099−09 TCGA−AR−A255−01A−11D−A167−09 TCGA−AO−A1KT−01A−11D−A13L−09 TCGA−AO−A0JM−01A−21W−A071−09 TCGA−A8−A07P−01A−11W−A019−09 TCGA−A8−A07E−01A−11W−A050−09 TCGA−A8−A06X−01A−21W−A019−09 TCGA−A2−A0YK−01A−22D−A117−09 TCGA−A2−A0T7−01A−21D−A099−09 SA052 CGP_donor_1195182 BR−M−191 BR−M−105 CGP_donor_1230733 TCGA−EW−A1PB−01A−11D−A142−09 TCGA−E2−A1IN−01A−11D−A13L−09 TCGA−D8−A1J9−01A−11D−A13L−09 TCGA−AO−A129−01A−21D−A10M−09 TCGA−A8−A06O−01A−11W−A019−09 TCGA−A2−A0EY−01A−11W−A050−09 TCGA−A2−A0CX−01A−21W−A019−09 TCGA−A1−A0SI−01A−11D−A142−09 CGP_donor_1329919 CGP_donor_1234112 CGP_donor_1199074 BRC16 BR−V−036 TCGA−EW−A1P4−01A−21D−A142−09 TCGA−E9−A243−01A−21D−A167−09 TCGA−E9−A226−01A−21D−A159−09 TCGA−E2−A159−01A−11D−A10Y−09 TCGA−E2−A155−01A−11D−A12B−09 TCGA−E2−A152−01A−11D−A12B−09 TCGA−E2−A14Y−01A−21D−A12B−09 TCGA−E2−A14R−01A−11D−A10Y−09 TCGA−E2−A14P−01A−31D−A12B−09 TCGA−D8−A1Y3−01A−11D−A159−09 TCGA−D8−A1JJ−01A−31D−A14K−09 TCGA−D8−A1JG−01B−11D−A13L−09 TCGA−D8−A143−01A−11D−A10Y−09 TCGA−C8−A27B−01A−11D−A167−09 TCGA−C8−A27A−01A−11D−A167−09 TCGA−C8−A26W−01A−11D−A16D−09 TCGA−C8−A1HJ−01A−11D−A13L−09 TCGA−C8−A134−01A−11D−A10Y−09 TCGA−C8−A130−01A−31D−A10Y−09 TCGA−C8−A12W−01A−11D−A10Y−09 TCGA−BH−A208−01A−11D−A159−09 TCGA−BH−A1EV−01A−11D−A135−09 TCGA−BH−A18V−01A−11D−A12B−09 TCGA−BH−A18U−01A−21D−A12B−09 TCGA−BH−A0WA−01A−11D−A10G−09 TCGA−BH−A0BT−01A−11D−A12Q−09 TCGA−BH−A0BL−01A−11D−A10Y−09 TCGA−BH−A0AW−01A−11W−A071−09 TCGA−BH−A0AV−01A−31D−A10Y−09 TCGA−B6−A0X1−01A−11D−A10G−09 TCGA−B6−A0RE−01A−11W−A071−09 TCGA−AR−A256−01A−11D−A167−09 TCGA−AR−A1AJ−01A−21D−A12Q−09 TCGA−AR−A1AH−01A−11D−A12B−09 TCGA−AR−A0U4−01A−11D−A117−09 TCGA−AO−A0JE−01A−11W−A071−09 TCGA−AO−A0J4−01A−11W−A050−09 TCGA−AO−A0J2−01A−11W−A050−09 TCGA−AO−A03O−01A−11W−A019−09 TCGA−AN−A0XU−01A−11D−A10G−09 TCGA−AN−A0FX−01A−11W−A050−09 TCGA−AN−A0FT−01A−11W−A050−09 TCGA−AN−A0AL−01A−11W−A019−09 TCGA−A8−A07R−01A−21W−A050−09 TCGA−A8−A07O−01A−11W−A019−09 TCGA−A8−A07B−01A−11W−A019−09 TCGA−A7−A26I−01A−11D−A167−09 TCGA−A7−A0DA−01A−31D−A10Y−09 TCGA−A2−A0YM−01A−11D−A10G−09 TCGA−A2−A0YH−01A−11D−A10G−09 TCGA−A2−A0T1−01A−21D−A099−09 TCGA−A2−A0D1−01A−11W−A050−09 TCGA−A2−A04W−01A−31D−A10Y−09 TCGA−A1−A0SO−01A−22D−A099−09 SA227 SA226 SA097 SA092 SA084 CGP_donor_1310130 CGP_donor_1234118 CGP_donor_1230730 CGP_donor_1230727 CGP_donor_1212361 CGP_donor_1199135 CGP_donor_1199131 CGP_donor_1199101 CGP_donor_1187036 BRC47 BRC4 BRC20 BR−V−071 BR−V−060 BR−V−027 BR−V−012 BR−V−002 BR−M−085 BR−M−005 TCGA−EW−A1PH−01A−11D−A14K−09 TCGA−EW−A1PA−01A−11D−A142−09 TCGA−EW−A1OZ−01A−11D−A142−09 TCGA−EW−A1OY−01A−11D−A142−09 TCGA−E9−A244−01A−11D−A167−09 TCGA−E9−A22G−01A−11D−A159−09 TCGA−E9−A1RB−01A−11D−A17G−09 TCGA−E9−A1NF−01A−11D−A14G−09 TCGA−E9−A1ND−01A−11D−A142−09 TCGA−E9−A1N9−01A−11D−A14G−09 TCGA−E9−A1N8−01A−11D−A142−09 TCGA−E9−A1N5−01A−11D−A14G−09 TCGA−E2−A1LS−01A−12D−A159−09 TCGA−E2−A1LK−01A−21D−A14G−09 TCGA−E2−A1LH−01A−11D−A14G−09 TCGA−E2−A1L7−01A−11D−A142−09 TCGA−E2−A1IO−01A−11D−A142−09 TCGA−E2−A1II−01A−11D−A142−09 TCGA−E2−A1B6−01A−31D−A12Q−09 TCGA−E2−A1B0−01A−11D−A12Q−09 TCGA−E2−A15M−01A−11D−A12B−09 TCGA−E2−A15E−01A−11D−A12B−09 TCGA−E2−A158−01A−11D−A12B−09 TCGA−E2−A150−01A−11D−A12B−09 TCGA−E2−A14Z−01A−11D−A10Y−09 TCGA−E2−A14X−01A−11D−A10Y−09 TCGA−E2−A14N−01A−31D−A135−09 TCGA−E2−A109−01A−11D−A10M−09 TCGA−E2−A108−01A−13D−A10M−09 TCGA−D8−A27N−01A−11D−A16D−09 TCGA−D8−A27M−01A−11D−A16D−09 TCGA−D8−A27H−01A−11D−A16D−09 TCGA−D8−A1XZ−01A−11D−A14K−09 TCGA−D8−A1XW−01A−11D−A14K−09 TCGA−D8−A1XT−01A−11D−A14K−09 TCGA−D8−A1XL−01A−11D−A14K−09 TCGA−D8−A1XJ−01A−11D−A14K−09 TCGA−D8−A1XA−01A−11D−A14G−09 TCGA−D8−A1X5−01A−11D−A14G−09 TCGA−D8−A1JL−01A−11D−A13L−09 TCGA−D8−A1JK−01A−11D−A13L−09 TCGA−D8−A1JF−01A−11D−A13L−09 TCGA−D8−A147−01A−11D−A10Y−09 TCGA−D8−A142−01A−11D−A10Y−09 TCGA−D8−A13Z−01A−11D−A10Y−09 TCGA−D8−A13Y−01A−11D−A10Y−09 TCGA−C8−A278−01A−11D−A167−09 TCGA−C8−A275−01A−21D−A16D−09 TCGA−C8−A26X−01A−31D−A16D−09 TCGA−C8−A26V−01A−11D−A16D−09 TCGA−C8−A1HK−01A−21D−A13L−09 TCGA−C8−A1HG−01A−11D−A135−09 TCGA−C8−A1HF−01A−11D−A135−09 TCGA−C8−A138−01A−11D−A10Y−09 TCGA−C8−A135−01A−11D−A10Y−09 TCGA−C8−A131−01A−11D−A10Y−09 TCGA−C8−A12Z−01A−11D−A10Y−09 TCGA−C8−A12Q−01A−11D−A10Y−09 TCGA−C8−A12P−01A−11D−A10Y−09 TCGA−C8−A12O−01A−11D−A10Y−09 TCGA−C8−A12L−01A−11D−A10Y−09 TCGA−C8−A12K−01A−21D−A10Y−09 TCGA−BH−A202−01A−11D−A14K−09 TCGA−BH−A1FU−01A−11D−A14G−09 TCGA−BH−A1FN−01A−11D−A13L−09 TCGA−BH−A1FE−01A−11D−A13L−09 TCGA−BH−A1FD−01A−11W−A14Q−09 TCGA−BH−A1FC−01A−11D−A13L−09 TCGA−BH−A1F6−01A−11D−A13L−09 TCGA−BH−A1F0−01A−11D−A135−09 TCGA−BH−A1EY−01A−11D−A13L−09 TCGA−BH−A18T−01A−11D−A12B−09 TCGA−BH−A18Q−01A−12D−A12B−09 TCGA−BH−A18H−01A−11D−A12B−09 TCGA−BH−A0RX−01A−21D−A099−09 TCGA−BH−A0HY−01A−11W−A071−09 TCGA−BH−A0HX−01A−21W−A071−09 TCGA−BH−A0H7−01A−13W−A071−09 TCGA−BH−A0GY−01A−11W−A071−09 TCGA−BH−A0E6−01A−11W−A050−09 TCGA−BH−A0E0−01A−11W−A071−09 TCGA−BH−A0DL−01A−11D−A10Y−09 TCGA−BH−A0DI−01A−21D−A12Q−09 TCGA−BH−A0C3−01A−21D−A12Q−09 TCGA−BH−A0C0−01A−21W−A071−09 TCGA−BH−A0BR−01A−21W−A12T−09 TCGA−BH−A0BP−01A−11D−A10Y−09 TCGA−BH−A0BG−01A−11D−A10Y−09 TCGA−BH−A0BF−01A−21D−A12Q−09 TCGA−BH−A0BC−01A−22D−A099−09 TCGA−BH−A0B9−01A−11W−A071−09 TCGA−BH−A0B7−01A−12D−A10Y−09 TCGA−BH−A0B3−01A−11W−A071−09 TCGA−BH−A0B0−01A−21D−A10Y−09 TCGA−B6−A1KN−01A−11D−A13L−09 TCGA−B6−A0WX−01A−11D−A10G−09 TCGA−B6−A0RU−01A−11D−A099−09 TCGA−B6−A0RS−01A−11D−A099−09 TCGA−B6−A0RH−01A−21D−A10Y−09 TCGA−B6−A0IQ−01A−11W−A050−09 TCGA−B6−A0IK−01A−12W−A071−09 TCGA−B6−A0IJ−01A−11W−A050−09 TCGA−B6−A0IE−01A−11W−A050−09 TCGA−B6−A0I9−01A−11W−A050−09 TCGA−B6−A0I2−01A−11W−A050−09 TCGA−AR−A254−01A−21D−A167−09 TCGA−AR−A24S−01A−11D−A167−09 TCGA−AR−A24Q−01A−12D−A167−09 TCGA−AR−A24P−01A−11D−A167−09 TCGA−AR−A24K−01A−11D−A167−09 TCGA−AR−A1AY−01A−21D−A12Q−09 TCGA−AR−A1AW−01A−21D−A12Q−09 TCGA−AR−A1AS−01A−11D−A12Q−09 TCGA−AR−A1AQ−01A−11D−A12Q−09 TCGA−AR−A1AP−01A−11D−A12Q−09 TCGA−AR−A1AN−01A−11D−A12Q−09 TCGA−AR−A1AI−01A−11D−A12Q−09 TCGA−AR−A0U3−01A−11D−A10G−09 TCGA−AR−A0U2−01A−11D−A10G−09 TCGA−AR−A0U1−01A−11D−A10Y−09 TCGA−AR−A0U0−01A−11D−A10G−09 TCGA−AR−A0TV−01A−21D−A099−09 TCGA−AR−A0TS−01A−11D−A10Y−09 TCGA−AR−A0TP−01A−11D−A099−09 TCGA−AQ−A04L−01B−21D−A10M−09 TCGA−AQ−A04J−01A−02W−A050−09 TCGA−AQ−A04H−01B−11D−A10M−09 TCGA−AO−A12G−01A−11D−A10M−09 TCGA−AO−A12D−01A−11D−A10Y−09 TCGA−AO−A124−01A−11D−A10M−09 TCGA−AO−A0JL−01A−11W−A071−09 TCGA−AO−A0JD−01A−11W−A071−09 TCGA−AO−A0JB−01A−11W−A071−09 TCGA−AO−A0J6−01A−11W−A050−09 TCGA−AO−A03V−01A−11D−A10Y−09 TCGA−AO−A03R−01A−21W−A050−09 TCGA−AO−A03N−01B−11D−A10M−09 TCGA−AO−A03L−01A−41W−A071−09 TCGA−AN−A0XT−01A−11D−A10G−09 TCGA−AN−A0XN−01A−21D−A10G−09 TCGA−AN−A0G0−01A−11W−A050−09 TCGA−AN−A0FY−01A−11W−A050−09 TCGA−AN−A0FV−01A−11W−A019−09 TCGA−AN−A0FL−01A−11W−A050−09 TCGA−AN−A0FJ−01A−11W−A019−09 TCGA−AN−A0AR−01A−11W−A019−09 TCGA−AN−A0AJ−01A−11W−A019−09 TCGA−AN−A04C−01A−21W−A050−09 TCGA−A8−A09X−01A−11W−A019−09 TCGA−A8−A09Q−01A−11W−A019−09 TCGA−A8−A09N−01A−11W−A019−09 TCGA−A8−A097−01A−11W−A050−09 TCGA−A8−A092−01A−11W−A019−09 TCGA−A8−A08X−01A−21W−A019−09 TCGA−A8−A08R−01A−11W−A050−09 TCGA−A8−A08P−01A−11W−A019−09 TCGA−A8−A08I−01A−11W−A019−09 TCGA−A8−A084−01A−21W−A019−09 TCGA−A8−A081−01A−11W−A019−09 TCGA−A8−A07W−01A−11W−A019−09 TCGA−A8−A07U−01A−11W−A050−09 TCGA−A8−A079−01A−21W−A019−09 TCGA−A8−A075−01A−11D−A099−09 TCGA−A8−A06Q−01A−11W−A050−09 TCGA−A7−A26G−01A−21D−A167−09 TCGA−A7−A26F−01A−21D−A167−09 TCGA−A7−A13D−01A−13D−A12Q−09 TCGA−A7−A0CJ−01A−21W−A019−09 TCGA−A7−A0CE−01A−11W−A019−09 TCGA−A2−A1G1−01A−21D−A13L−09 TCGA−A2−A0YT−01A−11D−A10G−09 TCGA−A2−A0YJ−01A−11D−A10G−09 TCGA−A2−A0YG−01A−21D−A10G−09 TCGA−A2−A0T3−01A−21D−A10Y−09 TCGA−A2−A0T2−01A−11W−A097−09 TCGA−A2−A0SX−01A−12D−A099−09 TCGA−A2−A0SW−01A−11D−A099−09 TCGA−A2−A0SV−01A−11D−A099−09 TCGA−A2−A0EQ−01A−11W−A050−09 TCGA−A2−A0D2−01A−21W−A050−09 TCGA−A2−A0D0−01A−11W−A019−09 TCGA−A2−A0CW−01A−21D−A10Y−09 TCGA−A2−A0CM−01A−31W−A050−09 TCGA−A2−A04U−01A−11D−A10Y−09 TCGA−A2−A04P−01A−31D−A128−09 TCGA−A1−A0SP−01A−11D−A099−09 TCGA−A1−A0SK−01A−12D−A099−09 SA236 SA234 SA228 SA219 SA217 SA214 SA213 SA212 SA102 SA101 SA094 SA093 SA089 SA080 SA077 SA076 SA075 SA074 SA073 SA072 SA069 SA067 SA065 SA063 SA056 SA053 SA051 SA030 SA018 CSB9 CSB33 CSB24 CSB15 CGP_donor_1329921 CGP_donor_1329917 CGP_donor_1234116 CGP_donor_1234111 CGP_donor_1230782 CGP_donor_1212376 CGP_donor_1212374 CGP_donor_1212371 CGP_donor_1212364 CGP_donor_1212360 CGP_donor_1199129 CGP_donor_1199128 CGP_donor_1199106 CGP_donor_1199103 CGP_donor_1199100 CGP_donor_1195183 CGP_donor_1187027 CGP_donor_1184343 CGP_donor_1163917 CGP_donor_1163906 CGP_donor_1163902 CGP_donor_1163901 CGP_donor_1163900 BRC51 BRC44 BRC37 BRC31 BRC29 BRC13 BR−V−067 BR−V−051 BR−V−050 BR−V−045 BR−V−043 BR−V−037 BR−V−033 BR−V−024 BR−V−022 BR−V−014 BR−V−008 BR−V−007 BR−M−192 BR−M−189 BR−M−166 BR−M−123 BR−M−122 BR−M−095 BR−M−094 BR−M−073 BR−M−045 BR−M−034 BB28T

unknown CG mut

known HCG mut

wt

SYNE1 SYNE2 ATR SYCP2 STAG2 BRCA1 DIDO1 STAG1 SMC1A HIST2H2BE RAD21 REC8 HIST1H2AJ HIST1H2BC HIST1H2BD HIST1H4L HSPA2 SMC1B SMC3 TERF2 ACD H2AFZ HIST1H2AC HIST1H2AE HIST1H2BE HIST1H2BH LMNA LMNB1 STAG3 SUN1 SYCP1 TERF2IP HIST1H2BA HIST1H2BJ HIST1H2BK HIST1H2BM HIST1H4C HIST1H4D HIST1H4E HIST1H4J HIST2H2AC HIST3H3 POT1 FKBP6 H2AFX HIST1H2AB HIST1H2BB HIST1H2BF HIST1H2BG SYCE1

known HCG mut

wt

Integrins In Angiogenesis FDR = 7e−12%, FDR nod = 1.4% Meiotic Synapsis FDR = 7.3e−12%, FDR nod = 6.3e−10%

unknown CG mut

known HCG mut

wt

ATM BRCA2 TEX15 BRCA1 HIST1H3B MLH3 BLM HIST1H2BC HIST1H2BD HIST1H3G HIST2H2BE RAD50 SPO11 HIST1H2AJ HIST1H2BH HIST1H4L MSH5 RAD51 RAD51C RBBP8 CDK2 H2AFZ HIST1H2AC HIST1H2AE HIST1H2BE HIST1H2BJ HIST1H3C HIST1H3I HIST1H4E MLH1 MRE11A RPA3 TOP3A CDK4 DMC1 H2AFX HIST1H2BA HIST1H2BF HIST1H2BG HIST1H2BK HIST1H2BM HIST1H3D HIST1H3F HIST1H3J HIST1H4C HIST1H4D HIST1H4J HIST2H2AC HIST3H3 MND1 MSH4 NBN PRDM9 HIST1H2AB HIST1H2BB HIST1H3A HIST1H3H HIST2H3D RPA1 RPA2 unknown CG mut

known HCG mut

wt TP53 ATM ATR HERC2 BRCA1 MDC1 UBC BRIP1 HIST1H2BC HIST2H2BE TOPBP1 BLM HIST1H2BD RFC4 TP53BP1 BRE CDK2 CHEK2 CLSPN HIST1H2BE HIST1H4L PIAS4 RAD17 RAD50 RFC5 RNF168 WHSC1 BARD1 BRCC3 CCNA2 DNA2 EXO1 H2AFX HIST1H2BA HIST1H2BG HIST1H2BH HIST1H2BJ HIST1H2BM HIST1H4C HIST1H4D HIST1H4E HIST1H4J MRE11A NBN PPP4C RAD1 RAD9A RBBP8 RFC2 RHNO1 RMI1 RPA1 RPA3 UBA52 BABAM1 HIST1H2BB HIST1H2BF HIST1H2BK HIST3H3 HUS1 PPP4R2 RPA2 SUMO1 SUMO2 TIMELESS TIPIN TOP3A UBE2V2 UIMC1 WRN

unknown CG mut

known HCG mut

wt

TP53 ATM ATR HERC2 BRCA1 MDC1 UBC BRIP1 HIST1H2BC HIST2H2BE TOPBP1 BLM HIST1H2BD RFC4 TP53BP1 BRE CDK2 CHEK2 CLSPN HIST1H2BE HIST1H4L PIAS4 RAD17 RAD50 RFC5 RNF168 WHSC1 BARD1 BRCC3 CCNA2 DNA2 EXO1 H2AFX HIST1H2BA HIST1H2BG HIST1H2BH HIST1H2BJ HIST1H2BM HIST1H4C HIST1H4D HIST1H4E HIST1H4J MRE11A NBN PPP4C RAD1 RAD9A RBBP8 RFC2 RHNO1 RMI1 RPA1 RPA3 UBA52 BABAM1 HIST1H2BB HIST1H2BF HIST1H2BK HIST3H3 HUS1 PPP4R2 RPA2 SUMO1 SUMO2 TIMELESS TIPIN TOP3A UBE2V2 UIMC1 WRN

SA054 CSB16 TCGA−AR−A24M−01A−11D−A167−09 TCGA−AO−A03T−01A−21W−A050−09 TCGA−A8−A06Y−01A−21W−A019−09 SA071 CGP_donor_1163909 BR−V−026 CGP_donor_1163918 SA106 TCGA−BH−A0DS−01A−11W−A071−09 CGP_donor_1199104 CGP_donor_1310129 BR−V−064 BRC33 TCGA−BH−A204−01A−11D−A159−09 TCGA−B6−A0WY−01A−11D−A10G−09 TCGA−A8−A08L−01A−11W−A019−09 TCGA−E9−A1RF−01A−11D−A159−09 BR−M−076 CGP_donor_1212368 TCGA−A2−A25B−01A−11D−A167−09 BRC39 BR−M−037 TCGA−A2−A25E−01A−11D−A167−09 CSB8 TCGA−B6−A0IB−01A−11W−A050−09 TCGA−A1−A0SF−01A−11D−A142−09 TCGA−AO−A03P−01A−11W−A019−09 CGP_donor_1163913 TCGA−A8−A09A−01A−11W−A019−09 BR−V−040 TCGA−E9−A1NA−01A−11D−A142−09 BR−M−047 CGP_donor_1163903 BRC41 BR−V−044 TCGA−E2−A1LG−01A−21D−A14K−09 CGP_donor_1234119 BR−M−098 TCGA−D8−A1Y1−01A−21D−A14K−09 TCGA−B6−A0RO−01A−22D−A099−09 TCGA−AR−A24X−01A−11D−A167−09 CSB1 TCGA−AN−A0XW−01A−11D−A10G−09 TCGA−B6−A0IM−01A−11W−A050−09 BR−M−027 TCGA−BH−A0C1−01B−11D−A12B−09 TCGA−A2−A0EO−01A−11W−A050−09 CGP_donor_1212378 BR−V−054 CGP_donor_1234117 TCGA−EW−A1OV−01A−11D−A142−09 TCGA−BH−A0BZ−01A−31D−A12Q−09 TCGA−BH−A0BV−01A−11W−A019−09 TCGA−BH−A1FJ−01A−11D−A13L−09 TCGA−BH−A0W4−01A−11D−A10G−09 TCGA−BH−A0B5−01A−11D−A12Q−09 TCGA−AQ−A1H3−01A−31D−A13L−09 TCGA−A2−A0CS−01A−11D−A10Y−09 CGP_donor_1212369 BRC18 TCGA−A8−A07E−01A−11W−A050−09 BR−M−191 TCGA−EW−A1J6−01A−11D−A188−09 TCGA−E2−A1IJ−01A−11D−A142−09 TCGA−E2−A1IE−01A−11D−A188−09 TCGA−B6−A0RV−01A−11D−A099−09 TCGA−B6−A0RL−01A−11D−A099−09 TCGA−AR−A255−01A−11D−A167−09 TCGA−AO−A1KT−01A−11D−A13L−09 TCGA−AO−A0JM−01A−21W−A071−09 TCGA−A8−A07P−01A−11W−A019−09 TCGA−A8−A06X−01A−21W−A019−09 TCGA−A2−A0YK−01A−22D−A117−09 TCGA−A2−A0T7−01A−21D−A099−09 SA052 CGP_donor_1195182 BR−M−105 CGP_donor_1329919 CGP_donor_1310130 TCGA−EW−A1PB−01A−11D−A142−09 TCGA−E2−A1LH−01A−11D−A14G−09 TCGA−E2−A159−01A−11D−A10Y−09 TCGA−E2−A152−01A−11D−A12B−09 TCGA−D8−A1JJ−01A−31D−A14K−09 TCGA−D8−A1J9−01A−11D−A13L−09 TCGA−C8−A12W−01A−11D−A10Y−09 TCGA−BH−A18U−01A−21D−A12B−09 TCGA−AR−A24S−01A−11D−A167−09 TCGA−AO−A129−01A−21D−A10M−09 TCGA−A8−A09Q−01A−11W−A019−09 TCGA−A8−A092−01A−11W−A019−09 TCGA−A8−A07O−01A−11W−A019−09 TCGA−A8−A07B−01A−11W−A019−09 TCGA−A7−A0DA−01A−31D−A10Y−09 TCGA−A2−A0YM−01A−11D−A10G−09 TCGA−A2−A0YH−01A−11D−A10G−09 TCGA−A2−A0T1−01A−21D−A099−09 TCGA−A2−A0EY−01A−11W−A050−09 CGP_donor_1234118 CGP_donor_1234112 CGP_donor_1230733 CGP_donor_1230727 CGP_donor_1212361 CGP_donor_1199101 CGP_donor_1199074 CGP_donor_1187036 CGP_donor_1163902 BRC4 BRC20 BR−V−060 BR−M−166 TCGA−EW−A1PH−01A−11D−A14K−09 TCGA−EW−A1PA−01A−11D−A142−09 TCGA−EW−A1P4−01A−21D−A142−09 TCGA−EW−A1OZ−01A−11D−A142−09 TCGA−EW−A1OY−01A−11D−A142−09 TCGA−E9−A244−01A−11D−A167−09 TCGA−E9−A243−01A−21D−A167−09 TCGA−E9−A22G−01A−11D−A159−09 TCGA−E9−A226−01A−21D−A159−09 TCGA−E9−A1RB−01A−11D−A17G−09 TCGA−E9−A1NF−01A−11D−A14G−09 TCGA−E9−A1ND−01A−11D−A142−09 TCGA−E9−A1N9−01A−11D−A14G−09 TCGA−E9−A1N8−01A−11D−A142−09 TCGA−E9−A1N5−01A−11D−A14G−09 TCGA−E2−A1LS−01A−12D−A159−09 TCGA−E2−A1LK−01A−21D−A14G−09 TCGA−E2−A1L7−01A−11D−A142−09 TCGA−E2−A1IO−01A−11D−A142−09 TCGA−E2−A1IN−01A−11D−A13L−09 TCGA−E2−A1II−01A−11D−A142−09 TCGA−E2−A1B6−01A−31D−A12Q−09 TCGA−E2−A1B0−01A−11D−A12Q−09 TCGA−E2−A15M−01A−11D−A12B−09 TCGA−E2−A15E−01A−11D−A12B−09 TCGA−E2−A158−01A−11D−A12B−09 TCGA−E2−A155−01A−11D−A12B−09 TCGA−E2−A150−01A−11D−A12B−09 TCGA−E2−A14Z−01A−11D−A10Y−09 TCGA−E2−A14Y−01A−21D−A12B−09 TCGA−E2−A14X−01A−11D−A10Y−09 TCGA−E2−A14R−01A−11D−A10Y−09 TCGA−E2−A14P−01A−31D−A12B−09 TCGA−E2−A14N−01A−31D−A135−09 TCGA−E2−A109−01A−11D−A10M−09 TCGA−E2−A108−01A−13D−A10M−09 TCGA−D8−A27N−01A−11D−A16D−09 TCGA−D8−A27M−01A−11D−A16D−09 TCGA−D8−A27H−01A−11D−A16D−09 TCGA−D8−A1Y3−01A−11D−A159−09 TCGA−D8−A1XZ−01A−11D−A14K−09 TCGA−D8−A1XW−01A−11D−A14K−09 TCGA−D8−A1XT−01A−11D−A14K−09 TCGA−D8−A1XL−01A−11D−A14K−09 TCGA−D8−A1XJ−01A−11D−A14K−09 TCGA−D8−A1XA−01A−11D−A14G−09 TCGA−D8−A1X5−01A−11D−A14G−09 TCGA−D8−A1JL−01A−11D−A13L−09 TCGA−D8−A1JK−01A−11D−A13L−09 TCGA−D8−A1JG−01B−11D−A13L−09 TCGA−D8−A1JF−01A−11D−A13L−09 TCGA−D8−A147−01A−11D−A10Y−09 TCGA−D8−A143−01A−11D−A10Y−09 TCGA−D8−A142−01A−11D−A10Y−09 TCGA−D8−A13Z−01A−11D−A10Y−09 TCGA−D8−A13Y−01A−11D−A10Y−09 TCGA−C8−A27B−01A−11D−A167−09 TCGA−C8−A27A−01A−11D−A167−09 TCGA−C8−A278−01A−11D−A167−09 TCGA−C8−A275−01A−21D−A16D−09 TCGA−C8−A26X−01A−31D−A16D−09 TCGA−C8−A26W−01A−11D−A16D−09 TCGA−C8−A26V−01A−11D−A16D−09 TCGA−C8−A1HK−01A−21D−A13L−09 TCGA−C8−A1HJ−01A−11D−A13L−09 TCGA−C8−A1HG−01A−11D−A135−09 TCGA−C8−A1HF−01A−11D−A135−09 TCGA−C8−A138−01A−11D−A10Y−09 TCGA−C8−A135−01A−11D−A10Y−09 TCGA−C8−A134−01A−11D−A10Y−09 TCGA−C8−A131−01A−11D−A10Y−09 TCGA−C8−A130−01A−31D−A10Y−09 TCGA−C8−A12Z−01A−11D−A10Y−09 TCGA−C8−A12Q−01A−11D−A10Y−09 TCGA−C8−A12P−01A−11D−A10Y−09 TCGA−C8−A12O−01A−11D−A10Y−09 TCGA−C8−A12L−01A−11D−A10Y−09 TCGA−C8−A12K−01A−21D−A10Y−09 TCGA−BH−A208−01A−11D−A159−09 TCGA−BH−A202−01A−11D−A14K−09 TCGA−BH−A1FU−01A−11D−A14G−09 TCGA−BH−A1FN−01A−11D−A13L−09 TCGA−BH−A1FE−01A−11D−A13L−09 TCGA−BH−A1FD−01A−11W−A14Q−09 TCGA−BH−A1FC−01A−11D−A13L−09 TCGA−BH−A1F6−01A−11D−A13L−09 TCGA−BH−A1F0−01A−11D−A135−09 TCGA−BH−A1EY−01A−11D−A13L−09 TCGA−BH−A1EV−01A−11D−A135−09 TCGA−BH−A18V−01A−11D−A12B−09 TCGA−BH−A18T−01A−11D−A12B−09 TCGA−BH−A18Q−01A−12D−A12B−09 TCGA−BH−A18H−01A−11D−A12B−09 TCGA−BH−A0WA−01A−11D−A10G−09 TCGA−BH−A0RX−01A−21D−A099−09 TCGA−BH−A0HY−01A−11W−A071−09 TCGA−BH−A0HX−01A−21W−A071−09 TCGA−BH−A0H7−01A−13W−A071−09 TCGA−BH−A0GY−01A−11W−A071−09 TCGA−BH−A0E6−01A−11W−A050−09 TCGA−BH−A0E0−01A−11W−A071−09 TCGA−BH−A0DL−01A−11D−A10Y−09 TCGA−BH−A0DI−01A−21D−A12Q−09 TCGA−BH−A0C3−01A−21D−A12Q−09 TCGA−BH−A0C0−01A−21W−A071−09 TCGA−BH−A0BT−01A−11D−A12Q−09 TCGA−BH−A0BR−01A−21W−A12T−09 TCGA−BH−A0BP−01A−11D−A10Y−09 TCGA−BH−A0BL−01A−11D−A10Y−09 TCGA−BH−A0BG−01A−11D−A10Y−09 TCGA−BH−A0BF−01A−21D−A12Q−09 TCGA−BH−A0BC−01A−22D−A099−09 TCGA−BH−A0B9−01A−11W−A071−09 TCGA−BH−A0B7−01A−12D−A10Y−09 TCGA−BH−A0B3−01A−11W−A071−09 TCGA−BH−A0B0−01A−21D−A10Y−09 TCGA−BH−A0AW−01A−11W−A071−09 TCGA−BH−A0AV−01A−31D−A10Y−09 TCGA−B6−A1KN−01A−11D−A13L−09 TCGA−B6−A0X1−01A−11D−A10G−09 TCGA−B6−A0WX−01A−11D−A10G−09 TCGA−B6−A0RU−01A−11D−A099−09 TCGA−B6−A0RS−01A−11D−A099−09 TCGA−B6−A0RH−01A−21D−A10Y−09 TCGA−B6−A0RE−01A−11W−A071−09 TCGA−B6−A0IQ−01A−11W−A050−09 TCGA−B6−A0IK−01A−12W−A071−09 TCGA−B6−A0IJ−01A−11W−A050−09 TCGA−B6−A0IE−01A−11W−A050−09 TCGA−B6−A0I9−01A−11W−A050−09 TCGA−B6−A0I2−01A−11W−A050−09 TCGA−AR−A256−01A−11D−A167−09 TCGA−AR−A254−01A−21D−A167−09 TCGA−AR−A24Q−01A−12D−A167−09 TCGA−AR−A24P−01A−11D−A167−09 TCGA−AR−A24K−01A−11D−A167−09 TCGA−AR−A1AY−01A−21D−A12Q−09 TCGA−AR−A1AW−01A−21D−A12Q−09 TCGA−AR−A1AS−01A−11D−A12Q−09 TCGA−AR−A1AQ−01A−11D−A12Q−09 TCGA−AR−A1AP−01A−11D−A12Q−09 TCGA−AR−A1AN−01A−11D−A12Q−09 TCGA−AR−A1AJ−01A−21D−A12Q−09 TCGA−AR−A1AI−01A−11D−A12Q−09 TCGA−AR−A1AH−01A−11D−A12B−09 TCGA−AR−A0U4−01A−11D−A117−09 TCGA−AR−A0U3−01A−11D−A10G−09 TCGA−AR−A0U2−01A−11D−A10G−09 TCGA−AR−A0U1−01A−11D−A10Y−09 TCGA−AR−A0U0−01A−11D−A10G−09 TCGA−AR−A0TV−01A−21D−A099−09 TCGA−AR−A0TS−01A−11D−A10Y−09 TCGA−AR−A0TP−01A−11D−A099−09 TCGA−AQ−A04L−01B−21D−A10M−09 TCGA−AQ−A04J−01A−02W−A050−09 TCGA−AQ−A04H−01B−11D−A10M−09 TCGA−AO−A12G−01A−11D−A10M−09 TCGA−AO−A12D−01A−11D−A10Y−09 TCGA−AO−A124−01A−11D−A10M−09 TCGA−AO−A0JL−01A−11W−A071−09 TCGA−AO−A0JE−01A−11W−A071−09 TCGA−AO−A0JD−01A−11W−A071−09 TCGA−AO−A0JB−01A−11W−A071−09 TCGA−AO−A0J6−01A−11W−A050−09 TCGA−AO−A0J4−01A−11W−A050−09 TCGA−AO−A0J2−01A−11W−A050−09 TCGA−AO−A03V−01A−11D−A10Y−09 TCGA−AO−A03R−01A−21W−A050−09 TCGA−AO−A03O−01A−11W−A019−09 TCGA−AO−A03N−01B−11D−A10M−09 TCGA−AO−A03L−01A−41W−A071−09 TCGA−AN−A0XU−01A−11D−A10G−09 TCGA−AN−A0XT−01A−11D−A10G−09 TCGA−AN−A0XN−01A−21D−A10G−09 TCGA−AN−A0G0−01A−11W−A050−09 TCGA−AN−A0FY−01A−11W−A050−09 TCGA−AN−A0FX−01A−11W−A050−09 TCGA−AN−A0FV−01A−11W−A019−09 TCGA−AN−A0FT−01A−11W−A050−09 TCGA−AN−A0FL−01A−11W−A050−09 TCGA−AN−A0FJ−01A−11W−A019−09 TCGA−AN−A0AR−01A−11W−A019−09 TCGA−AN−A0AL−01A−11W−A019−09 TCGA−AN−A0AJ−01A−11W−A019−09 TCGA−AN−A04C−01A−21W−A050−09 TCGA−A8−A09X−01A−11W−A019−09 TCGA−A8−A09N−01A−11W−A019−09 TCGA−A8−A097−01A−11W−A050−09 TCGA−A8−A08X−01A−21W−A019−09 TCGA−A8−A08R−01A−11W−A050−09 TCGA−A8−A08P−01A−11W−A019−09 TCGA−A8−A08I−01A−11W−A019−09 TCGA−A8−A084−01A−21W−A019−09 TCGA−A8−A081−01A−11W−A019−09 TCGA−A8−A07W−01A−11W−A019−09 TCGA−A8−A07U−01A−11W−A050−09 TCGA−A8−A07R−01A−21W−A050−09 TCGA−A8−A079−01A−21W−A019−09 TCGA−A8−A075−01A−11D−A099−09 TCGA−A8−A06Q−01A−11W−A050−09 TCGA−A8−A06O−01A−11W−A019−09 TCGA−A7−A26I−01A−11D−A167−09 TCGA−A7−A26G−01A−21D−A167−09 TCGA−A7−A26F−01A−21D−A167−09 TCGA−A7−A13D−01A−13D−A12Q−09 TCGA−A7−A0CJ−01A−21W−A019−09 TCGA−A7−A0CE−01A−11W−A019−09 TCGA−A2−A1G1−01A−21D−A13L−09 TCGA−A2−A0YT−01A−11D−A10G−09 TCGA−A2−A0YJ−01A−11D−A10G−09 TCGA−A2−A0YG−01A−21D−A10G−09 TCGA−A2−A0T3−01A−21D−A10Y−09 TCGA−A2−A0T2−01A−11W−A097−09 TCGA−A2−A0SX−01A−12D−A099−09 TCGA−A2−A0SW−01A−11D−A099−09 TCGA−A2−A0SV−01A−11D−A099−09 TCGA−A2−A0EQ−01A−11W−A050−09 TCGA−A2−A0D2−01A−21W−A050−09 TCGA−A2−A0D1−01A−11W−A050−09 TCGA−A2−A0D0−01A−11W−A019−09 TCGA−A2−A0CX−01A−21W−A019−09 TCGA−A2−A0CW−01A−21D−A10Y−09 TCGA−A2−A0CM−01A−31W−A050−09 TCGA−A2−A04W−01A−31D−A10Y−09 TCGA−A2−A04U−01A−11D−A10Y−09 TCGA−A2−A04P−01A−31D−A128−09 TCGA−A1−A0SP−01A−11D−A099−09 TCGA−A1−A0SO−01A−22D−A099−09 TCGA−A1−A0SK−01A−12D−A099−09 TCGA−A1−A0SI−01A−11D−A142−09 SA236 SA234 SA228 SA227 SA226 SA219 SA217 SA214 SA213 SA212 SA102 SA101 SA097 SA094 SA093 SA092 SA089 SA084 SA080 SA077 SA076 SA075 SA074 SA073 SA072 SA069 SA067 SA065 SA063 SA056 SA053 SA051 SA030 SA018 CSB9 CSB33 CSB24 CSB15 CGP_donor_1329921 CGP_donor_1329917 CGP_donor_1234116 CGP_donor_1234111 CGP_donor_1230782 CGP_donor_1230730 CGP_donor_1212376 CGP_donor_1212374 CGP_donor_1212371 CGP_donor_1212364 CGP_donor_1212360 CGP_donor_1199135 CGP_donor_1199131 CGP_donor_1199129 CGP_donor_1199128 CGP_donor_1199106 CGP_donor_1199103 CGP_donor_1199100 CGP_donor_1195183 CGP_donor_1187027 CGP_donor_1184343 CGP_donor_1163917 CGP_donor_1163906 CGP_donor_1163901 CGP_donor_1163900 BRC51 BRC47 BRC44 BRC37 BRC31 BRC29 BRC16 BRC13 BR−V−071 BR−V−067 BR−V−051 BR−V−050 BR−V−045 BR−V−043 BR−V−037 BR−V−036 BR−V−033 BR−V−027 BR−V−024 BR−V−022 BR−V−014 BR−V−012 BR−V−008 BR−V−007 BR−V−002 BR−M−192 BR−M−189 BR−M−123 BR−M−122 BR−M−095 BR−M−094 BR−M−085 BR−M−073 BR−M−045 BR−M−034 BR−M−005 BB28T


Meiotic Recombination FDR = 8.1e−12%, FDR nod = 3.6e−06% G2/M DNA Damage Checkpoint Processing Of DNA Double Strand Break Ends FDR = 7e−12%, FDR nod = 1.1%

unknown CG mut TP53 ATM CDKN1B HIST1H2BC HIST2H2BE RAD50 EP400 HIST1H2AJ HIST1H2BD ACD CCNE1 CDK2 H2AFZ HIST1H2BE HIST1H2BG HIST1H2BJ HIST1H4L TERF2IP CCNA2 CCNE2 H2AFX HIST1H2AC HIST1H2BA HIST1H2BB HIST1H2BH HIST1H2BM HIST1H4C HIST1H4D HIST1H4E HIST1H4J HIST2H2AC MRE11A NBN HIST1H2AB HIST1H2AE HIST1H2BF HIST1H2BK HIST3H3 POT1 TERF2

G2/M DNA Damage Checkpoint Processing Of DNA Double Strand Break Ends FDR = 7e−12%, FDR nod = 1.1%

B TCGA−E9−A1NI−01A−11W−A16H−09 TCGA−D8−A1JN−01A−11D−A13L−09 TCGA−D8−A1JJ−01A−31D−A14K−09 TCGA−D8−A1JD−01A−11D−A13L−09 TCGA−BH−A1F8−01A−11D−A13L−09 TCGA−BH−A0W7−01A−11D−A10Y−09 TCGA−AC−A23C−01A−12D−A167−09 TCGA−A8−A07E−01A−11W−A050−09 TCGA−A8−A075−01A−11D−A099−09 SA214 CSB1 CGP_donor_1212366 CGP_donor_1212361 BRC7 BRC50 BRC3 BRC18 TCGA−E9−A1RA−01A−11D−A14G−09 TCGA−E2−A1IN−01A−11D−A13L−09 TCGA−E2−A15K−01A−11D−A12Q−09 TCGA−D8−A27P−01A−11D−A16D−09 TCGA−D8−A1XY−01A−11D−A14K−09 TCGA−D8−A1XM−01A−21D−A14K−09 TCGA−D8−A1JH−01A−11D−A188−09 TCGA−D8−A146−01A−31D−A10Y−09 TCGA−C8−A12Y−01A−11D−A12B−09 TCGA−C8−A12T−01A−11D−A10Y−09 TCGA−C8−A12L−01A−11D−A10Y−09 TCGA−BH−A1FE−01A−11D−A13L−09 TCGA−BH−A1EY−01A−11D−A13L−09 TCGA−BH−A18F−01A−11D−A12B−09 TCGA−BH−A0H9−01A−11W−A071−09 TCGA−BH−A0DK−01A−21W−A071−09 TCGA−B6−A0RP−01A−21D−A099−09 TCGA−AR−A24S−01A−11D−A167−09 TCGA−AR−A24M−01A−11D−A167−09 TCGA−AR−A24K−01A−11D−A167−09 TCGA−AR−A1AS−01A−11D−A12Q−09 TCGA−AO−A1KR−01A−12D−A142−09 TCGA−AN−A0FS−01A−11W−A050−09 TCGA−AN−A0AJ−01A−11W−A019−09 TCGA−AN−A03Y−01A−21W−A019−09 TCGA−A8−A0A7−01A−11W−A019−09 TCGA−A8−A095−01A−11W−A019−09 TCGA−A8−A093−01A−11W−A019−09 TCGA−A8−A092−01A−11W−A019−09 TCGA−A8−A08L−01A−11W−A019−09 TCGA−A8−A081−01A−11W−A019−09 TCGA−A7−A26H−01A−11D−A167−09 TCGA−A2−A0YL−01A−21D−A10G−09 TCGA−A2−A0YK−01A−22D−A117−09 TCGA−A2−A0T7−01A−21D−A099−09 TCGA−A2−A0EY−01A−11W−A050−09 TCGA−A2−A0EV−01A−11W−A050−09 TCGA−A2−A0CS−01A−11D−A10Y−09 TCGA−A2−A04N−01A−11D−A10Y−09 CGP_donor_1310130 CGP_donor_1234117 CGP_donor_1230733 CGP_donor_1212378 CGP_donor_1212369 CGP_donor_1212363 CGP_donor_1212360 CGP_donor_1187021 CGP_donor_1163903 BRC5 BRC4 BRC20 BRC13 BR−M−150 BR−M−116 BR−M−050 TCGA−EW−A1PE−01A−11D−A142−09 TCGA−EW−A1P0−01A−11D−A142−09 TCGA−EW−A1OV−01A−11D−A142−09 TCGA−EW−A1J2−01A−21D−A13L−09 TCGA−EW−A1J1−01A−11D−A188−09 TCGA−EW−A1IX−01A−12D−A142−09 TCGA−EW−A1IW−01A−11D−A13L−09 TCGA−E9−A295−01A−11D−A16D−09 TCGA−E9−A249−01A−11D−A167−09 TCGA−E9−A229−01A−31D−A17G−09 TCGA−E9−A227−01A−11D−A159−09 TCGA−E9−A226−01A−21D−A159−09 TCGA−E9−A1RI−01A−11D−A167−09 TCGA−E9−A1RE−01A−11D−A159−09 TCGA−E9−A1RD−01A−11D−A159−09 TCGA−E9−A1RC−01A−11D−A159−09 TCGA−E9−A1R5−01A−11D−A14K−09 TCGA−E9−A1R4−01A−21D−A14G−09 TCGA−E9−A1R3−01A−31D−A14K−09 TCGA−E9−A1R0−01A−22D−A16D−09 TCGA−E9−A1NH−01A−11D−A14G−09 TCGA−E9−A1NG−01A−21D−A14K−09 TCGA−E9−A1N5−01A−11D−A14G−09 TCGA−E2−A1L8−01A−11D−A13L−09 TCGA−E2−A1L6−01A−11D−A13L−09 TCGA−E2−A1IO−01A−11D−A142−09 TCGA−E2−A1IL−01A−11D−A14G−09 TCGA−E2−A1IF−01A−11D−A142−09 TCGA−E2−A1BD−01A−11D−A12Q−09 TCGA−E2−A1BC−01A−11D−A14G−09 TCGA−E2−A1B4−01A−11D−A12Q−09 TCGA−E2−A15P−01A−11D−A10Y−09 TCGA−E2−A15L−01A−11D−A12B−09 TCGA−E2−A15G−01A−11D−A12B−09 TCGA−E2−A15E−01A−11D−A12B−09 TCGA−E2−A15C−01A−31D−A12B−09 TCGA−E2−A156−01A−11D−A12B−09 TCGA−E2−A154−01A−11D−A10Y−09 TCGA−E2−A153−01A−12D−A12B−09 TCGA−E2−A14Y−01A−21D−A12B−09 TCGA−E2−A14V−01A−11D−A12B−09 TCGA−E2−A10F−01A−11D−A10M−09 TCGA−E2−A10B−01A−11D−A10M−09 TCGA−E2−A105−01A−11D−A10M−09 TCGA−D8−A27T−01A−11D−A16D−09 TCGA−D8−A27L−01A−11D−A16D−09 TCGA−D8−A1Y2−01A−11D−A159−09 TCGA−D8−A1Y1−01A−21D−A14K−09 TCGA−D8−A1XS−01A−11D−A14K−09 TCGA−D8−A1XO−01A−11D−A14K−09 TCGA−D8−A1XL−01A−11D−A14K−09 TCGA−D8−A1JU−01A−11D−A13L−09 TCGA−D8−A1JS−01A−11D−A13L−09 TCGA−D8−A1JP−01A−11D−A13L−09 TCGA−D8−A1JK−01A−11D−A13L−09 TCGA−D8−A1JF−01A−11D−A13L−09 TCGA−D8−A1JE−01A−11D−A13L−09 TCGA−D8−A143−01A−11D−A10Y−09 TCGA−C8−A278−01A−11D−A167−09 TCGA−C8−A274−01A−11D−A16D−09 TCGA−C8−A26X−01A−31D−A16D−09 TCGA−C8−A26W−01A−11D−A16D−09 TCGA−C8−A1HF−01A−11D−A135−09 TCGA−C8−A1HE−01A−11D−A188−09 TCGA−C8−A133−01A−32D−A12B−09 TCGA−C8−A131−01A−11D−A10Y−09 TCGA−C8−A130−01A−31D−A10Y−09 TCGA−C8−A12U−01A−11D−A10Y−09 TCGA−C8−A12N−01A−11D−A10Y−09 TCGA−BH−A208−01A−11D−A159−09 TCGA−BH−A203−01A−12D−A167−09 TCGA−BH−A202−01A−11D−A14K−09 TCGA−BH−A1EU−01A−11D−A135−09 TCGA−BH−A1ET−01A−11D−A135−09 TCGA−BH−A18M−01A−11D−A12B−09 TCGA−BH−A18J−01A−11D−A12B−09 TCGA−BH−A18I−01A−11D−A12B−09 TCGA−BH−A18H−01A−11D−A12B−09 TCGA−BH−A0W5−01A−11D−A10G−09 TCGA−BH−A0W3−01A−11D−A10G−09 TCGA−BH−A0HN−01A−11D−A099−09 TCGA−BH−A0HI−01A−11D−A099−09 TCGA−BH−A0H3−01A−11D−A12Q−09 TCGA−BH−A0GY−01A−11W−A071−09 TCGA−BH−A0EE−01A−11W−A050−09 TCGA−BH−A0EB−01A−11W−A050−09 TCGA−BH−A0EA−01A−11D−A10Y−09 TCGA−BH−A0DX−01A−11D−A10Y−09 TCGA−BH−A0DV−01A−21D−A12Q−09 TCGA−BH−A0DT−01A−21D−A12B−09 TCGA−BH−A0DP−01A−21W−A071−09 TCGA−BH−A0DO−01B−11D−A12B−09 TCGA−BH−A0DL−01A−11D−A10Y−09 TCGA−BH−A0DE−01A−11D−A10Y−09 TCGA−BH−A0DD−01A−31D−A12Q−09 TCGA−BH−A0BV−01A−11W−A019−09 TCGA−BH−A0BT−01A−11D−A12Q−09 TCGA−BH−A0BO−01A−23D−A12B−09 TCGA−BH−A0BM−01A−11W−A071−09 TCGA−BH−A0BF−01A−21D−A12Q−09 TCGA−BH−A0BD−01A−11W−A050−09 TCGA−BH−A0BC−01A−22D−A099−09 TCGA−BH−A0BA−01A−11W−A071−09 TCGA−BH−A0B0−01A−21D−A10Y−09 TCGA−B6−A1KI−01A−11D−A14K−09 TCGA−B6−A0X7−01A−11D−A10M−09 TCGA−B6−A0X5−01A−21D−A10G−09 TCGA−B6−A0WY−01A−11D−A10G−09 TCGA−B6−A0WW−01A−11D−A10G−09 TCGA−B6−A0RQ−01A−11D−A10Y−09 TCGA−B6−A0RO−01A−22D−A099−09 TCGA−B6−A0RN−01A−12D−A099−09 TCGA−B6−A0RH−01A−21D−A10Y−09 TCGA−B6−A0RG−01A−11W−A071−09 TCGA−B6−A0IP−01A−11D−A045−09 TCGA−B6−A0IK−01A−12W−A071−09 TCGA−B6−A0IE−01A−11W−A050−09 TCGA−B6−A0IC−01A−11W−A050−09 TCGA−B6−A0I5−01A−11W−A100−09 TCGA−AR−A255−01A−11D−A167−09 TCGA−AR−A24T−01A−11D−A167−09 TCGA−AR−A24O−01A−11D−A167−09 TCGA−AR−A1AW−01A−21D−A12Q−09 TCGA−AR−A1AV−01A−21D−A12Q−09 TCGA−AR−A1AL−01A−21D−A12Q−09 TCGA−AR−A0TZ−01A−12D−A099−09 TCGA−AR−A0TR−01A−11D−A099−09 TCGA−AQ−A1H2−01A−11D−A13L−09 TCGA−AQ−A0Y5−01A−11D−A14K−09 TCGA−AO−A12A−01A−21D−A10Y−09 TCGA−AO−A126−01A−11D−A10M−09 TCGA−AO−A125−01A−11D−A10M−09 TCGA−AO−A0JF−01A−11W−A071−09 TCGA−AO−A0JE−01A−11W−A071−09 TCGA−AO−A0JA−01A−11W−A071−09 TCGA−AO−A0J7−01A−11W−A050−09 TCGA−AO−A0J5−01A−11W−A050−09 TCGA−AO−A03N−01B−11D−A10M−09 TCGA−AO−A03L−01A−41W−A071−09 TCGA−AN−A0XS−01A−22D−A10G−09 TCGA−AN−A0XP−01A−11D−A117−09 TCGA−AN−A0XO−01A−11D−A10G−09 TCGA−AN−A0XL−01A−11D−A10M−09 TCGA−AN−A0FF−01A−11W−A050−09 TCGA−AN−A04C−01A−21W−A050−09 TCGA−AN−A049−01A−21W−A019−09 TCGA−AN−A03X−01A−21W−A019−09 TCGA−AC−A23E−01A−11D−A159−09 TCGA−A8−A0A9−01A−11W−A019−09 TCGA−A8−A0A1−01A−11W−A019−09 TCGA−A8−A09D−01A−11W−A019−09 TCGA−A8−A09C−01A−11W−A019−09 TCGA−A8−A096−01A−11W−A019−09 TCGA−A8−A08Z−01A−21W−A019−09 TCGA−A8−A08T−01A−21W−A019−09 TCGA−A8−A08R−01A−11W−A050−09 TCGA−A8−A08P−01A−11W−A019−09 TCGA−A8−A08O−01A−21W−A071−09 TCGA−A8−A08B−01A−11W−A019−09 TCGA−A8−A084−01A−21W−A019−09 TCGA−A8−A07Z−01A−11W−A019−09 TCGA−A8−A07G−01A−11W−A050−09 TCGA−A8−A07B−01A−11W−A019−09 TCGA−A8−A06U−01A−11W−A019−09 TCGA−A8−A06R−01A−11D−A015−09 TCGA−A8−A06P−01A−11W−A019−09 TCGA−A7−A26E−01A−11D−A167−09 TCGA−A7−A13G−01A−11D−A13L−09 TCGA−A7−A0DB−01A−11W−A019−09 TCGA−A7−A0D9−01A−31W−A071−09 TCGA−A7−A0CJ−01A−21W−A019−09 TCGA−A7−A0CH−01A−21W−A019−09 TCGA−A7−A0CG−01A−11W−A019−09 TCGA−A2−A25C−01A−11D−A167−09 TCGA−A2−A25A−01A−12D−A16D−09 TCGA−A2−A1G0−01A−11D−A13L−09 TCGA−A2−A1FZ−01A−51D−A17G−09 TCGA−A2−A0YT−01A−11D−A10G−09 TCGA−A2−A0YI−01A−31D−A10M−09 TCGA−A2−A0YH−01A−11D−A10G−09 TCGA−A2−A0YC−01A−11D−A117−09 TCGA−A2−A0T4−01A−31D−A099−09 TCGA−A2−A0SY−01A−31D−A099−09 TCGA−A2−A0EX−01A−21W−A050−09 TCGA−A2−A0EW−01A−21D−A10Y−09 TCGA−A2−A0EQ−01A−11W−A050−09 TCGA−A2−A0EO−01A−11W−A050−09 TCGA−A2−A0EN−01A−13D−A099−09 TCGA−A2−A0EM−01A−11W−A050−09 TCGA−A2−A0D3−01A−11D−A10Y−09 TCGA−A2−A0D1−01A−11W−A050−09 TCGA−A2−A0CW−01A−21D−A10Y−09 TCGA−A2−A0CP−01A−11W−A050−09 TCGA−A2−A04W−01A−31D−A10Y−09 TCGA−A2−A04V−01A−21W−A050−09 TCGA−A2−A04P−01A−31D−A128−09 TCGA−A1−A0SI−01A−11D−A142−09 SA223 SA218 SA215 SA074 SA056 CSB6 CSB30 CSB3 CSB27 CSB26 CSB24 CSB21 CSB17 CSB15 CSB13 CSB12 CGP_donor_1329917 CGP_donor_1310129 CGP_donor_1230732 CGP_donor_1230726 CGP_donor_1212376 CGP_donor_1212367 CGP_donor_1212365 CGP_donor_1199132 CGP_donor_1199130 CGP_donor_1195184 CGP_donor_1186988 CGP_donor_1184344 CGP_donor_1184343 CGP_donor_1163909 CGP_donor_1163904 CGP_donor_1163900 CGP_donor_1163898 BRC9 BRC8 BRC52 BRC51 BRC47 BRC40 BRC39 BRC37 BRC36 BRC33 BRC31 BRC28 BRC24 BRC15 BRC11 BRC10 BR−V−071 BR−V−064 BR−V−052 BR−V−034 BR−V−024 BR−V−021 BR−V−020 BR−V−015 BR−V−003 BR−M−184 BR−M−169 BR−M−166 BR−M−165 BR−M−158 BR−M−121 BR−M−120 BR−M−098 BR−M−083 BR−M−059 BR−M−055 BR−M−036 BR−M−030 BR−M−028 BR−M−026

TCGA−AO−A1KS−01A−11D−A13L−09 SA054 TCGA−C8−A12W−01A−11D−A10Y−09 TCGA−AO−A03T−01A−21W−A050−09 TCGA−A8−A06Y−01A−21W−A019−09 SA071 CGP_donor_1163909 BR−V−026 CGP_donor_1163918 TCGA−A2−A0T1−01A−21D−A099−09 TCGA−A2−A25B−01A−11D−A167−09 CGP_donor_1199104 TCGA−B6−A0WY−01A−11D−A10G−09 TCGA−A8−A08L−01A−11W−A019−09 TCGA−E2−A153−01A−12D−A12B−09 TCGA−A8−A0A1−01A−11W−A019−09 TCGA−A2−A0EY−01A−11W−A050−09 TCGA−E9−A1NC−01A−12W−A16L−09 TCGA−C8−A26Z−01A−11D−A16D−09 CGP_donor_1163906 TCGA−BH−A18Q−01A−12D−A12B−09 BR−V−067 CGP_donor_1310130 TCGA−E2−A1L8−01A−11D−A13L−09 SA106 CGP_donor_1230727 TCGA−A2−A25E−01A−11D−A167−09 CSB8 TCGA−AR−A24S−01A−11D−A167−09 TCGA−A8−A09Q−01A−11W−A019−09 CGP_donor_1310129 BR−M−166 TCGA−B6−A0IB−01A−11W−A050−09 TCGA−A1−A0SF−01A−11D−A142−09 TCGA−E9−A1NA−01A−11D−A142−09 BR−M−047 TCGA−E2−A1LH−01A−11D−A14G−09 CGP_donor_1234118 CGP_donor_1163902 TCGA−D8−A1XR−01A−11D−A14K−09 TCGA−BH−A0EE−01A−11W−A050−09 TCGA−AC−A23C−01A−12D−A167−09 TCGA−A7−A0DA−01A−31D−A10Y−09 TCGA−D8−A1J9−01A−11D−A13L−09 TCGA−C8−A275−01A−21D−A16D−09 TCGA−D8−A1JP−01A−11D−A13L−09 TCGA−AR−A0TS−01A−11D−A10Y−09 TCGA−A2−A0YJ−01A−11D−A10G−09 TCGA−E9−A1RF−01A−11D−A159−09 TCGA−A2−A0YM−01A−11D−A10G−09 BR−M−076 CGP_donor_1163903 BRC41 BR−V−044 TCGA−EW−A1OV−01A−11D−A142−09 TCGA−E2−A152−01A−11D−A12B−09 TCGA−BH−A0BV−01A−11W−A019−09 TCGA−E2−A1LG−01A−21D−A14K−09 CGP_donor_1234119 BR−M−098 TCGA−D8−A1JK−01A−11D−A13L−09 TCGA−A7−A26G−01A−21D−A167−09 TCGA−A2−A0YK−01A−22D−A117−09 CGP_donor_1184341 TCGA−D8−A1Y1−01A−21D−A14K−09 TCGA−C8−A134−01A−11D−A10Y−09 TCGA−A8−A07P−01A−11W−A019−09 TCGA−A2−A0EW−01A−21D−A10Y−09 TCGA−BH−A0C1−01B−11D−A12B−09 TCGA−A2−A0EO−01A−11W−A050−09 CGP_donor_1212378 BR−V−054 TCGA−E9−A1R4−01A−21D−A14G−09 TCGA−E2−A154−01A−11D−A10Y−09 TCGA−E2−A108−01A−13D−A10M−09 TCGA−B6−A0IQ−01A−11W−A050−09 TCGA−A8−A0A9−01A−11W−A019−09 TCGA−E2−A15O−01A−11D−A10Y−09 TCGA−E2−A10F−01A−11D−A10M−09 TCGA−BH−A18U−01A−21D−A12B−09 TCGA−BH−A0DD−01A−31D−A12Q−09 TCGA−BH−A0BC−01A−22D−A099−09 CSB9 CGP_donor_1163915 TCGA−EW−A1PB−01A−11D−A142−09 TCGA−E2−A1L7−01A−11D−A142−09 TCGA−C8−A132−01A−31D−A10Y−09 TCGA−A7−A0D9−01A−31W−A071−09 TCGA−A2−A0YG−01A−21D−A10G−09 CGP_donor_1230756 BR−V−037 TCGA−BH−A0DS−01A−11W−A071−09 TCGA−E2−A1L9−01A−11D−A13L−09 TCGA−C8−A12T−01A−11D−A10Y−09 TCGA−BH−A0WA−01A−11D−A10G−09 TCGA−B6−A0X1−01A−11D−A10G−09 TCGA−A7−A26H−01A−11D−A167−09 TCGA−A1−A0SO−01A−22D−A099−09 TCGA−A1−A0SH−01A−11D−A099−09 BR−V−036 BR−M−027 TCGA−A2−A0EQ−01A−11W−A050−09 BRC35 TCGA−E9−A1R0−01A−22D−A16D−09 TCGA−E2−A1B4−01A−11D−A12Q−09 TCGA−D8−A1X5−01A−11D−A14G−09 TCGA−B6−A0I9−01A−11W−A050−09 TCGA−A7−A0CH−01A−21W−A019−09 TCGA−A2−A0SX−01A−12D−A099−09 SA031 CGP_donor_1199101 BR−M−005 TCGA−E2−A159−01A−11D−A10Y−09 TCGA−AN−A0XU−01A−11D−A10G−09 CGP_donor_1234117 BR−V−064 TCGA−E2−A14V−01A−11D−A12B−09 TCGA−C8−A26X−01A−31D−A16D−09 TCGA−AN−A0FW−01A−11W−A050−09 TCGA−A8−A090−01A−11W−A019−09 TCGA−A2−A0CT−01A−31W−A071−09 CGP_donor_1234110 CGP_donor_1163916 BR−M−080 BRC39 CSB1 TCGA−E9−A243−01A−21D−A167−09 TCGA−E2−A1IN−01A−11D−A13L−09 TCGA−E2−A155−01A−11D−A12B−09 TCGA−C8−A1HJ−01A−11D−A13L−09 TCGA−A2−A25D−01A−12D−A16D−09 TCGA−A2−A04W−01A−31D−A10Y−09 SA227 SA220 SA218 SA210 CGP_donor_1199134 BRC47 BRC42 BRC16 BR−V−027 CGP_donor_1230733 TCGA−AR−A251−01A−12D−A167−09 TCGA−AR−A0U4−01A−11D−A117−09 CGP_donor_1199074 TCGA−D8−A27N−01A−11D−A16D−09 TCGA−D8−A1X8−01A−11D−A14K−09 TCGA−C8−A1HK−01A−21D−A13L−09 TCGA−C8−A12P−01A−11D−A10Y−09 TCGA−AR−A1AX−01A−11D−A12Q−09 TCGA−AR−A1AK−01A−21D−A12Q−09 TCGA−AO−A0JM−01A−21W−A071−09 TCGA−AO−A0J9−01A−11W−A050−09 TCGA−A8−A0A7−01A−11W−A019−09 TCGA−A8−A09R−01A−11W−A019−09 TCGA−A8−A09A−01A−11W−A019−09 TCGA−A8−A096−01A−11W−A019−09 TCGA−A8−A094−01A−11W−A019−09 TCGA−A8−A07R−01A−21W−A050−09 TCGA−A8−A06X−01A−21W−A019−09 TCGA−A7−A0DB−01A−11W−A019−09 TCGA−A2−A1FW−01A−11D−A13L−09 SA214 SA030 CGP_donor_1212372 CGP_donor_1163917 BR−V−013 BB9T BB22T CGP_donor_1234112 TCGA−AN−A0XW−01A−11D−A10G−09 CGP_donor_1212368 CGP_donor_1212361 TCGA−C8−A274−01A−11D−A16D−09 TCGA−BH−A0BZ−01A−31D−A12Q−09 TCGA−A8−A08R−01A−11W−A050−09 TCGA−A1−A0SI−01A−11D−A142−09 SA083 SA069 CGP_donor_1230730 CGP_donor_1212360 CGP_donor_1199128 BRC18 BRC13 BR−M−191 BR−M−037 TCGA−EW−A1IW−01A−11D−A13L−09 TCGA−E2−A1LL−01A−11D−A142−09 TCGA−E2−A1LB−01A−11D−A142−09 TCGA−E2−A1IL−01A−11D−A14G−09 TCGA−E2−A15T−01A−11D−A10Y−09 TCGA−D8−A27H−01A−11D−A16D−09 TCGA−D8−A1JD−01A−11D−A13L−09 TCGA−BH−A1FC−01A−11D−A13L−09 TCGA−BH−A18S−01A−11D−A12B−09 TCGA−BH−A18N−01A−11D−A12B−09 TCGA−BH−A0E0−01A−11W−A071−09 TCGA−BH−A0AW−01A−11W−A071−09 TCGA−AR−A24Q−01A−12D−A167−09 TCGA−AR−A24H−01A−11D−A167−09 TCGA−AR−A1AH−01A−11D−A12B−09 TCGA−AO−A1KO−01A−31D−A188−09 TCGA−AO−A12E−01A−11D−A10M−09 TCGA−AO−A124−01A−11D−A10M−09 TCGA−AN−A0XN−01A−21D−A10G−09 TCGA−AN−A0AT−01A−11D−A045−09 TCGA−A8−A095−01A−11W−A019−09 TCGA−A2−A0YH−01A−11D−A10G−09 SA237 SA056 CGP_donor_1212376 BRC5 BRC24 BRC14 BRC11 BR−V−002 BR−M−116

Wnt Signaling Pathway FDR = 1.4e−09%, FDR nod = 0.00094% Signaling By PDGF FDR = 0.0026%, FDR nod = 0.0058%

TCGA−B6−A0RT−01A−21D−A099−09 BR−M−079 BRC24 TCGA−A1−A0SQ−01A−21D−A142−09 TCGA−BH−A0HK−01A−11W−A071−09 BR−M−155 CGP_donor_1212369 TCGA−BH−A1FC−01A−11D−A13L−09 TCGA−AN−A0AS−01A−11W−A019−09 BRC29 TCGA−C8−A1HK−01A−21D−A13L−09 TCGA−AC−A23E−01A−11D−A159−09 TCGA−E2−A109−01A−11D−A10M−09 TCGA−B6−A0IQ−01A−11W−A050−09 BR−V−008 TCGA−D8−A147−01A−11D−A10Y−09 SA213 TCGA−AR−A1AT−01A−11D−A12Q−09 TCGA−BH−A0AW−01A−11W−A071−09 TCGA−EW−A1PB−01A−11D−A142−09 BR−M−110 TCGA−E9−A1R2−01A−11D−A14G−09 TCGA−E9−A1RE−01A−11D−A159−09 TCGA−EW−A1IW−01A−11D−A13L−09 TCGA−E2−A14Z−01A−11D−A10Y−09 TCGA−B6−A0IE−01A−11W−A050−09 BR−V−048 TCGA−E2−A155−01A−11D−A12B−09 BR−M−169 BR−V−050 TCGA−BH−A0HN−01A−11D−A099−09 TCGA−D8−A1X7−01A−11D−A14K−09 TCGA−E2−A105−01A−11D−A10M−09 TCGA−BH−A204−01A−11D−A159−09 TCGA−BH−A0H3−01A−11D−A12Q−09 BR−V−031 TCGA−A8−A09T−01A−11W−A019−09 TCGA−D8−A1JM−01A−11D−A13L−09 TCGA−D8−A27L−01A−11D−A16D−09 TCGA−D8−A1XY−01A−11D−A14K−09 CGP_donor_1184343 TCGA−A8−A09A−01A−11W−A019−09 CGP_donor_1195183 TCGA−BH−A1FN−01A−11D−A13L−09 TCGA−E2−A15R−01A−11D−A10Y−09 TCGA−E9−A1N5−01A−11D−A14G−09 TCGA−C8−A12L−01A−11D−A10Y−09 TCGA−A7−A0DB−01A−11W−A019−09 CGP_donor_1212366 TCGA−E9−A1NH−01A−11D−A14G−09 TCGA−E9−A1NA−01A−11D−A142−09 TCGA−C8−A12K−01A−21D−A10Y−09 TCGA−D8−A1X9−01A−12D−A159−09 CSB29 TCGA−A7−A13F−01A−11D−A12Q−09 CSB13 TCGA−E9−A1RC−01A−11D−A159−09 TCGA−AR−A24K−01A−11D−A167−09 TCGA−BH−A0HB−01A−11W−A071−09 CGP_donor_1199133 CGP_donor_1199100 BRC13 TCGA−BH−A1EU−01A−11D−A135−09 TCGA−BH−A0BO−01A−23D−A12B−09 TCGA−A2−A0YH−01A−11D−A10G−09 CSB3 TCGA−A2−A04U−01A−11D−A10Y−09 TCGA−D8−A1JT−01A−31D−A13L−09 TCGA−D8−A27I−01A−11D−A16D−09 TCGA−A8−A07G−01A−11W−A050−09 TCGA−C8−A12P−01A−11D−A10Y−09 BR−M−047 TCGA−E9−A1RD−01A−11D−A159−09 TCGA−E2−A158−01A−11D−A12B−09 TCGA−BH−A0B7−01A−12D−A10Y−09 TCGA−A8−A06U−01A−11W−A019−09 TCGA−C8−A132−01A−31D−A10Y−09 TCGA−A8−A0A2−01A−11W−A050−09 TCGA−D8−A1JC−01A−11D−A13L−09 BR−M−094 TCGA−AN−A04D−01A−21W−A050−09 TCGA−A7−A0CE−01A−11W−A019−09 TCGA−D8−A1JJ−01A−31D−A14K−09 TCGA−A7−A0D9−01A−31W−A071−09 TCGA−E2−A15C−01A−31D−A12B−09 TCGA−C8−A12Z−01A−11D−A10Y−09 TCGA−D8−A27R−01A−11D−A16D−09 TCGA−C8−A137−01A−11D−A10Y−09 BR−M−073 CGP_donor_1230727 TCGA−E9−A245−01A−22D−A16D−09 TCGA−B6−A0IK−01A−12W−A071−09 TCGA−E2−A14O−01A−31D−A10Y−09 TCGA−BH−A0BC−01A−22D−A099−09 TCGA−D8−A1JG−01B−11D−A13L−09 TCGA−A8−A08H−01A−21W−A019−09 SA054 TCGA−A8−A07O−01A−11W−A019−09 TCGA−D8−A1XB−01A−11D−A14G−09 TCGA−AN−A0XS−01A−22D−A10G−09 TCGA−A2−A0T1−01A−21D−A099−09 BR−M−158 TCGA−A8−A09I−01A−22W−A050−09 TCGA−A2−A0YF−01A−21D−A10G−09 CGP_donor_1310130 TCGA−B6−A0RO−01A−22D−A099−09 TCGA−D8−A1JP−01A−11D−A13L−09 CSB9 TCGA−E2−A159−01A−11D−A10Y−09 TCGA−BH−A1EW−01A−11D−A135−09 BRC51 TCGA−A2−A0SW−01A−11D−A099−09 TCGA−C8−A26Z−01A−11D−A16D−09 TCGA−AO−A0JC−01A−11W−A071−09 BB30T BB23T TCGA−D8−A1J9−01A−11D−A13L−09 TCGA−A1−A0SI−01A−11D−A142−09 TCGA−EW−A1P4−01A−21D−A142−09 TCGA−C8−A12O−01A−11D−A10Y−09 TCGA−E9−A1NE−01A−21D−A14K−09 TCGA−AO−A1KT−01A−11D−A13L−09 BR−V−027 BR−V−016 BR−V−013 BR−V−011 TCGA−AR−A0TT−01A−31D−A099−09 TCGA−E2−A14P−01A−31D−A12B−09 BRC42 TCGA−AN−A0XW−01A−11D−A10G−09 TCGA−AR−A24N−01A−11D−A167−09 TCGA−AN−A0XV−01A−11D−A10G−09 TCGA−E9−A1RH−01A−21D−A167−09 TCGA−E2−A1L7−01A−11D−A142−09 TCGA−C8−A12W−01A−11D−A10Y−09 TCGA−E2−A1IO−01A−11D−A142−09 TCGA−AR−A254−01A−21D−A167−09 BB7T TCGA−BH−A0AY−01A−21W−A019−09 SA098 CGP_donor_1163918 TCGA−AO−A125−01A−11D−A10M−09 TCGA−A1−A0SD−01A−11D−A10Y−09 SA093 SA089 BR−M−105 CGP_donor_1199135 TCGA−E2−A1B5−01A−21D−A12Q−09 TCGA−E2−A15O−01A−11D−A10Y−09 TCGA−AQ−A1H3−01A−31D−A13L−09 TCGA−AN−A0FD−01A−11W−A050−09 TCGA−E2−A1LA−01A−11D−A142−09 SA225 TCGA−AR−A0TU−01A−31D−A10G−09 TCGA−A7−A0DA−01A−31D−A10Y−09 TCGA−BH−A0BR−01A−21W−A12T−09 TCGA−E9−A24A−01A−11D−A167−09 TCGA−E9−A243−01A−21D−A167−09 TCGA−E2−A15K−01A−11D−A12Q−09 TCGA−B6−A0RE−01A−11W−A071−09 BR−M−045 TCGA−AO−A0JB−01A−11W−A071−09 TCGA−BH−A0HY−01A−11W−A071−09 CGP_donor_1199129 BR−V−028 TCGA−AO−A0JL−01A−11W−A071−09 TCGA−AO−A0JI−01A−21W−A100−09 TCGA−A2−A0CM−01A−31W−A050−09 TCGA−AN−A0AJ−01A−11W−A019−09 TCGA−E2−A14W−01A−11D−A12B−09 TCGA−BH−A0C7−01B−11D−A10Y−09 TCGA−BH−A18U−01A−21D−A12B−09 TCGA−E2−A107−01A−11D−A10M−09 TCGA−C8−A273−01A−11D−A16D−09 TCGA−BH−A1ET−01A−11D−A135−09 TCGA−D8−A1XW−01A−11D−A14K−09 TCGA−A8−A097−01A−11W−A050−09 TCGA−A8−A07Z−01A−11W−A019−09 CSB34 TCGA−A8−A094−01A−11W−A019−09 TCGA−B6−A0X1−01A−11D−A10G−09 TCGA−C8−A131−01A−11D−A10Y−09 TCGA−B6−A0IA−01A−11W−A050−09 TCGA−D8−A1JL−01A−11D−A13L−09 TCGA−BH−A0B5−01A−11D−A12Q−09 BRC50 BRC35 TCGA−A2−A04P−01A−31D−A128−09 SA065 TCGA−D8−A143−01A−11D−A10Y−09 TCGA−AR−A0TW−01A−11D−A099−09 TCGA−A8−A09M−01A−11W−A019−09 TCGA−AR−A1AU−01A−11D−A12Q−09 CSB15 BRC8 TCGA−E2−A14S−01A−11D−A12B−09 TCGA−BH−A0BM−01A−11W−A071−09 BR−V−036 BR−M−055 CGP_donor_1212373 TCGA−C8−A1HI−01A−11D−A135−09 TCGA−AR−A1AR−01A−31D−A135−09 BR−V−030 TCGA−AO−A1KR−01A−12D−A142−09 TCGA−E9−A1R0−01A−22D−A16D−09 TCGA−A8−A07P−01A−11W−A019−09 TCGA−A2−A0YM−01A−11D−A10G−09 SA229 SA031 TCGA−B6−A0IM−01A−11W−A050−09 TCGA−A2−A04R−01A−41D−A117−09 TCGA−BH−A0BZ−01A−31D−A12Q−09 TCGA−C8−A26W−01A−11D−A16D−09 SA212 TCGA−BH−A0DI−01A−21D−A12Q−09 TCGA−AN−A0XN−01A−21D−A10G−09 TCGA−A8−A093−01A−11W−A019−09 CGP_donor_1230756 CGP_donor_1199134 TCGA−E9−A247−01A−11D−A167−09 TCGA−AR−A0U3−01A−11D−A10G−09 TCGA−AO−A0J6−01A−11W−A050−09 TCGA−BH−A0BW−01A−11D−A10Y−09 TCGA−E9−A1R3−01A−31D−A14K−09 TCGA−A2−A0EQ−01A−11W−A050−09 SA220 BR−V−009 BR−V−019 TCGA−A2−A25B−01A−11D−A167−09 TCGA−BH−A18I−01A−11D−A12B−09 TCGA−E2−A10E−01A−21D−A10M−09 TCGA−AR−A1AI−01A−11D−A12Q−09 TCGA−A2−A0EV−01A−11W−A050−09 TCGA−A2−A04W−01A−31D−A10Y−09 BR−V−014 TCGA−AQ−A04H−01B−11D−A10M−09 BR−V−037 TCGA−A8−A083−01A−21W−A019−09 TCGA−D8−A1JF−01A−11D−A13L−09 TCGA−BH−A18K−01A−11D−A12B−09 TCGA−AO−A03P−01A−11W−A019−09 CGP_donor_1230725 BR−M−129 TCGA−C8−A135−01A−11D−A10Y−09 TCGA−B6−A0RU−01A−11D−A099−09 TCGA−BH−A1EX−01A−11D−A13L−09 TCGA−AO−A0J3−01A−11W−A050−09 CGP_donor_1212359 TCGA−A2−A0CT−01A−31W−A071−09 CGP_donor_1234110 SA101 CGP_donor_1329918 BR−M−041 TCGA−C8−A12U−01A−11D−A10Y−09 TCGA−AO−A03V−01A−11D−A10Y−09 TCGA−A8−A06X−01A−21W−A019−09 TCGA−D8−A142−01A−11D−A10Y−09 TCGA−BH−A18V−01A−11D−A12B−09 TCGA−BH−A1FL−01A−11D−A13L−09 TCGA−E2−A15G−01A−11D−A12B−09 TCGA−A8−A096−01A−11W−A019−09 TCGA−BH−A18R−01A−11D−A12B−09 TCGA−B6−A0RN−01A−12D−A099−09 TCGA−A2−A0CS−01A−11D−A10Y−09 TCGA−E2−A1B4−01A−11D−A12Q−09 CSB22 TCGA−B6−A0RH−01A−21D−A10Y−09 TCGA−B6−A0I2−01A−11W−A050−09 TCGA−AO−A124−01A−11D−A10M−09 BR−M−074 CGP_donor_1234117 TCGA−BH−A0DE−01A−11D−A10Y−09 TCGA−E9−A248−01A−11D−A167−09 TCGA−A8−A06T−01A−11W−A019−09 CSB17 CGP_donor_1163910 TCGA−E2−A152−01A−11D−A12B−09 TCGA−BH−A0BP−01A−11D−A10Y−09 CGP_donor_1329921 TCGA−E9−A226−01A−21D−A159−09 TCGA−D8−A1XV−01A−11D−A14K−09 BR−M−028 TCGA−AR−A1AH−01A−11D−A12B−09 TCGA−A7−A26H−01A−11D−A167−09 TCGA−D8−A1Y0−01A−11D−A14K−09 TCGA−AN−A0FT−01A−11W−A050−09 CSB28 BR−V−070 TCGA−AN−A04C−01A−21W−A050−09 TCGA−D8−A27T−01A−11D−A16D−09 TCGA−BH−A0AU−01A−11D−A12Q−09 TCGA−B6−A0WZ−01A−11D−A10G−09 TCGA−A8−A0AD−01A−11W−A071−09 CGP_donor_1163917 SA218 TCGA−E9−A22G−01A−11D−A159−09 TCGA−D8−A1JS−01A−11D−A13L−09 TCGA−B6−A0RP−01A−21D−A099−09 TCGA−AN−A0FJ−01A−11W−A019−09 CGP_donor_1187021 TCGA−B6−A0RL−01A−11D−A099−09 TCGA−C8−A27B−01A−11D−A167−09 CGP_donor_1212368 TCGA−E9−A1N3−01A−12D−A159−09 TCGA−D8−A1XM−01A−21D−A14K−09 CGP_donor_1230730 TCGA−D8−A13Y−01A−11D−A10Y−09 TCGA−A2−A0EU−01A−22W−A071−09 TCGA−BH−A0B1−01A−12W−A071−09 TCGA−AO−A12D−01A−11D−A10Y−09 TCGA−A2−A0D4−01A−11W−A019−09 BRC49 BR−M−095 TCGA−A8−A08F−01A−11W−A019−09 BR−V−023 TCGA−A2−A0EM−01A−11W−A050−09 BR−V−043 TCGA−AR−A0TY−01A−12W−A12T−09 TCGA−AO−A12G−01A−11D−A10M−09 BR−M−026 TCGA−E2−A1LH−01A−11D−A14G−09 TCGA−D8−A1XT−01A−11D−A14K−09 BRC32 TCGA−E2−A1LG−01A−21D−A14K−09 TCGA−E2−A1BC−01A−11D−A14G−09 SA018 BRC15 BR−V−067 TCGA−A8−A06Q−01A−11W−A050−09 TCGA−AR−A256−01A−11D−A167−09 TCGA−EW−A1P8−01A−11D−A142−09 TCGA−A2−A25D−01A−12D−A16D−09 TCGA−BH−A1EY−01A−11D−A13L−09 TCGA−AO−A0JA−01A−11W−A071−09 TCGA−E2−A10B−01A−11D−A10M−09 TCGA−BH−A0BT−01A−11D−A12Q−09 TCGA−E2−A15S−01A−11D−A10Y−09 TCGA−AO−A12E−01A−11D−A10M−09 TCGA−A1−A0SG−01A−11D−A142−09 CGP_donor_1329917 BRC5 CGP_donor_1199101 TCGA−A8−A09N−01A−11W−A019−09 TCGA−D8−A1XZ−01A−11D−A14K−09 CGP_donor_1212375 TCGA−E9−A1N9−01A−11D−A14G−09 TCGA−AO−A0J2−01A−11W−A050−09 TCGA−A8−A084−01A−21W−A019−09 SA071 TCGA−BH−A0HX−01A−21W−A071−09 TCGA−A7−A26J−01A−11D−A167−09 SA097 CGP_donor_1199104 TCGA−E9−A22B−01A−11D−A159−09 TCGA−AO−A12B−01A−11D−A10M−09 SA094 TCGA−E2−A15E−01A−11D−A12B−09 TCGA−BH−A18N−01A−11D−A12B−09 TCGA−A8−A06O−01A−11W−A019−09 TCGA−BH−A0B8−01A−21W−A071−09 SA051 TCGA−E9−A244−01A−11D−A167−09 TCGA−BH−A1FM−01A−11D−A13L−09 TCGA−AO−A0JM−01A−21W−A071−09 CSB19 TCGA−E2−A1B0−01A−11D−A12Q−09 TCGA−D8−A1JK−01A−11D−A13L−09 TCGA−A8−A08L−01A−11W−A019−09 BR−M−174 TCGA−A2−A1FX−01A−11D−A13L−09 BR−M−085 TCGA−A8−A08P−01A−11W−A019−09 BR−M−184 BR−M−027 TCGA−AN−A0FX−01A−11W−A050−09 TCGA−A8−A09B−01A−11W−A019−09 CGP_donor_1199106 TCGA−AR−A0U4−01A−11D−A117−09 TCGA−EW−A1P6−01A−11D−A142−09 TCGA−D8−A1Y2−01A−11D−A159−09 TCGA−D8−A140−01A−11D−A10Y−09 SA224 CGP_donor_1187029 TCGA−A8−A09E−01A−11W−A019−09 CGP_donor_1212372 TCGA−E2−A15J−01A−11D−A12Q−09 TCGA−D8−A1XL−01A−11D−A14K−09 TCGA−BH−A1FD−01A−11W−A14Q−09 TCGA−B6−A0IH−01A−11D−A10Y−09 CSB31 CGP_donor_1212371 BR−M−191 TCGA−AN−A0AT−01A−11D−A045−09 SA214 TCGA−BH−A0W7−01A−11D−A10Y−09 BR−M−193 TCGA−D8−A27H−01A−11D−A16D−09 TCGA−C8−A26V−01A−11D−A16D−09 TCGA−C8−A1HE−01A−11D−A188−09 TCGA−B6−A1KF−01A−11D−A13L−09 TCGA−A2−A1G1−01A−21D−A13L−09 TCGA−E2−A1IN−01A−11D−A13L−09 TCGA−AR−A251−01A−12D−A167−09 TCGA−A8−A08O−01A−21W−A071−09 TCGA−A2−A0T0−01A−22D−A099−09 BR−V−034 BR−V−002 TCGA−EW−A1P5−01A−11D−A142−09 TCGA−A2−A0YJ−01A−11D−A10G−09 CGP_donor_1199074 TCGA−BH−A1F8−01A−11D−A13L−09 TCGA−BH−A0DX−01A−11D−A10Y−09 TCGA−B6−A0X5−01A−21D−A10G−09 TCGA−AQ−A1H2−01A−11D−A13L−09 TCGA−AN−A0XP−01A−11D−A117−09 TCGA−D8−A1JB−01A−11D−A13L−09 TCGA−AR−A255−01A−11D−A167−09 TCGA−AN−A0FV−01A−11W−A019−09 TCGA−A2−A0D0−01A−11W−A019−09 CSB16 TCGA−E9−A1RF−01A−11D−A159−09 TCGA−B6−A0RS−01A−11D−A099−09 TCGA−AR−A1AK−01A−21D−A12Q−09 TCGA−AN−A0XR−01A−11D−A10G−09 TCGA−E2−A1LS−01A−12D−A159−09 TCGA−E2−A14V−01A−11D−A12B−09 TCGA−E2−A14R−01A−11D−A10Y−09 TCGA−B6−A0I9−01A−11W−A050−09 TCGA−A8−A09K−01A−11W−A019−09 TCGA−A2−A0CU−01A−12W−A050−09 BRC47 CGP_donor_1212361 SA106 CGP_donor_1212360 CGP_donor_1234112 CGP_donor_1199128 TCGA−E2−A14Y−01A−21D−A12B−09 TCGA−BH−A18T−01A−11D−A12B−09 TCGA−BH−A0W4−01A−11D−A10G−09 TCGA−A1−A0SO−01A−22D−A099−09 TCGA−EW−A1PH−01A−11D−A14K−09 TCGA−E2−A150−01A−11D−A12B−09 TCGA−B6−A0IC−01A−11W−A050−09 BR−M−122 TCGA−E9−A1NI−01A−11W−A16H−09 TCGA−AN−A0FL−01A−11W−A050−09 TCGA−AO−A03T−01A−21W−A050−09 TCGA−A7−A13D−01A−13D−A12Q−09 CGP_donor_1212364 TCGA−C8−A275−01A−21D−A16D−09 TCGA−AN−A0XU−01A−11D−A10G−09 TCGA−A8−A08T−01A−21W−A019−09 BR−V−039 TCGA−E2−A1II−01A−11D−A142−09 TCGA−D8−A1X6−01A−11D−A14K−09 TCGA−C8−A12N−01A−11D−A10Y−09 TCGA−C8−A12M−01A−11D−A135−09 TCGA−B6−A0X0−01A−21D−A10Y−09 TCGA−AR−A1AW−01A−21D−A12Q−09 TCGA−A8−A07R−01A−21W−A050−09 CGP_donor_1329919 TCGA−BH−A1EO−01A−11D−A135−09 TCGA−A8−A07J−01A−11W−A019−09 BR−M−116 TCGA−E2−A1IG−01A−11D−A142−09 TCGA−C8−A1HL−01A−11D−A135−09 TCGA−C8−A12T−01A−11D−A10Y−09 TCGA−BH−A0HW−01A−11W−A050−09 TCGA−A8−A07I−01A−11W−A019−09 TCGA−A8−A06N−01A−11W−A019−09 BRC18 BR−V−052 TCGA−EW−A1OX−01A−11D−A142−09 TCGA−D8−A1JI−01A−11D−A13L−09 TCGA−D8−A1JD−01A−11D−A13L−09 TCGA−BH−A0EE−01A−11W−A050−09 TCGA−BH−A0E7−01A−11W−A050−09 TCGA−B6−A0RG−01A−11W−A071−09 TCGA−A1−A0SP−01A−11D−A099−09 CSB8 CSB23 CGP_donor_1234116 CGP_donor_1186988 CGP_donor_1163911 BRC11 TCGA−A8−A08R−01A−11W−A050−09 TCGA−AR−A0TV−01A−21D−A099−09 TCGA−AN−A0AL−01A−11W−A019−09 CGP_donor_1199131 BRC44 TCGA−AR−A24Q−01A−12D−A167−09 TCGA−A8−A09Q−01A−11W−A019−09 BR−M−189 TCGA−EW−A1P0−01A−11D−A142−09 TCGA−EW−A1OV−01A−11D−A142−09 TCGA−C8−A134−01A−11D−A10Y−09 TCGA−BH−A1EV−01A−11D−A135−09 TCGA−BH−A0WA−01A−11D−A10G−09 TCGA−AR−A0U2−01A−11D−A10G−09 TCGA−A8−A08Z−01A−21W−A019−09 TCGA−A8−A07L−01A−11W−A019−09 TCGA−A8−A07C−01A−11D−A045−09 TCGA−A2−A0SV−01A−11D−A099−09 CGP_donor_1230782 TCGA−E9−A1N8−01A−11D−A142−09 TCGA−E2−A1B1−01A−21D−A12Q−09 TCGA−C8−A1HJ−01A−11D−A13L−09 TCGA−B6−A0I6−01A−11D−A128−09 TCGA−AO−A0JD−01A−11W−A071−09 TCGA−AO−A0J4−01A−11W−A050−09 TCGA−AN−A0FZ−01A−11W−A050−09 TCGA−A8−A07W−01A−11W−A019−09 TCGA−A7−A13G−01A−11D−A13L−09 TCGA−A1−A0SK−01A−12D−A099−09 BR−M−167 CSB1 CGP_donor_1230733 TCGA−D8−A1Y1−01A−21D−A14K−09 TCGA−A2−A0YK−01A−22D−A117−09 TCGA−GI−A2C8−01A−11D−A16D−09 TCGA−C8−A274−01A−11D−A16D−09 TCGA−A8−A09W−01A−11W−A019−09 TCGA−E2−A1IH−01A−11D−A188−09 TCGA−D8−A1JN−01A−11D−A13L−09 TCGA−BH−A0HP−01A−12D−A099−09 TCGA−AO−A0J9−01A−11W−A050−09 TCGA−A8−A0A7−01A−11W−A019−09 TCGA−A2−A25A−01A−12D−A16D−09 SA077 CSB14 BRC39 BR−V−022 TCGA−EW−A1J2−01A−21D−A13L−09 TCGA−E2−A1L8−01A−11D−A13L−09 TCGA−E2−A10F−01A−11D−A10M−09 TCGA−D8−A1XO−01A−11D−A14K−09 TCGA−D8−A1X8−01A−11D−A14K−09 TCGA−C8−A1HO−01A−11D−A13L−09 TCGA−BH−A209−01A−11D−A17G−09 TCGA−BH−A18F−01A−11D−A12B−09 TCGA−BH−A0BA−01A−11W−A071−09 TCGA−AR−A24X−01A−11D−A167−09 TCGA−AR−A24H−01A−11D−A167−09 TCGA−A8−A09X−01A−11W−A019−09 TCGA−A8−A091−01A−11W−A019−09 TCGA−A8−A07F−01A−11W−A019−09 TCGA−A2−A0SY−01A−31D−A099−09 SA210 CGP_donor_1230726 CGP_donor_1199132 BR−M−126 TCGA−EW−A1J3−01A−11D−A13L−09 TCGA−E2−A1IJ−01A−11D−A142−09 TCGA−BH−A28Q−01A−11D−A16D−09 TCGA−BH−A0E9−01B−11D−A10Y−09 TCGA−BH−A0C1−01B−11D−A12B−09 TCGA−B6−A0RQ−01A−11D−A10Y−09 TCGA−B6−A0IP−01A−11D−A045−09 TCGA−AR−A24T−01A−11D−A167−09 TCGA−AR−A1AL−01A−21D−A12Q−09 TCGA−AO−A1KS−01A−11D−A13L−09 TCGA−AO−A0JJ−01A−11W−A071−09 TCGA−AO−A0J8−01A−21D−A045−09 TCGA−AN−A03Y−01A−21W−A019−09 TCGA−A8−A0AB−01A−11W−A050−09 TCGA−A8−A0A9−01A−11W−A019−09 TCGA−A8−A0A4−01A−11W−A019−09 TCGA−A8−A09V−01A−11D−A045−09 TCGA−A2−A1G0−01A−11D−A13L−09 TCGA−A2−A1FV−01A−11D−A13L−09 TCGA−A2−A0YD−01A−11D−A10G−09 TCGA−A2−A0T6−01A−11D−A099−09 TCGA−A2−A0T4−01A−31D−A099−09 TCGA−A2−A0EX−01A−21W−A050−09 TCGA−A2−A0EW−01A−21D−A10Y−09 TCGA−A1−A0SE−01A−11D−A099−09 CSB30 CSB12 CGP_donor_1230735 CGP_donor_1212378 CGP_donor_1212367 CGP_donor_1212362 CGP_donor_1184337 BRC38

TCGA−BH−A0DX−01A−11D−A10Y−09 TCGA−A2−A0T6−01A−11D−A099−09 TCGA−A8−A09Q−01A−11W−A019−09 TCGA−E9−A244−01A−11D−A167−09 TCGA−AR−A1AI−01A−11D−A12Q−09 TCGA−B6−A0RN−01A−12D−A099−09 TCGA−A8−A08A−01A−11W−A019−09 BRC39 TCGA−C8−A1HG−01A−11D−A135−09 TCGA−AN−A0FL−01A−11W−A050−09 BR−V−033 TCGA−E2−A1LH−01A−11D−A14G−09 TCGA−A8−A06X−01A−21W−A019−09 TCGA−A2−A04R−01A−41D−A117−09 TCGA−E2−A1B5−01A−21D−A12Q−09 TCGA−BH−A201−01A−11D−A14K−09 TCGA−B6−A0RH−01A−21D−A10Y−09 TCGA−EW−A1PE−01A−11D−A142−09 TCGA−A2−A0CM−01A−31W−A050−09 CGP_donor_1163917 BR−V−037 TCGA−E2−A152−01A−11D−A12B−09 TCGA−A8−A09K−01A−11W−A019−09 TCGA−A8−A07B−01A−11W−A019−09 BR−M−110 TCGA−EW−A1IW−01A−11D−A13L−09 TCGA−BH−A1F5−01A−12D−A13L−09 TCGA−B6−A0IE−01A−11W−A050−09 CSB10 TCGA−BH−A18Q−01A−12D−A12B−09 TCGA−AR−A0TP−01A−11D−A099−09 TCGA−AN−A0XT−01A−11D−A10G−09 BR−M−041 TCGA−BH−A0BP−01A−11D−A10Y−09 TCGA−B6−A0IO−01A−11W−A050−09 TCGA−AO−A12G−01A−11D−A10M−09 TCGA−AN−A0XW−01A−11D−A10G−09 CGP_donor_1187036 TCGA−BH−A0C0−01A−21W−A071−09 TCGA−AR−A1AP−01A−11D−A12Q−09 TCGA−AO−A0JB−01A−11W−A071−09 TCGA−AN−A03Y−01A−21W−A019−09 SA031 TCGA−A7−A26H−01A−11D−A167−09 TCGA−BH−A203−01A−12D−A167−09 TCGA−AN−A0FY−01A−11W−A050−09 TCGA−A2−A0D2−01A−21W−A050−09 SA106 BRC5 TCGA−E9−A1NI−01A−11W−A16H−09 TCGA−D8−A1JJ−01A−31D−A14K−09 TCGA−AR−A24Z−01A−11D−A167−09 TCGA−A8−A08H−01A−21W−A019−09 BRC41 BR−V−045 TCGA−AR−A1AV−01A−21D−A12Q−09 TCGA−AO−A12D−01A−11D−A10Y−09 CGP_donor_1230732 CGP_donor_1187032 CGP_donor_1163915 BRC50 BRC31 TCGA−EW−A1P8−01A−11D−A142−09 TCGA−E2−A1LG−01A−21D−A14K−09 TCGA−B6−A0RT−01A−21D−A099−09 TCGA−AN−A04D−01A−21W−A050−09 TCGA−A8−A09T−01A−11W−A019−09 CGP_donor_1234112 BRC7 BR−V−009 TCGA−E9−A1QZ−01A−21D−A167−09 TCGA−E2−A1IG−01A−11D−A142−09 TCGA−C8−A12M−01A−11D−A135−09 TCGA−BH−A0DK−01A−21W−A071−09 TCGA−AN−A0XN−01A−21D−A10G−09 TCGA−A2−A0EY−01A−11W−A050−09 SA235 BR−M−191 BR−M−106 TCGA−E9−A1N3−01A−12D−A159−09 TCGA−E2−A1AZ−01A−11D−A12Q−09 TCGA−D8−A146−01A−31D−A10Y−09 TCGA−BH−A1EY−01A−11D−A13L−09 TCGA−BH−A0C7−01B−11D−A10Y−09 TCGA−B6−A0I6−01A−11D−A128−09 TCGA−AR−A24Q−01A−12D−A167−09 TCGA−AR−A1AO−01A−11D−A12Q−09 TCGA−AN−A0XR−01A−11D−A10G−09 TCGA−A2−A1G4−01A−11D−A13L−09 TCGA−A2−A0CQ−01A−21W−A050−09 TCGA−A2−A0T0−01A−22D−A099−09 BR−V−027 TCGA−D8−A27E−01A−11D−A16D−09 TCGA−C8−A12W−01A−11D−A10Y−09 TCGA−BH−A1EO−01A−11D−A135−09 TCGA−AR−A1AR−01A−31D−A135−09 TCGA−AO−A1KS−01A−11D−A13L−09 TCGA−AC−A23C−01A−12D−A167−09 TCGA−A2−A25B−01A−11D−A167−09 TCGA−A2−A0YJ−01A−11D−A10G−09 TCGA−A2−A04N−01A−11D−A10Y−09 CSB1 CGP_donor_1230733 CGP_donor_1212363 CGP_donor_1163910 BR−M−193 BRC3 BR−V−043 TCGA−EW−A1PD−01A−11D−A142−09 TCGA−D8−A1JD−01A−11D−A13L−09 TCGA−AR−A1AS−01A−11D−A12Q−09 TCGA−AN−A0FV−01A−11W−A019−09 TCGA−AN−A0AJ−01A−11W−A019−09 TCGA−A8−A07R−01A−21W−A050−09 TCGA−A2−A25D−01A−12D−A16D−09 TCGA−A2−A0YM−01A−11D−A10G−09 TCGA−A2−A0T3−01A−21D−A10Y−09 SA228 SA210 SA071 SA069 CSB7 CGP_donor_1212368 BR−M−085

Constitutive Signaling By Aberrant PI3K In Cancer FDR = 7.3e−12%, FDR nod = 2.8%

known HCG mut

wt

TCGA−AR−A24H−01A−11D−A167−09 TCGA−A8−A08F−01A−11W−A019−09 BR−V−067 TCGA−E9−A1RB−01A−11D−A17G−09 TCGA−A8−A09A−01A−11W−A019−09 CGP_donor_1212364 TCGA−AN−A0FN−01A−11W−A050−09 TCGA−BH−A18V−01A−11D−A12B−09 CGP_donor_1230756 TCGA−AR−A0TY−01A−12W−A12T−09 TCGA−AN−A0FW−01A−11W−A050−09 TCGA−E2−A158−01A−11D−A12B−09 TCGA−BH−A1FM−01A−11D−A13L−09 TCGA−A8−A0AD−01A−11W−A071−09 TCGA−E9−A243−01A−21D−A167−09 TCGA−D8−A27F−01A−11D−A16D−09 TCGA−E2−A1B5−01A−21D−A12Q−09 TCGA−BH−A201−01A−11D−A14K−09 TCGA−E9−A244−01A−11D−A167−09 TCGA−AR−A1AI−01A−11D−A12Q−09 TCGA−C8−A12O−01A−11D−A10Y−09 TCGA−A1−A0SF−01A−11D−A142−09 TCGA−AO−A0J6−01A−11W−A050−09 CGP_donor_1329919 BR−M−191 BB22T TCGA−D8−A1XT−01A−11D−A14K−09 TCGA−A8−A085−01A−11W−A019−09 TCGA−BH−A0DI−01A−21D−A12Q−09 BR−M−155 TCGA−EW−A1J3−01A−11D−A13L−09 TCGA−A7−A13F−01A−11D−A12Q−09 TCGA−A2−A0D0−01A−11W−A019−09 TCGA−C8−A1HN−01A−11D−A135−09 TCGA−A8−A06X−01A−21W−A019−09 CSB9 TCGA−AN−A04A−01A−21W−A050−09 TCGA−E9−A1NC−01A−12W−A16L−09 TCGA−AN−A0AM−01A−11W−A050−09 CGP_donor_1199074 BR−V−037 TCGA−D8−A27I−01A−11D−A16D−09 TCGA−AR−A250−01A−31D−A167−09 TCGA−A2−A04Y−01A−21W−A050−09 TCGA−AN−A0XU−01A−11D−A10G−09 TCGA−A2−A0CX−01A−21W−A019−09 SA072 BR−V−002 TCGA−GI−A2C8−01A−11D−A16D−09 TCGA−E9−A1NA−01A−11D−A142−09 TCGA−AN−A0FL−01A−11W−A050−09 TCGA−A8−A09X−01A−11W−A019−09 TCGA−AO−A12D−01A−11D−A10Y−09 TCGA−A2−A0T0−01A−22D−A099−09 CGP_donor_1187032 CGP_donor_1163915 BR−V−043 TCGA−D8−A1JC−01A−11D−A13L−09 CGP_donor_1199101 TCGA−BH−A0B4−01A−11W−A019−09 TCGA−A1−A0SO−01A−22D−A099−09 SA231 TCGA−E2−A14Q−01A−11D−A12B−09 TCGA−BH−A1FD−01A−11W−A14Q−09 TCGA−AR−A0TQ−01A−11D−A099−09 TCGA−AO−A0JG−01A−31D−A099−09 SA208 CGP_donor_1199128 TCGA−E2−A150−01A−11D−A12B−09 TCGA−AN−A0AT−01A−11D−A045−09 TCGA−A8−A08A−01A−11W−A019−09 TCGA−A8−A07C−01A−11D−A045−09 CGP_donor_1199106 CGP_donor_1199103 BR−M−079 CGP_donor_1230725 TCGA−C8−A26Z−01A−11D−A16D−09 TCGA−AN−A0FX−01A−11W−A050−09 TCGA−AN−A0FV−01A−11W−A019−09 SA030 CGP_donor_1234116 CGP_donor_1163913 TCGA−C8−A1HG−01A−11D−A135−09 TCGA−AR−A0TV−01A−21D−A099−09 TCGA−AO−A12G−01A−11D−A10M−09 TCGA−A8−A094−01A−11W−A019−09 SA213 BR−V−014 BR−M−110 BR−M−027 TCGA−C8−A135−01A−11D−A10Y−09 TCGA−A8−A06Z−01A−11W−A019−09 BR−V−060 BR−M−095 TCGA−EW−A1PD−01A−11D−A142−09 TCGA−BH−A0C1−01B−11D−A12B−09 TCGA−A8−A0AB−01A−11W−A050−09 TCGA−A2−A0T6−01A−11D−A099−09 SA096 SA065 BRC14 BR−M−094 TCGA−E2−A15K−01A−11D−A12Q−09 TCGA−C8−A12T−01A−11D−A10Y−09 TCGA−AN−A0FS−01A−11W−A050−09 TCGA−A2−A04P−01A−31D−A128−09 SA218 CGP_donor_1230733 BRC50 BRC39 TCGA−E9−A1R5−01A−11D−A14K−09 TCGA−E9−A1NI−01A−11W−A16H−09 TCGA−D8−A1XM−01A−21D−A14K−09 TCGA−D8−A1XL−01A−11D−A14K−09 TCGA−D8−A1JN−01A−11D−A13L−09 TCGA−D8−A1JF−01A−11D−A13L−09 TCGA−D8−A1JE−01A−11D−A13L−09 TCGA−C8−A274−01A−11D−A16D−09 TCGA−C8−A26X−01A−31D−A16D−09 TCGA−C8−A12L−01A−11D−A10Y−09 TCGA−BH−A1FE−01A−11D−A13L−09 TCGA−BH−A1F8−01A−11D−A13L−09 TCGA−BH−A18I−01A−11D−A12B−09 TCGA−BH−A0W7−01A−11D−A10Y−09 TCGA−BH−A0H9−01A−11W−A071−09 TCGA−BH−A0EE−01A−11W−A050−09 TCGA−BH−A0BO−01A−23D−A12B−09 TCGA−BH−A0BC−01A−22D−A099−09 TCGA−B6−A0RH−01A−21D−A10Y−09 TCGA−B6−A0RG−01A−11W−A071−09 TCGA−B6−A0IK−01A−12W−A071−09 TCGA−AR−A24M−01A−11D−A167−09 TCGA−AR−A24K−01A−11D−A167−09 TCGA−AR−A1AV−01A−21D−A12Q−09 TCGA−AO−A12A−01A−21D−A10Y−09 TCGA−AO−A03N−01B−11D−A10M−09 TCGA−A8−A0A7−01A−11W−A019−09 TCGA−A8−A095−01A−11W−A019−09 TCGA−A8−A08Z−01A−21W−A019−09 TCGA−A8−A08O−01A−21W−A071−09 TCGA−A8−A084−01A−21W−A019−09 TCGA−A8−A07G−01A−11W−A050−09 TCGA−A8−A06Q−01A−11W−A050−09 TCGA−A7−A0CG−01A−11W−A019−09 TCGA−A2−A0YT−01A−11D−A10G−09 TCGA−A2−A0SY−01A−31D−A099−09 TCGA−A2−A0D3−01A−11D−A10Y−09 SA214 SA074 SA056 CGP_donor_1230732 CGP_donor_1212378 CGP_donor_1212367 BRC7 BRC33 BRC31 BR−V−034 BR−V−027 TCGA−EW−A1PE−01A−11D−A142−09 TCGA−EW−A1P0−01A−11D−A142−09 TCGA−EW−A1OV−01A−11D−A142−09 TCGA−EW−A1J2−01A−21D−A13L−09 TCGA−EW−A1J1−01A−11D−A188−09 TCGA−EW−A1IX−01A−12D−A142−09 TCGA−EW−A1IW−01A−11D−A13L−09 TCGA−E9−A295−01A−11D−A16D−09 TCGA−E9−A249−01A−11D−A167−09 TCGA−E9−A229−01A−31D−A17G−09 TCGA−E9−A227−01A−11D−A159−09 TCGA−E9−A226−01A−21D−A159−09 TCGA−E9−A1RI−01A−11D−A167−09 TCGA−E9−A1RE−01A−11D−A159−09 TCGA−E9−A1RD−01A−11D−A159−09 TCGA−E9−A1RC−01A−11D−A159−09 TCGA−E9−A1RA−01A−11D−A14G−09 TCGA−E9−A1R4−01A−21D−A14G−09 TCGA−E9−A1R3−01A−31D−A14K−09 TCGA−E9−A1R0−01A−22D−A16D−09 TCGA−E9−A1NH−01A−11D−A14G−09 TCGA−E9−A1NG−01A−21D−A14K−09 TCGA−E9−A1N5−01A−11D−A14G−09 TCGA−E2−A1L8−01A−11D−A13L−09 TCGA−E2−A1L6−01A−11D−A13L−09 TCGA−E2−A1IO−01A−11D−A142−09 TCGA−E2−A1IN−01A−11D−A13L−09 TCGA−E2−A1IL−01A−11D−A14G−09 TCGA−E2−A1IF−01A−11D−A142−09 TCGA−E2−A1BD−01A−11D−A12Q−09 TCGA−E2−A1BC−01A−11D−A14G−09 TCGA−E2−A1B4−01A−11D−A12Q−09 TCGA−E2−A15P−01A−11D−A10Y−09 TCGA−E2−A15L−01A−11D−A12B−09 TCGA−E2−A15G−01A−11D−A12B−09 TCGA−E2−A15E−01A−11D−A12B−09 TCGA−E2−A15C−01A−31D−A12B−09 TCGA−E2−A156−01A−11D−A12B−09 TCGA−E2−A154−01A−11D−A10Y−09 TCGA−E2−A153−01A−12D−A12B−09 TCGA−E2−A14Y−01A−21D−A12B−09 TCGA−E2−A14V−01A−11D−A12B−09 TCGA−E2−A10F−01A−11D−A10M−09 TCGA−E2−A10B−01A−11D−A10M−09 TCGA−E2−A105−01A−11D−A10M−09 TCGA−D8−A27T−01A−11D−A16D−09 TCGA−D8−A27P−01A−11D−A16D−09 TCGA−D8−A27L−01A−11D−A16D−09 TCGA−D8−A1Y2−01A−11D−A159−09 TCGA−D8−A1Y1−01A−21D−A14K−09 TCGA−D8−A1XY−01A−11D−A14K−09 TCGA−D8−A1XS−01A−11D−A14K−09 TCGA−D8−A1XO−01A−11D−A14K−09 TCGA−D8−A1JU−01A−11D−A13L−09 TCGA−D8−A1JS−01A−11D−A13L−09 TCGA−D8−A1JP−01A−11D−A13L−09 TCGA−D8−A1JK−01A−11D−A13L−09 TCGA−D8−A1JJ−01A−31D−A14K−09 TCGA−D8−A1JH−01A−11D−A188−09 TCGA−D8−A1JD−01A−11D−A13L−09 TCGA−D8−A146−01A−31D−A10Y−09 TCGA−D8−A143−01A−11D−A10Y−09 TCGA−C8−A278−01A−11D−A167−09 TCGA−C8−A26W−01A−11D−A16D−09 TCGA−C8−A1HF−01A−11D−A135−09 TCGA−C8−A1HE−01A−11D−A188−09 TCGA−C8−A133−01A−32D−A12B−09 TCGA−C8−A131−01A−11D−A10Y−09 TCGA−C8−A130−01A−31D−A10Y−09 TCGA−C8−A12Y−01A−11D−A12B−09 TCGA−C8−A12U−01A−11D−A10Y−09 TCGA−C8−A12N−01A−11D−A10Y−09 TCGA−BH−A208−01A−11D−A159−09 TCGA−BH−A203−01A−12D−A167−09 TCGA−BH−A202−01A−11D−A14K−09 TCGA−BH−A1EY−01A−11D−A13L−09 TCGA−BH−A1EU−01A−11D−A135−09 TCGA−BH−A1ET−01A−11D−A135−09 TCGA−BH−A18M−01A−11D−A12B−09 TCGA−BH−A18J−01A−11D−A12B−09 TCGA−BH−A18H−01A−11D−A12B−09 TCGA−BH−A18F−01A−11D−A12B−09 TCGA−BH−A0W5−01A−11D−A10G−09 TCGA−BH−A0W3−01A−11D−A10G−09 TCGA−BH−A0HN−01A−11D−A099−09 TCGA−BH−A0HI−01A−11D−A099−09 TCGA−BH−A0H3−01A−11D−A12Q−09 TCGA−BH−A0GY−01A−11W−A071−09 TCGA−BH−A0EB−01A−11W−A050−09 TCGA−BH−A0EA−01A−11D−A10Y−09 TCGA−BH−A0DX−01A−11D−A10Y−09 TCGA−BH−A0DV−01A−21D−A12Q−09 TCGA−BH−A0DT−01A−21D−A12B−09 TCGA−BH−A0DP−01A−21W−A071−09 TCGA−BH−A0DO−01B−11D−A12B−09 TCGA−BH−A0DL−01A−11D−A10Y−09 TCGA−BH−A0DK−01A−21W−A071−09 TCGA−BH−A0DE−01A−11D−A10Y−09 TCGA−BH−A0DD−01A−31D−A12Q−09 TCGA−BH−A0BV−01A−11W−A019−09 TCGA−BH−A0BT−01A−11D−A12Q−09 TCGA−BH−A0BM−01A−11W−A071−09 TCGA−BH−A0BF−01A−21D−A12Q−09 TCGA−BH−A0BD−01A−11W−A050−09 TCGA−BH−A0BA−01A−11W−A071−09 TCGA−BH−A0B0−01A−21D−A10Y−09 TCGA−B6−A1KI−01A−11D−A14K−09 TCGA−B6−A0X7−01A−11D−A10M−09 TCGA−B6−A0X5−01A−21D−A10G−09 TCGA−B6−A0WY−01A−11D−A10G−09 TCGA−B6−A0WW−01A−11D−A10G−09 TCGA−B6−A0RQ−01A−11D−A10Y−09 TCGA−B6−A0RP−01A−21D−A099−09 TCGA−B6−A0RO−01A−22D−A099−09 TCGA−B6−A0RN−01A−12D−A099−09 TCGA−B6−A0IP−01A−11D−A045−09 TCGA−B6−A0IE−01A−11W−A050−09 TCGA−B6−A0IC−01A−11W−A050−09 TCGA−B6−A0I5−01A−11W−A100−09 TCGA−AR−A255−01A−11D−A167−09 TCGA−AR−A24T−01A−11D−A167−09 TCGA−AR−A24S−01A−11D−A167−09 TCGA−AR−A24O−01A−11D−A167−09 TCGA−AR−A1AW−01A−21D−A12Q−09 TCGA−AR−A1AS−01A−11D−A12Q−09 TCGA−AR−A1AL−01A−21D−A12Q−09 TCGA−AR−A0TZ−01A−12D−A099−09 TCGA−AR−A0TR−01A−11D−A099−09 TCGA−AQ−A1H2−01A−11D−A13L−09 TCGA−AQ−A0Y5−01A−11D−A14K−09 TCGA−AO−A1KR−01A−12D−A142−09 TCGA−AO−A126−01A−11D−A10M−09 TCGA−AO−A125−01A−11D−A10M−09 TCGA−AO−A0JF−01A−11W−A071−09 TCGA−AO−A0JE−01A−11W−A071−09 TCGA−AO−A0JA−01A−11W−A071−09 TCGA−AO−A0J7−01A−11W−A050−09 TCGA−AO−A0J5−01A−11W−A050−09 TCGA−AO−A03L−01A−41W−A071−09 TCGA−AN−A0XS−01A−22D−A10G−09 TCGA−AN−A0XP−01A−11D−A117−09 TCGA−AN−A0XO−01A−11D−A10G−09 TCGA−AN−A0XL−01A−11D−A10M−09 TCGA−AN−A0FF−01A−11W−A050−09 TCGA−AN−A0AJ−01A−11W−A019−09 TCGA−AN−A04C−01A−21W−A050−09 TCGA−AN−A049−01A−21W−A019−09 TCGA−AN−A03Y−01A−21W−A019−09 TCGA−AN−A03X−01A−21W−A019−09 TCGA−AC−A23E−01A−11D−A159−09 TCGA−AC−A23C−01A−12D−A167−09 TCGA−A8−A0A9−01A−11W−A019−09 TCGA−A8−A0A1−01A−11W−A019−09 TCGA−A8−A09D−01A−11W−A019−09 TCGA−A8−A09C−01A−11W−A019−09 TCGA−A8−A096−01A−11W−A019−09 TCGA−A8−A093−01A−11W−A019−09 TCGA−A8−A092−01A−11W−A019−09 TCGA−A8−A08T−01A−21W−A019−09 TCGA−A8−A08R−01A−11W−A050−09 TCGA−A8−A08P−01A−11W−A019−09 TCGA−A8−A08L−01A−11W−A019−09 TCGA−A8−A08B−01A−11W−A019−09 TCGA−A8−A081−01A−11W−A019−09 TCGA−A8−A07Z−01A−11W−A019−09 TCGA−A8−A07E−01A−11W−A050−09 TCGA−A8−A07B−01A−11W−A019−09 TCGA−A8−A075−01A−11D−A099−09 TCGA−A8−A06U−01A−11W−A019−09 TCGA−A8−A06R−01A−11D−A015−09 TCGA−A8−A06P−01A−11W−A019−09 TCGA−A7−A26H−01A−11D−A167−09 TCGA−A7−A26E−01A−11D−A167−09 TCGA−A7−A13G−01A−11D−A13L−09 TCGA−A7−A0DB−01A−11W−A019−09 TCGA−A7−A0D9−01A−31W−A071−09 TCGA−A7−A0CJ−01A−21W−A019−09 TCGA−A7−A0CH−01A−21W−A019−09 TCGA−A2−A25C−01A−11D−A167−09 TCGA−A2−A25A−01A−12D−A16D−09 TCGA−A2−A1G0−01A−11D−A13L−09 TCGA−A2−A1FZ−01A−51D−A17G−09 TCGA−A2−A0YL−01A−21D−A10G−09 TCGA−A2−A0YK−01A−22D−A117−09 TCGA−A2−A0YI−01A−31D−A10M−09 TCGA−A2−A0YH−01A−11D−A10G−09 TCGA−A2−A0YC−01A−11D−A117−09 TCGA−A2−A0T7−01A−21D−A099−09 TCGA−A2−A0T4−01A−31D−A099−09 TCGA−A2−A0EY−01A−11W−A050−09 TCGA−A2−A0EX−01A−21W−A050−09 TCGA−A2−A0EW−01A−21D−A10Y−09 TCGA−A2−A0EV−01A−11W−A050−09 TCGA−A2−A0EQ−01A−11W−A050−09 TCGA−A2−A0EO−01A−11W−A050−09 TCGA−A2−A0EN−01A−13D−A099−09 TCGA−A2−A0EM−01A−11W−A050−09 TCGA−A2−A0D1−01A−11W−A050−09 TCGA−A2−A0CW−01A−21D−A10Y−09 TCGA−A2−A0CS−01A−11D−A10Y−09 TCGA−A2−A0CP−01A−11W−A050−09 TCGA−A2−A04W−01A−31D−A10Y−09 TCGA−A2−A04V−01A−21W−A050−09 TCGA−A2−A04N−01A−11D−A10Y−09 TCGA−A1−A0SI−01A−11D−A142−09 SA223 SA215 CSB6 CSB30 CSB3 CSB27 CSB26 CSB24 CSB21 CSB17 CSB15 CSB13 CSB12 CSB1 CGP_donor_1329917 CGP_donor_1310130 CGP_donor_1310129 CGP_donor_1234117 CGP_donor_1234112 CGP_donor_1230726 CGP_donor_1212376 CGP_donor_1212369 CGP_donor_1212368 CGP_donor_1212366 CGP_donor_1212365 CGP_donor_1212363 CGP_donor_1212361 CGP_donor_1212360 CGP_donor_1199132 CGP_donor_1199130 CGP_donor_1195184 CGP_donor_1187021 CGP_donor_1186988 CGP_donor_1184344 CGP_donor_1184343 CGP_donor_1163909 CGP_donor_1163904 CGP_donor_1163903 CGP_donor_1163900 CGP_donor_1163898 BRC9 BRC8 BRC52 BRC51 BRC5 BRC47 BRC40 BRC4 BRC37 BRC36 BRC3 BRC28 BRC24 BRC20 BRC18 BRC15 BRC13 BRC11 BRC10 BR−V−071 BR−V−064 BR−V−052 BR−V−024 BR−V−021 BR−V−020 BR−V−015 BR−V−003 BR−M−184 BR−M−169 BR−M−166 BR−M−165 BR−M−158 BR−M−150 BR−M−121 BR−M−120 BR−M−116 BR−M−098 BR−M−083 BR−M−059 BR−M−055 BR−M−050 BR−M−036 BR−M−030 BR−M−028 BR−M−026


Integrin Signalling Pathway FDR = 7e−12%, FDR nod = 0.95% GRB2:SOS Provides Linkage To MAPK Signaling For Integrins FDR = 1.9%, FDR nod = 1.3%

unknown CG mut TLN1

VWF

FGA

SOS1

known HCG mut

FN1

wt

ITGB3

PTK2

APBB1IP

FGG

ITGA2B

GRB2

RAP1B

FGB

wt wt COL9A1

unknown CG mut

COL6A6

COL6A5

COL4A2

PDGFRA COL4A4

COL4A1 PLG

COL6A2

COL9A3 THBS3

THBS4

PDGFRB PLAT

SPP1

THBS1

PDGFB

COL4A3 FURIN

COL6A1

COL9A2 THBS2

known HCG mut

wt

TP53 ATM ATR HERC2 BRCA1 MDC1 UBC BRIP1 HIST1H2BC HIST2H2BE TOPBP1 BLM HIST1H2BD RFC4 TP53BP1 BRE CDK2 CHEK2 CLSPN HIST1H2BE HIST1H4L PIAS4 RAD17 RAD50 RFC5 RNF168 WHSC1 BARD1 BRCC3 CCNA2 DNA2 EXO1 H2AFX HIST1H2BA HIST1H2BG HIST1H2BH HIST1H2BJ HIST1H2BM HIST1H4C HIST1H4D HIST1H4E HIST1H4J MRE11A NBN PPP4C RAD1 RAD9A RBBP8 RFC2 RHNO1 RMI1 RPA1 RPA3 UBA52 BABAM1 HIST1H2BB HIST1H2BF HIST1H2BK HIST3H3 HUS1 PPP4R2 RPA2 SUMO1 SUMO2 TIMELESS TIPIN TOP3A UBE2V2 UIMC1 WRN

known HCG mut known HCG mut COL4A5

unknown CG mut PIK3CA ERBB2 EGFR ERBB3 ERBB4 PIK3R1 CD19 PDGFRA FGFR2 KL KLB PIK3CB FGF23 VAV1 FGF3 FGFR4 GAB1 GRB2 KITLG PDGFB PDGFRB PIK3CD BTC CD28 CD86 EGF FGF10 FGF6 FGF7 FGF9 HBEGF KIT LCK NRG1 NRG3 CD80 FGF1 FGF18 FGF8 FYN IRS1 PIK3R3 PTPN11 TRAT1

G2/M DNA Damage Checkpoint Processing Of DNA Double Strand Break Ends FDR = 7e−12%, FDR nod = 1.1%

unknown CG mut CDH1 FAT3 ARID1A PCDH19 PCDH15 SRCAP FAT1 CELSR2 CREBBP DCHS1 ITPR1 ITPR3 PCDHA1 PRKCQ CDH9 FAT2 ITPR2 PCDH10 PCDHA11 PCDHA5 EP300 HDAC1 PCDH9 PCDHA9 PCDHGA3 PLCB4 SMARCA2 TBL1XR1 CDH12 CDH2 CELSR3 PCDHA2 PCDHA7 PCDHGA1 SMARCA4 BCL9 CDH23 CDH8 CELSR1 CTNNA2 CTNNA3 PCDH11X PCDH12 PCDHA13 PCDHB1 PCDHB12 PCDHB16 PCDHB6 ANKRD6 CDH11 CDH18 CDH19 CTNNAL1 HDAC2 PCDH18 PCDHA3 PCDHA4 PCDHA6 PCDHA8 PCDHB15 PCDHB7 PCDHGA11 PCDHGA2 PRKCZ TLE1 CDH15 CDH16 CDH20 CDH24 CDH6 CDHR1 CDHR2 EP400 HDAC8 HLTF INO80 LRP6 NFATC4 PCDH7 PCDHA10 PCDHA12 PCDHAC2 PCDHB10 PCDHB13 PCDHB2 PCDHB3 PCDHB5 PCDHGA12 PCDHGA5 PCDHGA6 PCDHGB1 PCDHGB7 PCDHGC3 PPP3CA PPP3CB PRKCB PRKCD PRKCE SMAD4 SMARCC2 SMARCD1 WNT5B WNT7A ARR3 AXIN1 BTRC CDH10 CDH3 CDH7 CSNK1G3 CSNK2A2 CTNNB1 FZD3 FZD6 FZD8 FZD9 GNB1 GNB2 GSK3B HDAC3 MAP3K7 NLK PCDHB14 PCDHB4 PCDHB8 PCDHGA7 PCDHGB2 PCDHGB4 PLCB1 PLCB2 PLCB3 PPP2CB PPP2R5E SFRP1 SIAH1 SMAD5 SMARCAL1 SMARCC1 SMARCD3 TCF7L2 TLE3 WNT2 WNT3A WNT4 WNT5A WNT6 ARRB1 ARRB2 CDH13 CDH17 CDH4 CDH5 CER1 CSNK1A1L CSNK1E CSNK1G2 CTBP2 CTNNA1 DACT1 DVL1 DVL3 FZD1 FZD2 FZD5 FZD7 GNA14 GNAQ GNB3 GNG10 GNG4 KREMEN1 LRP5 NFATC2 NFATC3 NKD1 PCDH1 PCDH20 PCDHAC1 PCDHB11 PCDHGA10 PCDHGB6 PCDHGC4 PCDHGC5 PPP2CA PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP3CC PPP3R1 PPP3R2 PRKCA PRKCG PRKCH PRKCI SAG SFRP2 SFRP4 SMAD1 SMARCE1 TBL1X TCF7L1 TLE2 TLE4 WNT10A WNT10B WNT11 WNT16 WNT2B WNT8B WNT9A COL6A3

unknown CG mut

TCGA−E2− TCGA−BH−A1F2−01A−31D−A13L−09 TCGA−AO−A0JB−01A−11W−A071−09 TCGA−D8−A27K−01A−11D−A16D−09 TCGA−C8−A1HN−01A−11D−A135−09 SA096 BR−V−026 TCGA−A2−A0T0−01A−22D−A099−09 TCGA−E2−A152−01A−11D−A12B−09 TCGA−C8−A12Q−01A−11D−A10Y−09 TCGA−AR−A1AI−01A−11D−A12Q−09 SA106 CGP_donor_1329919 TCGA−EW−A1OY−01A−11D−A142−09 TCGA−BH−A1FC−01A−11D−A13L−09 BR−M−095 TCGA−E9−A1RH−01A−21D−A167−09 TCGA−D8−A1X6−01A−11D−A14K−09 TCGA−AR−A0TY−01A−12W−A12T−09 TCGA−A8−A090−01A−11W−A019−09 TCGA−A8−A08F−01A−11W−A019−09 TCGA−A7−A26J−01A−11D−A167−09 SA098 TCGA−EW−A1IY−01A−11D−A188−09 BB7T BB23T BB13T SA071 TCGA−AN−A0FV−01A−11W−A019−09 TCGA−A8−A07R−01A−21W−A050−09 TCGA−A2−A25D−01A−12D−A16D−09 SA210 SA069 BR−V−043 TCGA−EW−A1PD−01A−11D−A142−09 TCGA−A2−A0YM−01A−11D−A10G−09 TCGA−A2−A0T3−01A−21D−A10Y−09 SA228 CSB7 BR−M−085 CGP_donor_1212373 TCGA−BH−A204−01A−11D−A159−09 TCGA−E2−A1IG−01A−11D−A142−09 TCGA−B6−A0IB−01A−11W−A050−09 TCGA−AR−A1AU−01A−11D−A12Q−09 TCGA−A2−A1G4−01A−11D−A13L−09 BR−V−030 TCGA−C8−A1HO−01A−11D−A13L−09 TCGA−BH−A0EI−01A−11D−A10Y−09 TCGA−B6−A0X4−01A−11D−A10G−09 TCGA−B6−A0WZ−01A−11D−A10G−09 TCGA−B6−A0RV−01A−11D−A099−09 TCGA−B6−A0RI−01A−11W−A071−09 TCGA−AO−A03T−01A−21W−A050−09 TCGA−AN−A0XR−01A−11D−A10G−09 CGP_donor_1163910 CGP_donor_1163899 BR−M−047 CGP_donor_1230733 CGP_donor_1212366 CGP_donor_1212361 BRC3 TCGA−E9−A1NI−01A−11W−A16H−09 BR−M−116 TCGA−E2−A1BD−01A−11D−A12Q−09 TCGA−D8−A1XY−01A−11D−A14K−09 TCGA−D8−A1JN−01A−11D−A13L−09 TCGA−D8−A1JD−01A−11D−A13L−09 TCGA−BH−A0W7−01A−11D−A10Y−09 TCGA−BH−A0DL−01A−11D−A10Y−09 TCGA−A8−A0A9−01A−11W−A019−09 TCGA−A8−A06Q−01A−11W−A050−09 TCGA−A7−A26H−01A−11D−A167−09 CGP_donor_1310130 BRC7 BRC39 TCGA−E2−A1L8−01A−11D−A13L−09 TCGA−E2−A1IN−01A−11D−A13L−09 TCGA−E2−A15K−01A−11D−A12Q−09 TCGA−E2−A10B−01A−11D−A10M−09 TCGA−D8−A1JS−01A−11D−A13L−09 TCGA−D8−A1JP−01A−11D−A13L−09 TCGA−BH−A0HN−01A−11D−A099−09 TCGA−BH−A0DP−01A−21W−A071−09 TCGA−BH−A0DK−01A−21W−A071−09 TCGA−AR−A1AS−01A−11D−A12Q−09 TCGA−A8−A0A7−01A−11W−A019−09 TCGA−A8−A093−01A−11W−A019−09 TCGA−A8−A08L−01A−11W−A019−09 TCGA−A8−A081−01A−11W−A019−09 TCGA−A8−A07E−01A−11W−A050−09 TCGA−A8−A075−01A−11D−A099−09 TCGA−A2−A0SY−01A−31D−A099−09 TCGA−A2−A0EY−01A−11W−A050−09 TCGA−A2−A04P−01A−31D−A128−09 SA214 CSB1 CGP_donor_1234112 CGP_donor_1212378 CGP_donor_1212368 CGP_donor_1212360 BRC5 BR−V−034 BR−V−027 TCGA−EW−A1PE−01A−11D−A142−09 TCGA−EW−A1P0−01A−11D−A142−09 TCGA−EW−A1OV−01A−11D−A142−09 TCGA−EW−A1IW−01A−11D−A13L−09 TCGA−E9−A1RA−01A−11D−A14G−09 TCGA−E9−A1R4−01A−21D−A14G−09 TCGA−E9−A1NG−01A−21D−A14K−09 TCGA−E2−A1BC−01A−11D−A14G−09 TCGA−E2−A15C−01A−31D−A12B−09 TCGA−E2−A156−01A−11D−A12B−09 TCGA−E2−A14Y−01A−21D−A12B−09 TCGA−E2−A14V−01A−11D−A12B−09 TCGA−D8−A27P−01A−11D−A16D−09 TCGA−D8−A1XS−01A−11D−A14K−09 TCGA−D8−A1XM−01A−21D−A14K−09 TCGA−D8−A1XL−01A−11D−A14K−09 TCGA−D8−A1JJ−01A−31D−A14K−09 TCGA−D8−A146−01A−31D−A10Y−09 TCGA−C8−A274−01A−11D−A16D−09 TCGA−C8−A26X−01A−31D−A16D−09 TCGA−C8−A1HF−01A−11D−A135−09 TCGA−C8−A131−01A−11D−A10Y−09 TCGA−C8−A130−01A−31D−A10Y−09 TCGA−C8−A12Y−01A−11D−A12B−09 TCGA−C8−A12T−01A−11D−A10Y−09 TCGA−C8−A12L−01A−11D−A10Y−09 TCGA−BH−A208−01A−11D−A159−09 TCGA−BH−A203−01A−12D−A167−09 TCGA−BH−A202−01A−11D−A14K−09 TCGA−BH−A1FE−01A−11D−A13L−09 TCGA−BH−A1F8−01A−11D−A13L−09 TCGA−BH−A1EY−01A−11D−A13L−09 TCGA−BH−A1EU−01A−11D−A135−09 TCGA−BH−A18J−01A−11D−A12B−09 TCGA−BH−A18H−01A−11D−A12B−09 TCGA−BH−A18F−01A−11D−A12B−09 TCGA−BH−A0H9−01A−11W−A071−09 TCGA−BH−A0GY−01A−11W−A071−09 TCGA−BH−A0EA−01A−11D−A10Y−09 TCGA−BH−A0DX−01A−11D−A10Y−09 TCGA−B6−A0RH−01A−21D−A10Y−09 TCGA−B6−A0RG−01A−11W−A071−09 TCGA−B6−A0IE−01A−11W−A050−09 TCGA−AR−A24M−01A−11D−A167−09 TCGA−AR−A24K−01A−11D−A167−09 TCGA−AR−A1AL−01A−21D−A12Q−09 TCGA−AR−A0TR−01A−11D−A099−09 TCGA−AQ−A0Y5−01A−11D−A14K−09 TCGA−AO−A125−01A−11D−A10M−09 TCGA−AO−A0JF−01A−11W−A071−09 TCGA−AO−A03N−01B−11D−A10M−09 TCGA−AN−A0XO−01A−11D−A10G−09 TCGA−AN−A0FS−01A−11W−A050−09 TCGA−AN−A0AJ−01A−11W−A019−09 TCGA−AN−A03Y−01A−21W−A019−09 TCGA−AN−A03X−01A−21W−A019−09 TCGA−AC−A23E−01A−11D−A159−09 TCGA−AC−A23C−01A−12D−A167−09 TCGA−A8−A095−01A−11W−A019−09 TCGA−A8−A08B−01A−11W−A019−09 TCGA−A8−A07Z−01A−11W−A019−09 TCGA−A8−A06P−01A−11W−A019−09 TCGA−A7−A0D9−01A−31W−A071−09 TCGA−A7−A0CJ−01A−21W−A019−09 TCGA−A2−A25A−01A−12D−A16D−09 TCGA−A2−A1G0−01A−11D−A13L−09 TCGA−A2−A0YL−01A−21D−A10G−09 TCGA−A2−A0YK−01A−22D−A117−09 TCGA−A2−A0YH−01A−11D−A10G−09 TCGA−A2−A0EM−01A−11W−A050−09 TCGA−A2−A04V−01A−21W−A050−09 TCGA−A2−A04N−01A−11D−A10Y−09 TCGA−A1−A0SI−01A−11D−A142−09 SA218 SA056 CSB3 CSB27 CSB21 CSB15 CGP_donor_1310129 CGP_donor_1212369 CGP_donor_1163903 BRC50 BRC47 BRC4 BRC18 BRC15 BRC13 BR−V−064 BR−V−024 BR−M−050 TCGA−EW−A1J2−01A−21D−A13L−09 TCGA−EW−A1J1−01A−11D−A188−09 TCGA−EW−A1IX−01A−12D−A142−09 TCGA−E9−A295−01A−11D−A16D−09 TCGA−E9−A249−01A−11D−A167−09 TCGA−E9−A229−01A−31D−A17G−09 TCGA−E9−A227−01A−11D−A159−09 TCGA−E9−A226−01A−21D−A159−09 TCGA−E9−A1RI−01A−11D−A167−09 TCGA−E9−A1RE−01A−11D−A159−09 TCGA−E9−A1RD−01A−11D−A159−09 TCGA−E9−A1RC−01A−11D−A159−09 TCGA−E9−A1R5−01A−11D−A14K−09 TCGA−E9−A1R3−01A−31D−A14K−09 TCGA−E9−A1R0−01A−22D−A16D−09 TCGA−E9−A1NH−01A−11D−A14G−09 TCGA−E9−A1N5−01A−11D−A14G−09 TCGA−E2−A1L6−01A−11D−A13L−09 TCGA−E2−A1IO−01A−11D−A142−09 TCGA−E2−A1IL−01A−11D−A14G−09 TCGA−E2−A1IF−01A−11D−A142−09 TCGA−E2−A1B4−01A−11D−A12Q−09 TCGA−E2−A15P−01A−11D−A10Y−09 TCGA−E2−A15L−01A−11D−A12B−09 TCGA−E2−A15G−01A−11D−A12B−09 TCGA−E2−A15E−01A−11D−A12B−09 TCGA−E2−A154−01A−11D−A10Y−09 TCGA−E2−A153−01A−12D−A12B−09 TCGA−E2−A10F−01A−11D−A10M−09 TCGA−E2−A105−01A−11D−A10M−09 TCGA−D8−A27T−01A−11D−A16D−09 TCGA−D8−A27L−01A−11D−A16D−09 TCGA−D8−A1Y2−01A−11D−A159−09 TCGA−D8−A1Y1−01A−21D−A14K−09 TCGA−D8−A1XO−01A−11D−A14K−09 TCGA−D8−A1JU−01A−11D−A13L−09 TCGA−D8−A1JK−01A−11D−A13L−09 TCGA−D8−A1JH−01A−11D−A188−09 TCGA−D8−A1JF−01A−11D−A13L−09 TCGA−D8−A1JE−01A−11D−A13L−09 TCGA−D8−A143−01A−11D−A10Y−09 TCGA−C8−A278−01A−11D−A167−09 TCGA−C8−A26W−01A−11D−A16D−09 TCGA−C8−A1HE−01A−11D−A188−09 TCGA−C8−A133−01A−32D−A12B−09 TCGA−C8−A12U−01A−11D−A10Y−09 TCGA−C8−A12N−01A−11D−A10Y−09 TCGA−BH−A1ET−01A−11D−A135−09 TCGA−BH−A18M−01A−11D−A12B−09 TCGA−BH−A18I−01A−11D−A12B−09 TCGA−BH−A0W5−01A−11D−A10G−09 TCGA−BH−A0W3−01A−11D−A10G−09 TCGA−BH−A0HI−01A−11D−A099−09 TCGA−BH−A0H3−01A−11D−A12Q−09 TCGA−BH−A0EE−01A−11W−A050−09 TCGA−BH−A0EB−01A−11W−A050−09 TCGA−BH−A0DV−01A−21D−A12Q−09 TCGA−BH−A0DT−01A−21D−A12B−09 TCGA−BH−A0DO−01B−11D−A12B−09 TCGA−BH−A0DE−01A−11D−A10Y−09 TCGA−BH−A0DD−01A−31D−A12Q−09 TCGA−BH−A0BV−01A−11W−A019−09 TCGA−BH−A0BT−01A−11D−A12Q−09 TCGA−BH−A0BO−01A−23D−A12B−09 TCGA−BH−A0BM−01A−11W−A071−09 TCGA−BH−A0BF−01A−21D−A12Q−09 TCGA−BH−A0BD−01A−11W−A050−09 TCGA−BH−A0BC−01A−22D−A099−09 TCGA−BH−A0BA−01A−11W−A071−09 TCGA−BH−A0B0−01A−21D−A10Y−09 TCGA−B6−A1KI−01A−11D−A14K−09 TCGA−B6−A0X7−01A−11D−A10M−09 TCGA−B6−A0X5−01A−21D−A10G−09 TCGA−B6−A0WY−01A−11D−A10G−09 TCGA−B6−A0WW−01A−11D−A10G−09 TCGA−B6−A0RQ−01A−11D−A10Y−09 TCGA−B6−A0RP−01A−21D−A099−09 TCGA−B6−A0RO−01A−22D−A099−09 TCGA−B6−A0RN−01A−12D−A099−09 TCGA−B6−A0IP−01A−11D−A045−09 TCGA−B6−A0IK−01A−12W−A071−09 TCGA−B6−A0IC−01A−11W−A050−09 TCGA−B6−A0I5−01A−11W−A100−09 TCGA−AR−A255−01A−11D−A167−09 TCGA−AR−A24T−01A−11D−A167−09 TCGA−AR−A24S−01A−11D−A167−09 TCGA−AR−A24O−01A−11D−A167−09 TCGA−AR−A1AW−01A−21D−A12Q−09 TCGA−AR−A1AV−01A−21D−A12Q−09 TCGA−AR−A0TZ−01A−12D−A099−09 TCGA−AQ−A1H2−01A−11D−A13L−09 TCGA−AO−A1KR−01A−12D−A142−09 TCGA−AO−A12A−01A−21D−A10Y−09 TCGA−AO−A126−01A−11D−A10M−09 TCGA−AO−A0JE−01A−11W−A071−09 TCGA−AO−A0JA−01A−11W−A071−09 TCGA−AO−A0J7−01A−11W−A050−09 TCGA−AO−A0J5−01A−11W−A050−09 TCGA−AO−A03L−01A−41W−A071−09 TCGA−AN−A0XS−01A−22D−A10G−09 TCGA−AN−A0XP−01A−11D−A117−09 TCGA−AN−A0XL−01A−11D−A10M−09 TCGA−AN−A0FF−01A−11W−A050−09 TCGA−AN−A04C−01A−21W−A050−09 TCGA−AN−A049−01A−21W−A019−09 TCGA−A8−A0A1−01A−11W−A019−09 TCGA−A8−A09D−01A−11W−A019−09 TCGA−A8−A09C−01A−11W−A019−09 TCGA−A8−A096−01A−11W−A019−09 TCGA−A8−A092−01A−11W−A019−09 TCGA−A8−A08Z−01A−21W−A019−09 TCGA−A8−A08T−01A−21W−A019−09 TCGA−A8−A08R−01A−11W−A050−09 TCGA−A8−A08P−01A−11W−A019−09 TCGA−A8−A08O−01A−21W−A071−09 TCGA−A8−A084−01A−21W−A019−09 TCGA−A8−A07G−01A−11W−A050−09 TCGA−A8−A07B−01A−11W−A019−09 TCGA−A8−A06U−01A−11W−A019−09 TCGA−A8−A06R−01A−11D−A015−09 TCGA−A7−A26E−01A−11D−A167−09 TCGA−A7−A13G−01A−11D−A13L−09 TCGA−A7−A0DB−01A−11W−A019−09 TCGA−A7−A0CH−01A−21W−A019−09 TCGA−A7−A0CG−01A−11W−A019−09 TCGA−A2−A25C−01A−11D−A167−09 TCGA−A2−A1FZ−01A−51D−A17G−09 TCGA−A2−A0YT−01A−11D−A10G−09 TCGA−A2−A0YI−01A−31D−A10M−09 TCGA−A2−A0YC−01A−11D−A117−09 TCGA−A2−A0T7−01A−21D−A099−09 TCGA−A2−A0T4−01A−31D−A099−09 TCGA−A2−A0EX−01A−21W−A050−09 TCGA−A2−A0EW−01A−21D−A10Y−09 TCGA−A2−A0EV−01A−11W−A050−09 TCGA−A2−A0EQ−01A−11W−A050−09 TCGA−A2−A0EO−01A−11W−A050−09 TCGA−A2−A0EN−01A−13D−A099−09 TCGA−A2−A0D3−01A−11D−A10Y−09 TCGA−A2−A0D1−01A−11W−A050−09 TCGA−A2−A0CW−01A−21D−A10Y−09 TCGA−A2−A0CS−01A−11D−A10Y−09 TCGA−A2−A0CP−01A−11W−A050−09 TCGA−A2−A04W−01A−31D−A10Y−09 SA223 SA215 SA074 CSB6 CSB30 CSB26 CSB24 CSB17 CSB13 CSB12 CGP_donor_1329917 CGP_donor_1234117 CGP_donor_1230732 CGP_donor_1230726 CGP_donor_1212376 CGP_donor_1212367 CGP_donor_1212365 CGP_donor_1212363 CGP_donor_1199132 CGP_donor_1199130 CGP_donor_1195184 CGP_donor_1187021 CGP_donor_1186988 CGP_donor_1184344 CGP_donor_1184343 CGP_donor_1163909 CGP_donor_1163904 CGP_donor_1163900 CGP_donor_1163898 BRC9 BRC8 BRC52 BRC51 BRC40 BRC37 BRC36 BRC33 BRC31 BRC28 BRC24 BRC20 BRC11 BRC10 BR−V−071 BR−V−052 BR−V−021 BR−V−020 BR−V−015 BR−V−003 BR−M−184 BR−M−169 BR−M−166 BR−M−165 BR−M−158 BR−M−150 BR−M−121 BR−M−120 BR−M−098 BR−M−083 BR−M−059 BR−M−055 BR−M−036 BR−M−030 BR−M−028 BR−M−026

TCGA−AO−A1KS−01A−11D−A13L−09 CGP_donor_1212362 CGP_donor_1199128 TCGA−AO−A0J6−01A−11W−A050−09 CGP_donor_1329919 TCGA−A2−A0SV−01A−11D−A099−09 SA092 BR−M−027 TCGA−E9−A295−01A−11D−A16D−09 TCGA−B6−A0IB−01A−11W−A050−09 TCGA−AR−A251−01A−12D−A167−09 TCGA−D8−A1Y3−01A−11D−A159−09 TCGA−D8−A1JJ−01A−31D−A14K−09 TCGA−A7−A13D−01A−13D−A12Q−09 TCGA−E9−A1RH−01A−21D−A167−09 TCGA−E9−A1RA−01A−11D−A14G−09 TCGA−BH−A18S−01A−11D−A12B−09 TCGA−A2−A0T0−01A−22D−A099−09 TCGA−B6−A0X0−01A−21D−A10Y−09 TCGA−AR−A24H−01A−11D−A167−09 CGP_donor_1212371 CGP_donor_1199101 CGP_donor_1184341 TCGA−E2−A15M−01A−11D−A12B−09 TCGA−E2−A15K−01A−11D−A12Q−09 TCGA−D8−A1XY−01A−11D−A14K−09 TCGA−D8−A1JN−01A−11D−A13L−09 TCGA−A8−A085−01A−11W−A019−09 TCGA−E2−A14W−01A−11D−A12B−09 TCGA−A2−A0SX−01A−12D−A099−09 TCGA−A2−A04P−01A−31D−A128−09 SA075 BRC47 BR−V−054 TCGA−C8−A274−01A−11D−A16D−09 TCGA−BH−A18V−01A−11D−A12B−09 TCGA−AR−A24L−01A−11D−A167−09 TCGA−A2−A0SW−01A−11D−A099−09 SA223 CGP_donor_1199131 CGP_donor_1195183 TCGA−A8−A093−01A−11W−A019−09 TCGA−E2−A1LS−01A−12D−A159−09 TCGA−C8−A1HN−01A−11D−A135−09 TCGA−C8−A12U−01A−11D−A10Y−09 TCGA−BH−A1FR−01A−11D−A13L−09 TCGA−BH−A18M−01A−11D−A12B−09 TCGA−AO−A0J4−01A−11W−A050−09 TCGA−AN−A0XU−01A−11D−A10G−09 TCGA−A8−A08F−01A−11W−A019−09 TCGA−A2−A0YT−01A−11D−A10G−09 SA210 CGP_donor_1230735 BR−V−050 BR−M−184 CGP_donor_1212361 TCGA−E2−A1LH−01A−11D−A14G−09 TCGA−C8−A12P−01A−11D−A10Y−09 TCGA−BH−A1FE−01A−11D−A13L−09 TCGA−AR−A0TU−01A−31D−A10G−09 TCGA−AO−A0J9−01A−11W−A050−09 TCGA−AN−A0AR−01A−11W−A019−09 TCGA−AC−A23C−01A−12D−A167−09 TCGA−A8−A09Q−01A−11W−A019−09 TCGA−A8−A08L−01A−11W−A019−09 TCGA−A8−A07E−01A−11W−A050−09 TCGA−A8−A06Q−01A−11W−A050−09 TCGA−A2−A0ET−01A−31D−A045−09 CGP_donor_1163903 BRC16

RAF/MAP Kinase Cascade FDR = 0.07%, FDR nod = 3% P130Cas Linkage To MAPK Signaling For Integrins FDR = 5.5%, FDR nod = 3.3%

FN1

ITGB3

PTK2

APBB1IP

BCAR1

FGG

ITGA2B

RAP1B

CRK

FGB

TCGA−BH−A18U−01A−21D−A12B−09 TCGA−A7−A0D9−01A−31W−A071−09 TCGA−A8−A08J−01A−11W−A019−09 TCGA−BH−A1FD−01A−11W−A14Q−09 SA237 TCGA−E2−A1IK−01A−11D−A17G−09 TCGA−AR−A1AI−01A−11D−A12Q−09 TCGA−BH−A0B5−01A−11D−A12Q−09 TCGA−BH−A0AW−01A−11W−A071−09 TCGA−D8−A1JD−01A−11D−A13L−09 TCGA−B6−A0RS−01A−11D−A099−09 CGP_donor_1212373 TCGA−A8−A08P−01A−11W−A019−09 CGP_donor_1230730 BR−V−034 TCGA−A8−A09I−01A−22W−A050−09 TCGA−AN−A0FS−01A−11W−A050−09 TCGA−A7−A0CG−01A−11W−A019−09 TCGA−AR−A0TY−01A−12W−A12T−09 TCGA−E2−A14Z−01A−11D−A10Y−09 BR−V−036 TCGA−C8−A134−01A−11D−A10Y−09 CGP_donor_1163900 TCGA−A2−A25A−01A−12D−A16D−09 SA092 TCGA−BH−A201−01A−11D−A14K−09 TCGA−B6−A0RH−01A−21D−A10Y−09 TCGA−BH−A0E1−01A−11W−A071−09 CSB25 TCGA−E2−A1IF−01A−11D−A142−09 TCGA−AR−A1AL−01A−21D−A12Q−09 TCGA−C8−A12O−01A−11D−A10Y−09 TCGA−A1−A0SF−01A−11D−A142−09 TCGA−A2−A0EN−01A−13D−A099−09 BR−V−048 TCGA−E2−A158−01A−11D−A12B−09 CGP_donor_1212372 TCGA−A2−A0D1−01A−11W−A050−09 CGP_donor_1199131 TCGA−AO−A0J6−01A−11W−A050−09 CGP_donor_1329919 TCGA−AN−A0FN−01A−11W−A050−09 SA214 SA074 BRC7 TCGA−BH−A0DI−01A−21D−A12Q−09 BR−M−155 TCGA−BH−A0HP−01A−12D−A099−09 TCGA−B6−A1KN−01A−11D−A13L−09 TCGA−BH−A0C0−01A−21W−A071−09 TCGA−AN−A0G0−01A−11W−A050−09 TCGA−E2−A14R−01A−11D−A10Y−09 TCGA−A2−A0YC−01A−11D−A117−09 TCGA−A8−A075−01A−11D−A099−09 CGP_donor_1199134 BR−M−038 BR−M−172 TCGA−EW−A1PE−01A−11D−A142−09 TCGA−BH−A1F5−01A−12D−A13L−09 TCGA−BH−A0B0−01A−21D−A10Y−09 TCGA−AN−A0AM−01A−11W−A050−09 BR−M−059 TCGA−E9−A1RH−01A−21D−A167−09 TCGA−E9−A1RA−01A−11D−A14G−09 TCGA−BH−A18S−01A−11D−A12B−09 TCGA−D8−A1JE−01A−11D−A13L−09 TCGA−A2−A0D3−01A−11D−A10Y−09 BR−V−067 TCGA−E2−A1IN−01A−11D−A13L−09 SA098 SA031 TCGA−EW−A1P4−01A−21D−A142−09 TCGA−AR−A1AK−01A−21D−A12Q−09 TCGA−A2−A1FW−01A−11D−A13L−09 TCGA−A2−A0SY−01A−31D−A099−09 TCGA−AR−A24S−01A−11D−A167−09 BR−M−073 TCGA−A8−A0AD−01A−11W−A071−09 TCGA−AN−A04C−01A−21W−A050−09 TCGA−A2−A0EY−01A−11W−A050−09 TCGA−C8−A1HN−01A−11D−A135−09 TCGA−A8−A06X−01A−21W−A019−09 CSB9 TCGA−AR−A24K−01A−11D−A167−09 TCGA−AN−A0FW−01A−11W−A050−09 TCGA−A8−A08O−01A−21W−A071−09 TCGA−D8−A147−01A−11D−A10Y−09 TCGA−C8−A1HE−01A−11D−A188−09 TCGA−B6−A0IB−01A−11W−A050−09 BRC15 CGP_donor_1212364 TCGA−BH−A1FN−01A−11D−A13L−09 TCGA−A2−A0D4−01A−11W−A019−09 TCGA−A2−A0D2−01A−21W−A050−09 CGP_donor_1230756 TCGA−E2−A15L−01A−11D−A12B−09 TCGA−C8−A26V−01A−11D−A16D−09 CGP_donor_1329921 BR−V−037 TCGA−D8−A27I−01A−11D−A16D−09 TCGA−AR−A250−01A−31D−A167−09 TCGA−A2−A04Y−01A−21W−A050−09 TCGA−E9−A1R7−01A−11D−A14K−09 TCGA−BH−A1EY−01A−11D−A13L−09 TCGA−A8−A08T−01A−21W−A019−09 SA225 TCGA−E2−A1B5−01A−21D−A12Q−09 TCGA−E2−A10E−01A−21D−A10M−09 TCGA−AR−A1AO−01A−11D−A12Q−09 BB28T TCGA−D8−A1JL−01A−11D−A13L−09 TCGA−A2−A0YT−01A−11D−A10G−09 TCGA−A1−A0SH−01A−11D−A099−09 CGP_donor_1234119 BRC8 CGP_donor_1212376 TCGA−C8−A12U−01A−11D−A10Y−09 TCGA−AO−A03T−01A−21W−A050−09 TCGA−A8−A0A7−01A−11W−A019−09 TCGA−A8−A08R−01A−11W−A050−09 TCGA−BH−A0H9−01A−11W−A071−09 TCGA−AO−A03N−01B−11D−A10M−09 TCGA−A2−A0CX−01A−21W−A019−09 SA072 BR−V−002 TCGA−A8−A085−01A−11W−A019−09 TCGA−A8−A07R−01A−21W−A050−09 TCGA−D8−A1XT−01A−11D−A14K−09 TCGA−E2−A159−01A−11D−A10Y−09 TCGA−E2−A14T−01A−11D−A10Y−09 TCGA−D8−A1XF−01A−11D−A14G−09 TCGA−E2−A14W−01A−11D−A12B−09 CGP_donor_1212361 TCGA−A2−A0SX−01A−12D−A099−09 SA075 BRC47 BR−V−054 TCGA−A8−A09A−01A−11W−A019−09 TCGA−A8−A095−01A−11W−A019−09 BRC39 BRC33 TCGA−AN−A04A−01A−21W−A050−09 TCGA−A8−A07G−01A−11W−A050−09 TCGA−E2−A15E−01A−11D−A12B−09 TCGA−D8−A1XZ−01A−11D−A14K−09 TCGA−D8−A13Z−01A−11D−A10Y−09 TCGA−AN−A04D−01A−21W−A050−09 TCGA−A2−A1G0−01A−11D−A13L−09 BR−M−005 TCGA−AN−A0FL−01A−11W−A050−09 TCGA−GI−A2C8−01A−11D−A16D−09 TCGA−E9−A1NA−01A−11D−A142−09 TCGA−E2−A15K−01A−11D−A12Q−09 TCGA−A8−A09X−01A−11W−A019−09 TCGA−A8−A084−01A−21W−A019−09 TCGA−A2−A0T0−01A−22D−A099−09 TCGA−AR−A1AV−01A−21D−A12Q−09 TCGA−AO−A12D−01A−11D−A10Y−09 CGP_donor_1230732 CGP_donor_1187032 CGP_donor_1163915 BRC31 BR−V−014 TCGA−D8−A1JF−01A−11D−A13L−09 TCGA−C8−A1HG−01A−11D−A135−09 TCGA−AR−A0TV−01A−21D−A099−09 TCGA−AO−A12G−01A−11D−A10M−09 TCGA−A8−A094−01A−11W−A019−09 SA213 BR−M−110 TCGA−C8−A131−01A−11D−A10Y−09 TCGA−BH−A18T−01A−11D−A12B−09 TCGA−BH−A0BP−01A−11D−A10Y−09 TCGA−AO−A125−01A−11D−A10M−09 TCGA−E2−A1BD−01A−11D−A12Q−09 TCGA−E2−A15C−01A−31D−A12B−09 TCGA−D8−A27P−01A−11D−A16D−09 TCGA−BH−A0BG−01A−11D−A10Y−09 TCGA−AO−A129−01A−21D−A10M−09 TCGA−BH−A0EE−01A−11W−A050−09 TCGA−B6−A0RG−01A−11W−A071−09 TCGA−E2−A150−01A−11D−A12B−09 TCGA−AN−A0AT−01A−11D−A045−09 TCGA−A8−A08A−01A−11W−A019−09 SA056 CGP_donor_1212367 CGP_donor_1199106 CGP_donor_1199103 BR−M−079 BR−V−043 CGP_donor_1234118 CGP_donor_1195183 BB23T TCGA−D8−A27M−01A−11D−A16D−09 TCGA−BH−A0BW−01A−11D−A10Y−09 TCGA−A2−A0T1−01A−21D−A099−09 CGP_donor_1230735 BB9T BB27T BB13T TCGA−AN−A0XU−01A−11D−A10G−09 SA069 TCGA−E9−A244−01A−11D−A167−09 TCGA−D8−A1XL−01A−11D−A14K−09 TCGA−E2−A1LL−01A−11D−A142−09 TCGA−C8−A1HL−01A−11D−A135−09 TCGA−AO−A03P−01A−11W−A019−09 TCGA−A2−A04V−01A−21W−A050−09 TCGA−A1−A0SB−01A−11D−A142−09 CSB28 CSB2 CGP_donor_1163916 BR−M−191 TCGA−C8−A12T−01A−11D−A10Y−09 TCGA−AN−A0FX−01A−11W−A050−09 SA218 CGP_donor_1163913 TCGA−C8−A26Z−01A−11D−A16D−09 TCGA−BH−A1F8−01A−11D−A13L−09 TCGA−BH−A0W7−01A−11D−A10Y−09 TCGA−B6−A0IK−01A−12W−A071−09 TCGA−AO−A12A−01A−21D−A10Y−09 TCGA−AN−A0FV−01A−11W−A019−09 SA030 CGP_donor_1234116 CGP_donor_1230725 TCGA−D8−A1J9−01A−11D−A13L−09 TCGA−D8−A1JC−01A−11D−A13L−09 TCGA−A8−A08L−01A−11W−A019−09 TCGA−E2−A14S−01A−11D−A12B−09 TCGA−D8−A140−01A−11D−A10Y−09 TCGA−BH−A0DE−01A−11D−A10Y−09 TCGA−B6−A0X1−01A−11D−A10G−09 TCGA−B6−A0IJ−01A−11W−A050−09 TCGA−AR−A0U4−01A−11D−A117−09 TCGA−AR−A0TW−01A−11D−A099−09 SA219 CSB26 BR−V−013 BR−M−167 TCGA−A8−A06Z−01A−11W−A019−09 TCGA−EW−A1PD−01A−11D−A142−09 TCGA−E9−A1R5−01A−11D−A14K−09 TCGA−C8−A135−01A−11D−A10Y−09 TCGA−A2−A0T6−01A−11D−A099−09 SA065 BR−V−060 BR−M−095 TCGA−D8−A1XM−01A−21D−A14K−09 TCGA−C8−A274−01A−11D−A16D−09 TCGA−BH−A1FE−01A−11D−A13L−09 TCGA−BH−A0C1−01B−11D−A12B−09 TCGA−A8−A0AB−01A−11W−A050−09 TCGA−A8−A08Z−01A−21W−A019−09 SA096 BRC14 BR−M−094 TCGA−A2−A04P−01A−31D−A128−09 TCGA−BH−A18V−01A−11D−A12B−09 TCGA−A8−A07C−01A−11D−A045−09 CSB1 CGP_donor_1230733 CGP_donor_1199101 TCGA−E2−A155−01A−11D−A12B−09 TCGA−E2−A14N−01A−31D−A135−09 TCGA−D8−A27R−01A−11D−A16D−09 TCGA−D8−A27N−01A−11D−A16D−09 TCGA−D8−A1XY−01A−11D−A14K−09 TCGA−B6−A0RV−01A−11D−A099−09 TCGA−A8−A092−01A−11W−A019−09 TCGA−A2−A0YM−01A−11D−A10G−09 TCGA−A1−A0SN−01A−11D−A142−09 SA210 CGP_donor_1163918 BB5T TCGA−AO−A124−01A−11D−A10M−09 TCGA−E9−A1NG−01A−21D−A14K−09 TCGA−D8−A1X9−01A−12D−A159−09 TCGA−D8−A1JN−01A−11D−A13L−09 TCGA−AR−A251−01A−12D−A167−09 TCGA−AR−A24Q−01A−12D−A167−09 TCGA−AR−A1AS−01A−11D−A12Q−09 TCGA−AO−A0J3−01A−11W−A050−09 TCGA−A8−A09N−01A−11W−A019−09 TCGA−A8−A08F−01A−11W−A019−09 BRC50 BR−M−027 TCGA−E9−A229−01A−31D−A17G−09 TCGA−E9−A1RE−01A−11D−A159−09 TCGA−D8−A1X6−01A−11D−A14K−09 TCGA−C8−A12Q−01A−11D−A10Y−09 TCGA−C8−A12L−01A−11D−A10Y−09 TCGA−BH−A1FU−01A−11D−A14G−09 TCGA−BH−A1F2−01A−31D−A13L−09 TCGA−BH−A1EV−01A−11D−A135−09 TCGA−B6−A0I8−01A−11W−A050−09 TCGA−AR−A1AQ−01A−11D−A12Q−09 TCGA−AO−A1KR−01A−12D−A142−09 TCGA−AO−A0JB−01A−11W−A071−09 TCGA−A8−A08I−01A−11W−A019−09 TCGA−A2−A0CM−01A−31W−A050−09 SA230 CSB5 CGP_donor_1212362

TCGA−AO−A1KS−01A−11D−A13L−09 TCGA−AR−A24X−01A−11D−A167−09 CGP_donor_1212362 CGP_donor_1199128 TCGA−A2−A0SV−01A−11D−A099−09 SA092 BR−M−027 TCGA−E9−A295−01A−11D−A16D−09 TCGA−B6−A0IB−01A−11W−A050−09 TCGA−AR−A251−01A−12D−A167−09 TCGA−E9−A1RF−01A−11D−A159−09 TCGA−D8−A1JD−01A−11D−A13L−09 BR−V−048 TCGA−D8−A1Y3−01A−11D−A159−09 TCGA−D8−A1JJ−01A−31D−A14K−09 TCGA−A7−A13D−01A−13D−A12Q−09 TCGA−E9−A1RH−01A−21D−A167−09 TCGA−E9−A1RA−01A−11D−A14G−09 TCGA−BH−A18S−01A−11D−A12B−09 TCGA−A2−A0T0−01A−22D−A099−09 TCGA−B6−A0X0−01A−21D−A10Y−09 TCGA−AR−A24H−01A−11D−A167−09 CGP_donor_1212371 CGP_donor_1199101 CGP_donor_1184341 TCGA−E2−A15M−01A−11D−A12B−09 TCGA−E2−A15K−01A−11D−A12Q−09 TCGA−D8−A1XY−01A−11D−A14K−09 TCGA−D8−A1JN−01A−11D−A13L−09 TCGA−A8−A085−01A−11W−A019−09 TCGA−C8−A274−01A−11D−A16D−09 TCGA−BH−A18V−01A−11D−A12B−09 TCGA−AR−A24L−01A−11D−A167−09 TCGA−A2−A0SW−01A−11D−A099−09 SA223 CGP_donor_1199131 CGP_donor_1195183 TCGA−A8−A093−01A−11W−A019−09 TCGA−E2−A1LS−01A−12D−A159−09 TCGA−C8−A1HN−01A−11D−A135−09 TCGA−C8−A12U−01A−11D−A10Y−09 TCGA−BH−A1FR−01A−11D−A13L−09 TCGA−BH−A18M−01A−11D−A12B−09 TCGA−AO−A0J4−01A−11W−A050−09 TCGA−AN−A0XU−01A−11D−A10G−09 TCGA−A8−A08F−01A−11W−A019−09 TCGA−A2−A0YT−01A−11D−A10G−09 SA210 CGP_donor_1230735 BR−V−050 BR−M−184 TCGA−E2−A1LH−01A−11D−A14G−09 TCGA−C8−A12P−01A−11D−A10Y−09 TCGA−BH−A1FE−01A−11D−A13L−09 TCGA−AR−A0TU−01A−31D−A10G−09 TCGA−AO−A0J9−01A−11W−A050−09 TCGA−AN−A0AR−01A−11W−A019−09 TCGA−AC−A23C−01A−12D−A167−09 TCGA−A8−A09Q−01A−11W−A019−09 TCGA−A8−A08L−01A−11W−A019−09 TCGA−A8−A07E−01A−11W−A050−09 TCGA−A8−A06Q−01A−11W−A050−09 TCGA−A2−A0ET−01A−31D−A045−09 CGP_donor_1212361 CGP_donor_1163903 BRC16

Inflammation Mediated By Chemokine And Cytokine Signaling Pathway FDR = 7e−12%, FDR nod = 0.036% IL 6 Type Cytokine Receptor Ligand Interactions FDR = 0.16%, FDR nod = 0.6%

unknown CG mut LIFR

JAK2

IL6ST

JAK1

TYK2

IL11RA

IL12A

IL12RB2

CNTFR

IL27

LIF

CLCF1

CNTF

IL11

wt wt OSMR

known HCG mut known HCG mut IL27RA

wt wt


TCGA−D8−A27F−01A−11D−A16D−09 CGP_donor_1212368 TCGA−D8−A27R−01A−11D−A16D−09 TCGA−AR−A0TP−01A−11D−A099−09 TCGA−AN−A0FX−01A−11W−A050−09 TCGA−E2−A14N−01A−31D−A135−09 TCGA−AR−A256−01A−11D−A167−09 TCGA−B6−A1KI−01A−11D−A14K−09 TCGA−A1−A0SD−01A−11D−A10Y−09 TCGA−BH−A209−01A−11D−A17G−09 CGP_donor_1199128 CGP_donor_1195183 TCGA−AR−A1AV−01A−21D−A12Q−09 BR−V−031 BR−M−155 TCGA−EW−A1P7−01A−21D−A142−09 TCGA−A8−A07B−01A−11W−A019−09 TCGA−A2−A0T2−01A−11W−A097−09 TCGA−E9−A1NC−01A−12W−A16L−09 TCGA−E2−A1L8−01A−11D−A13L−09 TCGA−BH−A1EO−01A−11D−A135−09 TCGA−BH−A1EN−01A−11D−A17G−09 TCGA−D8−A13Z−01A−11D−A10Y−09 TCGA−C8−A131−01A−11D−A10Y−09 TCGA−AO−A03O−01A−11W−A019−09 TCGA−A2−A25A−01A−12D−A16D−09 TCGA−E9−A1R7−01A−11D−A14K−09 TCGA−BH−A1EY−01A−11D−A13L−09 TCGA−A8−A095−01A−11W−A019−09 TCGA−A8−A08T−01A−21W−A019−09 SA225 TCGA−GI−A2C8−01A−11D−A16D−09 TCGA−D8−A1JL−01A−11D−A13L−09 TCGA−C8−A12X−01A−11D−A10Y−09 TCGA−BH−A0WA−01A−11D−A10G−09 TCGA−AR−A251−01A−12D−A167−09 TCGA−AO−A129−01A−21D−A10M−09 TCGA−E2−A1L6−01A−11D−A13L−09 TCGA−B6−A0RG−01A−11W−A071−09 TCGA−AO−A0J9−01A−11W−A050−09 TCGA−A8−A094−01A−11W−A019−09 TCGA−A8−A08B−01A−11W−A019−09 BR−M−028 TCGA−A8−A08L−01A−11W−A019−09 TCGA−BH−A0AW−01A−11W−A071−09 TCGA−AO−A125−01A−11D−A10M−09 TCGA−A8−A09A−01A−11W−A019−09 TCGA−A8−A07R−01A−21W−A050−09 BR−V−043 BR−M−172 TCGA−E9−A1R4−01A−21D−A14G−09 TCGA−D8−A1JN−01A−11D−A13L−09 TCGA−BH−A0HP−01A−12D−A099−09 TCGA−BH−A0BO−01A−23D−A12B−09 TCGA−B6−A1KF−01A−11D−A13L−09 TCGA−B6−A0IK−01A−12W−A071−09 CGP_donor_1234117 BR−V−060

TCGA−B6−A0WX−01A−11D−A10G−09 TCGA−BH−A0E0−01A−11W−A071−09 TCGA−BH−A18S−01A−11D−A12B−09 TCGA−BH−A1F5−01A−12D−A13L−09 TCGA−BH−A201−01A−11D−A14K−09 TCGA−A2−A25B−01A−11D−A167−09 BRC23 TCGA−E2−A1IU−01A−11D−A14G−09 CGP_donor_1163913 BRC42 TCGA−E9−A243−01A−21D−A167−09 TCGA−AN−A0AM−01A−11W−A050−09 TCGA−A2−A0SW−01A−11D−A099−09 CGP_donor_1163918 TCGA−A2−A0CX−01A−21W−A019−09 SA031 TCGA−A7−A0DA−01A−31D−A10Y−09 TCGA−A8−A07L−01A−11W−A019−09 TCGA−BH−A0E1−01A−11W−A071−09 TCGA−BH−A0B1−01A−12W−A071−09 TCGA−E2−A1LH−01A−11D−A14G−09 TCGA−B6−A0I2−01A−11W−A050−09 TCGA−AN−A0AT−01A−11D−A045−09 TCGA−BH−A1FJ−01A−11D−A13L−09 TCGA−E2−A15R−01A−11D−A10Y−09 SA229 TCGA−AR−A24R−01A−11D−A167−09 TCGA−A2−A0YJ−01A−11D−A10G−09 TCGA−BH−A0H7−01A−13W−A071−09 TCGA−A2−A1FV−01A−11D−A13L−09 TCGA−A2−A04R−01A−41D−A117−09 TCGA−AR−A251−01A−12D−A167−09 TCGA−A8−A097−01A−11W−A050−09 TCGA−E2−A1LK−01A−21D−A14G−09 TCGA−B6−A0RV−01A−11D−A099−09 TCGA−E9−A1R2−01A−11D−A14G−09 TCGA−BH−A0E6−01A−11W−A050−09 CGP_donor_1234118 BRC6 TCGA−A2−A0SU−01A−11D−A099−09 BR−V−002 TCGA−E2−A1LG−01A−21D−A14K−09 TCGA−A8−A08S−01A−11W−A050−09 TCGA−E9−A248−01A−11D−A167−09 TCGA−A8−A06T−01A−11W−A019−09 TCGA−AO−A0J2−01A−11W−A050−09 BR−V−009 TCGA−AO−A1KS−01A−11D−A13L−09 TCGA−AN−A0FT−01A−11W−A050−09 TCGA−E9−A1NC−01A−12W−A16L−09 SA089 TCGA−D8−A1JG−01B−11D−A13L−09 TCGA−A8−A08H−01A−21W−A019−09 TCGA−A8−A09X−01A−11W−A019−09 CGP_donor_1230725 SA234 SA077 TCGA−D8−A1X5−01A−11D−A14G−09 TCGA−C8−A27B−01A−11D−A167−09 TCGA−BH−A0B5−01A−11D−A12Q−09 BR−V−014 TCGA−EW−A1P8−01A−11D−A142−09 TCGA−B6−A0I9−01A−11W−A050−09 TCGA−A7−A26J−01A−11D−A167−09 BR−M−073 TCGA−B6−A1KF−01A−11D−A13L−09 TCGA−A1−A0SM−01A−11D−A099−09 TCGA−A8−A07J−01A−11W−A019−09 TCGA−A2−A0CU−01A−12W−A050−09 TCGA−C8−A1HK−01A−21D−A13L−09 BR−M−037 TCGA−AO−A03O−01A−11W−A019−09 CSB16 TCGA−D8−A145−01A−11D−A10Y−09 TCGA−BH−A0B4−01A−11W−A019−09 TCGA−BH−A0AV−01A−31D−A10Y−09 TCGA−A1−A0SJ−01A−11D−A099−09 TCGA−BH−A0C0−01A−21W−A071−09 TCGA−AN−A0G0−01A−11W−A050−09 TCGA−B6−A0RL−01A−11D−A099−09 TCGA−AR−A0TU−01A−31D−A10G−09 TCGA−AO−A0JJ−01A−11W−A071−09 BR−V−032 TCGA−A7−A13F−01A−11D−A12Q−09 TCGA−EW−A1J3−01A−11D−A13L−09 TCGA−A2−A0D0−01A−11W−A019−09 TCGA−E2−A108−01A−13D−A10M−09 TCGA−A2−A0T2−01A−11W−A097−09 CGP_donor_1163902 CGP_donor_1212373 BR−V−013 BR−V−011 TCGA−AR−A1AQ−01A−11D−A12Q−09 TCGA−A8−A07C−01A−11D−A045−09 TCGA−A2−A0SV−01A−11D−A099−09 TCGA−D8−A27R−01A−11D−A16D−09 SA213 BR−V−023 TCGA−A8−A076−01A−21W−A019−09 CSB28 CGP_donor_1163919 TCGA−AR−A24P−01A−11D−A167−09 TCGA−AO−A1KT−01A−11D−A13L−09 TCGA−AO−A0J9−01A−11W−A050−09 TCGA−BH−A0AW−01A−11W−A071−09 TCGA−A8−A09A−01A−11W−A019−09 BR−M−172 TCGA−BH−A18Q−01A−12D−A12B−09 TCGA−AR−A0TP−01A−11D−A099−09 TCGA−AN−A0XT−01A−11D−A10G−09 TCGA−BH−A1F6−01A−11D−A13L−09 TCGA−AO−A0JM−01A−21W−A071−09 CGP_donor_1199129 TCGA−A2−A0SX−01A−12D−A099−09 TCGA−E2−A14W−01A−11D−A12B−09 SA075 BR−V−054 TCGA−A2−A25E−01A−11D−A167−09 TCGA−B6−A0IN−01A−11W−A050−09 CGP_donor_1230727 CGP_donor_1199101 TCGA−AR−A1AT−01A−11D−A12Q−09 TCGA−D8−A27N−01A−11D−A16D−09 SA084 CGP_donor_1212362 CGP_donor_1212375 TCGA−BH−A0HX−01A−21W−A071−09 TCGA−AR−A24H−01A−11D−A167−09 TCGA−A8−A085−01A−11W−A019−09 TCGA−AR−A252−01A−11D−A167−09 TCGA−A8−A06Z−01A−11W−A019−09 SA101 CGP_donor_1163916 TCGA−A1−A0SH−01A−11D−A099−09 TCGA−A1−A0SD−01A−11D−A10Y−09 BR−M−126 CGP_donor_1163917 BR−V−067 TCGA−BH−A0HB−01A−11W−A071−09 TCGA−AO−A0J6−01A−11W−A050−09 TCGA−A8−A091−01A−11W−A019−09 CGP_donor_1199133 TCGA−EW−A1PB−01A−11D−A142−09 TCGA−B6−A0X1−01A−11D−A10G−09 TCGA−B6−A0RS−01A−11D−A099−09 TCGA−A1−A0SO−01A−22D−A099−09 CSB33 TCGA−E2−A1B0−01A−11D−A12Q−09 CGP_donor_1199131 BR−M−174 TCGA−A2−A1FX−01A−11D−A13L−09 BR−M−027 TCGA−D8−A27F−01A−11D−A16D−09 TCGA−A8−A06X−01A−21W−A019−09 TCGA−D8−A1XZ−01A−11D−A14K−09 TCGA−A7−A13D−01A−13D−A12Q−09 CGP_donor_1329920 TCGA−E2−A1LS−01A−12D−A159−09 TCGA−C8−A1HN−01A−11D−A135−09 TCGA−BH−A1FR−01A−11D−A13L−09 TCGA−A8−A08F−01A−11W−A019−09 TCGA−AO−A0J4−01A−11W−A050−09 BR−V−050 TCGA−E9−A22D−01A−11D−A159−09 TCGA−C8−A132−01A−31D−A10Y−09 TCGA−AN−A04A−01A−21W−A050−09 CGP_donor_1199074 TCGA−B6−A0IJ−01A−11W−A050−09 CGP_donor_1329921 TCGA−AN−A0XN−01A−21D−A10G−09 TCGA−AR−A256−01A−11D−A167−09 BR−M−041 TCGA−A8−A0AB−01A−11W−A050−09 TCGA−A8−A09Q−01A−11W−A019−09 SA225 TCGA−BH−A0BZ−01A−31D−A12Q−09 TCGA−D8−A1JM−01A−11D−A13L−09 TCGA−D8−A13Y−01A−11D−A10Y−09 TCGA−BH−A0BP−01A−11D−A10Y−09 TCGA−AO−A12F−01A−11D−A10Y−09 CGP_donor_1184337 TCGA−BH−A18U−01A−21D−A12B−09 TCGA−BH−A0DH−01A−11D−A099−09 TCGA−E2−A1II−01A−11D−A142−09 TCGA−BH−A0EI−01A−11D−A10Y−09 TCGA−AO−A12D−01A−11D−A10Y−09 TCGA−AN−A0FY−01A−11W−A050−09 BR−M−079 BR−M−191 TCGA−C8−A275−01A−21D−A16D−09 SA220 SA098 SA083 TCGA−AO−A0J3−01A−11W−A050−09 SA018 TCGA−A2−A0CT−01A−31W−A071−09 TCGA−E2−A1L7−01A−11D−A142−09 TCGA−BH−A0HY−01A−11W−A071−09 TCGA−A8−A09R−01A−11W−A019−09 TCGA−A8−A09M−01A−11W−A019−09 SA097 SA090 BR−M−123 CGP_donor_1329919 TCGA−E2−A152−01A−11D−A12B−09 TCGA−AR−A1AI−01A−11D−A12Q−09 TCGA−A2−A0T0−01A−22D−A099−09 SA106 TCGA−EW−A1OY−01A−11D−A142−09 TCGA−C8−A12Q−01A−11D−A10Y−09 TCGA−BH−A1FC−01A−11D−A13L−09 BR−M−095 TCGA−AO−A124−01A−11D−A10M−09 TCGA−AN−A0XU−01A−11D−A10G−09 CSB34 TCGA−E9−A1NF−01A−11D−A14G−09 TCGA−C8−A138−01A−11D−A10Y−09 TCGA−BH−A0DS−01A−11W−A071−09 TCGA−AR−A254−01A−21D−A167−09 TCGA−AR−A1AH−01A−11D−A12B−09 TCGA−AN−A0FJ−01A−11W−A019−09 CGP_donor_1212359 TCGA−AR−A0U4−01A−11D−A117−09 TCGA−A8−A09W−01A−11W−A019−09 TCGA−BH−A1EO−01A−11D−A135−09 TCGA−AN−A0FX−01A−11W−A050−09 CGP_donor_1199128 CGP_donor_1187029 TCGA−EW−A1P6−01A−11D−A142−09 TCGA−E2−A1IG−01A−11D−A142−09 TCGA−D8−A140−01A−11D−A10Y−09 TCGA−A8−A09B−01A−11W−A019−09 SA224 CGP_donor_1199106 TCGA−D8−A1JC−01A−11D−A13L−09 TCGA−A2−A0D2−01A−21W−A050−09 TCGA−E9−A1RF−01A−11D−A159−09 TCGA−E9−A1R7−01A−11D−A14K−09 TCGA−D8−A27H−01A−11D−A16D−09 TCGA−D8−A1JL−01A−11D−A13L−09 TCGA−AR−A24Z−01A−11D−A167−09 SA054 TCGA−D8−A1Y0−01A−11D−A14K−09 TCGA−D8−A1XJ−01A−11D−A14K−09 TCGA−C8−A12O−01A−11D−A10Y−09 TCGA−BH−A1EN−01A−11D−A17G−09 TCGA−BH−A0HU−01A−11W−A050−09 TCGA−A8−A07R−01A−21W−A050−09 SA071 TCGA−A2−A25D−01A−12D−A16D−09 SA210 SA069 TCGA−EW−A1PD−01A−11D−A142−09 BR−V−043 BR−M−085 TCGA−AN−A0FV−01A−11W−A019−09 TCGA−A2−A0YM−01A−11D−A10G−09 TCGA−A2−A0T3−01A−21D−A10Y−09 SA228 CSB7 TCGA−A7−A26F−01A−21D−A167−09 TCGA−E2−A1IH−01A−11D−A188−09 TCGA−BH−A0HP−01A−12D−A099−09 TCGA−AR−A24Q−01A−12D−A167−09 TCGA−AN−A0XW−01A−11D−A10G−09 TCGA−E2−A1LL−01A−11D−A142−09 TCGA−B6−A0WT−01A−11D−A10G−09 TCGA−B6−A0IB−01A−11W−A050−09 TCGA−A7−A26G−01A−21D−A167−09 SA216 TCGA−E2−A14Z−01A−11D−A10Y−09 TCGA−D8−A1JI−01A−11D−A13L−09 TCGA−D8−A13Z−01A−11D−A10Y−09 TCGA−BH−A1FN−01A−11D−A13L−09 TCGA−BH−A0H5−01A−21D−A10Y−09 TCGA−BH−A0GZ−01A−11W−A071−09 TCGA−BH−A0E9−01B−11D−A10Y−09 TCGA−B6−A0IO−01A−11W−A050−09 TCGA−AR−A24W−01A−11D−A17G−09 TCGA−AR−A1AJ−01A−21D−A12Q−09 TCGA−AO−A12G−01A−11D−A10M−09 TCGA−A8−A09E−01A−11W−A019−09 TCGA−A8−A06O−01A−11W−A019−09 SA227 SA099 CGP_donor_1199105 CGP_donor_1163911 CGP_donor_1212364 TCGA−BH−A0W4−01A−11D−A10G−09 TCGA−A8−A094−01A−11W−A019−09 CSB25 CGP_donor_1230735 CGP_donor_1163910 BR−V−017 BR−V−016 BR−M−192 TCGA−EW−A1IY−01A−11D−A188−09 TCGA−E9−A22H−01A−11D−A159−09 TCGA−E2−A1L9−01A−11D−A13L−09 TCGA−E2−A15I−01A−21D−A135−09 TCGA−E2−A107−01A−11D−A10M−09 TCGA−D8−A1XU−01A−11D−A14K−09 TCGA−D8−A1X8−01A−11D−A14K−09 TCGA−D8−A141−01A−11D−A10Y−09 TCGA−C8−A26V−01A−11D−A16D−09 TCGA−BH−A0BS−01A−11D−A12Q−09 TCGA−BH−A0BR−01A−21W−A12T−09 TCGA−B6−A0WZ−01A−11D−A10G−09 TCGA−AR−A24X−01A−11D−A167−09 TCGA−AO−A12H−01A−11D−A10Y−09 TCGA−AN−A0XR−01A−11D−A10G−09 TCGA−A8−A099−01A−11W−A019−09 CGP_donor_1230734 BR−M−167 BR−M−155 BR−M−129 CGP_donor_1230733 TCGA−A8−A08L−01A−11W−A019−09 CSB1 CGP_donor_1212368 CGP_donor_1212361 BRC39 SA214 TCGA−E2−A1IN−01A−11D−A13L−09 TCGA−D8−A1Y1−01A−21D−A14K−09 TCGA−C8−A12T−01A−11D−A10Y−09 TCGA−BH−A0DL−01A−11D−A10Y−09 TCGA−AO−A0JA−01A−11W−A071−09 TCGA−AN−A03X−01A−21W−A019−09 TCGA−A8−A0A7−01A−11W−A019−09 TCGA−A2−A0YK−01A−22D−A117−09 TCGA−A2−A0EY−01A−11W−A050−09 BR−V−034 TCGA−E2−A15K−01A−11D−A12Q−09 TCGA−D8−A1JK−01A−11D−A13L−09 TCGA−D8−A1JJ−01A−31D−A14K−09 TCGA−C8−A26W−01A−11D−A16D−09 TCGA−C8−A131−01A−11D−A10Y−09 TCGA−BH−A203−01A−12D−A167−09 TCGA−BH−A0DE−01A−11D−A10Y−09 TCGA−BH−A0BT−01A−11D−A12Q−09 TCGA−BH−A0B0−01A−21D−A10Y−09 TCGA−AR−A1AS−01A−11D−A12Q−09 TCGA−AN−A0FS−01A−11W−A050−09 TCGA−AC−A23C−01A−12D−A167−09 TCGA−A7−A26H−01A−11D−A167−09 TCGA−A2−A0YT−01A−11D−A10G−09 TCGA−A2−A0D3−01A−11D−A10Y−09 TCGA−A2−A04P−01A−31D−A128−09 TCGA−A1−A0SI−01A−11D−A142−09 CGP_donor_1234112 CGP_donor_1212378 BRC18 BR−M−184 BR−M−050 TCGA−E9−A295−01A−11D−A16D−09 TCGA−E9−A1R4−01A−21D−A14G−09 TCGA−E9−A1NI−01A−11W−A16H−09 TCGA−E9−A1NG−01A−21D−A14K−09 TCGA−E9−A1N5−01A−11D−A14G−09 TCGA−E2−A1IO−01A−11D−A142−09 TCGA−E2−A1IF−01A−11D−A142−09 TCGA−E2−A1BD−01A−11D−A12Q−09 TCGA−E2−A15L−01A−11D−A12B−09 TCGA−E2−A15E−01A−11D−A12B−09 TCGA−E2−A105−01A−11D−A10M−09 TCGA−D8−A27P−01A−11D−A16D−09 TCGA−D8−A27L−01A−11D−A16D−09 TCGA−D8−A1Y2−01A−11D−A159−09 TCGA−D8−A1JP−01A−11D−A13L−09 TCGA−D8−A1JN−01A−11D−A13L−09 TCGA−D8−A1JE−01A−11D−A13L−09 TCGA−D8−A1JD−01A−11D−A13L−09 TCGA−D8−A146−01A−31D−A10Y−09 TCGA−D8−A143−01A−11D−A10Y−09 TCGA−C8−A274−01A−11D−A16D−09 TCGA−C8−A26X−01A−31D−A16D−09 TCGA−C8−A1HF−01A−11D−A135−09 TCGA−C8−A12U−01A−11D−A10Y−09 TCGA−C8−A12L−01A−11D−A10Y−09 TCGA−BH−A1F8−01A−11D−A13L−09 TCGA−BH−A1EY−01A−11D−A13L−09 TCGA−BH−A1EU−01A−11D−A135−09 TCGA−BH−A1ET−01A−11D−A135−09 TCGA−BH−A18M−01A−11D−A12B−09 TCGA−BH−A18I−01A−11D−A12B−09 TCGA−BH−A18F−01A−11D−A12B−09 TCGA−BH−A0EE−01A−11W−A050−09 TCGA−BH−A0EA−01A−11D−A10Y−09 TCGA−BH−A0DX−01A−11D−A10Y−09 TCGA−B6−A0X5−01A−21D−A10G−09 TCGA−B6−A0WW−01A−11D−A10G−09 TCGA−B6−A0RQ−01A−11D−A10Y−09 TCGA−B6−A0RN−01A−12D−A099−09 TCGA−B6−A0RG−01A−11W−A071−09 TCGA−AR−A1AW−01A−21D−A12Q−09 TCGA−AR−A1AL−01A−21D−A12Q−09 TCGA−AQ−A0Y5−01A−11D−A14K−09 TCGA−AO−A1KR−01A−12D−A142−09 TCGA−AO−A125−01A−11D−A10M−09 TCGA−AO−A0J5−01A−11W−A050−09 TCGA−AO−A03N−01B−11D−A10M−09 TCGA−AN−A0XO−01A−11D−A10G−09 TCGA−AN−A0AJ−01A−11W−A019−09 TCGA−A8−A0A1−01A−11W−A019−09 TCGA−A8−A095−01A−11W−A019−09 TCGA−A8−A093−01A−11W−A019−09 TCGA−A8−A092−01A−11W−A019−09 TCGA−A8−A08R−01A−11W−A050−09 TCGA−A8−A08P−01A−11W−A019−09 TCGA−A8−A08O−01A−21W−A071−09 TCGA−A8−A07G−01A−11W−A050−09 TCGA−A8−A07B−01A−11W−A019−09 TCGA−A8−A075−01A−11D−A099−09 TCGA−A8−A06U−01A−11W−A019−09 TCGA−A8−A06R−01A−11D−A015−09 TCGA−A8−A06Q−01A−11W−A050−09 TCGA−A2−A0YH−01A−11D−A10G−09 TCGA−A2−A0T4−01A−31D−A099−09 TCGA−A2−A0SY−01A−31D−A099−09 TCGA−A2−A0EO−01A−11W−A050−09 TCGA−A2−A0EM−01A−11W−A050−09 TCGA−A2−A0D1−01A−11W−A050−09 TCGA−A2−A04W−01A−31D−A10Y−09 TCGA−A2−A04V−01A−21W−A050−09 TCGA−A2−A04N−01A−11D−A10Y−09 CSB6 CSB30 CSB3 CSB17 CSB13 CGP_donor_1234117 CGP_donor_1212376 CGP_donor_1212360 CGP_donor_1187021 CGP_donor_1163904 BRC9 BRC50 BRC47 BRC33 BRC31 BRC3 BRC13 BR−V−064 BR−V−027 BR−V−021 BR−M−169 BR−M−120 TCGA−EW−A1PE−01A−11D−A142−09 TCGA−EW−A1P0−01A−11D−A142−09 TCGA−EW−A1OV−01A−11D−A142−09 TCGA−EW−A1J2−01A−21D−A13L−09 TCGA−EW−A1J1−01A−11D−A188−09 TCGA−EW−A1IX−01A−12D−A142−09 TCGA−EW−A1IW−01A−11D−A13L−09 TCGA−E9−A249−01A−11D−A167−09 TCGA−E9−A229−01A−31D−A17G−09 TCGA−E9−A227−01A−11D−A159−09 TCGA−E9−A226−01A−21D−A159−09 TCGA−E9−A1RI−01A−11D−A167−09 TCGA−E9−A1RE−01A−11D−A159−09 TCGA−E9−A1RD−01A−11D−A159−09 TCGA−E9−A1RC−01A−11D−A159−09 TCGA−E9−A1RA−01A−11D−A14G−09 TCGA−E9−A1R5−01A−11D−A14K−09 TCGA−E9−A1R3−01A−31D−A14K−09 TCGA−E9−A1R0−01A−22D−A16D−09 TCGA−E9−A1NH−01A−11D−A14G−09 TCGA−E2−A1L8−01A−11D−A13L−09 TCGA−E2−A1L6−01A−11D−A13L−09 TCGA−E2−A1IL−01A−11D−A14G−09 TCGA−E2−A1BC−01A−11D−A14G−09 TCGA−E2−A1B4−01A−11D−A12Q−09 TCGA−E2−A15P−01A−11D−A10Y−09 TCGA−E2−A15G−01A−11D−A12B−09 TCGA−E2−A15C−01A−31D−A12B−09 TCGA−E2−A156−01A−11D−A12B−09 TCGA−E2−A154−01A−11D−A10Y−09 TCGA−E2−A153−01A−12D−A12B−09 TCGA−E2−A14Y−01A−21D−A12B−09 TCGA−E2−A14V−01A−11D−A12B−09 TCGA−E2−A10F−01A−11D−A10M−09 TCGA−E2−A10B−01A−11D−A10M−09 TCGA−D8−A27T−01A−11D−A16D−09 TCGA−D8−A1XY−01A−11D−A14K−09 TCGA−D8−A1XS−01A−11D−A14K−09 TCGA−D8−A1XO−01A−11D−A14K−09 TCGA−D8−A1XM−01A−21D−A14K−09 TCGA−D8−A1XL−01A−11D−A14K−09 TCGA−D8−A1JU−01A−11D−A13L−09 TCGA−D8−A1JS−01A−11D−A13L−09 TCGA−D8−A1JH−01A−11D−A188−09 TCGA−D8−A1JF−01A−11D−A13L−09 TCGA−C8−A278−01A−11D−A167−09 TCGA−C8−A1HE−01A−11D−A188−09 TCGA−C8−A133−01A−32D−A12B−09 TCGA−C8−A130−01A−31D−A10Y−09 TCGA−C8−A12Y−01A−11D−A12B−09 TCGA−C8−A12N−01A−11D−A10Y−09 TCGA−BH−A208−01A−11D−A159−09 TCGA−BH−A202−01A−11D−A14K−09 TCGA−BH−A1FE−01A−11D−A13L−09 TCGA−BH−A18J−01A−11D−A12B−09 TCGA−BH−A18H−01A−11D−A12B−09 TCGA−BH−A0W7−01A−11D−A10Y−09 TCGA−BH−A0W5−01A−11D−A10G−09 TCGA−BH−A0W3−01A−11D−A10G−09 TCGA−BH−A0HN−01A−11D−A099−09 TCGA−BH−A0HI−01A−11D−A099−09 TCGA−BH−A0H9−01A−11W−A071−09 TCGA−BH−A0H3−01A−11D−A12Q−09 TCGA−BH−A0GY−01A−11W−A071−09 TCGA−BH−A0EB−01A−11W−A050−09 TCGA−BH−A0DV−01A−21D−A12Q−09 TCGA−BH−A0DT−01A−21D−A12B−09 TCGA−BH−A0DP−01A−21W−A071−09 TCGA−BH−A0DO−01B−11D−A12B−09 TCGA−BH−A0DK−01A−21W−A071−09 TCGA−BH−A0DD−01A−31D−A12Q−09 TCGA−BH−A0BV−01A−11W−A019−09 TCGA−BH−A0BO−01A−23D−A12B−09 TCGA−BH−A0BM−01A−11W−A071−09 TCGA−BH−A0BF−01A−21D−A12Q−09 TCGA−BH−A0BD−01A−11W−A050−09 TCGA−BH−A0BC−01A−22D−A099−09 TCGA−BH−A0BA−01A−11W−A071−09 TCGA−B6−A1KI−01A−11D−A14K−09 TCGA−B6−A0X7−01A−11D−A10M−09 TCGA−B6−A0WY−01A−11D−A10G−09 TCGA−B6−A0RP−01A−21D−A099−09 TCGA−B6−A0RO−01A−22D−A099−09 TCGA−B6−A0RH−01A−21D−A10Y−09 TCGA−B6−A0IP−01A−11D−A045−09 TCGA−B6−A0IK−01A−12W−A071−09 TCGA−B6−A0IE−01A−11W−A050−09 TCGA−B6−A0IC−01A−11W−A050−09 TCGA−B6−A0I5−01A−11W−A100−09 TCGA−AR−A255−01A−11D−A167−09 TCGA−AR−A24T−01A−11D−A167−09 TCGA−AR−A24S−01A−11D−A167−09 TCGA−AR−A24O−01A−11D−A167−09 TCGA−AR−A24M−01A−11D−A167−09 TCGA−AR−A24K−01A−11D−A167−09 TCGA−AR−A1AV−01A−21D−A12Q−09 TCGA−AR−A0TZ−01A−12D−A099−09 TCGA−AR−A0TR−01A−11D−A099−09 TCGA−AQ−A1H2−01A−11D−A13L−09 TCGA−AO−A12A−01A−21D−A10Y−09 TCGA−AO−A126−01A−11D−A10M−09 TCGA−AO−A0JF−01A−11W−A071−09 TCGA−AO−A0JE−01A−11W−A071−09 TCGA−AO−A0J7−01A−11W−A050−09 TCGA−AO−A03L−01A−41W−A071−09 TCGA−AN−A0XS−01A−22D−A10G−09 TCGA−AN−A0XP−01A−11D−A117−09 TCGA−AN−A0XL−01A−11D−A10M−09 TCGA−AN−A0FF−01A−11W−A050−09 TCGA−AN−A04C−01A−21W−A050−09 TCGA−AN−A049−01A−21W−A019−09 TCGA−AN−A03Y−01A−21W−A019−09 TCGA−AC−A23E−01A−11D−A159−09 TCGA−A8−A0A9−01A−11W−A019−09 TCGA−A8−A09D−01A−11W−A019−09 TCGA−A8−A09C−01A−11W−A019−09 TCGA−A8−A096−01A−11W−A019−09 TCGA−A8−A08Z−01A−21W−A019−09 TCGA−A8−A08T−01A−21W−A019−09 TCGA−A8−A08B−01A−11W−A019−09 TCGA−A8−A084−01A−21W−A019−09 TCGA−A8−A081−01A−11W−A019−09 TCGA−A8−A07Z−01A−11W−A019−09 TCGA−A8−A07E−01A−11W−A050−09 TCGA−A8−A06P−01A−11W−A019−09 TCGA−A7−A26E−01A−11D−A167−09 TCGA−A7−A13G−01A−11D−A13L−09 TCGA−A7−A0DB−01A−11W−A019−09 TCGA−A7−A0D9−01A−31W−A071−09 TCGA−A7−A0CJ−01A−21W−A019−09 TCGA−A7−A0CH−01A−21W−A019−09 TCGA−A7−A0CG−01A−11W−A019−09 TCGA−A2−A25C−01A−11D−A167−09 TCGA−A2−A25A−01A−12D−A16D−09 TCGA−A2−A1G0−01A−11D−A13L−09 TCGA−A2−A1FZ−01A−51D−A17G−09 TCGA−A2−A0YL−01A−21D−A10G−09 TCGA−A2−A0YI−01A−31D−A10M−09 TCGA−A2−A0YC−01A−11D−A117−09 TCGA−A2−A0T7−01A−21D−A099−09 TCGA−A2−A0EX−01A−21W−A050−09 TCGA−A2−A0EW−01A−21D−A10Y−09 TCGA−A2−A0EV−01A−11W−A050−09 TCGA−A2−A0EQ−01A−11W−A050−09 TCGA−A2−A0EN−01A−13D−A099−09 TCGA−A2−A0CW−01A−21D−A10Y−09 TCGA−A2−A0CS−01A−11D−A10Y−09 TCGA−A2−A0CP−01A−11W−A050−09 SA223 SA218 SA215 SA074 SA056 CSB27 CSB26 CSB24 CSB21 CSB15 CSB12 CGP_donor_1329917 CGP_donor_1310130 CGP_donor_1310129 CGP_donor_1230732 CGP_donor_1230726 CGP_donor_1212369 CGP_donor_1212367 CGP_donor_1212366 CGP_donor_1212365 CGP_donor_1212363 CGP_donor_1199132 CGP_donor_1199130 CGP_donor_1195184 CGP_donor_1186988 CGP_donor_1184344 CGP_donor_1184343 CGP_donor_1163909 CGP_donor_1163903 CGP_donor_1163900 CGP_donor_1163898 BRC8 BRC7 BRC52 BRC51 BRC5 BRC40 BRC4 BRC37 BRC36 BRC28 BRC24 BRC20 BRC15 BRC11 BRC10 BR−V−071 BR−V−052 BR−V−024 BR−V−020 BR−V−015 BR−V−003 BR−M−166 BR−M−165 BR−M−158 BR−M−150 BR−M−121 BR−M−116 BR−M−098 BR−M−083 BR−M−059 BR−M−055 BR−M−036 BR−M−030 BR−M−028 BR−M−026

unknown CG mut

FGA

PIK3CA AKT1 PTEN COL6A3 MYH8 ITPR1 MYH14 COL12A1 MYH11 MYO3A PLCG1 MYH1 MYH10 MYH4 VWF ADCY5 ITPR3 MYLK PRKCB COL14A1 MYH2 MYH7 MYH9 ROCK1 SOS1 ACTA2 COL6A2 JAK2 MYH6 PIK3CG PLCB3 PREX1 PRKCZ PTK2B VAV1 ACTB AKT3 CAMK2D COL20A1 CX3CR1 FPR3 GNAO1 GNB3 IKBKB INPPL1 ITPR2 MAPK1 MYH13 MYH3 MYLK2 NFATC4 PAK6 PLA2G4A PLCB1 PLCB4 XCR1 ACTBL2 ACTG1 ACTG2 ADCY2 ADCY6 AKT2 ALOX12 ALOX15 ARPC1A C5AR1 CASK CCL13 CCL4L2 CCR2 CHUK CX3CL1 CXCR3 GNAI2 GNAQ IFNAR1 IFNG ITGB1 MAPK3 NFATC2 NFKB2 NRAS PAK1 PAK2 PAK7 PIK3CB PIK3CD PLCB2 PLCG2 PRKACA PRKACG PRKCE PRKX PTGS1 RAF1 RHOA ACTA1 ARPC1B ARPC2 CAMK2A CCL11 CCL20 CCL3 CCL3L1 CCL5 CCR1 CCR3 CCR4 CCR7 CCRL2 COL6A1 CXCR1 FPR1 GNA14 GNAI1 GNAI3 GNG10 GNG4 GRK6 IL2 ITGAL ITGB7 JUN JUNB KRAS LTB4R2 MYLK3 NFAT5 NFATC3 PAK3 PAK4 PF4 PTGS2 RELA RELB RGS4 SHC1 SOCS4 SOCS5 SOCS6 STAT3

VWF

unknown CG mut TLN1

SPTA1 AKAP9 ERBB2 GRIN2A ERBB3 SPTB SPTAN1 ERBB4 ACTN2 EGFR PDGFRA FGFR2 GRIN2B KIT SOS1 SPTBN2 KL NCAM1 SPTBN1 GRIN2D JAK1 KLB PTPRA SPTBN4 SPTBN5 EGF FGF23 GRIN2C IL3RA JAK3 NRAS NRG1 PTK2 RASGRF1 RASGRF2 SHC3 ANGPT1 CAMK2D CSF2RB FGF3 FGF6 FGF9 GRB2 GRIN1 IL2RB IL2RG KITLG KRAS MAPK3 PDGFRB RAPGEF2 TEK CALM2 CSF2RA FGF10 FGF7 FGFR4 FRS3 FYN GFRA2 GFRA3 HRAS IL2 IL5RA JAK2 MAPK1 PDGFB RASGEF1A RASGRP1 RASGRP3 RASGRP4 RET BTC CALM3 CAMK2A CAMK2G DLG4 FGF1 FGF18 FGF8 GDNF HBEGF IRS1 LAT NRG3 SHC1 SHC2 unknown CG mut

COREAD

Collagen Degradation FDR = 0.054%, FDR nod = 0.028% Activation Of Matrix Metalloproteinases FDR = 0.003%, FDR nod = 0.0023%

TCGA−AG−A026−01 TCGA−AG−3581−01 TCGA−G4−6317−01 TCGA−AG−3887−01 TCGA−CK−4947−01 TCGA−AA−3520−01 TCGA−AY−5543−01 TCGA−AA−A01X−01 TCGA−F4−6703−01 TCGA−AF−3400−01 TCGA−AG−A02X−01 TCGA−AA−3555−01 TCGA−AA−A00R−01 TCGA−AA−3966−01 TCGA−CK−4948−01 TCGA−AH−6547−01 TCGA−D5−6539−01 TCGA−AG−A014−01 TCGA−G4−6323−01 TCGA−CM−6161−01 TCGA−AG−3883−01 TCGA−DY−A1DG−01 TCGA−DM−A1D6−01 TCGA−D5−6926−01 TCGA−CM−6171−01 TCGA−AA−3949−01 TCGA−A6−2676−01 TCGA−AA−3713−01 TCGA−AA−3664−01 TCGA−AA−3529−01 TCGA−AD−6889−01 TCGA−DM−A28G−01 TCGA−CM−6675−01 TCGA−AD−6901−01 TCGA−AA−A024−01 TCGA−D5−6535−01 TCGA−CM−4747−01 TCGA−AG−3882−01 TCGA−AF−2693−01 TCGA−AA−3666−01 TCGA−G4−6321−01 TCGA−G4−6310−01 TCGA−CM−5860−01 TCGA−AA−A02H−01 TCGA−AA−3869−01 TCGA−A6−6780−01 TCGA−CK−5913−01 TCGA−DY−A0XA−01 TCGA−CK−5914−01 TCGA−CA−5254−01 TCGA−AZ−5403−01 TCGA−A6−5664−01 TCGA−D5−6928−01 TCGA−CM−6172−01 TCGA−AA−3811−01 TCGA−F5−6813−01 TCGA−AG−A011−01 TCGA−AG−3885−01 TCGA−AG−3731−01 TCGA−EI−6507−01 TCGA−CK−5916−01 TCGA−AA−A022−01 TCGA−AA−3710−01 TCGA−G4−6309−01 TCGA−DM−A1D9−01 TCGA−AZ−4681−01 TCGA−AA−3697−01 TCGA−CM−4746−01 TCGA−AZ−6601−01 TCGA−AG−A02N−01 TCGA−AA−3715−01 TCGA−AA−3655−01 TCGA−A6−6654−01 TCGA−AG−3909−01 TCGA−AD−6899−01 TCGA−AA−3819−01 TCGA−AA−3818−01 TCGA−F4−6570−01 TCGA−A6−6653−01 TCGA−AA−A01R−01 TCGA−AA−3518−01 TCGA−DC−5337−01 TCGA−AA−3815−01 TCGA−AA−A00E−01 TCGA−AA−3956−01 TCGA−AA−3854−01 TCGA−A6−6648−01 TCGA−AA−3672−01 TCGA−AD−5900−01 TCGA−G4−6586−01 TCGA−EI−6506−01 TCGA−AD−6964−01 TCGA−G4−6626−01 TCGA−DM−A28E−01 TCGA−CM−6168−01 TCGA−AD−6548−01 TCGA−G4−6303−01 TCGA−D5−6929−01 TCGA−D5−6920−01 TCGA−AA−3680−01 TCGA−AA−3516−01 TCGA−CA−6718−01 TCGA−AD−6895−01 TCGA−DM−A0XD−01 TCGA−A6−3809−01 TCGA−D5−6537−01 TCGA−CA−6716−01 TCGA−AZ−6608−01 TCGA−AF−2691−01 TCGA−AA−A01P−01 TCGA−AA−3870−01 TCGA−AA−3543−01 TCGA−AA−3525−01 TCGA−A6−2672−01 TCGA−F4−6460−01 TCGA−DM−A1HA−01 TCGA−CM−6678−01 TCGA−CM−5864−01 TCGA−AG−3605−01 TCGA−AA−3980−01 TCGA−AA−3860−01 TCGA−AA−3542−01 TCGA−AG−A002−01 TCGA−AZ−4315−01 TCGA−AA−A010−01 TCGA−CA−6717−01 TCGA−G4−6588−01 TCGA−AA−3510−01 TCGA−CM−5861−01 TCGA−AZ−6598−01 TCGA−AA−A00N−01 TCGA−AA−3864−01 TCGA−AA−3663−01 TCGA−AA−3984−01 TCGA−AA−3977−01 TCGA−AA−3492−01 TCGA−A6−6781−01 TCGA−A6−5665−01 TCGA−CM−6674−01 TCGA−G4−6628−01 TCGA−D5−6540−01 TCGA−CM−6162−01 TCGA−AY−6197−01 TCGA−AA−3947−01 TCGA−D5−6930−01 TCGA−D5−6924−01 TCGA−CM−4743−01 TCGA−CK−6746−01 TCGA−AU−6004−01 TCGA−AG−A00H−01 TCGA−AG−3892−01 TCGA−AA−3950−01 TCGA−AA−3939−01 TCGA−AA−3845−01 TCGA−AA−3821−01 TCGA−A6−6782−01 TCGA−A6−6651−01 TCGA−A6−6141−01 TCGA−A6−2671−01 TCGA−F4−6807−01 TCGA−DY−A1DF−01 TCGA−DM−A1DA−01 TCGA−DC−6160−01 TCGA−D5−7000−01 TCGA−CM−6170−01 TCGA−CM−6163−01 TCGA−AZ−6603−01 TCGA−AZ−4323−01 TCGA−AG−3999−01 TCGA−AG−3890−01 TCGA−AG−3726−01 TCGA−AA−A03F−01 TCGA−AA−A02O−01 TCGA−AA−A01I−01 TCGA−AA−3994−01 TCGA−AA−3856−01 TCGA−AA−3848−01 TCGA−AA−3662−01 TCGA−A6−5661−01

TCGA−AG−A008−01 TCGA−DM−A1D8−01 TCGA−AA−3663−01 TCGA−AG−3598−01 TCGA−A6−6782−01 TCGA−DM−A1D4−01 TCGA−AA−3554−01 TCGA−F4−6703−01 TCGA−AF−3400−01 TCGA−CM−6166−01 TCGA−AZ−6607−01 TCGA−DC−5337−01 TCGA−AG−A026−01 TCGA−G4−6586−01 TCGA−EI−6506−01 TCGA−AA−3555−01 TCGA−AA−3542−01 TCGA−CM−6165−01 TCGA−AG−A025−01 TCGA−AF−6655−01 TCGA−AA−3867−01 TCGA−AA−3845−01 TCGA−AY−5543−01 TCGA−AG−A00H−01 TCGA−AA−A01X−01 TCGA−AA−A00R−01 TCGA−AA−3977−01 TCGA−AA−3966−01 TCGA−AA−A022−01 TCGA−CK−5916−01 TCGA−DM−A1D9−01 TCGA−D5−6540−01 TCGA−AZ−4681−01 TCGA−AA−3697−01 TCGA−CK−5913−01 TCGA−DY−A0XA−01 TCGA−CM−6168−01 TCGA−CK−5914−01 TCGA−CA−5254−01 TCGA−AZ−5403−01 TCGA−A6−5664−01 TCGA−D5−6928−01 TCGA−F5−6813−01 TCGA−CM−6172−01 TCGA−AG−A011−01 TCGA−AG−3885−01 TCGA−AG−3731−01 TCGA−AD−6895−01 TCGA−AD−5900−01 TCGA−AA−3950−01 TCGA−A6−2676−01 TCGA−DC−6682−01 TCGA−D5−6927−01 TCGA−CM−6171−01 TCGA−CM−4743−01 TCGA−AA−A00J−01 TCGA−AA−3525−01 TCGA−EI−6507−01 TCGA−AA−3864−01 TCGA−AA−3710−01 TCGA−A6−6780−01 TCGA−A6−3809−01 TCGA−G4−6323−01 TCGA−CM−6161−01 TCGA−AZ−6608−01 TCGA−AG−3883−01 TCGA−AA−3672−01 TCGA−A6−5665−01 TCGA−CM−4746−01 TCGA−AG−A02N−01 TCGA−AA−3655−01 TCGA−A6−6654−01 TCGA−AG−3909−01 TCGA−AA−3947−01 TCGA−AA−3819−01 TCGA−AA−3818−01 TCGA−A6−2672−01 TCGA−A6−2671−01 TCGA−AA−A01R−01 TCGA−AA−3492−01 TCGA−CM−5861−01 TCGA−AZ−6598−01 TCGA−F4−6570−01 TCGA−CM−6674−01 TCGA−AD−6964−01 TCGA−G4−6628−01 TCGA−D5−6535−01 TCGA−CM−6162−01 TCGA−CM−4747−01 TCGA−CA−6716−01 TCGA−AG−3882−01 TCGA−AF−2693−01 TCGA−AA−3815−01 TCGA−AA−3666−01 TCGA−CA−6717−01 TCGA−AA−3510−01 TCGA−AH−6644−01 TCGA−G4−6625−01 TCGA−F5−6464−01 TCGA−F4−6569−01 TCGA−DY−A1DF−01 TCGA−D5−6536−01 TCGA−D5−6529−01 TCGA−CM−6676−01 TCGA−CM−5860−01 TCGA−CI−6622−01 TCGA−CI−6619−01 TCGA−AF−4110−01 TCGA−AA−3979−01 TCGA−AA−3861−01 TCGA−AA−3713−01 TCGA−A6−5659−01 TCGA−AG−A002−01 TCGA−G4−6588−01 TCGA−AZ−4315−01 TCGA−AA−A010−01 TCGA−AZ−6601−01 TCGA−AA−A00N−01 TCGA−AA−3811−01 TCGA−AD−6889−01 TCGA−AA−3715−01 TCGA−A6−6141−01 TCGA−A6−5661−01 TCGA−G4−6309−01 TCGA−CM−5348−01 TCGA−CA−6718−01 TCGA−CA−6715−01 TCGA−AD−6899−01 TCGA−AA−3984−01 TCGA−A6−6781−01 TCGA−F4−6856−01 TCGA−DY−A1DG−01 TCGA−CM−5864−01 TCGA−CK−6746−01 TCGA−AG−4005−01 TCGA−AG−3605−01 TCGA−AA−3543−01 TCGA−AA−3516−01

EPHA2 Forward Signaling FDR = 1.9e−12%, FDR nod = 5.3e−06% E Cadherin Signaling In Keratinocytes FDR = 1.9e−12%, FDR nod = 2e−04%

TCGA−AA−3534−01 TCGA−AA−3543−01 TCGA−AA−A02K−01 TCGA−AA−A00R−01 TCGA−AA−A00K−01 TCGA−F4−6703−01 TCGA−AA−A022−01 TCGA−AA−3529−01 TCGA−AA−3516−01 TCGA−D5−6928−01 TCGA−A6−6653−01 TCGA−CK−5913−01 TCGA−AA−A01Q−01 TCGA−AA−3979−01 TCGA−AA−A01P−01 TCGA−AA−3972−01 TCGA−AA−3845−01 TCGA−DM−A1DA−01 TCGA−AA−3821−01 TCGA−AA−3966−01 TCGA−AA−3811−01 TCGA−D5−6924−01 TCGA−D5−5537−01 TCGA−AG−A026−01 TCGA−AD−6889−01 TCGA−D5−6533−01 TCGA−DM−A28K−01 TCGA−DM−A28E−01 TCGA−AZ−6600−01 TCGA−AA−3968−01 TCGA−AA−3518−01 TCGA−AA−A00A−01 TCGA−DC−6155−01 TCGA−CM−6679−01 TCGA−AG−3609−01 TCGA−AA−A01Z−01 TCGA−AA−3975−01 TCGA−AA−3693−01 TCGA−D5−6539−01 TCGA−AA−A01R−01 TCGA−AZ−6603−01 TCGA−AA−3672−01 TCGA−G4−6321−01 TCGA−CM−6677−01 TCGA−CM−5868−01 TCGA−AH−6547−01 TCGA−AG−A01Y−01 TCGA−AA−3949−01 TCGA−AA−3867−01 TCGA−A6−2672−01 TCGA−AG−A002−01 TCGA−A6−6781−01 TCGA−AA−3984−01 TCGA−G4−6626−01 TCGA−AG−3892−01 TCGA−G4−6309−01 TCGA−AD−6895−01 TCGA−EI−6508−01 TCGA−D5−6922−01 TCGA−CM−6167−01 TCGA−AH−6549−01 TCGA−AG−A025−01 TCGA−AG−3726−01 TCGA−AA−3833−01 TCGA−AA−3664−01 TCGA−AA−3552−01 TCGA−AA−A010−01 TCGA−G4−6588−01 TCGA−CM−4743−01 TCGA−CA−6717−01 TCGA−AZ−4315−01 TCGA−AA−3662−01 TCGA−G4−6628−01 TCGA−CM−5861−01 TCGA−CA−6718−01 TCGA−AZ−6601−01 TCGA−DM−A1DB−01 TCGA−CM−6171−01 TCGA−CM−5862−01 TCGA−CM−4752−01 TCGA−CM−4746−01 TCGA−CK−5916−01 TCGA−CK−4950−01 TCGA−CK−4947−01 TCGA−AZ−6598−01 TCGA−AZ−5407−01 TCGA−AY−5543−01 TCGA−AU−6004−01 TCGA−AG−A02N−01 TCGA−AA−A00N−01 TCGA−AA−3947−01 TCGA−A6−6780−01 TCGA−A6−5665−01 TCGA−G4−6625−01 TCGA−G4−6586−01 TCGA−G4−6310−01 TCGA−G4−6299−01 TCGA−EI−6507−01 TCGA−D5−6927−01 TCGA−D5−6540−01 TCGA−D5−6538−01 TCGA−D5−6536−01 TCGA−CM−6164−01 TCGA−CM−6161−01 TCGA−CM−5349−01 TCGA−CK−6746−01 TCGA−AZ−6608−01 TCGA−AD−5900−01 TCGA−AA−3815−01 TCGA−AA−3697−01 TCGA−AA−3663−01 TCGA−AA−3511−01 TCGA−AA−3510−01 TCGA−A6−6141−01 TCGA−A6−5661−01 TCGA−A6−5657−01 TCGA−G4−6315−01 TCGA−G4−6307−01 TCGA−G4−6304−01 TCGA−G4−6303−01 TCGA−F4−6807−01 TCGA−F4−6460−01 TCGA−EF−5830−01 TCGA−DY−A1DG−01 TCGA−DY−A0XA−01 TCGA−DT−5265−01 TCGA−DM−A28H−01 TCGA−DM−A1D9−01 TCGA−DM−A0XF−01 TCGA−DM−A0XD−01 TCGA−DM−A0X9−01 TCGA−DC−5869−01 TCGA−D5−6931−01 TCGA−D5−6923−01 TCGA−D5−6920−01 TCGA−D5−6541−01 TCGA−D5−6537−01 TCGA−D5−6532−01 TCGA−D5−5541−01 TCGA−D5−5539−01 TCGA−D5−5538−01 TCGA−CM−6678−01 TCGA−CM−6676−01 TCGA−CM−6674−01 TCGA−CM−6172−01 TCGA−CM−6162−01 TCGA−CK−6747−01 TCGA−CK−5914−01 TCGA−CK−4952−01 TCGA−CK−4948−01 TCGA−CA−6719−01 TCGA−AZ−6599−01 TCGA−AY−6386−01 TCGA−AY−6197−01 TCGA−AU−3779−01 TCGA−AG−3742−01 TCGA−AF−6136−01 TCGA−AF−2687−01 TCGA−AD−6964−01 TCGA−AD−6963−01 TCGA−AD−6899−01 TCGA−AA−3977−01 TCGA−AA−3877−01 TCGA−AA−3864−01 TCGA−AA−3715−01 TCGA−AA−3713−01 TCGA−AA−3712−01 TCGA−AA−3492−01 TCGA−A6−5662−01 TCGA−A6−5660−01 TCGA−A6−5656−01 TCGA−G5−6235−01 TCGA−G4−6323−01 TCGA−G4−6317−01 TCGA−G4−6293−01 TCGA−F5−6813−01 TCGA−F5−6811−01 TCGA−F5−6571−01 TCGA−F4−6856−01 TCGA−F4−6855−01 TCGA−F4−6854−01 TCGA−F4−6809−01 TCGA−F4−6808−01 TCGA−F4−6805−01 TCGA−F4−6570−01 TCGA−F4−6569−01 TCGA−F4−6459−01 TCGA−DY−A1DC−01 TCGA−DM−A28G−01 TCGA−DM−A28C−01 TCGA−DM−A285−01 TCGA−DM−A1HA−01 TCGA−DM−A1D8−01 TCGA−DM−A1D7−01 TCGA−DC−6683−01 TCGA−DC−6682−01 TCGA−DC−6160−01 TCGA−DC−6158−01 TCGA−DC−6157−01 TCGA−D5−7000−01 TCGA−D5−6929−01 TCGA−D5−6926−01 TCGA−D5−6898−01 TCGA−D5−6534−01 TCGA−D5−6529−01 TCGA−D5−5540−01 TCGA−CM−6680−01 TCGA−CM−6169−01 TCGA−CM−6168−01 TCGA−CM−6166−01 TCGA−CM−5864−01 TCGA−CM−5860−01 TCGA−CM−5344−01 TCGA−CM−4747−01 TCGA−CL−5918−01 TCGA−CL−5917−01 TCGA−CK−5912−01 TCGA−CI−6624−01 TCGA−CI−6622−01 TCGA−CI−6619−01 TCGA−AZ−6606−01 TCGA−AZ−5403−01 TCGA−AZ−4682−01 TCGA−AZ−4616−01 TCGA−AH−6644−01 TCGA−AH−6643−01 TCGA−AH−6544−01 TCGA−AG−A020−01 TCGA−AG−A00H−01 TCGA−AG−4015−01 TCGA−AG−3901−01 TCGA−AG−3887−01 TCGA−AG−3878−01 TCGA−AG−3731−01 TCGA−AF−6672−01 TCGA−AF−2693−01 TCGA−AD−6965−01 TCGA−AD−6890−01 TCGA−AD−6548−01 TCGA−AA−A03J−01 TCGA−AA−A03F−01 TCGA−AA−A02Y−01 TCGA−AA−A02O−01 TCGA−AA−A01V−01 TCGA−AA−A01K−01 TCGA−AA−A01I−01 TCGA−AA−3956−01 TCGA−AA−3950−01 TCGA−AA−3939−01 TCGA−AA−3866−01 TCGA−AA−3852−01 TCGA−AA−3850−01 TCGA−AA−3848−01 TCGA−AA−3837−01 TCGA−AA−3818−01 TCGA−AA−3812−01 TCGA−AA−3696−01 TCGA−AA−3673−01 TCGA−AA−3660−01 TCGA−AA−3655−01 TCGA−AA−3496−01 TCGA−AA−3489−01 TCGA−A6−6782−01 TCGA−A6−6654−01 TCGA−A6−6652−01 TCGA−A6−6649−01 TCGA−A6−5666−01 TCGA−A6−5659−01 TCGA−A6−4105−01 TCGA−A6−3809−01 TCGA−A6−3808−01

TCGA−CK−5913−01 TCGA−AA−3710−01 TCGA−AA−A00K−01 TCGA−AA−A022−01 TCGA−AA−3692−01 TCGA−AA−3672−01 TCGA−AA−A02J−01 TCGA−AA−3684−01 TCGA−D5−5537−01 TCGA−AA−3516−01 TCGA−AA−3972−01 TCGA−CI−6621−01 TCGA−AA−A01Q−01 TCGA−AA−3845−01 TCGA−AG−3608−01 TCGA−AA−A01F−01 TCGA−AA−3861−01 TCGA−AA−3520−01 TCGA−AA−A01P−01 TCGA−A6−6653−01 TCGA−CM−5341−01 TCGA−AF−4110−01 TCGA−AA−3994−01 TCGA−A6−2671−01 TCGA−AA−3984−01 TCGA−A6−6781−01 TCGA−AD−6895−01 TCGA−G4−6309−01 TCGA−EI−6508−01 TCGA−D5−6922−01 TCGA−CM−6167−01 TCGA−AH−6549−01 TCGA−AG−A025−01 TCGA−AG−3726−01 TCGA−AA−3833−01 TCGA−AA−3664−01 TCGA−AA−3552−01 TCGA−AG−A002−01 TCGA−AA−3966−01 TCGA−AA−A00R−01 TCGA−AA−A00E−01 TCGA−AA−3968−01 TCGA−AA−3542−01 TCGA−DY−A1DD−01 TCGA−CM−6677−01 TCGA−CK−6751−01 TCGA−CK−6748−01 TCGA−AZ−6603−01 TCGA−AY−6196−01 TCGA−AA−3982−01 TCGA−AA−3811−01 TCGA−AA−3518−01 TCGA−G4−6626−01 TCGA−DY−A1DF−01 TCGA−D5−6533−01 TCGA−AZ−6605−01 TCGA−AD−6901−01 TCGA−F4−6703−01 TCGA−EI−6510−01 TCGA−DM−A1D6−01 TCGA−CM−6675−01 TCGA−CM−6163−01 TCGA−CM−4744−01 TCGA−AH−6547−01 TCGA−AG−3881−01 TCGA−AG−3575−01 TCGA−AF−6655−01 TCGA−AA−3831−01 TCGA−AA−3534−01 TCGA−A6−2678−01 TCGA−AA−A01R−01 TCGA−AG−3892−01 TCGA−AD−6889−01 TCGA−F5−6465−01 TCGA−D5−6930−01 TCGA−D5−6928−01 TCGA−D5−6539−01 TCGA−CK−5915−01 TCGA−G4−6306−01 TCGA−DM−A28F−01 TCGA−DM−A1D4−01 TCGA−DC−5337−01 TCGA−D5−6535−01 TCGA−CM−6170−01 TCGA−AZ−6600−01 TCGA−AG−3732−01 TCGA−AA−A02K−01 TCGA−AA−A00U−01 TCGA−AA−3821−01 TCGA−AA−3502−01 TCGA−G4−6321−01 TCGA−DM−A28E−01 TCGA−DM−A282−01 TCGA−D5−6932−01 TCGA−CM−6679−01 TCGA−CM−5868−01 TCGA−CM−5348−01 TCGA−CA−6715−01 TCGA−CA−5797−01 TCGA−A6−6648−01 TCGA−AZ−6598−01 TCGA−AZ−4315−01 TCGA−CA−6717−01 TCGA−CM−6171−01 TCGA−AD−6964−01 TCGA−AA−A010−01 TCGA−AA−A00N−01 TCGA−AA−3713−01 TCGA−AA−3663−01 TCGA−A6−6780−01 TCGA−G4−6588−01 TCGA−F4−6856−01 TCGA−F4−6570−01 TCGA−EI−6507−01 TCGA−DY−A1DG−01 TCGA−D5−6536−01 TCGA−CK−5916−01 TCGA−CK−4950−01 TCGA−AU−6004−01 TCGA−AU−3779−01 TCGA−AA−3697−01 TCGA−A6−5661−01 TCGA−G4−6586−01 TCGA−G4−6323−01 TCGA−G4−6315−01 TCGA−G4−6310−01 TCGA−G4−6307−01 TCGA−G4−6304−01 TCGA−F4−6460−01 TCGA−DM−A1DB−01 TCGA−D5−6537−01 TCGA−CM−6168−01 TCGA−CM−6166−01 TCGA−CM−6162−01 TCGA−CM−5344−01 TCGA−CM−4752−01 TCGA−CM−4743−01 TCGA−CK−5914−01 TCGA−CK−4952−01 TCGA−AZ−6601−01 TCGA−AZ−6599−01 TCGA−AA−3977−01 TCGA−AA−3864−01 TCGA−AA−3712−01 TCGA−AA−3662−01 TCGA−A6−6141−01 TCGA−A6−5665−01 TCGA−A6−5660−01 TCGA−A6−3809−01 TCGA−G4−6628−01 TCGA−G4−6317−01 TCGA−G4−6303−01 TCGA−F5−6811−01 TCGA−EF−5830−01 TCGA−DY−A0XA−01 TCGA−DM−A1D7−01 TCGA−D5−6898−01 TCGA−D5−6540−01 TCGA−D5−6538−01 TCGA−D5−5540−01 TCGA−CM−6678−01 TCGA−CM−6172−01 TCGA−CM−6164−01 TCGA−CM−6161−01 TCGA−CM−5864−01 TCGA−CM−5862−01 TCGA−CM−5860−01 TCGA−CM−5349−01 TCGA−CK−6746−01 TCGA−CA−6718−01 TCGA−AZ−6608−01 TCGA−AZ−5407−01 TCGA−AY−6386−01 TCGA−AY−6197−01 TCGA−AY−5543−01 TCGA−AF−2687−01 TCGA−AD−5900−01 TCGA−AA−3947−01 TCGA−AA−3815−01 TCGA−AA−3715−01 TCGA−AA−3655−01 TCGA−AA−3510−01 TCGA−A6−5662−01 TCGA−A6−5657−01 TCGA−G5−6235−01 TCGA−G4−6625−01 TCGA−G4−6299−01 TCGA−G4−6293−01 TCGA−F5−6813−01 TCGA−F5−6571−01 TCGA−F4−6855−01 TCGA−F4−6854−01 TCGA−F4−6809−01 TCGA−F4−6808−01 TCGA−F4−6805−01 TCGA−F4−6569−01 TCGA−F4−6459−01 TCGA−DM−A285−01 TCGA−DM−A1HA−01 TCGA−DM−A1D9−01 TCGA−DM−A1D8−01 TCGA−DM−A0XF−01 TCGA−DM−A0XD−01 TCGA−DM−A0X9−01 TCGA−DC−6682−01 TCGA−D5−6927−01 TCGA−D5−6920−01 TCGA−D5−6541−01 TCGA−D5−6534−01 TCGA−D5−6532−01 TCGA−D5−6529−01 TCGA−D5−5541−01 TCGA−D5−5539−01 TCGA−CM−6680−01 TCGA−CM−6676−01 TCGA−CM−6674−01 TCGA−CM−6169−01 TCGA−CM−4747−01 TCGA−CL−5917−01 TCGA−CK−6747−01 TCGA−CK−5912−01 TCGA−CK−4948−01 TCGA−AZ−5403−01 TCGA−AZ−4616−01 TCGA−AH−6643−01 TCGA−AH−6544−01 TCGA−AG−A020−01 TCGA−AG−3742−01 TCGA−AG−3731−01 TCGA−AF−6136−01 TCGA−AF−2693−01 TCGA−AD−6899−01 TCGA−AA−A01K−01 TCGA−AA−3696−01 TCGA−AA−3660−01 TCGA−AA−3511−01 TCGA−AA−3496−01 TCGA−AA−3492−01 TCGA−A6−5666−01 TCGA−A6−5659−01 TCGA−A6−5656−01 TCGA−F4−6807−01 TCGA−DY−A1DC−01 TCGA−DT−5265−01 TCGA−DM−A28H−01 TCGA−DM−A28G−01 TCGA−DM−A28C−01 TCGA−DC−6683−01 TCGA−DC−6160−01 TCGA−DC−6158−01 TCGA−DC−6157−01 TCGA−DC−5869−01 TCGA−D5−7000−01 TCGA−D5−6931−01 TCGA−D5−6929−01 TCGA−D5−6926−01 TCGA−D5−6923−01 TCGA−D5−5538−01 TCGA−CM−5861−01 TCGA−CM−4746−01 TCGA−CL−5918−01 TCGA−CK−4947−01 TCGA−CI−6624−01 TCGA−CI−6622−01 TCGA−CI−6619−01 TCGA−CA−6719−01 TCGA−AZ−6606−01 TCGA−AZ−4682−01 TCGA−AH−6644−01 TCGA−AG−A02N−01 TCGA−AG−A00H−01 TCGA−AG−4015−01 TCGA−AG−3901−01 TCGA−AG−3887−01 TCGA−AG−3878−01 TCGA−AF−6672−01 TCGA−AD−6965−01 TCGA−AD−6963−01 TCGA−AD−6890−01 TCGA−AD−6548−01 TCGA−AA−A03J−01 TCGA−AA−A03F−01 TCGA−AA−A02Y−01 TCGA−AA−A02O−01 TCGA−AA−A01V−01 TCGA−AA−A01I−01 TCGA−AA−3956−01 TCGA−AA−3950−01 TCGA−AA−3939−01 TCGA−AA−3877−01 TCGA−AA−3866−01 TCGA−AA−3852−01 TCGA−AA−3850−01 TCGA−AA−3848−01 TCGA−AA−3837−01 TCGA−AA−3818−01 TCGA−AA−3812−01 TCGA−AA−3673−01 TCGA−AA−3489−01 TCGA−A6−6782−01 TCGA−A6−6654−01 TCGA−A6−6652−01 TCGA−A6−6649−01 TCGA−A6−4105−01 TCGA−A6−3808−01

PDGF Pathway FDR = 8.9e−10%, FDR nod = 0.0023% Ephrin B Reverse Signaling FDR = 1.9e−12%, FDR nod = 5.3e−06%

wt wt

VAV2 FYN

known HCG mut known HCG mut EPHB1

COL19A1 MMP19

COL18A1

MMP2 KLKB1

MMP8

COL16A1

MMP2

MMP14

COL15A1 MMP7

COL25A1 FURIN

PRSS1

COL9A2

CTSV

COL17A1

KLK2

CTSL MMP10

MMP14 MMP11

MMP3

MMP7

MMP17

ADAM17 MMP3

MMP20

TIMP2

ADAM9 CMA1

COL13A1 CTSG

CTSB

ADAM10

ELANE

MMP24

COL23A1

COL26A1 CTRB1

COL9A3 CTRB2

ELANE MMP1

MMP1

MMP10

MMP25

CTSD

TIMP1

MMP11 TPSAB1

PHYKPL

unknown CG mut unknown CG mut PIK3CA

PIK3CA CDH1

PIK3R1

TIAM1 EGFR

EPHA2 PLCG1

RHOA AKT1

CASR

SHC1 PIP5K1A

ACP1 JUP

PAK1 SRC

SRC VASP

INPPL1

BCAR1 FMN1

PTK2 RAC1

RHOA

RAC1 ZYX

VAV2

unknown CG mut unknown CG mut

PIK3R1 PIK3CA

TIAM1 PIK3R1

CHUK TIAM1

VAV1 DNM1

PTPN13

RAF1

RGS3

EPHB2

RHOA

MAP3K7

YES1

EPHB4

SRC

FGR

PAK1

ITGB3

STAT1

LCK

MAPK8

STAT3

BLK

WASL

EFNB1

EFNB2

ARFIP2

ITGA2B

LYN

CDC42

NCK2

RAC1

RAC1

SRC

known HCG mut VAV3 CTNNB1

known HCG mut

wt COL18A1

known HCG mut MMP9

wt ARHGAP35 wt FYN

COL9A1 MMP15

wt MMP8

MMP15 FURIN

known HCG mut MMP9

COL14A1 MMP16

unknown CG mut COL12A1 PLG

unknown CG mut

PIK3R1

CTNNA1

CBL

AJUBA

AKT2

CTNND1

EFNA1 GRB2

MAP2K4

HCK

TCGA−DM−A0X9−01 TCGA−AA−3966−01 TCGA−CK−6746−01 TCGA−A6−6653−01 TCGA−F4−6570−01 TCGA−DM−A1HA−01 TCGA−AD−5900−01 TCGA−AA−3514−01 TCGA−DC−6158−01 TCGA−D5−6928−01 TCGA−AZ−5403−01 TCGA−AA−3715−01 TCGA−AD−6899−01 TCGA−AA−A00R−01 TCGA−AA−A00K−01 TCGA−AA−3815−01 TCGA−F4−6703−01 TCGA−D5−6539−01 TCGA−AD−6963−01 TCGA−AA−A022−01 TCGA−G4−6310−01 TCGA−CM−6678−01 TCGA−CK−4948−01 TCGA−AA−A01P−01 TCGA−AA−3972−01 TCGA−AA−3845−01 TCGA−DM−A28H−01 TCGA−CM−6162−01 TCGA−CM−4746−01 TCGA−AA−A01V−01 TCGA−AA−3562−01 TCGA−AA−3516−01 TCGA−D5−6536−01 TCGA−AA−3663−01 TCGA−G4−6625−01 TCGA−G4−6586−01 TCGA−D5−6541−01 TCGA−D5−6537−01 TCGA−D5−6533−01 TCGA−CM−5861−01 TCGA−CK−4947−01 TCGA−AA−3534−01 TCGA−AA−A01R−01 TCGA−A6−5661−01 TCGA−G4−6303−01 TCGA−D5−6535−01 TCGA−CM−5348−01 TCGA−AY−6386−01 TCGA−AA−A02O−01 TCGA−AA−A01G−01 TCGA−AA−3950−01 TCGA−AA−3821−01 TCGA−AA−3672−01 TCGA−AA−3531−01 TCGA−AA−3525−01 TCGA−AA−3510−01 TCGA−CA−6718−01 TCGA−F4−6856−01 TCGA−CI−6624−01 TCGA−AZ−5407−01 TCGA−AA−A02K−01 TCGA−AA−3555−01 TCGA−G4−6304−01 TCGA−DM−A1D8−01 TCGA−DC−6681−01 TCGA−D5−6534−01 TCGA−CM−6677−01 TCGA−CA−6719−01 TCGA−AZ−6607−01 TCGA−A6−5659−01 TCGA−CM−4743−01 TCGA−G4−6628−01 TCGA−G4−6588−01 TCGA−AZ−6598−01 TCGA−AA−A00N−01 TCGA−AA−3977−01 TCGA−AA−3947−01 TCGA−AA−3864−01 TCGA−CM−5349−01 TCGA−AG−A02N−01 TCGA−AA−A00A−01 TCGA−A6−6141−01 TCGA−DT−5265−01 TCGA−DC−6155−01 TCGA−DC−5869−01 TCGA−D5−6540−01 TCGA−D5−6538−01 TCGA−CM−6679−01 TCGA−AZ−6601−01 TCGA−AG−3609−01 TCGA−AA−A01Z−01 TCGA−AA−3975−01 TCGA−AA−3693−01 TCGA−AA−3492−01 TCGA−A6−5657−01 TCGA−AG−A002−01 TCGA−AA−A010−01 TCGA−CA−6717−01 TCGA−AZ−4315−01 TCGA−CK−5916−01 TCGA−A6−6781−01 TCGA−G4−6626−01 TCGA−CM−6161−01 TCGA−CK−4950−01 TCGA−AG−3892−01 TCGA−AA−3984−01 TCGA−AA−3662−01 TCGA−D5−6532−01 TCGA−CM−6674−01 TCGA−CM−6171−01 TCGA−CM−5862−01 TCGA−AU−6004−01 TCGA−AU−3779−01 TCGA−AD−6895−01 TCGA−AA−3697−01 TCGA−G4−6315−01 TCGA−G4−6309−01 TCGA−G4−6307−01 TCGA−F4−6460−01 TCGA−EI−6508−01 TCGA−EI−6507−01 TCGA−DY−A1DG−01 TCGA−DM−A1DB−01 TCGA−DM−A1D9−01 TCGA−DM−A0XD−01 TCGA−D5−6927−01 TCGA−D5−6922−01 TCGA−D5−5541−01 TCGA−CM−6167−01 TCGA−CM−6164−01 TCGA−CM−4752−01 TCGA−CK−5914−01 TCGA−AZ−6608−01 TCGA−AY−5543−01 TCGA−AH−6549−01 TCGA−AG−A025−01 TCGA−AG−3726−01 TCGA−AA−3833−01 TCGA−AA−3664−01 TCGA−AA−3552−01 TCGA−AA−3511−01 TCGA−A6−6780−01 TCGA−A6−5665−01 TCGA−A6−5660−01 TCGA−A6−5656−01

TCGA−AA−A00K−01 TCGA−AZ−4323−01 TCGA−F4−6703−01 TCGA−AF−5654−01 TCGA−AA−3855−01 TCGA−AA−A00E−01 TCGA−D5−6928−01 TCGA−AA−3819−01 TCGA−CK−5913−01 TCGA−AA−3710−01 TCGA−AA−A01Q−01 TCGA−AG−3601−01 TCGA−AA−3681−01 TCGA−AA−A00R−01 TCGA−DM−A28E−01 TCGA−CK−6751−01 TCGA−AA−3821−01 TCGA−EI−6506−01 TCGA−D5−6930−01 TCGA−AA−A02H−01 TCGA−AA−3955−01 TCGA−CM−5341−01 TCGA−AF−4110−01 TCGA−AA−3994−01 TCGA−A6−2671−01 TCGA−A6−2676−01 TCGA−AD−6889−01 TCGA−AG−3599−01 TCGA−A6−6138−01 TCGA−AA−3949−01 TCGA−DM−A1D6−01 TCGA−DM−A1D4−01 TCGA−D5−6932−01 TCGA−D5−6924−01 TCGA−DC−6155−01 TCGA−CM−6679−01 TCGA−AG−3609−01 TCGA−AA−A01Z−01 TCGA−AA−A00A−01 TCGA−AA−3975−01 TCGA−AA−3693−01 TCGA−AA−A01P−01 TCGA−A6−6653−01 TCGA−DC−6681−01 TCGA−D5−6533−01 TCGA−CM−5348−01 TCGA−AZ−6607−01 TCGA−AZ−6600−01 TCGA−AA−A01R−01 TCGA−AA−3695−01 TCGA−AA−3685−01 TCGA−AA−3680−01 TCGA−AG−A002−01 TCGA−AA−3984−01 TCGA−AG−3892−01 TCGA−AD−6895−01 TCGA−A6−6781−01 TCGA−G4−6626−01 TCGA−G4−6309−01 TCGA−EI−6508−01 TCGA−D5−6922−01 TCGA−CM−6167−01 TCGA−AH−6549−01 TCGA−AG−A025−01 TCGA−AG−3726−01 TCGA−AA−3833−01 TCGA−AA−3664−01 TCGA−AA−3552−01 TCGA−AA−3672−01 TCGA−F5−6812−01 TCGA−AY−6196−01 TCGA−AD−6901−01 TCGA−AA−3845−01 TCGA−DM−A1DA−01 TCGA−DC−5337−01 TCGA−D5−6539−01 TCGA−D5−6535−01 TCGA−CA−6716−01 TCGA−AG−A00Y−01 TCGA−AG−3727−01 TCGA−AA−3986−01 TCGA−AA−3966−01 TCGA−AA−3952−01 TCGA−AA−3861−01 TCGA−AA−3814−01 TCGA−AA−A010−01 TCGA−AA−3864−01 TCGA−G4−6628−01 TCGA−CK−5916−01 TCGA−AZ−6601−01 TCGA−CM−6171−01 TCGA−CA−6717−01 TCGA−AZ−4315−01 TCGA−AG−A02N−01 TCGA−AA−3947−01 TCGA−A6−6141−01 TCGA−CM−6162−01 TCGA−CM−5349−01 TCGA−CA−6718−01 TCGA−AU−3779−01 TCGA−AA−A00N−01 TCGA−AA−3977−01 TCGA−AA−3713−01 TCGA−AA−3697−01 TCGA−AA−3662−01 TCGA−A6−5665−01 TCGA−G4−6588−01 TCGA−G4−6293−01 TCGA−DM−A0X9−01 TCGA−D5−6540−01 TCGA−D5−6532−01 TCGA−CM−6161−01 TCGA−CM−4743−01 TCGA−CK−4950−01 TCGA−AZ−6599−01 TCGA−AZ−6598−01 TCGA−AU−6004−01 TCGA−AA−3815−01 TCGA−AA−3492−01 TCGA−A6−6780−01 TCGA−G4−6323−01 TCGA−G4−6317−01 TCGA−G4−6307−01 TCGA−F4−6856−01 TCGA−EI−6507−01 TCGA−DY−A1DG−01 TCGA−DM−A1DB−01 TCGA−DM−A1D9−01 TCGA−DM−A0XD−01 TCGA−DC−6157−01 TCGA−D5−6929−01 TCGA−D5−6538−01 TCGA−CM−6674−01 TCGA−CL−5918−01 TCGA−CK−6746−01 TCGA−AZ−6608−01 TCGA−AY−6386−01 TCGA−AY−6197−01 TCGA−AY−5543−01 TCGA−AF−6672−01 TCGA−AD−6899−01 TCGA−AD−5900−01 TCGA−AA−3950−01 TCGA−AA−3877−01 TCGA−AA−3715−01 TCGA−AA−3663−01 TCGA−AA−3510−01 TCGA−A6−5666−01 TCGA−A6−5661−01 TCGA−A6−5660−01 TCGA−A6−5657−01 TCGA−G4−6625−01 TCGA−G4−6586−01 TCGA−G4−6315−01 TCGA−G4−6310−01 TCGA−G4−6303−01 TCGA−F5−6813−01 TCGA−F5−6571−01 TCGA−F4−6809−01 TCGA−F4−6808−01 TCGA−F4−6807−01 TCGA−F4−6570−01 TCGA−F4−6569−01 TCGA−F4−6460−01 TCGA−DT−5265−01 TCGA−DM−A1D7−01 TCGA−DC−6160−01 TCGA−DC−5869−01 TCGA−D5−7000−01 TCGA−D5−6931−01 TCGA−D5−6927−01 TCGA−D5−6920−01 TCGA−D5−6536−01 TCGA−D5−5541−01 TCGA−D5−5540−01 TCGA−D5−5539−01 TCGA−D5−5538−01 TCGA−CM−6680−01 TCGA−CM−6678−01 TCGA−CM−6172−01 TCGA−CM−6166−01 TCGA−CM−6164−01 TCGA−CM−5862−01 TCGA−CM−5861−01 TCGA−CM−4752−01 TCGA−CM−4746−01 TCGA−CK−5914−01 TCGA−CK−4952−01 TCGA−CK−4948−01 TCGA−CK−4947−01 TCGA−AD−6964−01 TCGA−AD−6548−01 TCGA−AA−3956−01 TCGA−AA−3511−01 TCGA−A6−5656−01 TCGA−A6−4105−01 TCGA−G5−6235−01 TCGA−G4−6304−01 TCGA−G4−6299−01 TCGA−F5−6811−01 TCGA−F4−6855−01 TCGA−F4−6854−01 TCGA−F4−6805−01 TCGA−F4−6459−01 TCGA−EF−5830−01 TCGA−DY−A1DC−01 TCGA−DY−A0XA−01 TCGA−DM−A28H−01 TCGA−DM−A28G−01 TCGA−DM−A28C−01 TCGA−DM−A285−01 TCGA−DM−A1HA−01 TCGA−DM−A1D8−01 TCGA−DM−A0XF−01 TCGA−DC−6683−01 TCGA−DC−6682−01 TCGA−DC−6158−01 TCGA−D5−6926−01 TCGA−D5−6923−01 TCGA−D5−6898−01 TCGA−D5−6541−01 TCGA−D5−6537−01 TCGA−D5−6534−01 TCGA−D5−6529−01 TCGA−CM−6676−01 TCGA−CM−6169−01 TCGA−CM−6168−01 TCGA−CM−5864−01 TCGA−CM−5860−01 TCGA−CM−5344−01 TCGA−CM−4747−01 TCGA−CL−5917−01 TCGA−CK−6747−01 TCGA−CK−5912−01 TCGA−CI−6624−01 TCGA−CI−6622−01 TCGA−CI−6619−01 TCGA−CA−6719−01 TCGA−AZ−6606−01 TCGA−AZ−5407−01 TCGA−AZ−5403−01 TCGA−AZ−4682−01 TCGA−AZ−4616−01 TCGA−AH−6644−01 TCGA−AH−6643−01 TCGA−AH−6544−01 TCGA−AG−A020−01 TCGA−AG−A00H−01 TCGA−AG−4015−01 TCGA−AG−3901−01 TCGA−AG−3887−01 TCGA−AG−3878−01 TCGA−AG−3742−01 TCGA−AG−3731−01 TCGA−AF−6136−01 TCGA−AF−2693−01 TCGA−AF−2687−01 TCGA−AD−6965−01 TCGA−AD−6963−01 TCGA−AD−6890−01 TCGA−AA−A03J−01 TCGA−AA−A03F−01 TCGA−AA−A02Y−01 TCGA−AA−A02O−01 TCGA−AA−A01V−01 TCGA−AA−A01K−01 TCGA−AA−A01I−01 TCGA−AA−3939−01 TCGA−AA−3866−01 TCGA−AA−3852−01 TCGA−AA−3850−01 TCGA−AA−3848−01 TCGA−AA−3837−01 TCGA−AA−3818−01 TCGA−AA−3812−01 TCGA−AA−3712−01 TCGA−AA−3696−01 TCGA−AA−3673−01 TCGA−AA−3660−01 TCGA−AA−3655−01 TCGA−AA−3496−01 TCGA−AA−3489−01 TCGA−A6−6782−01 TCGA−A6−6654−01 TCGA−A6−6652−01 TCGA−A6−6649−01 TCGA−A6−5662−01 TCGA−A6−5659−01 TCGA−A6−3809−01 TCGA−A6−3808−01

TCGA−AA−3538−01 TCGA−AZ−6601−01 TCGA−G5−6235−01 TCGA−AZ−6600−01 TCGA−AA−3949−01 TCGA−G4−6625−01 TCGA−G4−6304−01 TCGA−AA−3818−01 TCGA−AA−A02J−01 TCGA−AA−3655−01 TCGA−AZ−6608−01 TCGA−AD−6548−01 TCGA−AA−A022−01 TCGA−AA−3663−01 TCGA−A6−6780−01 TCGA−AA−3516−01 TCGA−AA−3489−01 TCGA−A6−2671−01 TCGA−AG−3892−01 TCGA−AD−6889−01 TCGA−AA−3525−01 TCGA−G4−6310−01 TCGA−G4−6293−01 TCGA−D5−6541−01 TCGA−CM−5861−01 TCGA−AA−3662−01 TCGA−D5−6533−01 TCGA−G4−6317−01 TCGA−AF−3913−01 TCGA−AA−A00R−01 TCGA−AA−3947−01 TCGA−AA−3543−01 TCGA−CM−6678−01 TCGA−CM−5860−01 TCGA−CK−5916−01 TCGA−CK−5912−01 TCGA−AA−3855−01 TCGA−AA−3815−01 TCGA−AA−3510−01 TCGA−F4−6570−01 TCGA−DM−A1HA−01 TCGA−D5−6536−01 TCGA−D5−6532−01 TCGA−AD−5900−01 TCGA−AA−3514−01 TCGA−AA−A00N−01 TCGA−D5−6930−01 TCGA−AU−3779−01 TCGA−AA−3672−01 TCGA−F4−6856−01 TCGA−F4−6806−01 TCGA−CM−6161−01 TCGA−A6−2676−01 TCGA−AA−A010−01 TCGA−CA−6718−01 TCGA−G4−6588−01 TCGA−CM−4743−01 TCGA−AA−3715−01 TCGA−A6−6141−01 TCGA−A6−5661−01 TCGA−DC−6158−01 TCGA−CI−6624−01 TCGA−AZ−5403−01 TCGA−AA−A01R−01 TCGA−AA−3864−01 TCGA−G4−6628−01 TCGA−AG−A002−01 TCGA−AA−3977−01 TCGA−D5−6928−01 TCGA−CA−6717−01 TCGA−CM−6171−01 TCGA−CM−6162−01 TCGA−EI−6507−01 TCGA−AY−6196−01 TCGA−AD−6964−01 TCGA−AA−3710−01 TCGA−G4−6586−01 TCGA−CK−4952−01 TCGA−CK−4948−01 TCGA−AY−6197−01 TCGA−AD−6895−01 TCGA−AA−A01P−01 TCGA−A6−6781−01 TCGA−A6−5665−01 TCGA−A6−5657−01

TCGA−CL−5917−01 TCGA−AA−3518−01 TCGA−AA−3688−01 TCGA−AG−3587−01 TCGA−D5−6931−01 TCGA−AA−A03J−01 TCGA−AA−A03F−01 TCGA−AA−3855−01 TCGA−DM−A0XF−01 TCGA−AY−5543−01 TCGA−DM−A28C−01 TCGA−AF−2691−01 TCGA−AA−A01K−01 TCGA−AA−3814−01 TCGA−D5−6533−01 TCGA−CM−5862−01 TCGA−AA−3534−01 TCGA−AA−3877−01 TCGA−DC−6160−01 TCGA−AG−4008−01 TCGA−AG−3732−01 TCGA−F4−6703−01 TCGA−F5−6811−01 TCGA−DC−6682−01 TCGA−CI−6622−01 TCGA−AG−3601−01 TCGA−EI−6506−01 TCGA−EF−5830−01 TCGA−D5−6926−01 TCGA−AD−6899−01 TCGA−A6−6137−01 TCGA−DM−A28F−01 TCGA−AA−3655−01 TCGA−G4−6315−01 TCGA−DM−A1D6−01 TCGA−AA−A01P−01 TCGA−G4−6303−01 TCGA−AY−6386−01 TCGA−AA−A02O−01 TCGA−AA−A02K−01 TCGA−AA−A01G−01 TCGA−AA−3531−01 TCGA−CM−6162−01 TCGA−DM−A1HA−01 TCGA−AA−3516−01 TCGA−F4−6856−01 TCGA−DC−6158−01 TCGA−CM−4747−01 TCGA−AA−3542−01 TCGA−CM−5861−01 TCGA−AG−A036−01 TCGA−F4−6855−01 TCGA−D5−5537−01 TCGA−CK−6747−01 TCGA−CA−5255−01 TCGA−AA−3556−01 TCGA−CK−4948−01 TCGA−AY−6196−01 TCGA−G4−6307−01 TCGA−EI−6510−01 TCGA−CM−6166−01 TCGA−AA−A004−01 TCGA−AA−3664−01 TCGA−G4−6317−01 TCGA−DM−A0X9−01 TCGA−A6−3809−01 TCGA−D5−6923−01 TCGA−D5−6532−01 TCGA−CM−5341−01 TCGA−AZ−4682−01 TCGA−AA−3821−01 TCGA−D5−5541−01 TCGA−CK−5915−01 TCGA−AZ−6605−01 TCGA−AG−3608−01 TCGA−AG−3580−01 TCGA−AF−5654−01 TCGA−A6−4105−01 TCGA−D5−6932−01 TCGA−AA−3815−01 TCGA−AA−3543−01 TCGA−G5−6641−01 TCGA−EI−6508−01 TCGA−D5−6924−01 TCGA−AH−6644−01 TCGA−AA−A01F−01 TCGA−AA−3979−01 TCGA−A6−6781−01 TCGA−D5−6536−01 TCGA−G4−6625−01 TCGA−AA−3685−01 TCGA−G4−6310−01 TCGA−DM−A1D8−01 TCGA−DM−A1D0−01 TCGA−DC−6157−01 TCGA−AA−3956−01 TCGA−AA−3866−01 TCGA−D5−6541−01 TCGA−DM−A28E−01 TCGA−D5−7000−01 TCGA−D5−6534−01 TCGA−CA−5254−01 TCGA−AZ−5407−01 TCGA−AG−3890−01 TCGA−AG−3882−01 TCGA−AG−3612−01 TCGA−AA−3930−01 TCGA−AA−3538−01 TCGA−AA−3811−01 TCGA−DM−A0XD−01 TCGA−D5−6535−01 TCGA−AU−3779−01 TCGA−AD−6895−01 TCGA−G4−6309−01 TCGA−DY−A1DF−01 TCGA−AY−4070−01 TCGA−AF−6672−01 TCGA−AA−A00R−01 TCGA−AA−3496−01 TCGA−A6−2670−01 TCGA−AA−3713−01 TCGA−G4−6304−01 TCGA−DM−A1DB−01 TCGA−AA−3867−01 TCGA−D5−5539−01 TCGA−CM−6677−01 TCGA−CK−4947−01 TCGA−A6−2672−01 TCGA−G4−6321−01 TCGA−D5−6539−01 TCGA−CM−5868−01 TCGA−AZ−6603−01 TCGA−AH−6547−01 TCGA−AG−A01Y−01 TCGA−G4−6628−01 TCGA−AZ−6601−01 TCGA−A6−6141−01 TCGA−AA−3697−01 TCGA−AA−3662−01 TCGA−CM−6161−01 TCGA−CM−5349−01 TCGA−AA−A00A−01 TCGA−DT−5265−01 TCGA−DC−6155−01 TCGA−DC−5869−01 TCGA−CM−6679−01 TCGA−AG−3609−01 TCGA−AA−A01Z−01 TCGA−AA−3975−01 TCGA−A6−5657−01 TCGA−G4−6588−01 TCGA−CK−6746−01 TCGA−AU−6004−01 TCGA−AA−A01Q−01 TCGA−AA−3950−01 TCGA−AA−3949−01 TCGA−AA−3525−01 TCGA−G4−6626−01 TCGA−F4−6460−01 TCGA−G4−6299−01 TCGA−DM−A1D9−01 TCGA−CK−6751−01 TCGA−CK−4952−01 TCGA−AZ−6598−01 TCGA−AA−3968−01 TCGA−AA−3850−01 TCGA−AA−3712−01 TCGA−AA−3681−01 TCGA−CM−6167−01 TCGA−AF−6655−01 TCGA−AA−A02Y−01 TCGA−AA−3710−01 TCGA−A6−5661−01 TCGA−G4−6586−01 TCGA−CM−5348−01 TCGA−D5−6930−01 TCGA−CM−4746−01 TCGA−AA−A00E−01 TCGA−EI−6507−01 TCGA−A6−6780−01 TCGA−AG−3727−01 TCGA−AA−A02J−01 TCGA−A6−5662−01 TCGA−G4−6293−01 TCGA−DY−A1DG−01 TCGA−DM−A28H−01 TCGA−DM−A28G−01 TCGA−CM−6169−01 TCGA−AZ−6599−01 TCGA−AZ−5403−01 TCGA−AD−6964−01 TCGA−AA−3994−01 TCGA−AA−3819−01 TCGA−AA−3511−01 TCGA−A6−3810−01 TCGA−AA−3510−01 TCGA−D5−6540−01 TCGA−CM−6171−01 TCGA−AA−3672−01 TCGA−AA−A01R−01 TCGA−AA−3947−01 TCGA−A6−5665−01 TCGA−A6−2676−01 TCGA−D5−6537−01 TCGA−CK−4950−01 TCGA−A6−6653−01 TCGA−D5−6538−01 TCGA−AA−3660−01 TCGA−G4−6323−01 TCGA−DM−A285−01 TCGA−CK−5913−01 TCGA−AH−6549−01 TCGA−AD−6548−01 TCGA−AA−3693−01 TCGA−A6−6142−01 TCGA−DC−6683−01 TCGA−CM−6676−01 TCGA−CM−6170−01 TCGA−CM−6168−01 TCGA−CK−5914−01 TCGA−CI−6621−01 TCGA−CA−6716−01 TCGA−AG−3902−01 TCGA−AA−3941−01 TCGA−AA−3695−01 TCGA−AA−3544−01 TCGA−A6−5659−01 TCGA−AG−A002−01 TCGA−CA−6717−01 TCGA−AZ−4315−01 TCGA−AA−A010−01 TCGA−CA−6718−01 TCGA−AA−3977−01 TCGA−AA−3984−01 TCGA−CM−4743−01 TCGA−AG−A02N−01 TCGA−AA−3715−01 TCGA−AA−A00N−01 TCGA−AA−3864−01 TCGA−AA−3663−01 TCGA−CK−5916−01 TCGA−AY−6197−01 TCGA−AA−A022−01 TCGA−AA−3492−01 TCGA−F4−6570−01 TCGA−D5−6928−01 TCGA−CM−6674−01 TCGA−AD−6889−01 TCGA−AD−5900−01 TCGA−AA−3845−01 TCGA−AA−3555−01 TCGA−AG−3892−01 TCGA−AA−3554−01 TCGA−G4−6306−01 TCGA−F4−6809−01 TCGA−AH−6643−01 TCGA−AA−A00J−01 TCGA−AA−3966−01 TCGA−F4−6808−01 TCGA−D5−6929−01 TCGA−D5−6927−01 TCGA−AG−A020−01 TCGA−AG−3600−01 TCGA−AA−A01V−01 TCGA−AA−A00D−01 TCGA−AA−3552−01 TCGA−AA−3548−01

IFN Gamma Signaling Pathway(JAK1 JAK2 STAT1) ( IFN Gamma Signaling(JAK1 JAK2 STAT1) ) FDR = 2.5e−12%, FDR nod = 2.3e−11% IFN Gamma Pathway FDR = 1.9e−12%, FDR nod = 0.26%

TCGA−AD−5900−01 TCGA−AF−6136−01 TCGA−AA−3877−01 TCGA−AZ−4315−01 TCGA−A6−6654−01 TCGA−G4−6588−01 TCGA−DC−6158−01 TCGA−CM−4743−01 TCGA−CI−6624−01 TCGA−AZ−5403−01 TCGA−AA−A01R−01 TCGA−AA−3864−01 TCGA−AA−3715−01 TCGA−A6−6141−01 TCGA−A6−5661−01 TCGA−AA−3977−01 TCGA−D5−6928−01 TCGA−CM−6162−01 TCGA−G4−6628−01 TCGA−G4−6586−01 TCGA−EI−6507−01 TCGA−CM−6171−01 TCGA−CK−4952−01 TCGA−CK−4948−01 TCGA−AY−6197−01 TCGA−AD−6964−01 TCGA−AD−6895−01 TCGA−AA−A01P−01 TCGA−AA−3710−01 TCGA−A6−6781−01 TCGA−A6−5657−01 TCGA−CA−6717−01 TCGA−AG−A002−01 TCGA−CA−6718−01 TCGA−A6−5665−01 TCGA−G4−6309−01 TCGA−AZ−6598−01 TCGA−AY−6196−01 TCGA−AA−A010−01 TCGA−AA−A00N−01 TCGA−G4−6625−01 TCGA−G4−6293−01 TCGA−F4−6807−01 TCGA−F4−6704−01 TCGA−F4−6569−01 TCGA−EI−6508−01 TCGA−EF−5830−01 TCGA−DM−A0XD−01 TCGA−DC−6683−01 TCGA−DC−5869−01 TCGA−D5−6929−01 TCGA−D5−6541−01 TCGA−D5−6533−01 TCGA−D5−6532−01 TCGA−CM−6170−01 TCGA−CM−6169−01 TCGA−CM−6161−01 TCGA−CM−5868−01 TCGA−CM−5862−01 TCGA−CM−5860−01 TCGA−CM−4746−01 TCGA−CK−6746−01 TCGA−CA−6719−01 TCGA−AZ−6607−01 TCGA−AZ−6606−01 TCGA−AZ−4616−01 TCGA−AY−5543−01 TCGA−AU−6004−01 TCGA−AF−6672−01 TCGA−AA−A02K−01 TCGA−AA−3984−01 TCGA−AA−3966−01 TCGA−AA−3950−01 TCGA−AA−3815−01 TCGA−AA−3713−01 TCGA−AA−3662−01 TCGA−AA−3660−01 TCGA−A6−5666−01 TCGA−A6−5662−01

TCGA−AA−3514−01 TCGA−AA−A01Q−01 TCGA−AA−3930−01 TCGA−AA−3819−01 TCGA−AG−A032−01 TCGA−AA−3870−01 TCGA−EI−6506−01 TCGA−AA−A01P−01 TCGA−AA−3831−01 TCGA−AZ−6605−01 TCGA−D5−6928−01 TCGA−AA−3538−01 TCGA−AA−A02H−01 TCGA−AA−3526−01 TCGA−CM−5863−01 TCGA−AA−3846−01 TCGA−D5−6930−01 TCGA−AA−3994−01 TCGA−AZ−6603−01 TCGA−AZ−6600−01 TCGA−AA−3968−01 TCGA−D5−6533−01 TCGA−AY−6196−01 TCGA−F4−6704−01 TCGA−CM−6170−01 TCGA−AZ−6607−01 TCGA−AA−A02K−01 TCGA−G4−6306−01 TCGA−DY−A1H8−01 TCGA−DY−A1DD−01 TCGA−DM−A28F−01 TCGA−CM−6675−01 TCGA−CK−5915−01 TCGA−AG−A036−01 TCGA−AF−4110−01 TCGA−AA−A01R−01 TCGA−DM−A28E−01 TCGA−DY−A1DF−01 TCGA−AG−3902−01 TCGA−AG−3582−01 TCGA−AA−3986−01 TCGA−AA−3941−01 TCGA−AA−3855−01 TCGA−AD−6895−01 TCGA−G4−6626−01 TCGA−EI−6508−01 TCGA−D5−6922−01 TCGA−CM−6167−01 TCGA−AG−A025−01 TCGA−AG−3726−01 TCGA−AA−3833−01 TCGA−AA−3664−01 TCGA−AA−3552−01 TCGA−AD−6889−01 TCGA−A6−6653−01 TCGA−CM−5868−01 TCGA−CK−5913−01 TCGA−AA−A00J−01 TCGA−G5−6641−01 TCGA−DM−A1D0−01 TCGA−D5−6539−01 TCGA−CA−5796−01 TCGA−AG−3732−01 TCGA−AA−A01G−01 TCGA−AA−A00R−01 TCGA−AA−3554−01 TCGA−AA−3527−01 TCGA−AA−3966−01 TCGA−D5−6535−01 TCGA−AA−A022−01 TCGA−AA−3811−01 TCGA−AA−3672−01 TCGA−EI−6510−01 TCGA−DM−A1DA−01 TCGA−D5−5537−01 TCGA−AH−6549−01 TCGA−AA−3518−01 TCGA−AA−3516−01 TCGA−F5−6812−01 TCGA−CI−6620−01 TCGA−AA−A029−01 TCGA−AA−A00E−01 TCGA−AA−3973−01 TCGA−AG−A002−01 TCGA−G4−6309−01 TCGA−AA−3984−01 TCGA−A6−6781−01 TCGA−AG−3892−01 TCGA−AA−3555−01 TCGA−CA−6716−01 TCGA−AA−3949−01 TCGA−AA−3710−01 TCGA−DM−A28K−01 TCGA−AA−3821−01 TCGA−F4−6806−01 TCGA−DM−A282−01 TCGA−DM−A1D4−01 TCGA−AA−A00K−01 TCGA−AA−3980−01 TCGA−AA−3867−01 TCGA−AA−3854−01 TCGA−AA−3666−01 TCGA−A6−6651−01 TCGA−CA−6717−01 TCGA−AA−A010−01 TCGA−AZ−4315−01 TCGA−G4−6628−01 TCGA−AA−3977−01 TCGA−AZ−6598−01 TCGA−AA−3815−01 TCGA−G4−6588−01 TCGA−AU−6004−01 TCGA−AD−5900−01 TCGA−AA−3715−01 TCGA−AA−3713−01 TCGA−AA−3663−01 TCGA−AA−3510−01 TCGA−A6−5665−01 TCGA−EI−6507−01 TCGA−CM−6171−01 TCGA−CM−4743−01 TCGA−CA−6718−01 TCGA−AY−5543−01 TCGA−AA−A00N−01 TCGA−AA−3877−01 TCGA−AA−3864−01 TCGA−AA−3662−01 TCGA−A6−5661−01 TCGA−G4−6586−01 TCGA−G4−6307−01 TCGA−CM−6162−01 TCGA−CM−5862−01 TCGA−CM−4752−01 TCGA−AZ−6601−01 TCGA−AD−6964−01 TCGA−A6−6141−01 TCGA−F4−6570−01 TCGA−EF−5830−01 TCGA−DM−A1HA−01 TCGA−DM−A1DB−01 TCGA−D5−6931−01 TCGA−D5−6540−01 TCGA−D5−6532−01 TCGA−CM−6674−01 TCGA−CM−6164−01 TCGA−CK−6746−01 TCGA−CK−4947−01 TCGA−AZ−6608−01 TCGA−AU−3779−01 TCGA−AA−3947−01 TCGA−AA−3697−01 TCGA−AA−3660−01 TCGA−AA−3511−01 TCGA−AA−3492−01 TCGA−A6−6780−01 TCGA−G4−6625−01 TCGA−G4−6310−01 TCGA−G4−6304−01 TCGA−G4−6293−01 TCGA−F4−6460−01 TCGA−DY−A0XA−01 TCGA−DM−A1D7−01 TCGA−DM−A0XD−01 TCGA−DC−6682−01 TCGA−DC−5869−01 TCGA−D5−6927−01 TCGA−D5−6923−01 TCGA−D5−6541−01 TCGA−D5−5540−01 TCGA−CM−6676−01 TCGA−CM−6161−01 TCGA−CM−5864−01 TCGA−CM−5861−01 TCGA−CM−4746−01 TCGA−CK−5916−01 TCGA−CK−5914−01 TCGA−CK−4952−01 TCGA−CK−4948−01 TCGA−CA−6719−01 TCGA−AZ−6599−01 TCGA−AY−6386−01 TCGA−AY−6197−01 TCGA−AH−6643−01 TCGA−AF−6136−01 TCGA−AF−2687−01 TCGA−AA−3950−01 TCGA−AA−3655−01 TCGA−A6−5666−01 TCGA−A6−5662−01 TCGA−A6−5657−01 TCGA−G5−6235−01 TCGA−G4−6323−01 TCGA−G4−6315−01 TCGA−G4−6303−01 TCGA−G4−6299−01 TCGA−F5−6813−01 TCGA−F4−6808−01 TCGA−F4−6807−01 TCGA−F4−6569−01 TCGA−DY−A1DG−01 TCGA−DY−A1DC−01 TCGA−DT−5265−01 TCGA−DM−A28H−01 TCGA−DM−A1D9−01 TCGA−DM−A1D8−01 TCGA−DM−A0X9−01 TCGA−DC−6683−01 TCGA−DC−6158−01 TCGA−D5−6929−01 TCGA−D5−6920−01 TCGA−D5−6538−01 TCGA−D5−6536−01 TCGA−D5−6534−01 TCGA−D5−5541−01 TCGA−D5−5538−01 TCGA−CM−6680−01 TCGA−CM−6678−01 TCGA−CM−6172−01 TCGA−CM−6169−01 TCGA−CM−6168−01 TCGA−CM−6166−01 TCGA−CM−5860−01 TCGA−CM−5349−01 TCGA−CM−5344−01 TCGA−CK−6747−01 TCGA−CK−4950−01 TCGA−CI−6624−01 TCGA−CI−6619−01 TCGA−AZ−6606−01 TCGA−AZ−5407−01 TCGA−AZ−5403−01 TCGA−AZ−4682−01 TCGA−AZ−4616−01 TCGA−AH−6544−01 TCGA−AG−A02N−01 TCGA−AG−4015−01 TCGA−AG−3742−01 TCGA−AG−3731−01 TCGA−AF−6672−01 TCGA−AF−2693−01 TCGA−AD−6963−01 TCGA−AD−6548−01 TCGA−AA−3956−01 TCGA−AA−3818−01 TCGA−AA−3712−01 TCGA−A6−6654−01 TCGA−A6−5660−01 TCGA−A6−5659−01 TCGA−A6−5656−01 TCGA−A6−4105−01 TCGA−G4−6317−01 TCGA−F5−6811−01 TCGA−F5−6571−01 TCGA−F4−6856−01 TCGA−F4−6855−01 TCGA−F4−6854−01 TCGA−F4−6809−01 TCGA−F4−6805−01 TCGA−F4−6459−01 TCGA−DM−A28G−01 TCGA−DM−A28C−01 TCGA−DM−A285−01 TCGA−DM−A0XF−01 TCGA−DC−6160−01 TCGA−DC−6157−01 TCGA−D5−7000−01 TCGA−D5−6926−01 TCGA−D5−6898−01 TCGA−D5−6537−01 TCGA−D5−6529−01 TCGA−D5−5539−01 TCGA−CM−4747−01 TCGA−CL−5918−01 TCGA−CL−5917−01 TCGA−CK−5912−01 TCGA−CI−6622−01 TCGA−AH−6644−01 TCGA−AG−A020−01 TCGA−AG−A00H−01 TCGA−AG−3901−01 TCGA−AG−3887−01 TCGA−AG−3878−01 TCGA−AD−6965−01 TCGA−AD−6899−01 TCGA−AD−6890−01 TCGA−AA−A03J−01 TCGA−AA−A03F−01 TCGA−AA−A02Y−01 TCGA−AA−A02O−01 TCGA−AA−A01V−01 TCGA−AA−A01K−01 TCGA−AA−A01I−01 TCGA−AA−3939−01 TCGA−AA−3866−01 TCGA−AA−3852−01 TCGA−AA−3850−01 TCGA−AA−3848−01 TCGA−AA−3837−01 TCGA−AA−3812−01 TCGA−AA−3696−01 TCGA−AA−3673−01 TCGA−AA−3496−01 TCGA−AA−3489−01 TCGA−A6−6782−01 TCGA−A6−6652−01 TCGA−A6−6649−01 TCGA−A6−3809−01 TCGA−A6−3808−01

IRF3 Mediated Induction Of Type I IFN FDR = 2.2e−07%, FDR nod = 2.2e−07% IRF3 Mediated Activation Of Type 1 IFN FDR = 0.04%, FDR nod = 0.056%


JAK2


wt wt

JAK1

STAT1

IFNG

IFNGR1

IFNGR2

PIK3CA MTOR CREBBP EP300 PIK3R1 DAPK1 PTPN11 JAK2 CBL CAMK2A CAMK2B CAMK2D IRF9 AKT1 IRF1 JAK1 MAP2K1 MAPK1 MAPK3 PIAS4 PTPN2 RAP1B CALM2 CALM3 CAMK2G CASP1 CEBPB CRKL IFNG IFNGR1 IL1B MAP3K11 PIAS1 PRKCD PTGES2 RAP1A RAPGEF1 SMAD7 STAT1 STAT3

known HCG mut

JAK1

STAT1

unknown CG mut

STAT3



DTX4

TBK1

DTX4

XRCC6

XRCC5

TBK1

IFI16

IRF3

IRF3

DDX41

TMEM173

TMEM173

TREX1

wt MRE11A wt

wt IFNA1

known HCG mut

wt

IFNA2

IFNAR1 STAT2

IFNA10 IFNA5 TYK2

IFNA14

IFNA21

IFNAR2 IFNA13

IFNA16

IFNA17 IFNA4

IFNA8

IFNA6

IFNA7 IRF9

DOCK2 PREX2 KALRN TRIO TIAM1 VAV3 ARHGEF7 MCF2 ELMO1 PREX1 ARHGEF25 ARHGAP32 DOCK1 RASGRF1 SPATA13 VAV1 DOCK6 NGEF SOS1 RASGRF2 VAV2 ARHGAP9 ARHGEF6 CHN2 TIAM2 ABI1 ABR ARHGEF2 DEF6 RACGAP1 ARHGAP1 ARHGAP17 ARHGDIA BCR CHN1 EPS8 RAC1 RALBP1 RAP1GDS1

unknown CG mut

IFN Alpha Signaling Pathway((JAK1 TYK2 STAT1 STAT2) ( IFN Alpha Signaling(JAK1 TYK2 STAT1 STAT2 STAT3) ) IFN Alpha Signaling Pathway(JAK1 TYK2 STAT1 STAT3) ( IFN Alpha Signaling(JAK1 TYK2 STAT1 STAT2 STAT3) ) IFN Alpha Signaling Pathway(JAK1 TYK2 STAT1) ( IFN Alpha Signaling(JAK1 TYK2 STAT1 STAT2 STAT3) ) IFN Alpha Signaling Pathway(JAK1 TYK2 STAT3) ( IFN Alpha Signaling(JAK1 TYK2 STAT1 STAT2 STAT3) ) FDR = 2.5%, FDR nod = 2.5%

Regulation Of RAC1 Activity FDR = 1.1e−08%, FDR nod = 2.6e−10%

NLRP4

PRKDC

NLRP4

ZBP1 ZBP1

TCGA−A6−2672−01 TCGA−AG−A016−01 TCGA−DM−A1HA−01 TCGA−D5−6540−01 TCGA−A6−2676−01 TCGA−DM−A1D6−01 TCGA−D5−6928−01 TCGA−CM−6171−01 TCGA−G4−6309−01 TCGA−D5−6922−01 TCGA−AA−A01R−01 TCGA−AA−3710−01 TCGA−AA−3986−01 TCGA−AA−3713−01 TCGA−CM−5861−01 TCGA−CM−4743−01 TCGA−DM−A0XD−01 TCGA−D5−6534−01 TCGA−CM−6677−01 TCGA−CK−6746−01 TCGA−EI−6507−01 TCGA−CM−6172−01 TCGA−AZ−6600−01 TCGA−AZ−4681−01 TCGA−AH−6547−01 TCGA−AA−A00R−01 TCGA−AA−A00J−01 TCGA−AA−3524−01 TCGA−AZ−6598−01 TCGA−AG−3892−01 TCGA−CM−6674−01 TCGA−AA−3672−01 TCGA−A6−5661−01 TCGA−D5−6931−01 TCGA−D5−6930−01 TCGA−AA−3950−01 TCGA−AA−3525−01 TCGA−AA−3516−01 TCGA−DM−A28G−01 TCGA−D5−6536−01 TCGA−CK−5916−01 TCGA−CA−5796−01 TCGA−AG−A01Y−01 TCGA−AG−4001−01 TCGA−AG−3593−01 TCGA−AD−5900−01 TCGA−AA−3977−01 TCGA−AA−3695−01 TCGA−AA−3684−01 TCGA−AA−3662−01 TCGA−AA−3660−01 TCGA−AA−3502−01 TCGA−CA−6717−01 TCGA−AA−A010−01 TCGA−AG−A002−01 TCGA−AA−3715−01 TCGA−G4−6588−01 TCGA−G4−6628−01 TCGA−G4−6586−01 TCGA−AZ−4315−01 TCGA−AG−A02N−01 TCGA−AD−6889−01 TCGA−AA−A00N−01 TCGA−AA−3984−01 TCGA−A6−5665−01 TCGA−G4−6304−01 TCGA−F4−6856−01 TCGA−F4−6854−01 TCGA−DM−A28H−01 TCGA−CM−6161−01 TCGA−CK−4952−01 TCGA−CA−6718−01 TCGA−AZ−6601−01 TCGA−AA−3864−01 TCGA−AA−3811−01 TCGA−AA−3663−01 TCGA−AA−3492−01 TCGA−A6−6781−01 TCGA−A6−6780−01 TCGA−A6−6141−01 TCGA−G5−6235−01 TCGA−G4−6625−01 TCGA−G4−6317−01 TCGA−G4−6315−01 TCGA−G4−6307−01 TCGA−G4−6306−01 TCGA−G4−6303−01 TCGA−G4−6293−01 TCGA−F4−6703−01 TCGA−F4−6570−01 TCGA−DM−A28K−01 TCGA−D5−6927−01 TCGA−D5−6537−01 TCGA−D5−6535−01 TCGA−D5−6532−01 TCGA−D5−5540−01 TCGA−CM−6680−01 TCGA−CM−6676−01 TCGA−CM−6166−01 TCGA−CM−5860−01 TCGA−CM−5349−01 TCGA−CK−5913−01 TCGA−CK−4948−01 TCGA−AZ−6608−01 TCGA−AZ−6607−01 TCGA−AY−6197−01 TCGA−AU−3779−01 TCGA−AG−A011−01 TCGA−AF−4110−01 TCGA−AD−6964−01 TCGA−AD−6895−01 TCGA−AA−A01P−01 TCGA−AA−3930−01 TCGA−AA−3815−01 TCGA−AA−3655−01 TCGA−A6−6653−01 TCGA−A6−5666−01 TCGA−A6−5659−01 TCGA−A6−5657−01 TCGA−A6−5656−01 TCGA−A6−3809−01

TCGA−G4−6588−01 TCGA−AG−A02N−01 TCGA−AG−A016−01 TCGA−A6−6780−01 TCGA−A6−5665−01 TCGA−G4−6309−01 TCGA−G4−6304−01 TCGA−D5−6922−01 TCGA−AA−A01R−01 TCGA−G4−6586−01 TCGA−AA−3986−01 TCGA−AA−3713−01 TCGA−AA−3710−01 TCGA−AA−3663−01 TCGA−A6−6781−01 TCGA−AA−3715−01 TCGA−EI−6507−01 TCGA−CM−6172−01 TCGA−AZ−6600−01 TCGA−AZ−4681−01 TCGA−AH−6547−01 TCGA−AA−A00R−01 TCGA−AA−A00J−01 TCGA−AA−3984−01 TCGA−AA−3524−01 TCGA−AZ−6598−01 TCGA−AA−A010−01 TCGA−CM−6674−01 TCGA−AG−A002−01 TCGA−AG−3892−01 TCGA−AA−3672−01 TCGA−AA−3516−01 TCGA−A6−5661−01 TCGA−F4−6854−01 TCGA−DM−A28G−01 TCGA−D5−6931−01 TCGA−D5−6930−01 TCGA−D5−6536−01 TCGA−CK−5916−01 TCGA−CK−4952−01 TCGA−CA−6717−01 TCGA−CA−5796−01 TCGA−AG−A01Y−01 TCGA−AG−4001−01 TCGA−AG−3593−01 TCGA−AD−5900−01 TCGA−AA−A00N−01 TCGA−AA−3977−01 TCGA−AA−3950−01 TCGA−AA−3864−01 TCGA−AA−3695−01 TCGA−AA−3684−01 TCGA−AA−3662−01 TCGA−AA−3660−01 TCGA−AA−3525−01 TCGA−AA−3502−01

Regulation Of IFNA Signaling FDR = 1.9e−07%, FDR nod = 0.54% LRR FLII Interacting Protein 1 (LRRFIP1) Activates Type I IFN Production FDR = 1.9e−12%, FDR nod = 0.021%

TCGA−A6−6653−01 TCGA−G5−6235−01 TCGA−AA−A02J−01 TCGA−AZ−6600−01 TCGA−AD−6548−01 TCGA−G4−6625−01 TCGA−CM−4744−01 TCGA−AG−3894−01 TCGA−AA−A022−01 TCGA−A6−6780−01 TCGA−AA−3949−01 TCGA−AA−3811−01 TCGA−G4−6304−01 TCGA−AA−3818−01 TCGA−AA−3663−01 TCGA−DM−A1D4−01 TCGA−CM−6164−01 TCGA−AG−3892−01 TCGA−AD−6889−01 TCGA−AA−3525−01 TCGA−AA−3510−01 TCGA−AA−3516−01 TCGA−AA−3489−01 TCGA−A6−2671−01 TCGA−G4−6293−01 TCGA−D5−6541−01 TCGA−CM−5861−01 TCGA−AA−3662−01 TCGA−D5−6533−01 TCGA−G4−6317−01 TCGA−AF−3913−01 TCGA−AA−A00R−01 TCGA−AA−3947−01 TCGA−AA−3543−01 TCGA−CM−6678−01 TCGA−CM−5860−01 TCGA−CK−5916−01 TCGA−CK−5912−01 TCGA−AA−3855−01 TCGA−AA−3815−01 TCGA−AA−3984−01 TCGA−CM−6674−01 TCGA−AZ−6603−01 TCGA−AA−A01Q−01 TCGA−AA−A00K−01 TCGA−AA−A00E−01 TCGA−AA−3713−01 TCGA−AA−A00N−01 TCGA−D5−6930−01 TCGA−CM−6161−01 TCGA−AA−3672−01 TCGA−F4−6856−01 TCGA−F4−6806−01 TCGA−AU−3779−01 TCGA−A6−2676−01 TCGA−AA−A010−01 TCGA−CM−4743−01 TCGA−AA−3864−01 TCGA−AA−3715−01 TCGA−A6−6141−01 TCGA−A6−5661−01 TCGA−DC−6158−01 TCGA−CI−6624−01 TCGA−AZ−5403−01 TCGA−AA−A01R−01 TCGA−CA−6717−01 TCGA−G4−6628−01 TCGA−D5−6928−01 TCGA−CM−6162−01 TCGA−AA−3710−01 TCGA−EI−6507−01 TCGA−CM−6171−01 TCGA−AY−6196−01 TCGA−A6−6781−01 TCGA−G4−6586−01 TCGA−CK−4952−01 TCGA−CK−4948−01 TCGA−AY−6197−01 TCGA−AD−6895−01 TCGA−AA−A01P−01 TCGA−A6−5665−01 TCGA−A6−5657−01 TCGA−AG−A002−01 TCGA−AA−3977−01 TCGA−G4−6588−01 TCGA−CA−6718−01 TCGA−AZ−6601−01 TCGA−G4−6310−01 TCGA−AZ−6608−01 TCGA−AD−6964−01 TCGA−AA−3655−01 TCGA−G4−6307−01 TCGA−G4−6306−01 TCGA−G4−6303−01 TCGA−G4−6299−01 TCGA−DY−A1H8−01 TCGA−DY−A1DD−01 TCGA−DY−A1DC−01 TCGA−DY−A0XA−01 TCGA−DM−A28F−01 TCGA−DM−A1HA−01 TCGA−DM−A0X9−01 TCGA−D5−6538−01 TCGA−D5−6535−01 TCGA−D5−6534−01 TCGA−CM−6676−01 TCGA−CM−6675−01 TCGA−CM−5862−01 TCGA−CK−6747−01 TCGA−CK−5915−01 TCGA−CK−5914−01 TCGA−AZ−6599−01 TCGA−AZ−6598−01 TCGA−AH−6643−01 TCGA−AG−A036−01 TCGA−AG−4015−01 TCGA−AF−4110−01 TCGA−AF−2693−01 TCGA−AA−3712−01 TCGA−AA−3697−01 TCGA−AA−3660−01 TCGA−AA−3555−01

TCGA−AG−A016−01 TCGA−DY−A1H8−01 TCGA−AY−4070−01 TCGA−A6−6653−01 TCGA−G5−6641−01 TCGA−G5−6235−01 TCGA−DM−A1D0−01 TCGA−D5−6931−01 TCGA−D5−6539−01 TCGA−CM−6162−01 TCGA−CM−5868−01 TCGA−CK−5913−01 TCGA−CI−6619−01 TCGA−CA−5796−01 TCGA−AY−6386−01 TCGA−AF−2687−01 TCGA−AD−6889−01 TCGA−AA−A01G−01 TCGA−AA−A00R−01 TCGA−AA−A00J−01 TCGA−AA−3555−01 TCGA−AA−3554−01 TCGA−AA−3527−01 TCGA−A6−6781−01 TCGA−A6−6141−01 TCGA−A6−5659−01 TCGA−AA−A010−01 TCGA−EI−6507−01 TCGA−DM−A1DA−01 TCGA−AU−6004−01 TCGA−AH−6643−01 TCGA−AG−A02N−01 TCGA−AG−A002−01 TCGA−AA−3966−01 TCGA−AA−3877−01 TCGA−AA−3864−01 TCGA−AA−3715−01 TCGA−AA−3713−01 TCGA−G4−6307−01 TCGA−G4−6304−01 TCGA−G4−6293−01 TCGA−F5−6812−01 TCGA−F4−6808−01 TCGA−F4−6460−01 TCGA−DM−A28H−01 TCGA−DM−A1HA−01 TCGA−DM−A1D8−01 TCGA−D5−6923−01 TCGA−D5−5538−01 TCGA−D5−5537−01 TCGA−CM−6680−01 TCGA−CM−5861−01 TCGA−CK−4948−01 TCGA−CI−6620−01 TCGA−AY−5543−01 TCGA−AH−6549−01 TCGA−AH−6544−01 TCGA−AG−3731−01 TCGA−AD−6963−01 TCGA−AD−5900−01 TCGA−AA−A029−01 TCGA−AA−A022−01 TCGA−AA−A00E−01 TCGA−AA−3984−01 TCGA−AA−3973−01 TCGA−AA−3947−01 TCGA−AA−3818−01 TCGA−AA−3815−01 TCGA−AA−3811−01 TCGA−AA−3672−01 TCGA−AA−3518−01 TCGA−AA−3516−01 TCGA−A6−5665−01 TCGA−G4−6628−01 TCGA−EI−6510−01 TCGA−CM−6168−01 TCGA−CM−6164−01 TCGA−CM−4743−01 TCGA−CA−6717−01 TCGA−AZ−4315−01 TCGA−AA−A00N−01 TCGA−AA−3662−01 TCGA−A6−6780−01 TCGA−G4−6625−01 TCGA−G4−6588−01 TCGA−G4−6586−01 TCGA−G4−6323−01 TCGA−F5−6813−01 TCGA−DM−A1D7−01 TCGA−DC−6682−01 TCGA−D5−6540−01 TCGA−D5−6538−01 TCGA−D5−6535−01 TCGA−D5−5540−01 TCGA−CM−6171−01 TCGA−CM−5349−01 TCGA−CM−5344−01 TCGA−CM−4752−01 TCGA−CK−6746−01 TCGA−CK−5916−01 TCGA−AZ−6601−01 TCGA−AZ−6599−01 TCGA−AU−3779−01 TCGA−AG−3732−01 TCGA−AD−6964−01 TCGA−AA−3655−01 TCGA−AA−3510−01 TCGA−G4−6626−01 TCGA−G4−6315−01 TCGA−G4−6303−01 TCGA−F5−6811−01 TCGA−F5−6571−01 TCGA−F5−6465−01 TCGA−F4−6856−01 TCGA−F4−6855−01 TCGA−F4−6854−01 TCGA−F4−6703−01 TCGA−F4−6569−01 TCGA−DY−A1DG−01 TCGA−DY−A1DF−01 TCGA−DY−A0XA−01 TCGA−DM−A1DB−01 TCGA−DM−A1D6−01 TCGA−DM−A1D4−01 TCGA−DM−A0XF−01 TCGA−DC−5337−01 TCGA−D5−6541−01 TCGA−D5−6537−01 TCGA−D5−6536−01 TCGA−D5−6533−01 TCGA−CM−6675−01 TCGA−CM−6163−01 TCGA−CM−5860−01 TCGA−CM−4747−01 TCGA−CM−4744−01 TCGA−CL−5917−01 TCGA−CK−5915−01 TCGA−CK−4952−01 TCGA−CA−6718−01 TCGA−AZ−6608−01 TCGA−AZ−6605−01 TCGA−AZ−6598−01 TCGA−AZ−5407−01 TCGA−AH−6547−01 TCGA−AG−A020−01 TCGA−AG−3892−01 TCGA−AG−3881−01 TCGA−AG−3575−01 TCGA−AF−6655−01 TCGA−AF−2693−01 TCGA−AD−6901−01 TCGA−AA−A01K−01 TCGA−AA−A00U−01 TCGA−AA−3831−01 TCGA−AA−3712−01 TCGA−AA−3697−01 TCGA−AA−3696−01 TCGA−AA−3663−01 TCGA−AA−3660−01 TCGA−AA−3534−01 TCGA−AA−3496−01 TCGA−A6−5661−01 TCGA−A6−5660−01 TCGA−A6−2678−01

RIG I/MDA5 Mediated Induction Of IFN Alpha/beta Pathways FDR = 0.8%, FDR nod = 0.78% Regulation Of IFNG Signaling FDR = 1.5e−11%, FDR nod = 0.0025%

wt wt CAB39L

known HCG mut known HCG mut TSC2

TCGA−AA−3971−01 TCGA−D5−6920−01 TCGA−D5−6537−01 TCGA−CM−6678−01 TCGA−D5−6928−01 TCGA−AA−A00R−01 TCGA−CK−6747−01 TCGA−AA−3833−01 TCGA−AA−3811−01 TCGA−CK−4948−01 TCGA−AG−A02N−01 TCGA−AA−3977−01 TCGA−A6−6781−01 TCGA−AG−3742−01 TCGA−G4−6304−01 TCGA−DM−A0XF−01 TCGA−AD−6895−01 TCGA−AA−A02W−01 TCGA−AA−A00E−01 TCGA−F4−6856−01 TCGA−F4−6570−01 TCGA−CA−6718−01 TCGA−AF−6655−01 TCGA−AD−6890−01 TCGA−AD−6889−01 TCGA−AA−3968−01 TCGA−AA−3815−01 TCGA−A6−6780−01 TCGA−A6−5664−01 TCGA−A6−5661−01 TCGA−AA−A00N−01 TCGA−CM−6674−01 TCGA−CI−6624−01 TCGA−CA−5796−01 TCGA−CA−5254−01 TCGA−AZ−6601−01 TCGA−AZ−5403−01 TCGA−AA−3526−01 TCGA−A6−6654−01 TCGA−A6−6651−01 TCGA−A6−2672−01 TCGA−CA−6717−01 TCGA−AY−6197−01 TCGA−D5−5539−01 TCGA−CM−6171−01 TCGA−CK−5913−01 TCGA−CI−6622−01 TCGA−AZ−6605−01 TCGA−AG−3593−01 TCGA−AA−A01P−01 TCGA−AA−3952−01 TCGA−AA−3525−01 TCGA−A6−3809−01 TCGA−A6−5665−01 TCGA−AA−A01Q−01 TCGA−AA−3663−01 TCGA−AA−3492−01 TCGA−D5−6540−01 TCGA−AG−3892−01 TCGA−AA−3950−01 TCGA−AA−3710−01 TCGA−G4−6628−01 TCGA−D5−6929−01 TCGA−D5−6927−01 TCGA−CM−4746−01 TCGA−CK−5916−01 TCGA−CK−4952−01 TCGA−AD−6964−01 TCGA−AA−A02F−01 TCGA−AA−A01R−01 TCGA−AA−3947−01 TCGA−A6−6141−01 TCGA−AZ−6598−01 TCGA−AA−A010−01 TCGA−AZ−4315−01 TCGA−G5−6235−01 TCGA−AG−A002−01 TCGA−AA−3982−01 TCGA−AA−3715−01 TCGA−AA−3713−01 TCGA−AA−3510−01 TCGA−G4−6586−01 TCGA−G4−6307−01 TCGA−F4−6854−01 TCGA−EI−6510−01 TCGA−DM−A1D4−01 TCGA−D5−6926−01 TCGA−CM−6675−01 TCGA−CK−5914−01 TCGA−AD−6965−01 TCGA−AD−5900−01 TCGA−AA−3848−01 TCGA−AA−3555−01 TCGA−A6−6649−01 TCGA−A6−5659−01

TCGA−AA−3930−01 TCGA−AD−5900−01 TCGA−A6−6654−01 TCGA−AA−3663−01 TCGA−A6−6653−01 TCGA−AA−3949−01 TCGA−AA−3811−01 TCGA−AF−6136−01 TCGA−AA−3877−01 TCGA−AZ−4315−01 TCGA−AG−3892−01 TCGA−AA−3947−01 TCGA−CM−6674−01 TCGA−AZ−6603−01 TCGA−AA−A01Q−01 TCGA−AA−A00K−01 TCGA−AA−A00E−01 TCGA−AA−3864−01 TCGA−AA−3715−01 TCGA−DC−6158−01 TCGA−CM−4743−01 TCGA−CI−6624−01 TCGA−AZ−5403−01 TCGA−AA−A01R−01 TCGA−A6−6141−01 TCGA−A6−5661−01 TCGA−D5−6928−01 TCGA−CM−6162−01 TCGA−AD−6895−01 TCGA−A6−6781−01 TCGA−G4−6628−01 TCGA−G4−6586−01 TCGA−EI−6507−01 TCGA−CM−6171−01 TCGA−CK−4952−01 TCGA−CK−4948−01 TCGA−AY−6197−01 TCGA−AA−A01P−01 TCGA−AA−3710−01 TCGA−A6−5657−01 TCGA−AA−3977−01 TCGA−AZ−6601−01 TCGA−G4−6588−01 TCGA−AD−6964−01 TCGA−G4−6310−01 TCGA−G4−6307−01 TCGA−G4−6306−01 TCGA−G4−6303−01 TCGA−G4−6299−01 TCGA−DY−A1H8−01 TCGA−DY−A1DD−01 TCGA−DY−A1DC−01 TCGA−DY−A0XA−01 TCGA−DM−A28F−01 TCGA−DM−A1HA−01 TCGA−DM−A0X9−01 TCGA−D5−6538−01 TCGA−D5−6535−01 TCGA−D5−6534−01 TCGA−CM−6676−01 TCGA−CM−6675−01 TCGA−CK−6747−01 TCGA−CK−5915−01 TCGA−CK−5914−01 TCGA−AZ−6608−01 TCGA−AZ−6599−01 TCGA−AH−6643−01 TCGA−AG−A036−01 TCGA−AG−4015−01 TCGA−AF−4110−01 TCGA−AF−2693−01 TCGA−AA−3712−01 TCGA−AA−3697−01 TCGA−AA−3655−01 TCGA−AA−3555−01 TCGA−CA−6717−01 TCGA−AG−A002−01 TCGA−CA−6718−01 TCGA−AZ−6598−01 TCGA−AA−3984−01 TCGA−AA−3660−01 TCGA−A6−5665−01 TCGA−G4−6309−01 TCGA−CM−5862−01 TCGA−AY−6196−01 TCGA−AA−A010−01 TCGA−AA−A00N−01 TCGA−AA−3713−01 TCGA−G4−6625−01 TCGA−G4−6293−01 TCGA−F4−6807−01 TCGA−F4−6704−01 TCGA−F4−6569−01 TCGA−EI−6508−01 TCGA−EF−5830−01 TCGA−DM−A0XD−01 TCGA−DC−6683−01 TCGA−DC−5869−01 TCGA−D5−6929−01 TCGA−D5−6541−01 TCGA−D5−6533−01 TCGA−D5−6532−01 TCGA−CM−6170−01 TCGA−CM−6169−01 TCGA−CM−6161−01 TCGA−CM−5868−01 TCGA−CM−5860−01 TCGA−CM−4746−01 TCGA−CK−6746−01 TCGA−CA−6719−01 TCGA−AZ−6607−01 TCGA−AZ−6606−01 TCGA−AZ−4616−01 TCGA−AY−5543−01 TCGA−AU−6004−01 TCGA−AF−6672−01 TCGA−AA−A02K−01 TCGA−AA−3966−01 TCGA−AA−3950−01 TCGA−AA−3815−01 TCGA−AA−3662−01 TCGA−A6−5666−01 TCGA−A6−5662−01

Fatty Acids Bound To GPR40 (FFAR1) Regulate Insulin Secretion FDR = 0.56%, FDR nod = 0.64% Energy Dependent Regulation Of MTOR By LKB1 AMPK FDR = 4.4%, FDR nod = 3.2%

unknown CG mut unknown CG mut MTOR

IFNA1 CREBBP

PTPN6 EP300

IFNA17 LRRFIP1

IFNA7 IRF3


HERC5 JAK2

DDX58 JAK1

PTPN1

NLRX1

PIAS1

UBA7

IFNGR1

TKFC

PTPN6

DHX58

SOCS3

RNF135

IFNG

TRIM25

IFNGR2

ISG15

PTPN2

MAVS

PLCB1 STK11

PLCB3 TSC1

GNAQ PPM1A

PRKAA1

PRKAB1

PRKAG1

PLCB2

PRKAG2

RHEB

PRKAG3

GNA14

RRAGC

STRADB

LAMTOR2

LAMTOR4

GNA11

LAMTOR5

RRAGB

CAB39

GNA15

LAMTOR1

LAMTOR3

MLST8

PRKAB2

FFAR1

RRAGA

STRADA

wt STAT2 wt

known HCG mut IFNA2 known HCG mut

wt IFIH1 wt STAT1

STAT1 CTNNB1

known HCG mut NLRC5 known HCG mut PTPN11


PTPN11 JAK1

PTPN1

IFNAR1

IFNA5

IFNA10 IFNB1

IFNAR2

TYK2

USP18

IFNA13

IFNA14

IFNA21 IFNA4

IFNA16 IFNA6

IFNA8

SOCS3

RPTOR

PRKAA2

RRAGD

TCGA−CM−5862−01 TCGA−CK−4952−01 TCGA−D5−6930−01 TCGA−AG−3742−01 TCGA−AA−A01Z−01 TCGA−AA−A01D−01 TCGA−AU−6004−01 TCGA−AA−3526−01 TCGA−A6−6780−01 TCGA−A6−6654−01 TCGA−A6−6141−01 TCGA−DM−A28G−01 TCGA−D5−5538−01 TCGA−AF−2687−01 TCGA−AA−3877−01 TCGA−AA−3821−01 TCGA−AA−3543−01 TCGA−D5−6536−01 TCGA−DM−A1DB−01 TCGA−DM−A1D6−01 TCGA−CK−5914−01 TCGA−AZ−6608−01 TCGA−AF−5654−01 TCGA−AA−3949−01 TCGA−AA−3672−01 TCGA−AZ−6601−01 TCGA−D5−6537−01 TCGA−D5−5541−01 TCGA−CM−6168−01 TCGA−CM−4743−01 TCGA−AZ−6599−01 TCGA−AG−A002−01 TCGA−AD−5900−01 TCGA−AA−3666−01 TCGA−A6−5665−01 TCGA−A6−6781−01 TCGA−A6−5661−01 TCGA−A6−5659−01 TCGA−D5−6928−01 TCGA−D5−6927−01 TCGA−CM−4752−01 TCGA−CK−6746−01 TCGA−CK−5916−01 TCGA−AG−3726−01 TCGA−AD−6895−01 TCGA−AA−A00A−01 TCGA−AA−3864−01 TCGA−AA−3713−01 TCGA−AA−3511−01 TCGA−A6−4105−01 TCGA−A6−2676−01 TCGA−G4−6588−01 TCGA−AZ−4315−01 TCGA−AY−6197−01 TCGA−AA−A010−01 TCGA−AA−A00R−01 TCGA−AA−3977−01 TCGA−AA−3966−01 TCGA−AA−3510−01 TCGA−G4−6628−01 TCGA−G4−6310−01 TCGA−G4−6309−01 TCGA−F4−6856−01 TCGA−DM−A1D9−01 TCGA−D5−6535−01 TCGA−CM−6165−01 TCGA−CM−5348−01 TCGA−AZ−6600−01 TCGA−AH−6547−01 TCGA−AD−6964−01 TCGA−AA−A00N−01 TCGA−AA−3850−01 TCGA−AA−3715−01 TCGA−AA−3710−01 TCGA−A6−5660−01

TCGA−AA−3556−01 TCGA−AA−A01D−01 TCGA−AA−3542−01 TCGA−AA−A022−01 TCGA−AZ−5403−01 TCGA−DM−A28H−01 TCGA−AG−A01W−01 TCGA−CM−6164−01 TCGA−AA−3977−01 TCGA−AA−A01Q−01 TCGA−AG−3584−01 TCGA−G4−6625−01 TCGA−F5−6813−01 TCGA−AZ−6599−01 TCGA−CM−5862−01 TCGA−G4−6628−01 TCGA−A6−2676−01 TCGA−DY−A1DD−01 TCGA−CM−6165−01 TCGA−AA−3679−01 TCGA−DY−A1DG−01 TCGA−DM−A1HA−01 TCGA−AA−3844−01 TCGA−AA−3510−01 TCGA−D5−6927−01 TCGA−AA−3672−01 TCGA−AA−3864−01 TCGA−AF−6136−01 TCGA−AA−3947−01 TCGA−G4−6588−01 TCGA−A6−5661−01 TCGA−A6−6653−01 TCGA−D5−6538−01 TCGA−D5−6535−01 TCGA−AA−3558−01 TCGA−A6−5662−01 TCGA−CM−6162−01 TCGA−AD−5900−01 TCGA−CK−4952−01 TCGA−D5−6537−01 TCGA−D5−5541−01 TCGA−AD−6548−01 TCGA−AA−3950−01 TCGA−CA−6717−01 TCGA−AZ−4315−01 TCGA−AA−A00N−01 TCGA−A6−6780−01 TCGA−F5−6465−01 TCGA−CM−6674−01 TCGA−AG−A025−01 TCGA−AA−A00A−01 TCGA−AA−3858−01 TCGA−AA−3837−01 TCGA−CK−6746−01 TCGA−AY−6196−01 TCGA−F4−6855−01 TCGA−DY−A0XA−01 TCGA−D5−6539−01 TCGA−D5−6536−01 TCGA−CK−6748−01 TCGA−AZ−6600−01 TCGA−AD−6889−01 TCGA−AA−3712−01 TCGA−AA−3696−01 TCGA−A6−6138−01 TCGA−AD−6964−01 TCGA−F4−6856−01 TCGA−F4−6703−01 TCGA−DY−A1DF−01 TCGA−DM−A1D9−01 TCGA−CK−5913−01 TCGA−AG−A02N−01 TCGA−AA−A01R−01 TCGA−AA−A00J−01 TCGA−AA−3815−01 TCGA−F5−6571−01 TCGA−D5−6931−01 TCGA−D5−5540−01 TCGA−CM−6171−01 TCGA−CM−4746−01 TCGA−AA−A03F−01 TCGA−AA−A00U−01 TCGA−A6−2677−01 TCGA−AA−3492−01 TCGA−CK−5916−01 TCGA−D5−6923−01 TCGA−CM−5349−01 TCGA−CM−5348−01 TCGA−CM−4743−01 TCGA−AZ−5407−01 TCGA−AU−3779−01 TCGA−AD−6895−01 TCGA−AA−3713−01 TCGA−A6−5665−01 TCGA−G4−6626−01 TCGA−G4−6315−01 TCGA−G4−6310−01 TCGA−G4−6293−01 TCGA−DM−A0XF−01 TCGA−DC−5337−01 TCGA−D5−6533−01 TCGA−D5−5539−01 TCGA−D5−5537−01 TCGA−CM−5344−01 TCGA−CK−5915−01 TCGA−CK−4950−01 TCGA−CI−6624−01 TCGA−CA−6719−01 TCGA−AA−3662−01 TCGA−AA−3660−01 TCGA−AA−3496−01 TCGA−AG−A002−01 TCGA−AY−6197−01 TCGA−AA−A010−01 TCGA−AY−5543−01 TCGA−AA−3715−01 TCGA−AZ−6601−01 TCGA−AZ−6598−01 TCGA−AU−6004−01 TCGA−AA−3984−01 TCGA−AA−3877−01 TCGA−G4−6586−01 TCGA−F4−6570−01 TCGA−DT−5265−01 TCGA−DM−A282−01 TCGA−CM−4752−01 TCGA−A6−6781−01 TCGA−A6−4105−01 TCGA−G4−6309−01 TCGA−G4−6307−01 TCGA−F4−6806−01 TCGA−EF−5830−01 TCGA−DM−A28K−01 TCGA−DM−A1D4−01 TCGA−CA−6716−01 TCGA−AG−3892−01 TCGA−AA−A00K−01 TCGA−AA−3980−01 TCGA−AA−3956−01 TCGA−AA−3949−01 TCGA−AA−3867−01 TCGA−AA−3854−01 TCGA−AA−3821−01 TCGA−AA−3710−01 TCGA−AA−3666−01 TCGA−AA−3663−01 TCGA−AA−3555−01 TCGA−A6−6651−01 TCGA−A6−6141−01 TCGA−A6−5666−01

Hypoxia Response Via HIF Activation FDR = 1.9e−12%, FDR nod = 3.7e−09% HIF 2 Alpha Transcription Factor Network FDR = 2e−04%, FDR nod = 0.2%

EIF3E

TCGA−D5−6931−01 TCGA−AA−A01Q−01 TCGA−AA−3527−01 TCGA−AA−3525−01 TCGA−AA−3492−01 TCGA−AG−A00Y−01 TCGA−AA−3851−01 TCGA−AA−A00L−01 TCGA−AA−A00A−01 TCGA−AA−A01R−01 TCGA−AA−3542−01 TCGA−CM−6674−01 TCGA−CK−5916−01 TCGA−AA−A02K−01 TCGA−AA−3710−01 TCGA−A6−6141−01 TCGA−CM−4752−01 TCGA−AA−A00K−01 TCGA−AA−3980−01 TCGA−AA−3956−01 TCGA−AA−3949−01 TCGA−AA−3867−01 TCGA−AA−3854−01 TCGA−AA−3821−01 TCGA−AA−3666−01 TCGA−AA−3555−01 TCGA−A6−4105−01 TCGA−G4−6310−01 TCGA−DM−A1D4−01 TCGA−AF−6655−01 TCGA−A6−6653−01 TCGA−G5−6641−01 TCGA−G4−6321−01 TCGA−DY−A1DD−01 TCGA−DC−6681−01 TCGA−D5−5540−01 TCGA−CM−6163−01 TCGA−CM−6161−01 TCGA−CI−6624−01 TCGA−AA−3861−01 TCGA−AA−3697−01 TCGA−CA−6717−01 TCGA−AA−3715−01 TCGA−AA−3984−01 TCGA−AA−3516−01 TCGA−F5−6812−01 TCGA−EI−6507−01 TCGA−D5−5537−01 TCGA−AD−6964−01 TCGA−AA−A00E−01 TCGA−AA−3947−01 TCGA−AA−3877−01 TCGA−AA−3672−01 TCGA−AA−3518−01 TCGA−AA−3510−01 TCGA−A6−5665−01 TCGA−G4−6304−01 TCGA−F4−6460−01 TCGA−DM−A28H−01 TCGA−DM−A1D7−01 TCGA−D5−5538−01 TCGA−AU−3779−01 TCGA−AH−6643−01 TCGA−AH−6544−01 TCGA−AG−A02N−01 TCGA−AG−3731−01 TCGA−AD−6963−01 TCGA−AA−A029−01 TCGA−AA−A022−01 TCGA−AA−3973−01 TCGA−AA−3966−01 TCGA−AA−3818−01 TCGA−AA−3811−01 TCGA−AA−3662−01 TCGA−AG−A002−01 TCGA−AU−6004−01 TCGA−AA−A010−01 TCGA−AZ−6598−01 TCGA−AZ−4315−01 TCGA−AA−3815−01 TCGA−G4−6628−01 TCGA−G4−6586−01 TCGA−D5−6923−01 TCGA−D5−6535−01 TCGA−CM−6171−01 TCGA−CA−6718−01 TCGA−AY−6197−01 TCGA−AY−5543−01 TCGA−AA−3977−01 TCGA−AA−3663−01 TCGA−G4−6588−01 TCGA−G4−6307−01 TCGA−G4−6293−01 TCGA−F4−6808−01 TCGA−F4−6570−01 TCGA−EI−6510−01 TCGA−EF−5830−01 TCGA−D5−6540−01 TCGA−CM−6678−01 TCGA−CM−6168−01 TCGA−CM−6164−01 TCGA−CM−5864−01 TCGA−CM−5861−01 TCGA−CM−5349−01 TCGA−CM−5348−01 TCGA−CM−5344−01 TCGA−CK−6746−01 TCGA−CK−4948−01 TCGA−AZ−6605−01 TCGA−AZ−6601−01 TCGA−AZ−6599−01 TCGA−AH−6549−01 TCGA−AD−5900−01 TCGA−AA−3968−01 TCGA−A6−5666−01 TCGA−G4−6626−01 TCGA−G4−6625−01 TCGA−G4−6317−01 TCGA−G4−6315−01 TCGA−G4−6309−01 TCGA−F5−6811−01 TCGA−F5−6571−01 TCGA−F4−6856−01 TCGA−F4−6855−01 TCGA−F4−6807−01 TCGA−F4−6806−01 TCGA−DY−A1DG−01 TCGA−DY−A0XA−01 TCGA−DT−5265−01 TCGA−DM−A28K−01 TCGA−DM−A28G−01 TCGA−DM−A282−01 TCGA−DM−A1HA−01 TCGA−DM−A1DA−01 TCGA−DM−A1D8−01 TCGA−DC−6683−01 TCGA−DC−5337−01 TCGA−D5−6929−01 TCGA−D5−6928−01 TCGA−D5−6922−01 TCGA−D5−6537−01 TCGA−D5−6536−01 TCGA−D5−6533−01 TCGA−D5−6532−01 TCGA−CM−6680−01 TCGA−CM−6676−01 TCGA−CM−6170−01 TCGA−CM−6169−01 TCGA−CM−6166−01 TCGA−CM−5862−01 TCGA−CM−4746−01 TCGA−CM−4743−01 TCGA−CI−6620−01 TCGA−CA−6716−01 TCGA−CA−5255−01 TCGA−AZ−6608−01 TCGA−AZ−6603−01 TCGA−AZ−5403−01 TCGA−AG−3892−01 TCGA−AG−3732−01 TCGA−AF−6672−01 TCGA−AF−2693−01 TCGA−AD−6965−01 TCGA−AD−6889−01 TCGA−AA−3950−01 TCGA−AA−3864−01 TCGA−AA−3713−01 TCGA−AA−3655−01 TCGA−A6−6781−01 TCGA−A6−6651−01 TCGA−A6−5662−01 TCGA−A6−5661−01 TCGA−A6−5657−01 TCGA−A6−3809−01 TCGA−G5−6235−01 TCGA−G4−6323−01 TCGA−G4−6306−01 TCGA−G4−6303−01 TCGA−G4−6299−01 TCGA−F5−6813−01 TCGA−F5−6465−01 TCGA−F4−6854−01 TCGA−F4−6809−01 TCGA−F4−6805−01 TCGA−F4−6703−01 TCGA−F4−6569−01 TCGA−EI−6506−01 TCGA−DY−A1H8−01 TCGA−DY−A1DF−01 TCGA−DM−A28F−01 TCGA−DM−A28E−01 TCGA−DM−A28C−01 TCGA−DM−A1DB−01 TCGA−DM−A1D6−01 TCGA−DM−A0XF−01 TCGA−DM−A0XD−01 TCGA−DM−A0X9−01 TCGA−DC−6160−01 TCGA−DC−6157−01 TCGA−D5−7000−01 TCGA−D5−6932−01 TCGA−D5−6927−01 TCGA−D5−6924−01 TCGA−D5−6898−01 TCGA−D5−6539−01 TCGA−D5−6538−01 TCGA−D5−6534−01 TCGA−D5−6529−01 TCGA−D5−5541−01 TCGA−D5−5539−01 TCGA−CM−6677−01 TCGA−CM−6675−01 TCGA−CM−6172−01 TCGA−CM−6167−01 TCGA−CM−6165−01 TCGA−CM−6162−01 TCGA−CM−5868−01 TCGA−CM−5860−01 TCGA−CM−4747−01 TCGA−CL−5917−01 TCGA−CK−6748−01 TCGA−CK−6747−01 TCGA−CK−5915−01 TCGA−CK−5914−01 TCGA−CK−5913−01 TCGA−CK−5912−01 TCGA−CK−4952−01 TCGA−CK−4950−01 TCGA−CK−4947−01 TCGA−CI−6622−01 TCGA−CI−6619−01 TCGA−CA−5796−01 TCGA−CA−5254−01 TCGA−AZ−6606−01 TCGA−AZ−5407−01 TCGA−AZ−4682−01 TCGA−AZ−4616−01 TCGA−AY−6386−01 TCGA−AH−6547−01 TCGA−AG−3901−01 TCGA−AG−3885−01 TCGA−AF−6136−01 TCGA−AF−5654−01 TCGA−AF−2687−01 TCGA−AD−6901−01 TCGA−AD−6895−01 TCGA−AD−6888−01 TCGA−AA−3712−01 TCGA−AA−3692−01 TCGA−AA−3660−01 TCGA−AA−3502−01 TCGA−AA−3496−01 TCGA−A6−6780−01 TCGA−A6−6652−01 TCGA−A6−6649−01 TCGA−A6−6648−01 TCGA−A6−5664−01 TCGA−A6−5660−01 TCGA−A6−5659−01 TCGA−A6−5656−01 TCGA−A6−2671−01

TCGA−F4−6809−01 TCGA−A6−2671−01 TCGA−AA−A01P−01 TCGA−AA−A02K−01 TCGA−F4−6856−01 TCGA−AA−A00L−01 TCGA−AA−3492−01 TCGA−CM−6674−01 TCGA−AA−3833−01 TCGA−AA−3525−01 TCGA−DT−5265−01 TCGA−AA−3664−01 TCGA−D5−6928−01 TCGA−A6−5661−01 TCGA−AG−3598−01 TCGA−AA−3975−01 TCGA−AG−3583−01 TCGA−AA−3710−01 TCGA−AA−A00A−01 TCGA−CL−5918−01 TCGA−AG−3892−01 TCGA−DM−A28K−01 TCGA−CM−6679−01 TCGA−AG−3575−01 TCGA−AA−3712−01 TCGA−CM−4746−01 TCGA−DM−A0XD−01 TCGA−AA−3531−01 TCGA−A6−6142−01 TCGA−AZ−6598−01 TCGA−AD−6895−01 TCGA−DM−A28F−01 TCGA−DM−A1D9−01 TCGA−D5−6932−01 TCGA−CK−5915−01 TCGA−AA−3489−01 TCGA−AA−3977−01 TCGA−CA−6718−01 TCGA−AA−3949−01 TCGA−F4−6703−01 TCGA−CM−5860−01 TCGA−AF−5654−01 TCGA−AF−4110−01 TCGA−AA−3950−01 TCGA−F4−6854−01 TCGA−DM−A28E−01 TCGA−CA−5797−01 TCGA−AG−3878−01 TCGA−AF−6136−01 TCGA−AA−A01Q−01 TCGA−AA−A00N−01 TCGA−CK−5913−01 TCGA−AA−A00J−01 TCGA−A6−6780−01 TCGA−D5−6931−01 TCGA−D5−6539−01 TCGA−CM−4752−01 TCGA−CI−6619−01 TCGA−AD−6889−01 TCGA−AA−A00R−01 TCGA−AA−3555−01 TCGA−AA−3527−01 TCGA−A6−6141−01 TCGA−G5−6235−01 TCGA−G4−6323−01 TCGA−F5−6813−01 TCGA−DM−A1D0−01 TCGA−DC−6682−01 TCGA−CM−6162−01 TCGA−CM−5868−01 TCGA−CA−5796−01 TCGA−AY−6386−01 TCGA−AF−2687−01 TCGA−AA−A01G−01 TCGA−AA−3554−01 TCGA−A6−6781−01 TCGA−A6−5659−01 TCGA−CA−6717−01 TCGA−AZ−4315−01 TCGA−AA−A010−01 TCGA−AA−3864−01 TCGA−AA−3815−01 TCGA−AA−3672−01 TCGA−G4−6588−01 TCGA−EI−6507−01 TCGA−AZ−6601−01 TCGA−AA−3984−01 TCGA−AA−3715−01 TCGA−G4−6586−01 TCGA−CM−4743−01 TCGA−AU−3779−01 TCGA−AA−A022−01 TCGA−AA−3966−01 TCGA−AA−3877−01 TCGA−DM−A1DA−01 TCGA−AG−A02N−01 TCGA−AA−A00E−01 TCGA−AA−3947−01 TCGA−AA−3811−01 TCGA−AA−3662−01 TCGA−G4−6625−01 TCGA−G4−6307−01 TCGA−G4−6304−01 TCGA−F4−6808−01 TCGA−F4−6460−01 TCGA−DM−A28H−01 TCGA−DM−A1HA−01 TCGA−DM−A1D8−01 TCGA−DM−A1D7−01 TCGA−D5−5538−01 TCGA−D5−5537−01 TCGA−CM−6680−01 TCGA−CI−6620−01 TCGA−AH−6643−01 TCGA−AH−6544−01 TCGA−AG−3731−01 TCGA−AD−6963−01 TCGA−AA−A029−01 TCGA−AA−3973−01 TCGA−AA−3818−01 TCGA−AA−3713−01 TCGA−AA−3518−01 TCGA−AA−3516−01 TCGA−AA−3510−01 TCGA−AG−A002−01 TCGA−G4−6628−01 TCGA−AY−6197−01 TCGA−D5−6540−01 TCGA−AD−5900−01 TCGA−DY−A0XA−01 TCGA−CK−6746−01 TCGA−AU−6004−01 TCGA−AD−6964−01 TCGA−AA−3663−01 TCGA−G4−6293−01 TCGA−EI−6510−01 TCGA−CM−6171−01 TCGA−CM−6168−01 TCGA−CI−6624−01 TCGA−AZ−6599−01 TCGA−AG−3732−01 TCGA−AD−6965−01 TCGA−A6−6653−01 TCGA−A6−5665−01 TCGA−G5−6641−01 TCGA−G4−6321−01 TCGA−G4−6315−01 TCGA−G4−6310−01 TCGA−F5−6812−01 TCGA−F4−6570−01 TCGA−EF−5830−01 TCGA−DY−A1DD−01 TCGA−D5−6929−01 TCGA−D5−6923−01 TCGA−D5−6535−01 TCGA−D5−5540−01 TCGA−CM−6164−01 TCGA−CM−6161−01 TCGA−CM−5862−01 TCGA−CM−5861−01 TCGA−CM−5349−01 TCGA−CM−5344−01 TCGA−CK−4948−01 TCGA−AZ−6605−01 TCGA−AZ−5403−01 TCGA−AY−5543−01 TCGA−AH−6549−01 TCGA−AA−3697−01 TCGA−AA−3655−01 TCGA−A6−5662−01 TCGA−A6−4105−01 TCGA−G4−6626−01 TCGA−F5−6811−01 TCGA−F4−6855−01 TCGA−F4−6807−01 TCGA−DM−A28G−01 TCGA−DM−A1D4−01 TCGA−DC−6683−01 TCGA−DC−6681−01 TCGA−DC−5337−01 TCGA−D5−6922−01 TCGA−D5−6537−01 TCGA−D5−6536−01 TCGA−D5−6533−01 TCGA−D5−6532−01 TCGA−CM−6678−01 TCGA−CM−6676−01 TCGA−CM−6170−01 TCGA−CM−6169−01 TCGA−CM−6163−01 TCGA−CM−5864−01 TCGA−CM−5348−01 TCGA−CA−5255−01 TCGA−AZ−6608−01 TCGA−AZ−6603−01 TCGA−AF−6672−01 TCGA−AF−6655−01 TCGA−AF−2693−01 TCGA−AA−3968−01 TCGA−AA−3861−01 TCGA−A6−5666−01 TCGA−A6−5657−01

TCGA−AA−A00J−01 TCGA−CK−6751−01 TCGA−AA−3529−01 TCGA−AA−3554−01 TCGA−AZ−6600−01 TCGA−A6−6653−01 TCGA−AA−A01P−01 TCGA−AA−3869−01 TCGA−AA−A00E−01 TCGA−AY−4070−01 TCGA−AA−3845−01 TCGA−AA−3941−01 TCGA−AA−3666−01 TCGA−AA−3518−01 TCGA−AG−3882−01 TCGA−AA−3821−01 TCGA−AA−3562−01 TCGA−A6−6138−01 TCGA−G4−6321−01 TCGA−AA−3966−01 TCGA−AA−3710−01 TCGA−AY−6196−01 TCGA−AA−3833−01 TCGA−F5−6812−01 TCGA−AA−A02J−01 TCGA−AA−3530−01 TCGA−AA−3984−01 TCGA−AA−3525−01 TCGA−AA−3516−01 TCGA−D5−6930−01 TCGA−AA−A01R−01 TCGA−AA−A00A−01 TCGA−AA−3679−01 TCGA−AA−3672−01 TCGA−AA−3543−01 TCGA−AA−A022−01 TCGA−A6−2676−01 TCGA−DY−A1DD−01 TCGA−CM−5863−01 TCGA−AG−4007−01 TCGA−AA−A01Q−01 TCGA−AA−A00R−01 TCGA−AA−3979−01 TCGA−AA−3811−01 TCGA−A6−2672−01 TCGA−AG−A002−01 TCGA−AD−6895−01 TCGA−AD−6889−01 TCGA−G4−6626−01 TCGA−D5−6924−01 TCGA−D5−6535−01 TCGA−D5−6533−01 TCGA−G4−6309−01 TCGA−G4−6306−01 TCGA−F4−6703−01 TCGA−EI−6506−01 TCGA−DY−A1H8−01 TCGA−DM−A28K−01 TCGA−DC−5337−01 TCGA−D5−6928−01 TCGA−D5−6539−01 TCGA−CM−6170−01 TCGA−CM−5868−01 TCGA−CK−6748−01 TCGA−CK−5913−01 TCGA−CI−6620−01 TCGA−CA−6716−01 TCGA−CA−5255−01 TCGA−AG−3892−01 TCGA−AD−6901−01 TCGA−A6−6781−01 TCGA−A6−6648−01 TCGA−F5−6465−01 TCGA−F4−6806−01 TCGA−EI−6510−01 TCGA−DY−A1DF−01 TCGA−DM−A28F−01 TCGA−DM−A28E−01 TCGA−DM−A282−01 TCGA−DM−A1DA−01 TCGA−DM−A1D6−01 TCGA−D5−6932−01 TCGA−D5−6922−01 TCGA−CM−6677−01 TCGA−CM−6675−01 TCGA−CM−6167−01 TCGA−CM−6165−01 TCGA−CM−5348−01 TCGA−CK−5915−01 TCGA−CA−5796−01 TCGA−CA−5254−01 TCGA−AZ−6605−01 TCGA−AZ−6603−01 TCGA−AH−6549−01 TCGA−AH−6547−01 TCGA−AG−3885−01 TCGA−AG−3732−01 TCGA−AF−5654−01 TCGA−AD−6888−01 TCGA−AA−3968−01 TCGA−AA−3692−01 TCGA−AA−3502−01 TCGA−A6−6651−01 TCGA−A6−5664−01 TCGA−A6−2671−01 TCGA−AA−A010−01 TCGA−AG−A02N−01 TCGA−AA−3663−01 TCGA−G4−6588−01 TCGA−CM−4746−01 TCGA−CK−6746−01 TCGA−CK−4952−01 TCGA−CA−6717−01 TCGA−AZ−4315−01 TCGA−AZ−6601−01 TCGA−AZ−6598−01 TCGA−AY−6197−01 TCGA−F4−6570−01 TCGA−CM−5861−01 TCGA−CM−5860−01 TCGA−CA−6718−01 TCGA−AA−A00N−01 TCGA−AA−3815−01 TCGA−AA−3713−01 TCGA−AA−3492−01 TCGA−G4−6628−01 TCGA−G4−6307−01 TCGA−DM−A1DB−01 TCGA−D5−6540−01 TCGA−CM−6171−01 TCGA−CM−6162−01 TCGA−CM−5349−01 TCGA−CM−4743−01 TCGA−CK−5916−01 TCGA−AZ−6599−01 TCGA−AZ−5407−01 TCGA−AU−6004−01 TCGA−AD−5900−01 TCGA−AA−3977−01 TCGA−AA−3950−01 TCGA−AA−3864−01 TCGA−A6−5661−01 TCGA−G4−6586−01 TCGA−G4−6317−01 TCGA−G4−6315−01 TCGA−G4−6304−01 TCGA−G4−6299−01 TCGA−F4−6856−01 TCGA−F4−6855−01 TCGA−EI−6507−01 TCGA−DY−A1DG−01 TCGA−DY−A0XA−01 TCGA−DM−A285−01 TCGA−DM−A0XD−01 TCGA−D5−6929−01 TCGA−D5−6923−01 TCGA−D5−6538−01 TCGA−D5−6537−01 TCGA−D5−6536−01 TCGA−D5−5541−01 TCGA−D5−5539−01 TCGA−CM−6172−01 TCGA−CM−6168−01 TCGA−CM−5862−01 TCGA−AZ−6608−01 TCGA−AZ−6606−01 TCGA−AY−6386−01 TCGA−AY−5543−01 TCGA−AF−2693−01 TCGA−AD−6965−01 TCGA−AA−3947−01 TCGA−AA−3715−01 TCGA−AA−3712−01 TCGA−AA−3696−01 TCGA−A6−6780−01 TCGA−A6−6649−01 TCGA−A6−5665−01 TCGA−A6−5659−01 TCGA−A6−5657−01 TCGA−G5−6235−01 TCGA−G4−6625−01 TCGA−G4−6323−01 TCGA−G4−6310−01 TCGA−G4−6303−01 TCGA−G4−6293−01 TCGA−F5−6813−01 TCGA−F5−6811−01 TCGA−F5−6571−01 TCGA−F4−6854−01 TCGA−F4−6809−01 TCGA−F4−6808−01 TCGA−F4−6807−01 TCGA−F4−6805−01 TCGA−F4−6569−01 TCGA−F4−6460−01 TCGA−F4−6459−01 TCGA−EF−5830−01 TCGA−DT−5265−01 TCGA−DM−A28H−01 TCGA−DM−A28G−01 TCGA−DM−A28C−01 TCGA−DM−A1HA−01 TCGA−DM−A1D8−01 TCGA−DM−A0XF−01 TCGA−DM−A0X9−01 TCGA−DC−6683−01 TCGA−DC−6160−01 TCGA−DC−6157−01 TCGA−D5−7000−01 TCGA−D5−6927−01 TCGA−D5−6920−01 TCGA−D5−6898−01 TCGA−D5−6534−01 TCGA−D5−6532−01 TCGA−D5−6529−01 TCGA−CM−6680−01 TCGA−CM−6678−01 TCGA−CM−6676−01 TCGA−CM−6169−01 TCGA−CM−6166−01 TCGA−CM−6164−01 TCGA−CM−5864−01 TCGA−CM−5344−01 TCGA−CM−4752−01 TCGA−CM−4747−01 TCGA−CL−5917−01 TCGA−CK−6747−01 TCGA−CK−5914−01 TCGA−CK−5912−01 TCGA−CK−4950−01 TCGA−CK−4948−01 TCGA−CK−4947−01 TCGA−CI−6622−01 TCGA−CI−6619−01 TCGA−AZ−5403−01 TCGA−AZ−4682−01 TCGA−AZ−4616−01 TCGA−AU−3779−01 TCGA−AH−6644−01 TCGA−AH−6643−01 TCGA−AH−6544−01 TCGA−AG−3901−01 TCGA−AG−3731−01 TCGA−AF−6672−01 TCGA−AF−6136−01 TCGA−AF−2687−01 TCGA−AD−6548−01 TCGA−AA−3848−01 TCGA−AA−3818−01 TCGA−AA−3660−01 TCGA−AA−3655−01 TCGA−AA−3510−01 TCGA−AA−3496−01 TCGA−A6−6782−01 TCGA−A6−6652−01 TCGA−A6−5666−01 TCGA−A6−5662−01 TCGA−A6−5660−01 TCGA−A6−5656−01 TCGA−A6−3809−01 TCGA−A6−3808−01 TCGA−DY−A1DC−01 TCGA−DM−A1D9−01 TCGA−DM−A1D7−01 TCGA−DC−6682−01 TCGA−DC−6158−01 TCGA−DC−5869−01 TCGA−D5−6931−01 TCGA−D5−6926−01 TCGA−D5−6541−01 TCGA−D5−5540−01 TCGA−D5−5538−01 TCGA−CM−6674−01 TCGA−CM−6161−01 TCGA−CL−5918−01 TCGA−CI−6624−01 TCGA−CA−6719−01 TCGA−AG−A020−01 TCGA−AG−A00H−01 TCGA−AG−4015−01 TCGA−AG−3887−01 TCGA−AG−3878−01 TCGA−AG−3742−01 TCGA−AD−6964−01 TCGA−AD−6963−01 TCGA−AD−6899−01 TCGA−AD−6890−01 TCGA−AA−A03J−01 TCGA−AA−A03F−01 TCGA−AA−A02Y−01 TCGA−AA−A02O−01 TCGA−AA−A01V−01 TCGA−AA−A01K−01 TCGA−AA−A01I−01 TCGA−AA−3956−01 TCGA−AA−3939−01 TCGA−AA−3877−01 TCGA−AA−3866−01 TCGA−AA−3852−01 TCGA−AA−3850−01 TCGA−AA−3837−01 TCGA−AA−3812−01 TCGA−AA−3697−01 TCGA−AA−3673−01 TCGA−AA−3662−01 TCGA−AA−3511−01 TCGA−AA−3489−01 TCGA−A6−6654−01 TCGA−A6−6141−01 TCGA−A6−4105−01

TCGA−AG−3887−01 TCGA−AA−3518−01 TCGA−AA−3510−01 TCGA−AA−A01P−01 TCGA−AA−3527−01 TCGA−AA−3710−01 TCGA−A6−6781−01 TCGA−AA−3947−01 TCGA−AA−3525−01 TCGA−AA−A00A−01 TCGA−AA−3672−01 TCGA−CM−6674−01 TCGA−AA−A02K−01 TCGA−AA−3950−01 TCGA−A6−3809−01 TCGA−G4−6588−01 TCGA−AA−A022−01 TCGA−AZ−6606−01 TCGA−AA−A00N−01 TCGA−AA−3877−01 TCGA−AZ−4315−01 TCGA−D5−6928−01 TCGA−AD−6889−01 TCGA−AA−A01Q−01 TCGA−AA−3966−01 TCGA−AA−3555−01 TCGA−AG−A002−01 TCGA−A6−6653−01 TCGA−CM−5861−01 TCGA−CK−6746−01 TCGA−AD−6964−01 TCGA−G5−6641−01 TCGA−F5−6811−01 TCGA−F4−6855−01 TCGA−F4−6570−01 TCGA−DM−A28G−01 TCGA−DC−6681−01 TCGA−D5−6537−01 TCGA−D5−6536−01 TCGA−CM−6678−01 TCGA−CM−6170−01 TCGA−CM−5344−01 TCGA−CA−5255−01 TCGA−AZ−6603−01 TCGA−AH−6549−01 TCGA−AA−3968−01 TCGA−AA−3861−01 TCGA−A6−5666−01 TCGA−A6−5657−01 TCGA−G4−6628−01 TCGA−CA−6718−01 TCGA−AA−A010−01 TCGA−AZ−6598−01 TCGA−AU−6004−01 TCGA−AA−3663−01 TCGA−A6−4105−01 TCGA−G4−6310−01 TCGA−G4−6293−01 TCGA−D5−6535−01 TCGA−D5−6532−01 TCGA−D5−5540−01 TCGA−CM−6171−01 TCGA−CM−5349−01 TCGA−CI−6624−01 TCGA−CA−6717−01 TCGA−AZ−6605−01 TCGA−AY−6197−01 TCGA−AA−3815−01 TCGA−G4−6626−01 TCGA−G4−6321−01 TCGA−G4−6315−01 TCGA−F5−6812−01 TCGA−F4−6807−01 TCGA−EI−6510−01 TCGA−EF−5830−01 TCGA−DY−A1DD−01 TCGA−DY−A1DC−01 TCGA−DY−A0XA−01 TCGA−DM−A1D9−01 TCGA−DM−A1D4−01 TCGA−DC−6683−01 TCGA−DC−5337−01 TCGA−D5−6929−01 TCGA−D5−6923−01 TCGA−D5−6922−01 TCGA−D5−6540−01 TCGA−D5−6538−01 TCGA−D5−6533−01 TCGA−CM−6676−01 TCGA−CM−6169−01 TCGA−CM−6168−01 TCGA−CM−6164−01 TCGA−CM−6163−01 TCGA−CM−6161−01 TCGA−CM−5864−01 TCGA−CM−5862−01 TCGA−CM−5348−01 TCGA−CM−4752−01 TCGA−CM−4746−01 TCGA−CM−4743−01 TCGA−CK−5916−01 TCGA−CK−4948−01 TCGA−CI−6621−01 TCGA−AZ−6608−01 TCGA−AZ−6601−01 TCGA−AZ−6599−01 TCGA−AZ−5403−01 TCGA−AY−5543−01 TCGA−AG−3902−01 TCGA−AG−3732−01 TCGA−AF−6672−01 TCGA−AF−6655−01 TCGA−AF−6136−01 TCGA−AF−2693−01 TCGA−AD−6965−01 TCGA−AD−6901−01 TCGA−AD−5900−01 TCGA−AA−A00L−01 TCGA−AA−A00E−01 TCGA−AA−3949−01 TCGA−AA−3697−01 TCGA−AA−3660−01 TCGA−AA−3655−01 TCGA−A6−5665−01 TCGA−A6−5662−01 TCGA−A6−5659−01 TCGA−A6−2676−01 TCGA−G5−6235−01 TCGA−G4−6625−01 TCGA−G4−6586−01 TCGA−G4−6323−01 TCGA−G4−6317−01 TCGA−G4−6307−01 TCGA−G4−6306−01 TCGA−G4−6304−01 TCGA−G4−6303−01 TCGA−G4−6299−01 TCGA−F5−6813−01 TCGA−F5−6702−01 TCGA−F5−6571−01 TCGA−F5−6464−01 TCGA−F4−6856−01 TCGA−F4−6854−01 TCGA−F4−6808−01 TCGA−F4−6806−01 TCGA−F4−6805−01 TCGA−F4−6704−01 TCGA−F4−6703−01 TCGA−F4−6460−01 TCGA−F4−6459−01 TCGA−EI−6508−01 TCGA−EI−6507−01 TCGA−EI−6506−01 TCGA−DY−A1DG−01 TCGA−DY−A1DF−01 TCGA−DT−5265−01 TCGA−DM−A28K−01 TCGA−DM−A28H−01 TCGA−DM−A28F−01 TCGA−DM−A28E−01 TCGA−DM−A285−01 TCGA−DM−A1HA−01 TCGA−DM−A1DB−01 TCGA−DM−A1DA−01 TCGA−DM−A1D8−01 TCGA−DM−A1D7−01 TCGA−DM−A1D6−01 TCGA−DM−A1D0−01 TCGA−DM−A0XF−01 TCGA−DM−A0XD−01 TCGA−DC−6682−01 TCGA−DC−6158−01 TCGA−DC−6157−01 TCGA−DC−6155−01 TCGA−DC−5869−01 TCGA−D5−6932−01 TCGA−D5−6931−01 TCGA−D5−6930−01 TCGA−D5−6927−01 TCGA−D5−6926−01 TCGA−D5−6924−01 TCGA−D5−6920−01 TCGA−D5−6898−01 TCGA−D5−6541−01 TCGA−D5−6539−01 TCGA−D5−5541−01 TCGA−D5−5538−01 TCGA−CM−6679−01 TCGA−CM−6677−01 TCGA−CM−6675−01 TCGA−CM−6172−01 TCGA−CM−6166−01 TCGA−CM−6165−01 TCGA−CM−6162−01 TCGA−CM−5868−01 TCGA−CM−5860−01 TCGA−CM−5341−01 TCGA−CM−4744−01 TCGA−CL−5918−01 TCGA−CL−5917−01 TCGA−CK−5914−01 TCGA−CK−4952−01 TCGA−CK−4950−01 TCGA−CK−4947−01 TCGA−CI−6622−01 TCGA−CI−6620−01 TCGA−CI−6619−01 TCGA−CA−6719−01 TCGA−CA−6716−01 TCGA−CA−5797−01 TCGA−AZ−6607−01 TCGA−AZ−6600−01 TCGA−AZ−5407−01 TCGA−AZ−4616−01 TCGA−AZ−4323−01 TCGA−AY−6196−01 TCGA−AY−4071−01 TCGA−AY−4070−01 TCGA−AU−3779−01 TCGA−AH−6643−01 TCGA−AH−6544−01 TCGA−AG−A036−01 TCGA−AG−A032−01 TCGA−AG−A02X−01 TCGA−AG−A02N−01 TCGA−AG−A026−01 TCGA−AG−A020−01 TCGA−AG−A01Y−01 TCGA−AG−A01W−01 TCGA−AG−A01L−01 TCGA−AG−A016−01 TCGA−AG−A014−01 TCGA−AG−A011−01 TCGA−AG−A00Y−01 TCGA−AG−A00C−01 TCGA−AG−4015−01 TCGA−AG−4008−01 TCGA−AG−4007−01 TCGA−AG−4005−01 TCGA−AG−3999−01 TCGA−AG−3909−01 TCGA−AG−3898−01 TCGA−AG−3896−01 TCGA−AG−3893−01 TCGA−AG−3890−01 TCGA−AG−3885−01 TCGA−AG−3882−01 TCGA−AG−3742−01 TCGA−AG−3731−01 TCGA−AG−3726−01 TCGA−AG−3612−01 TCGA−AG−3611−01 TCGA−AG−3609−01 TCGA−AG−3608−01 TCGA−AG−3605−01 TCGA−AG−3602−01 TCGA−AG−3601−01 TCGA−AG−3598−01 TCGA−AG−3594−01 TCGA−AG−3587−01 TCGA−AG−3581−01 TCGA−AG−3578−01 TCGA−AG−3575−01 TCGA−AF−4110−01 TCGA−AF−3913−01 TCGA−AF−3400−01 TCGA−AF−2691−01 TCGA−AF−2689−01 TCGA−AF−2687−01 TCGA−AD−6963−01 TCGA−AD−6899−01 TCGA−AD−6888−01 TCGA−AD−6548−01 TCGA−AA−A03J−01 TCGA−AA−A02W−01 TCGA−AA−A02J−01 TCGA−AA−A02H−01 TCGA−AA−A02F−01 TCGA−AA−A01Z−01 TCGA−AA−A01T−01 TCGA−AA−A01S−01 TCGA−AA−A01K−01 TCGA−AA−A01G−01 TCGA−AA−A01F−01 TCGA−AA−A01D−01 TCGA−AA−A00W−01 TCGA−AA−A00F−01 TCGA−AA−A00D−01 TCGA−AA−3982−01 TCGA−AA−3980−01 TCGA−AA−3979−01 TCGA−AA−3977−01 TCGA−AA−3976−01 TCGA−AA−3975−01 TCGA−AA−3972−01 TCGA−AA−3956−01 TCGA−AA−3930−01 TCGA−AA−3875−01 TCGA−AA−3869−01 TCGA−AA−3867−01 TCGA−AA−3866−01 TCGA−AA−3860−01 TCGA−AA−3858−01 TCGA−AA−3856−01 TCGA−AA−3851−01 TCGA−AA−3848−01 TCGA−AA−3844−01 TCGA−AA−3842−01 TCGA−AA−3814−01 TCGA−AA−3811−01 TCGA−AA−3713−01 TCGA−AA−3712−01 TCGA−AA−3693−01 TCGA−AA−3685−01 TCGA−AA−3681−01 TCGA−AA−3679−01 TCGA−AA−3667−01 TCGA−AA−3666−01 TCGA−AA−3662−01 TCGA−AA−3562−01 TCGA−AA−3561−01 TCGA−AA−3560−01 TCGA−AA−3558−01 TCGA−AA−3556−01 TCGA−AA−3553−01 TCGA−AA−3552−01 TCGA−AA−3549−01 TCGA−AA−3542−01 TCGA−AA−3531−01 TCGA−AA−3526−01 TCGA−AA−3524−01 TCGA−AA−3520−01 TCGA−AA−3519−01 TCGA−AA−3517−01 TCGA−AA−3511−01 TCGA−AA−3492−01 TCGA−A6−6782−01 TCGA−A6−6654−01 TCGA−A6−6652−01 TCGA−A6−6651−01 TCGA−A6−6649−01 TCGA−A6−6142−01 TCGA−A6−6138−01 TCGA−A6−6137−01 TCGA−A6−5656−01 TCGA−A6−3810−01 TCGA−A6−3807−01 TCGA−A6−2683−01 TCGA−A6−2678−01 TCGA−A6−2674−01 TCGA−A6−2670−01

unknown CG mut MTOR

NAD+ + (S) Lactic Acid = NADH + Pyruvic Acid ( Glycolysis And Gluconeogenesis ) NAD+ + (S) Lactic Acid = NADH + Pyruvic Acid ( Pyruvate Metabolism ) NAD+ + 2 Hydroxy Butanoic Acid = NADH + 2 Oxo Butanoic Acid ( Propanoate Metabolism ) NAD+ + 3 Mercapto Lactic Acid = NADH + 3 Mercapto Pyruvic Acid ( Methionine And Cysteine Metabolism ) FDR = 0.65%, FDR nod = 0.97%

Leucine Stimulation On Insulin Signaling FDR = 0.003%, FDR nod = 0.0024%

LDHA

known HCG mut

wt IRS1

known HCG mut PIK3CG

MTOR ABCG2

AKT2 ADORA2A

ARNT ARNT

PARK2 EFNA1

HIF1AN

AKT1 TWIST1 CITED2

EGLN2 EGLN2

EGLN3 ELK1

GPR37 FXN

AKT3 PGK1

EGLN1 SERPINE1

TXN SLC11A2

TXN2 TCEB2

VEGFA

Insulin/IGF Pathway Protein Kinase B Signaling Cascade FDR = 1.9e−12%, FDR nod = 0.18% Hypoxic And Oxygen Homeostasis Regulation Of HIF 1 Alpha FDR = 1.9e−12%, FDR nod = 0.018%

unknown CG mut unknown CG mut TP53

PIK3CA VHL

PTEN

IGF2R HIF3A

INSRR EGLN2

IRS1 HSP90AA1

EGLN3

GSK3A HIF1AN

MDM2 NAA10

INPPL1 OS9

IGF1

MDM4 CDKN2A

IRS2 RACK1

PDPK1 RBX1

TCEB1

TSC1 TCEB2

TSC2

LDHB

TSC1

AKT1

PIK3R6

RHEB

LDHAL6B

IRS2

RPS6KB1

SLC7A5

LDHC

wt INSR wt ARNT


IRS4 CUL2

CREBBP FLT1

wt HIF1A wt SLC2A1

PTEN CREBBP

known HCG mut VHL known HCG mut KDR

unknown CG mut unknown CG mut VHL

EP300

ETS1

EPAS1 SP1

APEX1

BHLHE40

EGLN1

EGLN3 EPO

MMP14

POU5F1 SIRT1

TCEB1

IGF1R HIF1A

GSK3B

COPS5

EGLN1

FOXO1

FOXO3 IGF2

TSC2

unknown CG mut

INSR

wt

TCGA−AA−3814−01



TCGA−D5−6928−01

TCGA−D5−6529−01

TCGA−CM−5861−01

TCGA−CM−4746−01

TCGA−AD−5900−01

TCGA−AG−A002−01


TCGA−G4−6628−01

TCGA−DT−5265−01

TCGA−CA−6717−01

TCGA−AY−6386−01


TCGA−A6−6781−01

TCGA−G4−6293−01

TCGA−DM−A28K−01

TCGA−DC−6158−01

TCGA−D5−6540−01

TCGA−D5−6536−01

TCGA−CL−5918−01

TCGA−CL−5917−01

TCGA−CK−6748−01



TCGA−AG−3892−01

TCGA−AA−A01Q−01


TCGA−A6−2671−01

TCGA−AA−A01T−01 TCGA−G4−6293−01 TCGA−AY−6386−01 TCGA−AZ−4315−01 TCGA−CK−5913−01 TCGA−G4−6625−01 TCGA−F5−6813−01 TCGA−CM−5861−01 TCGA−DM−A1DA−01 TCGA−D5−6928−01 TCGA−AA−3815−01 TCGA−A6−6654−01 TCGA−D5−5537−01 TCGA−CM−6166−01 TCGA−CM−5864−01 TCGA−AZ−6605−01 TCGA−AA−3516−01 TCGA−CK−4952−01 TCGA−D5−6537−01 TCGA−D5−5541−01 TCGA−CM−6162−01 TCGA−AD−6548−01 TCGA−AA−A00N−01 TCGA−AA−A00J−01 TCGA−AA−3950−01 TCGA−AZ−6599−01 TCGA−AD−5900−01 TCGA−G4−6321−01 TCGA−G4−6304−01 TCGA−F4−6703−01 TCGA−DM−A1DB−01 TCGA−DM−A0XD−01 TCGA−D5−6924−01 TCGA−D5−5539−01 TCGA−AA−3848−01 TCGA−G4−6588−01 TCGA−CM−5860−01 TCGA−A6−5661−01 TCGA−G4−6628−01 TCGA−G4−6626−01 TCGA−DY−A1H8−01 TCGA−D5−6540−01 TCGA−CM−5862−01 TCGA−AY−4070−01 TCGA−AA−A00E−01 TCGA−AA−3845−01 TCGA−A6−5659−01 TCGA−AA−3492−01 TCGA−AG−A02N−01 TCGA−AD−6889−01 TCGA−A6−6138−01 TCGA−F4−6855−01 TCGA−DY−A0XA−01 TCGA−D5−6923−01 TCGA−D5−6539−01 TCGA−D5−6536−01 TCGA−CM−5349−01 TCGA−CK−6748−01 TCGA−AZ−6600−01 TCGA−AY−6196−01 TCGA−AA−3712−01 TCGA−AA−3696−01 TCGA−CM−4746−01 TCGA−CK−6746−01 TCGA−CA−6717−01 TCGA−D5−6533−01 TCGA−CA−6718−01 TCGA−AA−3977−01 TCGA−AA−3966−01 TCGA−AA−3947−01 TCGA−AA−3713−01 TCGA−A6−6653−01 TCGA−DC−6158−01 TCGA−D5−6534−01 TCGA−CM−6677−01 TCGA−CM−6674−01 TCGA−CM−5348−01 TCGA−CM−5341−01 TCGA−CK−5916−01 TCGA−CK−5915−01 TCGA−CI−6622−01 TCGA−AZ−6608−01 TCGA−AD−6901−01 TCGA−AA−3864−01 TCGA−AA−3833−01 TCGA−AA−3811−01 TCGA−AA−3660−01 TCGA−AA−3534−01 TCGA−AA−3525−01 TCGA−A6−2676−01 TCGA−AY−6197−01 TCGA−AG−A002−01 TCGA−AA−A010−01 TCGA−AZ−6598−01 TCGA−AA−3984−01 TCGA−AA−3877−01 TCGA−AA−3715−01 TCGA−G4−6586−01 TCGA−G4−6309−01 TCGA−CA−6716−01 TCGA−AU−6004−01 TCGA−AA−3949−01 TCGA−AA−3710−01 TCGA−AA−3663−01 TCGA−A6−6141−01 TCGA−G4−6307−01 TCGA−F4−6806−01 TCGA−F4−6570−01 TCGA−EF−5830−01 TCGA−DT−5265−01 TCGA−DM−A28K−01 TCGA−DM−A282−01 TCGA−DM−A1D4−01 TCGA−CM−4752−01 TCGA−AZ−6601−01 TCGA−AY−5543−01 TCGA−AG−3892−01 TCGA−AA−A00K−01 TCGA−AA−3980−01 TCGA−AA−3956−01 TCGA−AA−3867−01 TCGA−AA−3854−01 TCGA−AA−3821−01 TCGA−AA−3666−01 TCGA−AA−3555−01 TCGA−A6−6781−01 TCGA−A6−6651−01 TCGA−A6−5666−01 TCGA−A6−4105−01

DNA Damage/Telomere Stress Induced Senescence FDR = 1.9e−12%, FDR nod = 0.14% PTK6 Promotes HIF1A Stabilization FDR = 2e−12%, FDR nod = 2.6e−08%

TCGA−D5−6534−01 TCGA−AG−4001−01 TCGA−AA−3821−01 TCGA−AA−3715−01 TCGA−AA−3812−01 TCGA−AG−A025−01 TCGA−AD−6895−01 TCGA−AA−3994−01 TCGA−AA−A01V−01 TCGA−AG−A00H−01 TCGA−AA−A00R−01 TCGA−AA−A00J−01 TCGA−AA−3877−01 TCGA−AA−3947−01 TCGA−CM−5344−01 TCGA−AA−3845−01 TCGA−CM−6674−01 TCGA−CM−5863−01 TCGA−CK−5915−01 TCGA−AA−3554−01 TCGA−A6−3809−01 TCGA−AA−3672−01 TCGA−F5−6465−01 TCGA−AA−3864−01 TCGA−AA−3850−01 TCGA−AY−6386−01 TCGA−AG−A015−01 TCGA−AG−3599−01 TCGA−AA−A01Q−01 TCGA−A6−2672−01 TCGA−AG−A002−01 TCGA−CM−5861−01 TCGA−AG−3892−01 TCGA−AA−3516−01 TCGA−A6−5661−01 TCGA−CK−6746−01 TCGA−AA−A00N−01 TCGA−AA−3510−01 TCGA−G4−6588−01 TCGA−D5−6928−01 TCGA−AA−A01R−01 TCGA−AA−3984−01 TCGA−AA−3555−01 TCGA−F4−6809−01 TCGA−F4−6570−01 TCGA−DY−A1H8−01 TCGA−D5−7000−01 TCGA−D5−6536−01 TCGA−CM−6680−01 TCGA−CM−6170−01 TCGA−CK−5913−01 TCGA−AZ−6603−01 TCGA−AZ−4315−01 TCGA−AA−3710−01 TCGA−A6−6781−01 TCGA−A6−6653−01 TCGA−A6−6141−01 TCGA−G5−6641−01 TCGA−G4−6309−01 TCGA−DM−A28G−01 TCGA−DM−A28C−01 TCGA−D5−6537−01 TCGA−D5−6529−01 TCGA−D5−5539−01 TCGA−CK−6751−01 TCGA−CK−6748−01 TCGA−CK−5912−01 TCGA−CA−6715−01 TCGA−AZ−4682−01 TCGA−AG−3727−01 TCGA−AG−3600−01 TCGA−AD−6890−01 TCGA−AD−6889−01 TCGA−AA−A02Y−01 TCGA−AA−A022−01 TCGA−AA−3966−01 TCGA−AA−3950−01 TCGA−AA−3861−01 TCGA−AA−3819−01 TCGA−AA−3678−01 TCGA−AA−3664−01 TCGA−AA−3530−01 TCGA−AA−3527−01 TCGA−AA−3522−01 TCGA−AA−3518−01 TCGA−AA−3502−01 TCGA−AA−3496−01 TCGA−A6−6780−01 TCGA−A6−5664−01 TCGA−A6−5660−01 TCGA−AA−A010−01 TCGA−CA−6717−01 TCGA−AZ−6598−01 TCGA−D5−6540−01 TCGA−G4−6586−01 TCGA−EI−6507−01 TCGA−CK−4952−01 TCGA−CA−6718−01 TCGA−AZ−6599−01 TCGA−AA−3977−01 TCGA−AA−3713−01 TCGA−AA−3663−01 TCGA−AA−3492−01 TCGA−G4−6628−01 TCGA−G4−6306−01 TCGA−F4−6856−01 TCGA−DY−A1DF−01 TCGA−DM−A1DB−01 TCGA−CM−6171−01 TCGA−CM−6162−01 TCGA−CM−4743−01 TCGA−AU−6004−01 TCGA−AA−3811−01 TCGA−A6−5665−01 TCGA−G4−6304−01 TCGA−G4−6293−01 TCGA−EF−5830−01 TCGA−DM−A1D4−01 TCGA−D5−6930−01 TCGA−D5−6927−01 TCGA−D5−6898−01 TCGA−D5−6532−01 TCGA−CM−6677−01 TCGA−CM−6161−01 TCGA−CM−5862−01 TCGA−CM−5349−01 TCGA−CM−5348−01 TCGA−CM−4752−01 TCGA−CK−5916−01 TCGA−CK−5914−01 TCGA−CK−4947−01 TCGA−AZ−5407−01 TCGA−AY−6197−01 TCGA−AU−3779−01 TCGA−AH−6643−01 TCGA−AG−3731−01 TCGA−AF−4110−01 TCGA−AD−6963−01 TCGA−AD−5900−01 TCGA−AA−3860−01 TCGA−A6−4105−01 TCGA−G5−6235−01 TCGA−G4−6321−01 TCGA−G4−6317−01 TCGA−G4−6315−01 TCGA−G4−6307−01 TCGA−G4−6303−01 TCGA−F5−6813−01 TCGA−F5−6812−01 TCGA−F5−6702−01 TCGA−F4−6854−01 TCGA−F4−6808−01 TCGA−F4−6807−01 TCGA−F4−6806−01 TCGA−F4−6460−01 TCGA−EI−6508−01 TCGA−EI−6506−01 TCGA−DY−A1DC−01 TCGA−DT−5265−01 TCGA−DM−A28K−01 TCGA−DM−A28H−01 TCGA−DM−A28F−01 TCGA−DM−A28E−01 TCGA−DM−A1D8−01 TCGA−DM−A1D6−01 TCGA−DM−A0XF−01 TCGA−DM−A0XD−01 TCGA−DC−6683−01 TCGA−DC−6155−01 TCGA−DC−5337−01 TCGA−D5−6929−01 TCGA−D5−6924−01 TCGA−D5−6923−01 TCGA−D5−6920−01 TCGA−D5−6541−01 TCGA−D5−6539−01 TCGA−D5−6538−01 TCGA−D5−6535−01 TCGA−D5−6533−01 TCGA−D5−5538−01 TCGA−CM−6679−01 TCGA−CM−6172−01 TCGA−CM−6164−01 TCGA−CM−5868−01 TCGA−CM−5864−01 TCGA−CM−5860−01 TCGA−CM−5341−01 TCGA−CM−4746−01 TCGA−CM−4744−01 TCGA−CL−5917−01 TCGA−CK−4950−01 TCGA−CI−6624−01 TCGA−CI−6619−01 TCGA−CA−6719−01 TCGA−AZ−6608−01 TCGA−AZ−6601−01 TCGA−AZ−6600−01 TCGA−AZ−5403−01 TCGA−AZ−4323−01 TCGA−AY−6196−01 TCGA−AY−5543−01 TCGA−AH−6544−01 TCGA−AG−A016−01 TCGA−AG−3885−01 TCGA−AG−3742−01 TCGA−AG−3732−01 TCGA−AF−6655−01 TCGA−AF−2693−01 TCGA−AF−2687−01 TCGA−AD−6901−01 TCGA−AD−6899−01 TCGA−AD−6888−01 TCGA−AD−6548−01 TCGA−AA−A01T−01 TCGA−AA−A00E−01 TCGA−AA−3949−01 TCGA−AA−3815−01 TCGA−AA−3712−01 TCGA−AA−3697−01 TCGA−AA−3693−01 TCGA−AA−3685−01 TCGA−AA−3679−01 TCGA−AA−3667−01 TCGA−AA−3662−01 TCGA−AA−3660−01 TCGA−AA−3655−01 TCGA−AA−3552−01 TCGA−AA−3511−01 TCGA−A6−6142−01 TCGA−A6−6138−01 TCGA−A6−5659−01 TCGA−A6−3807−01 TCGA−A6−2676−01 TCGA−G4−6626−01 TCGA−G4−6625−01 TCGA−G4−6323−01 TCGA−G4−6310−01 TCGA−G4−6299−01 TCGA−F5−6571−01 TCGA−F5−6464−01 TCGA−F4−6805−01 TCGA−F4−6704−01 TCGA−F4−6703−01 TCGA−F4−6459−01 TCGA−EI−6510−01 TCGA−DY−A1DG−01 TCGA−DY−A1DD−01 TCGA−DY−A0XA−01 TCGA−DM−A285−01 TCGA−DM−A1HA−01 TCGA−DM−A1DA−01 TCGA−DM−A1D9−01 TCGA−DM−A1D7−01 TCGA−DM−A1D0−01 TCGA−DC−6682−01 TCGA−DC−6158−01 TCGA−DC−6157−01 TCGA−DC−5869−01 TCGA−D5−6932−01 TCGA−D5−6931−01 TCGA−D5−6926−01 TCGA−D5−6922−01 TCGA−D5−5541−01 TCGA−D5−5540−01 TCGA−CM−6676−01 TCGA−CM−6675−01 TCGA−CM−6169−01 TCGA−CM−6168−01 TCGA−CM−6166−01 TCGA−CM−6165−01 TCGA−CM−6163−01 TCGA−CL−5918−01 TCGA−CK−4948−01 TCGA−CI−6622−01 TCGA−CI−6621−01 TCGA−CI−6620−01 TCGA−CA−6716−01 TCGA−CA−5797−01 TCGA−AZ−6607−01 TCGA−AZ−6605−01 TCGA−AZ−4616−01 TCGA−AY−4071−01 TCGA−AY−4070−01 TCGA−AG−A036−01 TCGA−AG−A032−01 TCGA−AG−A02X−01 TCGA−AG−A02N−01 TCGA−AG−A026−01 TCGA−AG−A020−01 TCGA−AG−A01Y−01 TCGA−AG−A01W−01 TCGA−AG−A01L−01 TCGA−AG−A014−01 TCGA−AG−A011−01 TCGA−AG−A00Y−01 TCGA−AG−A00C−01 TCGA−AG−4015−01 TCGA−AG−4008−01 TCGA−AG−4007−01 TCGA−AG−4005−01 TCGA−AG−3999−01 TCGA−AG−3909−01 TCGA−AG−3902−01 TCGA−AG−3898−01 TCGA−AG−3896−01 TCGA−AG−3893−01 TCGA−AG−3890−01 TCGA−AG−3882−01 TCGA−AG−3726−01 TCGA−AG−3612−01 TCGA−AG−3611−01 TCGA−AG−3609−01 TCGA−AG−3608−01 TCGA−AG−3605−01 TCGA−AG−3602−01 TCGA−AG−3601−01 TCGA−AG−3598−01 TCGA−AG−3594−01 TCGA−AG−3587−01 TCGA−AG−3581−01 TCGA−AG−3578−01 TCGA−AG−3575−01 TCGA−AF−6672−01 TCGA−AF−6136−01 TCGA−AF−3913−01 TCGA−AF−3400−01 TCGA−AF−2691−01 TCGA−AF−2689−01 TCGA−AD−6965−01 TCGA−AA−A03J−01 TCGA−AA−A02W−01 TCGA−AA−A02J−01 TCGA−AA−A02H−01 TCGA−AA−A02F−01 TCGA−AA−A01Z−01 TCGA−AA−A01S−01 TCGA−AA−A01K−01 TCGA−AA−A01G−01 TCGA−AA−A01F−01 TCGA−AA−A01D−01 TCGA−AA−A00W−01 TCGA−AA−A00L−01 TCGA−AA−A00F−01 TCGA−AA−A00D−01 TCGA−AA−3982−01 TCGA−AA−3980−01 TCGA−AA−3979−01 TCGA−AA−3976−01 TCGA−AA−3975−01 TCGA−AA−3972−01 TCGA−AA−3956−01 TCGA−AA−3930−01 TCGA−AA−3875−01 TCGA−AA−3869−01 TCGA−AA−3867−01 TCGA−AA−3866−01 TCGA−AA−3858−01 TCGA−AA−3856−01 TCGA−AA−3851−01 TCGA−AA−3848−01 TCGA−AA−3844−01 TCGA−AA−3842−01 TCGA−AA−3814−01 TCGA−AA−3681−01 TCGA−AA−3666−01 TCGA−AA−3562−01 TCGA−AA−3561−01 TCGA−AA−3560−01 TCGA−AA−3558−01 TCGA−AA−3556−01 TCGA−AA−3553−01 TCGA−AA−3549−01 TCGA−AA−3542−01 TCGA−AA−3531−01 TCGA−AA−3526−01 TCGA−AA−3524−01 TCGA−AA−3520−01 TCGA−AA−3519−01 TCGA−AA−3517−01 TCGA−A6−6782−01 TCGA−A6−6654−01 TCGA−A6−6652−01 TCGA−A6−6651−01 TCGA−A6−6649−01 TCGA−A6−6137−01 TCGA−A6−5662−01 TCGA−A6−5656−01 TCGA−A6−3810−01 TCGA−A6−2683−01 TCGA−A6−2678−01 TCGA−A6−2674−01 TCGA−A6−2670−01

TCGA−G4−6628−01 TCGA−CM−6674−01 TCGA−CK−5916−01 TCGA−AA−3950−01 TCGA−DM−A28H−01 TCGA−CK−6746−01 TCGA−AA−3977−01 TCGA−AA−3672−01 TCGA−AA−3496−01 TCGA−CA−6718−01 TCGA−CM−5868−01 TCGA−AZ−4315−01 TCGA−AA−A010−01 TCGA−AA−3492−01 TCGA−G5−6235−01 TCGA−G4−6625−01 TCGA−G4−6309−01 TCGA−F5−6571−01 TCGA−EI−6507−01 TCGA−DY−A1DC−01 TCGA−DT−5265−01 TCGA−DM−A28G−01 TCGA−DM−A282−01 TCGA−DM−A1D6−01 TCGA−D5−7000−01 TCGA−D5−6930−01 TCGA−D5−6924−01 TCGA−D5−6540−01 TCGA−CM−6679−01 TCGA−CM−6171−01 TCGA−CM−4744−01 TCGA−CK−5913−01 TCGA−CK−4952−01 TCGA−CA−6716−01 TCGA−AG−A02N−01 TCGA−AG−3882−01 TCGA−AG−3600−01 TCGA−AG−3578−01 TCGA−AD−6889−01 TCGA−AA−A022−01 TCGA−AA−A01Q−01 TCGA−AA−A01P−01 TCGA−AA−A00J−01 TCGA−AA−3984−01 TCGA−AA−3947−01 TCGA−AA−3939−01 TCGA−AA−3815−01 TCGA−AA−3713−01 TCGA−AA−3695−01 TCGA−AA−3680−01 TCGA−AA−3555−01 TCGA−AA−3510−01 TCGA−A6−6653−01 TCGA−A6−6648−01 TCGA−A6−6137−01 TCGA−A6−5662−01 TCGA−A6−5659−01 TCGA−CA−6717−01 TCGA−AZ−6601−01 TCGA−AZ−6598−01 TCGA−AG−A002−01 TCGA−G4−6588−01 TCGA−DY−A1DG−01 TCGA−DM−A1DB−01 TCGA−D5−6898−01 TCGA−D5−6538−01 TCGA−D5−6536−01 TCGA−CM−6162−01 TCGA−AZ−6599−01 TCGA−AD−6964−01 TCGA−AD−5900−01 TCGA−AA−A02K−01 TCGA−AA−A00N−01 TCGA−AA−A00E−01 TCGA−AA−3966−01 TCGA−AA−3811−01 TCGA−AA−3712−01 TCGA−A6−3809−01 TCGA−G4−6317−01 TCGA−G4−6315−01 TCGA−G4−6307−01 TCGA−G4−6306−01 TCGA−G4−6303−01 TCGA−G4−6299−01 TCGA−F5−6465−01 TCGA−F4−6809−01 TCGA−F4−6808−01 TCGA−F4−6460−01 TCGA−EF−5830−01 TCGA−DY−A1DF−01 TCGA−DY−A1DD−01 TCGA−DY−A0XA−01 TCGA−DM−A28F−01 TCGA−DM−A285−01 TCGA−DM−A1D8−01 TCGA−D5−6928−01 TCGA−D5−6920−01 TCGA−D5−6539−01 TCGA−D5−6537−01 TCGA−D5−6534−01 TCGA−D5−6533−01 TCGA−D5−5540−01 TCGA−D5−5539−01 TCGA−CM−6680−01 TCGA−CM−6677−01 TCGA−CM−6676−01 TCGA−CM−6170−01 TCGA−CM−6169−01 TCGA−CM−6168−01 TCGA−CM−6166−01 TCGA−CM−5862−01 TCGA−CM−5860−01 TCGA−CM−5344−01 TCGA−CK−6751−01 TCGA−CK−6748−01 TCGA−CK−5915−01 TCGA−CK−5914−01 TCGA−AZ−6603−01 TCGA−AZ−6600−01 TCGA−AZ−5407−01 TCGA−AZ−5403−01 TCGA−AY−6196−01 TCGA−AY−5543−01 TCGA−AU−6004−01 TCGA−AU−3779−01 TCGA−AG−3742−01 TCGA−AF−2687−01 TCGA−AD−6901−01 TCGA−AA−A01R−01 TCGA−AA−A00R−01 TCGA−AA−3982−01 TCGA−AA−3968−01 TCGA−AA−3697−01 TCGA−AA−3663−01 TCGA−AA−3542−01 TCGA−AA−3518−01 TCGA−AA−3502−01 TCGA−A6−5660−01

TP53

unknown CG mut

TCGA−A6−6651−01 TCGA−AA−3712−01 TCGA−CM−5348−01 TCGA−A6−6653−01 TCGA−AA−A02O−01 TCGA−AA−3975−01 TCGA−CM−5341−01 TCGA−AA−3525−01 TCGA−CI−6621−01 TCGA−CA−6716−01 TCGA−AA−3950−01 TCGA−F5−6465−01 TCGA−DY−A1DF−01 TCGA−AG−3999−01 TCGA−AA−3688−01 TCGA−CK−4952−01 TCGA−CA−6718−01 TCGA−DC−6157−01 TCGA−AA−A01Q−01 TCGA−AA−3554−01 TCGA−A6−6781−01 TCGA−F4−6856−01 TCGA−DM−A1D4−01 TCGA−D5−6931−01 TCGA−D5−6930−01 TCGA−AA−3672−01 TCGA−AA−3518−01 TCGA−A6−6141−01 TCGA−CK−6746−01 TCGA−DY−A1DC−01 TCGA−CM−6161−01 TCGA−AG−3898−01 TCGA−AG−3892−01 TCGA−AG−3609−01 TCGA−AF−5654−01 TCGA−AA−3848−01 TCGA−AA−A010−01 TCGA−D5−6540−01 TCGA−AG−A002−01 TCGA−AA−A00N−01 TCGA−AA−3984−01 TCGA−G4−6628−01 TCGA−AZ−6603−01 TCGA−AZ−4315−01 TCGA−AA−3510−01 TCGA−CA−6717−01 TCGA−AZ−6601−01 TCGA−AF−6136−01 TCGA−AA−3977−01 TCGA−AA−3966−01 TCGA−AA−3845−01 TCGA−AA−3715−01 TCGA−AZ−6598−01 TCGA−G4−6588−01 TCGA−EI−6507−01 TCGA−D5−6927−01 TCGA−CK−5916−01 TCGA−CK−5913−01 TCGA−AA−3949−01 TCGA−AA−3947−01 TCGA−A6−4105−01 TCGA−F5−6464−01 TCGA−AY−6197−01 TCGA−AD−6964−01 TCGA−AD−5900−01 TCGA−AA−A00J−01 TCGA−AA−3710−01 TCGA−AA−3663−01 TCGA−AA−3516−01 TCGA−A6−6780−01 TCGA−A6−5665−01

TCGA−A6−6648−01 TCGA−CM−5861−01 TCGA−AA−3516−01 TCGA−AA−A01V−01 TCGA−DM−A0X9−01 TCGA−F4−6855−01 TCGA−AA−A024−01 TCGA−AA−3710−01 TCGA−D5−6928−01 TCGA−AD−6964−01 TCGA−AA−3950−01 TCGA−A6−3809−01 TCGA−AG−3892−01 TCGA−AA−A022−01 TCGA−AA−A00K−01 TCGA−AA−3819−01 TCGA−AZ−4315−01 TCGA−A6−6781−01 TCGA−AA−A00J−01 TCGA−AA−A00A−01 TCGA−AA−3966−01 TCGA−AA−3947−01 TCGA−AA−3543−01 TCGA−CK−5913−01 TCGA−AA−A01R−01 TCGA−AA−A00N−01 TCGA−CK−6746−01 TCGA−AA−3672−01 TCGA−A6−2672−01 TCGA−F5−6465−01 TCGA−F4−6809−01 TCGA−AY−6386−01 TCGA−AG−A015−01 TCGA−AG−3599−01 TCGA−AA−A01Q−01 TCGA−AA−3984−01 TCGA−AA−3864−01 TCGA−AA−3850−01 TCGA−AA−3555−01 TCGA−G4−6588−01 TCGA−AG−A002−01 TCGA−AD−6895−01 TCGA−AA−3510−01 TCGA−D5−7000−01 TCGA−CM−6674−01 TCGA−AA−3968−01 TCGA−AA−3715−01 TCGA−AA−3496−01 TCGA−A6−6141−01 TCGA−A6−5661−01 TCGA−F4−6570−01 TCGA−DY−A1H8−01 TCGA−DM−A28G−01 TCGA−DM−A28C−01 TCGA−D5−6534−01 TCGA−D5−5539−01 TCGA−CM−6678−01 TCGA−CM−5344−01 TCGA−CM−4747−01 TCGA−AZ−6603−01 TCGA−AH−6549−01 TCGA−AG−3881−01 TCGA−AD−6889−01 TCGA−AA−3502−01 TCGA−A6−6780−01 TCGA−A6−5666−01 TCGA−AA−A010−01 TCGA−AZ−6598−01 TCGA−CA−6718−01 TCGA−CA−6717−01 TCGA−A6−5665−01 TCGA−G4−6293−01 TCGA−D5−6930−01 TCGA−D5−6927−01 TCGA−D5−6898−01 TCGA−D5−6540−01 TCGA−D5−6532−01 TCGA−CM−6171−01 TCGA−CM−6169−01 TCGA−CM−6162−01 TCGA−CM−5349−01 TCGA−CM−5348−01 TCGA−CM−5341−01 TCGA−CM−4752−01 TCGA−CM−4743−01 TCGA−CK−4952−01 TCGA−AZ−6601−01 TCGA−AY−6197−01 TCGA−AU−6004−01 TCGA−AU−3779−01 TCGA−AF−4110−01 TCGA−AA−3977−01 TCGA−AA−3713−01 TCGA−AA−3492−01 TCGA−G4−6628−01 TCGA−G4−6625−01 TCGA−G4−6586−01 TCGA−G4−6323−01 TCGA−G4−6321−01 TCGA−G4−6317−01 TCGA−G4−6315−01 TCGA−G4−6306−01 TCGA−G4−6304−01 TCGA−G4−6299−01 TCGA−F5−6812−01 TCGA−F5−6464−01 TCGA−F4−6856−01 TCGA−F4−6806−01 TCGA−F4−6460−01 TCGA−EI−6510−01 TCGA−DY−A0XA−01 TCGA−DM−A28H−01 TCGA−DM−A28F−01 TCGA−DM−A1HA−01 TCGA−DM−A1DB−01 TCGA−DM−A1D8−01 TCGA−DM−A1D4−01 TCGA−DM−A0XD−01 TCGA−DC−6682−01 TCGA−D5−6932−01 TCGA−D5−6926−01 TCGA−D5−6923−01 TCGA−D5−6541−01 TCGA−D5−6539−01 TCGA−D5−6535−01 TCGA−D5−6533−01 TCGA−D5−5538−01 TCGA−CM−6676−01 TCGA−CM−6172−01 TCGA−CM−6165−01 TCGA−CM−6161−01 TCGA−CM−5860−01 TCGA−CM−4746−01 TCGA−CM−4744−01 TCGA−CL−5917−01 TCGA−CK−5916−01 TCGA−CK−5914−01 TCGA−CK−4950−01 TCGA−CI−6620−01 TCGA−CI−6619−01 TCGA−CA−6719−01 TCGA−CA−5797−01 TCGA−AZ−6608−01 TCGA−AZ−6600−01 TCGA−AZ−6599−01 TCGA−AZ−5407−01 TCGA−AZ−4323−01 TCGA−AG−A02N−01 TCGA−AG−4005−01 TCGA−AG−3742−01 TCGA−AF−6672−01 TCGA−AF−2693−01 TCGA−AD−6901−01 TCGA−AD−6888−01 TCGA−AD−5900−01 TCGA−AA−A02H−01 TCGA−AA−A00L−01 TCGA−AA−A00E−01 TCGA−AA−3949−01 TCGA−AA−3811−01 TCGA−AA−3697−01 TCGA−AA−3663−01 TCGA−AA−3662−01 TCGA−AA−3655−01 TCGA−AA−3561−01 TCGA−AA−3511−01 TCGA−A6−6652−01 TCGA−A6−6649−01 TCGA−A6−6142−01 TCGA−A6−5662−01 TCGA−A6−4105−01 TCGA−G5−6235−01 TCGA−G4−6626−01 TCGA−G4−6310−01 TCGA−G4−6307−01 TCGA−G4−6303−01 TCGA−F5−6813−01 TCGA−F5−6702−01 TCGA−F5−6571−01 TCGA−F4−6854−01 TCGA−F4−6808−01 TCGA−F4−6807−01 TCGA−F4−6805−01 TCGA−F4−6704−01 TCGA−F4−6703−01 TCGA−F4−6459−01 TCGA−EI−6508−01 TCGA−EI−6507−01 TCGA−EI−6506−01 TCGA−EF−5830−01 TCGA−DY−A1DG−01 TCGA−DY−A1DF−01 TCGA−DY−A1DD−01 TCGA−DY−A1DC−01 TCGA−DT−5265−01 TCGA−DM−A28K−01 TCGA−DM−A28E−01 TCGA−DM−A285−01 TCGA−DM−A1DA−01 TCGA−DM−A1D9−01 TCGA−DM−A1D7−01 TCGA−DM−A1D6−01 TCGA−DM−A1D0−01 TCGA−DM−A0XF−01 TCGA−DC−6683−01 TCGA−DC−6158−01 TCGA−DC−6157−01 TCGA−DC−6155−01 TCGA−DC−5869−01 TCGA−DC−5337−01 TCGA−D5−6931−01 TCGA−D5−6929−01 TCGA−D5−6924−01 TCGA−D5−6922−01 TCGA−D5−6920−01 TCGA−D5−6538−01 TCGA−D5−5541−01 TCGA−D5−5540−01 TCGA−CM−6679−01 TCGA−CM−6677−01 TCGA−CM−6675−01 TCGA−CM−6168−01 TCGA−CM−6166−01 TCGA−CM−6164−01 TCGA−CM−6163−01 TCGA−CM−5868−01 TCGA−CM−5864−01 TCGA−CM−5862−01 TCGA−CL−5918−01 TCGA−CK−4948−01 TCGA−CK−4947−01 TCGA−CI−6624−01 TCGA−CI−6622−01 TCGA−CI−6621−01 TCGA−CA−6716−01 TCGA−AZ−6607−01 TCGA−AZ−6605−01 TCGA−AZ−5403−01 TCGA−AZ−4616−01 TCGA−AY−6196−01 TCGA−AY−5543−01 TCGA−AY−4071−01 TCGA−AY−4070−01 TCGA−AH−6643−01 TCGA−AH−6544−01 TCGA−AG−A036−01 TCGA−AG−A032−01 TCGA−AG−A02X−01 TCGA−AG−A026−01 TCGA−AG−A020−01 TCGA−AG−A01Y−01 TCGA−AG−A01W−01 TCGA−AG−A01L−01 TCGA−AG−A016−01 TCGA−AG−A014−01 TCGA−AG−A011−01 TCGA−AG−A00Y−01 TCGA−AG−A00C−01 TCGA−AG−4015−01 TCGA−AG−4008−01 TCGA−AG−4007−01 TCGA−AG−3999−01 TCGA−AG−3909−01 TCGA−AG−3902−01 TCGA−AG−3898−01 TCGA−AG−3896−01 TCGA−AG−3893−01 TCGA−AG−3890−01 TCGA−AG−3885−01 TCGA−AG−3882−01 TCGA−AG−3732−01 TCGA−AG−3731−01 TCGA−AG−3726−01 TCGA−AG−3612−01 TCGA−AG−3611−01 TCGA−AG−3609−01 TCGA−AG−3608−01 TCGA−AG−3605−01 TCGA−AG−3602−01 TCGA−AG−3601−01 TCGA−AG−3598−01 TCGA−AG−3594−01 TCGA−AG−3587−01 TCGA−AG−3581−01 TCGA−AG−3578−01 TCGA−AG−3575−01 TCGA−AF−6655−01 TCGA−AF−6136−01 TCGA−AF−3913−01 TCGA−AF−3400−01 TCGA−AF−2691−01 TCGA−AF−2689−01 TCGA−AF−2687−01 TCGA−AD−6965−01 TCGA−AD−6963−01 TCGA−AD−6899−01 TCGA−AD−6548−01 TCGA−AA−A03J−01 TCGA−AA−A02W−01 TCGA−AA−A02J−01 TCGA−AA−A02F−01 TCGA−AA−A01Z−01 TCGA−AA−A01T−01 TCGA−AA−A01S−01 TCGA−AA−A01K−01 TCGA−AA−A01G−01 TCGA−AA−A01F−01 TCGA−AA−A01D−01 TCGA−AA−A00W−01 TCGA−AA−A00F−01 TCGA−AA−A00D−01 TCGA−AA−3982−01 TCGA−AA−3980−01 TCGA−AA−3979−01 TCGA−AA−3976−01 TCGA−AA−3975−01 TCGA−AA−3972−01 TCGA−AA−3956−01 TCGA−AA−3930−01 TCGA−AA−3875−01 TCGA−AA−3869−01 TCGA−AA−3867−01 TCGA−AA−3866−01 TCGA−AA−3860−01 TCGA−AA−3858−01 TCGA−AA−3856−01 TCGA−AA−3851−01 TCGA−AA−3848−01 TCGA−AA−3844−01 TCGA−AA−3842−01 TCGA−AA−3815−01 TCGA−AA−3814−01 TCGA−AA−3712−01 TCGA−AA−3693−01 TCGA−AA−3685−01 TCGA−AA−3681−01 TCGA−AA−3679−01 TCGA−AA−3667−01 TCGA−AA−3666−01 TCGA−AA−3660−01 TCGA−AA−3562−01 TCGA−AA−3560−01 TCGA−AA−3558−01 TCGA−AA−3556−01 TCGA−AA−3553−01 TCGA−AA−3552−01 TCGA−AA−3549−01 TCGA−AA−3542−01 TCGA−AA−3531−01 TCGA−AA−3526−01 TCGA−AA−3524−01 TCGA−AA−3520−01 TCGA−AA−3519−01 TCGA−AA−3517−01 TCGA−A6−6782−01 TCGA−A6−6654−01 TCGA−A6−6651−01 TCGA−A6−6138−01 TCGA−A6−6137−01 TCGA−A6−5659−01 TCGA−A6−5656−01 TCGA−A6−3810−01 TCGA−A6−3807−01 TCGA−A6−2683−01 TCGA−A6−2678−01 TCGA−A6−2676−01 TCGA−A6−2674−01 TCGA−A6−2670−01

Senescence And Autophagy In Cancer FDR = 1.9e−12%, FDR nod = 0.72%

unknown CG mut

Processive Synthesis On The C Strand Of The Telomere Telomere C Strand (Lagging Strand) Synthesis FDR = 1.9e−12%, FDR nod = 2.3e−11%

JUN

POLD2

wt

POLD1

wt UBN1

known HCG mut

RFC1

EP400

Polymerase Switching Polymerase Switching On The C Strand Of The Telomere FDR = 4.4%, FDR nod = 4.6%

Formation Of Senescence Associated Heterochromatin Foci (SAHF) FDR = 1.9e−12%, FDR nod = 2.3e−11%

POLD1

RB1

EGFR

POLA2

HIST1H1A

POLD2

ASF1A

PRIM2

HIST1H1B

RFC4

LMNB1

known HCG mut LIG1

ING1

POLD3

IRF1

PCNA

IFNB1


LRRK2

wt wt

GPNMB

HIF1A

HBEGF

PTK6

wt POLD3

HIRA

unknown CG mut TP53 ATM EP400 RAD50 CCNA1 CCNE1 TERF2IP CCNA2 CDK2 CDKN1A CDKN1B H2AFB1 HIST1H2AJ HIST1H2BE HIST1H2BH ACD CCNE2 H2AFX H2AFZ HIST1H2AB HIST1H2AC HIST1H2AE HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BF HIST1H2BG HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BO HIST1H4A HIST1H4B HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4L HIST2H2AA4 HIST2H2AC HIST2H2BE HIST3H2BB HIST3H3 HIST4H4 KAT5 MRE11A NBN POT1 TERF1 TERF2 TINF2 unknown CG mut

unknown CG mut

CABIN1

POLA1

known HCG mut

HIST1H1C

CDKN1A

PCNA

HIST1H1E

RFC5

HIST1H1D

HMGA1

RFC2

HMGA2

PRIM1

unknown CG mut

TP53

known HCG mut

MTOR

wt

TCGA−D5−6928−01 TCGA−AA−3831−01 TCGA−AA−A03F−01 TCGA−AA−3502−01 TCGA−A6−2672−01 TCGA−F4−6570−01 TCGA−AA−3710−01 TCGA−G4−6309−01 TCGA−DM−A282−01 TCGA−AG−A002−01 TCGA−AG−3892−01 TCGA−AA−A00K−01 TCGA−AA−3984−01 TCGA−AA−3877−01 TCGA−AA−3854−01 TCGA−AA−3821−01 TCGA−AA−3715−01 TCGA−AA−3555−01 TCGA−A6−6781−01 TCGA−A6−6141−01 TCGA−A6−5666−01 TCGA−AA−3663−01 TCGA−G4−6586−01 TCGA−DM−A28K−01 TCGA−DM−A1D4−01 TCGA−AA−A010−01 TCGA−AA−3949−01 TCGA−G4−6307−01 TCGA−F4−6806−01 TCGA−EF−5830−01 TCGA−DY−A1DD−01 TCGA−DT−5265−01 TCGA−DC−5869−01 TCGA−D5−6927−01 TCGA−CM−6172−01 TCGA−CM−6164−01 TCGA−CM−6161−01 TCGA−CM−4752−01 TCGA−CK−4950−01 TCGA−CA−6717−01 TCGA−CA−6716−01 TCGA−AZ−6601−01 TCGA−AZ−6598−01 TCGA−AY−6197−01 TCGA−AY−5543−01 TCGA−AU−6004−01 TCGA−AF−3913−01 TCGA−AA−A01F−01 TCGA−AA−3980−01 TCGA−AA−3956−01 TCGA−AA−3867−01 TCGA−AA−3713−01 TCGA−AA−3666−01 TCGA−A6−6651−01 TCGA−A6−4105−01 TCGA−G5−6235−01 TCGA−G4−6628−01 TCGA−G4−6626−01 TCGA−G4−6625−01 TCGA−G4−6323−01 TCGA−G4−6321−01 TCGA−G4−6317−01 TCGA−G4−6315−01 TCGA−G4−6310−01 TCGA−G4−6306−01 TCGA−G4−6304−01 TCGA−G4−6303−01 TCGA−G4−6299−01 TCGA−G4−6293−01 TCGA−F5−6813−01 TCGA−F5−6812−01 TCGA−F5−6702−01 TCGA−F5−6571−01 TCGA−F5−6464−01 TCGA−F4−6856−01 TCGA−F4−6854−01 TCGA−F4−6808−01 TCGA−F4−6807−01 TCGA−F4−6805−01 TCGA−F4−6704−01 TCGA−F4−6703−01 TCGA−F4−6460−01 TCGA−F4−6459−01 TCGA−EI−6510−01 TCGA−EI−6508−01 TCGA−EI−6507−01 TCGA−EI−6506−01 TCGA−DY−A1DG−01 TCGA−DY−A1DF−01 TCGA−DY−A1DC−01 TCGA−DY−A0XA−01 TCGA−DM−A28H−01 TCGA−DM−A28F−01 TCGA−DM−A28E−01 TCGA−DM−A285−01 TCGA−DM−A1HA−01 TCGA−DM−A1DB−01 TCGA−DM−A1DA−01 TCGA−DM−A1D9−01 TCGA−DM−A1D8−01 TCGA−DM−A1D7−01 TCGA−DM−A1D6−01 TCGA−DM−A1D0−01 TCGA−DM−A0XF−01 TCGA−DM−A0XD−01 TCGA−DC−6683−01 TCGA−DC−6682−01 TCGA−DC−6158−01 TCGA−DC−6157−01 TCGA−DC−6155−01 TCGA−DC−5337−01 TCGA−D5−6932−01 TCGA−D5−6931−01 TCGA−D5−6930−01 TCGA−D5−6929−01 TCGA−D5−6926−01 TCGA−D5−6924−01 TCGA−D5−6923−01 TCGA−D5−6922−01 TCGA−D5−6920−01 TCGA−D5−6898−01 TCGA−D5−6541−01 TCGA−D5−6540−01 TCGA−D5−6539−01 TCGA−D5−6538−01 TCGA−D5−6535−01 TCGA−D5−6533−01 TCGA−D5−6532−01 TCGA−D5−5541−01 TCGA−D5−5540−01 TCGA−D5−5538−01 TCGA−CM−6679−01 TCGA−CM−6677−01 TCGA−CM−6676−01 TCGA−CM−6675−01 TCGA−CM−6171−01 TCGA−CM−6169−01 TCGA−CM−6168−01 TCGA−CM−6166−01 TCGA−CM−6165−01 TCGA−CM−6163−01 TCGA−CM−6162−01 TCGA−CM−5868−01 TCGA−CM−5864−01 TCGA−CM−5862−01 TCGA−CM−5860−01 TCGA−CM−5349−01 TCGA−CM−5348−01 TCGA−CM−5341−01 TCGA−CM−4746−01 TCGA−CM−4744−01 TCGA−CM−4743−01 TCGA−CL−5918−01 TCGA−CL−5917−01 TCGA−CK−5916−01 TCGA−CK−5914−01 TCGA−CK−4952−01 TCGA−CK−4948−01 TCGA−CK−4947−01 TCGA−CI−6624−01 TCGA−CI−6622−01 TCGA−CI−6621−01 TCGA−CI−6620−01 TCGA−CI−6619−01 TCGA−CA−6719−01 TCGA−CA−6718−01 TCGA−CA−5797−01 TCGA−AZ−6608−01 TCGA−AZ−6607−01 TCGA−AZ−6605−01 TCGA−AZ−6600−01 TCGA−AZ−6599−01 TCGA−AZ−5407−01 TCGA−AZ−5403−01 TCGA−AZ−4616−01 TCGA−AZ−4323−01 TCGA−AY−6196−01 TCGA−AY−4071−01 TCGA−AY−4070−01 TCGA−AU−3779−01 TCGA−AH−6643−01 TCGA−AH−6544−01 TCGA−AG−A036−01 TCGA−AG−A032−01 TCGA−AG−A02X−01 TCGA−AG−A02N−01 TCGA−AG−A026−01 TCGA−AG−A020−01 TCGA−AG−A01Y−01 TCGA−AG−A01W−01 TCGA−AG−A01L−01 TCGA−AG−A016−01 TCGA−AG−A014−01 TCGA−AG−A011−01 TCGA−AG−A00Y−01 TCGA−AG−A00C−01 TCGA−AG−4015−01 TCGA−AG−4008−01 TCGA−AG−4007−01 TCGA−AG−4005−01 TCGA−AG−3999−01 TCGA−AG−3909−01 TCGA−AG−3902−01 TCGA−AG−3898−01 TCGA−AG−3896−01 TCGA−AG−3893−01 TCGA−AG−3890−01 TCGA−AG−3885−01 TCGA−AG−3882−01 TCGA−AG−3742−01 TCGA−AG−3732−01 TCGA−AG−3731−01 TCGA−AG−3726−01 TCGA−AG−3612−01 TCGA−AG−3611−01 TCGA−AG−3609−01 TCGA−AG−3608−01 TCGA−AG−3605−01 TCGA−AG−3602−01 TCGA−AG−3601−01 TCGA−AG−3598−01 TCGA−AG−3594−01 TCGA−AG−3587−01 TCGA−AG−3581−01 TCGA−AG−3578−01 TCGA−AG−3575−01 TCGA−AF−6672−01 TCGA−AF−6655−01 TCGA−AF−6136−01 TCGA−AF−4110−01 TCGA−AF−3400−01 TCGA−AF−2693−01 TCGA−AF−2691−01 TCGA−AF−2689−01 TCGA−AF−2687−01 TCGA−AD−6965−01 TCGA−AD−6963−01 TCGA−AD−6901−01 TCGA−AD−6899−01 TCGA−AD−6888−01 TCGA−AD−6548−01 TCGA−AD−5900−01 TCGA−AA−A03J−01 TCGA−AA−A02W−01 TCGA−AA−A02J−01 TCGA−AA−A02H−01 TCGA−AA−A02F−01 TCGA−AA−A01Z−01 TCGA−AA−A01T−01 TCGA−AA−A01S−01 TCGA−AA−A01K−01 TCGA−AA−A01G−01 TCGA−AA−A01D−01 TCGA−AA−A00W−01 TCGA−AA−A00L−01 TCGA−AA−A00F−01 TCGA−AA−A00E−01 TCGA−AA−A00D−01 TCGA−AA−3982−01 TCGA−AA−3979−01 TCGA−AA−3977−01 TCGA−AA−3976−01 TCGA−AA−3975−01 TCGA−AA−3972−01 TCGA−AA−3930−01 TCGA−AA−3875−01 TCGA−AA−3869−01 TCGA−AA−3866−01 TCGA−AA−3860−01 TCGA−AA−3858−01 TCGA−AA−3856−01 TCGA−AA−3851−01 TCGA−AA−3848−01 TCGA−AA−3844−01 TCGA−AA−3842−01 TCGA−AA−3815−01 TCGA−AA−3814−01 TCGA−AA−3811−01 TCGA−AA−3712−01 TCGA−AA−3697−01 TCGA−AA−3693−01 TCGA−AA−3685−01 TCGA−AA−3681−01 TCGA−AA−3679−01 TCGA−AA−3667−01 TCGA−AA−3662−01 TCGA−AA−3660−01 TCGA−AA−3655−01 TCGA−AA−3562−01 TCGA−AA−3561−01 TCGA−AA−3560−01 TCGA−AA−3558−01 TCGA−AA−3556−01 TCGA−AA−3553−01 TCGA−AA−3552−01 TCGA−AA−3549−01 TCGA−AA−3542−01 TCGA−AA−3531−01 TCGA−AA−3526−01 TCGA−AA−3524−01 TCGA−AA−3520−01 TCGA−AA−3519−01 TCGA−AA−3517−01 TCGA−AA−3511−01 TCGA−AA−3492−01 TCGA−A6−6782−01 TCGA−A6−6654−01 TCGA−A6−6652−01 TCGA−A6−6649−01 TCGA−A6−6142−01 TCGA−A6−6138−01 TCGA−A6−6137−01 TCGA−A6−5665−01 TCGA−A6−5662−01 TCGA−A6−5659−01 TCGA−A6−5656−01 TCGA−A6−3810−01 TCGA−A6−3807−01 TCGA−A6−2683−01 TCGA−A6−2678−01 TCGA−A6−2676−01 TCGA−A6−2674−01 TCGA−A6−2670−01

TCGA−CM−5341−01 TCGA−AA−3525−01 TCGA−F5−6465−01 TCGA−DY−A1DF−01 TCGA−AG−3999−01 TCGA−AA−A010−01 TCGA−AA−3688−01 TCGA−G4−6628−01 TCGA−DM−A1D4−01 TCGA−AZ−4315−01 TCGA−AA−3672−01 TCGA−AA−3518−01 TCGA−A6−6781−01 TCGA−D5−6927−01 TCGA−F5−6464−01 TCGA−AD−6964−01 TCGA−AD−5900−01 TCGA−AA−A00J−01 TCGA−AA−3949−01 TCGA−AA−3947−01 TCGA−AA−3710−01 TCGA−AA−3663−01 TCGA−AA−3516−01 TCGA−A6−6780−01 TCGA−A6−4105−01 TCGA−G4−6588−01 TCGA−EI−6507−01 TCGA−F4−6856−01 TCGA−D5−6931−01 TCGA−D5−6930−01 TCGA−D5−6540−01 TCGA−CK−5916−01 TCGA−CK−5913−01 TCGA−AZ−6598−01 TCGA−AY−6197−01 TCGA−A6−6141−01 TCGA−A6−5665−01 TCGA−G4−6306−01 TCGA−G4−6304−01 TCGA−G4−6303−01 TCGA−G4−6299−01 TCGA−F5−6812−01 TCGA−F4−6570−01 TCGA−F4−6460−01 TCGA−EI−6510−01 TCGA−DM−A28F−01 TCGA−DM−A1DB−01 TCGA−DM−A1D6−01 TCGA−DC−6683−01 TCGA−DC−6155−01 TCGA−DC−5337−01 TCGA−D5−6928−01 TCGA−D5−6920−01 TCGA−D5−6898−01 TCGA−D5−6541−01 TCGA−D5−6536−01 TCGA−D5−5540−01 TCGA−CM−6171−01 TCGA−CM−6164−01 TCGA−CL−5917−01 TCGA−CK−5915−01 TCGA−CK−4952−01 TCGA−CI−6624−01 TCGA−CA−6719−01 TCGA−AZ−6608−01 TCGA−AZ−6601−01 TCGA−AZ−6600−01 TCGA−AZ−4682−01 TCGA−AU−6004−01 TCGA−AG−3732−01 TCGA−AD−6889−01 TCGA−AA−A022−01 TCGA−AA−A00N−01 TCGA−AA−3864−01 TCGA−AA−3510−01 TCGA−AA−3492−01 TCGA−AA−3489−01 TCGA−A6−6138−01 TCGA−A6−6137−01 TCGA−A6−5662−01 TCGA−A6−5660−01

Cyclin D Associated Events In G1 FDR = 0.79%, FDR nod = 1.9% Cyclin A:Cdk2 Associated Events At S Phase Entry FDR = 1.9e−12%, FDR nod = 2.3e−11%

RBL2

RB1

CCNH CCNH

CDK4 CDC25A

CDKN2A

PPP2R3B

CDKN1B

CDK6 WEE1

E2F3 MYC

PPP2CA CCNA2

SKP2

TFDP2

CDK2

CCND1

CCND2

CDK7

CDKN2C MAX

E2F4 CDKN1A

PPP2R1B FZR1

UBA52 UBC

MNAT1

TCGA−AA−3710−01 TCGA−AF−2687−01 TCGA−AA−3855−01 TCGA−AA−3877−01 TCGA−A6−6781−01 TCGA−DC−6683−01 TCGA−AG−A036−01 TCGA−AA−3712−01 TCGA−AA−3984−01 TCGA−D5−6930−01 TCGA−G4−6309−01 TCGA−AD−6964−01 TCGA−AF−6136−01 TCGA−AA−3660−01 TCGA−AG−3892−01 TCGA−AG−A025−01 TCGA−AA−3950−01 TCGA−DM−A1D0−01 TCGA−A6−5656−01 TCGA−CK−6746−01 TCGA−CK−5913−01 TCGA−A6−6782−01 TCGA−AY−6196−01 TCGA−AG−A02N−01 TCGA−A6−3808−01 TCGA−AA−3693−01 TCGA−F4−6856−01 TCGA−CA−6716−01 TCGA−AA−3947−01 TCGA−D5−6536−01 TCGA−AA−A00R−01 TCGA−G4−6628−01 TCGA−F4−6569−01 TCGA−CM−6168−01 TCGA−A6−2676−01 TCGA−F4−6855−01 TCGA−D5−6931−01 TCGA−CM−6679−01 TCGA−AZ−6608−01 TCGA−AY−6386−01 TCGA−AA−A00N−01 TCGA−A6−6654−01 TCGA−AA−3663−01 TCGA−A6−6653−01 TCGA−AA−A01R−01 TCGA−G4−6626−01 TCGA−D5−6928−01 TCGA−AZ−5407−01 TCGA−AA−A02O−01 TCGA−AA−3846−01 TCGA−AA−3514−01 TCGA−AA−3516−01 TCGA−CK−5916−01 TCGA−AA−3525−01 TCGA−A6−2672−01 TCGA−F4−6807−01 TCGA−DM−A1HA−01 TCGA−AG−3611−01 TCGA−AA−3949−01 TCGA−AA−3815−01 TCGA−AA−3543−01 TCGA−AZ−4315−01 TCGA−AA−3977−01 TCGA−AD−5900−01 TCGA−A6−3809−01 TCGA−CM−5861−01 TCGA−CA−6718−01 TCGA−AA−A022−01 TCGA−AA−A01Q−01 TCGA−AA−3864−01 TCGA−CM−5864−01 TCGA−AZ−6605−01 TCGA−AA−3558−01 TCGA−AA−3554−01 TCGA−CA−6717−01 TCGA−G4−6588−01 TCGA−AA−A010−01 TCGA−CM−6162−01 TCGA−D5−6540−01 TCGA−CK−4952−01 TCGA−AA−3510−01 TCGA−F4−6570−01 TCGA−CM−4743−01 TCGA−AZ−6601−01 TCGA−AU−6004−01 TCGA−AG−A002−01 TCGA−AD−6895−01 TCGA−AA−3715−01 TCGA−AA−3713−01 TCGA−A6−5665−01 TCGA−G4−6586−01 TCGA−G4−6315−01 TCGA−G4−6293−01 TCGA−F5−6812−01 TCGA−DY−A0XA−01 TCGA−DM−A28F−01 TCGA−D5−6923−01 TCGA−D5−6534−01 TCGA−D5−6532−01 TCGA−D5−5538−01 TCGA−CM−6678−01 TCGA−CM−6169−01 TCGA−CM−5349−01 TCGA−CM−5344−01 TCGA−CM−4752−01 TCGA−AY−6197−01 TCGA−AG−3742−01 TCGA−AF−4110−01 TCGA−AD−6901−01 TCGA−AD−6889−01 TCGA−AA−3968−01 TCGA−AA−3811−01 TCGA−A6−6780−01 TCGA−A6−6652−01 TCGA−A6−6141−01 TCGA−A6−5661−01 TCGA−G4−6625−01 TCGA−G4−6323−01 TCGA−G4−6321−01 TCGA−G4−6317−01 TCGA−G4−6306−01 TCGA−G4−6304−01 TCGA−G4−6299−01 TCGA−F5−6464−01 TCGA−F4−6806−01 TCGA−EI−6510−01 TCGA−DY−A1H8−01 TCGA−DM−A28H−01 TCGA−DM−A28G−01 TCGA−DM−A28C−01 TCGA−DM−A1D4−01 TCGA−DM−A0XD−01 TCGA−D5−7000−01 TCGA−D5−6932−01 TCGA−D5−6927−01 TCGA−D5−6898−01 TCGA−D5−6539−01 TCGA−D5−6535−01 TCGA−D5−6533−01 TCGA−D5−5539−01 TCGA−CM−6676−01 TCGA−CM−6674−01 TCGA−CM−6172−01 TCGA−CM−6171−01 TCGA−CM−6165−01 TCGA−CM−6161−01 TCGA−CM−5860−01 TCGA−CM−5348−01 TCGA−CM−5341−01 TCGA−CM−4747−01 TCGA−CK−4950−01 TCGA−CI−6620−01 TCGA−CI−6619−01 TCGA−CA−6719−01 TCGA−CA−5797−01 TCGA−AZ−6603−01 TCGA−AZ−6600−01 TCGA−AZ−6599−01 TCGA−AZ−6598−01 TCGA−AZ−4323−01 TCGA−AU−3779−01 TCGA−AH−6549−01 TCGA−AG−3881−01 TCGA−AF−6672−01 TCGA−AF−2693−01 TCGA−AA−3697−01 TCGA−AA−3662−01 TCGA−AA−3655−01 TCGA−AA−3502−01 TCGA−AA−3496−01 TCGA−A6−6649−01 TCGA−A6−6142−01 TCGA−A6−5666−01 TCGA−A6−5662−01 TCGA−A6−4105−01

TCGA−DC−6683−01 TCGA−AA−A01R−01 TCGA−AA−3712−01 TCGA−AA−3994−01 TCGA−AA−3864−01 TCGA−AA−A01V−01 TCGA−AA−A01T−01 TCGA−DM−A28K−01 TCGA−A6−5660−01 TCGA−A6−5659−01 TCGA−CM−5861−01 TCGA−CA−5254−01 TCGA−AA−A022−01 TCGA−AA−3821−01 TCGA−A6−6653−01 TCGA−D5−6928−01 TCGA−AG−A025−01 TCGA−AG−3892−01 TCGA−AA−3693−01 TCGA−AA−3492−01 TCGA−CA−6718−01 TCGA−AY−6196−01 TCGA−AA−3514−01 TCGA−A6−2672−01 TCGA−G4−6307−01 TCGA−CK−5913−01 TCGA−CK−5912−01 TCGA−AA−A00J−01 TCGA−A6−6648−01 TCGA−AA−A00R−01 TCGA−AA−3977−01 TCGA−G4−6628−01 TCGA−G4−6626−01 TCGA−F4−6569−01 TCGA−D5−6536−01 TCGA−CM−6168−01 TCGA−AZ−4315−01 TCGA−AA−3516−01 TCGA−A6−6781−01 TCGA−CM−6680−01 TCGA−AD−6963−01 TCGA−AA−3947−01 TCGA−AA−3860−01 TCGA−AA−3845−01 TCGA−CA−6717−01 TCGA−CM−6171−01 TCGA−CM−6162−01 TCGA−CK−4952−01 TCGA−AZ−6598−01 TCGA−AD−6895−01 TCGA−AA−3510−01 TCGA−A6−5661−01 TCGA−G4−6588−01 TCGA−G4−6315−01 TCGA−G4−6306−01 TCGA−G4−6304−01 TCGA−G4−6293−01 TCGA−F4−6570−01 TCGA−DY−A1H8−01 TCGA−DM−A28C−01 TCGA−D5−6540−01 TCGA−CM−6674−01 TCGA−CM−5348−01 TCGA−CM−5344−01 TCGA−CM−4743−01 TCGA−AZ−6601−01 TCGA−AZ−6599−01 TCGA−AU−6004−01 TCGA−AG−A002−01 TCGA−AA−A010−01 TCGA−AA−3715−01 TCGA−AA−3713−01 TCGA−AA−3662−01 TCGA−G4−6625−01 TCGA−G4−6586−01 TCGA−G4−6323−01 TCGA−G4−6321−01 TCGA−G4−6317−01 TCGA−G4−6299−01 TCGA−F5−6812−01 TCGA−F5−6464−01 TCGA−F4−6806−01 TCGA−EI−6510−01 TCGA−DY−A0XA−01 TCGA−DM−A28H−01 TCGA−DM−A28G−01 TCGA−DM−A28F−01 TCGA−DM−A1D4−01 TCGA−DM−A0XD−01 TCGA−D5−7000−01 TCGA−D5−6932−01 TCGA−D5−6927−01 TCGA−D5−6923−01 TCGA−D5−6898−01 TCGA−D5−6539−01 TCGA−D5−6535−01 TCGA−D5−6534−01 TCGA−D5−6533−01 TCGA−D5−6532−01 TCGA−D5−5539−01 TCGA−D5−5538−01 TCGA−CM−6678−01 TCGA−CM−6676−01 TCGA−CM−6172−01 TCGA−CM−6169−01 TCGA−CM−6165−01 TCGA−CM−6161−01 TCGA−CM−5860−01 TCGA−CM−5349−01 TCGA−CM−5341−01 TCGA−CM−4752−01 TCGA−CM−4747−01 TCGA−CK−4950−01 TCGA−CI−6620−01 TCGA−CI−6619−01 TCGA−CA−6719−01 TCGA−CA−5797−01 TCGA−AZ−6603−01 TCGA−AZ−6600−01 TCGA−AZ−4323−01 TCGA−AY−6197−01 TCGA−AU−3779−01 TCGA−AH−6549−01 TCGA−AG−3881−01 TCGA−AG−3742−01 TCGA−AF−6672−01 TCGA−AF−4110−01 TCGA−AF−2693−01 TCGA−AD−6901−01 TCGA−AD−6889−01 TCGA−AA−3968−01 TCGA−AA−3811−01 TCGA−AA−3697−01 TCGA−AA−3655−01 TCGA−AA−3502−01 TCGA−AA−3496−01 TCGA−A6−6780−01 TCGA−A6−6652−01 TCGA−A6−6649−01 TCGA−A6−6142−01 TCGA−A6−6141−01 TCGA−A6−5666−01 TCGA−A6−5665−01 TCGA−A6−5662−01 TCGA−A6−4105−01

unknown CG mut

wt

TCGA−CM−6167−01 TCGA−A6−2671−01 TCGA−AA−A01P−01 TCGA−A6−5657−01 TCGA−AG−4001−01 TCGA−F5−6465−01 TCGA−AA−3821−01 TCGA−AA−3994−01 TCGA−D5−5537−01 TCGA−AA−A004−01 TCGA−AA−3877−01 TCGA−AG−A00H−01 TCGA−AG−3887−01 TCGA−AA−A01Q−01 TCGA−DC−6681−01 TCGA−CM−5344−01 TCGA−AA−3845−01 TCGA−AZ−6606−01 TCGA−AG−A025−01 TCGA−AA−3672−01 TCGA−AA−3812−01 TCGA−CM−6674−01 TCGA−CK−5915−01 TCGA−AA−3554−01 TCGA−CM−5863−01 TCGA−DM−A0X9−01 TCGA−F4−6569−01 TCGA−DM−A282−01 TCGA−AA−A00A−01 TCGA−AD−6895−01 TCGA−D5−6534−01 TCGA−CM−6678−01 TCGA−AA−A00J−01 TCGA−A6−2672−01 TCGA−AA−3864−01 TCGA−DC−6160−01 TCGA−CA−5255−01 TCGA−AH−6549−01 TCGA−AA−3543−01 TCGA−A6−6648−01 TCGA−AA−3715−01 TCGA−AA−3947−01 TCGA−A6−3809−01 TCGA−AD−6964−01 TCGA−AA−3696−01 TCGA−AA−A01V−01 TCGA−AF−5654−01 TCGA−AG−A002−01 TCGA−AZ−4315−01 TCGA−AA−A00N−01 TCGA−AA−3984−01 TCGA−AA−3510−01 TCGA−CK−6746−01 TCGA−AG−3892−01 TCGA−G4−6588−01 TCGA−AA−A022−01 TCGA−AA−3496−01 TCGA−A6−6781−01 TCGA−F4−6570−01 TCGA−CM−5861−01 TCGA−G4−6309−01 TCGA−AD−6889−01 TCGA−A6−6653−01 TCGA−A6−5661−01 TCGA−D5−6928−01 TCGA−AA−3950−01 TCGA−D5−6536−01 TCGA−AA−3966−01 TCGA−AA−3518−01 TCGA−AA−3516−01 TCGA−A6−6780−01 TCGA−A6−6141−01 TCGA−F4−6809−01 TCGA−D5−5539−01 TCGA−CM−6170−01 TCGA−CK−6751−01 TCGA−CK−5913−01 TCGA−AA−A01R−01 TCGA−AA−3710−01 TCGA−AA−3664−01 TCGA−G5−6641−01 TCGA−DY−A1H8−01 TCGA−DM−A28C−01 TCGA−D5−6529−01 TCGA−CM−6680−01 TCGA−CK−5912−01 TCGA−AZ−6603−01 TCGA−AA−3819−01 TCGA−AA−3555−01 TCGA−AA−3527−01 TCGA−AA−3502−01 TCGA−A6−5664−01 TCGA−DM−A28G−01 TCGA−D5−7000−01 TCGA−D5−6537−01 TCGA−CK−6748−01 TCGA−CA−6715−01 TCGA−AZ−4682−01 TCGA−AG−3727−01 TCGA−AG−3600−01 TCGA−AD−6890−01 TCGA−AA−A02Y−01 TCGA−AA−3861−01 TCGA−AA−3678−01 TCGA−AA−3530−01 TCGA−AA−3522−01 TCGA−A6−5660−01 TCGA−CA−6717−01 TCGA−AA−A010−01 TCGA−AZ−6598−01 TCGA−A6−5665−01 TCGA−AA−3663−01 TCGA−AA−3713−01 TCGA−CM−6162−01 TCGA−CA−6718−01 TCGA−AA−3492−01 TCGA−G4−6628−01 TCGA−AA−3977−01 TCGA−G4−6586−01 TCGA−CM−4743−01 TCGA−AY−6197−01 TCGA−AA−3815−01 TCGA−F4−6856−01 TCGA−D5−6540−01 TCGA−CM−5348−01 TCGA−CK−5916−01 TCGA−AZ−6599−01 TCGA−G4−6317−01 TCGA−EI−6507−01 TCGA−CM−6171−01 TCGA−CM−4746−01 TCGA−CK−4952−01 TCGA−AU−6004−01 TCGA−AD−5900−01 TCGA−AA−3811−01 TCGA−A6−2676−01 TCGA−G4−6293−01 TCGA−DM−A1D6−01 TCGA−D5−6930−01 TCGA−D5−6927−01 TCGA−CM−5862−01 TCGA−CA−6716−01 TCGA−AZ−6601−01 TCGA−AZ−6600−01 TCGA−G4−6315−01 TCGA−G4−6306−01 TCGA−G4−6304−01 TCGA−F4−6808−01 TCGA−EF−5830−01 TCGA−DY−A1DD−01 TCGA−DM−A0XF−01 TCGA−D5−6929−01 TCGA−D5−6541−01 TCGA−D5−6538−01 TCGA−D5−5538−01 TCGA−CM−6677−01 TCGA−CM−5864−01 TCGA−CM−4752−01 TCGA−CK−4950−01 TCGA−CK−4948−01 TCGA−CI−6619−01 TCGA−AZ−6608−01 TCGA−AH−6544−01 TCGA−AG−3885−01 TCGA−AF−2693−01 TCGA−A6−4105−01 TCGA−A6−3807−01 TCGA−G4−6321−01 TCGA−G4−6307−01 TCGA−G4−6299−01 TCGA−F5−6813−01 TCGA−F4−6806−01 TCGA−EI−6506−01 TCGA−DY−A1DF−01 TCGA−DY−A1DC−01 TCGA−DM−A28E−01 TCGA−DM−A1HA−01 TCGA−DM−A1DB−01 TCGA−DM−A1D4−01 TCGA−DC−5869−01 TCGA−DC−5337−01 TCGA−D5−6931−01 TCGA−D5−6924−01 TCGA−D5−6920−01 TCGA−D5−6539−01 TCGA−D5−6535−01 TCGA−CM−6161−01 TCGA−CM−5860−01 TCGA−CM−5349−01 TCGA−CM−4744−01 TCGA−CL−5917−01 TCGA−CK−5914−01 TCGA−CK−4947−01 TCGA−CA−5797−01 TCGA−AZ−5407−01 TCGA−AY−5543−01 TCGA−AH−6643−01 TCGA−AG−3731−01 TCGA−AD−6963−01 TCGA−AD−6901−01 TCGA−AA−3860−01 TCGA−AA−3712−01 TCGA−AA−3655−01 TCGA−AA−3511−01 TCGA−A6−6782−01 TCGA−A6−6651−01 TCGA−A6−6142−01 TCGA−G5−6235−01 TCGA−G4−6626−01 TCGA−G4−6323−01 TCGA−G4−6303−01 TCGA−F5−6812−01 TCGA−F5−6702−01 TCGA−F4−6854−01 TCGA−F4−6807−01 TCGA−F4−6703−01 TCGA−F4−6460−01 TCGA−EI−6510−01 TCGA−EI−6508−01 TCGA−DY−A0XA−01 TCGA−DT−5265−01 TCGA−DM−A28K−01 TCGA−DM−A28H−01 TCGA−DM−A28F−01 TCGA−DM−A285−01 TCGA−DM−A1DA−01 TCGA−DM−A1D8−01 TCGA−DM−A1D0−01 TCGA−DM−A0XD−01 TCGA−DC−6683−01 TCGA−DC−6682−01 TCGA−DC−6158−01 TCGA−DC−6155−01 TCGA−D5−6932−01 TCGA−D5−6923−01 TCGA−D5−6922−01 TCGA−D5−6898−01 TCGA−D5−6533−01 TCGA−D5−6532−01 TCGA−CM−6679−01 TCGA−CM−6676−01 TCGA−CM−6675−01 TCGA−CM−6172−01 TCGA−CM−6169−01 TCGA−CM−6166−01 TCGA−CM−6165−01 TCGA−CM−6164−01 TCGA−CM−6163−01 TCGA−CM−5868−01 TCGA−CI−6624−01 TCGA−CI−6621−01 TCGA−CI−6620−01 TCGA−CA−6719−01 TCGA−AZ−5403−01 TCGA−AY−6196−01 TCGA−AY−4071−01 TCGA−AY−4070−01 TCGA−AU−3779−01 TCGA−AG−A032−01 TCGA−AG−A016−01 TCGA−AG−3909−01 TCGA−AG−3896−01 TCGA−AG−3742−01 TCGA−AG−3732−01 TCGA−AG−3601−01 TCGA−AF−6672−01 TCGA−AF−6655−01 TCGA−AF−2687−01 TCGA−AD−6899−01 TCGA−AD−6548−01 TCGA−AA−A02J−01 TCGA−AA−A01T−01 TCGA−AA−A00E−01 TCGA−AA−3980−01 TCGA−AA−3972−01 TCGA−AA−3949−01 TCGA−AA−3814−01 TCGA−AA−3697−01 TCGA−AA−3685−01 TCGA−AA−3679−01 TCGA−AA−3667−01 TCGA−AA−3662−01 TCGA−AA−3660−01 TCGA−AA−3552−01 TCGA−A6−6654−01 TCGA−A6−6652−01 TCGA−A6−6649−01 TCGA−A6−6138−01 TCGA−A6−5656−01 TCGA−A6−2678−01 TCGA−G4−6625−01 TCGA−G4−6310−01 TCGA−F5−6571−01 TCGA−F5−6464−01 TCGA−F4−6805−01 TCGA−F4−6704−01 TCGA−F4−6459−01 TCGA−DY−A1DG−01 TCGA−DM−A1D9−01 TCGA−DM−A1D7−01 TCGA−DC−6157−01 TCGA−D5−6926−01 TCGA−D5−5541−01 TCGA−D5−5540−01 TCGA−CM−6168−01 TCGA−CM−5341−01 TCGA−CL−5918−01 TCGA−CI−6622−01 TCGA−AZ−6607−01 TCGA−AZ−6605−01 TCGA−AZ−4616−01 TCGA−AZ−4323−01 TCGA−AG−A036−01 TCGA−AG−A02X−01 TCGA−AG−A02N−01 TCGA−AG−A026−01 TCGA−AG−A020−01 TCGA−AG−A01Y−01 TCGA−AG−A01W−01 TCGA−AG−A01L−01 TCGA−AG−A014−01 TCGA−AG−A011−01 TCGA−AG−A00Y−01 TCGA−AG−A00C−01 TCGA−AG−4015−01 TCGA−AG−4008−01 TCGA−AG−4007−01 TCGA−AG−4005−01 TCGA−AG−3999−01 TCGA−AG−3902−01 TCGA−AG−3898−01 TCGA−AG−3893−01 TCGA−AG−3890−01 TCGA−AG−3882−01 TCGA−AG−3726−01 TCGA−AG−3612−01 TCGA−AG−3611−01 TCGA−AG−3609−01 TCGA−AG−3608−01 TCGA−AG−3605−01 TCGA−AG−3602−01 TCGA−AG−3598−01 TCGA−AG−3594−01 TCGA−AG−3587−01 TCGA−AG−3581−01 TCGA−AG−3578−01 TCGA−AG−3575−01 TCGA−AF−6136−01 TCGA−AF−4110−01 TCGA−AF−3913−01 TCGA−AF−3400−01 TCGA−AF−2691−01 TCGA−AF−2689−01 TCGA−AD−6965−01 TCGA−AD−6888−01 TCGA−AA−A03J−01 TCGA−AA−A02W−01 TCGA−AA−A02H−01 TCGA−AA−A02F−01 TCGA−AA−A01Z−01 TCGA−AA−A01S−01 TCGA−AA−A01K−01 TCGA−AA−A01G−01 TCGA−AA−A01F−01 TCGA−AA−A01D−01 TCGA−AA−A00W−01 TCGA−AA−A00L−01 TCGA−AA−A00F−01 TCGA−AA−A00D−01 TCGA−AA−3982−01 TCGA−AA−3979−01 TCGA−AA−3976−01 TCGA−AA−3975−01 TCGA−AA−3956−01 TCGA−AA−3930−01 TCGA−AA−3875−01 TCGA−AA−3869−01 TCGA−AA−3867−01 TCGA−AA−3866−01 TCGA−AA−3858−01 TCGA−AA−3856−01 TCGA−AA−3851−01 TCGA−AA−3848−01 TCGA−AA−3844−01 TCGA−AA−3842−01 TCGA−AA−3693−01 TCGA−AA−3681−01 TCGA−AA−3666−01 TCGA−AA−3562−01 TCGA−AA−3561−01 TCGA−AA−3560−01 TCGA−AA−3558−01 TCGA−AA−3556−01 TCGA−AA−3553−01 TCGA−AA−3549−01 TCGA−AA−3542−01 TCGA−AA−3531−01 TCGA−AA−3526−01 TCGA−AA−3524−01 TCGA−AA−3520−01 TCGA−AA−3519−01 TCGA−AA−3517−01 TCGA−A6−6137−01 TCGA−A6−5662−01 TCGA−A6−5659−01 TCGA−A6−3810−01 TCGA−A6−2683−01 TCGA−A6−2674−01 TCGA−A6−2670−01

TCGA−DC−6683−01 TCGA−AA−A01R−01 TCGA−AA−3516−01 TCGA−AA−3712−01 TCGA−AA−3980−01 TCGA−AA−3663−01 TCGA−AA−3994−01 TCGA−AA−3864−01 TCGA−AA−3492−01 TCGA−CA−6718−01 TCGA−AA−3984−01 TCGA−AA−3877−01 TCGA−A6−6781−01 TCGA−DM−A28K−01 TCGA−A6−5660−01 TCGA−A6−5659−01 TCGA−AZ−4315−01 TCGA−CM−5861−01 TCGA−CA−5254−01 TCGA−AA−A022−01 TCGA−AA−3821−01 TCGA−A6−6653−01 TCGA−D5−6928−01 TCGA−AG−A025−01 TCGA−AG−3892−01 TCGA−AA−3693−01 TCGA−AA−A00J−01 TCGA−G4−6307−01 TCGA−CK−5913−01 TCGA−CK−5912−01 TCGA−A6−6648−01 TCGA−G4−6628−01 TCGA−AA−A00R−01 TCGA−AA−3977−01 TCGA−G4−6626−01 TCGA−F4−6569−01 TCGA−D5−6536−01 TCGA−CM−6168−01 TCGA−CA−6717−01 TCGA−CM−4743−01 TCGA−CK−4952−01 TCGA−AU−6004−01 TCGA−AD−6895−01 TCGA−AA−A010−01 TCGA−G4−6306−01 TCGA−G4−6293−01 TCGA−F4−6570−01 TCGA−DM−A28C−01 TCGA−D5−6927−01 TCGA−D5−6540−01 TCGA−CM−6162−01 TCGA−CM−5348−01 TCGA−AZ−6599−01 TCGA−AZ−6598−01 TCGA−AY−6197−01 TCGA−AG−A002−01 TCGA−AA−3713−01 TCGA−AA−3662−01 TCGA−AA−3510−01 TCGA−A6−5661−01 TCGA−G4−6625−01 TCGA−G4−6588−01 TCGA−G4−6586−01 TCGA−G4−6323−01 TCGA−G4−6321−01 TCGA−G4−6317−01 TCGA−G4−6315−01 TCGA−G4−6304−01 TCGA−G4−6299−01 TCGA−F5−6812−01 TCGA−F5−6464−01 TCGA−F4−6806−01 TCGA−EI−6510−01 TCGA−DY−A1H8−01 TCGA−DY−A0XA−01 TCGA−DM−A28H−01 TCGA−DM−A28G−01 TCGA−DM−A28F−01 TCGA−DM−A1D4−01 TCGA−DM−A0XD−01 TCGA−D5−7000−01 TCGA−D5−6932−01 TCGA−D5−6923−01 TCGA−D5−6898−01 TCGA−D5−6539−01 TCGA−D5−6535−01 TCGA−D5−6534−01 TCGA−D5−6533−01 TCGA−D5−6532−01 TCGA−D5−5539−01 TCGA−D5−5538−01 TCGA−CM−6678−01 TCGA−CM−6676−01 TCGA−CM−6674−01 TCGA−CM−6172−01 TCGA−CM−6171−01 TCGA−CM−6169−01 TCGA−CM−6165−01 TCGA−CM−6161−01 TCGA−CM−5860−01 TCGA−CM−5349−01 TCGA−CM−5344−01 TCGA−CM−5341−01 TCGA−CM−4752−01 TCGA−CM−4747−01 TCGA−CK−4950−01 TCGA−CI−6620−01 TCGA−CI−6619−01 TCGA−CA−6719−01 TCGA−CA−5797−01 TCGA−AZ−6603−01 TCGA−AZ−6601−01 TCGA−AZ−6600−01 TCGA−AZ−4323−01 TCGA−AU−3779−01 TCGA−AH−6549−01 TCGA−AG−3881−01 TCGA−AG−3742−01 TCGA−AF−6672−01 TCGA−AF−4110−01 TCGA−AF−2693−01 TCGA−AD−6901−01 TCGA−AD−6889−01 TCGA−AA−3968−01 TCGA−AA−3811−01 TCGA−AA−3715−01 TCGA−AA−3697−01 TCGA−AA−3655−01 TCGA−AA−3502−01 TCGA−AA−3496−01 TCGA−A6−6780−01 TCGA−A6−6652−01 TCGA−A6−6649−01 TCGA−A6−6142−01 TCGA−A6−6141−01 TCGA−A6−5666−01 TCGA−A6−5665−01 TCGA−A6−5662−01 TCGA−A6−4105−01

P53 Pathway FDR = 1.9e−12%, FDR nod = 0.0042% Inhibition Of Replication Initiation Of Damaged DNA By RB1/E2F1 FDR = 2e−12%, FDR nod = 2.3e−11%

TP53 RB1

CREBBP POLA1


TFDP1

wt wt

EP300

POLA2

ATR

PPP2R3B

CDK2

PPP2CA

KAT2B

PRIM1

AKT1

PRIM2

MDM2

PPP2CB

MDM4

PPP2R1B

PPP2CA

known HCG mut

wt

TP53 ATM HERC2 ATR BLM CLSPN RAD50 BARD1 BRE CCNA1 CHEK2 RNF168 RPA1 BRCA1 CDK2 HIST1H2BE HIST1H2BG HIST1H2BH HUS1 TOP3A TOPBP1 ATRIP BABAM1 BRCC3 BRIP1 CCNA2 CHEK1 DNA2 EXO1 FAM175A H2AFX HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BF HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BO HIST1H4A HIST1H4B HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4L HIST2H2BE HIST3H2BB HIST3H3 HIST4H4 KAT5 MDC1 MRE11A NBN PIAS4 PPP4C PPP4R2 RAD1 RAD17 RAD9A RAD9B RBBP8 RFC2 RFC4 RFC5 RMI1 RMI2 RNF4 RNF8 RPA2 RPA3 SIRT6 TIMELESS TIPIN TP53BP1 UBA52 UBC UBE2I UBE2N UBE2V2 UIMC1 WHSC1 WRN

CCNH

CDC25A

known HCG mut

CDKN1B

wt WEE1

MYC

CCNE1

CDK2

PKMYT1

CDK7

CDKN1A

MAX

CCNE2

MNAT1

wt TFDP1

CDKN1B

CDC25B

known HCG mut RBL1 known HCG mut

unknown CG mut

RB1

G2/M DNA Damage Checkpoint Processing Of DNA Double Strand Break Ends FDR = 1.9e−12%, FDR nod = 4.6%

Cyclin E Associated Events During G1/S Transition FDR = 1.9e−12%, FDR nod = 2.3e−11%

known HCG mut ATM known HCG mut PPP2R1A

PPP2R1A CCNA1

unknown CG mut RB1 unknown CG mut

CUL1

E2F5

E2F2

CCND3 CDK7

MNAT1 SKP1

CDKN1A CKS1B

PPP2CB

PPP2R2A

TCGA−AA−3833−01 TCGA−CM−4747−01 TCGA−AA−3994−01 TCGA−DC−6160−01 TCGA−CA−5255−01 TCGA−AA−3543−01 TCGA−A6−6648−01 TCGA−CA−5796−01 TCGA−AY−6386−01 TCGA−AA−A00R−01 TCGA−AA−A00J−01 TCGA−AA−3554−01 TCGA−AA−3864−01 TCGA−AA−3715−01 TCGA−D5−5537−01 TCGA−AH−6549−01 TCGA−AA−3877−01 TCGA−CM−5344−01 TCGA−AD−6964−01 TCGA−AA−A029−01 TCGA−AA−3973−01 TCGA−AA−3947−01 TCGA−AA−3818−01 TCGA−AA−3672−01 TCGA−AG−A002−01 TCGA−A6−6781−01 TCGA−G4−6588−01 TCGA−AA−A00N−01 TCGA−AA−3516−01 TCGA−CM−5861−01 TCGA−CK−6751−01 TCGA−AZ−4315−01 TCGA−AD−6889−01 TCGA−AA−3984−01 TCGA−A6−6653−01 TCGA−A6−6141−01 TCGA−G5−6641−01 TCGA−D5−6536−01 TCGA−CM−6680−01 TCGA−CK−6746−01 TCGA−CK−5913−01 TCGA−CK−5912−01 TCGA−AG−3892−01 TCGA−AA−A022−01 TCGA−AA−3966−01 TCGA−AA−3664−01 TCGA−AA−3555−01 TCGA−AA−3527−01 TCGA−AA−3518−01 TCGA−AA−3510−01 TCGA−AA−3502−01 TCGA−AA−3496−01 TCGA−A6−6780−01 TCGA−A6−5661−01 TCGA−G4−6309−01 TCGA−F4−6809−01 TCGA−F4−6570−01 TCGA−DY−A1H8−01 TCGA−DM−A28G−01 TCGA−DM−A28C−01 TCGA−D5−7000−01 TCGA−D5−6928−01 TCGA−D5−6537−01 TCGA−D5−6529−01 TCGA−D5−5539−01 TCGA−CM−6170−01 TCGA−CK−6748−01 TCGA−CA−6715−01 TCGA−AZ−6603−01 TCGA−AZ−4682−01 TCGA−AG−3727−01 TCGA−AG−3600−01 TCGA−AD−6890−01 TCGA−AA−A02Y−01 TCGA−AA−A01R−01 TCGA−AA−3950−01 TCGA−AA−3861−01 TCGA−AA−3819−01 TCGA−AA−3710−01 TCGA−AA−3678−01 TCGA−AA−3530−01 TCGA−AA−3522−01 TCGA−A6−5664−01 TCGA−A6−5660−01 TCGA−AA−A010−01 TCGA−CA−6717−01 TCGA−CM−4743−01 TCGA−G4−6628−01 TCGA−G4−6586−01 TCGA−G4−6304−01 TCGA−G4−6293−01 TCGA−F4−6808−01 TCGA−EI−6507−01 TCGA−DM−A28H−01 TCGA−D5−5538−01 TCGA−CM−6171−01 TCGA−CM−5349−01 TCGA−AZ−6608−01 TCGA−AZ−6599−01 TCGA−AU−6004−01 TCGA−AA−3977−01 TCGA−AA−3811−01 TCGA−AA−3713−01 TCGA−AA−3662−01 TCGA−AA−3492−01 TCGA−A6−5665−01 TCGA−G5−6235−01 TCGA−G4−6315−01 TCGA−G4−6307−01 TCGA−G4−6306−01 TCGA−F5−6813−01 TCGA−EI−6510−01 TCGA−EF−5830−01 TCGA−DM−A1DB−01 TCGA−DM−A1DA−01 TCGA−DC−5337−01 TCGA−D5−6931−01 TCGA−D5−6923−01 TCGA−D5−6540−01 TCGA−D5−6539−01 TCGA−D5−6535−01 TCGA−CM−6164−01 TCGA−CM−5868−01 TCGA−CM−5864−01 TCGA−CM−4752−01 TCGA−CL−5917−01 TCGA−CK−4952−01 TCGA−CA−6718−01 TCGA−AZ−6601−01 TCGA−AZ−6598−01 TCGA−AY−6197−01 TCGA−AU−3779−01 TCGA−AH−6643−01 TCGA−AH−6544−01 TCGA−AG−3731−01 TCGA−AD−6963−01 TCGA−AD−6901−01 TCGA−AA−3663−01 TCGA−AA−3655−01 TCGA−G4−6625−01 TCGA−G4−6323−01 TCGA−G4−6321−01 TCGA−G4−6317−01 TCGA−G4−6299−01 TCGA−F5−6812−01 TCGA−F5−6702−01 TCGA−F4−6856−01 TCGA−F4−6854−01 TCGA−F4−6807−01 TCGA−F4−6806−01 TCGA−F4−6460−01 TCGA−EI−6508−01 TCGA−EI−6506−01 TCGA−DY−A1DF−01 TCGA−DY−A1DC−01 TCGA−DM−A28K−01 TCGA−DM−A28F−01 TCGA−DM−A28E−01 TCGA−DM−A285−01 TCGA−DM−A1HA−01 TCGA−DM−A1D8−01 TCGA−DM−A1D7−01 TCGA−DM−A1D4−01 TCGA−DM−A1D0−01 TCGA−DM−A0XF−01 TCGA−DC−6683−01 TCGA−DC−6682−01 TCGA−DC−6155−01 TCGA−D5−6929−01 TCGA−D5−6924−01 TCGA−D5−6920−01 TCGA−D5−6898−01 TCGA−D5−6541−01 TCGA−D5−6538−01 TCGA−D5−6533−01 TCGA−D5−6532−01 TCGA−D5−5540−01 TCGA−CM−6679−01 TCGA−CM−6677−01 TCGA−CM−6675−01 TCGA−CM−6172−01 TCGA−CM−6168−01 TCGA−CM−6166−01 TCGA−CM−6165−01 TCGA−CM−6163−01 TCGA−CM−6162−01 TCGA−CM−5862−01 TCGA−CM−5860−01 TCGA−CM−5348−01 TCGA−CK−5916−01 TCGA−CK−5914−01 TCGA−CK−4948−01 TCGA−CK−4947−01 TCGA−CI−6620−01 TCGA−CI−6619−01 TCGA−CA−6719−01 TCGA−AZ−6605−01 TCGA−AZ−6600−01 TCGA−AZ−5407−01 TCGA−AZ−5403−01 TCGA−AY−6196−01 TCGA−AY−5543−01 TCGA−AY−4070−01 TCGA−AG−A02N−01 TCGA−AG−3885−01 TCGA−AG−3742−01 TCGA−AG−3732−01 TCGA−AF−6655−01 TCGA−AF−6136−01 TCGA−AF−2693−01 TCGA−AF−2687−01 TCGA−AD−6899−01 TCGA−AD−6548−01 TCGA−AD−5900−01 TCGA−AA−A01G−01 TCGA−AA−A00E−01 TCGA−AA−3860−01 TCGA−AA−3815−01 TCGA−AA−3697−01 TCGA−AA−3679−01 TCGA−AA−3660−01 TCGA−A6−6782−01 TCGA−A6−5659−01 TCGA−A6−4105−01 TCGA−A6−2676−01 TCGA−G4−6626−01 TCGA−G4−6310−01 TCGA−G4−6303−01 TCGA−F5−6571−01 TCGA−F5−6464−01 TCGA−F4−6805−01 TCGA−F4−6704−01 TCGA−F4−6703−01 TCGA−F4−6459−01 TCGA−DY−A1DG−01 TCGA−DY−A1DD−01 TCGA−DY−A0XA−01 TCGA−DT−5265−01 TCGA−DM−A1D9−01 TCGA−DM−A1D6−01 TCGA−DM−A0XD−01 TCGA−DC−6158−01 TCGA−DC−6157−01 TCGA−DC−5869−01 TCGA−D5−6932−01 TCGA−D5−6930−01 TCGA−D5−6927−01 TCGA−D5−6926−01 TCGA−D5−6922−01 TCGA−D5−5541−01 TCGA−CM−6676−01 TCGA−CM−6169−01 TCGA−CM−6161−01 TCGA−CM−5341−01 TCGA−CM−4746−01 TCGA−CM−4744−01 TCGA−CL−5918−01 TCGA−CK−4950−01 TCGA−CI−6624−01 TCGA−CI−6622−01 TCGA−CI−6621−01 TCGA−CA−6716−01 TCGA−CA−5797−01 TCGA−AZ−6607−01 TCGA−AZ−4616−01 TCGA−AZ−4323−01 TCGA−AY−4071−01 TCGA−AG−A036−01 TCGA−AG−A032−01 TCGA−AG−A02X−01 TCGA−AG−A026−01 TCGA−AG−A020−01 TCGA−AG−A01Y−01 TCGA−AG−A01W−01 TCGA−AG−A01L−01 TCGA−AG−A016−01 TCGA−AG−A014−01 TCGA−AG−A011−01 TCGA−AG−A00Y−01 TCGA−AG−A00C−01 TCGA−AG−4015−01 TCGA−AG−4008−01 TCGA−AG−4007−01 TCGA−AG−4005−01 TCGA−AG−3999−01 TCGA−AG−3909−01 TCGA−AG−3902−01 TCGA−AG−3898−01 TCGA−AG−3896−01 TCGA−AG−3893−01 TCGA−AG−3890−01 TCGA−AG−3882−01 TCGA−AG−3726−01 TCGA−AG−3612−01 TCGA−AG−3611−01 TCGA−AG−3609−01 TCGA−AG−3608−01 TCGA−AG−3605−01 TCGA−AG−3602−01 TCGA−AG−3601−01 TCGA−AG−3598−01 TCGA−AG−3594−01 TCGA−AG−3587−01 TCGA−AG−3581−01 TCGA−AG−3578−01 TCGA−AG−3575−01 TCGA−AF−6672−01 TCGA−AF−4110−01 TCGA−AF−3913−01 TCGA−AF−3400−01 TCGA−AF−2691−01 TCGA−AF−2689−01 TCGA−AD−6965−01 TCGA−AD−6888−01 TCGA−AA−A03J−01 TCGA−AA−A02W−01 TCGA−AA−A02J−01 TCGA−AA−A02H−01 TCGA−AA−A02F−01 TCGA−AA−A01Z−01 TCGA−AA−A01T−01 TCGA−AA−A01S−01 TCGA−AA−A01K−01 TCGA−AA−A01F−01 TCGA−AA−A01D−01 TCGA−AA−A00W−01 TCGA−AA−A00L−01 TCGA−AA−A00F−01 TCGA−AA−A00D−01 TCGA−AA−3982−01 TCGA−AA−3980−01 TCGA−AA−3979−01 TCGA−AA−3976−01 TCGA−AA−3975−01 TCGA−AA−3972−01 TCGA−AA−3956−01 TCGA−AA−3949−01 TCGA−AA−3930−01 TCGA−AA−3875−01 TCGA−AA−3869−01 TCGA−AA−3867−01 TCGA−AA−3866−01 TCGA−AA−3858−01 TCGA−AA−3856−01 TCGA−AA−3851−01 TCGA−AA−3848−01 TCGA−AA−3844−01 TCGA−AA−3842−01 TCGA−AA−3814−01 TCGA−AA−3712−01 TCGA−AA−3693−01 TCGA−AA−3685−01 TCGA−AA−3681−01 TCGA−AA−3667−01 TCGA−AA−3666−01 TCGA−AA−3562−01 TCGA−AA−3561−01 TCGA−AA−3560−01 TCGA−AA−3558−01 TCGA−AA−3556−01 TCGA−AA−3553−01 TCGA−AA−3552−01 TCGA−AA−3549−01 TCGA−AA−3542−01 TCGA−AA−3531−01 TCGA−AA−3526−01 TCGA−AA−3524−01 TCGA−AA−3520−01 TCGA−AA−3519−01 TCGA−AA−3517−01 TCGA−AA−3511−01 TCGA−A6−6654−01 TCGA−A6−6652−01 TCGA−A6−6651−01 TCGA−A6−6649−01 TCGA−A6−6142−01 TCGA−A6−6138−01 TCGA−A6−6137−01 TCGA−A6−5662−01 TCGA−A6−5656−01 TCGA−A6−3810−01 TCGA−A6−3807−01 TCGA−A6−2683−01 TCGA−A6−2678−01 TCGA−A6−2674−01 TCGA−A6−2670−01

TCGA−AZ−4315−01 TCGA−AA−A00N−01 TCGA−AA−3975−01 TCGA−CK−5913−01 TCGA−AA−3712−01 TCGA−AA−3516−01 TCGA−A6−6781−01 TCGA−G4−6309−01 TCGA−CK−5916−01 TCGA−AD−6964−01 TCGA−DC−6157−01 TCGA−CA−6718−01 TCGA−AA−3554−01 TCGA−AA−A01Q−01 TCGA−DM−A1D0−01 TCGA−AA−A022−01 TCGA−AA−3950−01 TCGA−A6−5656−01 TCGA−CK−6746−01 TCGA−AG−3892−01 TCGA−DY−A1DC−01 TCGA−AG−3898−01 TCGA−AG−3609−01 TCGA−AF−5654−01 TCGA−AA−3984−01 TCGA−AA−3947−01 TCGA−AA−3848−01 TCGA−AZ−5407−01 TCGA−AA−A02O−01 TCGA−G4−6626−01 TCGA−D5−6928−01 TCGA−AD−5900−01 TCGA−AA−A01R−01 TCGA−AA−3846−01 TCGA−AA−3663−01 TCGA−AA−3514−01 TCGA−A6−6653−01 TCGA−G4−6588−01 TCGA−AA−A010−01 TCGA−D5−6540−01 TCGA−CK−4952−01 TCGA−AG−A002−01 TCGA−AA−3510−01 TCGA−CM−6678−01 TCGA−CM−6161−01 TCGA−CM−4743−01 TCGA−AZ−6601−01 TCGA−AY−6197−01 TCGA−AU−6004−01 TCGA−AA−3715−01 TCGA−AA−3713−01 TCGA−A6−5665−01 TCGA−A6−4105−01 TCGA−G4−6625−01 TCGA−G4−6586−01 TCGA−G4−6323−01 TCGA−G4−6321−01 TCGA−G4−6317−01 TCGA−G4−6315−01 TCGA−G4−6306−01 TCGA−G4−6304−01 TCGA−G4−6299−01 TCGA−G4−6293−01 TCGA−F5−6812−01 TCGA−F5−6464−01 TCGA−F4−6806−01 TCGA−F4−6570−01 TCGA−EI−6510−01 TCGA−DY−A1H8−01 TCGA−DY−A0XA−01 TCGA−DM−A28H−01 TCGA−DM−A28G−01 TCGA−DM−A28F−01 TCGA−DM−A28C−01 TCGA−DM−A1D4−01 TCGA−DM−A0XD−01 TCGA−D5−7000−01 TCGA−D5−6932−01 TCGA−D5−6927−01 TCGA−D5−6923−01 TCGA−D5−6898−01 TCGA−D5−6539−01 TCGA−D5−6535−01 TCGA−D5−6534−01 TCGA−D5−6533−01 TCGA−D5−6532−01 TCGA−D5−5539−01 TCGA−D5−5538−01 TCGA−CM−6676−01 TCGA−CM−6674−01 TCGA−CM−6172−01 TCGA−CM−6171−01 TCGA−CM−6169−01 TCGA−CM−6165−01 TCGA−CM−6162−01 TCGA−CM−5860−01 TCGA−CM−5349−01 TCGA−CM−5348−01 TCGA−CM−5344−01 TCGA−CM−5341−01 TCGA−CM−4752−01 TCGA−CM−4747−01 TCGA−CK−4950−01 TCGA−CI−6620−01 TCGA−CI−6619−01 TCGA−CA−6719−01 TCGA−CA−6717−01 TCGA−CA−5797−01 TCGA−AZ−6603−01 TCGA−AZ−6600−01 TCGA−AZ−6599−01 TCGA−AZ−6598−01 TCGA−AZ−4323−01 TCGA−AU−3779−01 TCGA−AH−6549−01 TCGA−AG−3881−01 TCGA−AG−3742−01 TCGA−AF−6672−01 TCGA−AF−4110−01 TCGA−AF−2693−01 TCGA−AD−6901−01 TCGA−AD−6895−01 TCGA−AD−6889−01 TCGA−AA−3968−01 TCGA−AA−3811−01 TCGA−AA−3697−01 TCGA−AA−3662−01 TCGA−AA−3655−01 TCGA−AA−3502−01 TCGA−AA−3496−01 TCGA−A6−6780−01 TCGA−A6−6652−01 TCGA−A6−6649−01 TCGA−A6−6142−01 TCGA−A6−6141−01 TCGA−A6−5666−01 TCGA−A6−5662−01 TCGA−A6−5661−01

Senescence And Autophagy In Cancer FDR = 1.9e−12%, FDR nod = 0.72% P53 Pathway Feedback Loops 2 FDR = 1.9e−12%, FDR nod = 6.9e−07%

TCGA−D5−6928−01 TCGA−AA−3831−01 TCGA−AA−A03F−01 TCGA−AA−3502−01 TCGA−A6−2672−01 TCGA−F4−6570−01 TCGA−AA−3710−01 TCGA−G4−6309−01 TCGA−DM−A282−01 TCGA−AG−A002−01 TCGA−AG−3892−01 TCGA−AA−A00K−01 TCGA−AA−3984−01 TCGA−AA−3877−01 TCGA−AA−3854−01 TCGA−AA−3821−01 TCGA−AA−3715−01 TCGA−AA−3555−01 TCGA−A6−6781−01 TCGA−A6−6141−01 TCGA−A6−5666−01 TCGA−AA−3663−01 TCGA−G4−6586−01 TCGA−DM−A28K−01 TCGA−DM−A1D4−01 TCGA−AA−A010−01 TCGA−AA−3949−01 TCGA−G4−6307−01 TCGA−F4−6806−01 TCGA−EF−5830−01 TCGA−DY−A1DD−01 TCGA−DT−5265−01 TCGA−DC−5869−01 TCGA−D5−6927−01 TCGA−CM−6172−01 TCGA−CM−6164−01 TCGA−CM−6161−01 TCGA−CM−4752−01 TCGA−CK−4950−01 TCGA−CA−6717−01 TCGA−CA−6716−01 TCGA−AZ−6601−01 TCGA−AZ−6598−01 TCGA−AY−6197−01 TCGA−AY−5543−01 TCGA−AU−6004−01 TCGA−AF−3913−01 TCGA−AA−A01F−01 TCGA−AA−3980−01 TCGA−AA−3956−01 TCGA−AA−3867−01 TCGA−AA−3713−01 TCGA−AA−3666−01 TCGA−A6−6651−01 TCGA−A6−4105−01 TCGA−G5−6235−01 TCGA−G4−6628−01 TCGA−G4−6626−01 TCGA−G4−6625−01 TCGA−G4−6323−01 TCGA−G4−6321−01 TCGA−G4−6317−01 TCGA−G4−6315−01 TCGA−G4−6310−01 TCGA−G4−6306−01 TCGA−G4−6304−01 TCGA−G4−6303−01 TCGA−G4−6299−01 TCGA−G4−6293−01 TCGA−F5−6813−01 TCGA−F5−6812−01 TCGA−F5−6702−01 TCGA−F5−6571−01 TCGA−F5−6464−01 TCGA−F4−6856−01 TCGA−F4−6854−01 TCGA−F4−6808−01 TCGA−F4−6807−01 TCGA−F4−6805−01 TCGA−F4−6704−01 TCGA−F4−6703−01 TCGA−F4−6460−01 TCGA−F4−6459−01 TCGA−EI−6510−01 TCGA−EI−6508−01 TCGA−EI−6507−01 TCGA−EI−6506−01 TCGA−DY−A1DG−01 TCGA−DY−A1DF−01 TCGA−DY−A1DC−01 TCGA−DY−A0XA−01 TCGA−DM−A28H−01 TCGA−DM−A28F−01 TCGA−DM−A28E−01 TCGA−DM−A285−01 TCGA−DM−A1HA−01 TCGA−DM−A1DB−01 TCGA−DM−A1DA−01 TCGA−DM−A1D9−01 TCGA−DM−A1D8−01 TCGA−DM−A1D7−01 TCGA−DM−A1D6−01 TCGA−DM−A1D0−01 TCGA−DM−A0XF−01 TCGA−DM−A0XD−01 TCGA−DC−6683−01 TCGA−DC−6682−01 TCGA−DC−6158−01 TCGA−DC−6157−01 TCGA−DC−6155−01 TCGA−DC−5337−01 TCGA−D5−6932−01 TCGA−D5−6931−01 TCGA−D5−6930−01 TCGA−D5−6929−01 TCGA−D5−6926−01 TCGA−D5−6924−01 TCGA−D5−6923−01 TCGA−D5−6922−01 TCGA−D5−6920−01 TCGA−D5−6898−01 TCGA−D5−6541−01 TCGA−D5−6540−01 TCGA−D5−6539−01 TCGA−D5−6538−01 TCGA−D5−6535−01 TCGA−D5−6533−01 TCGA−D5−6532−01 TCGA−D5−5541−01 TCGA−D5−5540−01 TCGA−D5−5538−01 TCGA−CM−6679−01 TCGA−CM−6677−01 TCGA−CM−6676−01 TCGA−CM−6675−01 TCGA−CM−6171−01 TCGA−CM−6169−01 TCGA−CM−6168−01 TCGA−CM−6166−01 TCGA−CM−6165−01 TCGA−CM−6163−01 TCGA−CM−6162−01 TCGA−CM−5868−01 TCGA−CM−5864−01 TCGA−CM−5862−01 TCGA−CM−5860−01 TCGA−CM−5349−01 TCGA−CM−5348−01 TCGA−CM−5341−01 TCGA−CM−4746−01 TCGA−CM−4744−01 TCGA−CM−4743−01 TCGA−CL−5918−01 TCGA−CL−5917−01 TCGA−CK−5916−01 TCGA−CK−5914−01 TCGA−CK−4952−01 TCGA−CK−4948−01 TCGA−CK−4947−01 TCGA−CI−6624−01 TCGA−CI−6622−01 TCGA−CI−6621−01 TCGA−CI−6620−01 TCGA−CI−6619−01 TCGA−CA−6719−01 TCGA−CA−6718−01 TCGA−CA−5797−01 TCGA−AZ−6608−01 TCGA−AZ−6607−01 TCGA−AZ−6605−01 TCGA−AZ−6600−01 TCGA−AZ−6599−01 TCGA−AZ−5407−01 TCGA−AZ−5403−01 TCGA−AZ−4616−01 TCGA−AZ−4323−01 TCGA−AY−6196−01 TCGA−AY−4071−01 TCGA−AY−4070−01 TCGA−AU−3779−01 TCGA−AH−6643−01 TCGA−AH−6544−01 TCGA−AG−A036−01 TCGA−AG−A032−01 TCGA−AG−A02X−01 TCGA−AG−A02N−01 TCGA−AG−A026−01 TCGA−AG−A020−01 TCGA−AG−A01Y−01 TCGA−AG−A01W−01 TCGA−AG−A01L−01 TCGA−AG−A016−01 TCGA−AG−A014−01 TCGA−AG−A011−01 TCGA−AG−A00Y−01 TCGA−AG−A00C−01 TCGA−AG−4015−01 TCGA−AG−4008−01 TCGA−AG−4007−01 TCGA−AG−4005−01 TCGA−AG−3999−01 TCGA−AG−3909−01 TCGA−AG−3902−01 TCGA−AG−3898−01 TCGA−AG−3896−01 TCGA−AG−3893−01 TCGA−AG−3890−01 TCGA−AG−3885−01 TCGA−AG−3882−01 TCGA−AG−3742−01 TCGA−AG−3732−01 TCGA−AG−3731−01 TCGA−AG−3726−01 TCGA−AG−3612−01 TCGA−AG−3611−01 TCGA−AG−3609−01 TCGA−AG−3608−01 TCGA−AG−3605−01 TCGA−AG−3602−01 TCGA−AG−3601−01 TCGA−AG−3598−01 TCGA−AG−3594−01 TCGA−AG−3587−01 TCGA−AG−3581−01 TCGA−AG−3578−01 TCGA−AG−3575−01 TCGA−AF−6672−01 TCGA−AF−6655−01 TCGA−AF−6136−01 TCGA−AF−4110−01 TCGA−AF−3400−01 TCGA−AF−2693−01 TCGA−AF−2691−01 TCGA−AF−2689−01 TCGA−AF−2687−01 TCGA−AD−6965−01 TCGA−AD−6963−01 TCGA−AD−6901−01 TCGA−AD−6899−01 TCGA−AD−6888−01 TCGA−AD−6548−01 TCGA−AD−5900−01 TCGA−AA−A03J−01 TCGA−AA−A02W−01 TCGA−AA−A02J−01 TCGA−AA−A02H−01 TCGA−AA−A02F−01 TCGA−AA−A01Z−01 TCGA−AA−A01T−01 TCGA−AA−A01S−01 TCGA−AA−A01K−01 TCGA−AA−A01G−01 TCGA−AA−A01D−01 TCGA−AA−A00W−01 TCGA−AA−A00L−01 TCGA−AA−A00F−01 TCGA−AA−A00E−01 TCGA−AA−A00D−01 TCGA−AA−3982−01 TCGA−AA−3979−01 TCGA−AA−3977−01 TCGA−AA−3976−01 TCGA−AA−3975−01 TCGA−AA−3972−01 TCGA−AA−3930−01 TCGA−AA−3875−01 TCGA−AA−3869−01 TCGA−AA−3866−01 TCGA−AA−3860−01 TCGA−AA−3858−01 TCGA−AA−3856−01 TCGA−AA−3851−01 TCGA−AA−3848−01 TCGA−AA−3844−01 TCGA−AA−3842−01 TCGA−AA−3815−01 TCGA−AA−3814−01 TCGA−AA−3811−01 TCGA−AA−3712−01 TCGA−AA−3697−01 TCGA−AA−3693−01 TCGA−AA−3685−01 TCGA−AA−3681−01 TCGA−AA−3679−01 TCGA−AA−3667−01 TCGA−AA−3662−01 TCGA−AA−3660−01 TCGA−AA−3655−01 TCGA−AA−3562−01 TCGA−AA−3561−01 TCGA−AA−3560−01 TCGA−AA−3558−01 TCGA−AA−3556−01 TCGA−AA−3553−01 TCGA−AA−3552−01 TCGA−AA−3549−01 TCGA−AA−3542−01 TCGA−AA−3531−01 TCGA−AA−3526−01 TCGA−AA−3524−01 TCGA−AA−3520−01 TCGA−AA−3519−01 TCGA−AA−3517−01 TCGA−AA−3511−01 TCGA−AA−3492−01 TCGA−A6−6782−01 TCGA−A6−6654−01 TCGA−A6−6652−01 TCGA−A6−6649−01 TCGA−A6−6142−01 TCGA−A6−6138−01 TCGA−A6−6137−01 TCGA−A6−5665−01 TCGA−A6−5662−01 TCGA−A6−5659−01 TCGA−A6−5656−01 TCGA−A6−3810−01 TCGA−A6−3807−01 TCGA−A6−2683−01 TCGA−A6−2678−01 TCGA−A6−2676−01 TCGA−A6−2674−01 TCGA−A6−2670−01

TCGA−AA−A00R−01 TCGA−AG−4001−01 TCGA−AG−3574−01 TCGA−AA−3845−01 TCGA−AA−3543−01 TCGA−AA−A00O−01 TCGA−AA−3672−01 TCGA−AA−3833−01 TCGA−AA−3525−01 TCGA−AA−A00J−01 TCGA−AA−3554−01 TCGA−AG−3883−01 TCGA−AA−3821−01 TCGA−AG−3894−01 TCGA−AA−A024−01 TCGA−AA−3973−01 TCGA−AG−3881−01 TCGA−AA−3534−01 TCGA−AA−A00U−01 TCGA−AA−3831−01 TCGA−AA−3947−01 TCGA−AA−3877−01 TCGA−AA−A01V−01 TCGA−AA−3850−01 TCGA−AA−3812−01 TCGA−AA−3489−01 TCGA−CM−5344−01 TCGA−D5−6534−01 TCGA−CK−5915−01 TCGA−AH−6549−01 TCGA−F5−6811−01 TCGA−F5−6465−01 TCGA−F4−6569−01 TCGA−AA−3968−01 TCGA−CM−6167−01 TCGA−CK−6747−01 TCGA−CA−5255−01 TCGA−AH−6547−01 TCGA−A6−6648−01 TCGA−A6−3809−01 TCGA−CA−5254−01 TCGA−AA−3692−01 TCGA−A6−2671−01 TCGA−AG−A002−01 TCGA−G4−6588−01 TCGA−A6−6781−01 TCGA−AA−3984−01 TCGA−AA−3516−01 TCGA−A6−6780−01 TCGA−F4−6570−01 TCGA−AA−3496−01 TCGA−A6−5660−01 TCGA−CK−6746−01 TCGA−AA−3510−01 TCGA−G4−6309−01 TCGA−DM−A28C−01 TCGA−CM−6680−01 TCGA−D5−6928−01 TCGA−CM−5861−01 TCGA−CK−5912−01 TCGA−F4−6809−01 TCGA−CK−6748−01 TCGA−CK−5913−01 TCGA−AZ−6603−01 TCGA−AZ−4682−01 TCGA−AA−A022−01 TCGA−AA−3950−01 TCGA−AA−3819−01 TCGA−AA−3664−01 TCGA−CM−6170−01 TCGA−CK−6751−01 TCGA−CA−6715−01 TCGA−AD−6890−01 TCGA−AA−3966−01 TCGA−AA−3710−01 TCGA−AA−3518−01 TCGA−G5−6641−01 TCGA−AG−3600−01 TCGA−AA−3861−01 TCGA−AA−3678−01 TCGA−AA−3527−01 TCGA−A6−5661−01 TCGA−AZ−4315−01 TCGA−CM−6674−01 TCGA−AA−3864−01 TCGA−A6−6141−01 TCGA−D5−6536−01 TCGA−AG−3892−01 TCGA−AD−6895−01 TCGA−AD−6889−01 TCGA−AA−A00N−01 TCGA−F4−6855−01 TCGA−DM−A28G−01 TCGA−D5−7000−01 TCGA−D5−6537−01 TCGA−D5−5539−01 TCGA−CM−4747−01 TCGA−AD−6964−01 TCGA−AA−A01R−01 TCGA−AA−3715−01 TCGA−AA−3502−01 TCGA−A6−5666−01 TCGA−DY−A1H8−01 TCGA−DC−6160−01 TCGA−D5−6529−01 TCGA−CM−6678−01 TCGA−AY−6386−01 TCGA−AA−3696−01 TCGA−A6−6653−01 TCGA−DM−A0X9−01 TCGA−AZ−6606−01 TCGA−AG−3901−01 TCGA−AA−A02Y−01 TCGA−AA−3555−01 TCGA−A6−5664−01 TCGA−A6−5657−01 TCGA−DM−A282−01 TCGA−D5−5537−01 TCGA−CA−5796−01 TCGA−AH−6644−01 TCGA−AG−A025−01 TCGA−AG−A00H−01 TCGA−AG−3887−01 TCGA−AG−3878−01 TCGA−AG−3727−01 TCGA−AF−5654−01 TCGA−AA−A03F−01 TCGA−AA−A02O−01 TCGA−AA−A01I−01 TCGA−AA−3994−01 TCGA−AA−3939−01 TCGA−AA−3854−01 TCGA−AA−3852−01 TCGA−AA−3837−01 TCGA−AA−3818−01 TCGA−AA−3695−01 TCGA−AA−3673−01 TCGA−AA−3530−01 TCGA−AA−3522−01 TCGA−A6−3808−01 TCGA−CM−5863−01 TCGA−AG−A015−01 TCGA−AG−A008−01 TCGA−AG−3599−01 TCGA−AG−3586−01 TCGA−AG−3583−01 TCGA−AG−3580−01 TCGA−AF−2692−01 TCGA−AA−A029−01 TCGA−AA−A01X−01 TCGA−AA−A00Q−01 TCGA−AA−A00K−01 TCGA−AA−A00A−01 TCGA−AA−3986−01 TCGA−AA−3941−01 TCGA−AA−3870−01 TCGA−AA−3680−01 TCGA−AA−3548−01 TCGA−AA−3532−01 TCGA−AA−3521−01 TCGA−CA−6717−01 TCGA−G4−6586−01 TCGA−G4−6315−01 TCGA−AZ−6601−01 TCGA−AZ−6598−01 TCGA−AA−A010−01 TCGA−CM−4743−01 TCGA−CA−6718−01 TCGA−A6−5665−01 TCGA−D5−6540−01 TCGA−AZ−6608−01 TCGA−AA−3977−01 TCGA−G4−6304−01 TCGA−DY−A0XA−01 TCGA−D5−6927−01 TCGA−CM−6171−01 TCGA−CK−4952−01 TCGA−AY−6197−01 TCGA−AA−3713−01 TCGA−AA−3663−01 TCGA−AA−3660−01 TCGA−G4−6293−01 TCGA−F4−6856−01 TCGA−EI−6507−01 TCGA−CM−4752−01 TCGA−AZ−6599−01 TCGA−AD−6901−01 TCGA−G4−6628−01 TCGA−G4−6317−01 TCGA−G4−6306−01 TCGA−F4−6854−01 TCGA−EI−6510−01 TCGA−DM−A1DB−01 TCGA−D5−6535−01 TCGA−D5−6533−01 TCGA−D5−6532−01 TCGA−D5−5538−01 TCGA−CM−6164−01 TCGA−CM−6162−01 TCGA−CM−5349−01 TCGA−CL−5917−01 TCGA−CK−4950−01 TCGA−AU−6004−01 TCGA−AA−3662−01 TCGA−AA−3655−01 TCGA−G4−6626−01 TCGA−G4−6625−01 TCGA−G4−6323−01 TCGA−G4−6307−01 TCGA−G4−6303−01 TCGA−F4−6808−01 TCGA−EF−5830−01 TCGA−DY−A1DF−01 TCGA−DM−A1D4−01 TCGA−DM−A0XD−01 TCGA−DC−5337−01 TCGA−D5−6923−01 TCGA−D5−6539−01 TCGA−D5−6538−01 TCGA−CM−6168−01 TCGA−CM−6161−01 TCGA−CM−5864−01 TCGA−CM−5862−01 TCGA−CM−5860−01 TCGA−CM−5348−01 TCGA−CK−5916−01 TCGA−AZ−5407−01 TCGA−AU−3779−01 TCGA−AF−2693−01 TCGA−AA−3811−01 TCGA−AA−3697−01 TCGA−AA−3492−01 TCGA−A6−4105−01 TCGA−G5−6235−01 TCGA−G4−6299−01 TCGA−F5−6813−01 TCGA−F5−6571−01 TCGA−F4−6807−01 TCGA−F4−6806−01 TCGA−F4−6703−01 TCGA−EI−6506−01 TCGA−DY−A1DG−01 TCGA−DM−A28K−01 TCGA−DM−A28H−01 TCGA−DM−A1D9−01 TCGA−DM−A0XF−01 TCGA−DC−6683−01 TCGA−D5−6932−01 TCGA−D5−6931−01 TCGA−D5−6898−01 TCGA−D5−6541−01 TCGA−CM−6172−01 TCGA−CM−6166−01 TCGA−CM−4746−01 TCGA−CK−5914−01 TCGA−CK−4947−01 TCGA−CI−6622−01 TCGA−AZ−6605−01 TCGA−AY−5543−01 TCGA−AG−3742−01 TCGA−AF−6672−01 TCGA−AF−6136−01 TCGA−A6−5662−01 TCGA−A6−5659−01 TCGA−F4−6805−01 TCGA−EI−6508−01 TCGA−DM−A28F−01 TCGA−DM−A285−01 TCGA−DM−A1HA−01 TCGA−DM−A1D8−01 TCGA−DM−A1D7−01 TCGA−DM−A1D6−01 TCGA−DC−6682−01 TCGA−D5−6929−01 TCGA−D5−5541−01 TCGA−D5−5540−01 TCGA−CM−6677−01 TCGA−CM−6676−01 TCGA−CM−6675−01 TCGA−CM−6169−01 TCGA−CM−6165−01 TCGA−CM−4744−01 TCGA−CK−4948−01 TCGA−CI−6620−01 TCGA−CI−6619−01 TCGA−CA−6719−01 TCGA−AZ−5403−01 TCGA−AZ−4616−01 TCGA−AH−6544−01 TCGA−AG−A02N−01 TCGA−AG−A020−01 TCGA−AG−3885−01 TCGA−AG−3731−01 TCGA−AF−6655−01 TCGA−AF−4110−01 TCGA−AF−2691−01 TCGA−AF−2687−01 TCGA−AD−6965−01 TCGA−AD−6963−01 TCGA−AD−6548−01 TCGA−AA−A01K−01 TCGA−AA−3815−01 TCGA−AA−3712−01 TCGA−AA−3511−01 TCGA−A6−6654−01 TCGA−A6−6652−01 TCGA−A6−6649−01 TCGA−A6−5656−01 TCGA−A6−2676−01 TCGA−G4−6321−01 TCGA−F5−6812−01 TCGA−F5−6702−01 TCGA−F5−6464−01 TCGA−F4−6460−01 TCGA−DY−A1DC−01 TCGA−DT−5265−01 TCGA−DM−A28E−01 TCGA−DM−A1DA−01 TCGA−DC−6158−01 TCGA−DC−6157−01 TCGA−DC−6155−01 TCGA−D5−6924−01 TCGA−D5−6922−01 TCGA−D5−6920−01 TCGA−CM−6679−01 TCGA−CM−6163−01 TCGA−CM−5868−01 TCGA−CM−5341−01 TCGA−CA−6716−01 TCGA−CA−5797−01 TCGA−AZ−6607−01 TCGA−AZ−6600−01 TCGA−AZ−4323−01 TCGA−AH−6643−01 TCGA−AG−3732−01 TCGA−AG−3726−01 TCGA−AG−3594−01 TCGA−AG−3575−01 TCGA−AF−3913−01 TCGA−AF−2689−01 TCGA−AD−6899−01 TCGA−AD−6888−01 TCGA−AD−5900−01 TCGA−AA−A03J−01 TCGA−AA−3979−01 TCGA−AA−3860−01 TCGA−AA−3848−01 TCGA−AA−3558−01 TCGA−AA−3556−01 TCGA−A6−6782−01 TCGA−A6−2678−01 TCGA−G4−6310−01 TCGA−F4−6459−01 TCGA−DM−A1D0−01 TCGA−DC−5869−01 TCGA−D5−6930−01 TCGA−D5−6926−01 TCGA−CL−5918−01 TCGA−CI−6624−01 TCGA−AY−6196−01 TCGA−AY−4070−01 TCGA−AG−A032−01 TCGA−AG−A02X−01 TCGA−AG−A01W−01 TCGA−AG−A01L−01 TCGA−AG−A014−01 TCGA−AG−A00Y−01 TCGA−AG−A00C−01 TCGA−AG−4015−01 TCGA−AG−4008−01 TCGA−AG−4005−01 TCGA−AG−3999−01 TCGA−AG−3909−01 TCGA−AG−3902−01 TCGA−AG−3896−01 TCGA−AG−3611−01 TCGA−AG−3605−01 TCGA−AG−3602−01 TCGA−AG−3581−01 TCGA−AF−3400−01 TCGA−AA−A02W−01 TCGA−AA−A02F−01 TCGA−AA−A01Z−01 TCGA−AA−A01T−01 TCGA−AA−A01G−01 TCGA−AA−A01F−01 TCGA−AA−A00F−01 TCGA−AA−A00E−01 TCGA−AA−3976−01 TCGA−AA−3975−01 TCGA−AA−3972−01 TCGA−AA−3956−01 TCGA−AA−3949−01 TCGA−AA−3930−01 TCGA−AA−3866−01 TCGA−AA−3851−01 TCGA−AA−3844−01 TCGA−AA−3842−01 TCGA−AA−3814−01 TCGA−AA−3681−01 TCGA−AA−3679−01 TCGA−AA−3666−01 TCGA−AA−3561−01 TCGA−AA−3560−01 TCGA−AA−3552−01 TCGA−AA−3549−01 TCGA−AA−3542−01 TCGA−AA−3520−01 TCGA−A6−6651−01 TCGA−A6−6142−01 TCGA−A6−6138−01 TCGA−A6−2683−01 TCGA−F4−6704−01 TCGA−DY−A1DD−01 TCGA−CI−6621−01 TCGA−AY−4071−01 TCGA−AG−A036−01 TCGA−AG−A026−01 TCGA−AG−A01Y−01 TCGA−AG−A016−01 TCGA−AG−A011−01 TCGA−AG−4007−01 TCGA−AG−3898−01 TCGA−AG−3893−01 TCGA−AG−3890−01 TCGA−AG−3882−01 TCGA−AG−3612−01 TCGA−AG−3609−01 TCGA−AG−3608−01 TCGA−AG−3601−01 TCGA−AG−3598−01 TCGA−AG−3587−01 TCGA−AG−3578−01 TCGA−AA−A02J−01 TCGA−AA−A02H−01 TCGA−AA−A01S−01 TCGA−AA−A01D−01 TCGA−AA−A00W−01 TCGA−AA−A00L−01 TCGA−AA−A00D−01 TCGA−AA−3982−01 TCGA−AA−3980−01 TCGA−AA−3875−01 TCGA−AA−3869−01 TCGA−AA−3867−01 TCGA−AA−3858−01 TCGA−AA−3856−01 TCGA−AA−3693−01 TCGA−AA−3685−01 TCGA−AA−3667−01 TCGA−AA−3562−01 TCGA−AA−3553−01 TCGA−AA−3531−01 TCGA−AA−3526−01 TCGA−AA−3524−01 TCGA−AA−3519−01 TCGA−AA−3517−01 TCGA−A6−6137−01 TCGA−A6−3810−01 TCGA−A6−3807−01 TCGA−A6−2674−01 TCGA−A6−2670−01

Tetrachlorodibenzodioxin Inhibits The Reaction [[AHR Protein Binds To CDK4 Protein, CCND1 Protein] Results In Increased Phosphorylation Of RB1 Protein] FDR = 1.9e−12%, FDR nod = 2.3e−11% SMAD2/SMAD3:SMAD4 Heterotrimer Regulates Transcription FDR = 1.9e−12%, FDR nod = 2.5%

TCGA−G4−6309−01 TCGA−D5−6538−01 TCGA−AZ−6606−01 TCGA−AA−3866−01 TCGA−AY−6196−01 TCGA−AG−A02N−01 TCGA−AA−3977−01 TCGA−A6−3808−01 TCGA−G4−6588−01 TCGA−G4−6304−01 TCGA−D5−6927−01 TCGA−D5−6540−01 TCGA−AZ−6601−01 TCGA−AG−A002−01 TCGA−AA−A010−01 TCGA−AA−3715−01 TCGA−G4−6625−01 TCGA−G4−6586−01 TCGA−G4−6323−01 TCGA−G4−6321−01 TCGA−G4−6317−01 TCGA−G4−6315−01 TCGA−G4−6306−01 TCGA−G4−6299−01 TCGA−G4−6293−01 TCGA−F5−6812−01 TCGA−F5−6464−01 TCGA−F4−6806−01 TCGA−F4−6570−01 TCGA−EI−6510−01 TCGA−DY−A1H8−01 TCGA−DY−A0XA−01 TCGA−DM−A28H−01 TCGA−DM−A28G−01 TCGA−DM−A28F−01 TCGA−DM−A28C−01 TCGA−DM−A1D4−01 TCGA−DM−A0XD−01 TCGA−D5−7000−01 TCGA−D5−6932−01 TCGA−D5−6923−01 TCGA−D5−6898−01 TCGA−D5−6539−01 TCGA−D5−6535−01 TCGA−D5−6534−01 TCGA−D5−6533−01 TCGA−D5−6532−01 TCGA−D5−5539−01 TCGA−D5−5538−01 TCGA−CM−6678−01 TCGA−CM−6676−01 TCGA−CM−6674−01 TCGA−CM−6172−01 TCGA−CM−6171−01 TCGA−CM−6169−01 TCGA−CM−6165−01 TCGA−CM−6162−01 TCGA−CM−6161−01 TCGA−CM−5860−01 TCGA−CM−5349−01 TCGA−CM−5348−01 TCGA−CM−5344−01 TCGA−CM−5341−01 TCGA−CM−4752−01 TCGA−CM−4747−01 TCGA−CM−4743−01 TCGA−CK−4952−01 TCGA−CK−4950−01 TCGA−CI−6620−01 TCGA−CI−6619−01 TCGA−CA−6719−01 TCGA−CA−6717−01 TCGA−CA−5797−01 TCGA−AZ−6603−01 TCGA−AZ−6600−01 TCGA−AZ−6599−01 TCGA−AZ−6598−01 TCGA−AZ−4323−01 TCGA−AY−6197−01 TCGA−AU−6004−01 TCGA−AU−3779−01 TCGA−AH−6549−01 TCGA−AG−3881−01 TCGA−AG−3742−01 TCGA−AF−6672−01 TCGA−AF−4110−01 TCGA−AF−2693−01 TCGA−AD−6901−01 TCGA−AD−6895−01 TCGA−AD−6889−01 TCGA−AA−3968−01 TCGA−AA−3811−01 TCGA−AA−3713−01 TCGA−AA−3697−01 TCGA−AA−3662−01 TCGA−AA−3655−01 TCGA−AA−3510−01 TCGA−AA−3502−01 TCGA−AA−3496−01 TCGA−A6−6780−01 TCGA−A6−6652−01 TCGA−A6−6649−01 TCGA−A6−6142−01 TCGA−A6−6141−01 TCGA−A6−5666−01 TCGA−A6−5665−01 TCGA−A6−5662−01 TCGA−A6−5661−01 TCGA−A6−4105−01

TCGA−AF−2687−01 TCGA−AA−A00E−01 TCGA−AA−3852−01 TCGA−AA−3693−01 TCGA−AA−A01R−01 TCGA−AH−6644−01 TCGA−EI−6507−01 TCGA−AA−3538−01 TCGA−CM−6162−01 TCGA−G4−6315−01 TCGA−D5−6535−01 TCGA−AA−A02K−01 TCGA−AD−6889−01 TCGA−AA−3980−01 TCGA−AD−6963−01 TCGA−AA−3518−01 TCGA−F5−6702−01 TCGA−CM−6675−01 TCGA−CM−4746−01 TCGA−AD−6895−01 TCGA−CK−4947−01 TCGA−AA−A01P−01 TCGA−AD−5900−01 TCGA−DT−5265−01 TCGA−AA−3664−01 TCGA−AA−3525−01 TCGA−AA−A01Q−01 TCGA−AA−3715−01 TCGA−DM−A1D0−01 TCGA−AZ−5407−01 TCGA−AA−A022−01 TCGA−AG−3892−01 TCGA−AA−3947−01 TCGA−CM−6674−01 TCGA−AG−A026−01 TCGA−AA−3877−01 TCGA−A6−5661−01 TCGA−CA−6717−01 TCGA−D5−6931−01 TCGA−D5−6923−01 TCGA−CM−6679−01 TCGA−AZ−6608−01 TCGA−A6−6781−01 TCGA−CM−6678−01 TCGA−AA−A00J−01 TCGA−AA−3672−01 TCGA−A6−6653−01 TCGA−F4−6703−01 TCGA−AF−3913−01 TCGA−AA−3939−01 TCGA−AZ−4315−01 TCGA−AA−A010−01 TCGA−AA−3815−01 TCGA−AA−3710−01 TCGA−DY−A1DC−01 TCGA−DM−A1DA−01 TCGA−AG−A036−01 TCGA−AG−3896−01 TCGA−AA−3831−01 TCGA−DM−A28C−01 TCGA−D5−6932−01 TCGA−CI−6620−01 TCGA−AH−6549−01 TCGA−AH−6544−01 TCGA−AG−A00C−01 TCGA−AG−3878−01 TCGA−AF−4110−01 TCGA−AA−3875−01 TCGA−AA−3848−01 TCGA−G4−6588−01 TCGA−D5−6540−01 TCGA−CK−4948−01 TCGA−F4−6856−01 TCGA−CK−4952−01 TCGA−AA−3712−01 TCGA−AA−3492−01 TCGA−G4−6321−01 TCGA−DM−A1D6−01 TCGA−D5−6922−01 TCGA−D5−5537−01 TCGA−AY−5543−01 TCGA−AG−3882−01 TCGA−AG−3731−01 TCGA−A6−4105−01 TCGA−AG−A002−01 TCGA−AA−3510−01 TCGA−A6−6780−01 TCGA−AA−3663−01 TCGA−CM−6168−01 TCGA−AA−A00N−01 TCGA−AA−3977−01 TCGA−G5−6235−01 TCGA−CM−6169−01 TCGA−AG−A01W−01 TCGA−AG−3890−01 TCGA−AG−3608−01 TCGA−AA−A029−01 TCGA−AA−A024−01 TCGA−AA−A01V−01 TCGA−AA−3842−01 TCGA−AA−3696−01 TCGA−AA−3684−01 TCGA−AA−3864−01 TCGA−CA−6718−01 TCGA−AU−6004−01 TCGA−AA−3950−01 TCGA−A6−3809−01 TCGA−G4−6293−01 TCGA−DY−A0XA−01 TCGA−DM−A28K−01 TCGA−D5−6927−01 TCGA−CM−5349−01 TCGA−CA−6716−01 TCGA−AZ−6601−01 TCGA−AU−3779−01 TCGA−AA−3845−01 TCGA−AA−3555−01 TCGA−A6−2676−01 TCGA−G4−6626−01 TCGA−G4−6586−01 TCGA−G4−6310−01 TCGA−G4−6309−01 TCGA−F5−6812−01 TCGA−F5−6465−01 TCGA−F4−6855−01 TCGA−F4−6460−01 TCGA−DY−A1DD−01 TCGA−DC−5337−01 TCGA−D5−7000−01 TCGA−D5−6924−01 TCGA−D5−6920−01 TCGA−D5−6541−01 TCGA−D5−6536−01 TCGA−D5−6534−01 TCGA−D5−6533−01 TCGA−D5−6532−01 TCGA−CM−6171−01 TCGA−CM−5861−01 TCGA−CM−5348−01 TCGA−CM−4752−01 TCGA−CK−6746−01 TCGA−CK−5916−01 TCGA−CK−5915−01 TCGA−CK−4950−01 TCGA−AZ−6600−01 TCGA−AZ−6598−01 TCGA−AY−6386−01 TCGA−AY−6197−01 TCGA−AG−A011−01 TCGA−AA−3984−01 TCGA−AA−3662−01 TCGA−AA−3520−01 TCGA−A6−6654−01 TCGA−A6−6652−01 TCGA−A6−6138−01 TCGA−A6−6137−01 TCGA−A6−5660−01 TCGA−A6−5659−01 TCGA−A6−5656−01 TCGA−G4−6628−01 TCGA−G4−6625−01 TCGA−G4−6323−01 TCGA−G4−6317−01 TCGA−G4−6304−01 TCGA−G4−6303−01 TCGA−G4−6299−01 TCGA−F5−6464−01 TCGA−F4−6805−01 TCGA−F4−6570−01 TCGA−F4−6569−01 TCGA−EI−6508−01 TCGA−EI−6506−01 TCGA−DY−A1DG−01 TCGA−DY−A1DF−01 TCGA−DM−A28H−01 TCGA−DM−A285−01 TCGA−DM−A1DB−01 TCGA−DM−A1D9−01 TCGA−DM−A1D8−01 TCGA−DM−A1D4−01 TCGA−DM−A0XF−01 TCGA−DC−6681−01 TCGA−DC−6155−01 TCGA−D5−6930−01 TCGA−D5−6928−01 TCGA−D5−6898−01 TCGA−D5−5540−01 TCGA−D5−5539−01 TCGA−D5−5538−01 TCGA−CM−6680−01 TCGA−CM−6172−01 TCGA−CM−6170−01 TCGA−CM−6166−01 TCGA−CM−6165−01 TCGA−CM−6163−01 TCGA−CM−6161−01 TCGA−CM−5868−01 TCGA−CM−5860−01 TCGA−CM−5344−01 TCGA−CK−5914−01 TCGA−CA−6719−01 TCGA−CA−5796−01 TCGA−AZ−6607−01 TCGA−AZ−6605−01 TCGA−AZ−6603−01 TCGA−AZ−6599−01 TCGA−AZ−5403−01 TCGA−AZ−4681−01 TCGA−AZ−4616−01 TCGA−AY−6196−01 TCGA−AH−6547−01 TCGA−AG−A02X−01 TCGA−AG−A020−01 TCGA−AG−A016−01 TCGA−AG−A008−01 TCGA−AG−4005−01 TCGA−AG−3901−01 TCGA−AG−3887−01 TCGA−AG−3885−01 TCGA−AG−3732−01 TCGA−AF−6672−01 TCGA−AF−6136−01 TCGA−AF−2693−01 TCGA−AD−6964−01 TCGA−AD−6899−01 TCGA−AD−6888−01 TCGA−AA−A02O−01 TCGA−AA−A01D−01 TCGA−AA−A00K−01 TCGA−AA−3973−01 TCGA−AA−3968−01 TCGA−AA−3861−01 TCGA−AA−3821−01 TCGA−AA−3811−01 TCGA−AA−3713−01 TCGA−AA−3697−01 TCGA−AA−3692−01 TCGA−AA−3666−01 TCGA−AA−3660−01 TCGA−AA−3558−01 TCGA−AA−3530−01 TCGA−AA−3522−01 TCGA−AA−3496−01 TCGA−A6−6651−01 TCGA−A6−5664−01 TCGA−A6−2678−01

TGF Beta Super Family Signaling Pathway(canonical) ( TGF Beta BMP Diagram(MolecularVariation) ) FDR = 1.9e−12%, FDR nod = 0.31% TGF Beta Receptor Signaling Activates SMADs FDR = 1.9e−12%, FDR nod = 0.00021%

SMAD4

SMAD2

TGFBR1

SMAD3

FURIN

ZFYVE9

FKBP1A

NEDD8

TGFB1

UBE2M

CDK4 CCNT1

AHR E2F4

CCND1 SMAD7

wt wt TGFBR2

RB1

known HCG mut known HCG mut CBL

wt wt

unknown CG mut

SMAD4 CREBBP EP300 WT1 ACVR1B SMAD2 BMPR2 INHBA SMARCA4 SMAD3 BMP7 GDF3 GDF5 GDF6 ACVR2B BMP15 BMP5 BMPR1B TGFBR1 TGFBR2 ACVR2A ACVRL1 AMHR2 BMP10 BMP2 BMP6 ACVR1 BMP3 BMP4 BMPR1A GDF10 GDF11 GDF2 GDF7 GDF9 INHA INHBB INHBC INHBE MAML1 MAML2 MAML3 MSTN NODAL SMAD1 SMAD5 SMAD9 TGFB1 TGFB2 TGFB3 unknown CG mut

wt TFDP1

wt CCNT2


known HCG mut SMAD3

known HCG mut TGIF1

unknown CG mut unknown CG mut SMAD4


TP53

MTOR

ING1

IRF1

IFNB1

JUN

TP53 KRAS ATM PTEN PIK3CA CTNNB1 NRAS PIK3C2G PIK3C3 PIK3CG TP63 ATR CCNA1 MAPK13 PIK3C2B AKT1 AKT2 AKT3 CCNA2 CCNE1 CCNG1 CDK2 CDKN1A HRAS MAPK12 MAPK14 MYC PDPK1 PIK3C2A PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PIK3R5 PPP2CA PPP2CB RB1 RBL1 SIAH1 TP73

SMAD2

MEN1

SNW1

RBL1

SP1

CDK8

ATP1B4

CDK9

HDAC1

UBC

WWTR1

CCNC

E2F5

RNF111

SERPINE1

CCNK

JUNB

MYC

TFDP2

TGIF2

UBA52

TCGA−DM−A0X9−01 TCGA−D5−6538−01 TCGA−CA−5254−01 TCGA−AG−4008−01 TCGA−AA−A01P−01 TCGA−AG−A014−01 TCGA−AA−A02F−01 TCGA−CL−5918−01 TCGA−AA−A01Q−01 TCGA−D5−5541−01 TCGA−AG−3598−01 TCGA−AA−3664−01 TCGA−D5−6529−01 TCGA−AA−3553−01 TCGA−AA−3502−01 TCGA−AA−3975−01 TCGA−AA−3680−01 TCGA−CI−6621−01 TCGA−AG−A00Y−01 TCGA−DM−A28F−01 TCGA−AG−3883−01 TCGA−AA−3814−01 TCGA−CM−6677−01 TCGA−F5−6571−01 TCGA−D5−6932−01 TCGA−G4−6321−01 TCGA−F4−6856−01 TCGA−AA−A00L−01 TCGA−AA−3514−01 TCGA−F4−6703−01 TCGA−A6−4105−01 TCGA−DY−A1DC−01 TCGA−AA−3710−01 TCGA−AG−A036−01 TCGA−AG−3896−01 TCGA−CM−4746−01 TCGA−AG−4007−01 TCGA−AA−3712−01 TCGA−AA−3529−01 TCGA−AA−3524−01 TCGA−AG−3892−01 TCGA−AD−6901−01 TCGA−AA−3949−01 TCGA−F4−6704−01 TCGA−D5−6537−01 TCGA−AA−A00F−01 TCGA−A6−3808−01 TCGA−DM−A28C−01 TCGA−AZ−6606−01 TCGA−AA−3492−01 TCGA−A6−5661−01 TCGA−CK−6747−01 TCGA−AZ−5407−01 TCGA−AA−3525−01 TCGA−G4−6315−01 TCGA−DM−A1D6−01 TCGA−CM−6676−01 TCGA−A6−2670−01 TCGA−AA−3663−01 TCGA−AA−3977−01 TCGA−AA−A01V−01 TCGA−CM−6169−01 TCGA−AG−A01W−01 TCGA−AG−3890−01 TCGA−AG−3608−01 TCGA−AA−A024−01 TCGA−AA−3842−01 TCGA−AA−3696−01 TCGA−AA−3684−01 TCGA−CM−6674−01 TCGA−AA−A01R−01 TCGA−AA−3833−01 TCGA−CK−6751−01 TCGA−AA−3831−01 TCGA−AA−A03F−01 TCGA−DC−6158−01 TCGA−CA−6715−01 TCGA−AG−A01L−01 TCGA−AA−3994−01 TCGA−A6−3807−01 TCGA−CK−4952−01 TCGA−AD−6895−01 TCGA−F4−6806−01 TCGA−A6−2672−01 TCGA−CM−5864−01 TCGA−A6−5657−01 TCGA−G4−6306−01 TCGA−CM−6675−01 TCGA−CL−5917−01 TCGA−CK−4947−01 TCGA−AZ−4323−01 TCGA−AA−3930−01 TCGA−AA−3544−01 TCGA−A6−5662−01 TCGA−AA−A00N−01 TCGA−AD−6889−01 TCGA−A6−6653−01 TCGA−AA−A00J−01 TCGA−CM−6162−01 TCGA−A6−6781−01 TCGA−A6−6780−01 TCGA−D5−6931−01 TCGA−D5−6539−01 TCGA−CK−5913−01 TCGA−G5−6235−01 TCGA−F5−6813−01 TCGA−DM−A1D0−01 TCGA−AA−A00R−01 TCGA−AA−3554−01 TCGA−A6−6141−01 TCGA−G5−6641−01 TCGA−DC−6682−01 TCGA−CI−6619−01 TCGA−AF−2687−01 TCGA−AA−A01G−01 TCGA−AA−3655−01 TCGA−AA−3527−01 TCGA−AG−A002−01 TCGA−AA−A010−01 TCGA−CA−6717−01 TCGA−AA−3510−01 TCGA−G4−6588−01 TCGA−CM−4743−01 TCGA−AZ−4315−01 TCGA−AA−3815−01 TCGA−AA−3672−01 TCGA−EI−6507−01 TCGA−DM−A1DA−01 TCGA−AG−A02N−01 TCGA−A6−5665−01 TCGA−AD−5900−01 TCGA−AA−A029−01 TCGA−AA−3715−01 TCGA−CM−6168−01 TCGA−AA−A022−01 TCGA−AA−3966−01 TCGA−AA−3877−01 TCGA−AA−3516−01 TCGA−D5−6540−01 TCGA−CK−4948−01 TCGA−AA−3518−01 TCGA−F4−6808−01 TCGA−EI−6510−01 TCGA−DM−A1HA−01 TCGA−D5−6923−01 TCGA−D5−6535−01 TCGA−CI−6620−01 TCGA−AH−6643−01 TCGA−AA−A00E−01 TCGA−AA−3947−01 TCGA−G4−6307−01 TCGA−DM−A1D7−01 TCGA−D5−5537−01 TCGA−CM−6164−01 TCGA−AY−5543−01 TCGA−AH−6549−01 TCGA−AH−6544−01 TCGA−AG−3731−01 TCGA−AD−6963−01 TCGA−AA−3818−01 TCGA−G4−6628−01 TCGA−AZ−6598−01 TCGA−D5−6928−01 TCGA−AZ−6601−01 TCGA−AD−6964−01 TCGA−AA−3984−01 TCGA−AA−3864−01 TCGA−G4−6586−01 TCGA−AY−6197−01 TCGA−AU−6004−01 TCGA−AA−3662−01 TCGA−G4−6304−01 TCGA−CM−6171−01 TCGA−CK−6746−01 TCGA−CA−6718−01 TCGA−F4−6460−01 TCGA−D5−6927−01 TCGA−CM−5861−01 TCGA−CM−5344−01 TCGA−AZ−6600−01 TCGA−AA−3950−01 TCGA−AA−3713−01 TCGA−AA−3555−01 TCGA−AA−3520−01 TCGA−A6−3809−01 TCGA−A6−2676−01 TCGA−G4−6625−01 TCGA−G4−6317−01 TCGA−G4−6310−01 TCGA−G4−6309−01 TCGA−G4−6303−01 TCGA−DY−A1DG−01 TCGA−DM−A28K−01 TCGA−DM−A1D8−01 TCGA−D5−6930−01 TCGA−D5−6536−01 TCGA−D5−5540−01 TCGA−D5−5538−01 TCGA−CM−6161−01 TCGA−CM−5348−01 TCGA−CM−4752−01 TCGA−CK−5916−01 TCGA−AY−6386−01 TCGA−AY−6196−01 TCGA−AU−3779−01 TCGA−AA−3968−01 TCGA−AA−3845−01 TCGA−AA−3666−01 TCGA−G4−6323−01 TCGA−G4−6293−01 TCGA−F5−6812−01 TCGA−F5−6465−01 TCGA−F4−6570−01 TCGA−F4−6569−01 TCGA−DY−A1DF−01 TCGA−DY−A0XA−01 TCGA−DM−A28H−01 TCGA−DM−A1D9−01 TCGA−DM−A1D4−01 TCGA−DC−6681−01 TCGA−D5−6924−01 TCGA−D5−6534−01 TCGA−D5−6533−01 TCGA−D5−6532−01 TCGA−D5−5539−01 TCGA−CM−6680−01 TCGA−CM−6166−01 TCGA−CM−5868−01 TCGA−CM−5349−01 TCGA−CK−5915−01 TCGA−CK−5914−01 TCGA−CK−4950−01 TCGA−CA−6719−01 TCGA−CA−5796−01 TCGA−AZ−6599−01 TCGA−AG−A011−01 TCGA−AG−3732−01 TCGA−AF−6672−01 TCGA−AF−6136−01 TCGA−AA−3973−01 TCGA−AA−3821−01 TCGA−AA−3811−01 TCGA−AA−3660−01 TCGA−AA−3558−01 TCGA−A6−6652−01 TCGA−A6−6138−01 TCGA−A6−5664−01 TCGA−A6−5660−01 TCGA−A6−5659−01 TCGA−G4−6626−01 TCGA−G4−6299−01 TCGA−F5−6464−01 TCGA−F4−6855−01 TCGA−F4−6805−01 TCGA−EI−6508−01 TCGA−EI−6506−01 TCGA−DY−A1DD−01 TCGA−DM−A285−01 TCGA−DM−A1DB−01 TCGA−DM−A0XF−01 TCGA−DC−6155−01 TCGA−DC−5337−01 TCGA−D5−7000−01 TCGA−D5−6920−01 TCGA−D5−6898−01 TCGA−D5−6541−01 TCGA−CM−6172−01 TCGA−CM−6170−01 TCGA−CM−6165−01 TCGA−CM−6163−01 TCGA−CM−5860−01 TCGA−CA−6716−01 TCGA−AZ−6607−01 TCGA−AZ−6605−01 TCGA−AZ−6603−01 TCGA−AZ−5403−01 TCGA−AZ−4681−01 TCGA−AZ−4616−01 TCGA−AH−6547−01 TCGA−AG−A02X−01 TCGA−AG−A020−01 TCGA−AG−A016−01 TCGA−AG−A008−01 TCGA−AG−4005−01 TCGA−AG−3901−01 TCGA−AG−3887−01 TCGA−AG−3885−01 TCGA−AF−2693−01 TCGA−AD−6899−01 TCGA−AD−6888−01 TCGA−AA−A02O−01 TCGA−AA−A01D−01 TCGA−AA−A00K−01 TCGA−AA−3861−01 TCGA−AA−3697−01 TCGA−AA−3692−01 TCGA−AA−3530−01 TCGA−AA−3522−01 TCGA−AA−3496−01 TCGA−A6−6654−01 TCGA−A6−6651−01 TCGA−A6−6137−01 TCGA−A6−5656−01 TCGA−A6−2678−01

TCGA−CK−5913−01 TCGA−CL−5917−01 TCGA−AG−3605−01 TCGA−AA−3855−01 TCGA−AD−6889−01 TCGA−EI−6507−01 TCGA−AG−3883−01 TCGA−A6−5665−01 TCGA−AA−3710−01 TCGA−AA−3815−01 TCGA−DM−A1DA−01 TCGA−CK−4948−01 TCGA−AG−A036−01 TCGA−AG−3896−01 TCGA−AA−3831−01 TCGA−CA−6717−01 TCGA−AG−3892−01 TCGA−F4−6806−01 TCGA−D5−5541−01 TCGA−CK−6751−01 TCGA−AG−A02N−01 TCGA−AG−3598−01 TCGA−AA−A00R−01 TCGA−AA−A00J−01 TCGA−A6−6653−01 TCGA−AA−3492−01 TCGA−G4−6588−01 TCGA−DY−A1DC−01 TCGA−CK−4952−01 TCGA−D5−6931−01 TCGA−CM−6674−01 TCGA−CL−5918−01 TCGA−AA−A03F−01 TCGA−AA−A01R−01 TCGA−AA−A01Q−01 TCGA−AA−3514−01 TCGA−A6−6141−01 TCGA−A6−5661−01 TCGA−A6−3808−01 TCGA−AA−A029−01 TCGA−AA−A00N−01 TCGA−AA−3977−01 TCGA−AA−3663−01 TCGA−A6−6780−01 TCGA−G5−6235−01 TCGA−CM−6169−01 TCGA−CM−6168−01 TCGA−AG−A01W−01 TCGA−AG−3890−01 TCGA−AG−3608−01 TCGA−AA−A024−01 TCGA−AA−A01V−01 TCGA−AA−3842−01 TCGA−AA−3696−01 TCGA−AA−3684−01 TCGA−AA−A010−01 TCGA−AG−A002−01 TCGA−AA−3510−01 TCGA−AZ−4315−01 TCGA−CM−4743−01 TCGA−AZ−6608−01 TCGA−AY−5543−01 TCGA−EF−5830−01 TCGA−DM−A28E−01 TCGA−D5−6923−01 TCGA−CM−6676−01 TCGA−CM−6164−01 TCGA−CM−5862−01 TCGA−CK−4947−01 TCGA−AZ−5407−01 TCGA−AG−3742−01 TCGA−AF−2687−01 TCGA−AD−5900−01 TCGA−AA−3518−01 TCGA−AA−3511−01 TCGA−A6−5662−01 TCGA−A6−5657−01 TCGA−G4−6310−01 TCGA−AA−3864−01 TCGA−G4−6628−01 TCGA−DY−A0XA−01 TCGA−AZ−6600−01 TCGA−AD−6964−01 TCGA−AA−3984−01 TCGA−AA−3968−01 TCGA−AA−3662−01 TCGA−G4−6586−01 TCGA−G4−6323−01 TCGA−G4−6309−01 TCGA−G4−6303−01 TCGA−F5−6465−01 TCGA−F4−6460−01 TCGA−DY−A1DF−01 TCGA−DM−A28K−01 TCGA−DM−A1DB−01 TCGA−D5−6927−01 TCGA−D5−6533−01 TCGA−D5−5540−01 TCGA−CM−6172−01 TCGA−CM−6171−01 TCGA−CM−6161−01 TCGA−CM−5348−01 TCGA−CM−4752−01 TCGA−CA−6719−01 TCGA−CA−6718−01 TCGA−AZ−6603−01 TCGA−AZ−6601−01 TCGA−AZ−6599−01 TCGA−AZ−6598−01 TCGA−AY−6386−01 TCGA−AY−6197−01 TCGA−AG−A011−01 TCGA−AA−3660−01 TCGA−AA−3555−01 TCGA−AA−3520−01 TCGA−A6−6138−01 TCGA−A6−5660−01 TCGA−A6−3809−01 TCGA−G4−6626−01 TCGA−G4−6625−01 TCGA−G4−6317−01 TCGA−G4−6304−01 TCGA−G4−6299−01 TCGA−G4−6293−01 TCGA−F5−6812−01 TCGA−F5−6464−01 TCGA−F4−6855−01 TCGA−F4−6805−01 TCGA−F4−6570−01 TCGA−F4−6569−01 TCGA−EI−6508−01 TCGA−EI−6506−01 TCGA−DY−A1DG−01 TCGA−DY−A1DD−01 TCGA−DM−A28H−01 TCGA−DM−A285−01 TCGA−DM−A1D9−01 TCGA−DM−A1D8−01 TCGA−DM−A1D4−01 TCGA−DM−A0XF−01 TCGA−DC−6681−01 TCGA−DC−6155−01 TCGA−DC−5337−01 TCGA−D5−7000−01 TCGA−D5−6930−01 TCGA−D5−6928−01 TCGA−D5−6924−01 TCGA−D5−6920−01 TCGA−D5−6898−01 TCGA−D5−6541−01 TCGA−D5−6536−01 TCGA−D5−6534−01 TCGA−D5−6532−01 TCGA−D5−5539−01 TCGA−D5−5538−01 TCGA−CM−6680−01 TCGA−CM−6170−01 TCGA−CM−6166−01 TCGA−CM−6165−01 TCGA−CM−6163−01 TCGA−CM−5868−01 TCGA−CM−5861−01 TCGA−CM−5860−01 TCGA−CM−5349−01 TCGA−CM−5344−01 TCGA−CK−6746−01 TCGA−CK−5916−01 TCGA−CK−5915−01 TCGA−CK−5914−01 TCGA−CK−4950−01 TCGA−CA−6716−01 TCGA−CA−5796−01 TCGA−AZ−6607−01 TCGA−AZ−6605−01 TCGA−AZ−5403−01 TCGA−AZ−4681−01 TCGA−AZ−4616−01 TCGA−AY−6196−01 TCGA−AU−6004−01 TCGA−AU−3779−01 TCGA−AH−6547−01 TCGA−AG−A02X−01 TCGA−AG−A020−01 TCGA−AG−A016−01 TCGA−AG−A008−01 TCGA−AG−4005−01 TCGA−AG−3901−01 TCGA−AG−3887−01 TCGA−AG−3885−01 TCGA−AG−3732−01 TCGA−AF−6672−01 TCGA−AF−6136−01 TCGA−AF−2693−01 TCGA−AD−6899−01 TCGA−AD−6888−01 TCGA−AA−A02O−01 TCGA−AA−A01D−01 TCGA−AA−A00K−01 TCGA−AA−3973−01 TCGA−AA−3950−01 TCGA−AA−3861−01 TCGA−AA−3845−01 TCGA−AA−3821−01 TCGA−AA−3811−01 TCGA−AA−3713−01 TCGA−AA−3697−01 TCGA−AA−3692−01 TCGA−AA−3666−01 TCGA−AA−3558−01 TCGA−AA−3530−01 TCGA−AA−3522−01 TCGA−AA−3496−01 TCGA−A6−6654−01 TCGA−A6−6652−01 TCGA−A6−6651−01 TCGA−A6−6137−01 TCGA−A6−5664−01 TCGA−A6−5659−01 TCGA−A6−5656−01 TCGA−A6−2678−01 TCGA−A6−2676−01

TP53 Regulates Transcription Of Death Receptors And Ligands FDR = 1.9e−12%, FDR nod = 3.6% TP53 Regulates Transcription Of Caspase Activators And Caspases FDR = 1.9e−12%, FDR nod = 1.1%

CASP2

TP53BP2

NLRC4

FAS

CASP1

TNFRSF10C

CASP10

TNFRSF10A

CASP6

TP73

CRADD

TMEM219

PIDD1

TNFRSF10B

TP73

TNFRSF10D

TP53

EP300

CCNB1

CDK1

PCNA

TFDP1

AURKA

CARM1

CDC25C

E2F4

RBL1

PRMT1

SFN

TFDP2

ZNF385A

BRCA1

CCNE1

CDK2

CSTF1

FANCC

FANCE

TOPBP1

UBE2L3

BACH1

EWSR1

FANCA

FANCF

FANCG

FANCL

MRE11A

NBN

RBBP8

UBE2D3

XRCC5

XRCC6

wt PCNA wt


known HCG mut ATR known HCG mut


unknown CG mut TP53 unknown CG mut

ATM

PRKDC

FANCD2

RAD50

BARD1

BRCA2 ATR CLSPN FANCD2 CEP164 FBXW11 PLK1 CDC6 NBN PPP2R2B TOPBP1 CCNA2 PPP2R1A RPA1 SMARCAL1 CHEK1 BTRC CDC25C TIMELESS YWHAB ATRIP HUS1 MCM7 MDM2 RAD17 RAD9A RFC5 CDC25A CDK2 MCM2 PPP2CA RAD1 RFC2 RFC4 RPA2 TIPIN YWHAZ

TCGA−AA−3831−01 TCGA−F4−6856−01 TCGA−AA−A02F−01 TCGA−AG−A032−01 TCGA−CK−5915−01 TCGA−AA−3870−01 TCGA−AA−3667−01 TCGA−A6−6654−01 TCGA−AG−3893−01 TCGA−AG−A02G−01 TCGA−G4−6309−01 TCGA−AA−3845−01 TCGA−AA−A02K−01 TCGA−AA−A017−01 TCGA−AG−3609−01 TCGA−AA−3526−01 TCGA−AF−6136−01 TCGA−DM−A1HA−01 TCGA−F5−6811−01 TCGA−AA−3514−01 TCGA−CK−6746−01 TCGA−D5−6926−01 TCGA−AG−A02N−01 TCGA−A6−3808−01 TCGA−DT−5265−01 TCGA−CM−4746−01 TCGA−AG−3612−01 TCGA−G4−6626−01 TCGA−AZ−6606−01 TCGA−A6−6648−01 TCGA−AA−3663−01 TCGA−CM−6168−01 TCGA−DM−A0X9−01 TCGA−AG−A020−01 TCGA−AA−3833−01 TCGA−AA−3518−01 TCGA−D5−6930−01 TCGA−AD−6964−01 TCGA−A6−3810−01 TCGA−AA−3516−01 TCGA−AA−A01V−01 TCGA−AA−A01T−01 TCGA−AG−3885−01 TCGA−AG−A011−01 TCGA−AG−3731−01 TCGA−AD−5900−01 TCGA−CA−6718−01 TCGA−AA−3710−01 TCGA−G4−6303−01 TCGA−F4−6854−01 TCGA−AG−A01Y−01 TCGA−AA−3939−01 TCGA−AA−3855−01 TCGA−CK−5916−01 TCGA−DM−A1D6−01 TCGA−AA−A00E−01 TCGA−A6−6782−01 TCGA−D5−5537−01 TCGA−CM−5864−01 TCGA−CK−4948−01 TCGA−AA−3977−01 TCGA−AA−3492−01 TCGA−AA−A022−01 TCGA−AA−A01Q−01 TCGA−AA−3949−01 TCGA−F4−6569−01 TCGA−CI−6621−01 TCGA−AA−3982−01 TCGA−AA−3858−01 TCGA−AA−3525−01 TCGA−EI−6507−01 TCGA−A6−6653−01 TCGA−DC−6682−01 TCGA−CA−5796−01 TCGA−AA−3877−01 TCGA−G5−6641−01 TCGA−D5−6931−01 TCGA−D5−5540−01 TCGA−AG−3732−01 TCGA−AF−2687−01 TCGA−AA−A01G−01 TCGA−AA−A00R−01 TCGA−AA−A00J−01 TCGA−AA−3554−01 TCGA−AA−3527−01 TCGA−AA−3864−01 TCGA−D5−6928−01 TCGA−AA−3947−01 TCGA−AA−3672−01 TCGA−AA−A01R−01 TCGA−AA−3660−01 TCGA−DM−A0XF−01 TCGA−CM−5868−01 TCGA−CA−6716−01 TCGA−AY−6196−01 TCGA−AA−3666−01 TCGA−A6−5659−01 TCGA−G4−6310−01 TCGA−F5−6465−01 TCGA−DM−A282−01 TCGA−DM−A1D9−01 TCGA−D5−6922−01 TCGA−CM−6675−01 TCGA−AA−3952−01 TCGA−AA−3510−01 TCGA−G4−6588−01 TCGA−AD−6889−01 TCGA−AA−3715−01 TCGA−CM−6162−01 TCGA−CI−6619−01 TCGA−AD−6895−01 TCGA−A6−6780−01 TCGA−A6−6141−01 TCGA−D5−6923−01 TCGA−CM−5344−01 TCGA−AZ−4323−01 TCGA−G4−6315−01 TCGA−G4−6304−01 TCGA−DY−A0XA−01 TCGA−DM−A28F−01 TCGA−DM−A1D4−01 TCGA−D5−7000−01 TCGA−D5−6534−01 TCGA−D5−6533−01 TCGA−CM−5860−01 TCGA−CM−4752−01 TCGA−CK−4950−01 TCGA−CA−5797−01 TCGA−AA−3811−01 TCGA−G4−6299−01 TCGA−F5−6812−01 TCGA−F5−6464−01 TCGA−F4−6806−01 TCGA−DY−A1H8−01 TCGA−DM−A28G−01 TCGA−DM−A28C−01 TCGA−D5−6927−01 TCGA−D5−6898−01 TCGA−D5−6532−01 TCGA−D5−5538−01 TCGA−CM−6678−01 TCGA−CM−6676−01 TCGA−CM−6169−01 TCGA−CM−6165−01 TCGA−CM−6161−01 TCGA−CM−5341−01 TCGA−CM−4747−01 TCGA−CI−6620−01 TCGA−AZ−6603−01 TCGA−AH−6549−01 TCGA−AG−3881−01 TCGA−AG−3742−01 TCGA−AF−6672−01 TCGA−AF−4110−01 TCGA−AD−6901−01 TCGA−AA−3968−01 TCGA−AA−3502−01 TCGA−A6−6649−01 TCGA−A6−4105−01 TCGA−AG−A002−01 TCGA−AA−A010−01 TCGA−CA−6717−01 TCGA−AA−3984−01 TCGA−F4−6570−01 TCGA−AZ−6598−01 TCGA−AZ−4315−01 TCGA−AG−3892−01 TCGA−AA−A00N−01 TCGA−CM−6171−01 TCGA−AZ−6601−01 TCGA−AY−6386−01 TCGA−A6−6781−01 TCGA−A6−5665−01 TCGA−G4−6586−01 TCGA−CM−6172−01 TCGA−CM−5861−01 TCGA−CM−4743−01 TCGA−AY−6197−01 TCGA−AA−3662−01 TCGA−EI−6510−01 TCGA−D5−6539−01 TCGA−D5−5539−01 TCGA−CM−5349−01 TCGA−CK−5913−01 TCGA−AZ−6599−01 TCGA−AU−6004−01 TCGA−AA−3655−01 TCGA−AA−3555−01 TCGA−AA−3496−01 TCGA−A6−5666−01 TCGA−G5−6235−01 TCGA−G4−6628−01 TCGA−G4−6323−01 TCGA−G4−6317−01 TCGA−G4−6306−01 TCGA−F5−6813−01 TCGA−F4−6460−01 TCGA−F4−6459−01 TCGA−DM−A1DA−01 TCGA−CM−5348−01 TCGA−CL−5918−01 TCGA−CK−4952−01 TCGA−AZ−6607−01 TCGA−AU−3779−01 TCGA−AA−3713−01 TCGA−A6−5661−01 TCGA−G4−6625−01 TCGA−G4−6321−01 TCGA−G4−6293−01 TCGA−F4−6807−01 TCGA−EI−6506−01 TCGA−DM−A28H−01 TCGA−DM−A1DB−01 TCGA−DM−A1D7−01 TCGA−DM−A1D0−01 TCGA−DM−A0XD−01 TCGA−D5−6932−01 TCGA−D5−6929−01 TCGA−D5−6540−01 TCGA−D5−6537−01 TCGA−D5−6535−01 TCGA−CM−6674−01 TCGA−CM−5862−01 TCGA−CA−6719−01 TCGA−CA−6715−01 TCGA−AZ−6600−01 TCGA−AZ−5407−01 TCGA−AF−2693−01 TCGA−AA−3950−01 TCGA−AA−3697−01 TCGA−A6−6652−01 TCGA−A6−6142−01 TCGA−A6−5662−01 TCGA−A6−5657−01 TCGA−A6−3809−01 TCGA−G4−6307−01 TCGA−F4−6704−01 TCGA−EF−5830−01 TCGA−DY−A1DG−01 TCGA−DM−A28K−01 TCGA−DM−A285−01 TCGA−DC−6683−01 TCGA−D5−6536−01 TCGA−CM−6167−01 TCGA−CM−6164−01 TCGA−CM−6163−01 TCGA−CL−5917−01 TCGA−CK−6751−01 TCGA−CK−5912−01 TCGA−CI−6624−01 TCGA−CI−6622−01 TCGA−CA−5255−01 TCGA−AZ−6605−01 TCGA−AZ−4616−01 TCGA−AY−5543−01 TCGA−AH−6643−01 TCGA−AG−A015−01 TCGA−AF−6655−01 TCGA−AD−6965−01 TCGA−AD−6890−01 TCGA−AA−3956−01 TCGA−A6−2671−01

TCGA−D5−6534−01 TCGA−F4−6855−01 TCGA−AA−A01R−01 TCGA−AA−3678−01 TCGA−AA−A00A−01 TCGA−CM−6674−01 TCGA−AA−3950−01 TCGA−CM−6678−01 TCGA−F5−6465−01 TCGA−AA−3688−01 TCGA−CK−6746−01 TCGA−AZ−6603−01 TCGA−A6−5661−01 TCGA−A6−5657−01 TCGA−D5−6928−01 TCGA−AA−3510−01 TCGA−F4−6570−01 TCGA−AA−3966−01 TCGA−G4−6588−01 TCGA−AZ−4315−01 TCGA−CM−5861−01 TCGA−AD−6895−01 TCGA−AA−A022−01 TCGA−AA−A01Q−01 TCGA−A6−3809−01 TCGA−AG−A002−01 TCGA−AA−3864−01 TCGA−AY−6386−01 TCGA−AA−A00N−01 TCGA−AA−A00J−01 TCGA−AD−6889−01 TCGA−AA−3715−01 TCGA−AA−3554−01 TCGA−A6−6781−01 TCGA−A6−6780−01 TCGA−A6−6141−01 TCGA−G5−6641−01 TCGA−CK−5913−01 TCGA−CA−5796−01 TCGA−AA−A00R−01 TCGA−AA−3877−01 TCGA−AA−3555−01 TCGA−AA−3527−01 TCGA−A6−6653−01 TCGA−CA−6717−01 TCGA−AA−A010−01 TCGA−A6−5665−01 TCGA−D5−6931−01 TCGA−AA−3663−01 TCGA−G4−6293−01 TCGA−EI−6507−01 TCGA−DM−A1D0−01 TCGA−CM−4743−01 TCGA−AZ−6608−01 TCGA−AZ−6605−01 TCGA−AZ−6598−01 TCGA−AU−6004−01 TCGA−AF−2687−01 TCGA−AD−5900−01 TCGA−AA−3977−01 TCGA−G5−6235−01 TCGA−G4−6628−01 TCGA−G4−6626−01 TCGA−G4−6323−01 TCGA−F5−6813−01 TCGA−EI−6510−01 TCGA−DY−A1DF−01 TCGA−DY−A0XA−01 TCGA−DM−A28H−01 TCGA−DM−A1DA−01 TCGA−DC−6682−01 TCGA−DC−5337−01 TCGA−D5−6923−01 TCGA−D5−6541−01 TCGA−D5−6539−01 TCGA−D5−5540−01 TCGA−D5−5538−01 TCGA−CM−6679−01 TCGA−CM−6677−01 TCGA−CM−6171−01 TCGA−CM−6169−01 TCGA−CM−6162−01 TCGA−CM−5868−01 TCGA−CM−5864−01 TCGA−CM−4752−01 TCGA−CM−4746−01 TCGA−CK−4952−01 TCGA−CI−6619−01 TCGA−CA−6718−01 TCGA−AZ−5407−01 TCGA−AY−6197−01 TCGA−AG−A036−01 TCGA−AG−3999−01 TCGA−AG−3742−01 TCGA−AG−3732−01 TCGA−AF−4110−01 TCGA−AA−A01K−01 TCGA−AA−A01G−01 TCGA−AA−3949−01 TCGA−AA−3811−01 TCGA−AA−3679−01 TCGA−AA−3662−01 TCGA−AA−3655−01 TCGA−AA−3558−01 TCGA−A6−6654−01 TCGA−A6−5659−01 TCGA−A6−5656−01 TCGA−A6−2676−01 TCGA−G4−6625−01 TCGA−G4−6586−01 TCGA−G4−6321−01 TCGA−G4−6317−01 TCGA−G4−6315−01 TCGA−G4−6310−01 TCGA−G4−6307−01 TCGA−G4−6306−01 TCGA−G4−6304−01 TCGA−G4−6303−01 TCGA−G4−6299−01 TCGA−F5−6812−01 TCGA−F5−6702−01 TCGA−F5−6571−01 TCGA−F5−6464−01 TCGA−F4−6856−01 TCGA−F4−6854−01 TCGA−F4−6808−01 TCGA−F4−6807−01 TCGA−F4−6806−01 TCGA−F4−6805−01 TCGA−F4−6704−01 TCGA−F4−6703−01 TCGA−F4−6460−01 TCGA−F4−6459−01 TCGA−EI−6508−01 TCGA−EI−6506−01 TCGA−EF−5830−01 TCGA−DY−A1DG−01 TCGA−DY−A1DD−01 TCGA−DY−A1DC−01 TCGA−DT−5265−01 TCGA−DM−A28K−01 TCGA−DM−A28F−01 TCGA−DM−A28E−01 TCGA−DM−A285−01 TCGA−DM−A1HA−01 TCGA−DM−A1DB−01 TCGA−DM−A1D9−01 TCGA−DM−A1D8−01 TCGA−DM−A1D7−01 TCGA−DM−A1D6−01 TCGA−DM−A1D4−01 TCGA−DM−A0XF−01 TCGA−DM−A0XD−01 TCGA−DC−6683−01 TCGA−DC−6158−01 TCGA−DC−6157−01 TCGA−DC−6155−01 TCGA−DC−5869−01 TCGA−D5−6932−01 TCGA−D5−6930−01 TCGA−D5−6929−01 TCGA−D5−6927−01 TCGA−D5−6926−01 TCGA−D5−6924−01 TCGA−D5−6922−01 TCGA−D5−6920−01 TCGA−D5−6898−01 TCGA−D5−6540−01 TCGA−D5−6538−01 TCGA−D5−6535−01 TCGA−D5−6533−01 TCGA−D5−6532−01 TCGA−D5−5541−01 TCGA−CM−6676−01 TCGA−CM−6675−01 TCGA−CM−6172−01 TCGA−CM−6168−01 TCGA−CM−6166−01 TCGA−CM−6165−01 TCGA−CM−6164−01 TCGA−CM−6163−01 TCGA−CM−6161−01 TCGA−CM−5862−01 TCGA−CM−5860−01 TCGA−CM−5349−01 TCGA−CM−5348−01 TCGA−CM−5341−01 TCGA−CM−4744−01 TCGA−CL−5918−01 TCGA−CL−5917−01 TCGA−CK−5916−01 TCGA−CK−5914−01 TCGA−CK−4950−01 TCGA−CK−4948−01 TCGA−CK−4947−01 TCGA−CI−6624−01 TCGA−CI−6622−01 TCGA−CI−6621−01 TCGA−CI−6620−01 TCGA−CA−6719−01 TCGA−CA−6716−01 TCGA−CA−5797−01 TCGA−AZ−6607−01 TCGA−AZ−6601−01 TCGA−AZ−6600−01 TCGA−AZ−6599−01 TCGA−AZ−5403−01 TCGA−AZ−4616−01 TCGA−AZ−4323−01 TCGA−AY−6196−01 TCGA−AY−5543−01 TCGA−AY−4071−01 TCGA−AY−4070−01 TCGA−AU−3779−01 TCGA−AH−6643−01 TCGA−AH−6544−01 TCGA−AG−A032−01 TCGA−AG−A02X−01 TCGA−AG−A02N−01 TCGA−AG−A026−01 TCGA−AG−A020−01 TCGA−AG−A01Y−01 TCGA−AG−A01W−01 TCGA−AG−A01L−01 TCGA−AG−A016−01 TCGA−AG−A014−01 TCGA−AG−A011−01 TCGA−AG−A00Y−01 TCGA−AG−A00C−01 TCGA−AG−4015−01 TCGA−AG−4008−01 TCGA−AG−4007−01 TCGA−AG−4005−01 TCGA−AG−3909−01 TCGA−AG−3902−01 TCGA−AG−3898−01 TCGA−AG−3896−01 TCGA−AG−3893−01 TCGA−AG−3890−01 TCGA−AG−3885−01 TCGA−AG−3882−01 TCGA−AG−3731−01 TCGA−AG−3726−01 TCGA−AG−3612−01 TCGA−AG−3611−01 TCGA−AG−3609−01 TCGA−AG−3608−01 TCGA−AG−3605−01 TCGA−AG−3602−01 TCGA−AG−3601−01 TCGA−AG−3598−01 TCGA−AG−3594−01 TCGA−AG−3587−01 TCGA−AG−3581−01 TCGA−AG−3578−01 TCGA−AG−3575−01 TCGA−AF−6672−01 TCGA−AF−6655−01 TCGA−AF−6136−01 TCGA−AF−3913−01 TCGA−AF−3400−01 TCGA−AF−2693−01 TCGA−AF−2691−01 TCGA−AF−2689−01 TCGA−AD−6965−01 TCGA−AD−6963−01 TCGA−AD−6901−01 TCGA−AD−6899−01 TCGA−AD−6888−01 TCGA−AD−6548−01 TCGA−AA−A03J−01 TCGA−AA−A02W−01 TCGA−AA−A02J−01 TCGA−AA−A02H−01 TCGA−AA−A02F−01 TCGA−AA−A01Z−01 TCGA−AA−A01T−01 TCGA−AA−A01S−01 TCGA−AA−A01F−01 TCGA−AA−A01D−01 TCGA−AA−A00W−01 TCGA−AA−A00L−01 TCGA−AA−A00F−01 TCGA−AA−A00E−01 TCGA−AA−A00D−01 TCGA−AA−3982−01 TCGA−AA−3980−01 TCGA−AA−3979−01 TCGA−AA−3976−01 TCGA−AA−3975−01 TCGA−AA−3972−01 TCGA−AA−3956−01 TCGA−AA−3930−01 TCGA−AA−3875−01 TCGA−AA−3869−01 TCGA−AA−3867−01 TCGA−AA−3866−01 TCGA−AA−3860−01 TCGA−AA−3858−01 TCGA−AA−3856−01 TCGA−AA−3851−01 TCGA−AA−3848−01 TCGA−AA−3844−01 TCGA−AA−3842−01 TCGA−AA−3815−01 TCGA−AA−3814−01 TCGA−AA−3713−01 TCGA−AA−3712−01 TCGA−AA−3697−01 TCGA−AA−3693−01 TCGA−AA−3685−01 TCGA−AA−3681−01 TCGA−AA−3667−01 TCGA−AA−3666−01 TCGA−AA−3660−01 TCGA−AA−3562−01 TCGA−AA−3561−01 TCGA−AA−3560−01 TCGA−AA−3556−01 TCGA−AA−3553−01 TCGA−AA−3552−01 TCGA−AA−3549−01 TCGA−AA−3542−01 TCGA−AA−3531−01 TCGA−AA−3526−01 TCGA−AA−3524−01 TCGA−AA−3520−01 TCGA−AA−3519−01 TCGA−AA−3517−01 TCGA−AA−3511−01 TCGA−AA−3492−01 TCGA−A6−6782−01 TCGA−A6−6652−01 TCGA−A6−6651−01 TCGA−A6−6649−01 TCGA−A6−6142−01 TCGA−A6−6138−01 TCGA−A6−6137−01 TCGA−A6−5662−01 TCGA−A6−4105−01 TCGA−A6−3810−01 TCGA−A6−3807−01 TCGA−A6−2683−01 TCGA−A6−2678−01 TCGA−A6−2674−01 TCGA−A6−2670−01

BARD1 Signaling Events FDR = 1.9e−12%, FDR nod = 5.2e−05% ATR Signaling Pathway FDR = 8.7e−07%, FDR nod = 0.00038%

wt wt BAX

TCGA−AA−3950−01 TCGA−G4−6588−01 TCGA−A6−6653−01 TCGA−AA−3947−01 TCGA−AA−3870−01 TCGA−AD−6895−01 TCGA−AA−3872−01 TCGA−AA−3855−01 TCGA−AG−3892−01 TCGA−AD−6889−01 TCGA−A6−6780−01 TCGA−CM−6674−01 TCGA−F5−6811−01 TCGA−AA−3994−01 TCGA−AA−3984−01 TCGA−A6−6141−01 TCGA−AD−6964−01 TCGA−D5−6928−01 TCGA−AA−3973−01 TCGA−AA−3877−01 TCGA−AA−3864−01 TCGA−AZ−4315−01 TCGA−CM−6678−01 TCGA−CM−5861−01 TCGA−AG−3574−01 TCGA−AA−3966−01 TCGA−A6−2677−01 TCGA−AG−A002−01 TCGA−CM−5344−01 TCGA−AA−A01R−01 TCGA−AA−A00O−01 TCGA−AA−3710−01 TCGA−AA−3696−01 TCGA−AA−3672−01 TCGA−AA−3516−01 TCGA−AA−3510−01 TCGA−AA−A010−01 TCGA−G4−6628−01 TCGA−D5−6927−01 TCGA−CM−6162−01 TCGA−CM−4743−01 TCGA−CK−5916−01 TCGA−AZ−6601−01 TCGA−AG−3598−01 TCGA−AA−3949−01 TCGA−G4−6315−01 TCGA−G4−6304−01 TCGA−G4−6293−01 TCGA−F5−6464−01 TCGA−F4−6856−01 TCGA−DY−A0XA−01 TCGA−D5−6930−01 TCGA−CM−6161−01 TCGA−CM−5862−01 TCGA−CM−4752−01 TCGA−CK−4947−01 TCGA−CA−6718−01 TCGA−CA−6717−01 TCGA−AZ−6598−01 TCGA−AY−6197−01 TCGA−AU−3779−01 TCGA−AG−A036−01 TCGA−AG−4007−01 TCGA−AG−3601−01 TCGA−AD−5900−01 TCGA−AA−A01D−01 TCGA−AA−3979−01 TCGA−AA−3972−01 TCGA−AA−3869−01 TCGA−AA−3866−01 TCGA−AA−3844−01 TCGA−AA−3815−01 TCGA−AA−3811−01 TCGA−AA−3663−01 TCGA−A6−5665−01 TCGA−A6−5656−01 TCGA−G5−6235−01 TCGA−G4−6626−01 TCGA−G4−6625−01 TCGA−G4−6586−01 TCGA−G4−6323−01 TCGA−G4−6321−01 TCGA−G4−6317−01 TCGA−G4−6310−01 TCGA−G4−6307−01 TCGA−G4−6306−01 TCGA−G4−6303−01 TCGA−G4−6299−01 TCGA−F5−6813−01 TCGA−F5−6812−01 TCGA−F5−6702−01 TCGA−F5−6571−01 TCGA−F4−6854−01 TCGA−F4−6808−01 TCGA−F4−6807−01 TCGA−F4−6806−01 TCGA−F4−6805−01 TCGA−F4−6704−01 TCGA−F4−6703−01 TCGA−F4−6460−01 TCGA−F4−6459−01 TCGA−EI−6510−01 TCGA−EI−6508−01 TCGA−EI−6507−01 TCGA−EI−6506−01 TCGA−EF−5830−01 TCGA−DY−A1DG−01 TCGA−DY−A1DF−01 TCGA−DY−A1DD−01 TCGA−DY−A1DC−01 TCGA−DT−5265−01 TCGA−DM−A28K−01 TCGA−DM−A28H−01 TCGA−DM−A28F−01 TCGA−DM−A28E−01 TCGA−DM−A285−01 TCGA−DM−A1HA−01 TCGA−DM−A1DB−01 TCGA−DM−A1DA−01 TCGA−DM−A1D9−01 TCGA−DM−A1D8−01 TCGA−DM−A1D7−01 TCGA−DM−A1D6−01 TCGA−DM−A1D4−01 TCGA−DM−A1D0−01 TCGA−DM−A0XF−01 TCGA−DM−A0XD−01 TCGA−DC−6683−01 TCGA−DC−6682−01 TCGA−DC−6158−01 TCGA−DC−6157−01 TCGA−DC−6155−01 TCGA−DC−5869−01 TCGA−DC−5337−01 TCGA−D5−6932−01 TCGA−D5−6931−01 TCGA−D5−6929−01 TCGA−D5−6926−01 TCGA−D5−6924−01 TCGA−D5−6923−01 TCGA−D5−6922−01 TCGA−D5−6920−01 TCGA−D5−6898−01 TCGA−D5−6541−01 TCGA−D5−6540−01 TCGA−D5−6539−01 TCGA−D5−6538−01 TCGA−D5−6535−01 TCGA−D5−6533−01 TCGA−D5−6532−01 TCGA−D5−5541−01 TCGA−D5−5540−01 TCGA−D5−5538−01 TCGA−CM−6679−01 TCGA−CM−6677−01 TCGA−CM−6676−01 TCGA−CM−6675−01 TCGA−CM−6172−01 TCGA−CM−6171−01 TCGA−CM−6169−01 TCGA−CM−6168−01 TCGA−CM−6166−01 TCGA−CM−6165−01 TCGA−CM−6164−01 TCGA−CM−6163−01 TCGA−CM−5868−01 TCGA−CM−5864−01 TCGA−CM−5860−01 TCGA−CM−5349−01 TCGA−CM−5348−01 TCGA−CM−5341−01 TCGA−CM−4746−01 TCGA−CM−4744−01 TCGA−CL−5918−01 TCGA−CL−5917−01 TCGA−CK−5914−01 TCGA−CK−4952−01 TCGA−CK−4950−01 TCGA−CK−4948−01 TCGA−CI−6624−01 TCGA−CI−6622−01 TCGA−CI−6621−01 TCGA−CI−6620−01 TCGA−CI−6619−01 TCGA−CA−6719−01 TCGA−CA−6716−01 TCGA−CA−5797−01 TCGA−AZ−6608−01 TCGA−AZ−6607−01 TCGA−AZ−6605−01 TCGA−AZ−6600−01 TCGA−AZ−6599−01 TCGA−AZ−5407−01 TCGA−AZ−5403−01 TCGA−AZ−4616−01 TCGA−AZ−4323−01 TCGA−AY−6196−01 TCGA−AY−5543−01 TCGA−AY−4071−01 TCGA−AY−4070−01 TCGA−AU−6004−01 TCGA−AH−6643−01 TCGA−AH−6544−01 TCGA−AG−A032−01 TCGA−AG−A02X−01 TCGA−AG−A02N−01 TCGA−AG−A026−01 TCGA−AG−A020−01 TCGA−AG−A01Y−01 TCGA−AG−A01W−01 TCGA−AG−A01L−01 TCGA−AG−A016−01 TCGA−AG−A014−01 TCGA−AG−A011−01 TCGA−AG−A00Y−01 TCGA−AG−A00C−01 TCGA−AG−4015−01 TCGA−AG−4008−01 TCGA−AG−4005−01 TCGA−AG−3999−01 TCGA−AG−3909−01 TCGA−AG−3902−01 TCGA−AG−3898−01 TCGA−AG−3896−01 TCGA−AG−3893−01 TCGA−AG−3890−01 TCGA−AG−3885−01 TCGA−AG−3882−01 TCGA−AG−3742−01 TCGA−AG−3732−01 TCGA−AG−3731−01 TCGA−AG−3726−01 TCGA−AG−3612−01 TCGA−AG−3611−01 TCGA−AG−3609−01 TCGA−AG−3608−01 TCGA−AG−3605−01 TCGA−AG−3602−01 TCGA−AG−3594−01 TCGA−AG−3587−01 TCGA−AG−3581−01 TCGA−AG−3578−01 TCGA−AG−3575−01 TCGA−AF−6672−01 TCGA−AF−6655−01 TCGA−AF−6136−01 TCGA−AF−4110−01 TCGA−AF−3913−01 TCGA−AF−3400−01 TCGA−AF−2693−01 TCGA−AF−2691−01 TCGA−AF−2689−01 TCGA−AF−2687−01 TCGA−AD−6965−01 TCGA−AD−6963−01 TCGA−AD−6901−01 TCGA−AD−6899−01 TCGA−AD−6888−01 TCGA−AD−6548−01 TCGA−AA−A03J−01 TCGA−AA−A02W−01 TCGA−AA−A02J−01 TCGA−AA−A02H−01 TCGA−AA−A02F−01 TCGA−AA−A01Z−01 TCGA−AA−A01T−01 TCGA−AA−A01S−01 TCGA−AA−A01K−01 TCGA−AA−A01G−01 TCGA−AA−A01F−01 TCGA−AA−A00W−01 TCGA−AA−A00L−01 TCGA−AA−A00F−01 TCGA−AA−A00E−01 TCGA−AA−A00D−01 TCGA−AA−3982−01 TCGA−AA−3980−01 TCGA−AA−3977−01 TCGA−AA−3976−01 TCGA−AA−3975−01 TCGA−AA−3956−01 TCGA−AA−3930−01 TCGA−AA−3875−01 TCGA−AA−3867−01 TCGA−AA−3860−01 TCGA−AA−3858−01 TCGA−AA−3856−01 TCGA−AA−3851−01 TCGA−AA−3848−01 TCGA−AA−3842−01 TCGA−AA−3814−01 TCGA−AA−3713−01 TCGA−AA−3712−01 TCGA−AA−3697−01 TCGA−AA−3693−01 TCGA−AA−3685−01 TCGA−AA−3681−01 TCGA−AA−3679−01 TCGA−AA−3667−01 TCGA−AA−3666−01 TCGA−AA−3662−01 TCGA−AA−3660−01 TCGA−AA−3655−01 TCGA−AA−3562−01 TCGA−AA−3561−01 TCGA−AA−3560−01 TCGA−AA−3558−01 TCGA−AA−3556−01 TCGA−AA−3553−01 TCGA−AA−3552−01 TCGA−AA−3549−01 TCGA−AA−3542−01 TCGA−AA−3531−01 TCGA−AA−3526−01 TCGA−AA−3524−01 TCGA−AA−3520−01 TCGA−AA−3519−01 TCGA−AA−3517−01 TCGA−AA−3511−01 TCGA−AA−3492−01 TCGA−A6−6782−01 TCGA−A6−6654−01 TCGA−A6−6652−01 TCGA−A6−6651−01 TCGA−A6−6649−01 TCGA−A6−6142−01 TCGA−A6−6138−01 TCGA−A6−6137−01 TCGA−A6−5662−01 TCGA−A6−5659−01 TCGA−A6−4105−01 TCGA−A6−3810−01 TCGA−A6−3807−01 TCGA−A6−2683−01 TCGA−A6−2678−01 TCGA−A6−2676−01 TCGA−A6−2674−01 TCGA−A6−2670−01

TCGA−A6−5657−01 TCGA−CA−5796−01 TCGA−AD−6895−01 TCGA−AA−3864−01 TCGA−AA−3554−01 TCGA−CM−5344−01 TCGA−AA−A00O−01 TCGA−AA−3696−01 TCGA−AA−3672−01 TCGA−CM−6674−01 TCGA−AA−3715−01 TCGA−AA−3833−01 TCGA−A6−5666−01 TCGA−AG−A002−01 TCGA−G4−6588−01 TCGA−CK−6746−01 TCGA−AA−3966−01 TCGA−AA−3516−01 TCGA−A6−6781−01 TCGA−D5−6928−01 TCGA−D5−6536−01 TCGA−CM−6170−01 TCGA−CM−5861−01 TCGA−AG−3892−01 TCGA−AA−A01R−01 TCGA−AA−A00N−01 TCGA−AA−3950−01 TCGA−AA−3710−01 TCGA−AA−3510−01 TCGA−AA−3502−01 TCGA−AA−3496−01 TCGA−A6−6653−01 TCGA−A6−6141−01 TCGA−G5−6641−01 TCGA−G4−6309−01 TCGA−F4−6809−01 TCGA−F4−6570−01 TCGA−DY−A1H8−01 TCGA−DM−A28G−01 TCGA−DM−A28C−01 TCGA−D5−7000−01 TCGA−D5−6537−01 TCGA−D5−6529−01 TCGA−D5−5539−01 TCGA−CM−6680−01 TCGA−CK−6751−01 TCGA−CK−6748−01 TCGA−CK−5913−01 TCGA−CK−5912−01 TCGA−CA−6715−01 TCGA−AZ−6603−01 TCGA−AZ−4682−01 TCGA−AZ−4315−01 TCGA−AG−3727−01 TCGA−AG−3600−01 TCGA−AD−6890−01 TCGA−AD−6889−01 TCGA−AA−A02Y−01 TCGA−AA−A022−01 TCGA−AA−3984−01 TCGA−AA−3861−01 TCGA−AA−3819−01 TCGA−AA−3678−01 TCGA−AA−3664−01 TCGA−AA−3555−01 TCGA−AA−3530−01 TCGA−AA−3527−01 TCGA−AA−3522−01 TCGA−AA−3518−01 TCGA−A6−6780−01 TCGA−A6−5664−01 TCGA−A6−5661−01 TCGA−A6−5660−01 TCGA−CA−6717−01 TCGA−AA−A010−01 TCGA−G4−6293−01 TCGA−AA−3977−01 TCGA−G4−6628−01 TCGA−D5−5538−01 TCGA−CM−4752−01 TCGA−CA−6718−01 TCGA−AA−3713−01 TCGA−AA−3663−01 TCGA−G4−6317−01 TCGA−G4−6315−01 TCGA−G4−6304−01 TCGA−F4−6856−01 TCGA−EI−6507−01 TCGA−DY−A0XA−01 TCGA−DC−6155−01 TCGA−D5−6927−01 TCGA−D5−6540−01 TCGA−CM−5862−01 TCGA−CM−5349−01 TCGA−CM−4743−01 TCGA−CK−4952−01 TCGA−CK−4947−01 TCGA−AZ−6601−01 TCGA−AZ−6599−01 TCGA−AY−6196−01 TCGA−AU−6004−01 TCGA−AU−3779−01 TCGA−AD−6901−01 TCGA−AA−3811−01 TCGA−AA−3697−01 TCGA−AA−3492−01 TCGA−A6−5665−01 TCGA−G5−6235−01 TCGA−G4−6586−01 TCGA−G4−6321−01 TCGA−G4−6307−01 TCGA−G4−6306−01 TCGA−G4−6299−01 TCGA−F5−6813−01 TCGA−F5−6702−01 TCGA−F5−6464−01 TCGA−F4−6854−01 TCGA−F4−6808−01 TCGA−F4−6807−01 TCGA−F4−6703−01 TCGA−EI−6508−01 TCGA−EI−6506−01 TCGA−EF−5830−01 TCGA−DY−A1DF−01 TCGA−DY−A1DC−01 TCGA−DM−A28K−01 TCGA−DM−A28H−01 TCGA−DM−A28F−01 TCGA−DM−A28E−01 TCGA−DM−A1DB−01 TCGA−DM−A1DA−01 TCGA−DM−A1D4−01 TCGA−DM−A0XF−01 TCGA−DC−6683−01 TCGA−DC−5337−01 TCGA−D5−6930−01 TCGA−D5−6929−01 TCGA−D5−6924−01 TCGA−D5−6923−01 TCGA−D5−6920−01 TCGA−D5−6898−01 TCGA−D5−6541−01 TCGA−D5−6539−01 TCGA−D5−6538−01 TCGA−D5−6535−01 TCGA−D5−6533−01 TCGA−D5−6532−01 TCGA−D5−5540−01 TCGA−CM−6679−01 TCGA−CM−6677−01 TCGA−CM−6171−01 TCGA−CM−6164−01 TCGA−CM−6162−01 TCGA−CM−5868−01 TCGA−CM−5864−01 TCGA−CM−5860−01 TCGA−CM−5348−01 TCGA−CM−5341−01 TCGA−CL−5917−01 TCGA−CK−5916−01 TCGA−CK−5914−01 TCGA−CA−6719−01 TCGA−AZ−6608−01 TCGA−AZ−6598−01 TCGA−AZ−5407−01 TCGA−AZ−5403−01 TCGA−AY−6197−01 TCGA−AH−6643−01 TCGA−AH−6544−01 TCGA−AG−A036−01 TCGA−AG−A02N−01 TCGA−AG−3885−01 TCGA−AG−3742−01 TCGA−AG−3731−01 TCGA−AF−6655−01 TCGA−AF−2693−01 TCGA−AD−6963−01 TCGA−AD−6899−01 TCGA−AD−6548−01 TCGA−AA−A00E−01 TCGA−AA−3979−01 TCGA−AA−3860−01 TCGA−AA−3712−01 TCGA−AA−3679−01 TCGA−AA−3662−01 TCGA−AA−3660−01 TCGA−AA−3655−01 TCGA−AA−3517−01 TCGA−A6−4105−01 TCGA−G4−6626−01 TCGA−G4−6625−01 TCGA−G4−6323−01 TCGA−G4−6310−01 TCGA−G4−6303−01 TCGA−F5−6812−01 TCGA−F5−6571−01 TCGA−F4−6806−01 TCGA−F4−6805−01 TCGA−F4−6704−01 TCGA−F4−6460−01 TCGA−F4−6459−01 TCGA−EI−6510−01 TCGA−DY−A1DG−01 TCGA−DY−A1DD−01 TCGA−DT−5265−01 TCGA−DM−A285−01 TCGA−DM−A1HA−01 TCGA−DM−A1D9−01 TCGA−DM−A1D8−01 TCGA−DM−A1D7−01 TCGA−DM−A1D6−01 TCGA−DM−A1D0−01 TCGA−DM−A0XD−01 TCGA−DC−6682−01 TCGA−DC−6158−01 TCGA−DC−6157−01 TCGA−DC−5869−01 TCGA−D5−6932−01 TCGA−D5−6931−01 TCGA−D5−6926−01 TCGA−D5−6922−01 TCGA−D5−5541−01 TCGA−CM−6676−01 TCGA−CM−6675−01 TCGA−CM−6172−01 TCGA−CM−6169−01 TCGA−CM−6168−01 TCGA−CM−6166−01 TCGA−CM−6165−01 TCGA−CM−6163−01 TCGA−CM−6161−01 TCGA−CM−4746−01 TCGA−CM−4744−01 TCGA−CL−5918−01 TCGA−CK−4950−01 TCGA−CK−4948−01 TCGA−CI−6624−01 TCGA−CI−6622−01 TCGA−CI−6621−01 TCGA−CI−6620−01 TCGA−CI−6619−01 TCGA−CA−6716−01 TCGA−CA−5797−01 TCGA−AZ−6607−01 TCGA−AZ−6605−01 TCGA−AZ−6600−01 TCGA−AZ−4616−01 TCGA−AZ−4323−01 TCGA−AY−5543−01 TCGA−AY−4071−01 TCGA−AY−4070−01 TCGA−AG−A032−01 TCGA−AG−A02X−01 TCGA−AG−A026−01 TCGA−AG−A020−01 TCGA−AG−A01Y−01 TCGA−AG−A01W−01 TCGA−AG−A01L−01 TCGA−AG−A016−01 TCGA−AG−A014−01 TCGA−AG−A011−01 TCGA−AG−A00Y−01 TCGA−AG−A00C−01 TCGA−AG−4015−01 TCGA−AG−4008−01 TCGA−AG−4007−01 TCGA−AG−4005−01 TCGA−AG−3999−01 TCGA−AG−3909−01 TCGA−AG−3902−01 TCGA−AG−3898−01 TCGA−AG−3896−01 TCGA−AG−3893−01 TCGA−AG−3890−01 TCGA−AG−3882−01 TCGA−AG−3732−01 TCGA−AG−3726−01 TCGA−AG−3612−01 TCGA−AG−3611−01 TCGA−AG−3609−01 TCGA−AG−3608−01 TCGA−AG−3605−01 TCGA−AG−3602−01 TCGA−AG−3601−01 TCGA−AG−3598−01 TCGA−AG−3594−01 TCGA−AG−3587−01 TCGA−AG−3581−01 TCGA−AG−3578−01 TCGA−AG−3575−01 TCGA−AF−6672−01 TCGA−AF−6136−01 TCGA−AF−4110−01 TCGA−AF−3913−01 TCGA−AF−3400−01 TCGA−AF−2691−01 TCGA−AF−2689−01 TCGA−AF−2687−01 TCGA−AD−6965−01 TCGA−AD−6888−01 TCGA−AD−5900−01 TCGA−AA−A03J−01 TCGA−AA−A02W−01 TCGA−AA−A02J−01 TCGA−AA−A02H−01 TCGA−AA−A02F−01 TCGA−AA−A01Z−01 TCGA−AA−A01T−01 TCGA−AA−A01S−01 TCGA−AA−A01K−01 TCGA−AA−A01G−01 TCGA−AA−A01F−01 TCGA−AA−A01D−01 TCGA−AA−A00W−01 TCGA−AA−A00L−01 TCGA−AA−A00F−01 TCGA−AA−A00D−01 TCGA−AA−3982−01 TCGA−AA−3980−01 TCGA−AA−3976−01 TCGA−AA−3975−01 TCGA−AA−3972−01 TCGA−AA−3956−01 TCGA−AA−3949−01 TCGA−AA−3930−01 TCGA−AA−3875−01 TCGA−AA−3869−01 TCGA−AA−3867−01 TCGA−AA−3866−01 TCGA−AA−3858−01 TCGA−AA−3856−01 TCGA−AA−3851−01 TCGA−AA−3848−01 TCGA−AA−3844−01 TCGA−AA−3842−01 TCGA−AA−3815−01 TCGA−AA−3814−01 TCGA−AA−3693−01 TCGA−AA−3685−01 TCGA−AA−3681−01 TCGA−AA−3667−01 TCGA−AA−3666−01 TCGA−AA−3562−01 TCGA−AA−3561−01 TCGA−AA−3560−01 TCGA−AA−3558−01 TCGA−AA−3556−01 TCGA−AA−3553−01 TCGA−AA−3552−01 TCGA−AA−3549−01 TCGA−AA−3542−01 TCGA−AA−3531−01 TCGA−AA−3526−01 TCGA−AA−3524−01 TCGA−AA−3520−01 TCGA−AA−3519−01 TCGA−AA−3511−01 TCGA−A6−6782−01 TCGA−A6−6654−01 TCGA−A6−6652−01 TCGA−A6−6651−01 TCGA−A6−6649−01 TCGA−A6−6142−01 TCGA−A6−6138−01 TCGA−A6−6137−01 TCGA−A6−5662−01 TCGA−A6−5659−01 TCGA−A6−5656−01 TCGA−A6−3810−01 TCGA−A6−3807−01 TCGA−A6−2683−01 TCGA−A6−2678−01 TCGA−A6−2676−01 TCGA−A6−2674−01 TCGA−A6−2670−01

ATF 2 Transcription Factor Network FDR = 7e−08%, FDR nod = 0.00047% TP53 Regulates Transcription Of Genes Involved In G2 Cell Cycle Arrest FDR = 1.9e−12%, FDR nod = 0.011%

NF1 RB1 PDGFRA EP300 ESR1 BRCA1 COL24A1 MMP2 CCNA2 CUL3 DUSP10 NOS2 PPARGC1A SERPINB5 CDK4 CXCL8 DUSP1 IL6 PRKCA ARG1 ATF2 BCL2L1 CCND1 CSRP2 H2AFY IFNG KAT5 MAPK1 MAPK14 MAPK3 MAPK9 SELE ACHE ATF3 BCL2 CBFB CREB1 DDIT3 DUSP5 DUSP8 FOS HBG2 HES1 JUN JUNB MAPK8 PLAU POU2F1 RUVBL2 SOCS3 TGFB2 TH RBL2

IGFBP3 APAF1

wt PPP1R13B wt TP63

TP53 TP53

known HCG mut TP63 known HCG mut ATM


TCGA−AA−3525−01 TCGA−AA−3852−01 TCGA−A6−2671−01 TCGA−CM−5344−01 TCGA−CK−6747−01 TCGA−AA−3696−01 TCGA−AA−3994−01 TCGA−AA−3877−01 TCGA−D5−5537−01 TCGA−F5−6465−01 TCGA−AA−3688−01 TCGA−AA−3812−01 TCGA−AA−3672−01 TCGA−CM−6674−01 TCGA−CM−5863−01 TCGA−CK−5915−01 TCGA−AA−3554−01 TCGA−AA−A00J−01 TCGA−AA−3947−01 TCGA−D5−6534−01 TCGA−AA−3845−01 TCGA−AA−3543−01 TCGA−DC−6160−01 TCGA−CA−5255−01 TCGA−AH−6549−01 TCGA−A6−6648−01 TCGA−AA−3864−01 TCGA−AA−3715−01 TCGA−AD−6964−01 TCGA−AD−6895−01 TCGA−A6−3809−01 TCGA−AA−A01P−01 TCGA−A6−5666−01 TCGA−A6−5657−01 TCGA−AG−A002−01 TCGA−AA−3984−01 TCGA−AG−3892−01 TCGA−G4−6588−01 TCGA−CK−6746−01 TCGA−AZ−4315−01 TCGA−AD−6889−01 TCGA−AA−A00N−01 TCGA−F4−6570−01 TCGA−AA−3510−01 TCGA−A6−6781−01 TCGA−A6−6780−01 TCGA−A6−6653−01 TCGA−D5−6928−01 TCGA−CK−6751−01 TCGA−A6−6141−01 TCGA−D5−6536−01 TCGA−CM−5861−01 TCGA−AA−3496−01 TCGA−DY−A1H8−01 TCGA−D5−6537−01 TCGA−CM−6680−01 TCGA−CM−6170−01 TCGA−CK−6748−01 TCGA−CK−5913−01 TCGA−CK−5912−01 TCGA−CA−6715−01 TCGA−AA−3966−01 TCGA−AA−3950−01 TCGA−AA−3678−01 TCGA−AA−3664−01 TCGA−AA−3502−01 TCGA−A6−5661−01 TCGA−G5−6641−01 TCGA−G4−6309−01 TCGA−F4−6809−01 TCGA−DM−A28G−01 TCGA−DM−A28C−01 TCGA−D5−7000−01 TCGA−D5−6529−01 TCGA−D5−5539−01 TCGA−AZ−6603−01 TCGA−AZ−4682−01 TCGA−AG−3727−01 TCGA−AG−3600−01 TCGA−AD−6890−01 TCGA−AA−A02Y−01 TCGA−AA−A022−01 TCGA−AA−A01R−01 TCGA−AA−3861−01 TCGA−AA−3819−01 TCGA−AA−3710−01 TCGA−AA−3555−01 TCGA−AA−3530−01 TCGA−AA−3527−01 TCGA−AA−3522−01 TCGA−AA−3518−01 TCGA−AA−3516−01 TCGA−A6−5664−01 TCGA−A6−5660−01 TCGA−CA−6717−01 TCGA−AA−A010−01 TCGA−AA−3492−01 TCGA−G4−6628−01 TCGA−CM−4743−01 TCGA−CA−6718−01 TCGA−AA−3977−01 TCGA−AA−3663−01 TCGA−F4−6856−01 TCGA−CM−6171−01 TCGA−AZ−6598−01 TCGA−AY−6197−01 TCGA−A6−5665−01 TCGA−G4−6317−01 TCGA−G4−6306−01 TCGA−EF−5830−01 TCGA−CM−5862−01 TCGA−CK−4952−01 TCGA−AA−3811−01 TCGA−AA−3713−01 TCGA−G4−6625−01 TCGA−G4−6315−01 TCGA−G4−6293−01 TCGA−DY−A1DF−01 TCGA−DM−A28H−01 TCGA−DM−A1D6−01 TCGA−D5−6540−01 TCGA−D5−6535−01 TCGA−D5−6532−01 TCGA−D5−5538−01 TCGA−CM−5864−01 TCGA−CM−5348−01 TCGA−AZ−6608−01 TCGA−AZ−6601−01 TCGA−AU−6004−01 TCGA−AD−5900−01 TCGA−A6−2676−01 TCGA−G5−6235−01 TCGA−G4−6586−01 TCGA−G4−6307−01 TCGA−G4−6304−01 TCGA−G4−6299−01 TCGA−F5−6702−01 TCGA−F4−6854−01 TCGA−F4−6808−01 TCGA−EI−6507−01 TCGA−EI−6506−01 TCGA−DM−A28K−01 TCGA−DM−A285−01 TCGA−DC−5337−01 TCGA−D5−6927−01 TCGA−D5−6533−01 TCGA−CM−6677−01 TCGA−CM−6161−01 TCGA−CM−5860−01 TCGA−CM−5349−01 TCGA−CM−4746−01 TCGA−CL−5917−01 TCGA−CK−5916−01 TCGA−CK−4950−01 TCGA−CK−4948−01 TCGA−CK−4947−01 TCGA−AZ−6607−01 TCGA−AZ−6599−01 TCGA−AZ−5407−01 TCGA−AU−3779−01 TCGA−AG−A02N−01 TCGA−AG−3742−01 TCGA−AD−6963−01 TCGA−AD−6901−01 TCGA−AA−3815−01 TCGA−AA−3662−01 TCGA−AA−3655−01 TCGA−A6−5659−01 TCGA−G4−6321−01 TCGA−G4−6303−01 TCGA−F5−6813−01 TCGA−F4−6807−01 TCGA−F4−6806−01 TCGA−F4−6703−01 TCGA−EI−6508−01 TCGA−DY−A1DC−01 TCGA−DY−A0XA−01 TCGA−DM−A28F−01 TCGA−DM−A28E−01 TCGA−DM−A1DB−01 TCGA−DM−A1D9−01 TCGA−DM−A1D8−01 TCGA−DM−A1D4−01 TCGA−DM−A0XF−01 TCGA−DM−A0XD−01 TCGA−DC−6683−01 TCGA−DC−6155−01 TCGA−D5−6931−01 TCGA−D5−6930−01 TCGA−D5−6929−01 TCGA−D5−6926−01 TCGA−D5−6924−01 TCGA−D5−6923−01 TCGA−D5−6920−01 TCGA−D5−6898−01 TCGA−D5−6541−01 TCGA−D5−6539−01 TCGA−D5−6538−01 TCGA−D5−5540−01 TCGA−CM−6679−01 TCGA−CM−6676−01 TCGA−CM−6675−01 TCGA−CM−6172−01 TCGA−CM−6166−01 TCGA−CM−6165−01 TCGA−CM−6164−01 TCGA−CM−6162−01 TCGA−CM−5868−01 TCGA−CM−4752−01 TCGA−CK−5914−01 TCGA−CI−6619−01 TCGA−CA−6719−01 TCGA−CA−5797−01 TCGA−AZ−6600−01 TCGA−AZ−5403−01 TCGA−AY−6196−01 TCGA−AY−4070−01 TCGA−AH−6643−01 TCGA−AH−6544−01 TCGA−AG−A011−01 TCGA−AG−A00Y−01 TCGA−AG−3999−01 TCGA−AG−3885−01 TCGA−AG−3732−01 TCGA−AG−3731−01 TCGA−AG−3601−01 TCGA−AF−6672−01 TCGA−AF−6655−01 TCGA−AF−4110−01 TCGA−AF−2693−01 TCGA−AD−6899−01 TCGA−AD−6888−01 TCGA−AD−6548−01 TCGA−AA−A02F−01 TCGA−AA−A00E−01 TCGA−AA−3982−01 TCGA−AA−3949−01 TCGA−AA−3930−01 TCGA−AA−3860−01 TCGA−AA−3712−01 TCGA−AA−3697−01 TCGA−AA−3679−01 TCGA−AA−3660−01 TCGA−AA−3531−01 TCGA−A6−6782−01 TCGA−A6−6138−01 TCGA−A6−5656−01 TCGA−A6−4105−01 TCGA−A6−3807−01 TCGA−G4−6626−01 TCGA−G4−6323−01 TCGA−G4−6310−01 TCGA−F5−6812−01 TCGA−F5−6571−01 TCGA−F5−6464−01 TCGA−F4−6805−01 TCGA−F4−6704−01 TCGA−F4−6460−01 TCGA−F4−6459−01 TCGA−EI−6510−01 TCGA−DY−A1DG−01 TCGA−DY−A1DD−01 TCGA−DT−5265−01 TCGA−DM−A1HA−01 TCGA−DM−A1DA−01 TCGA−DM−A1D7−01 TCGA−DM−A1D0−01 TCGA−DC−6682−01 TCGA−DC−6158−01 TCGA−DC−6157−01 TCGA−DC−5869−01 TCGA−D5−6932−01 TCGA−D5−6922−01 TCGA−D5−5541−01 TCGA−CM−6169−01 TCGA−CM−6168−01 TCGA−CM−6163−01 TCGA−CM−5341−01 TCGA−CM−4744−01 TCGA−CL−5918−01 TCGA−CI−6624−01 TCGA−CI−6622−01 TCGA−CI−6621−01 TCGA−CI−6620−01 TCGA−CA−6716−01 TCGA−AZ−6605−01 TCGA−AZ−4616−01 TCGA−AZ−4323−01 TCGA−AY−5543−01 TCGA−AY−4071−01 TCGA−AG−A036−01 TCGA−AG−A032−01 TCGA−AG−A02X−01 TCGA−AG−A026−01 TCGA−AG−A020−01 TCGA−AG−A01Y−01 TCGA−AG−A01W−01 TCGA−AG−A01L−01 TCGA−AG−A016−01 TCGA−AG−A014−01 TCGA−AG−A00C−01 TCGA−AG−4015−01 TCGA−AG−4008−01 TCGA−AG−4007−01 TCGA−AG−4005−01 TCGA−AG−3909−01 TCGA−AG−3902−01 TCGA−AG−3898−01 TCGA−AG−3896−01 TCGA−AG−3893−01 TCGA−AG−3890−01 TCGA−AG−3882−01 TCGA−AG−3726−01 TCGA−AG−3612−01 TCGA−AG−3611−01 TCGA−AG−3609−01 TCGA−AG−3608−01 TCGA−AG−3605−01 TCGA−AG−3602−01 TCGA−AG−3598−01 TCGA−AG−3594−01 TCGA−AG−3587−01 TCGA−AG−3581−01 TCGA−AG−3578−01 TCGA−AG−3575−01 TCGA−AF−6136−01 TCGA−AF−3913−01 TCGA−AF−3400−01 TCGA−AF−2691−01 TCGA−AF−2689−01 TCGA−AF−2687−01 TCGA−AD−6965−01 TCGA−AA−A03J−01 TCGA−AA−A02W−01 TCGA−AA−A02J−01 TCGA−AA−A02H−01 TCGA−AA−A01Z−01 TCGA−AA−A01T−01 TCGA−AA−A01S−01 TCGA−AA−A01K−01 TCGA−AA−A01G−01 TCGA−AA−A01F−01 TCGA−AA−A01D−01 TCGA−AA−A00W−01 TCGA−AA−A00L−01 TCGA−AA−A00F−01 TCGA−AA−A00D−01 TCGA−AA−3980−01 TCGA−AA−3979−01 TCGA−AA−3976−01 TCGA−AA−3975−01 TCGA−AA−3972−01 TCGA−AA−3956−01 TCGA−AA−3875−01 TCGA−AA−3869−01 TCGA−AA−3867−01 TCGA−AA−3866−01 TCGA−AA−3858−01 TCGA−AA−3856−01 TCGA−AA−3851−01 TCGA−AA−3848−01 TCGA−AA−3844−01 TCGA−AA−3842−01 TCGA−AA−3814−01 TCGA−AA−3693−01 TCGA−AA−3685−01 TCGA−AA−3681−01 TCGA−AA−3667−01 TCGA−AA−3666−01 TCGA−AA−3562−01 TCGA−AA−3561−01 TCGA−AA−3560−01 TCGA−AA−3558−01 TCGA−AA−3556−01 TCGA−AA−3553−01 TCGA−AA−3552−01 TCGA−AA−3549−01 TCGA−AA−3542−01 TCGA−AA−3526−01 TCGA−AA−3524−01 TCGA−AA−3520−01 TCGA−AA−3519−01 TCGA−AA−3517−01 TCGA−AA−3511−01 TCGA−A6−6654−01 TCGA−A6−6652−01 TCGA−A6−6651−01 TCGA−A6−6649−01 TCGA−A6−6142−01 TCGA−A6−6137−01 TCGA−A6−5662−01 TCGA−A6−3810−01 TCGA−A6−2683−01 TCGA−A6−2678−01 TCGA−A6−2674−01 TCGA−A6−2670−01

TCGA−CM−4746−01 TCGA−CI−6621−01 TCGA−AA−3511−01 TCGA−AG−3896−01 TCGA−DM−A1DB−01 TCGA−AA−A01Q−01 TCGA−DM−A1HA−01 TCGA−A6−2678−01 TCGA−AZ−6603−01 TCGA−D5−6924−01 TCGA−AA−A022−01 TCGA−AA−3966−01 TCGA−A6−5657−01 TCGA−AA−3678−01 TCGA−F5−6813−01 TCGA−AG−3583−01 TCGA−CM−6674−01 TCGA−EI−6510−01 TCGA−DM−A0XF−01 TCGA−F4−6570−01 TCGA−AG−3883−01 TCGA−AG−3727−01 TCGA−AG−3608−01 TCGA−G4−6309−01 TCGA−AA−3950−01 TCGA−D5−6920−01 TCGA−AA−A004−01 TCGA−CK−4952−01 TCGA−AA−A02O−01 TCGA−AA−3846−01 TCGA−AA−3514−01 TCGA−G4−6304−01 TCGA−AA−3516−01 TCGA−AA−A01V−01 TCGA−AA−A01T−01 TCGA−G4−6317−01 TCGA−F4−6856−01 TCGA−CM−6170−01 TCGA−AF−6672−01 TCGA−A6−2671−01 TCGA−AA−3877−01 TCGA−DY−A1DD−01 TCGA−D5−6927−01 TCGA−AG−3574−01 TCGA−A6−5659−01 TCGA−AA−3949−01 TCGA−DY−A1H8−01 TCGA−DY−A1DF−01 TCGA−CM−6171−01 TCGA−AA−3815−01 TCGA−F5−6811−01 TCGA−CA−5796−01 TCGA−AH−6544−01 TCGA−AG−3732−01 TCGA−A6−5666−01 TCGA−AA−3492−01 TCGA−AA−3672−01 TCGA−AH−6644−01 TCGA−AA−A01P−01 TCGA−AA−A00R−01 TCGA−AA−3955−01 TCGA−AA−3939−01 TCGA−A6−6653−01 TCGA−D5−6928−01 TCGA−AD−5900−01 TCGA−AA−3558−01 TCGA−AA−A03J−01 TCGA−AA−A00E−01 TCGA−AA−3525−01 TCGA−AD−6889−01 TCGA−D5−6535−01 TCGA−AD−6895−01 TCGA−CK−5916−01 TCGA−AA−A01R−01 TCGA−AA−3994−01 TCGA−AA−3555−01 TCGA−A6−4105−01 TCGA−D5−7000−01 TCGA−AU−3779−01 TCGA−AA−3833−01 TCGA−CK−6746−01 TCGA−AA−3947−01 TCGA−A6−6780−01 TCGA−DM−A1D6−01 TCGA−AZ−5407−01 TCGA−G4−6306−01 TCGA−CM−5862−01 TCGA−CK−4950−01 TCGA−AA−A00J−01 TCGA−F5−6702−01 TCGA−DM−A1D8−01 TCGA−D5−6534−01 TCGA−D5−6532−01 TCGA−CK−6748−01 TCGA−AZ−6607−01 TCGA−AD−6963−01 TCGA−AD−6888−01 TCGA−AA−A02F−01 TCGA−AA−3845−01 TCGA−A6−6138−01 TCGA−CM−5348−01 TCGA−AZ−6600−01 TCGA−CA−6716−01 TCGA−G4−6626−01 TCGA−CK−4948−01 TCGA−CA−5797−01 TCGA−A6−6651−01 TCGA−A6−6141−01 TCGA−G4−6586−01 TCGA−F4−6809−01 TCGA−F4−6569−01 TCGA−DM−A282−01 TCGA−DM−A0X9−01 TCGA−DC−5869−01 TCGA−D5−6538−01 TCGA−CM−6166−01 TCGA−CI−6619−01 TCGA−AG−3885−01 TCGA−AA−A02J−01 TCGA−AA−A00A−01 TCGA−A6−6782−01 TCGA−A6−6142−01 TCGA−AA−3984−01 TCGA−AA−3864−01 TCGA−A6−6781−01 TCGA−AY−6197−01 TCGA−AA−3977−01 TCGA−G4−6293−01 TCGA−EF−5830−01 TCGA−CK−6751−01 TCGA−AZ−6608−01 TCGA−A6−6648−01 TCGA−G4−6299−01 TCGA−DM−A285−01 TCGA−DC−5337−01 TCGA−D5−6931−01 TCGA−D5−5538−01 TCGA−CK−5912−01 TCGA−AA−3664−01 TCGA−A6−2676−01 TCGA−G4−6315−01 TCGA−F4−6808−01 TCGA−F4−6806−01 TCGA−DC−6160−01 TCGA−CM−6675−01 TCGA−CM−6165−01 TCGA−CL−5917−01 TCGA−CA−5255−01 TCGA−AY−4070−01 TCGA−AH−6549−01 TCGA−AD−6901−01 TCGA−AA−3811−01 TCGA−AA−3543−01 TCGA−AA−3502−01 TCGA−AG−A002−01 TCGA−CA−6717−01 TCGA−AA−A010−01 TCGA−G4−6588−01 TCGA−AZ−6598−01 TCGA−CA−6718−01 TCGA−AA−3713−01 TCGA−AZ−4315−01 TCGA−AU−6004−01 TCGA−AG−3892−01 TCGA−AA−3663−01 TCGA−AA−3510−01 TCGA−AA−A00N−01 TCGA−A6−5665−01 TCGA−AZ−6601−01 TCGA−AD−6964−01 TCGA−D5−6540−01 TCGA−D5−6536−01 TCGA−CM−6162−01 TCGA−CM−5861−01 TCGA−CM−4743−01 TCGA−CK−5913−01 TCGA−AA−3715−01 TCGA−AA−3662−01 TCGA−AA−3496−01 TCGA−A6−6654−01 TCGA−G4−6628−01 TCGA−G4−6307−01 TCGA−F4−6703−01 TCGA−F4−6460−01 TCGA−DY−A1DG−01 TCGA−D5−6930−01 TCGA−D5−6926−01 TCGA−D5−6533−01 TCGA−CM−6678−01 TCGA−CM−6172−01 TCGA−CI−6624−01 TCGA−AZ−6599−01 TCGA−AA−3712−01 TCGA−AA−3710−01 TCGA−AA−3518−01 TCGA−EI−6508−01 TCGA−EI−6507−01 TCGA−DM−A1D9−01 TCGA−DM−A0XD−01 TCGA−DC−6155−01 TCGA−D5−6929−01 TCGA−D5−6923−01 TCGA−CM−6679−01 TCGA−CM−6677−01 TCGA−CM−5868−01 TCGA−CM−5863−01 TCGA−CM−4752−01 TCGA−CI−6622−01 TCGA−CA−6715−01 TCGA−AH−6643−01 TCGA−AG−A00C−01 TCGA−AG−3601−01 TCGA−AF−5654−01 TCGA−AA−3697−01 TCGA−AA−3562−01 TCGA−A6−5656−01

FOXA1 Transcription Factor Network FDR = 2.3e−06%, FDR nod = 0.015% DNA Damage/Telomere Stress Induced Senescence FDR = 1.9e−12%, FDR nod = 0.14%

TCGA−AG−3887−01 TCGA−DM−A0XF−01 TCGA−AG−4001−01 TCGA−CM−6172−01 TCGA−G4−6310−01 TCGA−CL−5917−01 TCGA−DT−5265−01 TCGA−AA−3664−01 TCGA−DC−6160−01 TCGA−AG−A016−01 TCGA−DY−A0XA−01 TCGA−AA−A02O−01 TCGA−AG−3902−01 TCGA−A6−4105−01 TCGA−AA−3532−01 TCGA−AA−3530−01 TCGA−CM−4747−01 TCGA−AG−3882−01 TCGA−AA−3693−01 TCGA−AG−A025−01 TCGA−D5−6533−01 TCGA−AG−3612−01 TCGA−AA−3842−01 TCGA−CM−4746−01 TCGA−F4−6703−01 TCGA−AG−A014−01 TCGA−AA−3989−01 TCGA−AA−3855−01 TCGA−A6−2676−01 TCGA−AH−6644−01 TCGA−AG−A036−01 TCGA−AA−3520−01 TCGA−A6−3808−01 TCGA−CM−6674−01 TCGA−D5−6922−01 TCGA−AA−A02J−01 TCGA−AA−3521−01 TCGA−AA−3663−01 TCGA−DM−A282−01 TCGA−D5−5539−01 TCGA−AA−3844−01 TCGA−AA−3660−01 TCGA−G4−6315−01 TCGA−CI−6621−01 TCGA−AA−3982−01 TCGA−AA−3949−01 TCGA−AA−3858−01 TCGA−AA−3821−01 TCGA−F4−6856−01 TCGA−F4−6569−01 TCGA−DM−A28E−01 TCGA−DM−A1DB−01 TCGA−CA−5254−01 TCGA−AA−A00O−01 TCGA−AA−3956−01 TCGA−CA−6718−01 TCGA−G4−6321−01 TCGA−AF−2693−01 TCGA−AA−3666−01 TCGA−A6−5661−01 TCGA−CK−4950−01 TCGA−AG−3898−01 TCGA−AG−3896−01 TCGA−AA−3697−01 TCGA−AA−3492−01 TCGA−F4−6570−01 TCGA−DM−A1D6−01 TCGA−CK−4952−01 TCGA−AY−6197−01 TCGA−AA−3496−01 TCGA−G4−6317−01 TCGA−EI−6506−01 TCGA−CM−5864−01 TCGA−CM−5862−01 TCGA−A6−6782−01 TCGA−A6−3809−01 TCGA−D5−6928−01 TCGA−AA−A01R−01 TCGA−AA−3977−01 TCGA−G4−6309−01 TCGA−CI−6624−01 TCGA−DM−A28F−01 TCGA−CK−5916−01 TCGA−AA−3678−01 TCGA−F4−6809−01 TCGA−F4−6459−01 TCGA−D5−6930−01 TCGA−D5−6541−01 TCGA−D5−6537−01 TCGA−D5−6534−01 TCGA−AZ−6603−01 TCGA−AZ−4682−01 TCGA−AD−6899−01 TCGA−AA−3930−01 TCGA−AA−3867−01 TCGA−AA−3712−01 TCGA−A6−5666−01 TCGA−A6−6781−01 TCGA−AD−6889−01 TCGA−A6−6653−01 TCGA−AA−3655−01 TCGA−D5−6539−01 TCGA−D5−5540−01 TCGA−CM−6162−01 TCGA−AF−2687−01 TCGA−AA−3527−01 TCGA−G5−6641−01 TCGA−G5−6235−01 TCGA−G4−6323−01 TCGA−F5−6813−01 TCGA−DC−6682−01 TCGA−CM−5868−01 TCGA−CM−4752−01 TCGA−CA−5796−01 TCGA−AY−6386−01 TCGA−AG−3732−01 TCGA−AA−A01G−01 TCGA−AA−A00R−01 TCGA−AA−3554−01 TCGA−A6−6141−01 TCGA−A6−5659−01 TCGA−AZ−6598−01 TCGA−AG−3892−01 TCGA−AA−A00N−01 TCGA−A6−6780−01 TCGA−D5−6927−01 TCGA−AA−A01Q−01 TCGA−CK−5913−01 TCGA−CI−6619−01 TCGA−AZ−5403−01 TCGA−AA−3950−01 TCGA−AA−3525−01 TCGA−F4−6854−01 TCGA−EF−5830−01 TCGA−DM−A1D0−01 TCGA−DM−A0X9−01 TCGA−D5−6931−01 TCGA−CM−5860−01 TCGA−CA−6716−01 TCGA−CA−5797−01 TCGA−AA−A00J−01 TCGA−AA−3710−01 TCGA−AA−3555−01 TCGA−F4−6855−01 TCGA−D5−6538−01 TCGA−CM−5348−01 TCGA−CK−5914−01 TCGA−CK−4947−01 TCGA−CA−6719−01 TCGA−AZ−6607−01 TCGA−AY−6196−01 TCGA−AG−4005−01 TCGA−AG−3742−01 TCGA−AG−3602−01 TCGA−AF−6672−01 TCGA−AF−5654−01 TCGA−AA−A02F−01 TCGA−AA−A01P−01 TCGA−AA−A00U−01 TCGA−AA−3556−01 TCGA−AA−3549−01 TCGA−AA−3489−01 TCGA−A6−5662−01 TCGA−A6−2672−01 TCGA−AG−A002−01 TCGA−CA−6717−01 TCGA−AA−A010−01 TCGA−AZ−4315−01 TCGA−CK−6746−01 TCGA−G4−6588−01 TCGA−AZ−6601−01 TCGA−AA−A022−01 TCGA−AA−3510−01 TCGA−CM−6171−01 TCGA−AA−3984−01 TCGA−AA−3815−01 TCGA−D5−6540−01 TCGA−AU−6004−01 TCGA−AA−3947−01 TCGA−AA−3715−01 TCGA−G4−6628−01 TCGA−EI−6507−01 TCGA−D5−5538−01 TCGA−CM−5861−01 TCGA−CM−4743−01 TCGA−AG−A02N−01 TCGA−AA−3877−01 TCGA−G4−6307−01 TCGA−AZ−6599−01 TCGA−AD−6964−01 TCGA−AD−5900−01 TCGA−AA−3662−01 TCGA−A6−5665−01 TCGA−G4−6586−01 TCGA−G4−6304−01 TCGA−G4−6293−01 TCGA−F4−6808−01 TCGA−F4−6460−01 TCGA−EI−6510−01 TCGA−DM−A1DA−01 TCGA−D5−6535−01 TCGA−D5−5537−01 TCGA−CM−6680−01 TCGA−CM−6168−01 TCGA−CK−4948−01 TCGA−AY−5543−01 TCGA−AH−6643−01 TCGA−AA−A00E−01 TCGA−AA−3864−01 TCGA−AA−3713−01 TCGA−G4−6625−01 TCGA−F5−6812−01 TCGA−DM−A28H−01 TCGA−DM−A1HA−01 TCGA−DM−A1D8−01 TCGA−DM−A1D7−01 TCGA−D5−6923−01 TCGA−CM−6164−01 TCGA−CM−5349−01 TCGA−CM−5344−01 TCGA−CI−6620−01 TCGA−AU−3779−01 TCGA−AH−6549−01 TCGA−AH−6544−01 TCGA−AG−3731−01 TCGA−AD−6963−01 TCGA−AA−A029−01 TCGA−AA−3973−01 TCGA−AA−3966−01 TCGA−AA−3818−01 TCGA−AA−3811−01 TCGA−AA−3672−01 TCGA−AA−3518−01 TCGA−AA−3516−01

TCGA−D5−6534−01 TCGA−AG−4001−01 TCGA−AA−3821−01 TCGA−AA−3715−01 TCGA−AA−3812−01 TCGA−AG−A025−01 TCGA−AD−6895−01 TCGA−AA−3994−01 TCGA−AA−A01V−01 TCGA−AG−A00H−01 TCGA−AA−A00R−01 TCGA−AA−A00J−01 TCGA−AA−3877−01 TCGA−AA−3947−01 TCGA−CM−5344−01 TCGA−AA−3845−01 TCGA−CM−6674−01 TCGA−CM−5863−01 TCGA−CK−5915−01 TCGA−AA−3554−01 TCGA−A6−3809−01 TCGA−AA−3672−01 TCGA−F5−6465−01 TCGA−AA−3864−01 TCGA−AA−3850−01 TCGA−AY−6386−01 TCGA−AG−A015−01 TCGA−AG−3599−01 TCGA−AA−A01Q−01 TCGA−A6−2672−01 TCGA−AG−A002−01 TCGA−CM−5861−01 TCGA−AG−3892−01 TCGA−AA−3516−01 TCGA−A6−5661−01 TCGA−CK−6746−01 TCGA−AA−A00N−01 TCGA−AA−3510−01 TCGA−G4−6588−01 TCGA−D5−6928−01 TCGA−AA−A01R−01 TCGA−AA−3984−01 TCGA−AA−3555−01 TCGA−F4−6809−01 TCGA−F4−6570−01 TCGA−DY−A1H8−01 TCGA−D5−7000−01 TCGA−D5−6536−01 TCGA−CM−6680−01 TCGA−CM−6170−01 TCGA−CK−5913−01 TCGA−AZ−6603−01 TCGA−AZ−4315−01 TCGA−AA−3710−01 TCGA−A6−6781−01 TCGA−A6−6653−01 TCGA−A6−6141−01 TCGA−G5−6641−01 TCGA−G4−6309−01 TCGA−DM−A28G−01 TCGA−DM−A28C−01 TCGA−D5−6537−01 TCGA−D5−6529−01 TCGA−D5−5539−01 TCGA−CK−6751−01 TCGA−CK−6748−01 TCGA−CK−5912−01 TCGA−CA−6715−01 TCGA−AZ−4682−01 TCGA−AG−3727−01 TCGA−AG−3600−01 TCGA−AD−6890−01 TCGA−AD−6889−01 TCGA−AA−A02Y−01 TCGA−AA−A022−01 TCGA−AA−3966−01 TCGA−AA−3950−01 TCGA−AA−3861−01 TCGA−AA−3819−01 TCGA−AA−3678−01 TCGA−AA−3664−01 TCGA−AA−3530−01 TCGA−AA−3527−01 TCGA−AA−3522−01 TCGA−AA−3518−01 TCGA−AA−3502−01 TCGA−AA−3496−01 TCGA−A6−6780−01 TCGA−A6−5664−01 TCGA−A6−5660−01 TCGA−AA−A010−01 TCGA−CA−6717−01 TCGA−AZ−6598−01 TCGA−D5−6540−01 TCGA−G4−6586−01 TCGA−EI−6507−01 TCGA−CK−4952−01 TCGA−CA−6718−01 TCGA−AZ−6599−01 TCGA−AA−3977−01 TCGA−AA−3713−01 TCGA−AA−3663−01 TCGA−AA−3492−01 TCGA−G4−6628−01 TCGA−G4−6306−01 TCGA−F4−6856−01 TCGA−DY−A1DF−01 TCGA−DM−A1DB−01 TCGA−CM−6171−01 TCGA−CM−6162−01 TCGA−CM−4743−01 TCGA−AU−6004−01 TCGA−AA−3811−01 TCGA−A6−5665−01 TCGA−G4−6304−01 TCGA−G4−6293−01 TCGA−EF−5830−01 TCGA−DM−A1D4−01 TCGA−D5−6930−01 TCGA−D5−6927−01 TCGA−D5−6898−01 TCGA−D5−6532−01 TCGA−CM−6677−01 TCGA−CM−6161−01 TCGA−CM−5862−01 TCGA−CM−5349−01 TCGA−CM−5348−01 TCGA−CM−4752−01 TCGA−CK−5916−01 TCGA−CK−5914−01 TCGA−CK−4947−01 TCGA−AZ−5407−01 TCGA−AY−6197−01 TCGA−AU−3779−01 TCGA−AH−6643−01 TCGA−AG−3731−01 TCGA−AF−4110−01 TCGA−AD−6963−01 TCGA−AD−5900−01 TCGA−AA−3860−01 TCGA−A6−4105−01 TCGA−G5−6235−01 TCGA−G4−6321−01 TCGA−G4−6317−01 TCGA−G4−6315−01 TCGA−G4−6307−01 TCGA−G4−6303−01 TCGA−F5−6813−01 TCGA−F5−6812−01 TCGA−F5−6702−01 TCGA−F4−6854−01 TCGA−F4−6808−01 TCGA−F4−6807−01 TCGA−F4−6806−01 TCGA−F4−6460−01 TCGA−EI−6508−01 TCGA−EI−6506−01 TCGA−DY−A1DC−01 TCGA−DT−5265−01 TCGA−DM−A28K−01 TCGA−DM−A28H−01 TCGA−DM−A28F−01 TCGA−DM−A28E−01 TCGA−DM−A1D8−01 TCGA−DM−A1D6−01 TCGA−DM−A0XF−01 TCGA−DM−A0XD−01 TCGA−DC−6683−01 TCGA−DC−6155−01 TCGA−DC−5337−01 TCGA−D5−6929−01 TCGA−D5−6924−01 TCGA−D5−6923−01 TCGA−D5−6920−01 TCGA−D5−6541−01 TCGA−D5−6539−01 TCGA−D5−6538−01 TCGA−D5−6535−01 TCGA−D5−6533−01 TCGA−D5−5538−01 TCGA−CM−6679−01 TCGA−CM−6172−01 TCGA−CM−6164−01 TCGA−CM−5868−01 TCGA−CM−5864−01 TCGA−CM−5860−01 TCGA−CM−5341−01 TCGA−CM−4746−01 TCGA−CM−4744−01 TCGA−CL−5917−01 TCGA−CK−4950−01 TCGA−CI−6624−01 TCGA−CI−6619−01 TCGA−CA−6719−01 TCGA−AZ−6608−01 TCGA−AZ−6601−01 TCGA−AZ−6600−01 TCGA−AZ−5403−01 TCGA−AZ−4323−01 TCGA−AY−6196−01 TCGA−AY−5543−01 TCGA−AH−6544−01 TCGA−AG−A016−01 TCGA−AG−3885−01 TCGA−AG−3742−01 TCGA−AG−3732−01 TCGA−AF−6655−01 TCGA−AF−2693−01 TCGA−AF−2687−01 TCGA−AD−6901−01 TCGA−AD−6899−01 TCGA−AD−6888−01 TCGA−AD−6548−01 TCGA−AA−A01T−01 TCGA−AA−A00E−01 TCGA−AA−3949−01 TCGA−AA−3815−01 TCGA−AA−3712−01 TCGA−AA−3697−01 TCGA−AA−3693−01 TCGA−AA−3685−01 TCGA−AA−3679−01 TCGA−AA−3667−01 TCGA−AA−3662−01 TCGA−AA−3660−01 TCGA−AA−3655−01 TCGA−AA−3552−01 TCGA−AA−3511−01 TCGA−A6−6142−01 TCGA−A6−6138−01 TCGA−A6−5659−01 TCGA−A6−3807−01 TCGA−A6−2676−01 TCGA−G4−6626−01 TCGA−G4−6625−01 TCGA−G4−6323−01 TCGA−G4−6310−01 TCGA−G4−6299−01 TCGA−F5−6571−01 TCGA−F5−6464−01 TCGA−F4−6805−01 TCGA−F4−6704−01 TCGA−F4−6703−01 TCGA−F4−6459−01 TCGA−EI−6510−01 TCGA−DY−A1DG−01 TCGA−DY−A1DD−01 TCGA−DY−A0XA−01 TCGA−DM−A285−01 TCGA−DM−A1HA−01 TCGA−DM−A1DA−01 TCGA−DM−A1D9−01 TCGA−DM−A1D7−01 TCGA−DM−A1D0−01 TCGA−DC−6682−01 TCGA−DC−6158−01 TCGA−DC−6157−01 TCGA−DC−5869−01 TCGA−D5−6932−01 TCGA−D5−6931−01 TCGA−D5−6926−01 TCGA−D5−6922−01 TCGA−D5−5541−01 TCGA−D5−5540−01 TCGA−CM−6676−01 TCGA−CM−6675−01 TCGA−CM−6169−01 TCGA−CM−6168−01 TCGA−CM−6166−01 TCGA−CM−6165−01 TCGA−CM−6163−01 TCGA−CL−5918−01 TCGA−CK−4948−01 TCGA−CI−6622−01 TCGA−CI−6621−01 TCGA−CI−6620−01 TCGA−CA−6716−01 TCGA−CA−5797−01 TCGA−AZ−6607−01 TCGA−AZ−6605−01 TCGA−AZ−4616−01 TCGA−AY−4071−01 TCGA−AY−4070−01 TCGA−AG−A036−01 TCGA−AG−A032−01 TCGA−AG−A02X−01 TCGA−AG−A02N−01 TCGA−AG−A026−01 TCGA−AG−A020−01 TCGA−AG−A01Y−01 TCGA−AG−A01W−01 TCGA−AG−A01L−01 TCGA−AG−A014−01 TCGA−AG−A011−01 TCGA−AG−A00Y−01 TCGA−AG−A00C−01 TCGA−AG−4015−01 TCGA−AG−4008−01 TCGA−AG−4007−01 TCGA−AG−4005−01 TCGA−AG−3999−01 TCGA−AG−3909−01 TCGA−AG−3902−01 TCGA−AG−3898−01 TCGA−AG−3896−01 TCGA−AG−3893−01 TCGA−AG−3890−01 TCGA−AG−3882−01 TCGA−AG−3726−01 TCGA−AG−3612−01 TCGA−AG−3611−01 TCGA−AG−3609−01 TCGA−AG−3608−01 TCGA−AG−3605−01 TCGA−AG−3602−01 TCGA−AG−3601−01 TCGA−AG−3598−01 TCGA−AG−3594−01 TCGA−AG−3587−01 TCGA−AG−3581−01 TCGA−AG−3578−01 TCGA−AG−3575−01 TCGA−AF−6672−01 TCGA−AF−6136−01 TCGA−AF−3913−01 TCGA−AF−3400−01 TCGA−AF−2691−01 TCGA−AF−2689−01 TCGA−AD−6965−01 TCGA−AA−A03J−01 TCGA−AA−A02W−01 TCGA−AA−A02J−01 TCGA−AA−A02H−01 TCGA−AA−A02F−01 TCGA−AA−A01Z−01 TCGA−AA−A01S−01 TCGA−AA−A01K−01 TCGA−AA−A01G−01 TCGA−AA−A01F−01 TCGA−AA−A01D−01 TCGA−AA−A00W−01 TCGA−AA−A00L−01 TCGA−AA−A00F−01 TCGA−AA−A00D−01 TCGA−AA−3982−01 TCGA−AA−3980−01 TCGA−AA−3979−01 TCGA−AA−3976−01 TCGA−AA−3975−01 TCGA−AA−3972−01 TCGA−AA−3956−01 TCGA−AA−3930−01 TCGA−AA−3875−01 TCGA−AA−3869−01 TCGA−AA−3867−01 TCGA−AA−3866−01 TCGA−AA−3858−01 TCGA−AA−3856−01 TCGA−AA−3851−01 TCGA−AA−3848−01 TCGA−AA−3844−01 TCGA−AA−3842−01 TCGA−AA−3814−01 TCGA−AA−3681−01 TCGA−AA−3666−01 TCGA−AA−3562−01 TCGA−AA−3561−01 TCGA−AA−3560−01 TCGA−AA−3558−01 TCGA−AA−3556−01 TCGA−AA−3553−01 TCGA−AA−3549−01 TCGA−AA−3542−01 TCGA−AA−3531−01 TCGA−AA−3526−01 TCGA−AA−3524−01 TCGA−AA−3520−01 TCGA−AA−3519−01 TCGA−AA−3517−01 TCGA−A6−6782−01 TCGA−A6−6654−01 TCGA−A6−6652−01 TCGA−A6−6651−01 TCGA−A6−6649−01 TCGA−A6−6137−01 TCGA−A6−5662−01 TCGA−A6−5656−01 TCGA−A6−3810−01 TCGA−A6−2683−01 TCGA−A6−2678−01 TCGA−A6−2674−01 TCGA−A6−2670−01


TCGA−AG−4007−01 TCGA−AG−3885−01 TCGA−AA−3667−01 TCGA−AA−A02J−01 TCGA−AZ−4616−01 TCGA−A6−3808−01 TCGA−AA−3994−01 TCGA−AZ−5407−01 TCGA−AA−A01K−01 TCGA−AZ−6606−01 TCGA−DT−5265−01 TCGA−AA−3664−01 TCGA−G4−6309−01 TCGA−AA−3855−01 TCGA−DM−A28K−01 TCGA−A6−5660−01 TCGA−AA−3812−01 TCGA−AA−3552−01 TCGA−AA−A01V−01 TCGA−AA−A01T−01 TCGA−AG−A011−01 TCGA−DC−6157−01 TCGA−AA−3693−01 TCGA−F4−6459−01 TCGA−CA−5255−01 TCGA−AA−3869−01 TCGA−AY−6196−01 TCGA−AA−3514−01 TCGA−A6−2672−01 TCGA−CK−5914−01 TCGA−AG−A00H−01 TCGA−AA−A02K−01 TCGA−AA−A01Z−01 TCGA−EI−6506−01 TCGA−DM−A282−01 TCGA−CM−6163−01 TCGA−AA−3553−01 TCGA−CI−6621−01 TCGA−AA−3982−01 TCGA−AA−3949−01 TCGA−AA−3858−01 TCGA−AA−3492−01 TCGA−AA−A01P−01 TCGA−DC−5337−01 TCGA−AH−6644−01 TCGA−AA−3955−01 TCGA−AA−3939−01 TCGA−D5−6928−01 TCGA−DM−A1D6−01 TCGA−CA−6716−01 TCGA−DC−6681−01 TCGA−D5−6541−01 TCGA−D5−6529−01 TCGA−CM−4746−01 TCGA−AZ−6608−01 TCGA−A6−6781−01 TCGA−D5−6931−01 TCGA−A6−6653−01 TCGA−G5−6641−01 TCGA−F5−6813−01 TCGA−DM−A1D0−01 TCGA−DC−6682−01 TCGA−AY−6386−01 TCGA−A6−5659−01 TCGA−G5−6235−01 TCGA−D5−5540−01 TCGA−CA−5796−01 TCGA−AG−3732−01 TCGA−AA−A01G−01 TCGA−AA−3554−01 TCGA−AA−3527−01 TCGA−AA−3977−01 TCGA−G4−6303−01 TCGA−AA−A01Q−01 TCGA−AA−A00R−01 TCGA−AA−3555−01 TCGA−AA−A00J−01 TCGA−AA−3525−01 TCGA−F4−6569−01 TCGA−AG−3902−01 TCGA−AF−6136−01 TCGA−AF−2687−01 TCGA−AA−3660−01 TCGA−A6−3809−01 TCGA−A6−2676−01 TCGA−F4−6856−01 TCGA−CM−6675−01 TCGA−CK−6751−01 TCGA−CK−6747−01 TCGA−AA−A02O−01 TCGA−AA−3845−01 TCGA−A6−6648−01 TCGA−AA−A00N−01 TCGA−CA−6718−01 TCGA−AA−3663−01 TCGA−CM−5868−01 TCGA−CK−5913−01 TCGA−A6−5656−01 TCGA−D5−6930−01 TCGA−D5−6929−01 TCGA−CI−6622−01 TCGA−AG−3892−01 TCGA−AA−3712−01 TCGA−A6−6654−01 TCGA−F4−6703−01 TCGA−EI−6508−01 TCGA−DY−A1DG−01 TCGA−DM−A1D9−01 TCGA−DC−6155−01 TCGA−D5−6926−01 TCGA−D5−6536−01 TCGA−CM−6679−01 TCGA−CM−6677−01 TCGA−CM−5863−01 TCGA−CI−6624−01 TCGA−CA−6715−01 TCGA−AG−A00C−01 TCGA−AG−3601−01 TCGA−AF−5654−01 TCGA−AA−3710−01 TCGA−AA−3562−01 TCGA−AZ−4315−01 TCGA−CM−5861−01 TCGA−AA−3815−01 TCGA−AD−5900−01 TCGA−G4−6628−01 TCGA−EI−6507−01 TCGA−AD−6964−01 TCGA−AA−3984−01 TCGA−AA−3864−01 TCGA−AA−3518−01 TCGA−G4−6307−01 TCGA−F4−6460−01 TCGA−AG−A02N−01 TCGA−AA−A022−01 TCGA−AA−3877−01 TCGA−F4−6808−01 TCGA−DM−A1HA−01 TCGA−DM−A1DA−01 TCGA−DM−A1D8−01 TCGA−DM−A1D7−01 TCGA−D5−5537−01 TCGA−CK−6746−01 TCGA−AY−5543−01 TCGA−AH−6643−01 TCGA−AG−3731−01 TCGA−AA−3966−01 TCGA−AA−3947−01 TCGA−AA−3818−01 TCGA−AA−3672−01 TCGA−AA−3516−01 TCGA−CM−6680−01 TCGA−CM−6168−01 TCGA−CM−6164−01 TCGA−CK−4948−01 TCGA−AH−6544−01 TCGA−AD−6963−01 TCGA−AA−A029−01 TCGA−AA−A00E−01 TCGA−AA−3973−01 TCGA−AG−A002−01 TCGA−CA−6717−01 TCGA−AA−A010−01 TCGA−G4−6588−01 TCGA−A6−5665−01 TCGA−CM−4743−01 TCGA−AA−3510−01 TCGA−AA−3715−01 TCGA−D5−6540−01 TCGA−AZ−6601−01 TCGA−AZ−6598−01 TCGA−CM−4752−01 TCGA−CK−4952−01 TCGA−AA−3662−01 TCGA−G4−6586−01 TCGA−EI−6510−01 TCGA−CM−6162−01 TCGA−AZ−6599−01 TCGA−AU−6004−01 TCGA−AD−6895−01 TCGA−AD−6889−01 TCGA−AA−3713−01 TCGA−A6−6780−01 TCGA−A6−5661−01 TCGA−G4−6304−01 TCGA−G4−6293−01 TCGA−F4−6570−01 TCGA−D5−6927−01 TCGA−D5−6923−01 TCGA−D5−6539−01 TCGA−D5−6535−01 TCGA−D5−5538−01 TCGA−CM−6674−01 TCGA−CM−6172−01 TCGA−AD−6901−01 TCGA−AA−3811−01 TCGA−A6−6141−01 TCGA−G4−6625−01 TCGA−G4−6323−01 TCGA−G4−6321−01 TCGA−G4−6317−01 TCGA−G4−6315−01 TCGA−G4−6306−01 TCGA−F5−6812−01 TCGA−DM−A28H−01 TCGA−DM−A0XD−01 TCGA−D5−7000−01 TCGA−D5−6932−01 TCGA−D5−6898−01 TCGA−D5−6533−01 TCGA−D5−6532−01 TCGA−CM−6678−01 TCGA−CM−6171−01 TCGA−CM−5349−01 TCGA−CM−5344−01 TCGA−CK−4950−01 TCGA−CI−6620−01 TCGA−CI−6619−01 TCGA−CA−6719−01 TCGA−AZ−6603−01 TCGA−AY−6197−01 TCGA−AU−3779−01 TCGA−AH−6549−01 TCGA−AG−3881−01 TCGA−AA−3697−01 TCGA−AA−3655−01 TCGA−AA−3502−01 TCGA−AA−3496−01 TCGA−G4−6299−01 TCGA−F5−6464−01 TCGA−F4−6806−01 TCGA−DY−A1H8−01 TCGA−DY−A0XA−01 TCGA−DM−A28G−01 TCGA−DM−A28F−01 TCGA−DM−A28C−01 TCGA−DM−A1D4−01 TCGA−D5−6534−01 TCGA−D5−5539−01 TCGA−CM−6676−01 TCGA−CM−6169−01 TCGA−CM−6165−01 TCGA−CM−6161−01 TCGA−CM−5860−01 TCGA−CM−5348−01 TCGA−CM−5341−01 TCGA−CM−4747−01 TCGA−CA−5797−01 TCGA−AZ−6600−01 TCGA−AZ−4323−01 TCGA−AG−3742−01 TCGA−AF−6672−01 TCGA−AF−4110−01 TCGA−AF−2693−01 TCGA−AA−3968−01 TCGA−A6−6652−01 TCGA−A6−6649−01 TCGA−A6−6142−01 TCGA−A6−5666−01 TCGA−A6−5662−01 TCGA−A6−4105−01

HDR Through Homologous Recombination (HRR) FDR = 2.3e−12%, FDR nod = 0.51% Gap Filling DNA Repair Synthesis And Ligation In GG NER FDR = 0.002%, FDR nod = 0.0016%

RFC1

wt

RPA1

XRCC1

RPA3

POLD3

RFC2

RFC5

UBC

POLD2

POLE2

RFC4

RPA2

UBA52

wt PCNA

wt

LIG1

POLE

POLD1


POLK

wt wt


ATM BRCA2 POLE BRCA1 PALB2 BLM RAD50 TOP3A WRN BARD1 PCNA POLD1 BRIP1 DNA2 RPA1 RPA3 UBC EXO1 KAT5 POLD2 POLD3 POLK RAD51B RAD51D RBBP8 RFC1 RFC4 RFC5 XRCC2 MRE11A NBN POLE2 POLH RAD51AP1 RAD51C RFC2 RMI1 RMI2 RPA2 UBA52 XRCC3 LIG3

known HCG mut


unknown CG mut

known HCG mut

wt


RB1 CREBBP BRCA2 CENPF EP300 CHEK2 PLK1 ESR1 LAMA4 XRCC1 CDC25B GSK3A NFATC3 CCNA2 HIST1H2BA MYC SKP2 SP1 BIRC5 CCNB1 CCNB2 CDK2 CDK4 ETV5 FOXM1 HSPA1B MMP2 AURKB CCND1 CCNE1 CDK1 CDKN2A CENPA CENPB CKS1B FOS HSPA1A MAP2K1 NEK2 ONECUT1

unknown CG mut


FOXM1 Transcription Factor Network FDR = 1.9e−12%, FDR nod = 2.3e−11%

unknown CG mut CREBBP APOB EP300 DSCAM BRCA1 AR NCOA3 ESR1 FOXA2 NRIP1 PRDM15 NR2F2 SERPINA1 SFTPD CDKN1B COL18A1 NFIA NFIC NKX3−1 PISD SP1 AP1B1 CYP2C18 JUN NFIB POU2F1 C4BPB CCND1 CEBPB FOS FOXA1 FOXA3 GCG KLK3 NDUFV3 SFTPA1 SFTPA2 SHH TFF1 VTN XBP1 unknown CG mut TP53 ATM EP400 RAD50 CCNA1 CCNE1 TERF2IP CCNA2 CDK2 CDKN1A CDKN1B H2AFB1 HIST1H2AJ HIST1H2BE HIST1H2BH ACD CCNE2 H2AFX H2AFZ HIST1H2AB HIST1H2AC HIST1H2AE HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BF HIST1H2BG HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BO HIST1H4A HIST1H4B HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4L HIST2H2AA4 HIST2H2AC HIST2H2BE HIST3H2BB HIST3H3 HIST4H4 KAT5 MRE11A NBN POT1 TERF1 TERF2 TINF2

TCGA−AG−3882−01 TCGA−AA−3521−01 TCGA−CI−6621−01 TCGA−A6−6651−01 TCGA−AF−6136−01 TCGA−DY−A0XA−01 TCGA−A6−5659−01 TCGA−AA−A02J−01 TCGA−CA−5254−01 TCGA−D5−6931−01 TCGA−CM−5341−01 TCGA−AA−3667−01 TCGA−CM−5344−01 TCGA−F5−6812−01 TCGA−A6−6652−01 TCGA−CM−6676−01 TCGA−AA−3511−01 TCGA−AA−A004−01 TCGA−AA−3877−01 TCGA−AA−3845−01 TCGA−AZ−6600−01 TCGA−DT−5265−01 TCGA−D5−6922−01 TCGA−D5−6927−01 TCGA−AA−3949−01 TCGA−F5−6464−01 TCGA−F5−6465−01 TCGA−AG−3999−01 TCGA−AA−3688−01 TCGA−AA−3672−01 TCGA−AA−3812−01 TCGA−A6−2676−01 TCGA−AA−A01Q−01 TCGA−CM−6163−01 TCGA−AY−4071−01 TCGA−AA−3696−01 TCGA−G4−6299−01 TCGA−AF−2687−01 TCGA−AA−A01P−01 TCGA−AA−3980−01 TCGA−AD−5900−01 TCGA−CM−6674−01 TCGA−A6−3807−01 TCGA−AG−3732−01 TCGA−AA−3554−01 TCGA−AD−6895−01 TCGA−D5−6534−01 TCGA−A6−2672−01 TCGA−CM−4744−01 TCGA−AY−5543−01 TCGA−AA−3947−01 TCGA−CM−6161−01 TCGA−CA−6716−01 TCGA−CM−6166−01 TCGA−AA−3854−01 TCGA−AA−3543−01 TCGA−CK−5916−01 TCGA−A6−3809−01 TCGA−A6−6782−01 TCGA−DM−A1D6−01 TCGA−D5−5537−01 TCGA−CK−4948−01 TCGA−CI−6619−01 TCGA−CA−5797−01 TCGA−AA−A00E−01 TCGA−AA−3864−01 TCGA−AA−3815−01 TCGA−AA−A00J−01 TCGA−CK−5915−01 TCGA−AA−3525−01 TCGA−CM−4746−01 TCGA−G4−6303−01 TCGA−CM−6675−01 TCGA−AG−A01W−01 TCGA−AA−3833−01 TCGA−CM−6162−01 TCGA−AA−3715−01 TCGA−D5−6930−01 TCGA−AD−6964−01 TCGA−CM−6678−01 TCGA−DM−A0XD−01 TCGA−CM−5863−01 TCGA−AG−3601−01 TCGA−AA−3712−01 TCGA−F4−6703−01 TCGA−F4−6460−01 TCGA−DY−A1DG−01 TCGA−DM−A1D9−01 TCGA−D5−6926−01 TCGA−CM−6172−01 TCGA−CI−6624−01 TCGA−CI−6622−01 TCGA−AG−A00C−01 TCGA−AF−5654−01 TCGA−AA−3562−01 TCGA−A6−6654−01 TCGA−A6−5656−01 TCGA−AG−A002−01 TCGA−CA−6717−01 TCGA−AA−A010−01 TCGA−AA−A00N−01 TCGA−G4−6628−01 TCGA−AZ−4315−01 TCGA−AA−3984−01 TCGA−AZ−6598−01 TCGA−AA−3510−01 TCGA−D5−6540−01 TCGA−AA−3977−01 TCGA−AG−3892−01 TCGA−AA−3663−01 TCGA−A6−5665−01 TCGA−CM−5861−01 TCGA−CA−6718−01 TCGA−AA−3496−01 TCGA−A6−6781−01 TCGA−G4−6588−01 TCGA−F4−6570−01 TCGA−CM−4743−01 TCGA−CK−6746−01 TCGA−AZ−6601−01 TCGA−AA−3710−01 TCGA−AA−3518−01 TCGA−A6−6780−01 TCGA−G4−6309−01 TCGA−F4−6856−01 TCGA−EI−6507−01 TCGA−CM−6171−01 TCGA−AY−6197−01 TCGA−AA−3713−01 TCGA−A6−5661−01 TCGA−G4−6307−01 TCGA−CM−6677−01 TCGA−AZ−6599−01 TCGA−AD−6889−01 TCGA−AA−3966−01 TCGA−AA−3950−01 TCGA−AA−3492−01 TCGA−A6−6653−01 TCGA−A6−6141−01 TCGA−A6−4105−01 TCGA−G4−6315−01 TCGA−EI−6506−01 TCGA−EF−5830−01 TCGA−DY−A1DF−01 TCGA−D5−6928−01 TCGA−CM−5862−01 TCGA−CM−4752−01 TCGA−CK−5913−01 TCGA−CK−4952−01 TCGA−AZ−6603−01 TCGA−AA−A022−01 TCGA−AA−3660−01 TCGA−AA−3516−01 TCGA−G4−6586−01 TCGA−G4−6317−01 TCGA−F5−6813−01 TCGA−EI−6508−01 TCGA−DY−A1H8−01 TCGA−DM−A28K−01 TCGA−DM−A1D4−01 TCGA−DM−A0XF−01 TCGA−DC−6155−01 TCGA−D5−6929−01 TCGA−D5−6923−01 TCGA−D5−6920−01 TCGA−D5−6536−01 TCGA−D5−6533−01 TCGA−CM−6679−01 TCGA−CM−5868−01 TCGA−CM−5864−01 TCGA−CM−5860−01 TCGA−CM−5349−01 TCGA−CM−5348−01 TCGA−CK−6751−01 TCGA−CK−4947−01 TCGA−CA−6715−01 TCGA−AU−6004−01 TCGA−AH−6643−01 TCGA−AH−6544−01 TCGA−AG−3885−01 TCGA−AA−A01R−01 TCGA−AA−3819−01 TCGA−AA−3697−01 TCGA−AA−3678−01 TCGA−AA−3664−01 TCGA−AA−3662−01 TCGA−AA−3555−01 TCGA−AA−3527−01 TCGA−G5−6641−01 TCGA−G5−6235−01 TCGA−G4−6321−01 TCGA−G4−6306−01 TCGA−G4−6304−01 TCGA−G4−6293−01 TCGA−F5−6702−01 TCGA−F4−6854−01 TCGA−F4−6809−01 TCGA−F4−6808−01 TCGA−F4−6807−01 TCGA−DY−A1DC−01 TCGA−DM−A28H−01 TCGA−DM−A28G−01 TCGA−DM−A28F−01 TCGA−DM−A28E−01 TCGA−DM−A28C−01 TCGA−DM−A1DB−01 TCGA−DC−6683−01 TCGA−DC−5337−01 TCGA−D5−7000−01 TCGA−D5−6924−01 TCGA−D5−6898−01 TCGA−D5−6541−01 TCGA−D5−6539−01 TCGA−D5−6538−01 TCGA−D5−6537−01 TCGA−D5−6535−01 TCGA−D5−6532−01 TCGA−D5−6529−01 TCGA−D5−5539−01 TCGA−D5−5538−01 TCGA−CM−6680−01 TCGA−CM−6170−01 TCGA−CM−6164−01 TCGA−CL−5917−01 TCGA−CK−6748−01 TCGA−CK−5914−01 TCGA−CK−5912−01 TCGA−CA−6719−01 TCGA−AZ−6608−01 TCGA−AZ−5407−01 TCGA−AZ−5403−01 TCGA−AZ−4682−01 TCGA−AY−6196−01 TCGA−AU−3779−01 TCGA−AG−3742−01 TCGA−AG−3731−01 TCGA−AG−3727−01 TCGA−AG−3600−01 TCGA−AF−6655−01 TCGA−AF−2693−01 TCGA−AD−6963−01 TCGA−AD−6901−01 TCGA−AD−6899−01 TCGA−AD−6890−01 TCGA−AD−6548−01 TCGA−AA−A02Y−01 TCGA−AA−3861−01 TCGA−AA−3860−01 TCGA−AA−3811−01 TCGA−AA−3679−01 TCGA−AA−3655−01 TCGA−AA−3530−01 TCGA−AA−3522−01 TCGA−AA−3502−01 TCGA−A6−5664−01 TCGA−A6−5660−01

TCGA−A6−6651−01 TCGA−CM−5341−01 TCGA−CM−5349−01 TCGA−A6−6652−01 TCGA−CI−6621−01 TCGA−CA−6716−01 TCGA−CM−5348−01 TCGA−A6−6653−01 TCGA−DM−A1D4−01 TCGA−AA−3672−01 TCGA−CM−6676−01 TCGA−AA−3511−01 TCGA−AA−3496−01 TCGA−D5−7000−01 TCGA−D5−5537−01 TCGA−CK−5914−01 TCGA−AG−A00H−01 TCGA−G4−6309−01 TCGA−AA−3950−01 TCGA−AA−A004−01 TCGA−AA−3877−01 TCGA−AZ−6603−01 TCGA−AF−6136−01 TCGA−AA−3966−01 TCGA−AA−3845−01 TCGA−F5−6465−01 TCGA−DY−A1DF−01 TCGA−AG−3999−01 TCGA−AA−3688−01 TCGA−G4−6315−01 TCGA−EF−5830−01 TCGA−CA−5254−01 TCGA−A6−6782−01 TCGA−A6−5661−01 TCGA−D5−6927−01 TCGA−AA−3949−01 TCGA−F5−6464−01 TCGA−AA−3947−01 TCGA−AA−3516−01 TCGA−A6−6780−01 TCGA−G4−6628−01 TCGA−AA−3663−01 TCGA−AD−5900−01 TCGA−AA−3715−01 TCGA−AA−A02K−01 TCGA−AA−A01Z−01 TCGA−G4−6310−01 TCGA−CM−4743−01 TCGA−A6−2672−01 TCGA−AA−A010−01 TCGA−CM−6162−01 TCGA−AZ−4315−01 TCGA−AG−A002−01 TCGA−AA−3984−01 TCGA−A6−6781−01 TCGA−CA−6717−01 TCGA−AD−6964−01 TCGA−AA−3710−01 TCGA−CA−6718−01 TCGA−AG−3892−01 TCGA−AA−A00J−01 TCGA−AA−3977−01 TCGA−AA−3525−01 TCGA−AA−3518−01 TCGA−A6−4105−01 TCGA−DM−A28K−01 TCGA−CM−6678−01 TCGA−CM−6675−01 TCGA−CM−5861−01 TCGA−CM−4746−01 TCGA−AG−A01W−01 TCGA−AA−3833−01 TCGA−AA−3815−01 TCGA−AA−3678−01 TCGA−AA−3660−01 TCGA−AA−3555−01 TCGA−D5−6540−01 TCGA−AZ−6598−01 TCGA−AZ−6601−01 TCGA−AA−A00N−01 TCGA−D5−6930−01 TCGA−G4−6588−01 TCGA−G4−6303−01 TCGA−F4−6856−01 TCGA−EI−6507−01 TCGA−CK−5916−01 TCGA−AA−3864−01 TCGA−AA−3510−01 TCGA−A6−6141−01 TCGA−A6−5665−01 TCGA−F5−6812−01 TCGA−D5−6931−01 TCGA−D5−6928−01 TCGA−D5−6920−01 TCGA−CK−5915−01 TCGA−CK−5913−01 TCGA−CK−4952−01 TCGA−AY−6197−01 TCGA−AU−6004−01 TCGA−AA−3492−01 TCGA−G4−6306−01 TCGA−G4−6304−01 TCGA−G4−6299−01 TCGA−F4−6570−01 TCGA−F4−6460−01 TCGA−EI−6510−01 TCGA−DM−A28F−01 TCGA−DM−A1DB−01 TCGA−DM−A1D6−01 TCGA−DC−6683−01 TCGA−DC−6155−01 TCGA−DC−5337−01 TCGA−D5−6898−01 TCGA−D5−6541−01 TCGA−D5−6536−01 TCGA−D5−5540−01 TCGA−CM−6171−01 TCGA−CM−6164−01 TCGA−CL−5917−01 TCGA−CI−6624−01 TCGA−CA−6719−01 TCGA−AZ−6608−01 TCGA−AZ−6600−01 TCGA−AZ−4682−01 TCGA−AG−3732−01 TCGA−AD−6889−01 TCGA−AA−A022−01 TCGA−AA−3489−01 TCGA−A6−6138−01 TCGA−A6−6137−01 TCGA−A6−5662−01 TCGA−A6−5660−01

ATM

TCGA−AA−3525−01 TCGA−CM−6165−01 TCGA−DM−A0X9−01 TCGA−F5−6811−01 TCGA−AA−3856−01 TCGA−AA−3949−01 TCGA−AA−3667−01 TCGA−CK−4950−01 TCGA−A6−6142−01 TCGA−AZ−6600−01 TCGA−AA−3685−01 TCGA−AG−4001−01 TCGA−F5−6465−01 TCGA−AA−3552−01 TCGA−F4−6806−01 TCGA−AA−A01Q−01 TCGA−DY−A0XA−01 TCGA−CI−6624−01 TCGA−G4−6323−01 TCGA−AG−A032−01 TCGA−DM−A0XD−01 TCGA−D5−6534−01 TCGA−DY−A1DD−01 TCGA−CI−6620−01 TCGA−AA−3672−01 TCGA−AA−3812−01 TCGA−AG−3601−01 TCGA−DC−6158−01 TCGA−CA−6716−01 TCGA−AG−A00H−01 TCGA−AG−3887−01 TCGA−AA−3554−01 TCGA−CM−5863−01 TCGA−CK−5915−01 TCGA−AG−3732−01 TCGA−CM−4744−01 TCGA−AG−A016−01 TCGA−DC−6160−01 TCGA−AA−A029−01 TCGA−CM−4746−01 TCGA−AD−5900−01 TCGA−DC−5869−01 TCGA−AZ−6606−01 TCGA−AG−A025−01 TCGA−CM−6674−01 TCGA−F5−6571−01 TCGA−DC−6157−01 TCGA−CM−5341−01 TCGA−AD−6888−01 TCGA−AA−3877−01 TCGA−DM−A1D6−01 TCGA−CI−6619−01 TCGA−AA−A00E−01 TCGA−D5−5537−01 TCGA−CA−5797−01 TCGA−A6−6782−01 TCGA−AA−3712−01 TCGA−A6−3807−01 TCGA−CM−6167−01 TCGA−AY−5543−01 TCGA−AA−A00J−01 TCGA−AA−3821−01 TCGA−CI−6621−01 TCGA−AG−A036−01 TCGA−AG−3587−01 TCGA−A6−2672−01 TCGA−A6−2676−01 TCGA−D5−6930−01 TCGA−AA−3947−01 TCGA−CM−6162−01 TCGA−CK−5916−01 TCGA−AA−3696−01 TCGA−DM−A1DA−01 TCGA−AG−3909−01 TCGA−AF−5654−01 TCGA−AA−A01V−01 TCGA−AA−3972−01 TCGA−AA−3814−01 TCGA−A6−6138−01 TCGA−AA−3715−01 TCGA−D5−6927−01 TCGA−AG−A02N−01 TCGA−A6−3809−01 TCGA−AA−3815−01 TCGA−CM−6161−01 TCGA−CK−4948−01 TCGA−AD−6964−01 TCGA−AA−A01P−01 TCGA−AA−3864−01 TCGA−G4−6303−01 TCGA−D5−5540−01 TCGA−AZ−6607−01 TCGA−AD−6895−01 TCGA−G4−6625−01 TCGA−F4−6703−01 TCGA−CM−6676−01 TCGA−CM−6166−01 TCGA−AG−A011−01 TCGA−AF−4110−01 TCGA−AA−3930−01 TCGA−A6−5666−01 TCGA−A6−5659−01 TCGA−A6−5657−01 TCGA−A6−5656−01 TCGA−AG−A002−01 TCGA−AA−A010−01 TCGA−CA−6717−01 TCGA−AA−A00N−01 TCGA−G4−6588−01 TCGA−AG−3892−01 TCGA−G4−6628−01 TCGA−A6−5665−01 TCGA−AZ−6598−01 TCGA−AA−3984−01 TCGA−AA−3510−01 TCGA−G4−6586−01 TCGA−CM−4743−01 TCGA−AZ−4315−01 TCGA−AA−3811−01 TCGA−AA−3492−01 TCGA−F4−6856−01 TCGA−EI−6507−01 TCGA−CM−5861−01 TCGA−CK−6746−01 TCGA−AZ−6599−01 TCGA−AD−6889−01 TCGA−AA−3977−01 TCGA−AA−3713−01 TCGA−AA−3663−01 TCGA−A6−6781−01 TCGA−G4−6293−01 TCGA−F4−6570−01 TCGA−CK−4952−01 TCGA−CA−6718−01 TCGA−AY−6197−01 TCGA−AA−A022−01 TCGA−G4−6304−01 TCGA−D5−6928−01 TCGA−D5−6540−01 TCGA−D5−5539−01 TCGA−CM−6677−01 TCGA−CM−6171−01 TCGA−CM−5862−01 TCGA−CK−5913−01 TCGA−AZ−6601−01 TCGA−A6−6780−01 TCGA−A6−6653−01 TCGA−A6−6141−01 TCGA−A6−5661−01 TCGA−G5−6641−01 TCGA−G4−6321−01 TCGA−G4−6317−01 TCGA−G4−6306−01 TCGA−F4−6808−01 TCGA−DM−A28H−01 TCGA−DM−A1D4−01 TCGA−D5−6535−01 TCGA−D5−6533−01 TCGA−CM−5860−01 TCGA−CM−5348−01 TCGA−CM−4752−01 TCGA−AF−2693−01 TCGA−AA−3655−01 TCGA−AA−3496−01 TCGA−A6−4105−01 TCGA−G5−6235−01 TCGA−G4−6315−01 TCGA−G4−6309−01 TCGA−G4−6307−01 TCGA−F4−6854−01 TCGA−F4−6809−01 TCGA−EI−6506−01 TCGA−EF−5830−01 TCGA−DY−A1H8−01 TCGA−DY−A1DF−01 TCGA−DY−A1DC−01 TCGA−DM−A28K−01 TCGA−DM−A28E−01 TCGA−DM−A28C−01 TCGA−DM−A1DB−01 TCGA−D5−6929−01 TCGA−D5−6924−01 TCGA−D5−6898−01 TCGA−D5−6541−01 TCGA−D5−6538−01 TCGA−D5−6537−01 TCGA−D5−6536−01 TCGA−D5−6532−01 TCGA−D5−5538−01 TCGA−CM−6680−01 TCGA−CM−6170−01 TCGA−CM−5868−01 TCGA−CM−5864−01 TCGA−CM−5349−01 TCGA−CK−5914−01 TCGA−CK−4947−01 TCGA−AZ−6608−01 TCGA−AZ−6603−01 TCGA−AZ−4682−01 TCGA−AY−6196−01 TCGA−AU−6004−01 TCGA−AU−3779−01 TCGA−AH−6643−01 TCGA−AH−6544−01 TCGA−AG−3731−01 TCGA−AA−A02Y−01 TCGA−AA−A01R−01 TCGA−AA−3966−01 TCGA−AA−3950−01 TCGA−AA−3819−01 TCGA−AA−3710−01 TCGA−AA−3662−01 TCGA−AA−3555−01 TCGA−AA−3518−01 TCGA−AA−3516−01 TCGA−A6−5664−01 TCGA−F5−6813−01 TCGA−F5−6702−01 TCGA−F4−6807−01 TCGA−EI−6508−01 TCGA−DM−A28G−01 TCGA−DM−A28F−01 TCGA−DM−A0XF−01 TCGA−DC−6683−01 TCGA−DC−6155−01 TCGA−DC−5337−01 TCGA−D5−7000−01 TCGA−D5−6923−01 TCGA−D5−6920−01 TCGA−D5−6539−01 TCGA−D5−6529−01 TCGA−CM−6679−01 TCGA−CM−6164−01 TCGA−CL−5917−01 TCGA−CK−6751−01 TCGA−CK−6748−01 TCGA−CK−5912−01 TCGA−CA−6719−01 TCGA−CA−6715−01 TCGA−AZ−5407−01 TCGA−AZ−5403−01 TCGA−AG−3885−01 TCGA−AG−3742−01 TCGA−AG−3727−01 TCGA−AG−3600−01 TCGA−AF−6655−01 TCGA−AD−6963−01 TCGA−AD−6901−01 TCGA−AD−6899−01 TCGA−AD−6890−01 TCGA−AD−6548−01 TCGA−AA−3861−01 TCGA−AA−3860−01 TCGA−AA−3697−01 TCGA−AA−3679−01 TCGA−AA−3678−01 TCGA−AA−3664−01 TCGA−AA−3660−01 TCGA−AA−3530−01 TCGA−AA−3527−01 TCGA−AA−3522−01 TCGA−AA−3502−01 TCGA−A6−5660−01

TCGA−AG−A00H−01 TCGA−AA−3844−01 TCGA−AA−3855−01 TCGA−AA−3511−01 TCGA−AA−3561−01 TCGA−CK−4950−01 TCGA−AG−A016−01 TCGA−AA−3685−01 TCGA−G4−6303−01 TCGA−D5−6540−01 TCGA−DM−A1D4−01 TCGA−AA−3850−01 TCGA−D5−6541−01 TCGA−AA−3655−01 TCGA−CM−5860−01 TCGA−A6−5657−01 TCGA−DM−A1D8−01 TCGA−D5−6533−01 TCGA−DT−5265−01 TCGA−A6−6138−01 TCGA−F5−6812−01 TCGA−AF−4110−01 TCGA−CM−6170−01 TCGA−A6−6142−01 TCGA−AZ−6600−01 TCGA−AH−6643−01 TCGA−AA−3812−01 TCGA−AA−3552−01 TCGA−G4−6306−01 TCGA−A6−5659−01 TCGA−A6−6654−01 TCGA−CA−5796−01 TCGA−AA−3966−01 TCGA−AG−4001−01 TCGA−A6−5662−01 TCGA−A6−2678−01 TCGA−AA−A022−01 TCGA−AA−A00R−01 TCGA−D5−6535−01 TCGA−AA−3673−01 TCGA−AZ−5403−01 TCGA−DC−6155−01 TCGA−AG−A011−01 TCGA−AG−3896−01 TCGA−DM−A282−01 TCGA−DM−A0XD−01 TCGA−CM−6168−01 TCGA−AG−3600−01 TCGA−AA−3678−01 TCGA−A6−3807−01 TCGA−G4−6317−01 TCGA−CK−4948−01 TCGA−CI−6619−01 TCGA−A6−3809−01 TCGA−EI−6506−01 TCGA−CM−5862−01 TCGA−CK−5916−01 TCGA−F4−6570−01 TCGA−CM−6674−01 TCGA−A6−6780−01 TCGA−F5−6465−01 TCGA−G4−6625−01 TCGA−CM−5868−01 TCGA−AG−A01Y−01 TCGA−AA−A01K−01 TCGA−AA−3869−01 TCGA−A6−6653−01 TCGA−AA−A01R−01 TCGA−AA−3877−01 TCGA−AA−3821−01 TCGA−CK−5913−01 TCGA−AY−6196−01 TCGA−AA−3712−01 TCGA−AA−3662−01 TCGA−CK−5915−01 TCGA−AG−3999−01 TCGA−AZ−6601−01 TCGA−AD−6964−01 TCGA−G4−6304−01 TCGA−F4−6856−01 TCGA−DM−A1D6−01 TCGA−D5−5537−01 TCGA−CK−5914−01 TCGA−AZ−6603−01 TCGA−AA−3815−01 TCGA−F4−6855−01 TCGA−DY−A1DG−01 TCGA−AD−6548−01 TCGA−AA−3870−01 TCGA−AA−3667−01 TCGA−AA−3660−01 TCGA−AA−3713−01 TCGA−AA−3811−01 TCGA−AA−3496−01 TCGA−G4−6299−01 TCGA−F4−6806−01 TCGA−DC−6160−01 TCGA−D5−6536−01 TCGA−CM−6675−01 TCGA−CM−6172−01 TCGA−CK−5912−01 TCGA−AA−3864−01 TCGA−G4−6315−01 TCGA−G4−6293−01 TCGA−F4−6808−01 TCGA−DC−5337−01 TCGA−CM−6165−01 TCGA−CL−5917−01 TCGA−CA−5255−01 TCGA−AY−4070−01 TCGA−AH−6549−01 TCGA−AD−6901−01 TCGA−AA−3502−01 TCGA−AG−A002−01 TCGA−AA−A010−01 TCGA−CA−6717−01 TCGA−AZ−4315−01 TCGA−AA−3715−01 TCGA−AA−3510−01 TCGA−CA−6718−01 TCGA−AZ−6598−01 TCGA−AA−3492−01 TCGA−AA−A00N−01 TCGA−AA−3984−01 TCGA−AA−3977−01 TCGA−G4−6586−01 TCGA−AA−3663−01 TCGA−D5−6930−01 TCGA−AZ−6599−01 TCGA−AY−6197−01 TCGA−AG−3892−01 TCGA−AA−3555−01 TCGA−A6−6781−01 TCGA−A6−5665−01 TCGA−EI−6507−01 TCGA−D5−6928−01 TCGA−CM−6162−01 TCGA−CM−4743−01 TCGA−AA−3710−01 TCGA−AA−3672−01 TCGA−AA−3516−01 TCGA−A6−5661−01 TCGA−G4−6588−01 TCGA−D5−6927−01 TCGA−CM−6171−01 TCGA−CM−5861−01 TCGA−AD−6895−01 TCGA−AD−6889−01 TCGA−AD−5900−01 TCGA−A6−6141−01 TCGA−G4−6309−01 TCGA−F4−6809−01 TCGA−EF−5830−01 TCGA−DM−A28F−01 TCGA−D5−6931−01 TCGA−CK−6751−01 TCGA−CK−4952−01 TCGA−CI−6624−01 TCGA−AU−6004−01 TCGA−AG−A02N−01 TCGA−AG−3731−01 TCGA−AA−A01Q−01 TCGA−AA−3950−01 TCGA−AA−3949−01 TCGA−AA−3518−01 TCGA−A6−6782−01 TCGA−A6−6648−01 TCGA−A6−2676−01 TCGA−G4−6628−01 TCGA−DY−A1DF−01 TCGA−DM−A285−01 TCGA−DM−A1DB−01 TCGA−DM−A0XF−01 TCGA−D5−5538−01 TCGA−CM−6680−01 TCGA−CM−6678−01 TCGA−CM−6161−01 TCGA−CM−5864−01 TCGA−CM−5348−01 TCGA−CM−4746−01 TCGA−CK−6746−01 TCGA−CA−6716−01 TCGA−CA−5797−01 TCGA−AZ−6608−01 TCGA−AZ−5407−01 TCGA−AZ−4323−01 TCGA−AY−5543−01 TCGA−AG−3894−01 TCGA−AG−3732−01 TCGA−AF−6672−01 TCGA−AF−2687−01 TCGA−AD−6890−01 TCGA−AA−A00E−01 TCGA−AA−3875−01 TCGA−AA−3845−01 TCGA−AA−3833−01 TCGA−AA−3697−01 TCGA−AA−3693−01 TCGA−AA−3664−01 TCGA−AA−3558−01 TCGA−AA−3543−01 TCGA−AA−3522−01 TCGA−A6−5666−01 TCGA−A6−4105−01 TCGA−A6−3808−01 TCGA−G5−6235−01 TCGA−G4−6626−01 TCGA−G4−6321−01 TCGA−G4−6310−01 TCGA−F5−6464−01 TCGA−F4−6703−01 TCGA−F4−6460−01 TCGA−EI−6510−01 TCGA−DM−A1D9−01 TCGA−DC−6158−01 TCGA−D5−6929−01 TCGA−D5−6924−01 TCGA−D5−6539−01 TCGA−D5−6534−01 TCGA−D5−5541−01 TCGA−D5−5540−01 TCGA−CM−6679−01 TCGA−CM−5344−01 TCGA−CM−5341−01 TCGA−CM−4752−01 TCGA−CA−6719−01 TCGA−AH−6644−01 TCGA−AG−A036−01 TCGA−AG−A025−01 TCGA−AG−A015−01 TCGA−AG−3742−01 TCGA−AG−3601−01 TCGA−AG−3594−01 TCGA−AF−2691−01 TCGA−AD−6888−01 TCGA−AA−A02W−01 TCGA−AA−A02K−01 TCGA−AA−A00U−01 TCGA−AA−3994−01 TCGA−AA−3989−01 TCGA−AA−3982−01 TCGA−AA−3854−01 TCGA−AA−3852−01 TCGA−AA−3831−01 TCGA−AA−3666−01 TCGA−AA−3562−01 TCGA−AA−3525−01 TCGA−A6−6651−01 TCGA−A6−6649−01 TCGA−A6−5660−01 TCGA−A6−2683−01 TCGA−A6−2677−01 TCGA−A6−2672−01 TCGA−A6−2671−01

Resolution Of D Loop Structures Through Holliday Junction Intermediates FDR = 1.9e−12%, FDR nod = 0.29% Presynaptic Phase Of Homologous DNA Pairing And Strand Exchange FDR = 2e−12%, FDR nod = 0.0018%

BRCA1

RFC5

MRE11A

RAD1

RMI1

RMI2

RFC4

MUS81

RBBP8

NBN

EXO1

GEN1

KAT5

RAD50 HUS1

BRCA1

ATM

BLM

BRCA2

ABL1

BLM

BARD1 HUS1

TOP3A

WRN

WRN

BRIP1

BRIP1

DNA2

BARD1

KAT5

RFC5

DNA2

RPA1

XRCC2

RPA3

ERCC1

ERCC4

RTEL1

XRCC3

EXO1

EXO1

MRE11A

NBN

RAD17

RAD52 NBN

KAT5

RAD51B

RAD1

MRE11A

RAD9A

RAD9B RBBP8

RAD51D

RAD51AP1

RFC2

RAD51C

RFC4

RMI1

RMI1

RMI2

RMI2

RPA2

RBBP8

TOP3A

PALB2

WRN

TOP3A

BARD1

BARD1

BRIP1

BRIP1

DNA2

RPA1

DNA2

SPIDR

RPA3

EME1

XRCC2

EXO1

CHEK1

KAT5

NBN

RAD51B

RAD17

RAD51D

RAD51B

XRCC2

RAD51D

RAD51C

MRE11A

RAD51AP1

RAD9A

RAD51C

RAD9B

RBBP8

RFC2

RMI2

RMI1

SLX1B

RPA2

XRCC3


wt wt

wt

ATRIP

known HCG mut PALB2

TOP3A

wt WRN ATRIP

wt TOPBP1

BRCA1 ATR

known HCG mut BLM RAD50

known HCG mut

SLX4 BLM

BRCA2 BRCA2

unknown CG mut ATM unknown CG mut ATM

unknown CG mut

ATR

unknown CG mut ATM PRKDC HERC2 RIF1 BRCA1 PAXIP1 BRE LIG4 RAD50 RNF168 BARD1 MDC1 MRE11A UIMC1 BRCC3 DCLRE1C FAM175A H2AFX HIST1H2BA HIST1H2BG HIST1H2BH HIST1H4E HIST1H4I HIST1H4L HIST4H4 KAT5 NBN NHEJ1 POLL RNF8 TDP1 BABAM1 HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BO HIST1H4A HIST1H4B HIST1H4D HIST1H4F HIST1H4H HIST1H4J HIST2H2BE HIST3H2BB HIST3H3 PIAS4 POLM TDP2 TP53BP1 UBE2N UBE2V2 WHSC1 XRCC4 XRCC5 XRCC6 unknown CG mut

SYNE1 ATR SYNE2 DIDO1 SYCP2 BRCA1 STAG1 RAD21 SMC1A STAG2 SYCP1 ACD HIST1H2BA HIST1H4I HIST1H4L HIST2H2AC POT1 SMC3 STAG3 UBE2I HIST1H2AB HIST1H2BF HIST1H2BG HIST1H2BH HIST1H4E HIST3H2BB HIST4H4 LMNB1 SMC1B SUN2 SYCE2 FKBP6 H2AFB1 H2AFX H2AFZ HIST1H2AC HIST1H2AE HIST1H2AJ HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BO HIST1H4A HIST1H4B HIST1H4D HIST1H4F HIST1H4H HIST1H4J HIST2H2AA4 HIST2H2BE HIST3H3 HSPA2 LMNA REC8 SUN1 SYCE1 SYCP3 TERF1 TERF2 TERF2IP TEX12 TINF2

TCGA−DY−A0XA−01 TCGA−A6−5659−01 TCGA−AA−A02J−01 TCGA−AA−3949−01 TCGA−AA−3667−01 TCGA−CM−5344−01 TCGA−D5−6927−01 TCGA−AG−3882−01 TCGA−AA−3525−01 TCGA−AA−3521−01 TCGA−DC−5869−01 TCGA−CK−6747−01 TCGA−AZ−6600−01 TCGA−AA−3845−01 TCGA−DT−5265−01 TCGA−D5−6922−01 TCGA−AA−3672−01 TCGA−AA−3812−01 TCGA−A6−2676−01 TCGA−AA−A01Q−01 TCGA−CM−6163−01 TCGA−AY−4071−01 TCGA−AA−3696−01 TCGA−AA−3815−01 TCGA−G4−6299−01 TCGA−AF−2687−01 TCGA−AA−A01P−01 TCGA−AA−3980−01 TCGA−CM−6674−01 TCGA−CK−5915−01 TCGA−AD−5900−01 TCGA−A6−3807−01 TCGA−AG−3732−01 TCGA−AA−3554−01 TCGA−AD−6895−01 TCGA−D5−6534−01 TCGA−AA−A00J−01 TCGA−CM−4744−01 TCGA−AY−5543−01 TCGA−A6−2672−01 TCGA−AA−3864−01 TCGA−CM−6161−01 TCGA−AA−3947−01 TCGA−CM−6166−01 TCGA−CA−6716−01 TCGA−AA−3854−01 TCGA−AA−3543−01 TCGA−CK−5916−01 TCGA−A6−3809−01 TCGA−DM−A1D6−01 TCGA−D5−5537−01 TCGA−CK−4948−01 TCGA−CI−6619−01 TCGA−CA−5797−01 TCGA−AA−A00E−01 TCGA−A6−6782−01 TCGA−CM−6162−01 TCGA−AA−3715−01 TCGA−DM−A0XD−01 TCGA−D5−6930−01 TCGA−CM−6678−01 TCGA−CM−5863−01 TCGA−AG−3601−01 TCGA−AD−6964−01 TCGA−AA−3712−01 TCGA−F4−6703−01 TCGA−F4−6460−01 TCGA−DY−A1DG−01 TCGA−DM−A1D9−01 TCGA−D5−6926−01 TCGA−CM−6172−01 TCGA−CI−6624−01 TCGA−CI−6622−01 TCGA−AG−A00C−01 TCGA−AF−5654−01 TCGA−AA−3562−01 TCGA−A6−6654−01 TCGA−A6−5656−01 TCGA−AG−A002−01 TCGA−CA−6717−01 TCGA−AA−A010−01 TCGA−AA−A00N−01 TCGA−CM−5861−01 TCGA−AZ−4315−01 TCGA−AA−3984−01 TCGA−AA−3977−01 TCGA−AA−3510−01 TCGA−G4−6628−01 TCGA−F4−6570−01 TCGA−CM−4743−01 TCGA−CK−6746−01 TCGA−AG−3892−01 TCGA−AA−3663−01 TCGA−AA−3496−01 TCGA−A6−6780−01 TCGA−A6−5665−01 TCGA−G4−6588−01 TCGA−CM−6171−01 TCGA−CA−6718−01 TCGA−AZ−6598−01 TCGA−AA−3713−01 TCGA−G4−6307−01 TCGA−D5−6540−01 TCGA−CM−6677−01 TCGA−AZ−6601−01 TCGA−AZ−6599−01 TCGA−AD−6889−01 TCGA−AA−3518−01 TCGA−A6−6781−01 TCGA−A6−5661−01 TCGA−G4−6309−01 TCGA−F4−6856−01 TCGA−EI−6507−01 TCGA−CM−5862−01 TCGA−CM−4752−01 TCGA−AY−6197−01 TCGA−AA−A022−01 TCGA−AA−3966−01 TCGA−AA−3710−01 TCGA−AA−3492−01 TCGA−A6−6653−01 TCGA−G4−6586−01 TCGA−G4−6317−01 TCGA−F5−6813−01 TCGA−EI−6508−01 TCGA−EI−6506−01 TCGA−EF−5830−01 TCGA−DY−A1H8−01 TCGA−DY−A1DF−01 TCGA−DY−A1DC−01 TCGA−DM−A28F−01 TCGA−DM−A0XF−01 TCGA−DC−6155−01 TCGA−D5−6929−01 TCGA−D5−6928−01 TCGA−D5−6923−01 TCGA−D5−6536−01 TCGA−D5−6533−01 TCGA−CM−6679−01 TCGA−CM−5868−01 TCGA−CM−5864−01 TCGA−CK−6751−01 TCGA−CK−5913−01 TCGA−CK−4952−01 TCGA−CK−4947−01 TCGA−CA−6715−01 TCGA−AU−6004−01 TCGA−AH−6643−01 TCGA−AH−6544−01 TCGA−AG−3885−01 TCGA−AA−A01R−01 TCGA−AA−3950−01 TCGA−AA−3819−01 TCGA−AA−3697−01 TCGA−AA−3664−01 TCGA−AA−3662−01 TCGA−AA−3660−01 TCGA−AA−3527−01 TCGA−A6−6141−01 TCGA−A6−4105−01 TCGA−G5−6641−01 TCGA−G5−6235−01 TCGA−G4−6321−01 TCGA−G4−6315−01 TCGA−G4−6306−01 TCGA−G4−6304−01 TCGA−G4−6293−01 TCGA−F5−6702−01 TCGA−F4−6854−01 TCGA−F4−6809−01 TCGA−F4−6808−01 TCGA−F4−6807−01 TCGA−DM−A28K−01 TCGA−DM−A28H−01 TCGA−DM−A28G−01 TCGA−DM−A28E−01 TCGA−DM−A28C−01 TCGA−DM−A1DB−01 TCGA−DM−A1D4−01 TCGA−DC−6683−01 TCGA−DC−5337−01 TCGA−D5−7000−01 TCGA−D5−6924−01 TCGA−D5−6920−01 TCGA−D5−6898−01 TCGA−D5−6541−01 TCGA−D5−6539−01 TCGA−D5−6538−01 TCGA−D5−6537−01 TCGA−D5−6535−01 TCGA−D5−6532−01 TCGA−D5−6529−01 TCGA−D5−5539−01 TCGA−D5−5538−01 TCGA−CM−6680−01 TCGA−CM−6170−01 TCGA−CM−6164−01 TCGA−CM−5860−01 TCGA−CM−5349−01 TCGA−CM−5348−01 TCGA−CL−5917−01 TCGA−CK−6748−01 TCGA−CK−5914−01 TCGA−CK−5912−01 TCGA−CA−6719−01 TCGA−AZ−6608−01 TCGA−AZ−6603−01 TCGA−AZ−5407−01 TCGA−AZ−5403−01 TCGA−AZ−4682−01 TCGA−AY−6196−01 TCGA−AU−3779−01 TCGA−AG−3742−01 TCGA−AG−3731−01 TCGA−AG−3727−01 TCGA−AG−3600−01 TCGA−AF−6655−01 TCGA−AF−2693−01 TCGA−AD−6963−01 TCGA−AD−6901−01 TCGA−AD−6899−01 TCGA−AD−6890−01 TCGA−AD−6548−01 TCGA−AA−A02Y−01 TCGA−AA−3861−01 TCGA−AA−3860−01 TCGA−AA−3811−01 TCGA−AA−3679−01 TCGA−AA−3678−01 TCGA−AA−3655−01 TCGA−AA−3555−01 TCGA−AA−3530−01 TCGA−AA−3522−01 TCGA−AA−3516−01 TCGA−AA−3502−01 TCGA−A6−5664−01 TCGA−A6−5660−01

TCGA−A6−6651−01 TCGA−AA−3955−01 TCGA−AG−3896−01 TCGA−DM−A0XD−01 TCGA−CM−5344−01 TCGA−F5−6571−01 TCGA−AA−3949−01 TCGA−AA−3511−01 TCGA−CM−6676−01 TCGA−AA−A004−01 TCGA−AA−3877−01 TCGA−CI−6621−01 TCGA−CA−6716−01 TCGA−AA−3947−01 TCGA−AA−3667−01 TCGA−AZ−6600−01 TCGA−AA−3845−01 TCGA−DT−5265−01 TCGA−D5−6922−01 TCGA−D5−6927−01 TCGA−A6−2678−01 TCGA−AY−4071−01 TCGA−AA−A01Q−01 TCGA−AA−3696−01 TCGA−CK−4950−01 TCGA−AF−6672−01 TCGA−A6−2671−01 TCGA−DY−A1DD−01 TCGA−DM−A1HA−01 TCGA−A6−5657−01 TCGA−AA−3672−01 TCGA−AG−3601−01 TCGA−AA−3812−01 TCGA−AA−3712−01 TCGA−AA−3815−01 TCGA−D5−6930−01 TCGA−AF−2687−01 TCGA−AA−A01P−01 TCGA−AA−3980−01 TCGA−DY−A0XA−01 TCGA−CM−6163−01 TCGA−CM−6161−01 TCGA−G4−6310−01 TCGA−AH−6644−01 TCGA−AA−A02K−01 TCGA−CK−5915−01 TCGA−AD−5900−01 TCGA−A6−3807−01 TCGA−CM−6674−01 TCGA−CM−5863−01 TCGA−AG−3732−01 TCGA−AA−3554−01 TCGA−CM−6162−01 TCGA−AD−6895−01 TCGA−D5−6534−01 TCGA−CM−6678−01 TCGA−CM−4744−01 TCGA−AY−5543−01 TCGA−AA−A00J−01 TCGA−A6−2672−01 TCGA−CK−5916−01 TCGA−AA−3715−01 TCGA−A6−3809−01 TCGA−DM−A1D6−01 TCGA−D5−5537−01 TCGA−CK−4948−01 TCGA−CI−6619−01 TCGA−CA−5797−01 TCGA−AA−A00E−01 TCGA−A6−6782−01 TCGA−AA−3864−01 TCGA−A6−2676−01 TCGA−G4−6299−01 TCGA−F4−6806−01 TCGA−DM−A285−01 TCGA−DC−6160−01 TCGA−D5−6931−01 TCGA−CM−6675−01 TCGA−CM−6172−01 TCGA−CM−6165−01 TCGA−CA−5255−01 TCGA−AY−4070−01 TCGA−AH−6549−01 TCGA−AA−3543−01 TCGA−A6−6648−01 TCGA−AG−A002−01 TCGA−CA−6717−01 TCGA−AA−A010−01 TCGA−AA−3510−01 TCGA−AZ−6598−01 TCGA−AA−A00N−01 TCGA−AA−3984−01 TCGA−AA−3977−01 TCGA−CK−6746−01 TCGA−CA−6718−01 TCGA−AZ−4315−01 TCGA−AG−3892−01 TCGA−AD−6889−01 TCGA−AA−3713−01 TCGA−AA−3663−01 TCGA−A6−5665−01 TCGA−G4−6628−01 TCGA−AY−6197−01 TCGA−AA−3496−01 TCGA−A6−6781−01 TCGA−G4−6588−01 TCGA−G4−6309−01 TCGA−F4−6856−01 TCGA−F4−6570−01 TCGA−CM−5861−01 TCGA−CM−4743−01 TCGA−AA−3492−01 TCGA−A6−5661−01 TCGA−G4−6317−01 TCGA−EF−5830−01 TCGA−D5−6540−01 TCGA−D5−6536−01 TCGA−CM−6171−01 TCGA−CK−4952−01 TCGA−AZ−6601−01 TCGA−AA−A022−01 TCGA−AA−3950−01 TCGA−A6−6780−01 TCGA−A6−6653−01 TCGA−D5−7000−01 TCGA−D5−6928−01 TCGA−CM−5862−01 TCGA−CM−5348−01 TCGA−CK−6751−01 TCGA−AU−6004−01 TCGA−AD−6901−01 TCGA−AA−3710−01 TCGA−AA−3518−01 TCGA−AA−3516−01 TCGA−A6−6141−01 TCGA−G4−6586−01 TCGA−G4−6321−01 TCGA−G4−6315−01 TCGA−G4−6307−01 TCGA−G4−6293−01 TCGA−F5−6813−01 TCGA−F4−6808−01 TCGA−EI−6508−01 TCGA−EI−6507−01 TCGA−EI−6506−01 TCGA−DY−A1H8−01 TCGA−DY−A1DF−01 TCGA−DM−A0XF−01 TCGA−DC−5337−01 TCGA−D5−6920−01 TCGA−D5−6539−01 TCGA−D5−6535−01 TCGA−D5−6532−01 TCGA−D5−5538−01 TCGA−CM−6677−01 TCGA−CM−6170−01 TCGA−CM−5864−01 TCGA−CL−5917−01 TCGA−CK−5912−01 TCGA−CK−4947−01 TCGA−AZ−6608−01 TCGA−AZ−6603−01 TCGA−AZ−6599−01 TCGA−AZ−5407−01 TCGA−AY−6196−01 TCGA−AH−6544−01 TCGA−AG−3885−01 TCGA−AA−A01R−01 TCGA−AA−3966−01 TCGA−AA−3811−01 TCGA−AA−3664−01 TCGA−AA−3527−01 TCGA−AA−3502−01 TCGA−G5−6641−01 TCGA−G5−6235−01 TCGA−G4−6306−01 TCGA−G4−6304−01 TCGA−F5−6702−01 TCGA−F4−6854−01 TCGA−F4−6809−01 TCGA−F4−6807−01 TCGA−DY−A1DC−01 TCGA−DM−A28K−01 TCGA−DM−A28H−01 TCGA−DM−A28G−01 TCGA−DM−A28F−01 TCGA−DM−A28E−01 TCGA−DM−A28C−01 TCGA−DM−A1DB−01 TCGA−DM−A1D4−01 TCGA−DC−6683−01 TCGA−DC−6155−01 TCGA−D5−6929−01 TCGA−D5−6924−01 TCGA−D5−6923−01 TCGA−D5−6898−01 TCGA−D5−6541−01 TCGA−D5−6538−01 TCGA−D5−6537−01 TCGA−D5−6533−01 TCGA−D5−6529−01 TCGA−D5−5539−01 TCGA−CM−6680−01 TCGA−CM−6679−01 TCGA−CM−6164−01 TCGA−CM−5868−01 TCGA−CM−5860−01 TCGA−CM−5349−01 TCGA−CM−4752−01 TCGA−CK−6748−01 TCGA−CK−5914−01 TCGA−CK−5913−01 TCGA−CA−6719−01 TCGA−CA−6715−01 TCGA−AZ−5403−01 TCGA−AZ−4682−01 TCGA−AU−3779−01 TCGA−AH−6643−01 TCGA−AG−3742−01 TCGA−AG−3731−01 TCGA−AG−3727−01 TCGA−AG−3600−01 TCGA−AF−6655−01 TCGA−AF−2693−01 TCGA−AD−6963−01 TCGA−AD−6899−01 TCGA−AD−6890−01 TCGA−AD−6548−01 TCGA−AA−A02Y−01 TCGA−AA−3861−01 TCGA−AA−3860−01 TCGA−AA−3819−01 TCGA−AA−3697−01 TCGA−AA−3679−01 TCGA−AA−3678−01 TCGA−AA−3662−01 TCGA−AA−3660−01 TCGA−AA−3655−01 TCGA−AA−3555−01 TCGA−AA−3530−01 TCGA−AA−3522−01 TCGA−A6−5664−01 TCGA−A6−5660−01 TCGA−A6−4105−01

Nonhomologous End Joining (NHEJ) FDR = 1.5e−07%, FDR nod = 1.3% Meiotic Synapsis FDR = 7.1e−09%, FDR nod = 2.6e−10%

RAD50

wt TOPBP1

BRCA1

known HCG mut RAD50

unknown CG mut

Homologous DNA Pairing And Strand Exchange Resolution Of D Loop Structures Through Synthesis Dependent Strand Annealing (SDSA) FDR = 1.9e−12%, FDR nod = 0.014%

HDR Through Single Strand Annealing (SSA) FDR = 1.9e−12%, FDR nod = 0.028%

TCGA−AG−3882−01 TCGA−AA−3521−01 TCGA−A6−5659−01 TCGA−AA−A02J−01 TCGA−AA−3949−01 TCGA−AA−3667−01 TCGA−CM−5344−01 TCGA−AA−3877−01 TCGA−AA−3930−01 TCGA−AA−3666−01 TCGA−DY−A0XA−01 TCGA−D5−6927−01 TCGA−AA−3845−01 TCGA−AZ−6600−01 TCGA−DT−5265−01 TCGA−D5−6922−01 TCGA−AA−3672−01 TCGA−AA−3812−01 TCGA−A6−2676−01 TCGA−AA−A01Q−01 TCGA−CM−6163−01 TCGA−AY−4071−01 TCGA−AA−3696−01 TCGA−CK−5915−01 TCGA−AD−5900−01 TCGA−A6−3807−01 TCGA−AA−3554−01 TCGA−AA−3815−01 TCGA−G4−6299−01 TCGA−AF−2687−01 TCGA−AA−A01P−01 TCGA−AA−3980−01 TCGA−CM−6161−01 TCGA−CM−6166−01 TCGA−CA−6716−01 TCGA−AA−3854−01 TCGA−AA−3543−01 TCGA−AD−6895−01 TCGA−D5−6534−01 TCGA−AA−A00J−01 TCGA−CM−4744−01 TCGA−A6−2672−01 TCGA−AA−3864−01 TCGA−CM−6674−01 TCGA−AA−3947−01 TCGA−AY−5543−01 TCGA−AG−3732−01 TCGA−AA−3525−01 TCGA−G4−6310−01 TCGA−DC−6160−01 TCGA−AA−3821−01 TCGA−CK−5916−01 TCGA−A6−3809−01 TCGA−DM−A1D6−01 TCGA−D5−5537−01 TCGA−CK−4948−01 TCGA−CI−6619−01 TCGA−CA−5797−01 TCGA−AA−A00E−01 TCGA−A6−6782−01 TCGA−CM−6162−01 TCGA−AA−3715−01 TCGA−AD−6964−01 TCGA−DM−A0XD−01 TCGA−D5−6930−01 TCGA−CM−6678−01 TCGA−CM−5863−01 TCGA−AG−3601−01 TCGA−AA−3712−01 TCGA−F4−6703−01 TCGA−F4−6460−01 TCGA−DY−A1DG−01 TCGA−DM−A1D9−01 TCGA−D5−6926−01 TCGA−CM−6172−01 TCGA−CI−6624−01 TCGA−CI−6622−01 TCGA−AG−A00C−01 TCGA−AF−5654−01 TCGA−AA−3562−01 TCGA−A6−6654−01 TCGA−A6−5656−01 TCGA−CA−6717−01 TCGA−AG−A002−01 TCGA−AA−A010−01 TCGA−AA−3977−01 TCGA−AA−A00N−01 TCGA−AA−3984−01 TCGA−AZ−4315−01 TCGA−A6−5665−01 TCGA−CM−5861−01 TCGA−CK−6746−01 TCGA−AG−3892−01 TCGA−AA−3510−01 TCGA−G4−6628−01 TCGA−F4−6570−01 TCGA−CM−4743−01 TCGA−CA−6718−01 TCGA−AA−3663−01 TCGA−AA−3496−01 TCGA−A6−6780−01 TCGA−G4−6588−01 TCGA−D5−6540−01 TCGA−CM−6171−01 TCGA−AZ−6598−01 TCGA−AD−6889−01 TCGA−AA−3713−01 TCGA−G4−6307−01 TCGA−CM−6677−01 TCGA−AZ−6601−01 TCGA−AZ−6599−01 TCGA−AY−6197−01 TCGA−AA−3518−01 TCGA−A6−6781−01 TCGA−A6−6653−01 TCGA−A6−5661−01 TCGA−G4−6309−01 TCGA−G4−6306−01 TCGA−F4−6856−01 TCGA−EI−6507−01 TCGA−D5−6928−01 TCGA−CM−5864−01 TCGA−CM−5862−01 TCGA−CM−4752−01 TCGA−AA−A022−01 TCGA−AA−A01R−01 TCGA−AA−3966−01 TCGA−AA−3950−01 TCGA−AA−3710−01 TCGA−AA−3492−01 TCGA−G4−6586−01 TCGA−G4−6317−01 TCGA−F5−6813−01 TCGA−F4−6809−01 TCGA−EI−6508−01 TCGA−EI−6506−01 TCGA−EF−5830−01 TCGA−DY−A1H8−01 TCGA−DY−A1DF−01 TCGA−DM−A0XF−01 TCGA−DC−6155−01 TCGA−D5−6929−01 TCGA−D5−6923−01 TCGA−D5−6537−01 TCGA−D5−6536−01 TCGA−D5−6533−01 TCGA−CM−6679−01 TCGA−CM−5868−01 TCGA−CK−6751−01 TCGA−CK−5913−01 TCGA−CK−4952−01 TCGA−CK−4947−01 TCGA−CA−6715−01 TCGA−AU−6004−01 TCGA−AU−3779−01 TCGA−AH−6643−01 TCGA−AH−6544−01 TCGA−AG−3885−01 TCGA−AG−3731−01 TCGA−AD−6901−01 TCGA−AA−3819−01 TCGA−AA−3811−01 TCGA−AA−3697−01 TCGA−AA−3664−01 TCGA−AA−3662−01 TCGA−AA−3660−01 TCGA−AA−3527−01 TCGA−A6−6141−01 TCGA−A6−5660−01 TCGA−A6−4105−01 TCGA−G5−6641−01 TCGA−G5−6235−01 TCGA−G4−6321−01 TCGA−G4−6315−01 TCGA−G4−6304−01 TCGA−G4−6293−01 TCGA−F5−6702−01 TCGA−F4−6854−01 TCGA−F4−6808−01 TCGA−F4−6807−01 TCGA−DY−A1DC−01 TCGA−DM−A28K−01 TCGA−DM−A28H−01 TCGA−DM−A28G−01 TCGA−DM−A28F−01 TCGA−DM−A28E−01 TCGA−DM−A28C−01 TCGA−DM−A1DB−01 TCGA−DM−A1D4−01 TCGA−DC−6683−01 TCGA−DC−5337−01 TCGA−D5−7000−01 TCGA−D5−6924−01 TCGA−D5−6920−01 TCGA−D5−6898−01 TCGA−D5−6541−01 TCGA−D5−6539−01 TCGA−D5−6538−01 TCGA−D5−6535−01 TCGA−D5−6532−01 TCGA−D5−6529−01 TCGA−D5−5539−01 TCGA−D5−5538−01 TCGA−CM−6680−01 TCGA−CM−6170−01 TCGA−CM−6164−01 TCGA−CM−5860−01 TCGA−CM−5349−01 TCGA−CM−5348−01 TCGA−CL−5917−01 TCGA−CK−6748−01 TCGA−CK−5914−01 TCGA−CK−5912−01 TCGA−CA−6719−01 TCGA−AZ−6608−01 TCGA−AZ−6603−01 TCGA−AZ−5407−01 TCGA−AZ−5403−01 TCGA−AZ−4682−01 TCGA−AY−6196−01 TCGA−AG−3742−01 TCGA−AG−3727−01 TCGA−AG−3600−01 TCGA−AF−6655−01 TCGA−AF−2693−01 TCGA−AD−6963−01 TCGA−AD−6899−01 TCGA−AD−6890−01 TCGA−AD−6548−01 TCGA−AA−A02Y−01 TCGA−AA−3861−01 TCGA−AA−3860−01 TCGA−AA−3679−01 TCGA−AA−3678−01 TCGA−AA−3655−01 TCGA−AA−3555−01 TCGA−AA−3530−01 TCGA−AA−3522−01 TCGA−AA−3516−01 TCGA−AA−3502−01 TCGA−A6−5664−01

TCGA−A6−6651−01 TCGA−DY−A0XA−01 TCGA−A6−5659−01 TCGA−AA−A02J−01 TCGA−AG−3896−01 TCGA−AA−3949−01 TCGA−CM−6161−01 TCGA−CM−5344−01 TCGA−EI−6510−01 TCGA−AA−3525−01 TCGA−AA−3521−01 TCGA−AA−3511−01 TCGA−CM−6676−01 TCGA−AA−A004−01 TCGA−AA−3877−01 TCGA−CI−6621−01 TCGA−CA−6716−01 TCGA−AA−3947−01 TCGA−AA−3667−01 TCGA−AZ−6600−01 TCGA−AA−3845−01 TCGA−DT−5265−01 TCGA−D5−6922−01 TCGA−AA−3672−01 TCGA−AA−3812−01 TCGA−D5−6927−01 TCGA−A6−2678−01 TCGA−CK−4950−01 TCGA−AF−6672−01 TCGA−A6−2671−01 TCGA−DY−A1DD−01 TCGA−DM−A1HA−01 TCGA−A6−5657−01 TCGA−AA−A01Q−01 TCGA−CM−6163−01 TCGA−AY−4071−01 TCGA−AA−3696−01 TCGA−AA−3815−01 TCGA−AF−2687−01 TCGA−AA−A01P−01 TCGA−AA−3980−01 TCGA−CM−6674−01 TCGA−CK−5915−01 TCGA−AD−5900−01 TCGA−A6−3807−01 TCGA−AG−3732−01 TCGA−AA−3554−01 TCGA−AD−6895−01 TCGA−D5−6534−01 TCGA−AA−A00J−01 TCGA−CM−4744−01 TCGA−AY−5543−01 TCGA−A6−2672−01 TCGA−CK−5916−01 TCGA−A6−3809−01 TCGA−DM−A1D6−01 TCGA−D5−5537−01 TCGA−CK−4948−01 TCGA−CI−6619−01 TCGA−CA−5797−01 TCGA−AA−A00E−01 TCGA−A6−6782−01 TCGA−AA−3864−01 TCGA−G4−6299−01 TCGA−A6−2676−01 TCGA−F4−6806−01 TCGA−DM−A285−01 TCGA−DC−6160−01 TCGA−D5−6931−01 TCGA−CM−6675−01 TCGA−CM−6165−01 TCGA−CA−5255−01 TCGA−AY−4070−01 TCGA−AH−6549−01 TCGA−AA−3543−01 TCGA−A6−6648−01 TCGA−CM−6162−01 TCGA−AA−3715−01 TCGA−AD−6964−01 TCGA−DM−A0XD−01 TCGA−D5−6930−01 TCGA−CM−6678−01 TCGA−CM−6172−01 TCGA−CM−5863−01 TCGA−AG−3601−01 TCGA−AA−3712−01 TCGA−A6−6654−01 TCGA−F4−6703−01 TCGA−F4−6460−01 TCGA−DY−A1DG−01 TCGA−DM−A1D9−01 TCGA−D5−6926−01 TCGA−CI−6624−01 TCGA−CI−6622−01 TCGA−AG−A00C−01 TCGA−AF−5654−01 TCGA−AA−3562−01 TCGA−A6−5656−01 TCGA−AG−A002−01 TCGA−CA−6717−01 TCGA−AA−A010−01 TCGA−AA−A00N−01 TCGA−AA−3984−01 TCGA−AA−3510−01 TCGA−CK−6746−01 TCGA−AZ−6598−01 TCGA−A6−5665−01 TCGA−CA−6718−01 TCGA−AZ−4315−01 TCGA−AA−3977−01 TCGA−AA−3713−01 TCGA−AA−3496−01 TCGA−CM−5861−01 TCGA−AG−3892−01 TCGA−AA−3663−01 TCGA−G4−6628−01 TCGA−F4−6570−01 TCGA−CM−4743−01 TCGA−A6−6781−01 TCGA−G4−6309−01 TCGA−AY−6197−01 TCGA−AD−6889−01 TCGA−A6−6780−01 TCGA−G4−6588−01 TCGA−G4−6317−01 TCGA−G4−6307−01 TCGA−F4−6856−01 TCGA−D5−6540−01 TCGA−D5−6536−01 TCGA−CM−6171−01 TCGA−AZ−6601−01 TCGA−AU−6004−01 TCGA−AA−3950−01 TCGA−AA−3518−01 TCGA−AA−3492−01 TCGA−A6−6653−01 TCGA−EI−6507−01 TCGA−EF−5830−01 TCGA−DM−A0XF−01 TCGA−D5−6928−01 TCGA−CM−6677−01 TCGA−CM−5862−01 TCGA−CM−5348−01 TCGA−CK−6751−01 TCGA−CK−5913−01 TCGA−CK−4952−01 TCGA−AZ−6599−01 TCGA−AA−A022−01 TCGA−AA−3966−01 TCGA−AA−3710−01 TCGA−AA−3664−01 TCGA−A6−6141−01 TCGA−A6−5661−01 TCGA−G4−6586−01 TCGA−G4−6315−01 TCGA−G4−6293−01 TCGA−F5−6813−01 TCGA−F4−6808−01 TCGA−EI−6508−01 TCGA−EI−6506−01 TCGA−DY−A1H8−01 TCGA−DY−A1DF−01 TCGA−DC−6155−01 TCGA−DC−5337−01 TCGA−D5−6929−01 TCGA−D5−6923−01 TCGA−D5−6920−01 TCGA−D5−6535−01 TCGA−D5−6533−01 TCGA−D5−5538−01 TCGA−CM−6679−01 TCGA−CM−6170−01 TCGA−CM−5868−01 TCGA−CM−5864−01 TCGA−CM−4752−01 TCGA−CL−5917−01 TCGA−CK−5912−01 TCGA−CK−4947−01 TCGA−CA−6715−01 TCGA−AZ−6608−01 TCGA−AZ−6603−01 TCGA−AH−6643−01 TCGA−AH−6544−01 TCGA−AG−3885−01 TCGA−AD−6901−01 TCGA−AA−A01R−01 TCGA−AA−3811−01 TCGA−AA−3697−01 TCGA−AA−3662−01 TCGA−AA−3527−01 TCGA−AA−3502−01 TCGA−G5−6641−01 TCGA−G5−6235−01 TCGA−G4−6321−01 TCGA−G4−6306−01 TCGA−G4−6304−01 TCGA−F5−6702−01 TCGA−F4−6854−01 TCGA−F4−6809−01 TCGA−F4−6807−01 TCGA−DY−A1DC−01 TCGA−DM−A28K−01 TCGA−DM−A28H−01 TCGA−DM−A28G−01 TCGA−DM−A28F−01 TCGA−DM−A28E−01 TCGA−DM−A28C−01 TCGA−DM−A1DB−01 TCGA−DM−A1D4−01 TCGA−DC−6683−01 TCGA−D5−7000−01 TCGA−D5−6924−01 TCGA−D5−6898−01 TCGA−D5−6541−01 TCGA−D5−6539−01 TCGA−D5−6538−01 TCGA−D5−6537−01 TCGA−D5−6532−01 TCGA−D5−6529−01 TCGA−D5−5539−01 TCGA−CM−6680−01 TCGA−CM−6164−01 TCGA−CM−5860−01 TCGA−CM−5349−01 TCGA−CK−6748−01 TCGA−CK−5914−01 TCGA−CA−6719−01 TCGA−AZ−5407−01 TCGA−AZ−5403−01 TCGA−AZ−4682−01 TCGA−AY−6196−01 TCGA−AU−3779−01 TCGA−AG−3742−01 TCGA−AG−3731−01 TCGA−AG−3727−01 TCGA−AG−3600−01 TCGA−AF−6655−01 TCGA−AF−2693−01 TCGA−AD−6963−01 TCGA−AD−6899−01 TCGA−AD−6890−01 TCGA−AD−6548−01 TCGA−AA−A02Y−01 TCGA−AA−3861−01 TCGA−AA−3860−01 TCGA−AA−3819−01 TCGA−AA−3679−01 TCGA−AA−3678−01 TCGA−AA−3660−01 TCGA−AA−3655−01 TCGA−AA−3555−01 TCGA−AA−3530−01 TCGA−AA−3522−01 TCGA−AA−3516−01 TCGA−A6−5664−01 TCGA−A6−5660−01 TCGA−A6−4105−01

HIF 2 Alpha Transcription Factor Network FDR = 2e−04%, FDR nod = 0.2%

TCGA−F4−6809−01 TCGA−A6−2671−01 TCGA−AA−A01P−01 TCGA−AA−A02K−01 TCGA−F4−6856−01 TCGA−AA−A00L−01 TCGA−AA−3492−01 TCGA−CM−6674−01 TCGA−AA−3833−01 TCGA−AA−3525−01 TCGA−DT−5265−01 TCGA−AA−3664−01 TCGA−D5−6928−01 TCGA−A6−5661−01 TCGA−AG−3598−01 TCGA−AA−3975−01 TCGA−AG−3583−01 TCGA−AA−3710−01 TCGA−AA−A00A−01 TCGA−CL−5918−01 TCGA−AG−3892−01 TCGA−DM−A28K−01 TCGA−CM−6679−01 TCGA−AG−3575−01 TCGA−AA−3712−01 TCGA−CM−4746−01 TCGA−DM−A0XD−01 TCGA−AA−3531−01 TCGA−A6−6142−01 TCGA−AZ−6598−01 TCGA−AD−6895−01 TCGA−DM−A28F−01 TCGA−DM−A1D9−01 TCGA−D5−6932−01 TCGA−CK−5915−01 TCGA−AA−3489−01 TCGA−AA−3977−01 TCGA−CA−6718−01 TCGA−AA−3949−01 TCGA−F4−6703−01 TCGA−CM−5860−01 TCGA−AF−5654−01 TCGA−AF−4110−01 TCGA−AA−3950−01 TCGA−F4−6854−01 TCGA−DM−A28E−01 TCGA−CA−5797−01 TCGA−AG−3878−01 TCGA−AF−6136−01 TCGA−AA−A01Q−01 TCGA−AA−A00N−01 TCGA−CK−5913−01 TCGA−AA−A00J−01 TCGA−A6−6780−01 TCGA−D5−6931−01 TCGA−D5−6539−01 TCGA−CM−4752−01 TCGA−CI−6619−01 TCGA−AD−6889−01 TCGA−AA−A00R−01 TCGA−AA−3555−01 TCGA−AA−3527−01 TCGA−A6−6141−01 TCGA−G5−6235−01 TCGA−G4−6323−01 TCGA−F5−6813−01 TCGA−DM−A1D0−01 TCGA−DC−6682−01 TCGA−CM−6162−01 TCGA−CM−5868−01 TCGA−CA−5796−01 TCGA−AY−6386−01 TCGA−AF−2687−01 TCGA−AA−A01G−01 TCGA−AA−3554−01 TCGA−A6−6781−01 TCGA−A6−5659−01 TCGA−CA−6717−01 TCGA−AZ−4315−01 TCGA−AA−A010−01 TCGA−AA−3864−01 TCGA−AA−3815−01 TCGA−AA−3672−01 TCGA−G4−6588−01 TCGA−EI−6507−01 TCGA−AZ−6601−01 TCGA−AA−3984−01 TCGA−AA−3715−01 TCGA−G4−6586−01 TCGA−CM−4743−01 TCGA−AU−3779−01 TCGA−AA−A022−01 TCGA−AA−3966−01 TCGA−AA−3877−01 TCGA−DM−A1DA−01 TCGA−AG−A02N−01 TCGA−AA−A00E−01 TCGA−AA−3947−01 TCGA−AA−3811−01 TCGA−AA−3662−01 TCGA−G4−6625−01 TCGA−G4−6307−01 TCGA−G4−6304−01 TCGA−F4−6808−01 TCGA−F4−6460−01 TCGA−DM−A28H−01 TCGA−DM−A1HA−01 TCGA−DM−A1D8−01 TCGA−DM−A1D7−01 TCGA−D5−5538−01 TCGA−D5−5537−01 TCGA−CM−6680−01 TCGA−CI−6620−01 TCGA−AH−6643−01 TCGA−AH−6544−01 TCGA−AG−3731−01 TCGA−AD−6963−01 TCGA−AA−A029−01 TCGA−AA−3973−01 TCGA−AA−3818−01 TCGA−AA−3713−01 TCGA−AA−3518−01 TCGA−AA−3516−01 TCGA−AA−3510−01 TCGA−AG−A002−01 TCGA−G4−6628−01 TCGA−AY−6197−01 TCGA−D5−6540−01 TCGA−AD−5900−01 TCGA−DY−A0XA−01 TCGA−CK−6746−01 TCGA−AU−6004−01 TCGA−AD−6964−01 TCGA−AA−3663−01 TCGA−G4−6293−01 TCGA−EI−6510−01 TCGA−CM−6171−01 TCGA−CM−6168−01 TCGA−CI−6624−01 TCGA−AZ−6599−01 TCGA−AG−3732−01 TCGA−AD−6965−01 TCGA−A6−6653−01 TCGA−A6−5665−01 TCGA−G5−6641−01 TCGA−G4−6321−01 TCGA−G4−6315−01 TCGA−G4−6310−01 TCGA−F5−6812−01 TCGA−F4−6570−01 TCGA−EF−5830−01 TCGA−DY−A1DD−01 TCGA−D5−6929−01 TCGA−D5−6923−01 TCGA−D5−6535−01 TCGA−D5−5540−01 TCGA−CM−6164−01 TCGA−CM−6161−01 TCGA−CM−5862−01 TCGA−CM−5861−01 TCGA−CM−5349−01 TCGA−CM−5344−01 TCGA−CK−4948−01 TCGA−AZ−6605−01 TCGA−AZ−5403−01 TCGA−AY−5543−01 TCGA−AH−6549−01 TCGA−AA−3697−01 TCGA−AA−3655−01 TCGA−A6−5662−01 TCGA−A6−4105−01 TCGA−G4−6626−01 TCGA−F5−6811−01 TCGA−F4−6855−01 TCGA−F4−6807−01 TCGA−DM−A28G−01 TCGA−DM−A1D4−01 TCGA−DC−6683−01 TCGA−DC−6681−01 TCGA−DC−5337−01 TCGA−D5−6922−01 TCGA−D5−6537−01 TCGA−D5−6536−01 TCGA−D5−6533−01 TCGA−D5−6532−01 TCGA−CM−6678−01 TCGA−CM−6676−01 TCGA−CM−6170−01 TCGA−CM−6169−01 TCGA−CM−6163−01 TCGA−CM−5864−01 TCGA−CM−5348−01 TCGA−CA−5255−01 TCGA−AZ−6608−01 TCGA−AZ−6603−01 TCGA−AF−6672−01 TCGA−AF−6655−01 TCGA−AF−2693−01 TCGA−AA−3968−01 TCGA−AA−3861−01 TCGA−A6−5666−01 TCGA−A6−5657−01

TCGA−AA−3663−01 TCGA−AA−3979−01 TCGA−DY−A1H8−01 TCGA−AA−3811−01 TCGA−G4−6586−01 TCGA−F4−6807−01 TCGA−F4−6570−01 TCGA−DM−A28G−01 TCGA−D5−6932−01 TCGA−D5−6928−01 TCGA−D5−6541−01 TCGA−CM−6166−01 TCGA−CM−5860−01 TCGA−CM−5344−01 TCGA−CK−6748−01 TCGA−CA−6718−01 TCGA−CA−6717−01 TCGA−CA−6716−01 TCGA−AZ−6599−01 TCGA−AZ−6598−01 TCGA−AZ−4315−01 TCGA−AD−6965−01 TCGA−AA−A029−01 TCGA−AA−A00O−01 TCGA−AA−3984−01 TCGA−AA−3662−01 TCGA−AA−3655−01 TCGA−AA−3510−01 TCGA−A6−5665−01 TCGA−A6−3808−01

Hypoxic And Oxygen Homeostasis Regulation Of HIF 1 Alpha FDR = 1.9e−12%, FDR nod = 0.018% Hypoxia Response Via HIF Activation FDR = 1.9e−12%, FDR nod = 3.7e−09%

ELK1 LHCGR

SIRT1 CGB3

TCGA−AG−3887−01 TCGA−AA−3518−01 TCGA−AA−3510−01 TCGA−AA−A01P−01 TCGA−AA−3527−01 TCGA−AA−3710−01 TCGA−A6−6781−01 TCGA−AA−3947−01 TCGA−AA−3525−01 TCGA−AA−A00A−01 TCGA−AA−3672−01 TCGA−CM−6674−01 TCGA−AA−A02K−01 TCGA−AA−3950−01 TCGA−A6−3809−01 TCGA−G4−6588−01 TCGA−AA−A022−01 TCGA−AZ−6606−01 TCGA−AA−A00N−01 TCGA−AA−3877−01 TCGA−AZ−4315−01 TCGA−D5−6928−01 TCGA−AD−6889−01 TCGA−AA−A01Q−01 TCGA−AA−3966−01 TCGA−AA−3555−01 TCGA−AG−A002−01 TCGA−A6−6653−01 TCGA−CM−5861−01 TCGA−CK−6746−01 TCGA−AD−6964−01 TCGA−G5−6641−01 TCGA−F5−6811−01 TCGA−F4−6855−01 TCGA−F4−6570−01 TCGA−DM−A28G−01 TCGA−DC−6681−01 TCGA−D5−6537−01 TCGA−D5−6536−01 TCGA−CM−6678−01 TCGA−CM−6170−01 TCGA−CM−5344−01 TCGA−CA−5255−01 TCGA−AZ−6603−01 TCGA−AH−6549−01 TCGA−AA−3968−01 TCGA−AA−3861−01 TCGA−A6−5666−01 TCGA−A6−5657−01 TCGA−G4−6628−01 TCGA−CA−6718−01 TCGA−AA−A010−01 TCGA−AZ−6598−01 TCGA−AU−6004−01 TCGA−AA−3663−01 TCGA−A6−4105−01 TCGA−G4−6310−01 TCGA−G4−6293−01 TCGA−D5−6535−01 TCGA−D5−6532−01 TCGA−D5−5540−01 TCGA−CM−6171−01 TCGA−CM−5349−01 TCGA−CI−6624−01 TCGA−CA−6717−01 TCGA−AZ−6605−01 TCGA−AY−6197−01 TCGA−AA−3815−01 TCGA−G4−6626−01 TCGA−G4−6321−01 TCGA−G4−6315−01 TCGA−F5−6812−01 TCGA−F4−6807−01 TCGA−EI−6510−01 TCGA−EF−5830−01 TCGA−DY−A1DD−01 TCGA−DY−A1DC−01 TCGA−DY−A0XA−01 TCGA−DM−A1D9−01 TCGA−DM−A1D4−01 TCGA−DC−6683−01 TCGA−DC−5337−01 TCGA−D5−6929−01 TCGA−D5−6923−01 TCGA−D5−6922−01 TCGA−D5−6540−01 TCGA−D5−6538−01 TCGA−D5−6533−01 TCGA−CM−6676−01 TCGA−CM−6169−01 TCGA−CM−6168−01 TCGA−CM−6164−01 TCGA−CM−6163−01 TCGA−CM−6161−01 TCGA−CM−5864−01 TCGA−CM−5862−01 TCGA−CM−5348−01 TCGA−CM−4752−01 TCGA−CM−4746−01 TCGA−CM−4743−01 TCGA−CK−5916−01 TCGA−CK−4948−01 TCGA−CI−6621−01 TCGA−AZ−6608−01 TCGA−AZ−6601−01 TCGA−AZ−6599−01 TCGA−AZ−5403−01 TCGA−AY−5543−01 TCGA−AG−3902−01 TCGA−AG−3732−01 TCGA−AF−6672−01 TCGA−AF−6655−01 TCGA−AF−6136−01 TCGA−AF−2693−01 TCGA−AD−6965−01 TCGA−AD−6901−01 TCGA−AD−5900−01 TCGA−AA−A00L−01 TCGA−AA−A00E−01 TCGA−AA−3949−01 TCGA−AA−3697−01 TCGA−AA−3660−01 TCGA−AA−3655−01 TCGA−A6−5665−01 TCGA−A6−5662−01 TCGA−A6−5659−01 TCGA−A6−2676−01 TCGA−G5−6235−01 TCGA−G4−6625−01 TCGA−G4−6586−01 TCGA−G4−6323−01 TCGA−G4−6317−01 TCGA−G4−6307−01 TCGA−G4−6306−01 TCGA−G4−6304−01 TCGA−G4−6303−01 TCGA−G4−6299−01 TCGA−F5−6813−01 TCGA−F5−6702−01 TCGA−F5−6571−01 TCGA−F5−6464−01 TCGA−F4−6856−01 TCGA−F4−6854−01 TCGA−F4−6808−01 TCGA−F4−6806−01 TCGA−F4−6805−01 TCGA−F4−6704−01 TCGA−F4−6703−01 TCGA−F4−6460−01 TCGA−F4−6459−01 TCGA−EI−6508−01 TCGA−EI−6507−01 TCGA−EI−6506−01 TCGA−DY−A1DG−01 TCGA−DY−A1DF−01 TCGA−DT−5265−01 TCGA−DM−A28K−01 TCGA−DM−A28H−01 TCGA−DM−A28F−01 TCGA−DM−A28E−01 TCGA−DM−A285−01 TCGA−DM−A1HA−01 TCGA−DM−A1DB−01 TCGA−DM−A1DA−01 TCGA−DM−A1D8−01 TCGA−DM−A1D7−01 TCGA−DM−A1D6−01 TCGA−DM−A1D0−01 TCGA−DM−A0XF−01 TCGA−DM−A0XD−01 TCGA−DC−6682−01 TCGA−DC−6158−01 TCGA−DC−6157−01 TCGA−DC−6155−01 TCGA−DC−5869−01 TCGA−D5−6932−01 TCGA−D5−6931−01 TCGA−D5−6930−01 TCGA−D5−6927−01 TCGA−D5−6926−01 TCGA−D5−6924−01 TCGA−D5−6920−01 TCGA−D5−6898−01 TCGA−D5−6541−01 TCGA−D5−6539−01 TCGA−D5−5541−01 TCGA−D5−5538−01 TCGA−CM−6679−01 TCGA−CM−6677−01 TCGA−CM−6675−01 TCGA−CM−6172−01 TCGA−CM−6166−01 TCGA−CM−6165−01 TCGA−CM−6162−01 TCGA−CM−5868−01 TCGA−CM−5860−01 TCGA−CM−5341−01 TCGA−CM−4744−01 TCGA−CL−5918−01 TCGA−CL−5917−01 TCGA−CK−5914−01 TCGA−CK−4952−01 TCGA−CK−4950−01 TCGA−CK−4947−01 TCGA−CI−6622−01 TCGA−CI−6620−01 TCGA−CI−6619−01 TCGA−CA−6719−01 TCGA−CA−6716−01 TCGA−CA−5797−01 TCGA−AZ−6607−01 TCGA−AZ−6600−01 TCGA−AZ−5407−01 TCGA−AZ−4616−01 TCGA−AZ−4323−01 TCGA−AY−6196−01 TCGA−AY−4071−01 TCGA−AY−4070−01 TCGA−AU−3779−01 TCGA−AH−6643−01 TCGA−AH−6544−01 TCGA−AG−A036−01 TCGA−AG−A032−01 TCGA−AG−A02X−01 TCGA−AG−A02N−01 TCGA−AG−A026−01 TCGA−AG−A020−01 TCGA−AG−A01Y−01 TCGA−AG−A01W−01 TCGA−AG−A01L−01 TCGA−AG−A016−01 TCGA−AG−A014−01 TCGA−AG−A011−01 TCGA−AG−A00Y−01 TCGA−AG−A00C−01 TCGA−AG−4015−01 TCGA−AG−4008−01 TCGA−AG−4007−01 TCGA−AG−4005−01 TCGA−AG−3999−01 TCGA−AG−3909−01 TCGA−AG−3898−01 TCGA−AG−3896−01 TCGA−AG−3893−01 TCGA−AG−3890−01 TCGA−AG−3885−01 TCGA−AG−3882−01 TCGA−AG−3742−01 TCGA−AG−3731−01 TCGA−AG−3726−01 TCGA−AG−3612−01 TCGA−AG−3611−01 TCGA−AG−3609−01 TCGA−AG−3608−01 TCGA−AG−3605−01 TCGA−AG−3602−01 TCGA−AG−3601−01 TCGA−AG−3598−01 TCGA−AG−3594−01 TCGA−AG−3587−01 TCGA−AG−3581−01 TCGA−AG−3578−01 TCGA−AG−3575−01 TCGA−AF−4110−01 TCGA−AF−3913−01 TCGA−AF−3400−01 TCGA−AF−2691−01 TCGA−AF−2689−01 TCGA−AF−2687−01 TCGA−AD−6963−01 TCGA−AD−6899−01 TCGA−AD−6888−01 TCGA−AD−6548−01 TCGA−AA−A03J−01 TCGA−AA−A02W−01 TCGA−AA−A02J−01 TCGA−AA−A02H−01 TCGA−AA−A02F−01 TCGA−AA−A01Z−01 TCGA−AA−A01T−01 TCGA−AA−A01S−01 TCGA−AA−A01K−01 TCGA−AA−A01G−01 TCGA−AA−A01F−01 TCGA−AA−A01D−01 TCGA−AA−A00W−01 TCGA−AA−A00F−01 TCGA−AA−A00D−01 TCGA−AA−3982−01 TCGA−AA−3980−01 TCGA−AA−3979−01 TCGA−AA−3977−01 TCGA−AA−3976−01 TCGA−AA−3975−01 TCGA−AA−3972−01 TCGA−AA−3956−01 TCGA−AA−3930−01 TCGA−AA−3875−01 TCGA−AA−3869−01 TCGA−AA−3867−01 TCGA−AA−3866−01 TCGA−AA−3860−01 TCGA−AA−3858−01 TCGA−AA−3856−01 TCGA−AA−3851−01 TCGA−AA−3848−01 TCGA−AA−3844−01 TCGA−AA−3842−01 TCGA−AA−3814−01 TCGA−AA−3811−01 TCGA−AA−3713−01 TCGA−AA−3712−01 TCGA−AA−3693−01 TCGA−AA−3685−01 TCGA−AA−3681−01 TCGA−AA−3679−01 TCGA−AA−3667−01 TCGA−AA−3666−01 TCGA−AA−3662−01 TCGA−AA−3562−01 TCGA−AA−3561−01 TCGA−AA−3560−01 TCGA−AA−3558−01 TCGA−AA−3556−01 TCGA−AA−3553−01 TCGA−AA−3552−01 TCGA−AA−3549−01 TCGA−AA−3542−01 TCGA−AA−3531−01 TCGA−AA−3526−01 TCGA−AA−3524−01 TCGA−AA−3520−01 TCGA−AA−3519−01 TCGA−AA−3517−01 TCGA−AA−3511−01 TCGA−AA−3492−01 TCGA−A6−6782−01 TCGA−A6−6654−01 TCGA−A6−6652−01 TCGA−A6−6651−01 TCGA−A6−6649−01 TCGA−A6−6142−01 TCGA−A6−6138−01 TCGA−A6−6137−01 TCGA−A6−5656−01 TCGA−A6−3810−01 TCGA−A6−3807−01 TCGA−A6−2683−01 TCGA−A6−2678−01 TCGA−A6−2674−01 TCGA−A6−2670−01

TCGA−D5−6931−01 TCGA−AA−A01Q−01 TCGA−AA−3527−01 TCGA−AA−3525−01 TCGA−AA−3492−01 TCGA−AG−A00Y−01 TCGA−AA−3851−01 TCGA−AA−A00L−01 TCGA−AA−A00A−01 TCGA−AA−A01R−01 TCGA−AA−3542−01 TCGA−CM−6674−01 TCGA−CK−5916−01 TCGA−AA−A02K−01 TCGA−AA−3710−01 TCGA−A6−6141−01 TCGA−CM−4752−01 TCGA−AA−A00K−01 TCGA−AA−3980−01 TCGA−AA−3956−01 TCGA−AA−3949−01 TCGA−AA−3867−01 TCGA−AA−3854−01 TCGA−AA−3821−01 TCGA−AA−3666−01 TCGA−AA−3555−01 TCGA−A6−4105−01 TCGA−G4−6310−01 TCGA−DM−A1D4−01 TCGA−AF−6655−01 TCGA−A6−6653−01 TCGA−G5−6641−01 TCGA−G4−6321−01 TCGA−DY−A1DD−01 TCGA−DC−6681−01 TCGA−D5−5540−01 TCGA−CM−6163−01 TCGA−CM−6161−01 TCGA−CI−6624−01 TCGA−AA−3861−01 TCGA−AA−3697−01 TCGA−CA−6717−01 TCGA−AA−3715−01 TCGA−AA−3984−01 TCGA−AA−3516−01 TCGA−F5−6812−01 TCGA−EI−6507−01 TCGA−D5−5537−01 TCGA−AD−6964−01 TCGA−AA−A00E−01 TCGA−AA−3947−01 TCGA−AA−3877−01 TCGA−AA−3672−01 TCGA−AA−3518−01 TCGA−AA−3510−01 TCGA−A6−5665−01 TCGA−G4−6304−01 TCGA−F4−6460−01 TCGA−DM−A28H−01 TCGA−DM−A1D7−01 TCGA−D5−5538−01 TCGA−AU−3779−01 TCGA−AH−6643−01 TCGA−AH−6544−01 TCGA−AG−A02N−01 TCGA−AG−3731−01 TCGA−AD−6963−01 TCGA−AA−A029−01 TCGA−AA−A022−01 TCGA−AA−3973−01 TCGA−AA−3966−01 TCGA−AA−3818−01 TCGA−AA−3811−01 TCGA−AA−3662−01 TCGA−AG−A002−01 TCGA−AU−6004−01 TCGA−AA−A010−01 TCGA−AZ−6598−01 TCGA−AZ−4315−01 TCGA−AA−3815−01 TCGA−G4−6628−01 TCGA−G4−6586−01 TCGA−D5−6923−01 TCGA−D5−6535−01 TCGA−CM−6171−01 TCGA−CA−6718−01 TCGA−AY−6197−01 TCGA−AY−5543−01 TCGA−AA−3977−01 TCGA−AA−3663−01 TCGA−G4−6588−01 TCGA−G4−6307−01 TCGA−G4−6293−01 TCGA−F4−6808−01 TCGA−F4−6570−01 TCGA−EI−6510−01 TCGA−EF−5830−01 TCGA−D5−6540−01 TCGA−CM−6678−01 TCGA−CM−6168−01 TCGA−CM−6164−01 TCGA−CM−5864−01 TCGA−CM−5861−01 TCGA−CM−5349−01 TCGA−CM−5348−01 TCGA−CM−5344−01 TCGA−CK−6746−01 TCGA−CK−4948−01 TCGA−AZ−6605−01 TCGA−AZ−6601−01 TCGA−AZ−6599−01 TCGA−AH−6549−01 TCGA−AD−5900−01 TCGA−AA−3968−01 TCGA−A6−5666−01 TCGA−G4−6626−01 TCGA−G4−6625−01 TCGA−G4−6317−01 TCGA−G4−6315−01 TCGA−G4−6309−01 TCGA−F5−6811−01 TCGA−F5−6571−01 TCGA−F4−6856−01 TCGA−F4−6855−01 TCGA−F4−6807−01 TCGA−F4−6806−01 TCGA−DY−A1DG−01 TCGA−DY−A0XA−01 TCGA−DT−5265−01 TCGA−DM−A28K−01 TCGA−DM−A28G−01 TCGA−DM−A282−01 TCGA−DM−A1HA−01 TCGA−DM−A1DA−01 TCGA−DM−A1D8−01 TCGA−DC−6683−01 TCGA−DC−5337−01 TCGA−D5−6929−01 TCGA−D5−6928−01 TCGA−D5−6922−01 TCGA−D5−6537−01 TCGA−D5−6536−01 TCGA−D5−6533−01 TCGA−D5−6532−01 TCGA−CM−6680−01 TCGA−CM−6676−01 TCGA−CM−6170−01 TCGA−CM−6169−01 TCGA−CM−6166−01 TCGA−CM−5862−01 TCGA−CM−4746−01 TCGA−CM−4743−01 TCGA−CI−6620−01 TCGA−CA−6716−01 TCGA−CA−5255−01 TCGA−AZ−6608−01 TCGA−AZ−6603−01 TCGA−AZ−5403−01 TCGA−AG−3892−01 TCGA−AG−3732−01 TCGA−AF−6672−01 TCGA−AF−2693−01 TCGA−AD−6965−01 TCGA−AD−6889−01 TCGA−AA−3950−01 TCGA−AA−3864−01 TCGA−AA−3713−01 TCGA−AA−3655−01 TCGA−A6−6781−01 TCGA−A6−6651−01 TCGA−A6−5662−01 TCGA−A6−5661−01 TCGA−A6−5657−01 TCGA−A6−3809−01 TCGA−G5−6235−01 TCGA−G4−6323−01 TCGA−G4−6306−01 TCGA−G4−6303−01 TCGA−G4−6299−01 TCGA−F5−6813−01 TCGA−F5−6465−01 TCGA−F4−6854−01 TCGA−F4−6809−01 TCGA−F4−6805−01 TCGA−F4−6703−01 TCGA−F4−6569−01 TCGA−EI−6506−01 TCGA−DY−A1H8−01 TCGA−DY−A1DF−01 TCGA−DM−A28F−01 TCGA−DM−A28E−01 TCGA−DM−A28C−01 TCGA−DM−A1DB−01 TCGA−DM−A1D6−01 TCGA−DM−A0XF−01 TCGA−DM−A0XD−01 TCGA−DM−A0X9−01 TCGA−DC−6160−01 TCGA−DC−6157−01 TCGA−D5−7000−01 TCGA−D5−6932−01 TCGA−D5−6927−01 TCGA−D5−6924−01 TCGA−D5−6898−01 TCGA−D5−6539−01 TCGA−D5−6538−01 TCGA−D5−6534−01 TCGA−D5−6529−01 TCGA−D5−5541−01 TCGA−D5−5539−01 TCGA−CM−6677−01 TCGA−CM−6675−01 TCGA−CM−6172−01 TCGA−CM−6167−01 TCGA−CM−6165−01 TCGA−CM−6162−01 TCGA−CM−5868−01 TCGA−CM−5860−01 TCGA−CM−4747−01 TCGA−CL−5917−01 TCGA−CK−6748−01 TCGA−CK−6747−01 TCGA−CK−5915−01 TCGA−CK−5914−01 TCGA−CK−5913−01 TCGA−CK−5912−01 TCGA−CK−4952−01 TCGA−CK−4950−01 TCGA−CK−4947−01 TCGA−CI−6622−01 TCGA−CI−6619−01 TCGA−CA−5796−01 TCGA−CA−5254−01 TCGA−AZ−6606−01 TCGA−AZ−5407−01 TCGA−AZ−4682−01 TCGA−AZ−4616−01 TCGA−AY−6386−01 TCGA−AH−6547−01 TCGA−AG−3901−01 TCGA−AG−3885−01 TCGA−AF−6136−01 TCGA−AF−5654−01 TCGA−AF−2687−01 TCGA−AD−6901−01 TCGA−AD−6895−01 TCGA−AD−6888−01 TCGA−AA−3712−01 TCGA−AA−3692−01 TCGA−AA−3660−01 TCGA−AA−3502−01 TCGA−AA−3496−01 TCGA−A6−6780−01 TCGA−A6−6652−01 TCGA−A6−6649−01 TCGA−A6−6648−01 TCGA−A6−5664−01 TCGA−A6−5660−01 TCGA−A6−5659−01 TCGA−A6−5656−01 TCGA−A6−2671−01

Neurophilin Interactions With VEGF And VEGFR FDR = 0.68%, FDR nod = 0.78%

unknown CG mut

JNK Cascade ( EGF Signaling Pathway Diagram ) JNK Cascade ( PDGF Signaling Pathway ) FDR = 0.00054%, FDR nod = 0.0011%

SLC11A2 wt

TCEB2 CGB5

TP53 PTEN

VHL CREBBP

HIF1A MTOR

EGLN2 AKT2

HSP90AA1 ARNT

OS9 EGLN2

EGLN1 AKT3

TCEB1 TXN

TCEB2 TXN2

known HCG mut KDR


EGLN3

CDKN2A GPR37

COPS5

wt

KDR

MAPK8

NRP2

JUN

NRP1

known HCG mut FLT1

wt SLC2A1

wt ARNT wt HIF1A

EGLN3 unknown CG mut

unknown CG mut VHL

known HCG mut CUL2 known HCG mut VHL

MMP14 known HCG mut

PGK1

STAR

CREBBP EP300 FLT1

EIF3E ETS1

ABCG2 EPAS1 SP1

ADORA2A APEX1 ARNT

BHLHE40 EFNA1

HIF1AN

[CGB Protein Results In Increased Activity Of LHCGR Protein] Nitrophenyl)methanesulfonamide Results In Decreased Activity Of PTGS2 Protein] Inhibits The Reaction [CGB Protein Results In Increased Chemical Synthesis Of Dinoprost] ethyl)phenyl)methyl) 7H Pyrrolo(3, 2 F)quinazoline 1,3 Diamine Binds To F2R Protein] Promotes The Reaction [CGB Protein Results In Increased Chemical Synthesis Of Progesterone] Atrazine Inhibits The Reaction [CGB Protein Results In Increased Chemical Synthesis Of Androgens] Atrazine Inhibits The Reaction [CGB Protein Results In Increased Secretion Of Cyclic AMP] Colforsin Promotes The Reaction [CGB Protein Results In Increased Abundance Of Cyclic AMP] Finasteride Promotes The Reaction [[Gonadotropins, Equine Co Treated With CGB Protein] Results In Increased Abundance Of Progesterone] Flame Retardants Inhibits The Reaction [[CGB Protein Co Treated With Colforsin] Results In Increased Abundance Of Cyclic AMP] KISS1 Protein Promotes The Reaction [CGB Protein Results In Increased Abundance Of Progesterone] Lansoprazole Metabolite Inhibits The Reaction [CGB Protein Results In Increased Abundance Of Testosterone] Manganese Chloride Inhibits The Reaction [CGB Protein Results In Increased Expression Of STAR Protein] Progesterone Promotes The Reaction [CGB Protein Results In Increased Expression Of VEGFA MRNA] Testosterone Enanthate Inhibits The Reaction [CGB Protein Results In Increased Abundance Of Androgens] FDR = 0.0063%, FDR nod = 0.012%

TWIST1 CITED2 EGLN1

EGLN2

EPO FXN

POU5F1

SERPINE1

TCEB1

VEGFA

HIF3A

PARK2

EGLN3

AKT1

HIF1AN NAA10

EGLN1

RACK1 RBX1

unknown CG mut

known HCG mut MAP2K4

wt

TCGA−G4−6303−01 TCGA−F4−6856−01 TCGA−CM−6162−01 TCGA−AH−6643−01 TCGA−AA−3510−01 TCGA−A6−5661−01 TCGA−A6−4105−01 TCGA−F4−6570−01 TCGA−CM−4743−01 TCGA−AU−6004−01 TCGA−AA−3864−01 TCGA−AA−3821−01 TCGA−AA−3710−01 TCGA−AA−3520−01 TCGA−A6−6138−01 TCGA−AY−6197−01 TCGA−G4−6628−01 TCGA−G4−6315−01 TCGA−DM−A28F−01 TCGA−DM−A1D9−01 TCGA−D5−6932−01 TCGA−D5−6931−01 TCGA−D5−6929−01 TCGA−D5−6539−01 TCGA−CM−6168−01 TCGA−CM−6161−01 TCGA−CK−5915−01 TCGA−AZ−6598−01 TCGA−AG−A02N−01 TCGA−AD−6895−01 TCGA−AA−A022−01 TCGA−AA−3984−01 TCGA−AA−3697−01 TCGA−AA−3555−01 TCGA−AA−3489−01 TCGA−A6−5665−01 TCGA−CA−6718−01 TCGA−CA−6717−01 TCGA−AZ−4315−01 TCGA−AG−A002−01 TCGA−G4−6588−01 TCGA−DY−A0XA−01 TCGA−AF−5654−01 TCGA−AA−A010−01 TCGA−AA−A00N−01 TCGA−AA−3977−01 TCGA−AA−3950−01 TCGA−AA−3949−01 TCGA−AA−3715−01 TCGA−AA−3663−01 TCGA−A6−6780−01 TCGA−G4−6293−01 TCGA−F4−6854−01 TCGA−F4−6703−01 TCGA−EI−6507−01 TCGA−DY−A1DD−01 TCGA−DM−A28E−01 TCGA−CM−5862−01 TCGA−CM−5860−01 TCGA−CA−5797−01 TCGA−AZ−6599−01 TCGA−AZ−5403−01 TCGA−AU−3779−01 TCGA−AG−3878−01 TCGA−AF−6136−01 TCGA−AF−4110−01 TCGA−AA−A01Q−01 TCGA−AA−3966−01 TCGA−AA−3877−01 TCGA−A6−5662−01

TCGA−D5−6928−01 TCGA−F4−6570−01 TCGA−CM−5349−01 TCGA−CM−4743−01 TCGA−CL−5918−01 TCGA−AZ−6601−01 TCGA−AZ−4323−01 TCGA−AU−3779−01 TCGA−AG−A02N−01 TCGA−AG−A002−01 TCGA−AG−3892−01 TCGA−AD−6889−01 TCGA−AA−A01Q−01 TCGA−AA−3877−01 TCGA−A6−5665−01 TCGA−CM−6172−01 TCGA−G4−6628−01 TCGA−F5−6812−01 TCGA−DM−A1DA−01 TCGA−DC−5337−01 TCGA−D5−6539−01 TCGA−D5−6535−01 TCGA−CM−6171−01 TCGA−CK−6746−01 TCGA−CK−4952−01 TCGA−CK−4948−01 TCGA−CK−4947−01 TCGA−CA−6718−01 TCGA−CA−6716−01 TCGA−AZ−6598−01 TCGA−AY−6196−01 TCGA−AG−A00Y−01 TCGA−AG−3727−01 TCGA−AD−6901−01 TCGA−AD−6899−01 TCGA−AD−6548−01 TCGA−AA−A010−01 TCGA−AA−A00N−01 TCGA−AA−3986−01 TCGA−AA−3966−01 TCGA−AA−3952−01 TCGA−AA−3864−01 TCGA−AA−3861−01 TCGA−AA−3845−01 TCGA−AA−3814−01 TCGA−AA−3672−01 TCGA−AA−3492−01 TCGA−A6−6141−01 TCGA−A6−5666−01

PDGF Pathway FDR = 8.9e−10%, FDR nod = 0.0023% Oxygen Dependent Proline Hydroxylation Of Hypoxia Inducible Factor Alpha FDR = 0.01%, FDR nod = 0.0092%

SRF

STAT5B

SHF

STAT5A

SHB

RASA1

JUN

PIK3R2

ELK1

PIK3CB

CSNK2A1

PDGFA

GRB2

HRAS

FOS

ARHGEF6

SHC1 PDGFRB

CAV1

RAF1

PLCG1 PIK3R1

RAPGEF1

GRB2

PDGFRA PIK3CA

JAK1

SHC3

PIK3CA KRAS

PIK3R1 VHL

TIAM1 CUL2

VAV1 HIF1A

WASL UBC

ARFIP2 UBE2D1

UBE2D2

CDC42

UBE2D3

RAC1



PDGFRB PDGFRB

wt wt

PDGFB PDGFB


SOS1

ITGAV

PIK3CD

SOS2

CAV3

CDC42

NCK1

PRRT2

PAK1

PDGFB

CRKL

SHC2

wt SOS1 wt SHC1

TCGA−AA−3562−01 TCGA−AH−6643−01 TCGA−CM−5348−01 TCGA−AA−3525−01 TCGA−A6−6781−01 TCGA−CM−6161−01 TCGA−AA−3712−01 TCGA−AA−3543−01 TCGA−G4−6588−01 TCGA−G4−6309−01 TCGA−AA−A01D−01 TCGA−A6−2672−01 TCGA−AA−3949−01 TCGA−AA−3516−01 TCGA−F5−6811−01 TCGA−D5−6540−01 TCGA−AG−3601−01 TCGA−CM−5861−01 TCGA−CK−6746−01 TCGA−CK−5913−01 TCGA−AD−5900−01 TCGA−AA−A01Q−01 TCGA−AA−3811−01 TCGA−A6−6780−01 TCGA−D5−6533−01 TCGA−CK−5916−01 TCGA−AZ−6603−01 TCGA−AA−3971−01 TCGA−AA−3866−01 TCGA−AA−3845−01 TCGA−AA−3815−01 TCGA−AA−3534−01 TCGA−AG−A002−01 TCGA−AA−A010−01 TCGA−F4−6570−01 TCGA−F4−6460−01 TCGA−CM−5349−01 TCGA−CA−6717−01 TCGA−AY−6197−01 TCGA−AA−3947−01 TCGA−AA−3672−01 TCGA−AA−3510−01 TCGA−G4−6310−01 TCGA−F4−6459−01 TCGA−DM−A0XF−01 TCGA−D5−6928−01 TCGA−D5−6922−01 TCGA−CM−6675−01 TCGA−CM−6172−01 TCGA−CM−5868−01 TCGA−CM−5344−01 TCGA−CA−6715−01 TCGA−AZ−4323−01 TCGA−AY−6196−01 TCGA−AA−3984−01 TCGA−AA−3952−01 TCGA−DM−A1DA−01 TCGA−CM−6162−01 TCGA−F5−6465−01 TCGA−DC−6682−01 TCGA−AF−6136−01 TCGA−AA−A01V−01 TCGA−AA−3666−01 TCGA−AA−3662−01 TCGA−G4−6315−01 TCGA−G4−6307−01 TCGA−G4−6304−01 TCGA−DC−5337−01 TCGA−CM−6680−01 TCGA−CM−5864−01 TCGA−CA−5797−01 TCGA−AG−A01L−01 TCGA−AG−3894−01 TCGA−AF−3913−01 TCGA−AA−A02F−01 TCGA−AA−A024−01 TCGA−AA−A00F−01 TCGA−AA−3976−01 TCGA−AA−3973−01 TCGA−AA−3972−01 TCGA−AA−3850−01 TCGA−AA−3819−01 TCGA−AA−3549−01 TCGA−A6−2678−01 TCGA−AA−A00N−01 TCGA−G4−6586−01 TCGA−AZ−4315−01 TCGA−AA−3864−01 TCGA−EI−6510−01 TCGA−DM−A1D9−01 TCGA−D5−6539−01 TCGA−CM−4746−01 TCGA−CK−4950−01 TCGA−AZ−5407−01 TCGA−AG−3892−01 TCGA−AD−6895−01 TCGA−AA−A01R−01 TCGA−AA−3713−01 TCGA−A6−5666−01 TCGA−A6−5665−01 TCGA−A6−5661−01 TCGA−G5−6235−01 TCGA−G4−6625−01 TCGA−F4−6856−01 TCGA−F4−6703−01 TCGA−DM−A28H−01 TCGA−DM−A282−01 TCGA−DM−A1D7−01 TCGA−DM−A1D4−01 TCGA−DM−A0X9−01 TCGA−D5−7000−01 TCGA−D5−6932−01 TCGA−D5−6930−01 TCGA−D5−6927−01 TCGA−D5−6538−01 TCGA−D5−6536−01 TCGA−D5−5538−01 TCGA−CM−4743−01 TCGA−CK−4948−01 TCGA−CI−6622−01 TCGA−CA−6718−01 TCGA−CA−6716−01 TCGA−AZ−6601−01 TCGA−AY−6386−01 TCGA−AG−3727−01 TCGA−AF−2691−01 TCGA−AD−6964−01 TCGA−AD−6889−01 TCGA−AA−A00A−01 TCGA−AA−3979−01 TCGA−AA−3977−01 TCGA−AA−3660−01 TCGA−AA−3558−01 TCGA−AA−3555−01 TCGA−A6−6782−01 TCGA−A6−6654−01 TCGA−A6−6653−01 TCGA−A6−6141−01 TCGA−A6−5659−01 TCGA−G4−6626−01 TCGA−G4−6323−01 TCGA−G4−6306−01 TCGA−F5−6812−01 TCGA−F5−6702−01 TCGA−F5−6571−01 TCGA−F4−6855−01 TCGA−F4−6854−01 TCGA−F4−6807−01 TCGA−F4−6806−01 TCGA−F4−6805−01 TCGA−EI−6507−01 TCGA−EI−6506−01 TCGA−EF−5830−01 TCGA−DY−A1H8−01 TCGA−DY−A1DF−01 TCGA−DM−A28K−01 TCGA−DM−A28G−01 TCGA−DM−A285−01 TCGA−DM−A1HA−01 TCGA−DM−A1DB−01 TCGA−DM−A1D8−01 TCGA−DM−A1D6−01 TCGA−DM−A1D0−01 TCGA−DM−A0XD−01 TCGA−DC−6683−01 TCGA−DC−6160−01 TCGA−DC−6155−01 TCGA−D5−6931−01 TCGA−D5−6541−01 TCGA−D5−6537−01 TCGA−D5−6535−01 TCGA−D5−6532−01 TCGA−D5−6529−01 TCGA−D5−5540−01 TCGA−D5−5539−01 TCGA−D5−5537−01 TCGA−CM−6678−01 TCGA−CM−6674−01 TCGA−CM−6168−01 TCGA−CM−6166−01 TCGA−CM−6164−01 TCGA−CM−6163−01 TCGA−CM−5863−01 TCGA−CM−5862−01 TCGA−CM−4747−01 TCGA−CM−4744−01 TCGA−CL−5917−01 TCGA−CK−4947−01 TCGA−CI−6620−01 TCGA−CA−5796−01 TCGA−AZ−6608−01 TCGA−AZ−6607−01 TCGA−AZ−6606−01 TCGA−AZ−6605−01 TCGA−AZ−6600−01 TCGA−AZ−6599−01 TCGA−AZ−6598−01 TCGA−AZ−4616−01 TCGA−AY−5543−01 TCGA−AH−6644−01 TCGA−AH−6544−01 TCGA−AG−A032−01 TCGA−AG−A02X−01 TCGA−AG−A02N−01 TCGA−AG−A025−01 TCGA−AG−A020−01 TCGA−AG−A01W−01 TCGA−AG−A015−01 TCGA−AG−A014−01 TCGA−AG−A00Y−01 TCGA−AG−A00H−01 TCGA−AG−A00C−01 TCGA−AG−A008−01 TCGA−AG−4008−01 TCGA−AG−4005−01 TCGA−AG−3999−01 TCGA−AG−3909−01 TCGA−AG−3902−01 TCGA−AG−3901−01 TCGA−AG−3896−01 TCGA−AG−3887−01 TCGA−AG−3885−01 TCGA−AG−3878−01 TCGA−AG−3742−01 TCGA−AG−3731−01 TCGA−AG−3726−01 TCGA−AG−3611−01 TCGA−AG−3605−01 TCGA−AG−3602−01 TCGA−AG−3599−01 TCGA−AG−3594−01 TCGA−AG−3586−01 TCGA−AG−3583−01 TCGA−AG−3581−01 TCGA−AG−3580−01 TCGA−AG−3575−01 TCGA−AF−6672−01 TCGA−AF−6655−01 TCGA−AF−5654−01 TCGA−AF−4110−01 TCGA−AF−2692−01 TCGA−AF−2689−01 TCGA−AD−6965−01 TCGA−AD−6901−01 TCGA−AD−6548−01 TCGA−AA−A03J−01 TCGA−AA−A03F−01 TCGA−AA−A02Y−01 TCGA−AA−A02W−01 TCGA−AA−A02O−01 TCGA−AA−A029−01 TCGA−AA−A01Z−01 TCGA−AA−A01X−01 TCGA−AA−A01K−01 TCGA−AA−A01I−01 TCGA−AA−A01G−01 TCGA−AA−A01F−01 TCGA−AA−A00Q−01 TCGA−AA−A00K−01 TCGA−AA−3994−01 TCGA−AA−3986−01 TCGA−AA−3975−01 TCGA−AA−3941−01 TCGA−AA−3939−01 TCGA−AA−3930−01 TCGA−AA−3870−01 TCGA−AA−3854−01 TCGA−AA−3852−01 TCGA−AA−3851−01 TCGA−AA−3848−01 TCGA−AA−3844−01 TCGA−AA−3842−01 TCGA−AA−3837−01 TCGA−AA−3818−01 TCGA−AA−3814−01 TCGA−AA−3715−01 TCGA−AA−3696−01 TCGA−AA−3695−01 TCGA−AA−3681−01 TCGA−AA−3680−01 TCGA−AA−3673−01 TCGA−AA−3663−01 TCGA−AA−3655−01 TCGA−AA−3561−01 TCGA−AA−3560−01 TCGA−AA−3556−01 TCGA−AA−3548−01 TCGA−AA−3532−01 TCGA−AA−3530−01 TCGA−AA−3522−01 TCGA−AA−3521−01 TCGA−AA−3520−01 TCGA−AA−3511−01 TCGA−AA−3502−01 TCGA−A6−6138−01 TCGA−A6−5664−01 TCGA−A6−5662−01 TCGA−A6−5657−01 TCGA−A6−4105−01 TCGA−A6−3808−01 TCGA−A6−2683−01

TCGA−A6−6782−01 TCGA−G4−6588−01 TCGA−AH−6643−01 TCGA−G4−6306−01 TCGA−CM−6168−01 TCGA−AD−6963−01 TCGA−AA−A02K−01 TCGA−AA−3710−01 TCGA−A6−6781−01 TCGA−F4−6569−01 TCGA−D5−6931−01 TCGA−D5−6541−01 TCGA−D5−6540−01 TCGA−AA−3877−01 TCGA−AA−3848−01 TCGA−AA−3715−01 TCGA−DM−A0X9−01 TCGA−D5−6930−01 TCGA−D5−6927−01 TCGA−D5−6533−01 TCGA−CK−5916−01 TCGA−AZ−6603−01 TCGA−AZ−6601−01 TCGA−AD−6889−01 TCGA−AA−3971−01 TCGA−AA−3866−01 TCGA−AA−3845−01 TCGA−AA−3815−01 TCGA−AA−3713−01 TCGA−AA−3534−01 TCGA−A6−6654−01 TCGA−F4−6460−01 TCGA−AG−A002−01 TCGA−AD−6895−01 TCGA−AA−A010−01 TCGA−EI−6510−01 TCGA−CM−5349−01 TCGA−CK−4950−01 TCGA−CA−6717−01 TCGA−AZ−4323−01 TCGA−AA−A01R−01 TCGA−A6−5665−01 TCGA−G5−6235−01 TCGA−G4−6586−01 TCGA−G4−6310−01 TCGA−F5−6465−01 TCGA−F4−6570−01 TCGA−F4−6459−01 TCGA−DM−A282−01 TCGA−DM−A1DA−01 TCGA−DM−A1D9−01 TCGA−DM−A1D7−01 TCGA−DM−A1D4−01 TCGA−DM−A0XF−01 TCGA−D5−7000−01 TCGA−D5−6928−01 TCGA−D5−6922−01 TCGA−D5−6539−01 TCGA−CM−6675−01 TCGA−CM−6172−01 TCGA−CM−5868−01 TCGA−CM−5344−01 TCGA−CA−6716−01 TCGA−CA−6715−01 TCGA−AZ−5407−01 TCGA−AZ−4315−01 TCGA−AY−6386−01 TCGA−AY−6197−01 TCGA−AY−6196−01 TCGA−AG−3892−01 TCGA−AA−A00N−01 TCGA−AA−3984−01 TCGA−AA−3952−01 TCGA−AA−3947−01 TCGA−AA−3864−01 TCGA−AA−3672−01 TCGA−AA−3666−01 TCGA−AA−3662−01 TCGA−AA−3660−01 TCGA−AA−3510−01 TCGA−A6−5666−01 TCGA−A6−5659−01

PDGFR Alpha Signaling Pathway FDR = 1.9e−12%, FDR nod = 0.0023% PDGF Signaling Pathway (Mammal) ( PDGF Signaling Pathway ) FDR = 1.9e−12%, FDR nod = 0.16%


PIK3R1 PDGFRA

TCGA−DM−A0X9−01 TCGA−AA−3966−01 TCGA−CK−6746−01 TCGA−A6−6653−01 TCGA−F4−6570−01 TCGA−DM−A1HA−01 TCGA−AD−5900−01 TCGA−AA−3514−01 TCGA−DC−6158−01 TCGA−D5−6928−01 TCGA−AZ−5403−01 TCGA−AA−3715−01 TCGA−AD−6899−01 TCGA−AA−A00R−01 TCGA−AA−A00K−01 TCGA−AA−3815−01 TCGA−F4−6703−01 TCGA−D5−6539−01 TCGA−AD−6963−01 TCGA−AA−A022−01 TCGA−G4−6310−01 TCGA−CM−6678−01 TCGA−CK−4948−01 TCGA−AA−A01P−01 TCGA−AA−3972−01 TCGA−AA−3845−01 TCGA−DM−A28H−01 TCGA−CM−6162−01 TCGA−CM−4746−01 TCGA−AA−A01V−01 TCGA−AA−3562−01 TCGA−AA−3516−01 TCGA−D5−6536−01 TCGA−AA−3663−01 TCGA−G4−6625−01 TCGA−G4−6586−01 TCGA−D5−6541−01 TCGA−D5−6537−01 TCGA−D5−6533−01 TCGA−CM−5861−01 TCGA−CK−4947−01 TCGA−AA−3534−01 TCGA−AA−A01R−01 TCGA−A6−5661−01 TCGA−G4−6303−01 TCGA−D5−6535−01 TCGA−CM−5348−01 TCGA−AY−6386−01 TCGA−AA−A02O−01 TCGA−AA−A01G−01 TCGA−AA−3950−01 TCGA−AA−3821−01 TCGA−AA−3672−01 TCGA−AA−3531−01 TCGA−AA−3525−01 TCGA−AA−3510−01 TCGA−CA−6718−01 TCGA−F4−6856−01 TCGA−CI−6624−01 TCGA−AZ−5407−01 TCGA−AA−A02K−01 TCGA−AA−3555−01 TCGA−G4−6304−01 TCGA−DM−A1D8−01 TCGA−DC−6681−01 TCGA−D5−6534−01 TCGA−CM−6677−01 TCGA−CA−6719−01 TCGA−AZ−6607−01 TCGA−A6−5659−01 TCGA−CM−4743−01 TCGA−G4−6628−01 TCGA−G4−6588−01 TCGA−AZ−6598−01 TCGA−AA−A00N−01 TCGA−AA−3977−01 TCGA−AA−3947−01 TCGA−AA−3864−01 TCGA−CM−5349−01 TCGA−AG−A02N−01 TCGA−AA−A00A−01 TCGA−A6−6141−01 TCGA−DT−5265−01 TCGA−DC−6155−01 TCGA−DC−5869−01 TCGA−D5−6540−01 TCGA−D5−6538−01 TCGA−CM−6679−01 TCGA−AZ−6601−01 TCGA−AG−3609−01 TCGA−AA−A01Z−01 TCGA−AA−3975−01 TCGA−AA−3693−01 TCGA−AA−3492−01 TCGA−A6−5657−01 TCGA−AG−A002−01 TCGA−AA−A010−01 TCGA−CA−6717−01 TCGA−AZ−4315−01 TCGA−CK−5916−01 TCGA−A6−6781−01 TCGA−G4−6626−01 TCGA−CM−6161−01 TCGA−CK−4950−01 TCGA−AG−3892−01 TCGA−AA−3984−01 TCGA−AA−3662−01 TCGA−D5−6532−01 TCGA−CM−6674−01 TCGA−CM−6171−01 TCGA−CM−5862−01 TCGA−AU−6004−01 TCGA−AU−3779−01 TCGA−AD−6895−01 TCGA−AA−3697−01 TCGA−G4−6315−01 TCGA−G4−6309−01 TCGA−G4−6307−01 TCGA−F4−6460−01 TCGA−EI−6508−01 TCGA−EI−6507−01 TCGA−DY−A1DG−01 TCGA−DM−A1DB−01 TCGA−DM−A1D9−01 TCGA−DM−A0XD−01 TCGA−D5−6927−01 TCGA−D5−6922−01 TCGA−D5−5541−01 TCGA−CM−6167−01 TCGA−CM−6164−01 TCGA−CM−4752−01 TCGA−CK−5914−01 TCGA−AZ−6608−01 TCGA−AY−5543−01 TCGA−AH−6549−01 TCGA−AG−A025−01 TCGA−AG−3726−01 TCGA−AA−3833−01 TCGA−AA−3664−01 TCGA−AA−3552−01 TCGA−AA−3511−01 TCGA−A6−6780−01 TCGA−A6−5665−01 TCGA−A6−5660−01 TCGA−A6−5656−01

TCGA−A6−6652−01 TCGA−AG−3887−01 TCGA−AA−3527−01 TCGA−CM−6162−01 TCGA−AA−3715−01 TCGA−AA−3947−01 TCGA−AA−3525−01 TCGA−AA−3815−01 TCGA−AA−3710−01 TCGA−CK−5913−01 TCGA−AG−3583−01 TCGA−AA−3975−01 TCGA−AA−3864−01 TCGA−CA−6718−01 TCGA−CM−6674−01 TCGA−CK−5916−01 TCGA−AA−A02K−01 TCGA−AA−A00E−01 TCGA−AA−3950−01 TCGA−A6−3809−01 TCGA−G4−6588−01 TCGA−AA−A022−01 TCGA−AZ−6606−01 TCGA−AZ−6601−01 TCGA−AA−A00N−01 TCGA−AA−3949−01 TCGA−AA−3877−01 TCGA−A6−2676−01 TCGA−AA−A010−01 TCGA−CA−6717−01 TCGA−AZ−4315−01 TCGA−D5−6928−01 TCGA−AZ−6598−01 TCGA−AD−6889−01 TCGA−D5−6538−01 TCGA−CM−4743−01 TCGA−AA−A01Q−01 TCGA−AA−3966−01 TCGA−AA−3555−01 TCGA−AG−A002−01 TCGA−G4−6628−01 TCGA−CM−5349−01 TCGA−AA−3663−01 TCGA−A6−6653−01 TCGA−G4−6315−01 TCGA−G4−6310−01 TCGA−F5−6812−01 TCGA−D5−6540−01 TCGA−D5−6532−01 TCGA−CM−5861−01 TCGA−CK−6746−01 TCGA−CI−6624−01 TCGA−AY−6197−01 TCGA−AU−6004−01 TCGA−AD−6964−01 TCGA−AD−5900−01 TCGA−A6−4105−01 TCGA−G5−6641−01 TCGA−G4−6626−01 TCGA−G4−6321−01 TCGA−G4−6293−01 TCGA−F5−6811−01 TCGA−F4−6855−01 TCGA−F4−6807−01 TCGA−F4−6570−01 TCGA−EI−6510−01 TCGA−EF−5830−01 TCGA−DY−A1DD−01 TCGA−DY−A0XA−01 TCGA−DM−A28G−01 TCGA−DM−A1D4−01 TCGA−DC−6683−01 TCGA−DC−6681−01 TCGA−DC−5337−01 TCGA−D5−6929−01 TCGA−D5−6923−01 TCGA−D5−6922−01 TCGA−D5−6537−01 TCGA−D5−6536−01 TCGA−D5−6535−01 TCGA−D5−6533−01 TCGA−D5−5540−01 TCGA−CM−6678−01 TCGA−CM−6676−01 TCGA−CM−6171−01 TCGA−CM−6170−01 TCGA−CM−6169−01 TCGA−CM−6168−01 TCGA−CM−6164−01 TCGA−CM−6163−01 TCGA−CM−6161−01 TCGA−CM−5864−01 TCGA−CM−5862−01 TCGA−CM−5348−01 TCGA−CM−5344−01 TCGA−CK−4948−01 TCGA−CA−5255−01 TCGA−AZ−6608−01 TCGA−AZ−6605−01 TCGA−AZ−6603−01 TCGA−AZ−6599−01 TCGA−AZ−5403−01 TCGA−AY−5543−01 TCGA−AH−6549−01 TCGA−AG−3732−01 TCGA−AF−6672−01 TCGA−AF−6655−01 TCGA−AF−2693−01 TCGA−AD−6965−01 TCGA−AA−3968−01 TCGA−AA−3861−01 TCGA−AA−3697−01 TCGA−AA−3655−01 TCGA−A6−5666−01 TCGA−A6−5665−01 TCGA−A6−5662−01 TCGA−A6−5657−01

PDGF Signaling Pathway ( PDGF Signaling Pathway ) FDR = 1.9e−12%, FDR nod = 0.00016% PDGF Receptor Signaling Network FDR = 7e−08%, FDR nod = 1.2e−07%

wt wt EPAS1


CHUK HIF3A


EGLN2

VAV2

UBA52

RAF1

EGLN3

RHOA

RBX1

PAK1

EGLN1

SRC

TCEB1

TCEB2

STAT1

STAT3

PDGFRA

KRAS

NRAS

PDGFRA

SHC1

PDGFD

SOS1

SOS2

PDGFC

GRB2

HRAS

SHC3

PDGFA

PDGFA

RAF1

SHC2

NRAS

PTPN11

TCGA−AA−A00J−01 TCGA−DM−A28K−01 TCGA−AA−3543−01 TCGA−DM−A1D6−01 TCGA−AG−3605−01 TCGA−AD−6889−01 TCGA−AA−3966−01 TCGA−AA−A01P−01 TCGA−AA−3710−01 TCGA−AG−A011−01 TCGA−AA−3973−01 TCGA−G4−6306−01 TCGA−AY−4070−01 TCGA−AG−A02G−01 TCGA−AA−3949−01 TCGA−F4−6703−01 TCGA−AG−3601−01 TCGA−AA−3516−01 TCGA−D5−6533−01 TCGA−CK−5913−01 TCGA−AA−3979−01 TCGA−AA−3811−01 TCGA−AA−A01Q−01 TCGA−D5−6930−01 TCGA−CI−6621−01 TCGA−AA−3972−01 TCGA−A6−6653−01 TCGA−A6−6781−01 TCGA−G4−6626−01 TCGA−G4−6309−01 TCGA−EI−6508−01 TCGA−CM−6167−01 TCGA−AH−6549−01 TCGA−AG−A025−01 TCGA−AG−3726−01 TCGA−AA−3833−01 TCGA−AA−3664−01 TCGA−AA−3552−01 TCGA−AG−A002−01 TCGA−AA−3984−01 TCGA−D5−6928−01 TCGA−AD−6895−01 TCGA−AA−A01R−01 TCGA−DM−A1DA−01 TCGA−D5−6922−01 TCGA−CA−6716−01 TCGA−AY−6196−01 TCGA−AG−3892−01 TCGA−F5−6465−01 TCGA−EI−6510−01 TCGA−DM−A282−01 TCGA−DM−A1D4−01 TCGA−D5−6539−01 TCGA−CM−6675−01 TCGA−CM−5868−01 TCGA−CA−6715−01 TCGA−AZ−4323−01 TCGA−AA−3952−01 TCGA−AA−3672−01 TCGA−AA−3666−01 TCGA−AZ−4315−01 TCGA−AY−6197−01 TCGA−CA−6717−01 TCGA−CK−4948−01 TCGA−AA−A010−01 TCGA−AA−A00N−01 TCGA−AA−3864−01 TCGA−G4−6628−01 TCGA−G4−6586−01 TCGA−CM−6674−01 TCGA−CM−6171−01 TCGA−CM−5861−01 TCGA−AD−6964−01 TCGA−AD−5900−01 TCGA−AA−3663−01 TCGA−AA−3510−01 TCGA−A6−6780−01 TCGA−A6−5665−01 TCGA−G4−6588−01 TCGA−F5−6811−01 TCGA−F4−6856−01 TCGA−F4−6460−01 TCGA−F4−6459−01 TCGA−EI−6507−01 TCGA−DM−A1DB−01 TCGA−DM−A1D9−01 TCGA−D5−6540−01 TCGA−CM−6172−01 TCGA−CM−6162−01 TCGA−CM−5860−01 TCGA−CM−4746−01 TCGA−CK−6746−01 TCGA−CK−4952−01 TCGA−CK−4950−01 TCGA−AZ−6598−01 TCGA−AU−6004−01 TCGA−AA−3977−01 TCGA−AA−3947−01 TCGA−AA−3877−01 TCGA−AA−3713−01 TCGA−AA−3697−01 TCGA−AA−3662−01 TCGA−AA−3492−01 TCGA−A6−5659−01 TCGA−G5−6235−01 TCGA−G4−6625−01 TCGA−G4−6323−01 TCGA−G4−6315−01 TCGA−G4−6310−01 TCGA−G4−6307−01 TCGA−G4−6304−01 TCGA−F4−6570−01 TCGA−DY−A1DG−01 TCGA−DM−A1D7−01 TCGA−DM−A0XF−01 TCGA−DM−A0XD−01 TCGA−DM−A0X9−01 TCGA−DC−6682−01 TCGA−D5−7000−01 TCGA−D5−6927−01 TCGA−D5−6923−01 TCGA−D5−6898−01 TCGA−D5−6538−01 TCGA−D5−6536−01 TCGA−D5−6532−01 TCGA−D5−5541−01 TCGA−D5−5540−01 TCGA−CM−6166−01 TCGA−CM−6164−01 TCGA−CM−6161−01 TCGA−CM−5864−01 TCGA−CM−5862−01 TCGA−CM−5349−01 TCGA−CM−5344−01 TCGA−CM−4752−01 TCGA−CK−5916−01 TCGA−CK−5914−01 TCGA−CK−4947−01 TCGA−CI−6622−01 TCGA−CA−6718−01 TCGA−AZ−6608−01 TCGA−AZ−6601−01 TCGA−AZ−5407−01 TCGA−AY−6386−01 TCGA−AY−5543−01 TCGA−AU−3779−01 TCGA−AF−6136−01 TCGA−AD−6965−01 TCGA−AA−3950−01 TCGA−AA−3715−01 TCGA−AA−3712−01 TCGA−AA−3660−01 TCGA−AA−3511−01 TCGA−AA−3489−01 TCGA−A6−6654−01 TCGA−A6−5666−01 TCGA−A6−5662−01 TCGA−A6−5661−01 TCGA−A6−5660−01 TCGA−A6−5657−01 TCGA−A6−5656−01 TCGA−G4−6317−01 TCGA−G4−6303−01 TCGA−G4−6299−01 TCGA−G4−6293−01 TCGA−F5−6813−01 TCGA−F5−6571−01 TCGA−F4−6855−01 TCGA−F4−6854−01 TCGA−F4−6809−01 TCGA−F4−6808−01 TCGA−F4−6807−01 TCGA−F4−6805−01 TCGA−F4−6569−01 TCGA−EF−5830−01 TCGA−DY−A1DC−01 TCGA−DY−A0XA−01 TCGA−DT−5265−01 TCGA−DM−A28H−01 TCGA−DM−A28G−01 TCGA−DM−A28C−01 TCGA−DM−A285−01 TCGA−DM−A1HA−01 TCGA−DM−A1D8−01 TCGA−DC−6683−01 TCGA−DC−6160−01 TCGA−DC−6158−01 TCGA−DC−6157−01 TCGA−DC−5869−01 TCGA−D5−6931−01 TCGA−D5−6929−01 TCGA−D5−6926−01 TCGA−D5−6920−01 TCGA−D5−6541−01 TCGA−D5−6537−01 TCGA−D5−6534−01 TCGA−D5−6529−01 TCGA−D5−5539−01 TCGA−D5−5538−01 TCGA−CM−6680−01 TCGA−CM−6678−01 TCGA−CM−6676−01 TCGA−CM−6169−01 TCGA−CM−6168−01 TCGA−CM−4747−01 TCGA−CM−4743−01 TCGA−CL−5918−01 TCGA−CL−5917−01 TCGA−CK−6747−01 TCGA−CK−5912−01 TCGA−CI−6624−01 TCGA−CI−6619−01 TCGA−CA−6719−01 TCGA−AZ−6606−01 TCGA−AZ−6599−01 TCGA−AZ−5403−01 TCGA−AZ−4682−01 TCGA−AZ−4616−01 TCGA−AH−6644−01 TCGA−AH−6643−01 TCGA−AH−6544−01 TCGA−AG−A02N−01 TCGA−AG−A020−01 TCGA−AG−A00H−01 TCGA−AG−4015−01 TCGA−AG−3901−01 TCGA−AG−3887−01 TCGA−AG−3878−01 TCGA−AG−3742−01 TCGA−AG−3731−01 TCGA−AF−6672−01 TCGA−AF−2693−01 TCGA−AF−2687−01 TCGA−AD−6963−01 TCGA−AD−6899−01 TCGA−AD−6890−01 TCGA−AD−6548−01 TCGA−AA−A03J−01 TCGA−AA−A03F−01 TCGA−AA−A02Y−01 TCGA−AA−A02O−01 TCGA−AA−A01V−01 TCGA−AA−A01K−01 TCGA−AA−A01I−01 TCGA−AA−3956−01 TCGA−AA−3939−01 TCGA−AA−3866−01 TCGA−AA−3852−01 TCGA−AA−3850−01 TCGA−AA−3848−01 TCGA−AA−3837−01 TCGA−AA−3818−01 TCGA−AA−3815−01 TCGA−AA−3812−01 TCGA−AA−3696−01 TCGA−AA−3673−01 TCGA−AA−3655−01 TCGA−AA−3496−01 TCGA−A6−6782−01 TCGA−A6−6652−01 TCGA−A6−6649−01 TCGA−A6−6141−01 TCGA−A6−4105−01 TCGA−A6−3809−01 TCGA−A6−3808−01

TCGA−AG−3574−01 TCGA−AA−3562−01 TCGA−AA−3543−01 TCGA−AA−A01D−01 TCGA−A6−2672−01 TCGA−CM−5348−01 TCGA−AA−3525−01 TCGA−AA−A022−01 TCGA−AA−3518−01 TCGA−AA−3516−01 TCGA−AA−3949−01 TCGA−AG−3601−01 TCGA−AA−3811−01 TCGA−CK−5913−01 TCGA−AA−A01Q−01 TCGA−DM−A28F−01 TCGA−DY−A1DD−01 TCGA−CK−5915−01 TCGA−AG−A036−01 TCGA−D5−6533−01 TCGA−AZ−6603−01 TCGA−AA−3971−01 TCGA−AA−3845−01 TCGA−AA−3534−01 TCGA−A6−6781−01 TCGA−G4−6309−01 TCGA−AA−3664−01 TCGA−EI−6508−01 TCGA−CM−6167−01 TCGA−AH−6549−01 TCGA−AA−3833−01 TCGA−AA−3552−01 TCGA−AG−A002−01 TCGA−AA−3984−01 TCGA−AA−3672−01 TCGA−D5−6928−01 TCGA−D5−6922−01 TCGA−CM−6675−01 TCGA−CA−6715−01 TCGA−AY−6196−01 TCGA−CM−5868−01 TCGA−AZ−4323−01 TCGA−AA−3952−01 TCGA−DM−A1DA−01 TCGA−F5−6465−01 TCGA−AA−3666−01 TCGA−DC−5337−01 TCGA−CA−5797−01 TCGA−AG−A01L−01 TCGA−AG−3894−01 TCGA−AF−3913−01 TCGA−AA−A02F−01 TCGA−AA−A024−01 TCGA−AA−A00F−01 TCGA−AA−3976−01 TCGA−AA−3973−01 TCGA−AA−3972−01 TCGA−AA−3819−01 TCGA−AA−3549−01 TCGA−A6−2678−01 TCGA−CA−6717−01 TCGA−AA−A010−01 TCGA−G4−6588−01 TCGA−CM−6162−01 TCGA−AY−6197−01 TCGA−AA−3947−01 TCGA−G4−6628−01 TCGA−G4−6315−01 TCGA−G4−6307−01 TCGA−F4−6570−01 TCGA−F4−6460−01 TCGA−D5−6540−01 TCGA−AU−6004−01 TCGA−AA−3815−01 TCGA−AA−3662−01 TCGA−A6−6780−01 TCGA−G4−6310−01 TCGA−G4−6304−01 TCGA−G4−6303−01 TCGA−DC−6682−01 TCGA−CM−6171−01 TCGA−CM−6161−01 TCGA−CM−5349−01 TCGA−CK−6746−01 TCGA−CK−5916−01 TCGA−CK−5914−01 TCGA−AH−6643−01 TCGA−AF−6136−01 TCGA−AA−A01V−01 TCGA−AA−3712−01 TCGA−AA−3697−01 TCGA−AA−3510−01 TCGA−A6−3809−01 TCGA−G4−6299−01 TCGA−F5−6811−01 TCGA−F4−6459−01 TCGA−DY−A1DG−01 TCGA−DY−A1DC−01 TCGA−DY−A0XA−01 TCGA−DT−5265−01 TCGA−DM−A28C−01 TCGA−DM−A0XF−01 TCGA−D5−6534−01 TCGA−D5−5541−01 TCGA−CM−6680−01 TCGA−CM−6676−01 TCGA−CM−6172−01 TCGA−CM−5864−01 TCGA−CM−5861−01 TCGA−CM−5344−01 TCGA−CM−4752−01 TCGA−CK−6747−01 TCGA−CK−4952−01 TCGA−AZ−5403−01 TCGA−AU−3779−01 TCGA−AG−4015−01 TCGA−AF−2693−01 TCGA−AD−6963−01 TCGA−AD−5900−01 TCGA−AA−3950−01 TCGA−AA−3866−01 TCGA−AA−3850−01 TCGA−A6−5660−01 TCGA−A6−5656−01 TCGA−G4−6317−01 TCGA−G4−6293−01 TCGA−F5−6813−01 TCGA−F4−6809−01 TCGA−F4−6808−01 TCGA−F4−6569−01 TCGA−DC−6158−01 TCGA−DC−6157−01 TCGA−DC−5869−01 TCGA−D5−6929−01 TCGA−D5−6926−01 TCGA−D5−6923−01 TCGA−D5−6920−01 TCGA−D5−6898−01 TCGA−CM−6169−01 TCGA−CM−5860−01 TCGA−CL−5918−01 TCGA−CK−5912−01 TCGA−CI−6624−01 TCGA−CI−6619−01 TCGA−CA−6719−01 TCGA−AZ−4682−01 TCGA−AF−2687−01 TCGA−AD−6899−01 TCGA−AD−6890−01 TCGA−AA−3956−01 TCGA−AA−3877−01 TCGA−AA−3812−01 TCGA−AA−3496−01 TCGA−AA−3492−01 TCGA−AA−3489−01 TCGA−A6−6652−01 TCGA−A6−6649−01 TCGA−AZ−4315−01 TCGA−G4−6586−01 TCGA−AA−A00N−01 TCGA−CM−4746−01 TCGA−CA−6718−01 TCGA−AA−3713−01 TCGA−A6−5661−01 TCGA−DM−A1D9−01 TCGA−CK−4950−01 TCGA−AZ−6601−01 TCGA−AG−3892−01 TCGA−AD−6964−01 TCGA−AD−6895−01 TCGA−AA−3977−01 TCGA−AA−3864−01 TCGA−A6−5665−01 TCGA−EI−6507−01 TCGA−DM−A28H−01 TCGA−DM−A0X9−01 TCGA−D5−6927−01 TCGA−D5−6539−01 TCGA−D5−6538−01 TCGA−CM−5862−01 TCGA−AZ−6608−01 TCGA−AZ−6599−01 TCGA−AZ−6598−01 TCGA−AZ−5407−01 TCGA−AA−A01R−01 TCGA−AA−3660−01 TCGA−A6−5666−01 TCGA−G5−6235−01 TCGA−G4−6625−01 TCGA−F4−6856−01 TCGA−F4−6703−01 TCGA−EI−6510−01 TCGA−DM−A1HA−01 TCGA−DM−A1DB−01 TCGA−DM−A1D7−01 TCGA−DM−A0XD−01 TCGA−D5−7000−01 TCGA−D5−6930−01 TCGA−D5−6536−01 TCGA−D5−6532−01 TCGA−D5−5538−01 TCGA−CM−6674−01 TCGA−CM−6164−01 TCGA−CM−4743−01 TCGA−CK−4948−01 TCGA−CI−6622−01 TCGA−AY−6386−01 TCGA−AY−5543−01 TCGA−AG−A02N−01 TCGA−AF−2691−01 TCGA−AD−6889−01 TCGA−AA−3663−01 TCGA−AA−3655−01 TCGA−AA−3555−01 TCGA−AA−3511−01 TCGA−A6−6782−01 TCGA−A6−6654−01 TCGA−A6−6653−01 TCGA−A6−6141−01 TCGA−A6−5659−01 TCGA−G4−6626−01 TCGA−G4−6323−01 TCGA−G4−6306−01 TCGA−F5−6571−01 TCGA−F4−6855−01 TCGA−F4−6854−01 TCGA−F4−6807−01 TCGA−F4−6805−01 TCGA−EF−5830−01 TCGA−DY−A1H8−01 TCGA−DY−A1DF−01 TCGA−DM−A28G−01 TCGA−DM−A285−01 TCGA−DM−A282−01 TCGA−DM−A1D8−01 TCGA−DM−A1D4−01 TCGA−DC−6683−01 TCGA−DC−6160−01 TCGA−D5−6932−01 TCGA−D5−6931−01 TCGA−D5−6541−01 TCGA−D5−6537−01 TCGA−D5−6535−01 TCGA−D5−6529−01 TCGA−D5−5540−01 TCGA−D5−5539−01 TCGA−D5−5537−01 TCGA−CM−6678−01 TCGA−CM−6168−01 TCGA−CM−6166−01 TCGA−CM−4747−01 TCGA−CM−4744−01 TCGA−CL−5917−01 TCGA−CK−4947−01 TCGA−CA−6716−01 TCGA−AZ−6606−01 TCGA−AZ−4616−01 TCGA−AH−6644−01 TCGA−AH−6544−01 TCGA−AG−A025−01 TCGA−AG−A020−01 TCGA−AG−A00H−01 TCGA−AG−3901−01 TCGA−AG−3887−01 TCGA−AG−3878−01 TCGA−AG−3742−01 TCGA−AG−3731−01 TCGA−AG−3727−01 TCGA−AG−3726−01 TCGA−AF−6672−01 TCGA−AF−4110−01 TCGA−AD−6965−01 TCGA−AD−6548−01 TCGA−AA−A03J−01 TCGA−AA−A03F−01 TCGA−AA−A02Y−01 TCGA−AA−A02O−01 TCGA−AA−A01K−01 TCGA−AA−A01I−01 TCGA−AA−A00A−01 TCGA−AA−3979−01 TCGA−AA−3939−01 TCGA−AA−3852−01 TCGA−AA−3848−01 TCGA−AA−3837−01 TCGA−AA−3818−01 TCGA−AA−3715−01 TCGA−AA−3696−01 TCGA−AA−3695−01 TCGA−AA−3673−01 TCGA−AA−3558−01 TCGA−A6−5662−01 TCGA−A6−5657−01 TCGA−A6−4105−01 TCGA−A6−3808−01 TCGA−F5−6812−01 TCGA−F5−6702−01 TCGA−F4−6806−01 TCGA−EI−6506−01 TCGA−DM−A28K−01 TCGA−DM−A1D6−01 TCGA−DM−A1D0−01 TCGA−DC−6155−01 TCGA−CM−6163−01 TCGA−CM−5863−01 TCGA−CI−6620−01 TCGA−CA−5796−01 TCGA−AZ−6607−01 TCGA−AZ−6605−01 TCGA−AZ−6600−01 TCGA−AG−A032−01 TCGA−AG−A02X−01 TCGA−AG−A01W−01 TCGA−AG−A015−01 TCGA−AG−A014−01 TCGA−AG−A00Y−01 TCGA−AG−A00C−01 TCGA−AG−A008−01 TCGA−AG−4008−01 TCGA−AG−4005−01 TCGA−AG−3999−01 TCGA−AG−3909−01 TCGA−AG−3902−01 TCGA−AG−3896−01 TCGA−AG−3885−01 TCGA−AG−3611−01 TCGA−AG−3605−01 TCGA−AG−3602−01 TCGA−AG−3599−01 TCGA−AG−3594−01 TCGA−AG−3586−01 TCGA−AG−3583−01 TCGA−AG−3581−01 TCGA−AG−3580−01 TCGA−AG−3575−01 TCGA−AF−6655−01 TCGA−AF−5654−01 TCGA−AF−2692−01 TCGA−AF−2689−01 TCGA−AD−6901−01 TCGA−AA−A02W−01 TCGA−AA−A029−01 TCGA−AA−A01Z−01 TCGA−AA−A01X−01 TCGA−AA−A01G−01 TCGA−AA−A01F−01 TCGA−AA−A00Q−01 TCGA−AA−A00K−01 TCGA−AA−3994−01 TCGA−AA−3986−01 TCGA−AA−3975−01 TCGA−AA−3941−01 TCGA−AA−3930−01 TCGA−AA−3870−01 TCGA−AA−3854−01 TCGA−AA−3851−01 TCGA−AA−3844−01 TCGA−AA−3842−01 TCGA−AA−3814−01 TCGA−AA−3681−01 TCGA−AA−3680−01 TCGA−AA−3561−01 TCGA−AA−3560−01 TCGA−AA−3556−01 TCGA−AA−3548−01 TCGA−AA−3532−01 TCGA−AA−3530−01 TCGA−AA−3522−01 TCGA−AA−3521−01 TCGA−AA−3520−01 TCGA−AA−3502−01 TCGA−A6−6138−01 TCGA−A6−5664−01 TCGA−A6−2683−01

Regulation Of Gene Expression By Hypoxia Inducible Factor FDR = 4.9e−09%, FDR nod = 1.8% PTK6 Promotes HIF1A Stabilization FDR = 2e−12%, FDR nod = 2.6e−08%

CITED2 HBEGF


KRAS COL6A3

PIK3CA COL6A6

PIK3R1 COL6A5

TEK COL4A4

GRB14 COL4A1

PTPN11 PDGFRB

SHC1 PLG

ANGPT1 COL4A2

ANGPT2 PDGFD

ANGPT4 COL4A3

DOK2 PDGFC

GRB2 PLAT

GRB7 THBS3

HRAS COL9A2

PIK3CB THBS1

PIK3R2 COL9A3

SOS1 THBS4

FLT4

ITGB1

SHC1

SOS1

VEGFC

ITGA2

ITGA4

MAPK14

COL1A1

GRB2

MAPK1

MAPK3

PRRT2

CREB1

FIGF

ITGA1

RPS6KA1

wt AKT1 wt

wt wt

known HCG mut MAP2K4 known HCG mut


PIK3CA

FN1

PIK3R1

COL1A2

ITGA5

PIK3CA BRAF NRAS PIK3R1 PRKD1 PIK3C3 PIK3CG PRKCG PIK3C2B PRKCQ ETS1 PLCG2 ARAF CASP9 KDR PIK3C2A PLCG1 PRKCA PRKCE PRKCH AKT1 HIF1A MAPK1 MAPK14 NOS3 PIK3CB PIK3CD PIK3R3 PLA2G4A PRKCB PRKD3 RAF1 HRAS HSPB1 MAP2K1 MAP2K2 MAPK3 MAPKAPK2 MAPKAPK3 PIK3R2 PRKCD PRKCI PRKCZ PRKD2 PTK2 PXN RAC1 RAC2 RAC3 SH2D2A SHC2 SPHK1 SPHK2 VEGFA

TCGA−AG−3601−01 TCGA−AA−3543−01 TCGA−AD−6888−01 TCGA−AA−3518−01 TCGA−D5−6928−01 TCGA−AA−3982−01 TCGA−AA−3811−01 TCGA−D5−6533−01 TCGA−AA−A01Q−01 TCGA−DY−A1DD−01 TCGA−CM−6675−01 TCGA−CK−5915−01 TCGA−AA−3516−01 TCGA−CK−5913−01 TCGA−AA−3949−01 TCGA−CI−6621−01 TCGA−AA−3710−01 TCGA−DM−A28F−01 TCGA−AG−A036−01 TCGA−AY−6196−01 TCGA−AA−3989−01 TCGA−AA−3845−01 TCGA−A6−2676−01 TCGA−AG−A002−01 TCGA−AA−3984−01 TCGA−A6−6781−01 TCGA−G4−6309−01 TCGA−EI−6508−01 TCGA−D5−6922−01 TCGA−CM−6167−01 TCGA−AH−6549−01 TCGA−AA−3833−01 TCGA−AA−3664−01 TCGA−AA−3552−01 TCGA−DM−A1DA−01 TCGA−AG−A01L−01 TCGA−F5−6465−01 TCGA−DC−5337−01 TCGA−CA−5797−01 TCGA−AG−3894−01 TCGA−AF−3913−01 TCGA−AA−A02F−01 TCGA−AA−A024−01 TCGA−AA−A00F−01 TCGA−AA−3976−01 TCGA−AA−3973−01 TCGA−AA−3972−01 TCGA−AA−3819−01 TCGA−AA−3666−01 TCGA−AA−3549−01 TCGA−A6−2678−01 TCGA−G4−6315−01 TCGA−CA−6717−01 TCGA−AA−A010−01 TCGA−G4−6307−01 TCGA−F4−6570−01 TCGA−CM−6162−01 TCGA−AA−3947−01 TCGA−G4−6588−01 TCGA−DY−A1DC−01 TCGA−DC−6682−01 TCGA−D5−6540−01 TCGA−CM−6171−01 TCGA−CM−6161−01 TCGA−CK−5916−01 TCGA−CK−5914−01 TCGA−AF−6136−01 TCGA−AD−5900−01 TCGA−AA−3712−01 TCGA−AA−3697−01 TCGA−AA−3662−01 TCGA−A6−6780−01 TCGA−G4−6310−01 TCGA−G4−6304−01 TCGA−G4−6303−01 TCGA−G4−6299−01 TCGA−F5−6811−01 TCGA−F4−6460−01 TCGA−DY−A1DG−01 TCGA−DY−A0XA−01 TCGA−DC−6157−01 TCGA−D5−6534−01 TCGA−D5−5541−01 TCGA−CM−6680−01 TCGA−CM−6676−01 TCGA−CM−5864−01 TCGA−CM−5861−01 TCGA−CM−4752−01 TCGA−CK−6747−01 TCGA−CK−6746−01 TCGA−AY−6197−01 TCGA−AU−6004−01 TCGA−AU−3779−01 TCGA−AH−6643−01 TCGA−AG−4015−01 TCGA−AF−2693−01 TCGA−AA−A01V−01 TCGA−AA−3850−01 TCGA−AA−3510−01 TCGA−A6−5660−01 TCGA−A6−5656−01 TCGA−A6−3809−01 TCGA−G4−6628−01 TCGA−G4−6317−01 TCGA−G4−6293−01 TCGA−F5−6813−01 TCGA−F4−6809−01 TCGA−F4−6808−01 TCGA−F4−6569−01 TCGA−F4−6459−01 TCGA−DT−5265−01 TCGA−DM−A28C−01 TCGA−DM−A0XF−01 TCGA−DC−6158−01 TCGA−DC−5869−01 TCGA−D5−6929−01 TCGA−D5−6926−01 TCGA−D5−6923−01 TCGA−D5−6920−01 TCGA−D5−6898−01 TCGA−CM−6172−01 TCGA−CM−6169−01 TCGA−CM−5860−01 TCGA−CM−5349−01 TCGA−CM−5344−01 TCGA−CL−5918−01 TCGA−CK−5912−01 TCGA−CK−4952−01 TCGA−CI−6624−01 TCGA−CI−6619−01 TCGA−CA−6719−01 TCGA−AZ−5403−01 TCGA−AZ−4682−01 TCGA−AF−2687−01 TCGA−AD−6963−01 TCGA−AD−6899−01 TCGA−AD−6890−01 TCGA−AA−3956−01 TCGA−AA−3950−01 TCGA−AA−3877−01 TCGA−AA−3866−01 TCGA−AA−3815−01 TCGA−AA−3812−01 TCGA−AA−3496−01 TCGA−AA−3492−01 TCGA−AA−3489−01 TCGA−A6−6652−01 TCGA−A6−6649−01 TCGA−AZ−4315−01 TCGA−G4−6586−01 TCGA−D5−6536−01 TCGA−CA−6718−01 TCGA−AZ−6598−01 TCGA−AA−A00N−01 TCGA−AA−3713−01 TCGA−DM−A1D9−01 TCGA−D5−6538−01 TCGA−CM−5862−01 TCGA−CK−4948−01 TCGA−AZ−6608−01 TCGA−AZ−6601−01 TCGA−AZ−6599−01 TCGA−AG−3892−01 TCGA−AD−6964−01 TCGA−AD−6889−01 TCGA−AA−3977−01 TCGA−AA−3864−01 TCGA−AA−3715−01 TCGA−AA−3660−01 TCGA−AA−3655−01 TCGA−A6−5661−01 TCGA−G4−6625−01 TCGA−F5−6571−01 TCGA−F4−6856−01 TCGA−EI−6507−01 TCGA−DM−A1HA−01 TCGA−DM−A1DB−01 TCGA−DM−A0XD−01 TCGA−DM−A0X9−01 TCGA−D5−6927−01 TCGA−D5−6537−01 TCGA−D5−6532−01 TCGA−D5−6529−01 TCGA−D5−5538−01 TCGA−CM−6674−01 TCGA−CM−6164−01 TCGA−CM−4746−01 TCGA−CM−4743−01 TCGA−CL−5917−01 TCGA−CK−4950−01 TCGA−CI−6622−01 TCGA−AY−5543−01 TCGA−AD−6895−01 TCGA−AA−A01K−01 TCGA−AA−3555−01 TCGA−AA−3511−01 TCGA−A6−6782−01 TCGA−A6−5666−01 TCGA−A6−5665−01 TCGA−A6−5659−01 TCGA−A6−5657−01 TCGA−G5−6235−01 TCGA−G4−6626−01 TCGA−G4−6323−01 TCGA−G4−6306−01 TCGA−F4−6855−01 TCGA−F4−6854−01 TCGA−F4−6807−01 TCGA−F4−6805−01 TCGA−F4−6703−01 TCGA−EI−6510−01 TCGA−EF−5830−01 TCGA−DY−A1H8−01 TCGA−DY−A1DF−01 TCGA−DM−A28H−01 TCGA−DM−A28G−01 TCGA−DM−A285−01 TCGA−DM−A1D8−01 TCGA−DM−A1D7−01 TCGA−DM−A1D6−01 TCGA−DM−A1D4−01 TCGA−DC−6683−01 TCGA−DC−6160−01 TCGA−D5−7000−01 TCGA−D5−6932−01 TCGA−D5−6931−01 TCGA−D5−6930−01 TCGA−D5−6541−01 TCGA−D5−6539−01 TCGA−D5−6535−01 TCGA−D5−5540−01 TCGA−D5−5539−01 TCGA−CM−6678−01 TCGA−CM−6168−01 TCGA−CM−6166−01 TCGA−CM−6163−01 TCGA−CM−4747−01 TCGA−CK−4947−01 TCGA−AZ−6606−01 TCGA−AZ−5407−01 TCGA−AZ−4616−01 TCGA−AY−6386−01 TCGA−AH−6644−01 TCGA−AH−6544−01 TCGA−AG−A02N−01 TCGA−AG−A025−01 TCGA−AG−A020−01 TCGA−AG−A00H−01 TCGA−AG−4005−01 TCGA−AG−3901−01 TCGA−AG−3887−01 TCGA−AG−3878−01 TCGA−AG−3742−01 TCGA−AG−3731−01 TCGA−AG−3726−01 TCGA−AF−6672−01 TCGA−AF−4110−01 TCGA−AF−2691−01 TCGA−AD−6965−01 TCGA−AD−6548−01 TCGA−AA−A03J−01 TCGA−AA−A03F−01 TCGA−AA−A02Y−01 TCGA−AA−A02O−01 TCGA−AA−A01I−01 TCGA−AA−A00Q−01 TCGA−AA−A00A−01 TCGA−AA−3979−01 TCGA−AA−3939−01 TCGA−AA−3852−01 TCGA−AA−3848−01 TCGA−AA−3837−01 TCGA−AA−3818−01 TCGA−AA−3696−01 TCGA−AA−3695−01 TCGA−AA−3673−01 TCGA−AA−3663−01 TCGA−AA−3558−01 TCGA−A6−6654−01 TCGA−A6−6141−01 TCGA−A6−5662−01 TCGA−A6−4105−01 TCGA−A6−3808−01 TCGA−F5−6812−01 TCGA−F5−6702−01 TCGA−F4−6806−01 TCGA−EI−6506−01 TCGA−DM−A28K−01 TCGA−DM−A282−01 TCGA−DM−A1D0−01 TCGA−DC−6155−01 TCGA−D5−5537−01 TCGA−CM−5863−01 TCGA−CM−4744−01 TCGA−CI−6620−01 TCGA−CA−6716−01 TCGA−CA−5796−01 TCGA−AZ−6607−01 TCGA−AZ−6605−01 TCGA−AZ−6600−01 TCGA−AG−A032−01 TCGA−AG−A02X−01 TCGA−AG−A01W−01 TCGA−AG−A015−01 TCGA−AG−A014−01 TCGA−AG−A00Y−01 TCGA−AG−A00C−01 TCGA−AG−A008−01 TCGA−AG−4008−01 TCGA−AG−3999−01 TCGA−AG−3909−01 TCGA−AG−3902−01 TCGA−AG−3896−01 TCGA−AG−3885−01 TCGA−AG−3727−01 TCGA−AG−3611−01 TCGA−AG−3605−01 TCGA−AG−3602−01 TCGA−AG−3599−01 TCGA−AG−3594−01 TCGA−AG−3586−01 TCGA−AG−3583−01 TCGA−AG−3581−01 TCGA−AG−3580−01 TCGA−AG−3575−01 TCGA−AF−6655−01 TCGA−AF−5654−01 TCGA−AF−2692−01 TCGA−AF−2689−01 TCGA−AD−6901−01 TCGA−AA−A02W−01 TCGA−AA−A029−01 TCGA−AA−A01Z−01 TCGA−AA−A01X−01 TCGA−AA−A01R−01 TCGA−AA−A01G−01 TCGA−AA−A01F−01 TCGA−AA−A00K−01 TCGA−AA−3994−01 TCGA−AA−3986−01 TCGA−AA−3975−01 TCGA−AA−3941−01 TCGA−AA−3930−01 TCGA−AA−3870−01 TCGA−AA−3854−01 TCGA−AA−3851−01 TCGA−AA−3844−01 TCGA−AA−3842−01 TCGA−AA−3814−01 TCGA−AA−3681−01 TCGA−AA−3680−01 TCGA−AA−3561−01 TCGA−AA−3560−01 TCGA−AA−3556−01 TCGA−AA−3548−01 TCGA−AA−3532−01 TCGA−AA−3530−01 TCGA−AA−3522−01 TCGA−AA−3521−01 TCGA−AA−3520−01 TCGA−AA−3502−01 TCGA−A6−6653−01 TCGA−A6−6138−01 TCGA−A6−5664−01 TCGA−A6−2683−01

TCGA−F5−6571−01 TCGA−AG−A02G−01 TCGA−AH−6643−01 TCGA−AG−A014−01 TCGA−G4−6626−01 TCGA−AG−A011−01 TCGA−D5−6529−01 TCGA−AA−3844−01 TCGA−G4−6321−01 TCGA−AA−3697−01 TCGA−G4−6306−01 TCGA−AD−6963−01 TCGA−AU−6004−01 TCGA−AA−3489−01 TCGA−DT−5265−01 TCGA−AA−3496−01 TCGA−D5−6540−01 TCGA−D5−6931−01 TCGA−AA−3877−01 TCGA−G4−6323−01 TCGA−CM−6161−01 TCGA−AG−3883−01 TCGA−AG−A02N−01 TCGA−G4−6315−01 TCGA−AA−3852−01 TCGA−DY−A1DG−01 TCGA−AG−4005−01 TCGA−AD−6899−01 TCGA−AA−3543−01 TCGA−AA−3525−01 TCGA−DM−A28G−01 TCGA−AD−6901−01 TCGA−AA−A024−01 TCGA−AA−3939−01 TCGA−D5−6927−01 TCGA−AA−3534−01 TCGA−AA−3971−01 TCGA−AA−3866−01 TCGA−AA−3713−01 TCGA−A6−6654−01 TCGA−A6−2672−01 TCGA−D5−6532−01 TCGA−AG−3887−01 TCGA−AA−3989−01 TCGA−AA−3930−01 TCGA−AA−3531−01 TCGA−EI−6507−01 TCGA−D5−6541−01 TCGA−CM−5348−01 TCGA−G4−6304−01 TCGA−EI−6508−01 TCGA−EF−5830−01 TCGA−D5−6534−01 TCGA−CM−6679−01 TCGA−CM−4746−01 TCGA−AA−A02K−01 TCGA−A6−6782−01 TCGA−CM−4752−01 TCGA−AA−A02J−01 TCGA−AA−3968−01 TCGA−AA−3966−01 TCGA−AA−3695−01 TCGA−A6−5664−01 TCGA−D5−6930−01 TCGA−G4−6588−01 TCGA−CK−6746−01 TCGA−F4−6805−01 TCGA−CM−6168−01 TCGA−CM−5864−01 TCGA−F5−6812−01 TCGA−DM−A1D0−01 TCGA−D5−6924−01 TCGA−CM−6676−01 TCGA−CM−6164−01 TCGA−AU−3779−01 TCGA−AA−3955−01 TCGA−AA−3710−01 TCGA−F4−6569−01 TCGA−DM−A0X9−01 TCGA−D5−6537−01 TCGA−CM−6166−01 TCGA−AA−3950−01 TCGA−AA−3848−01 TCGA−G4−6307−01 TCGA−DY−A1H8−01 TCGA−D5−5538−01 TCGA−AG−3896−01 TCGA−AD−6964−01 TCGA−AA−A01P−01 TCGA−AA−3696−01 TCGA−AA−3519−01 TCGA−CK−5916−01 TCGA−AA−3815−01 TCGA−AA−3811−01 TCGA−AD−5900−01 TCGA−G4−6303−01 TCGA−DY−A1DD−01 TCGA−DM−A1HA−01 TCGA−CM−6165−01 TCGA−AY−4070−01 TCGA−AG−A036−01 TCGA−AG−A025−01 TCGA−AF−4110−01 TCGA−AD−6965−01 TCGA−AA−A00F−01 TCGA−AA−3842−01 TCGA−AA−3680−01 TCGA−AA−3542−01 TCGA−AZ−6598−01 TCGA−CA−6718−01 TCGA−AA−3663−01 TCGA−AA−3492−01 TCGA−D5−6535−01 TCGA−A6−5661−01 TCGA−G4−6628−01 TCGA−D5−6533−01 TCGA−CM−5861−01 TCGA−A6−6780−01 TCGA−A6−3809−01 TCGA−D5−6923−01 TCGA−AF−3913−01 TCGA−AA−3712−01 TCGA−AA−3530−01 TCGA−F5−6813−01 TCGA−DY−A1DC−01 TCGA−CK−5914−01 TCGA−AG−3731−01 TCGA−AD−6548−01 TCGA−AA−A029−01 TCGA−AA−A022−01 TCGA−AA−3986−01 TCGA−AA−3861−01 TCGA−AA−3814−01 TCGA−A6−5662−01 TCGA−A6−3808−01 TCGA−AA−3864−01 TCGA−F4−6570−01 TCGA−F4−6460−01 TCGA−AD−6895−01 TCGA−AA−3510−01 TCGA−DM−A1DA−01 TCGA−DM−A1D9−01 TCGA−CM−6675−01 TCGA−CA−6715−01 TCGA−AY−6197−01 TCGA−AY−6196−01 TCGA−AA−3947−01 TCGA−AA−3672−01 TCGA−F5−6465−01 TCGA−EI−6510−01 TCGA−DM−A282−01 TCGA−DM−A1D7−01 TCGA−DM−A1D4−01 TCGA−DM−A0XF−01 TCGA−D5−7000−01 TCGA−D5−6539−01 TCGA−CM−5349−01 TCGA−CM−5344−01 TCGA−CK−4950−01 TCGA−AZ−5407−01 TCGA−AZ−4323−01 TCGA−A6−5666−01 TCGA−A6−5659−01 TCGA−G5−6235−01 TCGA−G4−6310−01 TCGA−F4−6459−01 TCGA−D5−6922−01 TCGA−CM−6172−01 TCGA−CM−5868−01 TCGA−CA−6716−01 TCGA−AA−3952−01 TCGA−AA−3666−01 TCGA−AA−3662−01 TCGA−AA−3660−01 TCGA−AG−A002−01 TCGA−CA−6717−01 TCGA−AA−3984−01 TCGA−AA−A010−01 TCGA−AZ−4315−01 TCGA−AD−6889−01 TCGA−A6−5665−01 TCGA−AA−A00N−01 TCGA−AA−3977−01 TCGA−D5−6928−01 TCGA−AZ−6601−01 TCGA−AA−3715−01 TCGA−A6−6653−01 TCGA−AA−A01R−01 TCGA−A6−6781−01 TCGA−A6−6141−01 TCGA−G4−6586−01 TCGA−F4−6856−01 TCGA−CM−4743−01 TCGA−AA−3516−01 TCGA−G4−6309−01 TCGA−DM−A28F−01 TCGA−CM−6674−01 TCGA−AZ−6608−01 TCGA−AA−A01D−01 TCGA−AA−3949−01 TCGA−D5−5537−01 TCGA−CM−6171−01 TCGA−CL−5917−01 TCGA−CI−6624−01 TCGA−AZ−6603−01 TCGA−AY−6386−01 TCGA−AG−3892−01 TCGA−AG−3885−01 TCGA−AG−3605−01 TCGA−AA−3845−01 TCGA−AA−3555−01 TCGA−AA−3554−01 TCGA−A6−6649−01 TCGA−F4−6703−01 TCGA−DM−A28E−01 TCGA−D5−6929−01 TCGA−D5−6920−01 TCGA−D5−5539−01 TCGA−CM−6167−01 TCGA−CK−4947−01 TCGA−CI−6620−01 TCGA−AG−A026−01 TCGA−AG−A01L−01 TCGA−AF−2693−01 TCGA−AF−2687−01 TCGA−AA−A01Q−01 TCGA−AA−A00L−01 TCGA−AA−3973−01 TCGA−AA−3850−01 TCGA−AA−3833−01 TCGA−AA−3681−01 TCGA−AA−3522−01 TCGA−A6−3807−01 TCGA−A6−2677−01

VEGFR3 Signaling In Lymphatic Endothelium FDR = 1.9e−12%, FDR nod = 1.2% VEGF Signaling Pathway FDR = 1.9e−12%, FDR nod = 0.053%

wt wt COL6A2

CA9 LRRK2

known HCG mut EP300 known HCG mut

known HCG mut NRAS known HCG mut THBS2

TCGA−F4−6809−01 TCGA−AY−6197−01 TCGA−AA−3977−01 TCGA−AG−3583−01 TCGA−AA−3975−01 TCGA−AA−3710−01 TCGA−CM−4746−01 TCGA−AA−A00L−01 TCGA−AA−A00A−01 TCGA−AA−3949−01 TCGA−AA−3663−01 TCGA−AZ−6606−01 TCGA−A6−2676−01 TCGA−AZ−6598−01 TCGA−CM−6674−01 TCGA−CK−5916−01 TCGA−CA−6718−01 TCGA−AA−A02K−01 TCGA−AA−3950−01 TCGA−A6−3809−01 TCGA−G4−6317−01 TCGA−F4−6704−01 TCGA−D5−6930−01 TCGA−D5−6922−01 TCGA−AZ−6600−01 TCGA−AA−3854−01 TCGA−AA−3848−01 TCGA−CK−5913−01 TCGA−CA−5796−01 TCGA−AD−6889−01 TCGA−AA−A00N−01 TCGA−A6−6653−01 TCGA−G5−6641−01 TCGA−G5−6235−01 TCGA−G4−6323−01 TCGA−F5−6813−01 TCGA−DM−A1D0−01 TCGA−DC−6682−01 TCGA−D5−6931−01 TCGA−D5−6539−01 TCGA−D5−5540−01 TCGA−CM−6162−01 TCGA−CM−5868−01 TCGA−CM−4752−01 TCGA−CI−6619−01 TCGA−AY−6386−01 TCGA−AG−3732−01 TCGA−AF−2687−01 TCGA−AA−A01G−01 TCGA−AA−A00R−01 TCGA−AA−A00J−01 TCGA−AA−3655−01 TCGA−AA−3555−01 TCGA−AA−3554−01 TCGA−AA−3527−01 TCGA−A6−6781−01 TCGA−A6−6780−01 TCGA−A6−6141−01 TCGA−A6−5659−01 TCGA−CA−6717−01 TCGA−G4−6628−01 TCGA−CM−4743−01 TCGA−AG−A002−01 TCGA−AA−A010−01 TCGA−AU−6004−01 TCGA−AA−3877−01 TCGA−AA−3864−01 TCGA−AA−3672−01 TCGA−G4−6588−01 TCGA−EI−6510−01 TCGA−EI−6507−01 TCGA−DM−A1DA−01 TCGA−CM−5861−01 TCGA−CM−5349−01 TCGA−AZ−6601−01 TCGA−AZ−4315−01 TCGA−AD−6964−01 TCGA−AD−5900−01 TCGA−AA−A022−01 TCGA−AA−A00E−01 TCGA−AA−3815−01 TCGA−AA−3715−01 TCGA−AA−3662−01 TCGA−G4−6625−01 TCGA−G4−6586−01 TCGA−G4−6307−01 TCGA−G4−6304−01 TCGA−G4−6293−01 TCGA−F5−6812−01 TCGA−F4−6808−01 TCGA−F4−6460−01 TCGA−DM−A28H−01 TCGA−DM−A1HA−01 TCGA−DM−A1D8−01 TCGA−DM−A1D7−01 TCGA−D5−6923−01 TCGA−D5−6540−01 TCGA−D5−6535−01 TCGA−D5−5538−01 TCGA−D5−5537−01 TCGA−CM−6680−01 TCGA−CM−6171−01 TCGA−CM−6168−01 TCGA−CM−6164−01 TCGA−CM−5344−01 TCGA−CK−6746−01 TCGA−CK−4948−01 TCGA−CI−6620−01 TCGA−AZ−6599−01 TCGA−AY−5543−01 TCGA−AU−3779−01 TCGA−AH−6643−01 TCGA−AH−6549−01 TCGA−AH−6544−01 TCGA−AG−A02N−01 TCGA−AG−3731−01 TCGA−AD−6963−01 TCGA−AA−A029−01 TCGA−AA−3984−01 TCGA−AA−3973−01 TCGA−AA−3966−01 TCGA−AA−3947−01 TCGA−AA−3818−01 TCGA−AA−3811−01 TCGA−AA−3713−01 TCGA−AA−3518−01 TCGA−AA−3516−01 TCGA−AA−3510−01 TCGA−A6−5665−01

TCGA−G4−6628−01 TCGA−CM−6674−01 TCGA−CK−5916−01 TCGA−AA−3950−01 TCGA−DM−A28H−01 TCGA−CK−6746−01 TCGA−AA−3977−01 TCGA−AA−3672−01 TCGA−AA−3496−01 TCGA−CA−6718−01 TCGA−CM−5868−01 TCGA−AZ−4315−01 TCGA−AA−A010−01 TCGA−AA−3492−01 TCGA−G5−6235−01 TCGA−G4−6625−01 TCGA−G4−6309−01 TCGA−F5−6571−01 TCGA−EI−6507−01 TCGA−DY−A1DC−01 TCGA−DT−5265−01 TCGA−DM−A28G−01 TCGA−DM−A282−01 TCGA−DM−A1D6−01 TCGA−D5−7000−01 TCGA−D5−6930−01 TCGA−D5−6924−01 TCGA−D5−6540−01 TCGA−CM−6679−01 TCGA−CM−6171−01 TCGA−CM−4744−01 TCGA−CK−5913−01 TCGA−CK−4952−01 TCGA−CA−6716−01 TCGA−AG−A02N−01 TCGA−AG−3882−01 TCGA−AG−3600−01 TCGA−AG−3578−01 TCGA−AD−6889−01 TCGA−AA−A022−01 TCGA−AA−A01Q−01 TCGA−AA−A01P−01 TCGA−AA−A00J−01 TCGA−AA−3984−01 TCGA−AA−3947−01 TCGA−AA−3939−01 TCGA−AA−3815−01 TCGA−AA−3713−01 TCGA−AA−3695−01 TCGA−AA−3680−01 TCGA−AA−3555−01 TCGA−AA−3510−01 TCGA−A6−6653−01 TCGA−A6−6648−01 TCGA−A6−6137−01 TCGA−A6−5662−01 TCGA−A6−5659−01 TCGA−CA−6717−01 TCGA−AZ−6601−01 TCGA−AZ−6598−01 TCGA−AG−A002−01 TCGA−G4−6588−01 TCGA−DY−A1DG−01 TCGA−DM−A1DB−01 TCGA−D5−6898−01 TCGA−D5−6538−01 TCGA−D5−6536−01 TCGA−CM−6162−01 TCGA−AZ−6599−01 TCGA−AD−6964−01 TCGA−AD−5900−01 TCGA−AA−A02K−01 TCGA−AA−A00N−01 TCGA−AA−A00E−01 TCGA−AA−3966−01 TCGA−AA−3811−01 TCGA−AA−3712−01 TCGA−A6−3809−01 TCGA−G4−6317−01 TCGA−G4−6315−01 TCGA−G4−6307−01 TCGA−G4−6306−01 TCGA−G4−6303−01 TCGA−G4−6299−01 TCGA−F5−6465−01 TCGA−F4−6809−01 TCGA−F4−6808−01 TCGA−F4−6460−01 TCGA−EF−5830−01 TCGA−DY−A1DF−01 TCGA−DY−A1DD−01 TCGA−DY−A0XA−01 TCGA−DM−A28F−01 TCGA−DM−A285−01 TCGA−DM−A1D8−01 TCGA−D5−6928−01 TCGA−D5−6920−01 TCGA−D5−6539−01 TCGA−D5−6537−01 TCGA−D5−6534−01 TCGA−D5−6533−01 TCGA−D5−5540−01 TCGA−D5−5539−01 TCGA−CM−6680−01 TCGA−CM−6677−01 TCGA−CM−6676−01 TCGA−CM−6170−01 TCGA−CM−6169−01 TCGA−CM−6168−01 TCGA−CM−6166−01 TCGA−CM−5862−01 TCGA−CM−5860−01 TCGA−CM−5344−01 TCGA−CK−6751−01 TCGA−CK−6748−01 TCGA−CK−5915−01 TCGA−CK−5914−01 TCGA−AZ−6603−01 TCGA−AZ−6600−01 TCGA−AZ−5407−01 TCGA−AZ−5403−01 TCGA−AY−6196−01 TCGA−AY−5543−01 TCGA−AU−6004−01 TCGA−AU−3779−01 TCGA−AG−3742−01 TCGA−AF−2687−01 TCGA−AD−6901−01 TCGA−AA−A01R−01 TCGA−AA−A00R−01 TCGA−AA−3982−01 TCGA−AA−3968−01 TCGA−AA−3697−01 TCGA−AA−3663−01 TCGA−AA−3542−01 TCGA−AA−3518−01 TCGA−AA−3502−01 TCGA−A6−5660−01

Tie2 Signaling FDR = 1.9e−12%, FDR nod = 0.074% Signaling By PDGF FDR = 1.9e−12%, FDR nod = 2.3e−11%


EGFR

CREBBP

HIF1A

GPNMB

HIF3A

HIF1A

ARNT

EPAS1

PTK6

EPO

VEGFA

PDGFRA

COL4A5

COL9A1

FURIN

COL6A1

SPP1

PDGFB

PDGFA

TCGA−A6−5664−01 TCGA−G4−6306−01 TCGA−AG−A032−01 TCGA−AA−3870−01 TCGA−AA−3543−01 TCGA−AA−A00Q−01 TCGA−CK−5915−01 TCGA−AZ−6607−01 TCGA−DY−A1DD−01 TCGA−CM−5341−01 TCGA−DM−A28K−01 TCGA−AA−3688−01 TCGA−DM−A28F−01 TCGA−AG−A01L−01 TCGA−AA−3842−01 TCGA−F4−6703−01 TCGA−AG−3601−01 TCGA−AA−3949−01 TCGA−D5−6533−01 TCGA−AA−A01Q−01 TCGA−AA−3979−01 TCGA−CM−6170−01 TCGA−AA−3976−01 TCGA−AA−3710−01 TCGA−CA−5796−01 TCGA−AA−3821−01 TCGA−CM−5348−01 TCGA−AG−3578−01 TCGA−AA−3516−01 TCGA−AD−6889−01 TCGA−D5−5537−01 TCGA−AZ−6605−01 TCGA−CM−5863−01 TCGA−CA−6715−01 TCGA−AA−A02J−01 TCGA−AA−A00R−01 TCGA−AA−3872−01 TCGA−AA−A00J−01 TCGA−AA−A00E−01 TCGA−DM−A28E−01 TCGA−DM−A1D0−01 TCGA−AA−3994−01 TCGA−AA−3555−01 TCGA−AA−3554−01 TCGA−AA−3524−01 TCGA−A6−6137−01 TCGA−A6−2672−01 TCGA−AA−3966−01 TCGA−DM−A1DA−01 TCGA−DC−5337−01 TCGA−AA−3952−01 TCGA−D5−6539−01 TCGA−D5−6535−01 TCGA−CA−6716−01 TCGA−AY−6196−01 TCGA−AG−A00Y−01 TCGA−AG−3727−01 TCGA−AA−3986−01 TCGA−AA−3861−01 TCGA−AA−3814−01 TCGA−AA−3672−01 TCGA−AG−3892−01 TCGA−AA−3984−01 TCGA−A6−6781−01 TCGA−G4−6626−01 TCGA−AD−6895−01 TCGA−G4−6309−01 TCGA−EI−6508−01 TCGA−D5−6922−01 TCGA−CM−6167−01 TCGA−AH−6549−01 TCGA−AG−A025−01 TCGA−AG−3726−01 TCGA−AA−3833−01 TCGA−AA−3664−01 TCGA−AA−3552−01 TCGA−AG−A002−01 TCGA−D5−6930−01 TCGA−CK−5913−01 TCGA−AA−3811−01 TCGA−F5−6812−01 TCGA−D5−6928−01 TCGA−AG−4005−01 TCGA−AD−6901−01 TCGA−AA−A01R−01 TCGA−AA−3845−01 TCGA−CM−6165−01 TCGA−AG−3593−01 TCGA−AA−A01D−01 TCGA−AA−3989−01 TCGA−AA−3972−01 TCGA−AA−3518−01 TCGA−AA−3502−01 TCGA−A6−3810−01 TCGA−A6−2676−01 TCGA−AA−A010−01 TCGA−AA−A00N−01 TCGA−CA−6717−01 TCGA−AZ−4315−01 TCGA−AY−6197−01 TCGA−AZ−6598−01 TCGA−AA−3715−01 TCGA−G4−6588−01 TCGA−G4−6586−01 TCGA−CM−6171−01 TCGA−CK−5916−01 TCGA−CK−4948−01 TCGA−CA−6718−01 TCGA−AZ−6601−01 TCGA−AD−6964−01 TCGA−AA−3864−01 TCGA−AA−3663−01 TCGA−AA−3510−01 TCGA−AA−3492−01 TCGA−A6−6780−01 TCGA−A6−6141−01 TCGA−A6−5665−01 TCGA−D5−6540−01 TCGA−CM−6162−01 TCGA−CM−4746−01 TCGA−AU−6004−01 TCGA−AD−5900−01 TCGA−AA−3977−01 TCGA−AA−3877−01 TCGA−A6−5661−01 TCGA−G4−6315−01 TCGA−EI−6507−01 TCGA−DC−6682−01 TCGA−D5−6927−01 TCGA−CM−6674−01 TCGA−CM−5861−01 TCGA−CM−5860−01 TCGA−CK−6746−01 TCGA−CK−5914−01 TCGA−AU−3779−01 TCGA−AF−6136−01 TCGA−AA−3950−01 TCGA−AA−3947−01 TCGA−AA−3818−01 TCGA−AA−3713−01 TCGA−AA−3662−01 TCGA−AA−3511−01 TCGA−A6−5666−01 TCGA−G4−6628−01 TCGA−G4−6625−01 TCGA−G4−6307−01 TCGA−G4−6304−01 TCGA−G4−6303−01 TCGA−G4−6293−01 TCGA−F5−6811−01 TCGA−F5−6571−01 TCGA−F4−6807−01 TCGA−F4−6570−01 TCGA−F4−6460−01 TCGA−DY−A1DG−01 TCGA−DM−A1DB−01 TCGA−DM−A1D9−01 TCGA−DM−A0XD−01 TCGA−DM−A0X9−01 TCGA−D5−6541−01 TCGA−D5−6538−01 TCGA−D5−6536−01 TCGA−D5−6534−01 TCGA−D5−6532−01 TCGA−D5−6529−01 TCGA−D5−5541−01 TCGA−CM−6172−01 TCGA−CM−6166−01 TCGA−CM−6164−01 TCGA−CM−6161−01 TCGA−CM−5864−01 TCGA−CM−5862−01 TCGA−CM−5349−01 TCGA−CM−4752−01 TCGA−CM−4743−01 TCGA−CK−4952−01 TCGA−CK−4950−01 TCGA−CK−4947−01 TCGA−CI−6624−01 TCGA−CI−6622−01 TCGA−CA−6719−01 TCGA−AZ−6608−01 TCGA−AZ−5407−01 TCGA−AY−5543−01 TCGA−AG−3742−01 TCGA−AD−6899−01 TCGA−AD−6548−01 TCGA−AA−3956−01 TCGA−AA−3852−01 TCGA−AA−3837−01 TCGA−AA−3712−01 TCGA−AA−3697−01 TCGA−AA−3660−01 TCGA−AA−3496−01 TCGA−A6−5660−01 TCGA−A6−5656−01 TCGA−A6−4105−01 TCGA−A6−3809−01 TCGA−A6−3808−01 TCGA−G5−6235−01 TCGA−G4−6323−01 TCGA−G4−6317−01 TCGA−G4−6310−01 TCGA−G4−6299−01 TCGA−F5−6813−01 TCGA−F4−6856−01 TCGA−F4−6855−01 TCGA−F4−6854−01 TCGA−F4−6809−01 TCGA−F4−6808−01 TCGA−F4−6805−01 TCGA−F4−6569−01 TCGA−F4−6459−01 TCGA−EF−5830−01 TCGA−DY−A1DC−01 TCGA−DY−A0XA−01 TCGA−DT−5265−01 TCGA−DM−A28H−01 TCGA−DM−A28G−01 TCGA−DM−A28C−01 TCGA−DM−A285−01 TCGA−DM−A1HA−01 TCGA−DM−A1D8−01 TCGA−DM−A1D7−01 TCGA−DM−A0XF−01 TCGA−DC−6683−01 TCGA−DC−6160−01 TCGA−DC−6158−01 TCGA−DC−6157−01 TCGA−DC−5869−01 TCGA−D5−7000−01 TCGA−D5−6931−01 TCGA−D5−6929−01 TCGA−D5−6926−01 TCGA−D5−6923−01 TCGA−D5−6920−01 TCGA−D5−6898−01 TCGA−D5−6537−01 TCGA−D5−5540−01 TCGA−D5−5539−01 TCGA−D5−5538−01 TCGA−CM−6680−01 TCGA−CM−6678−01 TCGA−CM−6676−01 TCGA−CM−6169−01 TCGA−CM−6168−01 TCGA−CM−5344−01 TCGA−CM−4747−01 TCGA−CL−5918−01 TCGA−CL−5917−01 TCGA−CK−6747−01 TCGA−CK−5912−01 TCGA−CI−6619−01 TCGA−AZ−6606−01 TCGA−AZ−6599−01 TCGA−AZ−5403−01 TCGA−AZ−4682−01 TCGA−AZ−4616−01 TCGA−AY−6386−01 TCGA−AH−6644−01 TCGA−AH−6643−01 TCGA−AH−6544−01 TCGA−AG−A02N−01 TCGA−AG−A020−01 TCGA−AG−A00H−01 TCGA−AG−4015−01 TCGA−AG−3901−01 TCGA−AG−3887−01 TCGA−AG−3878−01 TCGA−AG−3731−01 TCGA−AF−6672−01 TCGA−AF−2693−01 TCGA−AF−2687−01 TCGA−AD−6965−01 TCGA−AD−6963−01 TCGA−AD−6890−01 TCGA−AA−A03J−01 TCGA−AA−A03F−01 TCGA−AA−A02Y−01 TCGA−AA−A02O−01 TCGA−AA−A01V−01 TCGA−AA−A01K−01 TCGA−AA−A01I−01 TCGA−AA−3939−01 TCGA−AA−3866−01 TCGA−AA−3850−01 TCGA−AA−3848−01 TCGA−AA−3815−01 TCGA−AA−3812−01 TCGA−AA−3696−01 TCGA−AA−3673−01 TCGA−AA−3655−01 TCGA−AA−3489−01 TCGA−A6−6782−01 TCGA−A6−6654−01 TCGA−A6−6652−01 TCGA−A6−6649−01 TCGA−A6−5662−01 TCGA−A6−5659−01 TCGA−A6−5657−01

TCGA−AG−3727−01 TCGA−AA−3562−01 TCGA−AA−A01Z−01 TCGA−AA−3527−01 TCGA−CM−6165−01 TCGA−AF−2689−01 TCGA−CA−6715−01 TCGA−DY−A1DF−01 TCGA−CA−5254−01 TCGA−AZ−6607−01 TCGA−AA−3870−01 TCGA−AA−A02K−01 TCGA−D5−5537−01 TCGA−AA−3989−01 TCGA−AA−3502−01 TCGA−AA−3695−01 TCGA−AA−3688−01 TCGA−AG−3609−01 TCGA−AA−3526−01 TCGA−AA−A01Q−01 TCGA−CI−6621−01 TCGA−EI−6506−01 TCGA−AF−3400−01 TCGA−DM−A28F−01 TCGA−AF−5654−01 TCGA−CI−6620−01 TCGA−AA−3542−01 TCGA−AA−3518−01 TCGA−A6−6651−01 TCGA−DY−A1H8−01 TCGA−AA−3855−01 TCGA−A6−6138−01 TCGA−DM−A28K−01 TCGA−CM−6679−01 TCGA−AG−3575−01 TCGA−AA−A00E−01 TCGA−F4−6704−01 TCGA−AZ−6600−01 TCGA−AG−A00C−01 TCGA−AA−A01R−01 TCGA−AG−4001−01 TCGA−AG−3594−01 TCGA−AA−3556−01 TCGA−AA−3672−01 TCGA−F5−6702−01 TCGA−AG−A032−01 TCGA−AA−A00R−01 TCGA−AA−3514−01 TCGA−CK−5915−01 TCGA−CM−6677−01 TCGA−CM−5341−01 TCGA−AD−6901−01 TCGA−AA−3811−01 TCGA−AA−3534−01 TCGA−AA−3555−01 TCGA−F4−6703−01 TCGA−CK−6748−01 TCGA−AF−4110−01 TCGA−AD−6888−01 TCGA−AA−3554−01 TCGA−AA−3710−01 TCGA−D5−6533−01 TCGA−AZ−6605−01 TCGA−AG−4005−01 TCGA−AA−3975−01 TCGA−AA−3845−01 TCGA−AG−3581−01 TCGA−AA−A02J−01 TCGA−A6−6781−01 TCGA−AA−3984−01 TCGA−G4−6309−01 TCGA−CM−6167−01 TCGA−AH−6549−01 TCGA−AG−3726−01 TCGA−D5−6922−01 TCGA−AG−A025−01 TCGA−AA−3552−01 TCGA−D5−6932−01 TCGA−AG−3892−01 TCGA−AF−3913−01 TCGA−AF−2691−01 TCGA−AA−3976−01 TCGA−AA−3972−01 TCGA−AA−3666−01 TCGA−AA−3558−01 TCGA−AA−3549−01 TCGA−F5−6465−01 TCGA−DC−5337−01 TCGA−CA−5797−01 TCGA−AG−A01L−01 TCGA−AG−3894−01 TCGA−AA−A02F−01 TCGA−AA−A024−01 TCGA−AA−A00F−01 TCGA−AA−3973−01 TCGA−AA−3819−01 TCGA−A6−2678−01 TCGA−AG−A002−01 TCGA−AD−6889−01 TCGA−D5−6930−01 TCGA−AA−3516−01 TCGA−G4−6626−01 TCGA−EI−6508−01 TCGA−D5−6539−01 TCGA−AD−6895−01 TCGA−AA−A022−01 TCGA−A6−6653−01 TCGA−EI−6510−01 TCGA−DM−A1DA−01 TCGA−D5−6928−01 TCGA−D5−6535−01 TCGA−AA−A00J−01 TCGA−AA−3966−01 TCGA−AA−3949−01 TCGA−AA−3833−01 TCGA−AA−3821−01 TCGA−AA−3525−01 TCGA−DM−A1D4−01 TCGA−CM−6170−01 TCGA−CM−5348−01 TCGA−CM−4744−01 TCGA−CK−5913−01 TCGA−AG−3885−01 TCGA−AA−A01P−01 TCGA−AA−3664−01 TCGA−A6−2676−01 TCGA−A6−2672−01 TCGA−G4−6321−01 TCGA−DY−A1DD−01 TCGA−DM−A1D6−01 TCGA−DC−6681−01 TCGA−CM−6675−01 TCGA−CM−5868−01 TCGA−CA−5796−01 TCGA−AZ−6603−01 TCGA−AY−6196−01 TCGA−AG−3578−01 TCGA−AA−A01D−01 TCGA−AA−A00D−01 TCGA−AA−3684−01 TCGA−AA−3543−01 TCGA−A6−5664−01 TCGA−CA−6717−01 TCGA−AA−A010−01 TCGA−AZ−4315−01 TCGA−G4−6586−01 TCGA−CM−6674−01 TCGA−A6−5665−01 TCGA−AZ−6598−01 TCGA−A6−5661−01 TCGA−CM−6171−01 TCGA−CK−5916−01 TCGA−AA−A00N−01 TCGA−AA−3977−01 TCGA−AA−3663−01 TCGA−G4−6628−01 TCGA−D5−6540−01 TCGA−CA−6718−01 TCGA−AZ−6601−01 TCGA−AD−6964−01 TCGA−AA−3864−01 TCGA−AA−3492−01 TCGA−CM−6162−01 TCGA−CM−5861−01 TCGA−AA−3947−01 TCGA−AA−3877−01 TCGA−G4−6588−01 TCGA−G4−6315−01 TCGA−EI−6507−01 TCGA−DY−A0XA−01 TCGA−CM−6168−01 TCGA−AY−6197−01 TCGA−AA−3662−01 TCGA−AA−3510−01 TCGA−A6−6780−01 TCGA−A6−6141−01 TCGA−G4−6307−01 TCGA−F4−6856−01 TCGA−F4−6570−01 TCGA−D5−6931−01 TCGA−CM−5864−01 TCGA−CM−4746−01 TCGA−AZ−6599−01 TCGA−AZ−5407−01 TCGA−AD−5900−01 TCGA−AA−3715−01 TCGA−AA−3713−01 TCGA−AA−3660−01 TCGA−G4−6304−01 TCGA−G4−6303−01 TCGA−F5−6811−01 TCGA−F4−6460−01 TCGA−EF−5830−01 TCGA−DY−A1DG−01 TCGA−DM−A28H−01 TCGA−DM−A1D9−01 TCGA−DC−6158−01 TCGA−D5−6534−01 TCGA−D5−5538−01 TCGA−CM−6164−01 TCGA−CM−6161−01 TCGA−CM−4743−01 TCGA−CK−4952−01 TCGA−CK−4950−01 TCGA−AY−5543−01 TCGA−AU−6004−01 TCGA−AA−3950−01 TCGA−AA−3815−01 TCGA−AA−3697−01 TCGA−AA−3496−01 TCGA−G4−6299−01 TCGA−DM−A1D7−01 TCGA−DM−A0XF−01 TCGA−DM−A0XD−01 TCGA−DC−6682−01 TCGA−D5−6541−01 TCGA−D5−6536−01 TCGA−D5−6532−01 TCGA−D5−5540−01 TCGA−CM−6169−01 TCGA−CM−6166−01 TCGA−CM−5349−01 TCGA−CM−4752−01 TCGA−CK−6747−01 TCGA−CK−6746−01 TCGA−CK−5914−01 TCGA−CK−4947−01 TCGA−AZ−6608−01 TCGA−AG−A02N−01 TCGA−AF−6136−01 TCGA−AA−A01V−01 TCGA−AA−3712−01 TCGA−A6−5660−01 TCGA−G5−6235−01 TCGA−G4−6625−01 TCGA−G4−6323−01 TCGA−G4−6310−01 TCGA−G4−6293−01 TCGA−F5−6571−01 TCGA−F4−6855−01 TCGA−F4−6854−01 TCGA−F4−6809−01 TCGA−F4−6569−01 TCGA−F4−6459−01 TCGA−DT−5265−01 TCGA−DM−A28G−01 TCGA−DM−A28C−01 TCGA−DM−A285−01 TCGA−DM−A1DB−01 TCGA−DM−A0X9−01 TCGA−DC−6683−01 TCGA−DC−6160−01 TCGA−D5−7000−01 TCGA−D5−6929−01 TCGA−D5−6927−01 TCGA−D5−6920−01 TCGA−D5−6898−01 TCGA−D5−6538−01 TCGA−D5−6529−01 TCGA−D5−5541−01 TCGA−CM−6680−01 TCGA−CM−6678−01 TCGA−CM−5862−01 TCGA−CM−5860−01 TCGA−CM−5344−01 TCGA−CI−6622−01 TCGA−CI−6619−01 TCGA−AZ−6606−01 TCGA−AU−3779−01 TCGA−AH−6643−01 TCGA−AG−A020−01 TCGA−AG−3887−01 TCGA−AD−6963−01 TCGA−AA−3852−01 TCGA−AA−3850−01 TCGA−AA−3812−01 TCGA−AA−3673−01 TCGA−AA−3655−01 TCGA−AA−3511−01 TCGA−AA−3489−01 TCGA−A6−6652−01 TCGA−A6−6649−01 TCGA−A6−5666−01 TCGA−A6−5662−01 TCGA−A6−5657−01 TCGA−A6−5656−01 TCGA−A6−4105−01 TCGA−A6−3809−01 TCGA−G4−6317−01 TCGA−F5−6813−01 TCGA−F4−6808−01 TCGA−F4−6807−01 TCGA−F4−6805−01 TCGA−DY−A1DC−01 TCGA−DM−A1HA−01 TCGA−DM−A1D8−01 TCGA−DC−6157−01 TCGA−DC−5869−01 TCGA−D5−6926−01 TCGA−D5−6923−01 TCGA−D5−6537−01 TCGA−D5−5539−01 TCGA−CM−6676−01 TCGA−CM−6172−01 TCGA−CM−4747−01 TCGA−CL−5918−01 TCGA−CL−5917−01 TCGA−CK−5912−01 TCGA−CK−4948−01 TCGA−CI−6624−01 TCGA−CA−6719−01 TCGA−AZ−5403−01 TCGA−AZ−4682−01 TCGA−AZ−4616−01 TCGA−AY−6386−01 TCGA−AH−6644−01 TCGA−AH−6544−01 TCGA−AG−A00H−01 TCGA−AG−4015−01 TCGA−AG−3901−01 TCGA−AG−3878−01 TCGA−AG−3742−01 TCGA−AG−3731−01 TCGA−AF−6672−01 TCGA−AF−2693−01 TCGA−AF−2687−01 TCGA−AD−6965−01 TCGA−AD−6899−01 TCGA−AD−6890−01 TCGA−AD−6548−01 TCGA−AA−A03J−01 TCGA−AA−A03F−01 TCGA−AA−A02Y−01 TCGA−AA−A02O−01 TCGA−AA−A01K−01 TCGA−AA−A01I−01 TCGA−AA−3956−01 TCGA−AA−3939−01 TCGA−AA−3866−01 TCGA−AA−3848−01 TCGA−AA−3837−01 TCGA−AA−3818−01 TCGA−AA−3696−01 TCGA−A6−6782−01 TCGA−A6−6654−01 TCGA−A6−5659−01 TCGA−A6−3808−01

FAS Pathway And Stress Induction Of HSP Regulation FDR = 4e−06%, FDR nod = 5.5e−06% Apoptotic Cleavage Of Cell Adhesion Proteins FDR = 1.9e−12%, FDR nod = 2.3e−11%

TCGA−D5−6928−01 TCGA−CM−6172−01 TCGA−AA−A00A−01 TCGA−AA−3949−01 TCGA−AA−3679−01 TCGA−F4−6807−01 TCGA−AZ−6599−01 TCGA−AY−6386−01 TCGA−AA−3977−01 TCGA−AA−3710−01 TCGA−G4−6309−01 TCGA−F5−6702−01 TCGA−D5−6536−01 TCGA−CM−5868−01 TCGA−CM−5862−01 TCGA−CM−4743−01 TCGA−CL−5918−01 TCGA−CK−5916−01 TCGA−CI−6624−01 TCGA−AU−6004−01 TCGA−AG−A015−01 TCGA−AA−3712−01 TCGA−A6−5661−01 TCGA−G4−6586−01 TCGA−G4−6317−01 TCGA−CM−6166−01 TCGA−CK−5913−01 TCGA−CA−6717−01 TCGA−AZ−6608−01 TCGA−AZ−4315−01 TCGA−AG−A002−01 TCGA−A6−5665−01 TCGA−A6−5657−01 TCGA−G5−6235−01 TCGA−G4−6628−01 TCGA−G4−6625−01 TCGA−G4−6588−01 TCGA−G4−6315−01 TCGA−G4−6307−01 TCGA−G4−6306−01 TCGA−G4−6304−01 TCGA−G4−6303−01 TCGA−G4−6293−01 TCGA−F4−6856−01 TCGA−F4−6854−01 TCGA−F4−6703−01 TCGA−F4−6570−01 TCGA−DM−A28K−01 TCGA−DM−A28H−01 TCGA−D5−6927−01 TCGA−D5−6537−01 TCGA−D5−6535−01 TCGA−D5−6532−01 TCGA−D5−5540−01 TCGA−CM−6680−01 TCGA−CM−6676−01 TCGA−CM−6161−01 TCGA−CM−5860−01 TCGA−CM−5349−01 TCGA−CK−4952−01 TCGA−CK−4948−01 TCGA−CA−6718−01 TCGA−AZ−6607−01 TCGA−AZ−6601−01 TCGA−AY−6197−01 TCGA−AU−3779−01 TCGA−AG−A02N−01 TCGA−AG−A011−01 TCGA−AF−4110−01 TCGA−AD−6964−01 TCGA−AD−6895−01 TCGA−AD−6889−01 TCGA−AA−A01P−01 TCGA−AA−A010−01 TCGA−AA−A00N−01 TCGA−AA−3984−01 TCGA−AA−3930−01 TCGA−AA−3864−01 TCGA−AA−3815−01 TCGA−AA−3811−01 TCGA−AA−3715−01 TCGA−AA−3663−01 TCGA−AA−3655−01 TCGA−AA−3492−01 TCGA−A6−6781−01 TCGA−A6−6780−01 TCGA−A6−6653−01 TCGA−A6−6141−01 TCGA−A6−5666−01 TCGA−A6−5659−01 TCGA−A6−5656−01 TCGA−A6−3809−01

TCGA−F4−6805−01 TCGA−A6−3808−01 TCGA−F5−6464−01 TCGA−CM−6166−01 TCGA−CM−6162−01 TCGA−G4−6299−01 TCGA−AA−3984−01 TCGA−AA−3877−01 TCGA−CM−5861−01 TCGA−AA−A022−01 TCGA−AA−A00E−01 TCGA−AA−3525−01 TCGA−A6−6653−01 TCGA−AA−3864−01 TCGA−AA−3492−01 TCGA−EI−6506−01 TCGA−D5−5539−01 TCGA−AZ−5403−01 TCGA−A6−5666−01 TCGA−AA−A010−01 TCGA−G4−6307−01 TCGA−DY−A1H8−01 TCGA−DC−6158−01 TCGA−D5−6931−01 TCGA−CM−6169−01 TCGA−AA−A01F−01 TCGA−AA−3966−01 TCGA−AA−3950−01 TCGA−AA−3949−01 TCGA−AG−A002−01 TCGA−AA−3977−01 TCGA−AA−3715−01 TCGA−A6−6781−01 TCGA−AY−6196−01 TCGA−AD−6895−01 TCGA−AA−3516−01 TCGA−F4−6704−01 TCGA−DM−A0X9−01 TCGA−CK−5913−01 TCGA−CA−5796−01 TCGA−AA−3855−01 TCGA−AA−3833−01 TCGA−AA−3819−01 TCGA−AA−3815−01 TCGA−AA−3811−01 TCGA−AA−3672−01 TCGA−A6−2672−01 TCGA−G4−6304−01 TCGA−D5−6928−01 TCGA−AA−A01R−01 TCGA−AA−3713−01 TCGA−DM−A1HA−01 TCGA−D5−6539−01 TCGA−AU−6004−01 TCGA−AD−5900−01 TCGA−A6−6141−01 TCGA−G5−6235−01 TCGA−G4−6321−01 TCGA−G4−6317−01 TCGA−G4−6310−01 TCGA−G4−6306−01 TCGA−F4−6570−01 TCGA−F4−6460−01 TCGA−EF−5830−01 TCGA−DM−A28F−01 TCGA−DM−A28E−01 TCGA−DM−A282−01 TCGA−D5−6932−01 TCGA−D5−6930−01 TCGA−D5−6529−01 TCGA−CM−6679−01 TCGA−CM−6678−01 TCGA−CM−6172−01 TCGA−CM−6170−01 TCGA−CM−6161−01 TCGA−CM−5868−01 TCGA−CM−5348−01 TCGA−CK−6747−01 TCGA−CK−5914−01 TCGA−CK−5912−01 TCGA−CK−4950−01 TCGA−CA−6715−01 TCGA−CA−5797−01 TCGA−AZ−6600−01 TCGA−AZ−4616−01 TCGA−AY−6386−01 TCGA−AY−6197−01 TCGA−AH−6643−01 TCGA−AH−6544−01 TCGA−AG−3731−01 TCGA−AF−6136−01 TCGA−AF−2687−01 TCGA−AD−6889−01 TCGA−AA−A02K−01 TCGA−AA−3821−01 TCGA−AA−3502−01 TCGA−A6−6648−01 TCGA−A6−5662−01 TCGA−A6−5659−01 TCGA−A6−5657−01 TCGA−A6−3809−01 TCGA−CA−6717−01 TCGA−AA−A00N−01 TCGA−CA−6718−01 TCGA−G4−6586−01 TCGA−AA−3663−01 TCGA−AA−3510−01 TCGA−A6−6780−01 TCGA−D5−6541−01 TCGA−D5−6540−01 TCGA−CM−4743−01 TCGA−CK−5916−01 TCGA−AZ−4315−01 TCGA−AU−3779−01 TCGA−AG−3892−01 TCGA−G4−6628−01 TCGA−G4−6588−01 TCGA−G4−6323−01 TCGA−F5−6813−01 TCGA−F5−6465−01 TCGA−F4−6856−01 TCGA−DY−A1DG−01 TCGA−DY−A0XA−01 TCGA−DM−A1D6−01 TCGA−DM−A1D4−01 TCGA−DC−5337−01 TCGA−D5−6538−01 TCGA−D5−6537−01 TCGA−D5−6536−01 TCGA−D5−6535−01 TCGA−D5−6533−01 TCGA−D5−5540−01 TCGA−CM−6171−01 TCGA−CM−6168−01 TCGA−CM−5860−01 TCGA−CM−5349−01 TCGA−CM−5344−01 TCGA−CM−4752−01 TCGA−CM−4744−01 TCGA−CK−5915−01 TCGA−CK−4952−01 TCGA−AZ−6601−01 TCGA−AZ−6599−01 TCGA−AZ−6598−01 TCGA−AG−3732−01 TCGA−AF−2693−01 TCGA−AD−6964−01 TCGA−AA−A00U−01 TCGA−AA−3697−01 TCGA−AA−3662−01 TCGA−AA−3660−01 TCGA−A6−5661−01 TCGA−G4−6626−01 TCGA−G4−6625−01 TCGA−G4−6315−01 TCGA−G4−6303−01 TCGA−F5−6811−01 TCGA−F5−6571−01 TCGA−F4−6855−01 TCGA−F4−6854−01 TCGA−F4−6703−01 TCGA−F4−6569−01 TCGA−EI−6510−01 TCGA−DY−A1DF−01 TCGA−DM−A1DB−01 TCGA−DM−A1D7−01 TCGA−DM−A0XF−01 TCGA−DC−6682−01 TCGA−CM−6675−01 TCGA−CM−6164−01 TCGA−CM−6163−01 TCGA−CM−4747−01 TCGA−CL−5917−01 TCGA−CK−6746−01 TCGA−AZ−6608−01 TCGA−AZ−6605−01 TCGA−AZ−5407−01 TCGA−AH−6547−01 TCGA−AG−A020−01 TCGA−AG−3881−01 TCGA−AG−3575−01 TCGA−AF−6655−01 TCGA−AD−6901−01 TCGA−AA−A01K−01 TCGA−AA−3831−01 TCGA−AA−3712−01 TCGA−AA−3696−01 TCGA−AA−3655−01 TCGA−AA−3534−01 TCGA−AA−3496−01 TCGA−A6−5665−01 TCGA−A6−5660−01 TCGA−A6−2678−01


TCGA−AZ−4323−01 TCGA−A6−6653−01 TCGA−G5−6235−01 TCGA−AG−3731−01 TCGA−AA−3554−01 TCGA−AA−A02W−01 TCGA−AA−A01Z−01 TCGA−AA−3517−01 TCGA−AG−3587−01 TCGA−CA−6715−01 TCGA−AY−4070−01 TCGA−G4−6626−01 TCGA−AA−3980−01 TCGA−A6−6648−01 TCGA−AA−3561−01 TCGA−AG−3598−01 TCGA−A6−6780−01 TCGA−AA−3710−01 TCGA−AA−3543−01 TCGA−D5−6929−01 TCGA−AY−6386−01 TCGA−AA−A02F−01 TCGA−A6−6782−01 TCGA−D5−6930−01 TCGA−AA−3544−01 TCGA−A6−2676−01 TCGA−AA−A03F−01 TCGA−F4−6704−01 TCGA−AA−3949−01 TCGA−A6−5662−01 TCGA−G4−6293−01 TCGA−CM−6161−01 TCGA−AG−A011−01 TCGA−AA−3555−01 TCGA−AA−3877−01 TCGA−CI−6620−01 TCGA−AA−3496−01 TCGA−A6−6781−01 TCGA−F4−6805−01 TCGA−AG−4005−01 TCGA−AG−3584−01 TCGA−AA−A00D−01 TCGA−A6−2683−01 TCGA−G4−6309−01 TCGA−CL−5918−01 TCGA−F5−6702−01 TCGA−CM−5868−01 TCGA−CI−6624−01 TCGA−AG−A015−01 TCGA−EI−6507−01 TCGA−CM−6674−01 TCGA−CM−5341−01 TCGA−DC−6155−01 TCGA−D5−6540−01 TCGA−AA−3833−01 TCGA−AA−3516−01 TCGA−G4−6628−01 TCGA−DC−5337−01 TCGA−AA−3492−01 TCGA−D5−6535−01 TCGA−CK−4952−01 TCGA−AA−3845−01 TCGA−A6−6141−01 TCGA−A6−5666−01 TCGA−F5−6812−01 TCGA−AG−A00Y−01 TCGA−AG−3727−01 TCGA−AD−6548−01 TCGA−AA−3986−01 TCGA−AA−3952−01 TCGA−F4−6856−01 TCGA−AY−6197−01 TCGA−AA−3950−01 TCGA−A6−5657−01 TCGA−G4−6304−01 TCGA−CM−4746−01 TCGA−AA−A00A−01 TCGA−D5−6931−01 TCGA−CM−5348−01 TCGA−AG−3726−01 TCGA−AG−3600−01 TCGA−AD−6890−01 TCGA−AA−3976−01 TCGA−AA−3819−01 TCGA−AA−3695−01 TCGA−AA−3519−01 TCGA−CK−4947−01 TCGA−D5−6927−01 TCGA−CM−6171−01 TCGA−CM−5349−01 TCGA−F5−6464−01 TCGA−AD−6888−01 TCGA−A6−6138−01 TCGA−F4−6855−01 TCGA−DM−A0XF−01 TCGA−D5−6532−01 TCGA−CM−6675−01 TCGA−AH−6644−01 TCGA−AG−3902−01 TCGA−AG−3898−01 TCGA−AG−3732−01 TCGA−AA−3994−01 TCGA−AA−3869−01 TCGA−AA−3660−01 TCGA−A6−4105−01 TCGA−AZ−4315−01 TCGA−AG−3892−01 TCGA−AA−3977−01 TCGA−CA−6718−01 TCGA−AD−6889−01 TCGA−AA−3715−01 TCGA−G4−6586−01 TCGA−CK−5916−01 TCGA−AA−A00J−01 TCGA−AA−3672−01 TCGA−A6−5661−01 TCGA−F4−6570−01 TCGA−AA−A022−01 TCGA−D5−6926−01 TCGA−CA−6716−01 TCGA−AF−2693−01 TCGA−AA−3489−01 TCGA−F4−6807−01 TCGA−DM−A0XD−01 TCGA−CM−4752−01 TCGA−AG−A036−01 TCGA−AD−6963−01 TCGA−AA−3972−01 TCGA−AA−3866−01 TCGA−AA−A010−01 TCGA−AA−3713−01 TCGA−AA−A01Q−01 TCGA−AA−3984−01 TCGA−AA−3864−01 TCGA−A6−5665−01 TCGA−CM−5861−01 TCGA−AG−A02N−01 TCGA−CM−6172−01 TCGA−CM−4743−01 TCGA−CK−4948−01 TCGA−AH−6544−01 TCGA−AA−3947−01 TCGA−AA−3861−01 TCGA−AA−3815−01 TCGA−F4−6703−01 TCGA−DM−A1DA−01 TCGA−D5−5538−01 TCGA−CK−6746−01 TCGA−CK−5913−01 TCGA−AG−3599−01 TCGA−AD−6899−01 TCGA−AD−6895−01 TCGA−AA−3814−01 TCGA−AA−3510−01 TCGA−A6−2672−01 TCGA−F4−6459−01 TCGA−EI−6510−01 TCGA−D5−6932−01 TCGA−D5−6541−01 TCGA−CM−6167−01 TCGA−CM−6163−01 TCGA−AZ−6608−01 TCGA−AZ−4616−01 TCGA−AY−4071−01 TCGA−AG−3581−01 TCGA−AF−4110−01 TCGA−AA−3875−01 TCGA−AA−3850−01 TCGA−AA−3818−01 TCGA−A6−6649−01 TCGA−A6−6137−01 TCGA−AG−A002−01 TCGA−CA−6717−01 TCGA−D5−6928−01 TCGA−AA−A00N−01 TCGA−CM−6170−01 TCGA−AZ−6601−01 TCGA−AU−6004−01 TCGA−AZ−6600−01 TCGA−AZ−6598−01 TCGA−AY−6196−01 TCGA−AA−A00E−01 TCGA−AA−3712−01 TCGA−G4−6588−01 TCGA−G4−6306−01 TCGA−G4−6299−01 TCGA−D5−6539−01 TCGA−D5−5540−01 TCGA−CM−6162−01 TCGA−CM−5862−01 TCGA−CM−5860−01 TCGA−AZ−5407−01 TCGA−AD−6964−01 TCGA−AD−5900−01 TCGA−AA−A00R−01 TCGA−AA−3966−01 TCGA−AA−3663−01 TCGA−AA−3502−01 TCGA−G4−6317−01 TCGA−G4−6307−01 TCGA−G4−6303−01 TCGA−F5−6465−01 TCGA−DY−A1DG−01 TCGA−DY−A0XA−01 TCGA−DM−A28F−01 TCGA−DM−A285−01 TCGA−DM−A1DB−01 TCGA−D5−6898−01 TCGA−D5−6536−01 TCGA−D5−6534−01 TCGA−CM−6676−01 TCGA−CM−6168−01 TCGA−CM−6166−01 TCGA−AZ−6599−01 TCGA−AZ−5403−01 TCGA−AY−5543−01 TCGA−AU−3779−01 TCGA−AD−6901−01 TCGA−AA−A01R−01 TCGA−AA−3982−01 TCGA−AA−3697−01 TCGA−AA−3542−01 TCGA−AA−3518−01 TCGA−G4−6315−01 TCGA−F4−6809−01 TCGA−F4−6808−01 TCGA−F4−6460−01 TCGA−EF−5830−01 TCGA−DY−A1DF−01 TCGA−DY−A1DD−01 TCGA−DM−A1D8−01 TCGA−D5−6920−01 TCGA−D5−6538−01 TCGA−D5−6537−01 TCGA−D5−6533−01 TCGA−D5−5539−01 TCGA−CM−6680−01 TCGA−CM−6677−01 TCGA−CM−6169−01 TCGA−CM−5344−01 TCGA−CK−6751−01 TCGA−CK−6748−01 TCGA−CK−5915−01 TCGA−CK−5914−01 TCGA−AZ−6603−01 TCGA−AG−3742−01 TCGA−AF−2687−01 TCGA−AA−A02K−01 TCGA−AA−3968−01 TCGA−AA−3811−01 TCGA−A6−5660−01 TCGA−A6−3809−01

RPA2

RMI2

RMI1

RMI2

RMI1

RAD9A

RAD9B

RAD51AP1

RAD51C

MRE11A

RBBP8

RAD1

RAD51D

NBN

RAD17

KAT5

XRCC2

CHEK1

XRCC2

ATRIP TOP3A

KAT5

RFC5

BRIP1

MAP3K7 TJP2

known HCG mut

wt

BLM

BRIP1

DNA2

RPA1

RTEL1

XRCC3

RPA3

EXO1

EXO1

MRE11A

NBN

RAD51B

RAD51B

RAD51D

RAD51C

RFC2

RBBP8

RFC4

unknown CG mut ATM

wt TOPBP1 RAD50

WRN

HUS1 BLM

wt wt

known HCG mut RAD50 BRCA1

DNA2

BARD1

BRCA1

BRCA2

BRCA2

unknown CG mut

ATR ATM

BARD1

wt

WRN

Presynaptic Phase Of Homologous DNA Pairing And Strand Exchange FDR = 2e−12%, FDR nod = 0.0018% Homologous DNA Pairing And Strand Exchange Resolution Of D Loop Structures Through Synthesis Dependent Strand Annealing (SDSA) FDR = 1.9e−12%, FDR nod = 0.014%

TOP3A

known HCG mut PALB2

DAXX DSG1

unknown CG mut

known HCG mut

wt


EGFR ERBB4 GLI3 ERBB2 ERBB3 MAP2K4 APAF1 DAXX MAPK10 CASP9 GLI1 PARP1 PARP4 MAPK9 CASP8 FAS LMNB1 PARP3 SCIN CAPG CASP10 CFLAR CYC1 FAF1 LMNA LMNB2 MAP3K5 CASP3 CASP6 CASP7 DFFB FADD FASLG GSN JUN MAPK8 PARP2

unknown CG mut


FAS Signaling Pathway FDR = 2.4e−12%, FDR nod = 3.7e−06%

known HCG mut known HCG mut CDH1

unknown CG mut unknown CG mut CTNNB1

PRKDC

DSP

TJP1

DSG3

PKP1

DSG2

ARHGDIB

CASP3

OCLN

JUN

TCGA−A6−6651−01 TCGA−DY−A0XA−01 TCGA−A6−5659−01 TCGA−AA−A02J−01 TCGA−AG−3896−01 TCGA−AA−3949−01 TCGA−CM−6161−01 TCGA−CM−5344−01 TCGA−EI−6510−01 TCGA−AA−3525−01 TCGA−AA−3521−01 TCGA−AA−3511−01 TCGA−CM−6676−01 TCGA−AA−A004−01 TCGA−AA−3877−01 TCGA−CI−6621−01 TCGA−CA−6716−01 TCGA−AA−3947−01 TCGA−AA−3667−01 TCGA−AZ−6600−01 TCGA−AA−3845−01 TCGA−DT−5265−01 TCGA−D5−6922−01 TCGA−AA−3672−01 TCGA−AA−3812−01 TCGA−D5−6927−01 TCGA−A6−2678−01 TCGA−CK−4950−01 TCGA−AF−6672−01 TCGA−A6−2671−01 TCGA−DY−A1DD−01 TCGA−DM−A1HA−01 TCGA−A6−5657−01 TCGA−AA−A01Q−01 TCGA−CM−6163−01 TCGA−AY−4071−01 TCGA−AA−3696−01 TCGA−AA−3815−01 TCGA−AF−2687−01 TCGA−AA−A01P−01 TCGA−AA−3980−01 TCGA−CM−6674−01 TCGA−CK−5915−01 TCGA−AD−5900−01 TCGA−A6−3807−01 TCGA−AG−3732−01 TCGA−AA−3554−01 TCGA−AD−6895−01 TCGA−D5−6534−01 TCGA−AA−A00J−01 TCGA−CM−4744−01 TCGA−AY−5543−01 TCGA−A6−2672−01 TCGA−CK−5916−01 TCGA−A6−3809−01 TCGA−DM−A1D6−01 TCGA−D5−5537−01 TCGA−CK−4948−01 TCGA−CI−6619−01 TCGA−CA−5797−01 TCGA−AA−A00E−01 TCGA−A6−6782−01 TCGA−AA−3864−01 TCGA−G4−6299−01 TCGA−A6−2676−01 TCGA−F4−6806−01 TCGA−DM−A285−01 TCGA−DC−6160−01 TCGA−D5−6931−01 TCGA−CM−6675−01 TCGA−CM−6165−01 TCGA−CA−5255−01 TCGA−AY−4070−01 TCGA−AH−6549−01 TCGA−AA−3543−01 TCGA−A6−6648−01 TCGA−CM−6162−01 TCGA−AA−3715−01 TCGA−AD−6964−01 TCGA−DM−A0XD−01 TCGA−D5−6930−01 TCGA−CM−6678−01 TCGA−CM−6172−01 TCGA−CM−5863−01 TCGA−AG−3601−01 TCGA−AA−3712−01 TCGA−A6−6654−01 TCGA−F4−6703−01 TCGA−F4−6460−01 TCGA−DY−A1DG−01 TCGA−DM−A1D9−01 TCGA−D5−6926−01 TCGA−CI−6624−01 TCGA−CI−6622−01 TCGA−AG−A00C−01 TCGA−AF−5654−01 TCGA−AA−3562−01 TCGA−A6−5656−01 TCGA−AG−A002−01 TCGA−CA−6717−01 TCGA−AA−A010−01 TCGA−AA−A00N−01 TCGA−AA−3984−01 TCGA−AA−3510−01 TCGA−CK−6746−01 TCGA−AZ−6598−01 TCGA−A6−5665−01 TCGA−CA−6718−01 TCGA−AZ−4315−01 TCGA−AA−3977−01 TCGA−AA−3713−01 TCGA−AA−3496−01 TCGA−CM−5861−01 TCGA−AG−3892−01 TCGA−AA−3663−01 TCGA−G4−6628−01 TCGA−F4−6570−01 TCGA−CM−4743−01 TCGA−A6−6781−01 TCGA−G4−6309−01 TCGA−AY−6197−01 TCGA−AD−6889−01 TCGA−A6−6780−01 TCGA−G4−6588−01 TCGA−G4−6317−01 TCGA−G4−6307−01 TCGA−F4−6856−01 TCGA−D5−6540−01 TCGA−D5−6536−01 TCGA−CM−6171−01 TCGA−AZ−6601−01 TCGA−AU−6004−01 TCGA−AA−3950−01 TCGA−AA−3518−01 TCGA−AA−3492−01 TCGA−A6−6653−01 TCGA−EI−6507−01 TCGA−EF−5830−01 TCGA−DM−A0XF−01 TCGA−D5−6928−01 TCGA−CM−6677−01 TCGA−CM−5862−01 TCGA−CM−5348−01 TCGA−CK−6751−01 TCGA−CK−5913−01 TCGA−CK−4952−01 TCGA−AZ−6599−01 TCGA−AA−A022−01 TCGA−AA−3966−01 TCGA−AA−3710−01 TCGA−AA−3664−01 TCGA−A6−6141−01 TCGA−A6−5661−01 TCGA−G4−6586−01 TCGA−G4−6315−01 TCGA−G4−6293−01 TCGA−F5−6813−01 TCGA−F4−6808−01 TCGA−EI−6508−01 TCGA−EI−6506−01 TCGA−DY−A1H8−01 TCGA−DY−A1DF−01 TCGA−DC−6155−01 TCGA−DC−5337−01 TCGA−D5−6929−01 TCGA−D5−6923−01 TCGA−D5−6920−01 TCGA−D5−6535−01 TCGA−D5−6533−01 TCGA−D5−5538−01 TCGA−CM−6679−01 TCGA−CM−6170−01 TCGA−CM−5868−01 TCGA−CM−5864−01 TCGA−CM−4752−01 TCGA−CL−5917−01 TCGA−CK−5912−01 TCGA−CK−4947−01 TCGA−CA−6715−01 TCGA−AZ−6608−01 TCGA−AZ−6603−01 TCGA−AH−6643−01 TCGA−AH−6544−01 TCGA−AG−3885−01 TCGA−AD−6901−01 TCGA−AA−A01R−01 TCGA−AA−3811−01 TCGA−AA−3697−01 TCGA−AA−3662−01 TCGA−AA−3527−01 TCGA−AA−3502−01 TCGA−G5−6641−01 TCGA−G5−6235−01 TCGA−G4−6321−01 TCGA−G4−6306−01 TCGA−G4−6304−01 TCGA−F5−6702−01 TCGA−F4−6854−01 TCGA−F4−6809−01 TCGA−F4−6807−01 TCGA−DY−A1DC−01 TCGA−DM−A28K−01 TCGA−DM−A28H−01 TCGA−DM−A28G−01 TCGA−DM−A28F−01 TCGA−DM−A28E−01 TCGA−DM−A28C−01 TCGA−DM−A1DB−01 TCGA−DM−A1D4−01 TCGA−DC−6683−01 TCGA−D5−7000−01 TCGA−D5−6924−01 TCGA−D5−6898−01 TCGA−D5−6541−01 TCGA−D5−6539−01 TCGA−D5−6538−01 TCGA−D5−6537−01 TCGA−D5−6532−01 TCGA−D5−6529−01 TCGA−D5−5539−01 TCGA−CM−6680−01 TCGA−CM−6164−01 TCGA−CM−5860−01 TCGA−CM−5349−01 TCGA−CK−6748−01 TCGA−CK−5914−01 TCGA−CA−6719−01 TCGA−AZ−5407−01 TCGA−AZ−5403−01 TCGA−AZ−4682−01 TCGA−AY−6196−01 TCGA−AU−3779−01 TCGA−AG−3742−01 TCGA−AG−3731−01 TCGA−AG−3727−01 TCGA−AG−3600−01 TCGA−AF−6655−01 TCGA−AF−2693−01 TCGA−AD−6963−01 TCGA−AD−6899−01 TCGA−AD−6890−01 TCGA−AD−6548−01 TCGA−AA−A02Y−01 TCGA−AA−3861−01 TCGA−AA−3860−01 TCGA−AA−3819−01 TCGA−AA−3679−01 TCGA−AA−3678−01 TCGA−AA−3660−01 TCGA−AA−3655−01 TCGA−AA−3555−01 TCGA−AA−3530−01 TCGA−AA−3522−01 TCGA−AA−3516−01 TCGA−A6−5664−01 TCGA−A6−5660−01 TCGA−A6−4105−01

TCGA−DY−A0XA−01 TCGA−A6−5659−01 TCGA−AA−A02J−01 TCGA−AA−3949−01 TCGA−AA−3667−01 TCGA−CM−5344−01 TCGA−D5−6927−01 TCGA−AG−3882−01 TCGA−AA−3525−01 TCGA−AA−3521−01 TCGA−DC−5869−01 TCGA−CK−6747−01 TCGA−AZ−6600−01 TCGA−AA−3845−01 TCGA−DT−5265−01 TCGA−D5−6922−01 TCGA−AA−3672−01 TCGA−AA−3812−01 TCGA−A6−2676−01 TCGA−AA−A01Q−01 TCGA−CM−6163−01 TCGA−AY−4071−01 TCGA−AA−3696−01 TCGA−AA−3815−01 TCGA−G4−6299−01 TCGA−AF−2687−01 TCGA−AA−A01P−01 TCGA−AA−3980−01 TCGA−CM−6674−01 TCGA−CK−5915−01 TCGA−AD−5900−01 TCGA−A6−3807−01 TCGA−AG−3732−01 TCGA−AA−3554−01 TCGA−AD−6895−01 TCGA−D5−6534−01 TCGA−AA−A00J−01 TCGA−CM−4744−01 TCGA−AY−5543−01 TCGA−A6−2672−01 TCGA−AA−3864−01 TCGA−CM−6161−01 TCGA−AA−3947−01 TCGA−CM−6166−01 TCGA−CA−6716−01 TCGA−AA−3854−01 TCGA−AA−3543−01 TCGA−CK−5916−01 TCGA−A6−3809−01 TCGA−DM−A1D6−01 TCGA−D5−5537−01 TCGA−CK−4948−01 TCGA−CI−6619−01 TCGA−CA−5797−01 TCGA−AA−A00E−01 TCGA−A6−6782−01 TCGA−CM−6162−01 TCGA−AA−3715−01 TCGA−DM−A0XD−01 TCGA−D5−6930−01 TCGA−CM−6678−01 TCGA−CM−5863−01 TCGA−AG−3601−01 TCGA−AD−6964−01 TCGA−AA−3712−01 TCGA−F4−6703−01 TCGA−F4−6460−01 TCGA−DY−A1DG−01 TCGA−DM−A1D9−01 TCGA−D5−6926−01 TCGA−CM−6172−01 TCGA−CI−6624−01 TCGA−CI−6622−01 TCGA−AG−A00C−01 TCGA−AF−5654−01 TCGA−AA−3562−01 TCGA−A6−6654−01 TCGA−A6−5656−01 TCGA−AG−A002−01 TCGA−CA−6717−01 TCGA−AA−A010−01 TCGA−AA−A00N−01 TCGA−CM−5861−01 TCGA−AZ−4315−01 TCGA−AA−3984−01 TCGA−AA−3977−01 TCGA−AA−3510−01 TCGA−G4−6628−01 TCGA−F4−6570−01 TCGA−CM−4743−01 TCGA−CK−6746−01 TCGA−AG−3892−01 TCGA−AA−3663−01 TCGA−AA−3496−01 TCGA−A6−6780−01 TCGA−A6−5665−01 TCGA−G4−6588−01 TCGA−CM−6171−01 TCGA−CA−6718−01 TCGA−AZ−6598−01 TCGA−AA−3713−01 TCGA−G4−6307−01 TCGA−D5−6540−01 TCGA−CM−6677−01 TCGA−AZ−6601−01 TCGA−AZ−6599−01 TCGA−AD−6889−01 TCGA−AA−3518−01 TCGA−A6−6781−01 TCGA−A6−5661−01 TCGA−G4−6309−01 TCGA−F4−6856−01 TCGA−EI−6507−01 TCGA−CM−5862−01 TCGA−CM−4752−01 TCGA−AY−6197−01 TCGA−AA−A022−01 TCGA−AA−3966−01 TCGA−AA−3710−01 TCGA−AA−3492−01 TCGA−A6−6653−01 TCGA−G4−6586−01 TCGA−G4−6317−01 TCGA−F5−6813−01 TCGA−EI−6508−01 TCGA−EI−6506−01 TCGA−EF−5830−01 TCGA−DY−A1H8−01 TCGA−DY−A1DF−01 TCGA−DY−A1DC−01 TCGA−DM−A28F−01 TCGA−DM−A0XF−01 TCGA−DC−6155−01 TCGA−D5−6929−01 TCGA−D5−6928−01 TCGA−D5−6923−01 TCGA−D5−6536−01 TCGA−D5−6533−01 TCGA−CM−6679−01 TCGA−CM−5868−01 TCGA−CM−5864−01 TCGA−CK−6751−01 TCGA−CK−5913−01 TCGA−CK−4952−01 TCGA−CK−4947−01 TCGA−CA−6715−01 TCGA−AU−6004−01 TCGA−AH−6643−01 TCGA−AH−6544−01 TCGA−AG−3885−01 TCGA−AA−A01R−01 TCGA−AA−3950−01 TCGA−AA−3819−01 TCGA−AA−3697−01 TCGA−AA−3664−01 TCGA−AA−3662−01 TCGA−AA−3660−01 TCGA−AA−3527−01 TCGA−A6−6141−01 TCGA−A6−4105−01 TCGA−G5−6641−01 TCGA−G5−6235−01 TCGA−G4−6321−01 TCGA−G4−6315−01 TCGA−G4−6306−01 TCGA−G4−6304−01 TCGA−G4−6293−01 TCGA−F5−6702−01 TCGA−F4−6854−01 TCGA−F4−6809−01 TCGA−F4−6808−01 TCGA−F4−6807−01 TCGA−DM−A28K−01 TCGA−DM−A28H−01 TCGA−DM−A28G−01 TCGA−DM−A28E−01 TCGA−DM−A28C−01 TCGA−DM−A1DB−01 TCGA−DM−A1D4−01 TCGA−DC−6683−01 TCGA−DC−5337−01 TCGA−D5−7000−01 TCGA−D5−6924−01 TCGA−D5−6920−01 TCGA−D5−6898−01 TCGA−D5−6541−01 TCGA−D5−6539−01 TCGA−D5−6538−01 TCGA−D5−6537−01 TCGA−D5−6535−01 TCGA−D5−6532−01 TCGA−D5−6529−01 TCGA−D5−5539−01 TCGA−D5−5538−01 TCGA−CM−6680−01 TCGA−CM−6170−01 TCGA−CM−6164−01 TCGA−CM−5860−01 TCGA−CM−5349−01 TCGA−CM−5348−01 TCGA−CL−5917−01 TCGA−CK−6748−01 TCGA−CK−5914−01 TCGA−CK−5912−01 TCGA−CA−6719−01 TCGA−AZ−6608−01 TCGA−AZ−6603−01 TCGA−AZ−5407−01 TCGA−AZ−5403−01 TCGA−AZ−4682−01 TCGA−AY−6196−01 TCGA−AU−3779−01 TCGA−AG−3742−01 TCGA−AG−3731−01 TCGA−AG−3727−01 TCGA−AG−3600−01 TCGA−AF−6655−01 TCGA−AF−2693−01 TCGA−AD−6963−01 TCGA−AD−6901−01 TCGA−AD−6899−01 TCGA−AD−6890−01 TCGA−AD−6548−01 TCGA−AA−A02Y−01 TCGA−AA−3861−01 TCGA−AA−3860−01 TCGA−AA−3811−01 TCGA−AA−3679−01 TCGA−AA−3678−01 TCGA−AA−3655−01 TCGA−AA−3555−01 TCGA−AA−3530−01 TCGA−AA−3522−01 TCGA−AA−3516−01 TCGA−AA−3502−01 TCGA−A6−5664−01 TCGA−A6−5660−01

TRIF Mediated Programmed Cell Death FDR = 0.052%, FDR nod = 3.8% TP53 Regulates Transcription Of Death Receptors And Ligands FDR = 1.9e−12%, FDR nod = 3.6%

CASP8 TP53

TCGA−AA−3930−01 TCGA−D5−6928−01 TCGA−CM−5341−01 TCGA−AA−3680−01 TCGA−A6−6653−01 TCGA−D5−6539−01 TCGA−D5−5538−01 TCGA−AD−6888−01 TCGA−AA−A01P−01 TCGA−AA−A00N−01 TCGA−G4−6626−01 TCGA−DY−A1H8−01 TCGA−AA−3980−01 TCGA−AA−3833−01 TCGA−AA−3542−01 TCGA−G4−6628−01 TCGA−CA−6718−01 TCGA−D5−6898−01 TCGA−CM−5861−01 TCGA−CM−5349−01 TCGA−AA−A010−01 TCGA−AA−3984−01 TCGA−AA−3525−01 TCGA−AA−3510−01 TCGA−G4−6586−01 TCGA−F4−6856−01 TCGA−CM−6674−01 TCGA−CM−6162−01 TCGA−CM−5860−01 TCGA−AZ−6601−01 TCGA−AZ−6598−01 TCGA−AG−3909−01 TCGA−AD−6964−01 TCGA−AA−3860−01 TCGA−A6−6141−01 TCGA−A6−5665−01 TCGA−AZ−4315−01 TCGA−CK−5916−01 TCGA−AG−A002−01 TCGA−AA−3811−01 TCGA−F5−6702−01 TCGA−F4−6807−01 TCGA−CM−5344−01 TCGA−CK−6746−01 TCGA−AD−5900−01 TCGA−AA−3977−01 TCGA−AA−3971−01 TCGA−AA−3663−01 TCGA−AA−3529−01 TCGA−CA−6717−01 TCGA−EI−6507−01 TCGA−DM−A28F−01 TCGA−CM−4746−01 TCGA−AY−6197−01 TCGA−AD−6895−01 TCGA−AA−A022−01 TCGA−AA−A00R−01 TCGA−AA−A00J−01 TCGA−AA−A00A−01 TCGA−AA−3947−01 TCGA−AA−3864−01 TCGA−AA−3715−01 TCGA−AA−3710−01 TCGA−AA−3543−01 TCGA−AA−3518−01 TCGA−AA−3492−01 TCGA−AA−3489−01

TCGA−AA−3950−01 TCGA−G4−6588−01 TCGA−A6−6653−01 TCGA−AA−3947−01 TCGA−AA−3870−01 TCGA−AD−6895−01 TCGA−AA−3872−01 TCGA−AA−3855−01 TCGA−AG−3892−01 TCGA−AD−6889−01 TCGA−A6−6780−01 TCGA−CM−6674−01 TCGA−F5−6811−01 TCGA−AA−3994−01 TCGA−AA−3984−01 TCGA−A6−6141−01 TCGA−AD−6964−01 TCGA−D5−6928−01 TCGA−AA−3973−01 TCGA−AA−3877−01 TCGA−AA−3864−01 TCGA−AZ−4315−01 TCGA−CM−6678−01 TCGA−CM−5861−01 TCGA−AG−3574−01 TCGA−AA−3966−01 TCGA−A6−2677−01 TCGA−AG−A002−01 TCGA−CM−5344−01 TCGA−AA−A01R−01 TCGA−AA−A00O−01 TCGA−AA−3710−01 TCGA−AA−3696−01 TCGA−AA−3672−01 TCGA−AA−3516−01 TCGA−AA−3510−01 TCGA−AA−A010−01 TCGA−G4−6628−01 TCGA−D5−6927−01 TCGA−CM−6162−01 TCGA−CM−4743−01 TCGA−CK−5916−01 TCGA−AZ−6601−01 TCGA−AG−3598−01 TCGA−AA−3949−01 TCGA−G4−6315−01 TCGA−G4−6304−01 TCGA−G4−6293−01 TCGA−F5−6464−01 TCGA−F4−6856−01 TCGA−DY−A0XA−01 TCGA−D5−6930−01 TCGA−CM−6161−01 TCGA−CM−5862−01 TCGA−CM−4752−01 TCGA−CK−4947−01 TCGA−CA−6718−01 TCGA−CA−6717−01 TCGA−AZ−6598−01 TCGA−AY−6197−01 TCGA−AU−3779−01 TCGA−AG−A036−01 TCGA−AG−4007−01 TCGA−AG−3601−01 TCGA−AD−5900−01 TCGA−AA−A01D−01 TCGA−AA−3979−01 TCGA−AA−3972−01 TCGA−AA−3869−01 TCGA−AA−3866−01 TCGA−AA−3844−01 TCGA−AA−3815−01 TCGA−AA−3811−01 TCGA−AA−3663−01 TCGA−A6−5665−01 TCGA−A6−5656−01 TCGA−G5−6235−01 TCGA−G4−6626−01 TCGA−G4−6625−01 TCGA−G4−6586−01 TCGA−G4−6323−01 TCGA−G4−6321−01 TCGA−G4−6317−01 TCGA−G4−6310−01 TCGA−G4−6307−01 TCGA−G4−6306−01 TCGA−G4−6303−01 TCGA−G4−6299−01 TCGA−F5−6813−01 TCGA−F5−6812−01 TCGA−F5−6702−01 TCGA−F5−6571−01 TCGA−F4−6854−01 TCGA−F4−6808−01 TCGA−F4−6807−01 TCGA−F4−6806−01 TCGA−F4−6805−01 TCGA−F4−6704−01 TCGA−F4−6703−01 TCGA−F4−6460−01 TCGA−F4−6459−01 TCGA−EI−6510−01 TCGA−EI−6508−01 TCGA−EI−6507−01 TCGA−EI−6506−01 TCGA−EF−5830−01 TCGA−DY−A1DG−01 TCGA−DY−A1DF−01 TCGA−DY−A1DD−01 TCGA−DY−A1DC−01 TCGA−DT−5265−01 TCGA−DM−A28K−01 TCGA−DM−A28H−01 TCGA−DM−A28F−01 TCGA−DM−A28E−01 TCGA−DM−A285−01 TCGA−DM−A1HA−01 TCGA−DM−A1DB−01 TCGA−DM−A1DA−01 TCGA−DM−A1D9−01 TCGA−DM−A1D8−01 TCGA−DM−A1D7−01 TCGA−DM−A1D6−01 TCGA−DM−A1D4−01 TCGA−DM−A1D0−01 TCGA−DM−A0XF−01 TCGA−DM−A0XD−01 TCGA−DC−6683−01 TCGA−DC−6682−01 TCGA−DC−6158−01 TCGA−DC−6157−01 TCGA−DC−6155−01 TCGA−DC−5869−01 TCGA−DC−5337−01 TCGA−D5−6932−01 TCGA−D5−6931−01 TCGA−D5−6929−01 TCGA−D5−6926−01 TCGA−D5−6924−01 TCGA−D5−6923−01 TCGA−D5−6922−01 TCGA−D5−6920−01 TCGA−D5−6898−01 TCGA−D5−6541−01 TCGA−D5−6540−01 TCGA−D5−6539−01 TCGA−D5−6538−01 TCGA−D5−6535−01 TCGA−D5−6533−01 TCGA−D5−6532−01 TCGA−D5−5541−01 TCGA−D5−5540−01 TCGA−D5−5538−01 TCGA−CM−6679−01 TCGA−CM−6677−01 TCGA−CM−6676−01 TCGA−CM−6675−01 TCGA−CM−6172−01 TCGA−CM−6171−01 TCGA−CM−6169−01 TCGA−CM−6168−01 TCGA−CM−6166−01 TCGA−CM−6165−01 TCGA−CM−6164−01 TCGA−CM−6163−01 TCGA−CM−5868−01 TCGA−CM−5864−01 TCGA−CM−5860−01 TCGA−CM−5349−01 TCGA−CM−5348−01 TCGA−CM−5341−01 TCGA−CM−4746−01 TCGA−CM−4744−01 TCGA−CL−5918−01 TCGA−CL−5917−01 TCGA−CK−5914−01 TCGA−CK−4952−01 TCGA−CK−4950−01 TCGA−CK−4948−01 TCGA−CI−6624−01 TCGA−CI−6622−01 TCGA−CI−6621−01 TCGA−CI−6620−01 TCGA−CI−6619−01 TCGA−CA−6719−01 TCGA−CA−6716−01 TCGA−CA−5797−01 TCGA−AZ−6608−01 TCGA−AZ−6607−01 TCGA−AZ−6605−01 TCGA−AZ−6600−01 TCGA−AZ−6599−01 TCGA−AZ−5407−01 TCGA−AZ−5403−01 TCGA−AZ−4616−01 TCGA−AZ−4323−01 TCGA−AY−6196−01 TCGA−AY−5543−01 TCGA−AY−4071−01 TCGA−AY−4070−01 TCGA−AU−6004−01 TCGA−AH−6643−01 TCGA−AH−6544−01 TCGA−AG−A032−01 TCGA−AG−A02X−01 TCGA−AG−A02N−01 TCGA−AG−A026−01 TCGA−AG−A020−01 TCGA−AG−A01Y−01 TCGA−AG−A01W−01 TCGA−AG−A01L−01 TCGA−AG−A016−01 TCGA−AG−A014−01 TCGA−AG−A011−01 TCGA−AG−A00Y−01 TCGA−AG−A00C−01 TCGA−AG−4015−01 TCGA−AG−4008−01 TCGA−AG−4005−01 TCGA−AG−3999−01 TCGA−AG−3909−01 TCGA−AG−3902−01 TCGA−AG−3898−01 TCGA−AG−3896−01 TCGA−AG−3893−01 TCGA−AG−3890−01 TCGA−AG−3885−01 TCGA−AG−3882−01 TCGA−AG−3742−01 TCGA−AG−3732−01 TCGA−AG−3731−01 TCGA−AG−3726−01 TCGA−AG−3612−01 TCGA−AG−3611−01 TCGA−AG−3609−01 TCGA−AG−3608−01 TCGA−AG−3605−01 TCGA−AG−3602−01 TCGA−AG−3594−01 TCGA−AG−3587−01 TCGA−AG−3581−01 TCGA−AG−3578−01 TCGA−AG−3575−01 TCGA−AF−6672−01 TCGA−AF−6655−01 TCGA−AF−6136−01 TCGA−AF−4110−01 TCGA−AF−3913−01 TCGA−AF−3400−01 TCGA−AF−2693−01 TCGA−AF−2691−01 TCGA−AF−2689−01 TCGA−AF−2687−01 TCGA−AD−6965−01 TCGA−AD−6963−01 TCGA−AD−6901−01 TCGA−AD−6899−01 TCGA−AD−6888−01 TCGA−AD−6548−01 TCGA−AA−A03J−01 TCGA−AA−A02W−01 TCGA−AA−A02J−01 TCGA−AA−A02H−01 TCGA−AA−A02F−01 TCGA−AA−A01Z−01 TCGA−AA−A01T−01 TCGA−AA−A01S−01 TCGA−AA−A01K−01 TCGA−AA−A01G−01 TCGA−AA−A01F−01 TCGA−AA−A00W−01 TCGA−AA−A00L−01 TCGA−AA−A00F−01 TCGA−AA−A00E−01 TCGA−AA−A00D−01 TCGA−AA−3982−01 TCGA−AA−3980−01 TCGA−AA−3977−01 TCGA−AA−3976−01 TCGA−AA−3975−01 TCGA−AA−3956−01 TCGA−AA−3930−01 TCGA−AA−3875−01 TCGA−AA−3867−01 TCGA−AA−3860−01 TCGA−AA−3858−01 TCGA−AA−3856−01 TCGA−AA−3851−01 TCGA−AA−3848−01 TCGA−AA−3842−01 TCGA−AA−3814−01 TCGA−AA−3713−01 TCGA−AA−3712−01 TCGA−AA−3697−01 TCGA−AA−3693−01 TCGA−AA−3685−01 TCGA−AA−3681−01 TCGA−AA−3679−01 TCGA−AA−3667−01 TCGA−AA−3666−01 TCGA−AA−3662−01 TCGA−AA−3660−01 TCGA−AA−3655−01 TCGA−AA−3562−01 TCGA−AA−3561−01 TCGA−AA−3560−01 TCGA−AA−3558−01 TCGA−AA−3556−01 TCGA−AA−3553−01 TCGA−AA−3552−01 TCGA−AA−3549−01 TCGA−AA−3542−01 TCGA−AA−3531−01 TCGA−AA−3526−01 TCGA−AA−3524−01 TCGA−AA−3520−01 TCGA−AA−3519−01 TCGA−AA−3517−01 TCGA−AA−3511−01 TCGA−AA−3492−01 TCGA−A6−6782−01 TCGA−A6−6654−01 TCGA−A6−6652−01 TCGA−A6−6651−01 TCGA−A6−6649−01 TCGA−A6−6142−01 TCGA−A6−6138−01 TCGA−A6−6137−01 TCGA−A6−5662−01 TCGA−A6−5659−01 TCGA−A6−4105−01 TCGA−A6−3810−01 TCGA−A6−3807−01 TCGA−A6−2683−01 TCGA−A6−2678−01 TCGA−A6−2676−01 TCGA−A6−2674−01 TCGA−A6−2670−01

Constitutive Signaling By EGFRvIII FDR = 1.9e−12%, FDR nod = 0.00014%

KRAS

unknown CG mut

Activated Point Mutants Of FGFR2 Phospholipase C Mediated Cascade; FGFR2 FDR = 0.22%, FDR nod = 0.22%

wt wt PIK3R1

TCGA−AA−3543−01 TCGA−DM−A28E−01 TCGA−AA−A01Q−01 TCGA−CK−5913−01 TCGA−CI−6621−01 TCGA−AA−3710−01 TCGA−CM−6679−01 TCGA−A6−2676−01 TCGA−AG−3601−01 TCGA−AA−3949−01 TCGA−AA−3516−01 TCGA−A6−6781−01 TCGA−AA−3984−01 TCGA−G4−6309−01 TCGA−EI−6508−01 TCGA−D5−6922−01 TCGA−CM−6167−01 TCGA−AH−6549−01 TCGA−AA−3833−01 TCGA−AA−3664−01 TCGA−AA−3552−01 TCGA−DM−A1DA−01 TCGA−AA−3972−01 TCGA−DC−5337−01 TCGA−CA−5797−01 TCGA−AG−A01L−01 TCGA−AG−3894−01 TCGA−AF−3913−01 TCGA−AA−A02F−01 TCGA−AA−A024−01 TCGA−AA−A00F−01 TCGA−AA−3976−01 TCGA−AA−3973−01 TCGA−AA−3819−01 TCGA−AA−3666−01 TCGA−AA−3549−01 TCGA−A6−2678−01 TCGA−AG−A002−01 TCGA−D5−6533−01 TCGA−F5−6465−01 TCGA−DM−A28F−01 TCGA−AZ−6603−01 TCGA−AA−3968−01 TCGA−AA−3811−01 TCGA−AA−3518−01 TCGA−DY−A1DD−01 TCGA−D5−6928−01 TCGA−CM−6677−01 TCGA−CM−6170−01 TCGA−CK−6751−01 TCGA−CK−6748−01 TCGA−CK−5915−01 TCGA−AY−6196−01 TCGA−AA−A02K−01 TCGA−AA−A00R−01 TCGA−AA−A00E−01 TCGA−AA−3982−01 TCGA−AA−3966−01 TCGA−AA−3542−01 TCGA−AA−A010−01 TCGA−CM−6171−01 TCGA−G4−6315−01 TCGA−G4−6307−01 TCGA−CM−6162−01 TCGA−AD−5900−01 TCGA−AA−3662−01 TCGA−A6−6780−01 TCGA−G4−6588−01 TCGA−F5−6811−01 TCGA−F4−6460−01 TCGA−DY−A1DG−01 TCGA−DY−A0XA−01 TCGA−DC−6682−01 TCGA−D5−6898−01 TCGA−CM−6680−01 TCGA−CM−6676−01 TCGA−CM−6161−01 TCGA−CM−5861−01 TCGA−CM−5860−01 TCGA−CM−4752−01 TCGA−CK−5916−01 TCGA−CK−5914−01 TCGA−CA−6717−01 TCGA−AU−6004−01 TCGA−AU−3779−01 TCGA−AF−6136−01 TCGA−AF−2687−01 TCGA−AA−3712−01 TCGA−AA−3697−01 TCGA−A6−5660−01 TCGA−G4−6628−01 TCGA−G4−6317−01 TCGA−G4−6310−01 TCGA−G4−6304−01 TCGA−G4−6303−01 TCGA−G4−6299−01 TCGA−F4−6809−01 TCGA−F4−6808−01 TCGA−F4−6459−01 TCGA−DM−A28C−01 TCGA−D5−6926−01 TCGA−D5−6923−01 TCGA−D5−6920−01 TCGA−D5−6540−01 TCGA−D5−6534−01 TCGA−D5−5541−01 TCGA−CM−6172−01 TCGA−CM−6169−01 TCGA−CM−5864−01 TCGA−CM−5349−01 TCGA−CM−5344−01 TCGA−CK−6746−01 TCGA−CK−4952−01 TCGA−CA−6719−01 TCGA−AZ−5403−01 TCGA−AY−6197−01 TCGA−AA−A01V−01 TCGA−AA−3947−01 TCGA−AA−3850−01 TCGA−AA−3510−01 TCGA−AA−3492−01 TCGA−A6−5656−01 TCGA−A6−3809−01 TCGA−G4−6293−01 TCGA−F5−6813−01 TCGA−F4−6570−01 TCGA−F4−6569−01 TCGA−DY−A1DC−01 TCGA−DT−5265−01 TCGA−DM−A0XF−01 TCGA−DC−6158−01 TCGA−DC−6157−01 TCGA−DC−5869−01 TCGA−D5−6929−01 TCGA−CL−5918−01 TCGA−CK−6747−01 TCGA−CK−5912−01 TCGA−CI−6624−01 TCGA−CI−6619−01 TCGA−AZ−4682−01 TCGA−AH−6643−01 TCGA−AG−4015−01 TCGA−AF−2693−01 TCGA−AD−6963−01 TCGA−AD−6899−01 TCGA−AD−6890−01 TCGA−AA−3956−01 TCGA−AA−3950−01 TCGA−AA−3877−01 TCGA−AA−3866−01 TCGA−AA−3815−01 TCGA−AA−3812−01 TCGA−AA−3496−01 TCGA−AA−3489−01 TCGA−A6−6652−01 TCGA−A6−6649−01 TCGA−AZ−4315−01 TCGA−AD−6964−01 TCGA−AA−A00N−01 TCGA−DM−A1DB−01 TCGA−CM−5862−01 TCGA−AY−5543−01 TCGA−G4−6586−01 TCGA−EI−6507−01 TCGA−EF−5830−01 TCGA−DM−A1D9−01 TCGA−D5−6538−01 TCGA−D5−6536−01 TCGA−CM−6166−01 TCGA−CM−6164−01 TCGA−CM−4743−01 TCGA−AZ−6608−01 TCGA−AZ−6601−01 TCGA−AZ−5407−01 TCGA−AG−3742−01 TCGA−AA−3864−01 TCGA−AA−3663−01 TCGA−AA−3511−01 TCGA−A6−5665−01 TCGA−A6−5662−01 TCGA−G4−6625−01 TCGA−F4−6856−01 TCGA−DM−A285−01 TCGA−DM−A1D8−01 TCGA−DM−A0XD−01 TCGA−D5−6927−01 TCGA−D5−6539−01 TCGA−D5−6537−01 TCGA−D5−6532−01 TCGA−D5−5540−01 TCGA−D5−5539−01 TCGA−D5−5538−01 TCGA−CM−6674−01 TCGA−CM−6168−01 TCGA−CM−4746−01 TCGA−CK−4950−01 TCGA−CK−4948−01 TCGA−CK−4947−01 TCGA−CI−6622−01 TCGA−CA−6718−01 TCGA−AZ−6605−01 TCGA−AZ−6600−01 TCGA−AZ−6599−01 TCGA−AZ−6598−01 TCGA−AY−6386−01 TCGA−AG−3892−01 TCGA−AA−A01R−01 TCGA−AA−3977−01 TCGA−AA−3939−01 TCGA−AA−3715−01 TCGA−AA−3713−01 TCGA−A6−5666−01 TCGA−A6−5661−01 TCGA−A6−5659−01 TCGA−A6−5657−01 TCGA−A6−4105−01 TCGA−G5−6235−01 TCGA−G4−6626−01 TCGA−G4−6323−01 TCGA−G4−6306−01 TCGA−F5−6571−01 TCGA−F4−6855−01 TCGA−F4−6854−01 TCGA−F4−6807−01 TCGA−F4−6805−01 TCGA−F4−6703−01 TCGA−EI−6510−01 TCGA−DY−A1DF−01 TCGA−DM−A28K−01 TCGA−DM−A28H−01 TCGA−DM−A28G−01 TCGA−DM−A1HA−01 TCGA−DM−A1D7−01 TCGA−DM−A0X9−01 TCGA−DC−6683−01 TCGA−DC−6160−01 TCGA−D5−7000−01 TCGA−D5−6932−01 TCGA−D5−6931−01 TCGA−D5−6930−01 TCGA−D5−6541−01 TCGA−D5−6529−01 TCGA−CM−6678−01 TCGA−CM−4747−01 TCGA−CL−5917−01 TCGA−AZ−6606−01 TCGA−AZ−4616−01 TCGA−AH−6644−01 TCGA−AH−6544−01 TCGA−AG−A02N−01 TCGA−AG−A025−01 TCGA−AG−A020−01 TCGA−AG−A00H−01 TCGA−AG−3901−01 TCGA−AG−3887−01 TCGA−AG−3878−01 TCGA−AG−3731−01 TCGA−AG−3726−01 TCGA−AF−6672−01 TCGA−AF−2691−01 TCGA−AD−6965−01 TCGA−AD−6901−01 TCGA−AD−6895−01 TCGA−AD−6889−01 TCGA−AD−6548−01 TCGA−AA−A03J−01 TCGA−AA−A03F−01 TCGA−AA−A02Y−01 TCGA−AA−A02O−01 TCGA−AA−A01K−01 TCGA−AA−A01I−01 TCGA−AA−3979−01 TCGA−AA−3854−01 TCGA−AA−3852−01 TCGA−AA−3848−01 TCGA−AA−3837−01 TCGA−AA−3818−01 TCGA−AA−3696−01 TCGA−AA−3673−01 TCGA−AA−3660−01 TCGA−AA−3655−01 TCGA−AA−3558−01 TCGA−AA−3502−01 TCGA−A6−6782−01 TCGA−A6−6654−01 TCGA−A6−6653−01 TCGA−A6−6141−01 TCGA−A6−3808−01 TCGA−F5−6812−01 TCGA−F5−6702−01 TCGA−F4−6806−01 TCGA−EI−6506−01 TCGA−DY−A1H8−01 TCGA−DM−A282−01 TCGA−DM−A1D6−01 TCGA−DM−A1D4−01 TCGA−DM−A1D0−01 TCGA−DC−6155−01 TCGA−D5−6535−01 TCGA−D5−5537−01 TCGA−CM−6163−01 TCGA−CM−5863−01 TCGA−CM−4744−01 TCGA−CI−6620−01 TCGA−CA−6716−01 TCGA−CA−5796−01 TCGA−AZ−6607−01 TCGA−AG−A032−01 TCGA−AG−A02X−01 TCGA−AG−A01W−01 TCGA−AG−A015−01 TCGA−AG−A014−01 TCGA−AG−A00Y−01 TCGA−AG−A00C−01 TCGA−AG−A008−01 TCGA−AG−4008−01 TCGA−AG−4005−01 TCGA−AG−3999−01 TCGA−AG−3909−01 TCGA−AG−3902−01 TCGA−AG−3896−01 TCGA−AG−3885−01 TCGA−AG−3727−01 TCGA−AG−3611−01 TCGA−AG−3605−01 TCGA−AG−3602−01 TCGA−AG−3599−01 TCGA−AG−3594−01 TCGA−AG−3586−01 TCGA−AG−3583−01 TCGA−AG−3581−01 TCGA−AG−3580−01 TCGA−AG−3575−01 TCGA−AF−6655−01 TCGA−AF−5654−01 TCGA−AF−4110−01 TCGA−AF−2692−01 TCGA−AF−2689−01 TCGA−AA−A02W−01 TCGA−AA−A029−01 TCGA−AA−A01Z−01 TCGA−AA−A01X−01 TCGA−AA−A01G−01 TCGA−AA−A01F−01 TCGA−AA−A00Q−01 TCGA−AA−A00K−01 TCGA−AA−A00A−01 TCGA−AA−3994−01 TCGA−AA−3986−01 TCGA−AA−3975−01 TCGA−AA−3941−01 TCGA−AA−3930−01 TCGA−AA−3870−01 TCGA−AA−3851−01 TCGA−AA−3844−01 TCGA−AA−3842−01 TCGA−AA−3814−01 TCGA−AA−3695−01 TCGA−AA−3681−01 TCGA−AA−3680−01 TCGA−AA−3561−01 TCGA−AA−3560−01 TCGA−AA−3556−01 TCGA−AA−3555−01 TCGA−AA−3548−01 TCGA−AA−3532−01 TCGA−AA−3530−01 TCGA−AA−3522−01 TCGA−AA−3521−01 TCGA−AA−3520−01 TCGA−A6−6138−01 TCGA−A6−5664−01 TCGA−A6−2683−01

TCGA−DY−A1DC−01 TCGA−D5−6924−01 TCGA−F4−6703−01 TCGA−A6−6141−01 TCGA−CA−6718−01 TCGA−AA−3947−01 TCGA−D5−5538−01 TCGA−AU−6004−01 TCGA−CK−5916−01 TCGA−AY−6197−01 TCGA−G4−6293−01 TCGA−AA−3516−01 TCGA−AA−3502−01 TCGA−AA−A00N−01 TCGA−AA−3984−01 TCGA−D5−6920−01 TCGA−D5−5539−01 TCGA−AA−A01K−01 TCGA−G4−6309−01 TCGA−AA−A010−01 TCGA−CI−6622−01 TCGA−AG−A02N−01 TCGA−AA−3977−01 TCGA−CM−5861−01 TCGA−AD−6895−01 TCGA−F5−6813−01 TCGA−CM−6162−01 TCGA−AA−3949−01 TCGA−CM−6171−01 TCGA−AZ−4315−01 TCGA−AA−A01R−01 TCGA−F4−6856−01 TCGA−F4−6459−01 TCGA−D5−6930−01 TCGA−CM−6166−01 TCGA−CI−6621−01 TCGA−AD−6964−01 TCGA−AA−A01Q−01 TCGA−AA−3972−01 TCGA−AA−3864−01 TCGA−A6−6781−01 TCGA−A6−6653−01 TCGA−G4−6588−01 TCGA−CA−6717−01 TCGA−AZ−6601−01 TCGA−AG−A002−01 TCGA−G4−6628−01 TCGA−F5−6811−01 TCGA−D5−6898−01 TCGA−D5−6529−01 TCGA−CM−4743−01 TCGA−CK−4952−01 TCGA−AZ−6598−01 TCGA−AA−3713−01 TCGA−AA−3663−01 TCGA−AA−3510−01 TCGA−A6−5662−01 TCGA−G5−6235−01 TCGA−G4−6625−01 TCGA−G4−6323−01 TCGA−G4−6317−01 TCGA−G4−6304−01 TCGA−F4−6570−01 TCGA−EI−6506−01 TCGA−DY−A0XA−01 TCGA−DM−A28G−01 TCGA−DM−A28F−01 TCGA−DM−A1DB−01 TCGA−DM−A1D6−01 TCGA−DM−A0XF−01 TCGA−D5−6540−01 TCGA−D5−6539−01 TCGA−D5−6537−01 TCGA−D5−6535−01 TCGA−CM−6168−01 TCGA−CM−5862−01 TCGA−CM−5348−01 TCGA−CM−4752−01 TCGA−CK−4950−01 TCGA−AZ−6600−01 TCGA−AZ−6599−01 TCGA−AY−6386−01 TCGA−AY−6196−01 TCGA−AG−3892−01 TCGA−AF−6655−01 TCGA−AF−2693−01 TCGA−AD−6901−01 TCGA−AD−6889−01 TCGA−AA−3710−01 TCGA−AA−3660−01 TCGA−AA−3489−01 TCGA−A6−6142−01 TCGA−A6−6138−01 TCGA−A6−5666−01 TCGA−A6−5660−01

Cyclin A:Cdk2 Associated Events At S Phase Entry FDR = 1.9e−12%, FDR nod = 2.3e−11% Constitutive Signaling By Ligand Responsive EGFR Cancer Variants FDR = 1.9e−12%, FDR nod = 0.0019%

known HCG mut known HCG mut EGFR

known HCG mut FGF23

wt wt PPP1R13B

RIPK3 FAS

RIPK1 TNFRSF10C

TICAM2 TNFRSF10D

known HCG mut PLCG1

NRAS FGF5

PIK3R1 FGF6

SOS1 FGF3

GAB1 FGF18

SHC1 FGF10

FGF16

CBL FGF17

EGF FGF1

CDC37

HRAS FGF8

PLCG1 FGF9


RB1 KRAS

CCNA1 PIK3CA

SOS1

CDC25B

CDKN1B

GAB1

HSP90AA1

WEE1

SHC1

MYC

CBL

CDK2

CDC37

CCNA2

EGF

GRB2

HRAS

CDK7

MAX

PLCG1

FZR1

UBA52

CDKN1A

MNAT1

UBC

known HCG mut TLR3 known HCG mut TP63


IGFBP3

TICAM1

TLR4 TP53BP2

TNFRSF10A

TP73

CD14

TMEM219

FADD

TNFRSF10B

LY96

FGFR2

unknown CG mut

PIK3CA

EGFR

wt

wt

FGF2

FGF7

HSP90AA1

FGF20

FGF22

GRB2

NRAS

CCNH

CDC25A

TCGA−DC−6683−01 TCGA−AA−A01R−01 TCGA−AA−3712−01 TCGA−AA−3994−01 TCGA−AA−3864−01 TCGA−AA−A01V−01 TCGA−AA−A01T−01 TCGA−DM−A28K−01 TCGA−A6−5660−01 TCGA−A6−5659−01 TCGA−CM−5861−01 TCGA−CA−5254−01 TCGA−AA−A022−01 TCGA−AA−3821−01 TCGA−A6−6653−01 TCGA−D5−6928−01 TCGA−AG−A025−01 TCGA−AG−3892−01 TCGA−AA−3693−01 TCGA−AA−3492−01 TCGA−CA−6718−01 TCGA−AY−6196−01 TCGA−AA−3514−01 TCGA−A6−2672−01 TCGA−G4−6307−01 TCGA−CK−5913−01 TCGA−CK−5912−01 TCGA−AA−A00J−01 TCGA−A6−6648−01 TCGA−AA−A00R−01 TCGA−AA−3977−01 TCGA−G4−6628−01 TCGA−G4−6626−01 TCGA−F4−6569−01 TCGA−D5−6536−01 TCGA−CM−6168−01 TCGA−AZ−4315−01 TCGA−AA−3516−01 TCGA−A6−6781−01 TCGA−CM−6680−01 TCGA−AD−6963−01 TCGA−AA−3947−01 TCGA−AA−3860−01 TCGA−AA−3845−01 TCGA−CA−6717−01 TCGA−CM−6171−01 TCGA−CM−6162−01 TCGA−CK−4952−01 TCGA−AZ−6598−01 TCGA−AD−6895−01 TCGA−AA−3510−01 TCGA−A6−5661−01 TCGA−G4−6588−01 TCGA−G4−6315−01 TCGA−G4−6306−01 TCGA−G4−6304−01 TCGA−G4−6293−01 TCGA−F4−6570−01 TCGA−DY−A1H8−01 TCGA−DM−A28C−01 TCGA−D5−6540−01 TCGA−CM−6674−01 TCGA−CM−5348−01 TCGA−CM−5344−01 TCGA−CM−4743−01 TCGA−AZ−6601−01 TCGA−AZ−6599−01 TCGA−AU−6004−01 TCGA−AG−A002−01 TCGA−AA−A010−01 TCGA−AA−3715−01 TCGA−AA−3713−01 TCGA−AA−3662−01 TCGA−G4−6625−01 TCGA−G4−6586−01 TCGA−G4−6323−01 TCGA−G4−6321−01 TCGA−G4−6317−01 TCGA−G4−6299−01 TCGA−F5−6812−01 TCGA−F5−6464−01 TCGA−F4−6806−01 TCGA−EI−6510−01 TCGA−DY−A0XA−01 TCGA−DM−A28H−01 TCGA−DM−A28G−01 TCGA−DM−A28F−01 TCGA−DM−A1D4−01 TCGA−DM−A0XD−01 TCGA−D5−7000−01 TCGA−D5−6932−01 TCGA−D5−6927−01 TCGA−D5−6923−01 TCGA−D5−6898−01 TCGA−D5−6539−01 TCGA−D5−6535−01 TCGA−D5−6534−01 TCGA−D5−6533−01 TCGA−D5−6532−01 TCGA−D5−5539−01 TCGA−D5−5538−01 TCGA−CM−6678−01 TCGA−CM−6676−01 TCGA−CM−6172−01 TCGA−CM−6169−01 TCGA−CM−6165−01 TCGA−CM−6161−01 TCGA−CM−5860−01 TCGA−CM−5349−01 TCGA−CM−5341−01 TCGA−CM−4752−01 TCGA−CM−4747−01 TCGA−CK−4950−01 TCGA−CI−6620−01 TCGA−CI−6619−01 TCGA−CA−6719−01 TCGA−CA−5797−01 TCGA−AZ−6603−01 TCGA−AZ−6600−01 TCGA−AZ−4323−01 TCGA−AY−6197−01 TCGA−AU−3779−01 TCGA−AH−6549−01 TCGA−AG−3881−01 TCGA−AG−3742−01 TCGA−AF−6672−01 TCGA−AF−4110−01 TCGA−AF−2693−01 TCGA−AD−6901−01 TCGA−AD−6889−01 TCGA−AA−3968−01 TCGA−AA−3811−01 TCGA−AA−3697−01 TCGA−AA−3655−01 TCGA−AA−3502−01 TCGA−AA−3496−01 TCGA−A6−6780−01 TCGA−A6−6652−01 TCGA−A6−6649−01 TCGA−A6−6142−01 TCGA−A6−6141−01 TCGA−A6−5666−01 TCGA−A6−5665−01 TCGA−A6−5662−01 TCGA−A6−4105−01

TCGA−AA−3543−01 TCGA−DM−A28E−01 TCGA−AA−A01Q−01 TCGA−CK−5913−01 TCGA−AA−3710−01 TCGA−CI−6621−01 TCGA−CM−6679−01 TCGA−A6−2676−01 TCGA−AG−3601−01 TCGA−AA−3949−01 TCGA−AA−3516−01 TCGA−A6−6781−01 TCGA−AA−3984−01 TCGA−G4−6309−01 TCGA−EI−6508−01 TCGA−D5−6922−01 TCGA−CM−6167−01 TCGA−AH−6549−01 TCGA−AA−3833−01 TCGA−AA−3664−01 TCGA−AA−3552−01 TCGA−DM−A1DA−01 TCGA−AA−3972−01 TCGA−DC−5337−01 TCGA−CA−5797−01 TCGA−AG−A01L−01 TCGA−AG−3894−01 TCGA−AF−3913−01 TCGA−AA−A02F−01 TCGA−AA−A024−01 TCGA−AA−A00F−01 TCGA−AA−3976−01 TCGA−AA−3973−01 TCGA−AA−3819−01 TCGA−AA−3666−01 TCGA−AA−3549−01 TCGA−A6−2678−01 TCGA−AG−A002−01 TCGA−D5−6533−01 TCGA−F5−6465−01 TCGA−DM−A28F−01 TCGA−AZ−6603−01 TCGA−AA−3968−01 TCGA−AA−3811−01 TCGA−AA−3518−01 TCGA−DY−A1DD−01 TCGA−D5−6928−01 TCGA−CM−6677−01 TCGA−CM−6170−01 TCGA−CK−6751−01 TCGA−CK−6748−01 TCGA−CK−5915−01 TCGA−AY−6196−01 TCGA−AA−A02K−01 TCGA−AA−A00R−01 TCGA−AA−A00E−01 TCGA−AA−3982−01 TCGA−AA−3966−01 TCGA−AA−3542−01 TCGA−CM−6162−01 TCGA−AA−A010−01 TCGA−G4−6315−01 TCGA−CM−6171−01 TCGA−AD−5900−01 TCGA−G4−6307−01 TCGA−AA−3662−01 TCGA−A6−6780−01 TCGA−G4−6588−01 TCGA−F5−6811−01 TCGA−F4−6460−01 TCGA−DY−A1DG−01 TCGA−DY−A0XA−01 TCGA−DC−6682−01 TCGA−D5−6898−01 TCGA−D5−6540−01 TCGA−CM−6680−01 TCGA−CM−6676−01 TCGA−CM−6161−01 TCGA−CM−5861−01 TCGA−CM−5860−01 TCGA−CM−5349−01 TCGA−CM−4752−01 TCGA−CK−5916−01 TCGA−CK−5914−01 TCGA−CA−6717−01 TCGA−AU−6004−01 TCGA−AU−3779−01 TCGA−AF−6136−01 TCGA−AF−2687−01 TCGA−AA−3712−01 TCGA−AA−3697−01 TCGA−A6−5660−01 TCGA−G4−6628−01 TCGA−G4−6317−01 TCGA−G4−6310−01 TCGA−G4−6304−01 TCGA−G4−6303−01 TCGA−G4−6299−01 TCGA−F4−6809−01 TCGA−F4−6808−01 TCGA−F4−6459−01 TCGA−DM−A28C−01 TCGA−D5−6926−01 TCGA−D5−6923−01 TCGA−D5−6920−01 TCGA−D5−6534−01 TCGA−D5−5541−01 TCGA−CM−6172−01 TCGA−CM−6169−01 TCGA−CM−5864−01 TCGA−CM−5344−01 TCGA−CK−6746−01 TCGA−CK−4952−01 TCGA−CA−6719−01 TCGA−AZ−5403−01 TCGA−AY−6197−01 TCGA−AA−A01V−01 TCGA−AA−3947−01 TCGA−AA−3850−01 TCGA−AA−3510−01 TCGA−AA−3492−01 TCGA−A6−6652−01 TCGA−A6−5656−01 TCGA−A6−3809−01 TCGA−G4−6293−01 TCGA−F5−6813−01 TCGA−F4−6570−01 TCGA−F4−6569−01 TCGA−DY−A1DC−01 TCGA−DT−5265−01 TCGA−DM−A0XF−01 TCGA−DC−6158−01 TCGA−DC−6157−01 TCGA−DC−5869−01 TCGA−D5−6929−01 TCGA−CL−5918−01 TCGA−CK−6747−01 TCGA−CK−5912−01 TCGA−CI−6624−01 TCGA−CI−6619−01 TCGA−AZ−4682−01 TCGA−AH−6643−01 TCGA−AG−4015−01 TCGA−AF−2693−01 TCGA−AD−6963−01 TCGA−AD−6899−01 TCGA−AD−6890−01 TCGA−AA−3956−01 TCGA−AA−3950−01 TCGA−AA−3877−01 TCGA−AA−3866−01 TCGA−AA−3815−01 TCGA−AA−3812−01 TCGA−AA−3496−01 TCGA−AA−3489−01 TCGA−A6−6649−01 TCGA−AZ−4315−01 TCGA−AD−6964−01 TCGA−AA−A00N−01 TCGA−DM−A1DB−01 TCGA−CM−5862−01 TCGA−AY−5543−01 TCGA−G4−6586−01 TCGA−EI−6507−01 TCGA−EF−5830−01 TCGA−DM−A1D9−01 TCGA−D5−6538−01 TCGA−D5−6536−01 TCGA−CM−6166−01 TCGA−CM−6164−01 TCGA−CM−4743−01 TCGA−AZ−6608−01 TCGA−AZ−6601−01 TCGA−AZ−5407−01 TCGA−AG−3742−01 TCGA−AA−3864−01 TCGA−AA−3715−01 TCGA−AA−3663−01 TCGA−AA−3511−01 TCGA−A6−5665−01 TCGA−A6−5662−01 TCGA−G4−6625−01 TCGA−F4−6856−01 TCGA−DM−A285−01 TCGA−DM−A1D8−01 TCGA−DM−A0XD−01 TCGA−D5−6927−01 TCGA−D5−6539−01 TCGA−D5−6537−01 TCGA−D5−6532−01 TCGA−D5−5540−01 TCGA−D5−5539−01 TCGA−D5−5538−01 TCGA−CM−6674−01 TCGA−CM−6168−01 TCGA−CM−4746−01 TCGA−CK−4950−01 TCGA−CK−4948−01 TCGA−CK−4947−01 TCGA−CI−6622−01 TCGA−CA−6718−01 TCGA−AZ−6605−01 TCGA−AZ−6600−01 TCGA−AZ−6599−01 TCGA−AZ−6598−01 TCGA−AY−6386−01 TCGA−AG−3892−01 TCGA−AA−A01R−01 TCGA−AA−3977−01 TCGA−AA−3939−01 TCGA−AA−3713−01 TCGA−A6−5666−01 TCGA−A6−5661−01 TCGA−A6−5659−01 TCGA−A6−5657−01 TCGA−A6−4105−01 TCGA−G5−6235−01 TCGA−G4−6626−01 TCGA−G4−6323−01 TCGA−G4−6306−01 TCGA−F5−6812−01 TCGA−F5−6571−01 TCGA−F4−6855−01 TCGA−F4−6854−01 TCGA−F4−6807−01 TCGA−F4−6805−01 TCGA−F4−6703−01 TCGA−EI−6510−01 TCGA−DY−A1DF−01 TCGA−DM−A28K−01 TCGA−DM−A28H−01 TCGA−DM−A28G−01 TCGA−DM−A1HA−01 TCGA−DM−A1D7−01 TCGA−DM−A0X9−01 TCGA−DC−6683−01 TCGA−DC−6160−01 TCGA−D5−7000−01 TCGA−D5−6932−01 TCGA−D5−6931−01 TCGA−D5−6930−01 TCGA−D5−6541−01 TCGA−D5−6529−01 TCGA−CM−6678−01 TCGA−CM−4747−01 TCGA−CL−5917−01 TCGA−AZ−6606−01 TCGA−AZ−4616−01 TCGA−AH−6644−01 TCGA−AH−6544−01 TCGA−AG−A02N−01 TCGA−AG−A025−01 TCGA−AG−A020−01 TCGA−AG−A00H−01 TCGA−AG−3901−01 TCGA−AG−3887−01 TCGA−AG−3878−01 TCGA−AG−3731−01 TCGA−AG−3726−01 TCGA−AF−6672−01 TCGA−AF−2691−01 TCGA−AD−6965−01 TCGA−AD−6901−01 TCGA−AD−6895−01 TCGA−AD−6889−01 TCGA−AD−6548−01 TCGA−AA−A03J−01 TCGA−AA−A03F−01 TCGA−AA−A02Y−01 TCGA−AA−A02O−01 TCGA−AA−A01K−01 TCGA−AA−A01I−01 TCGA−AA−3979−01 TCGA−AA−3854−01 TCGA−AA−3852−01 TCGA−AA−3848−01 TCGA−AA−3837−01 TCGA−AA−3818−01 TCGA−AA−3696−01 TCGA−AA−3673−01 TCGA−AA−3660−01 TCGA−AA−3655−01 TCGA−AA−3558−01 TCGA−AA−3502−01 TCGA−A6−6782−01 TCGA−A6−6654−01 TCGA−A6−6653−01 TCGA−A6−6141−01 TCGA−A6−3808−01 TCGA−F5−6702−01 TCGA−F4−6806−01 TCGA−EI−6506−01 TCGA−DY−A1H8−01 TCGA−DM−A282−01 TCGA−DM−A1D6−01 TCGA−DM−A1D4−01 TCGA−DM−A1D0−01 TCGA−DC−6155−01 TCGA−D5−6535−01 TCGA−D5−5537−01 TCGA−CM−6163−01 TCGA−CM−5863−01 TCGA−CM−4744−01 TCGA−CI−6620−01 TCGA−CA−6716−01 TCGA−CA−5796−01 TCGA−AZ−6607−01 TCGA−AG−A032−01 TCGA−AG−A02X−01 TCGA−AG−A01W−01 TCGA−AG−A015−01 TCGA−AG−A014−01 TCGA−AG−A00Y−01 TCGA−AG−A00C−01 TCGA−AG−A008−01 TCGA−AG−4008−01 TCGA−AG−4005−01 TCGA−AG−3999−01 TCGA−AG−3909−01 TCGA−AG−3902−01 TCGA−AG−3896−01 TCGA−AG−3885−01 TCGA−AG−3727−01 TCGA−AG−3611−01 TCGA−AG−3605−01 TCGA−AG−3602−01 TCGA−AG−3599−01 TCGA−AG−3594−01 TCGA−AG−3586−01 TCGA−AG−3583−01 TCGA−AG−3581−01 TCGA−AG−3580−01 TCGA−AG−3575−01 TCGA−AF−6655−01 TCGA−AF−5654−01 TCGA−AF−4110−01 TCGA−AF−2692−01 TCGA−AF−2689−01 TCGA−AA−A02W−01 TCGA−AA−A029−01 TCGA−AA−A01Z−01 TCGA−AA−A01X−01 TCGA−AA−A01G−01 TCGA−AA−A01F−01 TCGA−AA−A00Q−01 TCGA−AA−A00K−01 TCGA−AA−A00A−01 TCGA−AA−3994−01 TCGA−AA−3986−01 TCGA−AA−3975−01 TCGA−AA−3941−01 TCGA−AA−3930−01 TCGA−AA−3870−01 TCGA−AA−3851−01 TCGA−AA−3844−01 TCGA−AA−3842−01 TCGA−AA−3814−01 TCGA−AA−3695−01 TCGA−AA−3681−01 TCGA−AA−3680−01 TCGA−AA−3561−01 TCGA−AA−3560−01 TCGA−AA−3556−01 TCGA−AA−3555−01 TCGA−AA−3548−01 TCGA−AA−3532−01 TCGA−AA−3530−01 TCGA−AA−3522−01 TCGA−AA−3521−01 TCGA−AA−3520−01 TCGA−A6−6138−01 TCGA−A6−5664−01 TCGA−A6−2683−01

ErbB Receptor Signaling Network FDR = 2e−12%, FDR nod = 2.3e−11% Energy Dependent Regulation Of MTOR By LKB1 AMPK FDR = 4.4%, FDR nod = 3.2%

TCGA−AA−3855−01 TCGA−AA−A01D−01 TCGA−AG−A02G−01 TCGA−AF−6136−01 TCGA−A6−2676−01 TCGA−EI−6507−01 TCGA−D5−6926−01 TCGA−AA−3939−01 TCGA−CI−6621−01 TCGA−AZ−6605−01 TCGA−AA−3710−01 TCGA−A6−5659−01 TCGA−D5−6540−01 TCGA−CA−6718−01 TCGA−AG−4007−01 TCGA−AG−3878−01 TCGA−AA−3555−01 TCGA−AZ−4315−01 TCGA−AG−3892−01 TCGA−A6−6781−01 TCGA−A6−5661−01 TCGA−DM−A282−01 TCGA−AG−A00Y−01 TCGA−AG−3883−01 TCGA−AA−3696−01 TCGA−AA−3525−01 TCGA−A6−6653−01 TCGA−A6−6141−01 TCGA−CM−6171−01 TCGA−A6−4105−01 TCGA−D5−6927−01 TCGA−AH−6644−01 TCGA−AA−3977−01 TCGA−A6−6138−01 TCGA−F4−6855−01 TCGA−DM−A0XF−01 TCGA−D5−6532−01 TCGA−CM−6675−01 TCGA−AG−3902−01 TCGA−AG−3898−01 TCGA−AG−3732−01 TCGA−AF−2693−01 TCGA−AD−6888−01 TCGA−AA−3994−01 TCGA−AA−3869−01 TCGA−AA−3660−01 TCGA−G4−6304−01 TCGA−F5−6464−01 TCGA−CM−5349−01 TCGA−CM−5348−01 TCGA−CK−4947−01 TCGA−AY−6197−01 TCGA−AG−3600−01 TCGA−AA−3950−01 TCGA−A6−5657−01 TCGA−F4−6856−01 TCGA−D5−6931−01 TCGA−CM−4746−01 TCGA−AG−3726−01 TCGA−AD−6890−01 TCGA−AA−A022−01 TCGA−AA−A00A−01 TCGA−AA−3976−01 TCGA−AA−3819−01 TCGA−AA−3715−01 TCGA−AA−3695−01 TCGA−AA−3672−01 TCGA−AA−3519−01 TCGA−AA−A010−01 TCGA−AA−3864−01 TCGA−AA−3947−01 TCGA−AA−3713−01 TCGA−AA−3510−01 TCGA−AH−6544−01 TCGA−AG−A02N−01 TCGA−AG−3599−01 TCGA−AA−A01Q−01 TCGA−AA−3984−01 TCGA−A6−2672−01 TCGA−F4−6703−01 TCGA−F4−6459−01 TCGA−EI−6510−01 TCGA−DM−A1DA−01 TCGA−D5−6932−01 TCGA−D5−6541−01 TCGA−D5−5538−01 TCGA−CM−6172−01 TCGA−CM−6167−01 TCGA−CM−6163−01 TCGA−CM−5861−01 TCGA−CM−4743−01 TCGA−CK−6746−01 TCGA−CK−5913−01 TCGA−CK−4948−01 TCGA−AZ−6608−01 TCGA−AZ−4616−01 TCGA−AY−4071−01 TCGA−AG−3581−01 TCGA−AF−4110−01 TCGA−AD−6899−01 TCGA−AD−6895−01 TCGA−AA−3875−01 TCGA−AA−3861−01 TCGA−AA−3850−01 TCGA−AA−3818−01 TCGA−AA−3815−01 TCGA−AA−3814−01 TCGA−A6−6649−01 TCGA−A6−6137−01 TCGA−A6−5665−01 TCGA−AG−A002−01 TCGA−CA−6717−01 TCGA−D5−6928−01 TCGA−G4−6588−01 TCGA−AZ−6601−01 TCGA−AA−A01R−01 TCGA−AA−3966−01 TCGA−G4−6307−01 TCGA−G4−6303−01 TCGA−DY−A1DG−01 TCGA−DM−A285−01 TCGA−DM−A1DB−01 TCGA−DM−A1D8−01 TCGA−D5−6898−01 TCGA−D5−6539−01 TCGA−D5−6534−01 TCGA−D5−5540−01 TCGA−CM−6680−01 TCGA−CM−6170−01 TCGA−CM−6162−01 TCGA−CM−5860−01 TCGA−AZ−6600−01 TCGA−AZ−6599−01 TCGA−AZ−6598−01 TCGA−AY−5543−01 TCGA−AD−6964−01 TCGA−AD−5900−01 TCGA−AA−A00R−01 TCGA−AA−A00N−01 TCGA−AA−A00E−01 TCGA−AA−3982−01 TCGA−AA−3663−01 TCGA−AA−3502−01 TCGA−A6−5660−01 TCGA−G4−6317−01 TCGA−G4−6315−01 TCGA−G4−6306−01 TCGA−G4−6299−01 TCGA−F5−6465−01 TCGA−F4−6809−01 TCGA−F4−6808−01 TCGA−F4−6460−01 TCGA−EF−5830−01 TCGA−DY−A1DF−01 TCGA−DY−A1DD−01 TCGA−DY−A0XA−01 TCGA−DM−A28F−01 TCGA−D5−6920−01 TCGA−D5−6538−01 TCGA−D5−6537−01 TCGA−D5−6536−01 TCGA−D5−6533−01 TCGA−D5−5539−01 TCGA−CM−6677−01 TCGA−CM−6676−01 TCGA−CM−6169−01 TCGA−CM−6168−01 TCGA−CM−6166−01 TCGA−CM−5862−01 TCGA−CM−5344−01 TCGA−CK−6751−01 TCGA−CK−6748−01 TCGA−CK−5915−01 TCGA−CK−5914−01 TCGA−AZ−6603−01 TCGA−AZ−5407−01 TCGA−AZ−5403−01 TCGA−AY−6196−01 TCGA−AU−6004−01 TCGA−AU−3779−01 TCGA−AG−3742−01 TCGA−AF−2687−01 TCGA−AD−6901−01 TCGA−AA−A02K−01 TCGA−AA−3968−01 TCGA−AA−3811−01 TCGA−AA−3712−01 TCGA−AA−3697−01 TCGA−AA−3542−01 TCGA−AA−3518−01 TCGA−A6−3809−01

TCGA−AA−3556−01 TCGA−AA−A01D−01 TCGA−AA−3542−01 TCGA−AA−A022−01 TCGA−AZ−5403−01 TCGA−DM−A28H−01 TCGA−AG−A01W−01 TCGA−CM−6164−01 TCGA−AA−3977−01 TCGA−AA−A01Q−01 TCGA−AG−3584−01 TCGA−G4−6625−01 TCGA−F5−6813−01 TCGA−AZ−6599−01 TCGA−CM−5862−01 TCGA−G4−6628−01 TCGA−A6−2676−01 TCGA−DY−A1DD−01 TCGA−CM−6165−01 TCGA−AA−3679−01 TCGA−DY−A1DG−01 TCGA−DM−A1HA−01 TCGA−AA−3844−01 TCGA−AA−3510−01 TCGA−D5−6927−01 TCGA−AA−3672−01 TCGA−AA−3864−01 TCGA−AF−6136−01 TCGA−AA−3947−01 TCGA−G4−6588−01 TCGA−A6−5661−01 TCGA−A6−6653−01 TCGA−D5−6538−01 TCGA−D5−6535−01 TCGA−AA−3558−01 TCGA−A6−5662−01 TCGA−CM−6162−01 TCGA−AD−5900−01 TCGA−CK−4952−01 TCGA−D5−6537−01 TCGA−D5−5541−01 TCGA−AD−6548−01 TCGA−AA−3950−01 TCGA−CA−6717−01 TCGA−AZ−4315−01 TCGA−AA−A00N−01 TCGA−A6−6780−01 TCGA−F5−6465−01 TCGA−CM−6674−01 TCGA−AG−A025−01 TCGA−AA−A00A−01 TCGA−AA−3858−01 TCGA−AA−3837−01 TCGA−CK−6746−01 TCGA−AY−6196−01 TCGA−F4−6855−01 TCGA−DY−A0XA−01 TCGA−D5−6539−01 TCGA−D5−6536−01 TCGA−CK−6748−01 TCGA−AZ−6600−01 TCGA−AD−6889−01 TCGA−AA−3712−01 TCGA−AA−3696−01 TCGA−A6−6138−01 TCGA−AD−6964−01 TCGA−F4−6856−01 TCGA−F4−6703−01 TCGA−DY−A1DF−01 TCGA−DM−A1D9−01 TCGA−CK−5913−01 TCGA−AG−A02N−01 TCGA−AA−A01R−01 TCGA−AA−A00J−01 TCGA−AA−3815−01 TCGA−F5−6571−01 TCGA−D5−6931−01 TCGA−D5−5540−01 TCGA−CM−6171−01 TCGA−CM−4746−01 TCGA−AA−A03F−01 TCGA−AA−A00U−01 TCGA−A6−2677−01 TCGA−AA−3492−01 TCGA−CK−5916−01 TCGA−D5−6923−01 TCGA−CM−5349−01 TCGA−CM−5348−01 TCGA−CM−4743−01 TCGA−AZ−5407−01 TCGA−AU−3779−01 TCGA−AD−6895−01 TCGA−AA−3713−01 TCGA−A6−5665−01 TCGA−G4−6626−01 TCGA−G4−6315−01 TCGA−G4−6310−01 TCGA−G4−6293−01 TCGA−DM−A0XF−01 TCGA−DC−5337−01 TCGA−D5−6533−01 TCGA−D5−5539−01 TCGA−D5−5537−01 TCGA−CM−5344−01 TCGA−CK−5915−01 TCGA−CK−4950−01 TCGA−CI−6624−01 TCGA−CA−6719−01 TCGA−AA−3662−01 TCGA−AA−3660−01 TCGA−AA−3496−01 TCGA−AG−A002−01 TCGA−AY−6197−01 TCGA−AA−A010−01 TCGA−AY−5543−01 TCGA−AA−3715−01 TCGA−AZ−6601−01 TCGA−AZ−6598−01 TCGA−AU−6004−01 TCGA−AA−3984−01 TCGA−AA−3877−01 TCGA−G4−6586−01 TCGA−F4−6570−01 TCGA−DT−5265−01 TCGA−DM−A282−01 TCGA−CM−4752−01 TCGA−A6−6781−01 TCGA−A6−4105−01 TCGA−G4−6309−01 TCGA−G4−6307−01 TCGA−F4−6806−01 TCGA−EF−5830−01 TCGA−DM−A28K−01 TCGA−DM−A1D4−01 TCGA−CA−6716−01 TCGA−AG−3892−01 TCGA−AA−A00K−01 TCGA−AA−3980−01 TCGA−AA−3956−01 TCGA−AA−3949−01 TCGA−AA−3867−01 TCGA−AA−3854−01 TCGA−AA−3821−01 TCGA−AA−3710−01 TCGA−AA−3666−01 TCGA−AA−3663−01 TCGA−AA−3555−01 TCGA−A6−6651−01 TCGA−A6−6141−01 TCGA−A6−5666−01

ERBB2 Regulates Cell Motility FDR = 1.9e−12%, FDR nod = 5.5e−11%

EGFR

unknown CG mut

ERBB2 Activates PTK6 Signaling Signaling By ERBB4 FDR = 1.9e−12%, FDR nod = 2.3e−11%

TCGA−AA−3855−01 TCGA−AG−4001−01 TCGA−AA−A01D−01 TCGA−AG−A02G−01 TCGA−AF−6136−01 TCGA−A6−2676−01 TCGA−EI−6507−01 TCGA−D5−6926−01 TCGA−AA−3939−01 TCGA−D5−6540−01 TCGA−CA−6718−01 TCGA−AG−4007−01 TCGA−AG−3878−01 TCGA−AA−3555−01 TCGA−CK−4950−01 TCGA−G4−6310−01 TCGA−CM−6678−01 TCGA−AA−A01P−01 TCGA−AA−3972−01 TCGA−AA−3845−01 TCGA−AG−3892−01 TCGA−A6−5661−01 TCGA−AZ−4315−01 TCGA−DM−A282−01 TCGA−AG−A00Y−01 TCGA−AG−3883−01 TCGA−AA−3696−01 TCGA−AA−3525−01 TCGA−A6−6781−01 TCGA−A6−6653−01 TCGA−A6−6141−01 TCGA−CM−6171−01 TCGA−AA−3977−01 TCGA−D5−6927−01 TCGA−AH−6644−01 TCGA−A6−6138−01 TCGA−A6−4105−01 TCGA−F4−6855−01 TCGA−DM−A0XF−01 TCGA−D5−6532−01 TCGA−CM−6675−01 TCGA−AG−3902−01 TCGA−AG−3898−01 TCGA−AG−3732−01 TCGA−AF−2693−01 TCGA−AD−6888−01 TCGA−AA−3994−01 TCGA−AA−3869−01 TCGA−AA−3660−01 TCGA−G4−6304−01 TCGA−F5−6464−01 TCGA−CM−5349−01 TCGA−CM−5348−01 TCGA−CK−4947−01 TCGA−AY−6197−01 TCGA−AG−3600−01 TCGA−AA−3950−01 TCGA−A6−5657−01 TCGA−F4−6856−01 TCGA−D5−6931−01 TCGA−CM−4746−01 TCGA−AG−3726−01 TCGA−AD−6890−01 TCGA−AA−A022−01 TCGA−AA−A00A−01 TCGA−AA−3976−01 TCGA−AA−3819−01 TCGA−AA−3715−01 TCGA−AA−3695−01 TCGA−AA−3672−01 TCGA−AA−3519−01 TCGA−AA−A010−01 TCGA−AA−3864−01 TCGA−AA−3947−01 TCGA−AA−3713−01 TCGA−AA−3510−01 TCGA−CM−6172−01 TCGA−CK−4948−01 TCGA−AH−6544−01 TCGA−AG−A02N−01 TCGA−AG−3599−01 TCGA−AD−6895−01 TCGA−AA−A01Q−01 TCGA−AA−3984−01 TCGA−A6−5665−01 TCGA−A6−2672−01 TCGA−F4−6703−01 TCGA−F4−6459−01 TCGA−EI−6510−01 TCGA−DM−A1DA−01 TCGA−D5−6932−01 TCGA−D5−6541−01 TCGA−D5−5538−01 TCGA−CM−6167−01 TCGA−CM−6163−01 TCGA−CM−5861−01 TCGA−CM−4743−01 TCGA−CK−6746−01 TCGA−CK−5913−01 TCGA−AZ−6608−01 TCGA−AZ−4616−01 TCGA−AY−4071−01 TCGA−AG−3581−01 TCGA−AF−4110−01 TCGA−AD−6899−01 TCGA−AA−3875−01 TCGA−AA−3861−01 TCGA−AA−3850−01 TCGA−AA−3818−01 TCGA−AA−3815−01 TCGA−AA−3814−01 TCGA−A6−6649−01 TCGA−A6−6137−01 TCGA−AG−A002−01 TCGA−CA−6717−01 TCGA−D5−6928−01 TCGA−AA−A01R−01 TCGA−G4−6588−01 TCGA−DM−A1D8−01 TCGA−AZ−6601−01 TCGA−AZ−6598−01 TCGA−AD−6964−01 TCGA−AA−3966−01 TCGA−G4−6307−01 TCGA−G4−6303−01 TCGA−DY−A1DG−01 TCGA−DM−A285−01 TCGA−DM−A1DB−01 TCGA−D5−6898−01 TCGA−D5−6539−01 TCGA−D5−6536−01 TCGA−D5−6534−01 TCGA−D5−5540−01 TCGA−CM−6680−01 TCGA−CM−6170−01 TCGA−CM−6162−01 TCGA−CM−5860−01 TCGA−AZ−6600−01 TCGA−AZ−6599−01 TCGA−AY−5543−01 TCGA−AD−5900−01 TCGA−AA−A00R−01 TCGA−AA−A00N−01 TCGA−AA−A00E−01 TCGA−AA−3982−01 TCGA−AA−3663−01 TCGA−AA−3502−01 TCGA−A6−5660−01 TCGA−G4−6317−01 TCGA−G4−6315−01 TCGA−G4−6306−01 TCGA−G4−6299−01 TCGA−F5−6465−01 TCGA−F4−6809−01 TCGA−F4−6808−01 TCGA−F4−6460−01 TCGA−EF−5830−01 TCGA−DY−A1DF−01 TCGA−DY−A1DD−01 TCGA−DY−A0XA−01 TCGA−DM−A28F−01 TCGA−D5−6920−01 TCGA−D5−6538−01 TCGA−D5−6537−01 TCGA−D5−6533−01 TCGA−D5−5539−01 TCGA−CM−6677−01 TCGA−CM−6676−01 TCGA−CM−6169−01 TCGA−CM−6168−01 TCGA−CM−6166−01 TCGA−CM−5862−01 TCGA−CM−5344−01 TCGA−CK−6751−01 TCGA−CK−6748−01 TCGA−CK−5915−01 TCGA−CK−5914−01 TCGA−AZ−6603−01 TCGA−AZ−5407−01 TCGA−AZ−5403−01 TCGA−AY−6196−01 TCGA−AU−6004−01 TCGA−AU−3779−01 TCGA−AG−3742−01 TCGA−AF−2687−01 TCGA−AD−6901−01 TCGA−AA−A02K−01 TCGA−AA−3968−01 TCGA−AA−3811−01 TCGA−AA−3712−01 TCGA−AA−3697−01 TCGA−AA−3542−01 TCGA−AA−3518−01 TCGA−A6−3809−01

TCGA−AA−3492−01 TCGA−AA−3855−01 TCGA−AA−A01D−01 TCGA−AG−A02G−01 TCGA−AF−6136−01 TCGA−A6−2676−01 TCGA−EI−6507−01 TCGA−D5−6926−01 TCGA−AA−3939−01 TCGA−D5−6540−01 TCGA−CA−6718−01 TCGA−AG−4007−01 TCGA−AG−3878−01 TCGA−AA−3555−01 TCGA−AZ−4315−01 TCGA−AG−3892−01 TCGA−A6−5661−01 TCGA−DM−A282−01 TCGA−AG−A00Y−01 TCGA−AG−3883−01 TCGA−AA−3696−01 TCGA−AA−3525−01 TCGA−A6−6781−01 TCGA−A6−6653−01 TCGA−A6−6141−01 TCGA−CM−6171−01 TCGA−D5−6927−01 TCGA−AH−6644−01 TCGA−AA−3977−01 TCGA−A6−6138−01 TCGA−A6−4105−01 TCGA−F4−6855−01 TCGA−DM−A0XF−01 TCGA−D5−6532−01 TCGA−CM−6675−01 TCGA−AG−3902−01 TCGA−AG−3898−01 TCGA−AG−3732−01 TCGA−AF−2693−01 TCGA−AD−6888−01 TCGA−AA−3994−01 TCGA−AA−3869−01 TCGA−AA−3660−01 TCGA−G4−6304−01 TCGA−F5−6464−01 TCGA−CM−5349−01 TCGA−CM−5348−01 TCGA−CK−4947−01 TCGA−AY−6197−01 TCGA−AG−3600−01 TCGA−AA−3950−01 TCGA−A6−5657−01 TCGA−F4−6856−01 TCGA−D5−6931−01 TCGA−CM−4746−01 TCGA−AG−3726−01 TCGA−AD−6890−01 TCGA−AA−A022−01 TCGA−AA−A00A−01 TCGA−AA−3976−01 TCGA−AA−3819−01 TCGA−AA−3715−01 TCGA−AA−3695−01 TCGA−AA−3672−01 TCGA−AA−3519−01 TCGA−AA−A010−01 TCGA−AA−3864−01 TCGA−AA−3947−01 TCGA−AA−3713−01 TCGA−AA−3510−01 TCGA−AH−6544−01 TCGA−AG−A02N−01 TCGA−AG−3599−01 TCGA−AA−A01Q−01 TCGA−AA−3984−01 TCGA−A6−2672−01 TCGA−F4−6703−01 TCGA−F4−6459−01 TCGA−EI−6510−01 TCGA−DM−A1DA−01 TCGA−D5−6932−01 TCGA−D5−6541−01 TCGA−D5−5538−01 TCGA−CM−6172−01 TCGA−CM−6167−01 TCGA−CM−6163−01 TCGA−CM−5861−01 TCGA−CM−4743−01 TCGA−CK−6746−01 TCGA−CK−5913−01 TCGA−CK−4948−01 TCGA−AZ−6608−01 TCGA−AZ−4616−01 TCGA−AY−4071−01 TCGA−AG−3581−01 TCGA−AF−4110−01 TCGA−AD−6899−01 TCGA−AD−6895−01 TCGA−AA−3875−01 TCGA−AA−3861−01 TCGA−AA−3850−01 TCGA−AA−3818−01 TCGA−AA−3815−01 TCGA−AA−3814−01 TCGA−A6−6649−01 TCGA−A6−6137−01 TCGA−A6−5665−01 TCGA−CA−6717−01 TCGA−AG−A002−01 TCGA−D5−6928−01 TCGA−AZ−6601−01 TCGA−G4−6588−01 TCGA−AA−A01R−01 TCGA−AA−3966−01 TCGA−G4−6307−01 TCGA−G4−6303−01 TCGA−DY−A1DG−01 TCGA−DM−A285−01 TCGA−DM−A1DB−01 TCGA−DM−A1D8−01 TCGA−D5−6898−01 TCGA−D5−6539−01 TCGA−D5−6538−01 TCGA−D5−6534−01 TCGA−D5−5540−01 TCGA−CM−6680−01 TCGA−CM−6170−01 TCGA−CM−6162−01 TCGA−CM−5860−01 TCGA−AZ−6600−01 TCGA−AZ−6599−01 TCGA−AZ−6598−01 TCGA−AY−5543−01 TCGA−AD−6964−01 TCGA−AD−5900−01 TCGA−AA−A00R−01 TCGA−AA−A00N−01 TCGA−AA−A00E−01 TCGA−AA−3982−01 TCGA−AA−3663−01 TCGA−AA−3502−01 TCGA−A6−5660−01 TCGA−G4−6317−01 TCGA−G4−6315−01 TCGA−G4−6306−01 TCGA−G4−6299−01 TCGA−F5−6465−01 TCGA−F4−6809−01 TCGA−F4−6808−01 TCGA−F4−6460−01 TCGA−EF−5830−01 TCGA−DY−A1DF−01 TCGA−DY−A1DD−01 TCGA−DY−A0XA−01 TCGA−DM−A28F−01 TCGA−D5−6920−01 TCGA−D5−6537−01 TCGA−D5−6536−01 TCGA−D5−6533−01 TCGA−D5−5539−01 TCGA−CM−6677−01 TCGA−CM−6676−01 TCGA−CM−6169−01 TCGA−CM−6168−01 TCGA−CM−6166−01 TCGA−CM−5862−01 TCGA−CM−5344−01 TCGA−CK−6751−01 TCGA−CK−6748−01 TCGA−CK−5915−01 TCGA−CK−5914−01 TCGA−AZ−6603−01 TCGA−AZ−5407−01 TCGA−AZ−5403−01 TCGA−AY−6196−01 TCGA−AU−6004−01 TCGA−AU−3779−01 TCGA−AG−3742−01 TCGA−AF−2687−01 TCGA−AD−6901−01 TCGA−AA−A02K−01 TCGA−AA−3968−01 TCGA−AA−3811−01 TCGA−AA−3712−01 TCGA−AA−3697−01 TCGA−AA−3542−01 TCGA−AA−3518−01 TCGA−A6−3809−01

ErbB4 Signaling Events FDR = 1.9e−12%, FDR nod = 3.6e−06% ErbB2/ErbB3 Signaling Events FDR = 1.9e−12%, FDR nod = 1.1e−09%

ERBB3 TSC1

NRG1 PRKAA1

NRG3 PRKAG1

HSP90AA1 RHEB

PRKAG3

EGF STRADB

NRG2 LAMTOR4

BTC RRAGB

EREG LAMTOR1

HBEGF MLST8

NRG4 RRAGA

ERBB4 EGFR

ERBB3 ERBB4

ERBB2 ERBB3

NRG1 ERBB2

RHOA NRG1

EREG EREG

HBEGF

HBEGF PTK6

NRG4

NEDD4

PIK3CB

WWOX

WWP1

NRG2

PRLR

SHC1

STAT5A

BTC

DLG4

ITCH

LRIG1

MAPK1

MAPK3

NRG3

NRG4

PRL

CBFA2T3

EREG

GRB2

HBEGF

MDM2

STAT5B

TAB2

YAP1

wt GRIN2B wt

known HCG mut NRG1 known HCG mut

unknown CG mut PIK3CA unknown CG mut

ERBB4

ERBB2

PIK3R1

JAK2

NCOR1

ADAM17

FYN

KRAS PIK3CA NRAS JAK2 NF2 ERBB3 MTOR MAPK10 NRG1 PIK3R1 PTPN11 CHRNE DOCK7 ERBB2 NRG2 SHC1 CHRNA1 GRB2 MAPK8 NFATC4 RAF1 SOS1 AKT1 BAD CDC42 FOS HRAS JUN MAP2K1 MAP2K2 MAPK1 MAPK3 MAPK9 PIK3CB PPP3CB PRKACA RAC1 RNF41 SRC STAT3 USP8

EGFR STK11

wt ERBB2 wt CAB39L


ERBB4 TSC2

unknown CG mut MTOR

unknown CG mut

RPTOR

PRKAA2

RRAGD

PPM1A

PRKAB1

PRKAG2

RRAGC

LAMTOR2

LAMTOR5

CAB39

LAMTOR3

PRKAB2

STRADA

unknown CG mut

known HCG mut

known HCG mut

wt

wt

NRG3

EGF

NRG3

EGF

NRG2

NRG2

BTC

BTC

NRG4

MEMO1

DIAPH1

TCGA−AA−3930−01 TCGA−AA−3858−01 TCGA−AA−3855−01 TCGA−AG−4007−01 TCGA−AG−A032−01 TCGA−AA−3870−01 TCGA−AA−3562−01 TCGA−F4−6806−01 TCGA−CM−4744−01 TCGA−AA−A01D−01 TCGA−D5−6930−01 TCGA−D5−5537−01 TCGA−AA−3979−01 TCGA−AA−3811−01 TCGA−CA−5254−01 TCGA−AA−3955−01 TCGA−AG−A02G−01 TCGA−A6−2676−01 TCGA−AA−A02W−01 TCGA−AA−3821−01 TCGA−A6−3810−01 TCGA−AA−3854−01 TCGA−AA−A01Z−01 TCGA−AA−3972−01 TCGA−DY−A1DF−01 TCGA−AD−6889−01 TCGA−AA−3516−01 TCGA−CM−5348−01 TCGA−DM−A28K−01 TCGA−AA−3672−01 TCGA−DM−A1D4−01 TCGA−AD−6901−01 TCGA−AA−A022−01 TCGA−CM−5341−01 TCGA−AA−A01P−01 TCGA−A6−2671−01 TCGA−AA−3543−01 TCGA−EI−6506−01 TCGA−AA−3520−01 TCGA−AA−3555−01 TCGA−AG−4001−01 TCGA−AA−3845−01 TCGA−AA−3710−01 TCGA−AY−6196−01 TCGA−D5−6533−01 TCGA−F4−6704−01 TCGA−CM−5868−01 TCGA−AZ−6607−01 TCGA−AA−A02K−01 TCGA−A6−6653−01 TCGA−AA−A01R−01 TCGA−DM−A282−01 TCGA−AG−A00Y−01 TCGA−AG−3883−01 TCGA−AG−3600−01 TCGA−AA−A00E−01 TCGA−AA−3525−01 TCGA−A6−6781−01 TCGA−G4−6309−01 TCGA−AG−3892−01 TCGA−G4−6626−01 TCGA−EI−6508−01 TCGA−D5−6922−01 TCGA−AA−3833−01 TCGA−AH−6549−01 TCGA−AG−A025−01 TCGA−AG−3726−01 TCGA−AA−3664−01 TCGA−AA−3552−01 TCGA−AZ−6600−01 TCGA−AG−3902−01 TCGA−AA−3994−01 TCGA−A6−6138−01 TCGA−F5−6464−01 TCGA−D5−6539−01 TCGA−CM−6675−01 TCGA−AG−3898−01 TCGA−AG−3732−01 TCGA−AD−6888−01 TCGA−AA−3869−01 TCGA−AA−3502−01 TCGA−AG−A002−01 TCGA−AA−3984−01 TCGA−D5−6928−01 TCGA−AA−A01Q−01 TCGA−AA−3966−01 TCGA−CM−6170−01 TCGA−CK−5913−01 TCGA−DM−A1DA−01 TCGA−CM−6167−01 TCGA−AG−3599−01 TCGA−AF−4110−01 TCGA−AD−6895−01 TCGA−A6−2672−01 TCGA−F4−6703−01 TCGA−EI−6510−01 TCGA−D5−6932−01 TCGA−CM−6163−01 TCGA−AY−4071−01 TCGA−AG−3581−01 TCGA−AA−3982−01 TCGA−AA−3875−01 TCGA−AA−3861−01 TCGA−AA−3814−01 TCGA−A6−6137−01 TCGA−AA−A010−01 TCGA−CA−6717−01 TCGA−AA−A00N−01 TCGA−AZ−4315−01 TCGA−AZ−6598−01 TCGA−AA−3977−01 TCGA−AA−3510−01 TCGA−AA−3713−01 TCGA−A6−6780−01 TCGA−D5−6540−01 TCGA−CA−6718−01 TCGA−AZ−6601−01 TCGA−AU−6004−01 TCGA−AA−3947−01 TCGA−A6−5661−01 TCGA−G4−6588−01 TCGA−D5−6927−01 TCGA−D5−6532−01 TCGA−CM−6162−01 TCGA−CK−6746−01 TCGA−AY−6197−01 TCGA−AD−6964−01 TCGA−AA−3950−01 TCGA−AA−3815−01 TCGA−AA−3663−01 TCGA−A6−5665−01 TCGA−G4−6315−01 TCGA−G4−6303−01 TCGA−F4−6570−01 TCGA−DM−A1DB−01 TCGA−CM−6171−01 TCGA−CM−5861−01 TCGA−CM−4752−01 TCGA−CM−4746−01 TCGA−CK−5916−01 TCGA−AZ−6608−01 TCGA−AY−5543−01 TCGA−AF−6136−01 TCGA−AD−5900−01 TCGA−AA−3864−01 TCGA−AA−3660−01 TCGA−A6−6141−01 TCGA−A6−4105−01 TCGA−G4−6628−01 TCGA−G4−6625−01 TCGA−G4−6586−01 TCGA−G4−6307−01 TCGA−G4−6304−01 TCGA−G4−6293−01 TCGA−F4−6856−01 TCGA−F4−6807−01 TCGA−F4−6459−01 TCGA−EI−6507−01 TCGA−DY−A1DG−01 TCGA−DM−A0XF−01 TCGA−DM−A0XD−01 TCGA−D5−6541−01 TCGA−CM−6674−01 TCGA−CM−6169−01 TCGA−CM−6161−01 TCGA−CM−5864−01 TCGA−CM−5862−01 TCGA−CM−5860−01 TCGA−CM−4743−01 TCGA−CK−4950−01 TCGA−AZ−6599−01 TCGA−AZ−4616−01 TCGA−AU−3779−01 TCGA−AH−6644−01 TCGA−AH−6544−01 TCGA−AG−A02N−01 TCGA−AA−3662−01 TCGA−AA−3511−01 TCGA−A6−5666−01 TCGA−A6−5662−01 TCGA−A6−5660−01 TCGA−A6−5657−01 TCGA−A6−3809−01 TCGA−G4−6323−01 TCGA−G4−6299−01 TCGA−F5−6571−01 TCGA−F4−6855−01 TCGA−F4−6808−01 TCGA−F4−6569−01 TCGA−F4−6460−01 TCGA−EF−5830−01 TCGA−DY−A0XA−01 TCGA−DT−5265−01 TCGA−DM−A28G−01 TCGA−DM−A285−01 TCGA−DM−A1D9−01 TCGA−DM−A1D8−01 TCGA−DC−6683−01 TCGA−DC−5869−01 TCGA−D5−6931−01 TCGA−D5−6929−01 TCGA−D5−6920−01 TCGA−D5−6898−01 TCGA−D5−6538−01 TCGA−D5−5541−01 TCGA−D5−5540−01 TCGA−D5−5538−01 TCGA−CM−6680−01 TCGA−CM−6678−01 TCGA−CM−6172−01 TCGA−CM−6164−01 TCGA−CM−5349−01 TCGA−CK−5914−01 TCGA−CK−4952−01 TCGA−CK−4948−01 TCGA−CK−4947−01 TCGA−CI−6624−01 TCGA−CA−6719−01 TCGA−AZ−6606−01 TCGA−AZ−5407−01 TCGA−AZ−5403−01 TCGA−AH−6643−01 TCGA−AG−3878−01 TCGA−AF−6672−01 TCGA−AF−2693−01 TCGA−AD−6963−01 TCGA−AD−6899−01 TCGA−AA−3877−01 TCGA−AA−3850−01 TCGA−AA−3818−01 TCGA−AA−3712−01 TCGA−AA−3697−01 TCGA−AA−3696−01 TCGA−AA−3492−01 TCGA−AA−3489−01 TCGA−A6−6649−01 TCGA−A6−5656−01 TCGA−G5−6235−01 TCGA−G4−6317−01 TCGA−G4−6310−01 TCGA−F5−6813−01 TCGA−F5−6811−01 TCGA−F4−6854−01 TCGA−F4−6809−01 TCGA−F4−6805−01 TCGA−DY−A1DC−01 TCGA−DM−A28H−01 TCGA−DM−A28C−01 TCGA−DM−A1HA−01 TCGA−DM−A1D7−01 TCGA−DM−A0X9−01 TCGA−DC−6682−01 TCGA−DC−6160−01 TCGA−DC−6158−01 TCGA−DC−6157−01 TCGA−D5−7000−01 TCGA−D5−6926−01 TCGA−D5−6923−01 TCGA−D5−6537−01 TCGA−D5−6536−01 TCGA−D5−6534−01 TCGA−D5−6529−01 TCGA−D5−5539−01 TCGA−CM−6676−01 TCGA−CM−6168−01 TCGA−CM−6166−01 TCGA−CM−5344−01 TCGA−CM−4747−01 TCGA−CL−5918−01 TCGA−CL−5917−01 TCGA−CK−6747−01 TCGA−CK−5912−01 TCGA−CI−6622−01 TCGA−CI−6619−01 TCGA−AZ−4682−01 TCGA−AY−6386−01 TCGA−AG−A020−01 TCGA−AG−A00H−01 TCGA−AG−4015−01 TCGA−AG−3901−01 TCGA−AG−3887−01 TCGA−AG−3742−01 TCGA−AG−3731−01 TCGA−AF−2687−01 TCGA−AD−6965−01 TCGA−AD−6890−01 TCGA−AD−6548−01 TCGA−AA−A03J−01 TCGA−AA−A03F−01 TCGA−AA−A02Y−01 TCGA−AA−A02O−01 TCGA−AA−A01V−01 TCGA−AA−A01K−01 TCGA−AA−A01I−01 TCGA−AA−3956−01 TCGA−AA−3939−01 TCGA−AA−3866−01 TCGA−AA−3852−01 TCGA−AA−3848−01 TCGA−AA−3837−01 TCGA−AA−3812−01 TCGA−AA−3715−01 TCGA−AA−3673−01 TCGA−AA−3655−01 TCGA−AA−3496−01 TCGA−A6−6782−01 TCGA−A6−6654−01 TCGA−A6−6652−01 TCGA−A6−5659−01 TCGA−A6−3808−01

TCGA−AA−3514−01 TCGA−AG−3601−01 TCGA−AA−3562−01 TCGA−AG−4007−01 TCGA−AZ−4323−01 TCGA−AA−3543−01 TCGA−AA−3554−01 TCGA−CK−5913−01 TCGA−AA−3811−01 TCGA−AG−A02G−01 TCGA−A6−2676−01 TCGA−AG−3898−01 TCGA−AA−3869−01 TCGA−AA−A00J−01 TCGA−AA−3518−01 TCGA−AZ−4681−01 TCGA−A6−2672−01 TCGA−DY−A1DD−01 TCGA−DM−A28F−01 TCGA−CK−5915−01 TCGA−AG−A036−01 TCGA−AH−6549−01 TCGA−AA−3833−01 TCGA−AA−3664−01 TCGA−AA−3552−01 TCGA−AA−A01Q−01 TCGA−AG−3883−01 TCGA−AA−A00E−01 TCGA−AA−3525−01 TCGA−AD−6888−01 TCGA−AA−3845−01 TCGA−AG−3584−01 TCGA−AA−A00D−01 TCGA−A6−6781−01 TCGA−AA−3949−01 TCGA−AA−3710−01 TCGA−AA−3980−01 TCGA−AA−3867−01 TCGA−AA−3821−01 TCGA−A6−6651−01 TCGA−D5−6928−01 TCGA−F5−6464−01 TCGA−AG−3600−01 TCGA−AA−A00R−01 TCGA−CM−5348−01 TCGA−AA−A022−01 TCGA−AA−3672−01 TCGA−AA−3519−01 TCGA−AA−3516−01 TCGA−CM−6675−01 TCGA−D5−6922−01 TCGA−CM−6167−01 TCGA−AG−3732−01 TCGA−G4−6321−01 TCGA−AZ−6603−01 TCGA−AA−3968−01 TCGA−A6−6142−01 TCGA−AG−A002−01 TCGA−AA−3984−01 TCGA−G4−6309−01 TCGA−EI−6508−01 TCGA−D5−6533−01 TCGA−CM−6170−01 TCGA−AA−3966−01 TCGA−F4−6704−01 TCGA−CM−5868−01 TCGA−AY−6196−01 TCGA−AA−A02K−01 TCGA−DC−5337−01 TCGA−DM−A1DA−01 TCGA−AA−A02F−01 TCGA−AA−3976−01 TCGA−AA−3819−01 TCGA−AA−3666−01 TCGA−AA−3549−01 TCGA−F5−6465−01 TCGA−CA−5797−01 TCGA−AG−A01L−01 TCGA−AG−3894−01 TCGA−AF−3913−01 TCGA−AA−A024−01 TCGA−AA−A00F−01 TCGA−AA−3973−01 TCGA−AA−3972−01 TCGA−A6−2678−01 TCGA−AA−A010−01 TCGA−CA−6717−01 TCGA−G4−6307−01 TCGA−CM−6171−01 TCGA−F4−6570−01 TCGA−AA−3950−01 TCGA−AA−3815−01 TCGA−G4−6304−01 TCGA−D5−6929−01 TCGA−CM−6162−01 TCGA−CM−6161−01 TCGA−CM−5349−01 TCGA−CK−6746−01 TCGA−AY−6197−01 TCGA−AU−6004−01 TCGA−AU−3779−01 TCGA−AD−5900−01 TCGA−AA−3947−01 TCGA−AA−3662−01 TCGA−AA−3510−01 TCGA−G4−6588−01 TCGA−G4−6310−01 TCGA−CM−5864−01 TCGA−CM−5860−01 TCGA−CM−4752−01 TCGA−AF−6136−01 TCGA−AA−3877−01 TCGA−AA−3492−01 TCGA−A6−6780−01 TCGA−G4−6628−01 TCGA−G4−6315−01 TCGA−G4−6303−01 TCGA−G4−6299−01 TCGA−DC−6682−01 TCGA−D5−6540−01 TCGA−D5−6534−01 TCGA−D5−5541−01 TCGA−CM−6172−01 TCGA−CM−5344−01 TCGA−CL−5918−01 TCGA−CK−5916−01 TCGA−CK−5914−01 TCGA−AH−6643−01 TCGA−AF−2693−01 TCGA−AD−6963−01 TCGA−AA−A01V−01 TCGA−AA−3956−01 TCGA−AA−3712−01 TCGA−AA−3697−01 TCGA−G4−6293−01 TCGA−F5−6811−01 TCGA−F4−6809−01 TCGA−F4−6569−01 TCGA−F4−6460−01 TCGA−DY−A1DG−01 TCGA−DY−A1DC−01 TCGA−DY−A0XA−01 TCGA−DT−5265−01 TCGA−DM−A0XF−01 TCGA−DC−5869−01 TCGA−D5−6926−01 TCGA−CM−6680−01 TCGA−CM−6676−01 TCGA−CM−6169−01 TCGA−CM−5861−01 TCGA−CK−6747−01 TCGA−CK−5912−01 TCGA−CK−4952−01 TCGA−CA−6719−01 TCGA−AZ−5403−01 TCGA−AG−4015−01 TCGA−AD−6899−01 TCGA−AD−6890−01 TCGA−AA−3850−01 TCGA−A6−5660−01 TCGA−A6−5656−01 TCGA−G4−6317−01 TCGA−F5−6813−01 TCGA−F4−6808−01 TCGA−F4−6459−01 TCGA−DM−A28C−01 TCGA−DC−6158−01 TCGA−DC−6157−01 TCGA−D5−6923−01 TCGA−D5−6920−01 TCGA−D5−6898−01 TCGA−CI−6624−01 TCGA−CI−6619−01 TCGA−AZ−4682−01 TCGA−AF−2687−01 TCGA−AA−3866−01 TCGA−AA−3812−01 TCGA−AA−3496−01 TCGA−AA−3489−01 TCGA−A6−6652−01 TCGA−A6−6649−01 TCGA−A6−3809−01 TCGA−AZ−4315−01 TCGA−AZ−6598−01 TCGA−AG−3892−01 TCGA−A6−5661−01 TCGA−D5−6532−01 TCGA−AA−A00N−01 TCGA−AA−3713−01 TCGA−G4−6586−01 TCGA−CM−4746−01 TCGA−CA−6718−01 TCGA−AD−6889−01 TCGA−AA−3977−01 TCGA−AA−3663−01 TCGA−A6−5665−01 TCGA−D5−6927−01 TCGA−D5−6536−01 TCGA−AZ−6601−01 TCGA−AY−5543−01 TCGA−AA−3864−01 TCGA−A6−6141−01 TCGA−A6−5666−01 TCGA−A6−5657−01 TCGA−F4−6856−01 TCGA−EI−6507−01 TCGA−CM−5862−01 TCGA−CM−4743−01 TCGA−CK−4947−01 TCGA−AZ−6599−01 TCGA−AA−A01R−01 TCGA−AA−3715−01 TCGA−AA−3660−01 TCGA−AA−3555−01 TCGA−G4−6626−01 TCGA−G4−6625−01 TCGA−F4−6807−01 TCGA−EF−5830−01 TCGA−DM−A1HA−01 TCGA−DM−A1DB−01 TCGA−DM−A1D9−01 TCGA−DM−A0XD−01 TCGA−DM−A0X9−01 TCGA−D5−6931−01 TCGA−D5−6541−01 TCGA−D5−6539−01 TCGA−D5−6538−01 TCGA−D5−5538−01 TCGA−CM−6674−01 TCGA−CM−6164−01 TCGA−CK−4950−01 TCGA−CK−4948−01 TCGA−AZ−6608−01 TCGA−AY−6386−01 TCGA−AH−6644−01 TCGA−AG−A02N−01 TCGA−AD−6964−01 TCGA−A6−4105−01 TCGA−G4−6323−01 TCGA−G4−6306−01 TCGA−F4−6855−01 TCGA−F4−6805−01 TCGA−F4−6703−01 TCGA−DM−A28H−01 TCGA−DM−A285−01 TCGA−DM−A282−01 TCGA−DM−A1D8−01 TCGA−DC−6683−01 TCGA−D5−6537−01 TCGA−D5−6535−01 TCGA−CM−6168−01 TCGA−CM−6166−01 TCGA−CI−6622−01 TCGA−CA−6716−01 TCGA−AZ−6606−01 TCGA−AZ−5407−01 TCGA−AZ−4616−01 TCGA−AH−6544−01 TCGA−AG−3726−01 TCGA−AF−6672−01 TCGA−AD−6895−01 TCGA−AA−A00K−01 TCGA−AA−3854−01 TCGA−AA−3848−01 TCGA−AA−3696−01 TCGA−AA−3655−01 TCGA−AA−3511−01 TCGA−A6−6138−01 TCGA−A6−5662−01 TCGA−G5−6235−01 TCGA−F5−6571−01 TCGA−F4−6854−01 TCGA−F4−6806−01 TCGA−EI−6510−01 TCGA−EI−6506−01 TCGA−DY−A1H8−01 TCGA−DY−A1DF−01 TCGA−DM−A28K−01 TCGA−DM−A28G−01 TCGA−DM−A1D7−01 TCGA−DM−A1D6−01 TCGA−DM−A1D4−01 TCGA−DC−6160−01 TCGA−D5−7000−01 TCGA−D5−6932−01 TCGA−D5−6529−01 TCGA−D5−5540−01 TCGA−D5−5539−01 TCGA−D5−5537−01 TCGA−CM−6678−01 TCGA−CM−5863−01 TCGA−CM−4747−01 TCGA−CL−5917−01 TCGA−AZ−6607−01 TCGA−AZ−6605−01 TCGA−AZ−6600−01 TCGA−AG−A032−01 TCGA−AG−A025−01 TCGA−AG−A020−01 TCGA−AG−A00Y−01 TCGA−AG−A00H−01 TCGA−AG−4005−01 TCGA−AG−3909−01 TCGA−AG−3902−01 TCGA−AG−3901−01 TCGA−AG−3887−01 TCGA−AG−3878−01 TCGA−AG−3742−01 TCGA−AG−3731−01 TCGA−AG−3599−01 TCGA−AF−4110−01 TCGA−AF−2691−01 TCGA−AD−6965−01 TCGA−AD−6548−01 TCGA−AA−A03J−01 TCGA−AA−A03F−01 TCGA−AA−A02Y−01 TCGA−AA−A02O−01 TCGA−AA−A01K−01 TCGA−AA−A01I−01 TCGA−AA−A00A−01 TCGA−AA−3994−01 TCGA−AA−3979−01 TCGA−AA−3939−01 TCGA−AA−3870−01 TCGA−AA−3852−01 TCGA−AA−3837−01 TCGA−AA−3818−01 TCGA−AA−3695−01 TCGA−AA−3673−01 TCGA−AA−3558−01 TCGA−AA−3502−01 TCGA−A6−6782−01 TCGA−A6−6654−01 TCGA−A6−6653−01 TCGA−A6−5659−01 TCGA−A6−3808−01 TCGA−A6−2683−01 TCGA−F5−6812−01 TCGA−F5−6702−01 TCGA−DM−A1D0−01 TCGA−DC−6155−01 TCGA−D5−6930−01 TCGA−CM−6163−01 TCGA−CM−4744−01 TCGA−CI−6620−01 TCGA−CA−5796−01 TCGA−AG−A02X−01 TCGA−AG−A01W−01 TCGA−AG−A015−01 TCGA−AG−A014−01 TCGA−AG−A00C−01 TCGA−AG−A008−01 TCGA−AG−4008−01 TCGA−AG−3999−01 TCGA−AG−3896−01 TCGA−AG−3885−01 TCGA−AG−3727−01 TCGA−AG−3611−01 TCGA−AG−3605−01 TCGA−AG−3602−01 TCGA−AG−3594−01 TCGA−AG−3586−01 TCGA−AG−3583−01 TCGA−AG−3581−01 TCGA−AG−3580−01 TCGA−AG−3575−01 TCGA−AF−6655−01 TCGA−AF−5654−01 TCGA−AF−2692−01 TCGA−AF−2689−01 TCGA−AD−6901−01 TCGA−AA−A02W−01 TCGA−AA−A029−01 TCGA−AA−A01Z−01 TCGA−AA−A01X−01 TCGA−AA−A01G−01 TCGA−AA−A01F−01 TCGA−AA−A00Q−01 TCGA−AA−3986−01 TCGA−AA−3975−01 TCGA−AA−3941−01 TCGA−AA−3930−01 TCGA−AA−3851−01 TCGA−AA−3844−01 TCGA−AA−3842−01 TCGA−AA−3814−01 TCGA−AA−3681−01 TCGA−AA−3680−01 TCGA−AA−3561−01 TCGA−AA−3560−01 TCGA−AA−3556−01 TCGA−AA−3548−01 TCGA−AA−3532−01 TCGA−AA−3530−01 TCGA−AA−3522−01 TCGA−AA−3521−01 TCGA−AA−3520−01 TCGA−A6−5664−01

FGF Signaling Pathway FDR = 1.9e−12%, FDR nod = 0.00054% FCERI Mediated MAPK Activation FDR = 1.9e−12%, FDR nod = 0.049%

TCGA−AG−A032−01 TCGA−AG−3601−01 TCGA−AA−3949−01 TCGA−CK−5915−01 TCGA−AZ−6607−01 TCGA−G4−6626−01 TCGA−AA−3870−01 TCGA−D5−6928−01 TCGA−AA−3821−01 TCGA−AA−3516−01 TCGA−D5−5537−01 TCGA−AZ−6605−01 TCGA−AA−3811−01 TCGA−D5−6533−01 TCGA−CK−5913−01 TCGA−AA−3979−01 TCGA−F4−6703−01 TCGA−DC−6155−01 TCGA−CM−6167−01 TCGA−AD−6895−01 TCGA−AA−3984−01 TCGA−G4−6309−01 TCGA−F4−6806−01 TCGA−DM−A28K−01 TCGA−CM−4744−01 TCGA−AZ−4681−01 TCGA−AA−A01R−01 TCGA−AA−A01Q−01 TCGA−D5−6930−01 TCGA−CI−6621−01 TCGA−AA−3972−01 TCGA−A6−6781−01 TCGA−A6−6653−01 TCGA−AG−A002−01 TCGA−AD−6889−01 TCGA−DM−A28F−01 TCGA−AA−3710−01 TCGA−EI−6506−01 TCGA−DM−A1D6−01 TCGA−D5−6539−01 TCGA−D5−6535−01 TCGA−CM−5348−01 TCGA−AZ−6600−01 TCGA−AY−6196−01 TCGA−AG−3892−01 TCGA−AF−6655−01 TCGA−AD−6901−01 TCGA−A6−6142−01 TCGA−A6−6138−01 TCGA−AZ−4315−01 TCGA−AA−A010−01 TCGA−CA−6717−01 TCGA−F5−6811−01 TCGA−D5−6540−01 TCGA−AD−6964−01 TCGA−G4−6586−01 TCGA−F4−6856−01 TCGA−DY−A0XA−01 TCGA−D5−6931−01 TCGA−D5−6898−01 TCGA−CM−6171−01 TCGA−CM−6166−01 TCGA−CM−6162−01 TCGA−CM−4743−01 TCGA−CK−4952−01 TCGA−CK−4950−01 TCGA−AZ−6601−01 TCGA−AZ−6599−01 TCGA−AZ−6598−01 TCGA−AA−A00N−01 TCGA−AA−3712−01 TCGA−AA−3663−01 TCGA−AA−3510−01 TCGA−A6−6141−01 TCGA−A6−5665−01 TCGA−A6−5662−01 TCGA−G5−6235−01 TCGA−G4−6628−01 TCGA−G4−6625−01 TCGA−G4−6588−01 TCGA−G4−6323−01 TCGA−G4−6317−01 TCGA−G4−6315−01 TCGA−G4−6310−01 TCGA−G4−6304−01 TCGA−G4−6303−01 TCGA−G4−6299−01 TCGA−G4−6293−01 TCGA−F4−6570−01 TCGA−F4−6459−01 TCGA−DM−A28G−01 TCGA−DM−A1DB−01 TCGA−DM−A1D7−01 TCGA−DM−A0XF−01 TCGA−DC−6682−01 TCGA−D5−6541−01 TCGA−D5−6537−01 TCGA−D5−6536−01 TCGA−D5−6534−01 TCGA−D5−6529−01 TCGA−CM−6680−01 TCGA−CM−6168−01 TCGA−CM−5864−01 TCGA−CM−5862−01 TCGA−CM−5861−01 TCGA−CM−5860−01 TCGA−CM−4752−01 TCGA−CM−4746−01 TCGA−CK−6746−01 TCGA−CK−4948−01 TCGA−CI−6622−01 TCGA−CA−6719−01 TCGA−AZ−5403−01 TCGA−AY−6386−01 TCGA−AY−6197−01 TCGA−AF−6136−01 TCGA−AF−2693−01 TCGA−AD−6963−01 TCGA−AD−5900−01 TCGA−AA−3977−01 TCGA−AA−3947−01 TCGA−AA−3939−01 TCGA−AA−3864−01 TCGA−AA−3715−01 TCGA−AA−3713−01 TCGA−AA−3660−01 TCGA−AA−3492−01 TCGA−AA−3489−01 TCGA−A6−6780−01 TCGA−A6−5666−01 TCGA−A6−5661−01 TCGA−A6−5660−01 TCGA−G4−6307−01 TCGA−F5−6813−01 TCGA−F5−6571−01 TCGA−F4−6855−01 TCGA−F4−6854−01 TCGA−F4−6809−01 TCGA−F4−6808−01 TCGA−F4−6807−01 TCGA−F4−6805−01 TCGA−F4−6569−01 TCGA−F4−6460−01 TCGA−EI−6507−01 TCGA−EF−5830−01 TCGA−DY−A1DG−01 TCGA−DY−A1DC−01 TCGA−DT−5265−01 TCGA−DM−A28H−01 TCGA−DM−A28C−01 TCGA−DM−A285−01 TCGA−DM−A1HA−01 TCGA−DM−A1D9−01 TCGA−DM−A1D8−01 TCGA−DM−A0XD−01 TCGA−DM−A0X9−01 TCGA−DC−6683−01 TCGA−DC−6160−01 TCGA−DC−6158−01 TCGA−DC−6157−01 TCGA−DC−5869−01 TCGA−D5−7000−01 TCGA−D5−6929−01 TCGA−D5−6927−01 TCGA−D5−6926−01 TCGA−D5−6923−01 TCGA−D5−6920−01 TCGA−D5−6538−01 TCGA−D5−6532−01 TCGA−D5−5541−01 TCGA−D5−5540−01 TCGA−D5−5539−01 TCGA−D5−5538−01 TCGA−CM−6678−01 TCGA−CM−6676−01 TCGA−CM−6674−01 TCGA−CM−6172−01 TCGA−CM−6169−01 TCGA−CM−6164−01 TCGA−CM−6161−01 TCGA−CM−5349−01 TCGA−CM−5344−01 TCGA−CM−4747−01 TCGA−CL−5918−01 TCGA−CL−5917−01 TCGA−CK−6747−01 TCGA−CK−5916−01 TCGA−CK−5914−01 TCGA−CK−5912−01 TCGA−CK−4947−01 TCGA−CI−6624−01 TCGA−CI−6619−01 TCGA−CA−6718−01 TCGA−AZ−6608−01 TCGA−AZ−6606−01 TCGA−AZ−5407−01 TCGA−AZ−4682−01 TCGA−AZ−4616−01 TCGA−AY−5543−01 TCGA−AU−6004−01 TCGA−AU−3779−01 TCGA−AH−6644−01 TCGA−AH−6643−01 TCGA−AH−6544−01 TCGA−AG−A02N−01 TCGA−AG−A020−01 TCGA−AG−A00H−01 TCGA−AG−4015−01 TCGA−AG−3901−01 TCGA−AG−3887−01 TCGA−AG−3878−01 TCGA−AG−3742−01 TCGA−AG−3731−01 TCGA−AF−6672−01 TCGA−AF−2687−01 TCGA−AD−6965−01 TCGA−AD−6899−01 TCGA−AD−6890−01 TCGA−AD−6548−01 TCGA−AA−A03J−01 TCGA−AA−A03F−01 TCGA−AA−A02Y−01 TCGA−AA−A02O−01 TCGA−AA−A01V−01 TCGA−AA−A01K−01 TCGA−AA−A01I−01 TCGA−AA−3956−01 TCGA−AA−3950−01 TCGA−AA−3877−01 TCGA−AA−3866−01 TCGA−AA−3852−01 TCGA−AA−3850−01 TCGA−AA−3848−01 TCGA−AA−3837−01 TCGA−AA−3818−01 TCGA−AA−3815−01 TCGA−AA−3812−01 TCGA−AA−3697−01 TCGA−AA−3696−01 TCGA−AA−3673−01 TCGA−AA−3662−01 TCGA−AA−3655−01 TCGA−AA−3511−01 TCGA−AA−3496−01 TCGA−A6−6782−01 TCGA−A6−6654−01 TCGA−A6−6652−01 TCGA−A6−6649−01 TCGA−A6−5659−01 TCGA−A6−5657−01 TCGA−A6−5656−01 TCGA−A6−4105−01 TCGA−A6−3809−01 TCGA−A6−3808−01

TCGA−AA−3534−01 TCGA−D5−6922−01 TCGA−D5−6929−01 TCGA−D5−6928−01 TCGA−CM−6161−01 TCGA−AF−2687−01 TCGA−AG−3601−01 TCGA−AA−3516−01 TCGA−G4−6293−01 TCGA−AA−3815−01 TCGA−AD−6963−01 TCGA−AA−A022−01 TCGA−G4−6309−01 TCGA−AD−6890−01 TCGA−AY−6197−01 TCGA−AA−3712−01 TCGA−AA−3543−01 TCGA−AA−3510−01 TCGA−AA−A01P−01 TCGA−AA−3855−01 TCGA−AA−3812−01 TCGA−AZ−5403−01 TCGA−AG−3584−01 TCGA−AD−6888−01 TCGA−AA−A00D−01 TCGA−A6−6781−01 TCGA−F5−6811−01 TCGA−F4−6459−01 TCGA−D5−6898−01 TCGA−CI−6621−01 TCGA−D5−6533−01 TCGA−CM−5861−01 TCGA−CK−5913−01 TCGA−AD−5900−01 TCGA−AA−3811−01 TCGA−A6−6780−01 TCGA−F4−6570−01 TCGA−AA−A01Q−01 TCGA−CL−5918−01 TCGA−CM−5349−01 TCGA−AZ−4323−01 TCGA−AU−3779−01 TCGA−AA−3877−01 TCGA−AA−3947−01 TCGA−AA−3950−01 TCGA−G4−6588−01 TCGA−G4−6303−01 TCGA−CM−5348−01 TCGA−AA−A02K−01 TCGA−AA−3821−01 TCGA−AA−3531−01 TCGA−AA−3525−01 TCGA−G4−6628−01 TCGA−AA−3492−01 TCGA−CM−6172−01 TCGA−CK−6746−01 TCGA−CK−4952−01 TCGA−AA−3845−01 TCGA−AY−6196−01 TCGA−AD−6899−01 TCGA−AA−3966−01 TCGA−AA−3952−01 TCGA−AA−3861−01 TCGA−AG−A002−01 TCGA−AA−A010−01 TCGA−CA−6717−01 TCGA−CM−6171−01 TCGA−AA−3984−01 TCGA−AA−3672−01 TCGA−D5−6540−01 TCGA−CM−5868−01 TCGA−AA−3949−01 TCGA−A6−2672−01 TCGA−G4−6321−01 TCGA−CM−6677−01 TCGA−AZ−6603−01 TCGA−AH−6547−01 TCGA−AG−A01Y−01 TCGA−AA−3867−01 TCGA−DM−A1DA−01 TCGA−G4−6304−01 TCGA−CM−6162−01 TCGA−AA−3662−01 TCGA−DC−6682−01 TCGA−DC−5337−01 TCGA−AF−6136−01 TCGA−AF−3913−01 TCGA−AA−A02F−01 TCGA−AA−3972−01 TCGA−G4−6315−01 TCGA−G4−6307−01 TCGA−F5−6465−01 TCGA−CM−6680−01 TCGA−CM−5864−01 TCGA−CA−5797−01 TCGA−AG−A01L−01 TCGA−AG−3894−01 TCGA−AA−A024−01 TCGA−AA−A01V−01 TCGA−AA−A00F−01 TCGA−AA−3976−01 TCGA−AA−3973−01 TCGA−AA−3850−01 TCGA−AA−3819−01 TCGA−AA−3666−01 TCGA−AA−3549−01 TCGA−A6−2678−01 TCGA−G4−6586−01 TCGA−AZ−4315−01 TCGA−AG−3892−01 TCGA−CK−4948−01 TCGA−CA−6718−01 TCGA−AA−A01R−01 TCGA−AA−A00N−01 TCGA−D5−6539−01 TCGA−CM−4743−01 TCGA−AZ−6598−01 TCGA−AG−A02N−01 TCGA−A6−5661−01 TCGA−G4−6626−01 TCGA−CK−4947−01 TCGA−AA−3864−01 TCGA−AA−3713−01 TCGA−G4−6625−01 TCGA−F4−6703−01 TCGA−DM−A0X9−01 TCGA−D5−6930−01 TCGA−D5−6536−01 TCGA−D5−6535−01 TCGA−D5−5538−01 TCGA−AZ−6601−01 TCGA−AY−6386−01 TCGA−AD−6964−01 TCGA−AD−6889−01 TCGA−AA−3663−01 TCGA−AA−3555−01 TCGA−A6−6141−01 TCGA−A6−5666−01 TCGA−A6−5665−01 TCGA−G4−6306−01 TCGA−F5−6812−01 TCGA−F4−6856−01 TCGA−F4−6805−01 TCGA−EI−6510−01 TCGA−EI−6507−01 TCGA−DY−A1H8−01 TCGA−DM−A28H−01 TCGA−DM−A1DB−01 TCGA−DM−A1D9−01 TCGA−DM−A1D6−01 TCGA−D5−6932−01 TCGA−D5−6927−01 TCGA−D5−6541−01 TCGA−D5−6538−01 TCGA−D5−6537−01 TCGA−D5−5540−01 TCGA−D5−5539−01 TCGA−CM−6168−01 TCGA−CM−6166−01 TCGA−CM−6164−01 TCGA−CM−5862−01 TCGA−CM−4746−01 TCGA−CK−4950−01 TCGA−CI−6622−01 TCGA−CA−6716−01 TCGA−AH−6644−01 TCGA−AG−A032−01 TCGA−AG−A020−01 TCGA−AG−A00Y−01 TCGA−AG−4005−01 TCGA−AG−3727−01 TCGA−AF−2691−01 TCGA−AD−6901−01 TCGA−AD−6548−01 TCGA−AA−A02O−01 TCGA−AA−A01G−01 TCGA−AA−3986−01 TCGA−AA−3979−01 TCGA−AA−3977−01 TCGA−AA−3870−01 TCGA−AA−3814−01 TCGA−AA−3715−01 TCGA−AA−3558−01 TCGA−A6−6653−01 TCGA−A6−6138−01 TCGA−A6−5662−01 TCGA−A6−5657−01 TCGA−A6−2683−01 TCGA−G5−6235−01 TCGA−G4−6323−01 TCGA−F5−6702−01 TCGA−F5−6571−01 TCGA−F4−6855−01 TCGA−F4−6854−01 TCGA−F4−6807−01 TCGA−F4−6806−01 TCGA−EI−6506−01 TCGA−EF−5830−01 TCGA−DY−A1DF−01 TCGA−DM−A28K−01 TCGA−DM−A28G−01 TCGA−DM−A285−01 TCGA−DM−A282−01 TCGA−DM−A1HA−01 TCGA−DM−A1D8−01 TCGA−DM−A1D7−01 TCGA−DM−A1D4−01 TCGA−DM−A1D0−01 TCGA−DM−A0XD−01 TCGA−DC−6683−01 TCGA−DC−6160−01 TCGA−DC−6155−01 TCGA−D5−7000−01 TCGA−D5−6931−01 TCGA−D5−6532−01 TCGA−D5−6529−01 TCGA−D5−5537−01 TCGA−CM−6678−01 TCGA−CM−6674−01 TCGA−CM−6163−01 TCGA−CM−5863−01 TCGA−CM−4747−01 TCGA−CM−4744−01 TCGA−CL−5917−01 TCGA−CI−6620−01 TCGA−CA−5796−01 TCGA−AZ−6608−01 TCGA−AZ−6607−01 TCGA−AZ−6606−01 TCGA−AZ−6605−01 TCGA−AZ−6600−01 TCGA−AZ−6599−01 TCGA−AZ−5407−01 TCGA−AZ−4616−01 TCGA−AY−5543−01 TCGA−AH−6544−01 TCGA−AG−A02X−01 TCGA−AG−A025−01 TCGA−AG−A01W−01 TCGA−AG−A015−01 TCGA−AG−A014−01 TCGA−AG−A00H−01 TCGA−AG−A00C−01 TCGA−AG−A008−01 TCGA−AG−4008−01 TCGA−AG−3999−01 TCGA−AG−3909−01 TCGA−AG−3902−01 TCGA−AG−3901−01 TCGA−AG−3896−01 TCGA−AG−3887−01 TCGA−AG−3885−01 TCGA−AG−3878−01 TCGA−AG−3742−01 TCGA−AG−3731−01 TCGA−AG−3726−01 TCGA−AG−3611−01 TCGA−AG−3605−01 TCGA−AG−3602−01 TCGA−AG−3599−01 TCGA−AG−3594−01 TCGA−AG−3586−01 TCGA−AG−3583−01 TCGA−AG−3581−01 TCGA−AG−3580−01 TCGA−AG−3575−01 TCGA−AF−6672−01 TCGA−AF−6655−01 TCGA−AF−5654−01 TCGA−AF−4110−01 TCGA−AF−2692−01 TCGA−AF−2689−01 TCGA−AD−6965−01 TCGA−AD−6895−01 TCGA−AA−A03J−01 TCGA−AA−A03F−01 TCGA−AA−A02Y−01 TCGA−AA−A02W−01 TCGA−AA−A029−01 TCGA−AA−A01Z−01 TCGA−AA−A01X−01 TCGA−AA−A01K−01 TCGA−AA−A01I−01 TCGA−AA−A01F−01 TCGA−AA−A00Q−01 TCGA−AA−A00K−01 TCGA−AA−A00A−01 TCGA−AA−3994−01 TCGA−AA−3975−01 TCGA−AA−3941−01 TCGA−AA−3939−01 TCGA−AA−3930−01 TCGA−AA−3854−01 TCGA−AA−3852−01 TCGA−AA−3851−01 TCGA−AA−3848−01 TCGA−AA−3844−01 TCGA−AA−3842−01 TCGA−AA−3837−01 TCGA−AA−3818−01 TCGA−AA−3696−01 TCGA−AA−3695−01 TCGA−AA−3681−01 TCGA−AA−3680−01 TCGA−AA−3673−01 TCGA−AA−3660−01 TCGA−AA−3655−01 TCGA−AA−3561−01 TCGA−AA−3560−01 TCGA−AA−3556−01 TCGA−AA−3548−01 TCGA−AA−3532−01 TCGA−AA−3530−01 TCGA−AA−3522−01 TCGA−AA−3521−01 TCGA−AA−3520−01 TCGA−AA−3511−01 TCGA−AA−3502−01 TCGA−A6−6782−01 TCGA−A6−6654−01 TCGA−A6−5664−01 TCGA−A6−5659−01 TCGA−A6−4105−01 TCGA−A6−3808−01

FGFR2c Ligand Binding And Activation FDR = 0.0063%, FDR nod = 0.0079% FGFR2b Ligand Binding And Activation FDR = 9.7e−05%, FDR nod = 0.00016%

TCGA−CA−6718−01 TCGA−D5−6924−01 TCGA−F4−6703−01 TCGA−AZ−4315−01 TCGA−DY−A1DC−01 TCGA−AA−A01R−01 TCGA−D5−5538−01 TCGA−AU−6004−01 TCGA−CK−5916−01 TCGA−AY−6197−01 TCGA−AA−A00N−01 TCGA−AA−3984−01 TCGA−D5−6920−01 TCGA−D5−5539−01 TCGA−AA−A01K−01 TCGA−AA−A010−01 TCGA−G4−6309−01 TCGA−CI−6622−01 TCGA−AG−A02N−01 TCGA−AA−3977−01 TCGA−CM−5861−01 TCGA−AD−6895−01 TCGA−CM−6171−01 TCGA−F5−6813−01 TCGA−CM−6162−01 TCGA−AA−3949−01 TCGA−G4−6588−01 TCGA−CA−6717−01 TCGA−AG−A002−01 TCGA−CM−4743−01 TCGA−AZ−6601−01 TCGA−AZ−6598−01 TCGA−AA−3713−01 TCGA−G5−6235−01 TCGA−G4−6628−01 TCGA−G4−6625−01 TCGA−G4−6323−01 TCGA−G4−6317−01 TCGA−G4−6304−01 TCGA−F5−6811−01 TCGA−F4−6570−01 TCGA−EI−6506−01 TCGA−DY−A0XA−01 TCGA−DM−A28G−01 TCGA−DM−A28F−01 TCGA−DM−A1DB−01 TCGA−DM−A1D6−01 TCGA−DM−A0XF−01 TCGA−D5−6898−01 TCGA−D5−6540−01 TCGA−D5−6539−01 TCGA−D5−6537−01 TCGA−D5−6535−01 TCGA−D5−6529−01 TCGA−CM−6168−01 TCGA−CM−5862−01 TCGA−CM−5348−01 TCGA−CM−4752−01 TCGA−CK−4952−01 TCGA−CK−4950−01 TCGA−AZ−6600−01 TCGA−AZ−6599−01 TCGA−AY−6386−01 TCGA−AY−6196−01 TCGA−AG−3892−01 TCGA−AF−6655−01 TCGA−AF−2693−01 TCGA−AD−6901−01 TCGA−AD−6889−01 TCGA−AA−3710−01 TCGA−AA−3663−01 TCGA−AA−3660−01 TCGA−AA−3510−01 TCGA−AA−3489−01 TCGA−A6−6142−01 TCGA−A6−6138−01 TCGA−A6−5666−01 TCGA−A6−5662−01 TCGA−A6−5660−01

TCGA−A6−6141−01 TCGA−CA−6718−01 TCGA−AA−3947−01 TCGA−AZ−4315−01 TCGA−AA−A010−01 TCGA−AA−A00N−01 TCGA−G4−6309−01 TCGA−G4−6293−01 TCGA−AA−3516−01 TCGA−AA−3502−01 TCGA−CM−6171−01 TCGA−D5−5538−01 TCGA−AU−6004−01 TCGA−AD−6895−01 TCGA−DM−A1D4−01 TCGA−CK−5916−01 TCGA−AY−6197−01 TCGA−AA−3845−01 TCGA−AA−3518−01 TCGA−A6−6781−01 TCGA−G4−6628−01 TCGA−G4−6588−01 TCGA−D5−6529−01 TCGA−AZ−6601−01 TCGA−AZ−6598−01 TCGA−AA−3510−01 TCGA−G5−6235−01 TCGA−G4−6625−01 TCGA−G4−6323−01 TCGA−G4−6317−01 TCGA−G4−6304−01 TCGA−F5−6811−01 TCGA−F4−6570−01 TCGA−EI−6506−01 TCGA−DY−A0XA−01 TCGA−DM−A28G−01 TCGA−DM−A28F−01 TCGA−DM−A1DB−01 TCGA−DM−A1D6−01 TCGA−DM−A0XF−01 TCGA−D5−6898−01 TCGA−D5−6540−01 TCGA−D5−6539−01 TCGA−D5−6537−01 TCGA−D5−6535−01 TCGA−CM−6168−01 TCGA−CM−5862−01 TCGA−CM−5348−01 TCGA−CM−4752−01 TCGA−CM−4743−01 TCGA−CK−4952−01 TCGA−CK−4950−01 TCGA−CA−6717−01 TCGA−AZ−6600−01 TCGA−AZ−6599−01 TCGA−AY−6386−01 TCGA−AY−6196−01 TCGA−AG−A002−01 TCGA−AG−3892−01 TCGA−AF−6655−01 TCGA−AF−2693−01 TCGA−AD−6901−01 TCGA−AD−6889−01 TCGA−AA−3713−01 TCGA−AA−3710−01 TCGA−AA−3663−01 TCGA−AA−3660−01 TCGA−AA−3489−01 TCGA−A6−6142−01 TCGA−A6−6138−01 TCGA−A6−5666−01 TCGA−A6−5662−01 TCGA−A6−5660−01

GRB2:SOS Provides Linkage To MAPK Signaling For Integrins FDR = 0.064%, FDR nod = 4.4% G Beta:gamma Signalling Through PI3Kgamma FDR = 1.9e−12%, FDR nod = 0.45%


FN1


VWF

PTK2

TLN1

wt wt

APBB1IP

FGA

SOS1

ITGB3

GRB2

SRC

FGB

FGG

ITGA2B

RAP1A

RAP1B

PIK3CA PIK3R1 PIK3CG JAK3 JAK2 GAB2 AKT1 RHOA IL2RB PIK3CD AKT2 GNB3 GNB4 GRB2 IL3 IL3RA AKT3 CSF2RA GNGT1 IL2 JAK1 PIK3CB PIK3R2 PIK3R3 PIK3R5 CSF2RB GNB1 GNB2 GNB5 GNG11 GNG12 GNG3 GNG4 GNG7 IL2RA IL2RG IL5RA PDPK1 PIK3R6 SHC1

wt wt

FGFR1 PLCG1


FGFR2 MAP2K4

PIK3CA

unknown CG mut KRAS

unknown CG mut NRAS VAV3

PLCG1 VAV1

MAPK8 SHC1

FGFR3 MAPK10 PLCG2

SHC1 GRB2

MAP2K7

AKT1 PAK1

PAK2

FGFR4 SOS1

GRAP2

MAPK1 HRAS JUN

MAPK14 MAPK9 SYK

SOS1 FOS LAT

FGF1 LCP2 LYN

FRS2 MAPK1

MAPK3

MAPK3 RAC1 VAV2

unknown CG mut unknown CG mut FGFR2

FGFR2

FGFBP1

wt FGF6 wt

known HCG mut FGF23 known HCG mut

FGF5

FGF2

FGF3

FGF18

FGF2

FGF1

FGF8

FGF7

FGF1

FGF16

FGF10

FGF17

FGF22

FGF20

FGF9

TCGA−AA−3966−01 TCGA−AA−3562−01 TCGA−AA−3555−01 TCGA−DC−6158−01 TCGA−CM−6167−01 TCGA−AD−6899−01 TCGA−AA−A00K−01 TCGA−AA−3815−01 TCGA−D5−6538−01 TCGA−DM−A1DA−01 TCGA−AA−3543−01 TCGA−F5−6813−01 TCGA−D5−6929−01 TCGA−AF−5654−01 TCGA−AA−3984−01 TCGA−AA−3662−01 TCGA−AA−3977−01 TCGA−F5−6811−01 TCGA−F4−6703−01 TCGA−D5−6536−01 TCGA−CK−4948−01 TCGA−CI−6622−01 TCGA−AG−3601−01 TCGA−AA−3949−01 TCGA−AF−6136−01 TCGA−AA−A00R−01 TCGA−G5−6235−01 TCGA−CM−6169−01 TCGA−CK−4952−01 TCGA−CK−4950−01 TCGA−AA−A00A−01 TCGA−AA−3666−01 TCGA−AA−3525−01 TCGA−AD−6895−01 TCGA−AD−6964−01 TCGA−DM−A28E−01 TCGA−CM−5344−01 TCGA−AG−3598−01 TCGA−AD−6965−01 TCGA−AA−3994−01 TCGA−AA−3814−01 TCGA−AA−3697−01 TCGA−A6−4105−01 TCGA−G4−6628−01 TCGA−AA−A01Q−01 TCGA−AA−3947−01 TCGA−AA−3712−01 TCGA−AA−3663−01 TCGA−A6−6781−01 TCGA−F4−6806−01 TCGA−D5−6539−01 TCGA−CA−6716−01 TCGA−AD−6889−01 TCGA−AA−A02O−01 TCGA−AA−3952−01 TCGA−A6−5657−01 TCGA−AZ−6599−01 TCGA−AZ−5407−01 TCGA−AA−3877−01 TCGA−AA−3821−01 TCGA−G4−6303−01 TCGA−G4−6299−01 TCGA−DM−A0XF−01 TCGA−D5−6931−01 TCGA−D5−6920−01 TCGA−D5−5538−01 TCGA−CM−5861−01 TCGA−CK−6747−01 TCGA−CA−6718−01 TCGA−AY−5543−01 TCGA−A6−5665−01 TCGA−AA−3672−01 TCGA−AG−A02N−01 TCGA−AA−3510−01 TCGA−A6−6780−01 TCGA−G4−6625−01 TCGA−G4−6586−01 TCGA−F4−6570−01 TCGA−D5−6534−01 TCGA−AY−6197−01 TCGA−AA−3516−01 TCGA−G4−6309−01 TCGA−DY−A1DC−01 TCGA−DM−A28G−01 TCGA−CM−6676−01 TCGA−CA−5254−01 TCGA−AZ−6607−01 TCGA−AG−A026−01 TCGA−AG−3892−01 TCGA−AA−A00O−01 TCGA−A6−6653−01 TCGA−AG−A002−01 TCGA−AA−A010−01 TCGA−CA−6717−01 TCGA−AZ−4315−01 TCGA−AA−A00N−01 TCGA−AA−3715−01 TCGA−G4−6588−01 TCGA−D5−6540−01 TCGA−CM−6171−01 TCGA−AZ−6601−01 TCGA−AZ−6598−01 TCGA−AU−3779−01 TCGA−AA−3950−01 TCGA−A6−5661−01 TCGA−F4−6807−01 TCGA−DC−6682−01 TCGA−D5−6930−01 TCGA−CK−5914−01 TCGA−CK−5913−01 TCGA−AG−3593−01 TCGA−AD−5900−01 TCGA−AA−3811−01 TCGA−G4−6315−01 TCGA−F5−6812−01 TCGA−DM−A0X9−01 TCGA−D5−6928−01 TCGA−CM−6165−01 TCGA−CM−5349−01 TCGA−CA−6719−01 TCGA−AG−4005−01 TCGA−AD−6901−01 TCGA−AA−A01R−01 TCGA−AA−A01D−01 TCGA−AA−3989−01 TCGA−AA−3972−01 TCGA−AA−3852−01 TCGA−AA−3845−01 TCGA−AA−3713−01 TCGA−AA−3660−01 TCGA−AA−3518−01 TCGA−AA−3502−01 TCGA−AA−3492−01 TCGA−A6−5666−01 TCGA−A6−3810−01 TCGA−A6−3808−01 TCGA−A6−2676−01

TCGA−AA−3979−01 TCGA−AA−3949−01 TCGA−AF−2689−01 TCGA−AA−3695−01 TCGA−DY−A1DF−01 TCGA−AA−3710−01 TCGA−AA−3553−01 TCGA−AG−4005−01 TCGA−AG−3999−01 TCGA−D5−6535−01 TCGA−F4−6703−01 TCGA−AF−5654−01 TCGA−AA−A00A−01 TCGA−AA−3672−01 TCGA−DM−A1DA−01 TCGA−AA−3543−01 TCGA−DC−6155−01 TCGA−AA−3856−01 TCGA−AA−A00J−01 TCGA−AA−3558−01 TCGA−AA−3968−01 TCGA−AA−3542−01 TCGA−CM−4744−01 TCGA−CA−6715−01 TCGA−AA−3518−01 TCGA−D5−6928−01 TCGA−AG−A032−01 TCGA−AA−3821−01 TCGA−AA−A01R−01 TCGA−AA−A01P−01 TCGA−AA−3845−01 TCGA−AA−3972−01 TCGA−AD−6889−01 TCGA−D5−5537−01 TCGA−AA−3516−01 TCGA−AZ−6605−01 TCGA−AA−A01Q−01 TCGA−G4−6306−01 TCGA−DM−A282−01 TCGA−DC−6681−01 TCGA−AA−3861−01 TCGA−CM−6170−01 TCGA−AY−6196−01 TCGA−F4−6704−01 TCGA−CM−5868−01 TCGA−AZ−6607−01 TCGA−AA−A02K−01 TCGA−CK−5913−01 TCGA−AA−A022−01 TCGA−AA−A00E−01 TCGA−AG−3608−01 TCGA−AA−3555−01 TCGA−A6−6651−01 TCGA−A6−6648−01 TCGA−D5−6533−01 TCGA−CM−5348−01 TCGA−CK−5915−01 TCGA−AA−3966−01 TCGA−AA−3811−01 TCGA−A6−6653−01 TCGA−CM−6677−01 TCGA−CM−5341−01 TCGA−AD−6901−01 TCGA−AA−3534−01 TCGA−AA−3525−01 TCGA−A6−2676−01 TCGA−AG−A002−01 TCGA−A6−6781−01 TCGA−AD−6895−01 TCGA−AA−3984−01 TCGA−G4−6309−01 TCGA−AG−3892−01 TCGA−EI−6508−01 TCGA−CM−6167−01 TCGA−AA−3833−01 TCGA−G4−6626−01 TCGA−D5−6922−01 TCGA−AH−6549−01 TCGA−AG−A025−01 TCGA−AG−3726−01 TCGA−AA−3664−01 TCGA−AA−3552−01 TCGA−CA−6717−01 TCGA−AA−A010−01 TCGA−G4−6586−01 TCGA−AZ−4315−01 TCGA−EI−6507−01 TCGA−AZ−6601−01 TCGA−AZ−6598−01 TCGA−AA−3977−01 TCGA−G4−6628−01 TCGA−CM−4752−01 TCGA−CM−4746−01 TCGA−CK−4952−01 TCGA−CA−6718−01 TCGA−AA−A00N−01 TCGA−A6−5665−01 TCGA−G4−6315−01 TCGA−DY−A1DG−01 TCGA−CM−6171−01 TCGA−CM−6162−01 TCGA−CM−5862−01 TCGA−CM−5861−01 TCGA−CK−6746−01 TCGA−CK−5916−01 TCGA−AZ−6608−01 TCGA−AY−6197−01 TCGA−AU−6004−01 TCGA−AD−6964−01 TCGA−AD−5900−01 TCGA−AA−3947−01 TCGA−AA−3877−01 TCGA−AA−3815−01 TCGA−AA−3715−01 TCGA−AA−3662−01 TCGA−AA−3492−01 TCGA−A6−6780−01 TCGA−A6−5661−01 TCGA−G4−6625−01 TCGA−G4−6588−01 TCGA−G4−6317−01 TCGA−G4−6310−01 TCGA−G4−6307−01 TCGA−F4−6570−01 TCGA−EF−5830−01 TCGA−DM−A1DB−01 TCGA−DM−A0XD−01 TCGA−D5−6927−01 TCGA−D5−6540−01 TCGA−D5−6532−01 TCGA−CM−6678−01 TCGA−CM−6674−01 TCGA−CM−6169−01 TCGA−CM−6161−01 TCGA−CM−4743−01 TCGA−CK−4950−01 TCGA−CK−4948−01 TCGA−AY−5543−01 TCGA−AG−A02N−01 TCGA−AA−3950−01 TCGA−AA−3864−01 TCGA−AA−3713−01 TCGA−AA−3697−01 TCGA−AA−3660−01 TCGA−A6−5662−01 TCGA−G4−6304−01 TCGA−G4−6303−01 TCGA−G4−6293−01 TCGA−F4−6854−01 TCGA−F4−6808−01 TCGA−F4−6807−01 TCGA−F4−6569−01 TCGA−F4−6460−01 TCGA−F4−6459−01 TCGA−DM−A28H−01 TCGA−DM−A1D9−01 TCGA−DC−6683−01 TCGA−DC−6158−01 TCGA−DC−5869−01 TCGA−D5−6929−01 TCGA−D5−6541−01 TCGA−D5−6538−01 TCGA−D5−6537−01 TCGA−D5−6536−01 TCGA−D5−6534−01 TCGA−D5−5541−01 TCGA−D5−5540−01 TCGA−CM−6168−01 TCGA−CM−6166−01 TCGA−CM−6164−01 TCGA−CM−5864−01 TCGA−CM−5860−01 TCGA−CK−5914−01 TCGA−CI−6622−01 TCGA−CA−6719−01 TCGA−AZ−6606−01 TCGA−AZ−5407−01 TCGA−AZ−5403−01 TCGA−AZ−4616−01 TCGA−AY−6386−01 TCGA−AU−3779−01 TCGA−AH−6644−01 TCGA−AG−3742−01 TCGA−AF−6672−01 TCGA−AF−6136−01 TCGA−AA−3956−01 TCGA−AA−3837−01 TCGA−AA−3712−01 TCGA−AA−3663−01 TCGA−AA−3511−01 TCGA−A6−6654−01 TCGA−A6−6649−01 TCGA−A6−6141−01 TCGA−A6−5666−01 TCGA−A6−5660−01 TCGA−A6−5657−01 TCGA−A6−5656−01 TCGA−G5−6235−01 TCGA−G4−6323−01 TCGA−G4−6299−01 TCGA−F5−6813−01 TCGA−F5−6811−01 TCGA−F5−6571−01 TCGA−F4−6856−01 TCGA−F4−6855−01 TCGA−F4−6809−01 TCGA−F4−6805−01 TCGA−DY−A1DC−01 TCGA−DY−A0XA−01 TCGA−DT−5265−01 TCGA−DM−A28G−01 TCGA−DM−A28C−01 TCGA−DM−A285−01 TCGA−DM−A1HA−01 TCGA−DM−A1D8−01 TCGA−DM−A1D7−01 TCGA−DM−A0XF−01 TCGA−DM−A0X9−01 TCGA−DC−6682−01 TCGA−DC−6160−01 TCGA−DC−6157−01 TCGA−D5−7000−01 TCGA−D5−6931−01 TCGA−D5−6926−01 TCGA−D5−6923−01 TCGA−D5−6920−01 TCGA−D5−6898−01 TCGA−D5−6529−01 TCGA−D5−5539−01 TCGA−D5−5538−01 TCGA−CM−6680−01 TCGA−CM−6676−01 TCGA−CM−6172−01 TCGA−CM−5349−01 TCGA−CM−5344−01 TCGA−CM−4747−01 TCGA−CL−5918−01 TCGA−CL−5917−01 TCGA−CK−6747−01 TCGA−CK−5912−01 TCGA−CK−4947−01 TCGA−CI−6624−01 TCGA−CI−6619−01 TCGA−AZ−6599−01 TCGA−AZ−4682−01 TCGA−AH−6643−01 TCGA−AH−6544−01 TCGA−AG−A020−01 TCGA−AG−A00H−01 TCGA−AG−4015−01 TCGA−AG−3901−01 TCGA−AG−3887−01 TCGA−AG−3878−01 TCGA−AG−3731−01 TCGA−AF−2693−01 TCGA−AF−2687−01 TCGA−AD−6965−01 TCGA−AD−6963−01 TCGA−AD−6899−01 TCGA−AD−6890−01 TCGA−AD−6548−01 TCGA−AA−A03J−01 TCGA−AA−A03F−01 TCGA−AA−A02Y−01 TCGA−AA−A02O−01 TCGA−AA−A01V−01 TCGA−AA−A01K−01 TCGA−AA−A01I−01 TCGA−AA−3939−01 TCGA−AA−3866−01 TCGA−AA−3852−01 TCGA−AA−3850−01 TCGA−AA−3848−01 TCGA−AA−3818−01 TCGA−AA−3812−01 TCGA−AA−3696−01 TCGA−AA−3673−01 TCGA−AA−3655−01 TCGA−AA−3510−01 TCGA−AA−3496−01 TCGA−AA−3489−01 TCGA−A6−6782−01 TCGA−A6−6652−01 TCGA−A6−5659−01 TCGA−A6−4105−01 TCGA−A6−3809−01 TCGA−A6−3808−01

TCGA−D5−6931−01 TCGA−D5−5537−01 TCGA−AA−3558−01 TCGA−F4−6856−01 TCGA−AA−A01V−01 TCGA−AA−3562−01 TCGA−AA−3815−01 TCGA−AA−3555−01 TCGA−A6−6780−01 TCGA−AG−3726−01 TCGA−AA−3688−01 TCGA−AA−3673−01 TCGA−D5−6533−01 TCGA−AG−3609−01 TCGA−AA−3526−01 TCGA−CM−6678−01 TCGA−CK−5916−01 TCGA−AA−3518−01 TCGA−A6−6651−01 TCGA−D5−5540−01 TCGA−CM−6167−01 TCGA−AU−6004−01 TCGA−AA−3989−01 TCGA−AA−3502−01 TCGA−AZ−6601−01 TCGA−CM−4743−01 TCGA−AZ−6599−01 TCGA−D5−6537−01 TCGA−D5−5541−01 TCGA−AA−3666−01 TCGA−F5−6702−01 TCGA−DY−A0XA−01 TCGA−D5−7000−01 TCGA−AG−A032−01 TCGA−AA−A00R−01 TCGA−AA−3845−01 TCGA−AA−3662−01 TCGA−AA−3514−01 TCGA−AA−A00N−01 TCGA−DM−A28H−01 TCGA−AA−3977−01 TCGA−G4−6307−01 TCGA−F4−6704−01 TCGA−DM−A28G−01 TCGA−CM−5344−01 TCGA−AY−5543−01 TCGA−AG−A00C−01 TCGA−A6−6652−01 TCGA−D5−6541−01 TCGA−AA−A00E−01 TCGA−AA−3695−01 TCGA−AA−3672−01 TCGA−DM−A0X9−01 TCGA−DC−6157−01 TCGA−CM−6165−01 TCGA−CK−6751−01 TCGA−CI−6621−01 TCGA−AG−3593−01 TCGA−AA−3872−01 TCGA−AA−3812−01 TCGA−A6−6782−01 TCGA−AZ−4315−01 TCGA−AA−3984−01 TCGA−A6−6781−01 TCGA−AA−3663−01 TCGA−AA−A01R−01 TCGA−F5−6571−01 TCGA−EI−6507−01 TCGA−DC−6682−01 TCGA−D5−6932−01 TCGA−CM−6164−01 TCGA−AH−6643−01 TCGA−AH−6549−01 TCGA−AA−3852−01 TCGA−AA−3697−01 TCGA−AA−3549−01 TCGA−AA−3527−01 TCGA−AA−3496−01 TCGA−AA−A010−01 TCGA−CM−4746−01 TCGA−G4−6309−01 TCGA−CK−4952−01 TCGA−AZ−6600−01 TCGA−AA−3864−01 TCGA−AA−3710−01 TCGA−AA−3510−01 TCGA−A6−6141−01 TCGA−G5−6235−01 TCGA−DY−A1H8−01 TCGA−AY−6197−01 TCGA−AG−3909−01 TCGA−AG−3881−01 TCGA−AA−A01Z−01 TCGA−AA−3811−01 TCGA−AA−3655−01 TCGA−A6−5666−01 TCGA−A6−3809−01 TCGA−AG−A002−01 TCGA−CA−6717−01 TCGA−A6−5665−01 TCGA−G4−6588−01 TCGA−AD−6889−01 TCGA−CM−6674−01 TCGA−CM−6168−01 TCGA−CK−5913−01 TCGA−AZ−6598−01 TCGA−A6−5661−01 TCGA−G4−6628−01 TCGA−G4−6586−01 TCGA−D5−6930−01 TCGA−D5−6540−01 TCGA−CM−6171−01 TCGA−CM−6169−01 TCGA−CM−6162−01 TCGA−CK−4947−01 TCGA−AZ−5407−01 TCGA−AD−5900−01 TCGA−AA−A00J−01 TCGA−AA−3966−01 TCGA−AA−3947−01 TCGA−AA−3877−01 TCGA−AA−3715−01 TCGA−AA−3492−01 TCGA−A6−6653−01 TCGA−G4−6299−01 TCGA−F5−6811−01 TCGA−F4−6460−01 TCGA−DM−A1DA−01 TCGA−DM−A1D4−01 TCGA−DC−6158−01 TCGA−D5−6535−01 TCGA−D5−6529−01 TCGA−D5−5538−01 TCGA−CA−6718−01 TCGA−AY−6196−01 TCGA−AG−3885−01 TCGA−AD−6964−01 TCGA−AD−6963−01 TCGA−AA−A022−01 TCGA−AA−3950−01 TCGA−AA−3949−01 TCGA−AA−3821−01 TCGA−AA−3516−01 TCGA−A6−2676−01 TCGA−A6−2672−01 TCGA−G4−6626−01 TCGA−G4−6625−01 TCGA−G4−6323−01 TCGA−G4−6321−01 TCGA−G4−6310−01 TCGA−G4−6303−01 TCGA−F4−6570−01 TCGA−EI−6510−01 TCGA−EI−6508−01 TCGA−EF−5830−01 TCGA−DY−A1DD−01 TCGA−DT−5265−01 TCGA−DM−A28C−01 TCGA−DM−A285−01 TCGA−DM−A1D7−01 TCGA−DM−A1D6−01 TCGA−DM−A0XF−01 TCGA−DM−A0XD−01 TCGA−DC−6683−01 TCGA−DC−6681−01 TCGA−DC−6160−01 TCGA−D5−6928−01 TCGA−D5−6539−01 TCGA−D5−6536−01 TCGA−D5−6534−01 TCGA−CM−6675−01 TCGA−CM−6170−01 TCGA−CM−5868−01 TCGA−CM−5864−01 TCGA−CM−5861−01 TCGA−CM−5860−01 TCGA−CM−5349−01 TCGA−CM−5348−01 TCGA−CM−4744−01 TCGA−CK−6747−01 TCGA−CK−5914−01 TCGA−CK−4950−01 TCGA−CA−5796−01 TCGA−AZ−6606−01 TCGA−AZ−6603−01 TCGA−AG−3578−01 TCGA−AD−6895−01 TCGA−AA−A01P−01 TCGA−AA−A01D−01 TCGA−AA−A00D−01 TCGA−AA−3833−01 TCGA−AA−3713−01 TCGA−AA−3712−01 TCGA−AA−3684−01 TCGA−AA−3664−01 TCGA−AA−3543−01 TCGA−AA−3525−01 TCGA−A6−6649−01 TCGA−A6−5664−01 TCGA−A6−5657−01

TCGA−AA−3663−01 TCGA−D5−6927−01 TCGA−AG−3892−01 TCGA−AA−3715−01 TCGA−AA−3510−01 TCGA−A6−6653−01 TCGA−G4−6628−01 TCGA−D5−6540−01 TCGA−CM−6162−01 TCGA−A6−6780−01 TCGA−A6−3809−01 TCGA−F4−6460−01 TCGA−D5−6931−01 TCGA−AZ−4315−01 TCGA−AA−A00E−01 TCGA−AA−3870−01 TCGA−AA−3710−01 TCGA−A6−6781−01 TCGA−EI−6507−01 TCGA−DT−5265−01 TCGA−D5−6930−01 TCGA−D5−5537−01 TCGA−AZ−5403−01 TCGA−AY−6197−01 TCGA−G4−6588−01 TCGA−G4−6303−01 TCGA−AZ−6601−01 TCGA−AZ−6599−01 TCGA−AD−6964−01 TCGA−G4−6310−01 TCGA−G4−6307−01 TCGA−G4−6306−01 TCGA−G4−6299−01 TCGA−DY−A1H8−01 TCGA−DY−A1DD−01 TCGA−DY−A1DC−01 TCGA−DY−A0XA−01 TCGA−DM−A28F−01 TCGA−DM−A1HA−01 TCGA−DM−A0X9−01 TCGA−D5−6538−01 TCGA−D5−6535−01 TCGA−D5−6534−01 TCGA−CM−6676−01 TCGA−CM−6675−01 TCGA−CK−6747−01 TCGA−CK−5915−01 TCGA−CK−5914−01 TCGA−AZ−6608−01 TCGA−AH−6643−01 TCGA−AG−A036−01 TCGA−AG−4015−01 TCGA−AF−4110−01 TCGA−AF−2693−01 TCGA−AA−3977−01 TCGA−AA−3712−01 TCGA−AA−3697−01 TCGA−AA−3655−01 TCGA−AA−3555−01 TCGA−AG−A002−01 TCGA−CA−6717−01 TCGA−AZ−6598−01 TCGA−AU−6004−01 TCGA−AA−A010−01 TCGA−AA−A00N−01 TCGA−CM−5862−01 TCGA−CM−4746−01 TCGA−CK−6746−01 TCGA−CA−6718−01 TCGA−AY−6196−01 TCGA−AA−3950−01 TCGA−AA−3815−01 TCGA−AA−3713−01 TCGA−AA−3660−01 TCGA−G4−6625−01 TCGA−G4−6309−01 TCGA−G4−6293−01 TCGA−F4−6807−01 TCGA−F4−6704−01 TCGA−F4−6569−01 TCGA−EI−6508−01 TCGA−EF−5830−01 TCGA−DM−A0XD−01 TCGA−DC−6683−01 TCGA−DC−5869−01 TCGA−D5−6929−01 TCGA−D5−6541−01 TCGA−D5−6533−01 TCGA−D5−6532−01 TCGA−CM−6170−01 TCGA−CM−6169−01 TCGA−CM−6161−01 TCGA−CM−5868−01 TCGA−CM−5860−01 TCGA−CA−6719−01 TCGA−AZ−6607−01 TCGA−AZ−6606−01 TCGA−AZ−4616−01 TCGA−AY−5543−01 TCGA−AF−6672−01 TCGA−AA−A02K−01 TCGA−AA−3984−01 TCGA−AA−3966−01 TCGA−AA−3662−01 TCGA−A6−5666−01 TCGA−A6−5665−01 TCGA−A6−5662−01

JAK/STAT Signaling Pathway FDR = 0.06%, FDR nod = 0.048% IL2 Signaling Events Mediated By PI3K FDR = 2e−12%, FDR nod = 4.8%

TCGA−AA−3562−01 TCGA−AA−3947−01 TCGA−DT−5265−01 TCGA−D5−6930−01 TCGA−D5−5537−01 TCGA−A6−6653−01 TCGA−G4−6303−01 TCGA−D5−6540−01 TCGA−A6−3809−01 TCGA−DM−A28K−01 TCGA−DM−A1DA−01 TCGA−CK−5916−01 TCGA−AG−A00C−01 TCGA−DM−A1HA−01 TCGA−D5−6536−01 TCGA−AU−3779−01 TCGA−AA−3514−01 TCGA−D5−5539−01 TCGA−AZ−6601−01 TCGA−AA−A01K−01 TCGA−AA−3561−01 TCGA−AA−3864−01 TCGA−AA−3715−01 TCGA−DC−6158−01 TCGA−CM−4743−01 TCGA−CI−6624−01 TCGA−AA−A01R−01 TCGA−A6−6141−01 TCGA−D5−6928−01 TCGA−CM−6162−01 TCGA−EI−6507−01 TCGA−CK−4948−01 TCGA−AY−6197−01 TCGA−AD−6964−01 TCGA−A6−6781−01 TCGA−CM−6171−01 TCGA−AD−6895−01 TCGA−AA−A01P−01 TCGA−G4−6628−01 TCGA−AD−5900−01 TCGA−AA−3510−01 TCGA−F4−6570−01 TCGA−AZ−4315−01 TCGA−AG−3892−01 TCGA−AD−6889−01 TCGA−AA−3710−01 TCGA−A6−6780−01 TCGA−A6−5661−01 TCGA−A6−5657−01 TCGA−F5−6812−01 TCGA−F4−6460−01 TCGA−AD−6901−01 TCGA−AA−A00J−01 TCGA−AA−3956−01 TCGA−AA−3845−01 TCGA−A6−6142−01 TCGA−AA−3977−01 TCGA−G4−6588−01 TCGA−AZ−5403−01 TCGA−G4−6586−01 TCGA−CK−4952−01 TCGA−AG−A02N−01 TCGA−AA−A022−01 TCGA−AA−A00E−01 TCGA−AA−3877−01 TCGA−AA−3555−01 TCGA−G4−6310−01 TCGA−G4−6307−01 TCGA−DY−A1DG−01 TCGA−DM−A28H−01 TCGA−D5−6537−01 TCGA−CM−4752−01 TCGA−CK−5915−01 TCGA−CK−5913−01 TCGA−AZ−5407−01 TCGA−AG−3742−01 TCGA−AG−3608−01 TCGA−A6−6651−01 TCGA−A6−6648−01 TCGA−CA−6717−01 TCGA−AG−A002−01 TCGA−AA−A010−01 TCGA−CA−6718−01 TCGA−AU−6004−01 TCGA−CM−5860−01 TCGA−CK−6746−01 TCGA−AZ−6598−01 TCGA−AY−6196−01 TCGA−AA−3660−01 TCGA−D5−6532−01 TCGA−CM−4746−01 TCGA−AA−A00N−01 TCGA−AA−3984−01 TCGA−AA−3950−01 TCGA−AA−3815−01 TCGA−AA−3713−01 TCGA−AA−3662−01 TCGA−A6−5665−01 TCGA−A6−5662−01 TCGA−G4−6625−01 TCGA−G4−6309−01 TCGA−G4−6293−01 TCGA−F4−6807−01 TCGA−F4−6704−01 TCGA−F4−6569−01 TCGA−EI−6508−01 TCGA−EF−5830−01 TCGA−DM−A0XD−01 TCGA−DC−6683−01 TCGA−DC−5869−01 TCGA−D5−6929−01 TCGA−D5−6541−01 TCGA−D5−6533−01 TCGA−CM−6170−01 TCGA−CM−6169−01 TCGA−CM−6161−01 TCGA−CM−5868−01 TCGA−CM−5862−01 TCGA−CA−6719−01 TCGA−AZ−6607−01 TCGA−AZ−6606−01 TCGA−AZ−4616−01 TCGA−AY−5543−01 TCGA−AF−6672−01 TCGA−AA−A02K−01 TCGA−AA−3966−01 TCGA−A6−5666−01

TCGA−AA−A01D−01 TCGA−AG−3601−01 TCGA−D5−6930−01 TCGA−A6−6653−01 TCGA−A6−2676−01 TCGA−AY−6196−01 TCGA−CI−6621−01 TCGA−AA−3845−01 TCGA−AG−3608−01 TCGA−A6−6648−01 TCGA−D5−6928−01 TCGA−AG−A032−01 TCGA−AA−A01R−01 TCGA−AA−3553−01 TCGA−DM−A1DA−01 TCGA−AA−3543−01 TCGA−DC−6681−01 TCGA−AA−3861−01 TCGA−F4−6703−01 TCGA−CK−6751−01 TCGA−AA−3561−01 TCGA−AZ−6605−01 TCGA−AD−6889−01 TCGA−AA−3516−01 TCGA−D5−5537−01 TCGA−D5−6533−01 TCGA−CK−5913−01 TCGA−AA−A01Q−01 TCGA−AA−3811−01 TCGA−AA−3979−01 TCGA−AA−A01P−01 TCGA−D5−6932−01 TCGA−AG−3883−01 TCGA−AF−3913−01 TCGA−AA−A02K−01 TCGA−AA−3518−01 TCGA−AA−A022−01 TCGA−AA−A00E−01 TCGA−CM−4744−01 TCGA−AA−A00R−01 TCGA−AA−3554−01 TCGA−A6−6142−01 TCGA−D5−6535−01 TCGA−G4−6306−01 TCGA−DY−A1DD−01 TCGA−CK−5915−01 TCGA−DY−A1H8−01 TCGA−DM−A28F−01 TCGA−CM−6675−01 TCGA−AG−A036−01 TCGA−AF−4110−01 TCGA−AD−6895−01 TCGA−AA−3833−01 TCGA−AA−3664−01 TCGA−G4−6626−01 TCGA−EI−6508−01 TCGA−D5−6922−01 TCGA−CM−6167−01 TCGA−AH−6549−01 TCGA−AG−A025−01 TCGA−AG−3726−01 TCGA−AA−3552−01 TCGA−AG−A002−01 TCGA−A6−6781−01 TCGA−AA−3984−01 TCGA−AA−3949−01 TCGA−G4−6309−01 TCGA−AA−3821−01 TCGA−AA−3710−01 TCGA−AA−3555−01 TCGA−DM−A28K−01 TCGA−DM−A282−01 TCGA−AG−3892−01 TCGA−AA−3854−01 TCGA−A6−6651−01 TCGA−F4−6806−01 TCGA−DM−A1D4−01 TCGA−CA−6716−01 TCGA−AA−A00K−01 TCGA−AA−3980−01 TCGA−AA−3867−01 TCGA−AA−3666−01 TCGA−AA−A010−01 TCGA−CA−6717−01 TCGA−AZ−4315−01 TCGA−G4−6588−01 TCGA−G4−6586−01 TCGA−AA−3977−01 TCGA−EI−6507−01 TCGA−CM−6171−01 TCGA−AZ−6598−01 TCGA−G4−6307−01 TCGA−D5−6540−01 TCGA−CM−4752−01 TCGA−AY−6197−01 TCGA−AU−6004−01 TCGA−AA−3877−01 TCGA−AA−3492−01 TCGA−A6−5665−01 TCGA−DM−A0X9−01 TCGA−CM−5861−01 TCGA−CK−5916−01 TCGA−CK−4952−01 TCGA−AZ−6608−01 TCGA−AH−6643−01 TCGA−AD−6964−01 TCGA−AA−A00N−01 TCGA−AA−3947−01 TCGA−AA−3715−01 TCGA−AA−3712−01 TCGA−AA−3663−01 TCGA−A6−5661−01 TCGA−G4−6628−01 TCGA−G4−6625−01 TCGA−G4−6310−01 TCGA−F5−6811−01 TCGA−F4−6856−01 TCGA−F4−6570−01 TCGA−DY−A1DG−01 TCGA−DM−A1D9−01 TCGA−D5−6927−01 TCGA−D5−6538−01 TCGA−D5−6536−01 TCGA−CM−6162−01 TCGA−CM−5862−01 TCGA−CM−4746−01 TCGA−CM−4743−01 TCGA−CK−5914−01 TCGA−CK−4948−01 TCGA−CA−6718−01 TCGA−AZ−6601−01 TCGA−AY−5543−01 TCGA−AG−A02N−01 TCGA−AA−3864−01 TCGA−AA−3815−01 TCGA−AA−3697−01 TCGA−AA−3662−01 TCGA−AA−3511−01 TCGA−AA−3510−01 TCGA−A6−6780−01 TCGA−A6−6141−01 TCGA−A6−5660−01 TCGA−A6−5659−01 TCGA−A6−4105−01 TCGA−G4−6315−01 TCGA−G4−6303−01 TCGA−G4−6299−01 TCGA−G4−6293−01 TCGA−F4−6460−01 TCGA−F4−6459−01 TCGA−EF−5830−01 TCGA−DY−A1DC−01 TCGA−DY−A0XA−01 TCGA−DT−5265−01 TCGA−DM−A28H−01 TCGA−DM−A28C−01 TCGA−DM−A1HA−01 TCGA−DM−A1DB−01 TCGA−DM−A0XD−01 TCGA−DC−6682−01 TCGA−D5−6541−01 TCGA−D5−6537−01 TCGA−D5−6534−01 TCGA−D5−6532−01 TCGA−D5−5541−01 TCGA−D5−5538−01 TCGA−CM−6680−01 TCGA−CM−6678−01 TCGA−CM−6676−01 TCGA−CM−6674−01 TCGA−CM−6169−01 TCGA−CM−6166−01 TCGA−CM−6164−01 TCGA−CM−6161−01 TCGA−CM−5864−01 TCGA−CM−5349−01 TCGA−CK−6747−01 TCGA−CK−6746−01 TCGA−CK−4950−01 TCGA−CI−6622−01 TCGA−AZ−6599−01 TCGA−AZ−5407−01 TCGA−AZ−5403−01 TCGA−AY−6386−01 TCGA−AU−3779−01 TCGA−AH−6644−01 TCGA−AG−4015−01 TCGA−AG−3742−01 TCGA−AF−6136−01 TCGA−AF−2693−01 TCGA−AF−2687−01 TCGA−AD−5900−01 TCGA−AA−3956−01 TCGA−AA−3950−01 TCGA−AA−3812−01 TCGA−AA−3660−01 TCGA−AA−3655−01 TCGA−AA−3496−01 TCGA−A6−6649−01 TCGA−A6−5666−01 TCGA−A6−5662−01 TCGA−A6−5657−01 TCGA−A6−5656−01 TCGA−A6−3809−01 TCGA−G5−6235−01 TCGA−G4−6323−01 TCGA−G4−6317−01 TCGA−G4−6304−01 TCGA−F5−6813−01 TCGA−F5−6571−01 TCGA−F4−6855−01 TCGA−F4−6854−01 TCGA−F4−6809−01 TCGA−F4−6808−01 TCGA−F4−6807−01 TCGA−F4−6805−01 TCGA−F4−6569−01 TCGA−DM−A28G−01 TCGA−DM−A285−01 TCGA−DM−A1D8−01 TCGA−DM−A1D7−01 TCGA−DM−A0XF−01 TCGA−DC−6683−01 TCGA−DC−6160−01 TCGA−DC−6158−01 TCGA−DC−6157−01 TCGA−DC−5869−01 TCGA−D5−7000−01 TCGA−D5−6931−01 TCGA−D5−6929−01 TCGA−D5−6926−01 TCGA−D5−6923−01 TCGA−D5−6920−01 TCGA−D5−6898−01 TCGA−D5−6529−01 TCGA−D5−5540−01 TCGA−D5−5539−01 TCGA−CM−6172−01 TCGA−CM−6168−01 TCGA−CM−5860−01 TCGA−CM−5344−01 TCGA−CM−4747−01 TCGA−CL−5918−01 TCGA−CL−5917−01 TCGA−CK−5912−01 TCGA−CK−4947−01 TCGA−CI−6624−01 TCGA−CI−6619−01 TCGA−CA−6719−01 TCGA−AZ−6606−01 TCGA−AZ−4682−01 TCGA−AZ−4616−01 TCGA−AH−6544−01 TCGA−AG−A020−01 TCGA−AG−A00H−01 TCGA−AG−3901−01 TCGA−AG−3887−01 TCGA−AG−3878−01 TCGA−AG−3731−01 TCGA−AF−6672−01 TCGA−AD−6965−01 TCGA−AD−6963−01 TCGA−AD−6899−01 TCGA−AD−6890−01 TCGA−AD−6548−01 TCGA−AA−A03J−01 TCGA−AA−A03F−01 TCGA−AA−A02Y−01 TCGA−AA−A02O−01 TCGA−AA−A01V−01 TCGA−AA−A01K−01 TCGA−AA−A01I−01 TCGA−AA−3939−01 TCGA−AA−3866−01 TCGA−AA−3852−01 TCGA−AA−3850−01 TCGA−AA−3848−01 TCGA−AA−3837−01 TCGA−AA−3818−01 TCGA−AA−3713−01 TCGA−AA−3696−01 TCGA−AA−3673−01 TCGA−AA−3489−01 TCGA−A6−6782−01 TCGA−A6−6654−01 TCGA−A6−6652−01 TCGA−A6−3808−01

MAP3K8 (TPL2) Dependent MAPK1/3 Activation FDR = 0.25%, FDR nod = 3.3%

MAP2K4

unknown CG mut

JNK Cascade ( EGF Signaling Pathway Diagram ) JNK Cascade ( PDGF Signaling Pathway ) FDR = 0.00054%, FDR nod = 0.0011%


GRM1 PTPN11

PRKCG STAT5A

PRKCH GHR

PRKCA STAT5B

PRKCI GH1

GNB3 SOCS2

JAK2 MTOR

JAK3 PTPN11

PTPRC SHC1

AKT1

STAT1 IL2RB

JAK1

PIAS3 HSP90AA1

STAT3 LCK

PRKCZ

STAT4 SOS1

STAT5B CALM3

STAT5A IL2RG

PIAS1 MYC

RAC1

PIAS2 RPS6KB1

SGMS1

STAT6 TERT

unknown CG mut

CUL1 known HCG mut

BTRC

wt

NFKB1

TNIP2

MAPK8

IKBKB

UBC

MAP2K1

JUN

UBA52

IKBKG

MAP3K8

SKP1

wt PRKCQ wt

known HCG mut PRKCB known HCG mut

wt GRB2

wt GAB2

known HCG mut NFATC2

known HCG mut EIF3A


Heterotrimeric GPCR Signaling Pathway (through Glutamate, G Alpha Q And PLC Beta) ( GPCR GroupI Metabotropic Glutamate Receptor Signaling Pathway ) FDR = 1.9e−12%, FDR nod = 0.00018% Growth Hormone Signaling Pathway(JAK2 STAT5) ( Growth Hormone Signaling(JAK2 STAT5) ) FDR = 1.9e−12%, FDR nod = 2e−05%

JAK2

BRAF

GRM5

GNAQ

ARAF

PRKCE

RAF1

SOCS3

GNB5

PRKCD PRKCZ

PIK3R1

NFKB1

IL2

JAK3

BCL2L1

JAK1

RPS6

BCL2

CALM2

FOXO3

IL2RA

MYB

RELA

SMPD1

UGCG

CHUK

MAP2K4

known HCG mut

FBXW11

wt

TCGA−AA−3877−01 TCGA−AA−3715−01 TCGA−AA−3710−01 TCGA−A6−5661−01 TCGA−EI−6506−01 TCGA−D5−6931−01 TCGA−CM−6162−01 TCGA−G4−6315−01 TCGA−D5−6540−01 TCGA−A6−6652−01 TCGA−AG−3901−01 TCGA−AF−2693−01 TCGA−AA−A022−01 TCGA−A6−2678−01 TCGA−D5−6532−01 TCGA−AZ−6599−01 TCGA−AG−A02N−01 TCGA−AA−A01T−01 TCGA−F4−6703−01 TCGA−CK−6751−01 TCGA−AA−3811−01 TCGA−AA−3561−01 TCGA−AA−3496−01 TCGA−AZ−4315−01 TCGA−AA−3947−01 TCGA−F5−6813−01 TCGA−DM−A1D6−01 TCGA−AG−3583−01 TCGA−A6−6780−01 TCGA−G4−6588−01 TCGA−AD−5900−01 TCGA−AA−3977−01 TCGA−D5−6928−01 TCGA−AG−3892−01 TCGA−AA−A03J−01 TCGA−AA−A00E−01 TCGA−AA−3558−01 TCGA−A6−6653−01 TCGA−CA−6717−01 TCGA−AA−3815−01 TCGA−AA−3525−01 TCGA−F4−6807−01 TCGA−F4−6570−01 TCGA−DM−A1HA−01 TCGA−AZ−6601−01 TCGA−AG−3611−01 TCGA−AA−3949−01 TCGA−AA−3713−01 TCGA−AA−3543−01 TCGA−AA−3516−01 TCGA−A6−2672−01 TCGA−AG−A002−01 TCGA−AA−3555−01 TCGA−AA−3510−01 TCGA−CM−5349−01 TCGA−CM−4743−01 TCGA−CK−5916−01 TCGA−G4−6304−01 TCGA−F4−6856−01 TCGA−DM−A1D8−01 TCGA−DC−6681−01 TCGA−D5−6534−01 TCGA−CM−6677−01 TCGA−CM−6161−01 TCGA−CI−6624−01 TCGA−CA−6719−01 TCGA−AZ−6607−01 TCGA−AZ−5407−01 TCGA−AA−A02K−01 TCGA−AA−A00A−01 TCGA−A6−5659−01 TCGA−AA−A010−01 TCGA−CA−6718−01 TCGA−F5−6812−01 TCGA−CM−6171−01 TCGA−CK−6746−01 TCGA−CA−6716−01 TCGA−AZ−6598−01 TCGA−AA−A00N−01 TCGA−AA−3864−01 TCGA−AA−3492−01 TCGA−A6−5666−01 TCGA−G4−6628−01 TCGA−DM−A1DA−01 TCGA−DC−5337−01 TCGA−D5−6539−01 TCGA−D5−6535−01 TCGA−CM−6172−01 TCGA−CK−4952−01 TCGA−CK−4948−01 TCGA−CK−4947−01 TCGA−AY−6196−01 TCGA−AG−A00Y−01 TCGA−AG−3727−01 TCGA−AD−6901−01 TCGA−AD−6899−01 TCGA−AD−6548−01 TCGA−AA−3986−01 TCGA−AA−3966−01 TCGA−AA−3952−01 TCGA−AA−3861−01 TCGA−AA−3845−01 TCGA−AA−3814−01 TCGA−AA−3672−01 TCGA−A6−6141−01

TCGA−D5−6928−01 TCGA−F4−6570−01 TCGA−CM−5349−01 TCGA−CM−4743−01 TCGA−CL−5918−01 TCGA−AZ−6601−01 TCGA−AZ−4323−01 TCGA−AU−3779−01 TCGA−AG−A02N−01 TCGA−AG−A002−01 TCGA−AG−3892−01 TCGA−AD−6889−01 TCGA−AA−A01Q−01 TCGA−AA−3877−01 TCGA−A6−5665−01 TCGA−CM−6172−01 TCGA−G4−6628−01 TCGA−F5−6812−01 TCGA−DM−A1DA−01 TCGA−DC−5337−01 TCGA−D5−6539−01 TCGA−D5−6535−01 TCGA−CM−6171−01 TCGA−CK−6746−01 TCGA−CK−4952−01 TCGA−CK−4948−01 TCGA−CK−4947−01 TCGA−CA−6718−01 TCGA−CA−6716−01 TCGA−AZ−6598−01 TCGA−AY−6196−01 TCGA−AG−A00Y−01 TCGA−AG−3727−01 TCGA−AD−6901−01 TCGA−AD−6899−01 TCGA−AD−6548−01 TCGA−AA−A010−01 TCGA−AA−A00N−01 TCGA−AA−3986−01 TCGA−AA−3966−01 TCGA−AA−3952−01 TCGA−AA−3864−01 TCGA−AA−3861−01 TCGA−AA−3845−01 TCGA−AA−3814−01 TCGA−AA−3672−01 TCGA−AA−3492−01 TCGA−A6−6141−01 TCGA−A6−5666−01

MAPK3 (ERK1) Activation FDR = 1.9e−12%, FDR nod = 3.6e−06% MAPK1 (ERK2) Activation FDR = 1.2e−10%, FDR nod = 0.0054%

TCGA−AF−6136−01 TCGA−AG−A032−01 TCGA−AA−A01R−01 TCGA−AZ−6603−01 TCGA−A6−6141−01 TCGA−DM−A282−01 TCGA−AG−4007−01 TCGA−AA−3864−01 TCGA−D5−6930−01 TCGA−AA−A022−01 TCGA−AA−3663−01 TCGA−A6−6780−01 TCGA−D5−6931−01 TCGA−AA−3510−01 TCGA−A6−5661−01 TCGA−EI−6506−01 TCGA−AZ−4315−01 TCGA−AA−3492−01 TCGA−CK−5913−01 TCGA−AA−3715−01 TCGA−G4−6317−01 TCGA−D5−7000−01 TCGA−CM−5349−01 TCGA−AZ−5407−01 TCGA−AG−3892−01 TCGA−AA−3994−01 TCGA−G4−6628−01 TCGA−D5−6928−01 TCGA−AD−6895−01 TCGA−G4−6586−01 TCGA−EI−6507−01 TCGA−CM−6171−01 TCGA−CM−6162−01 TCGA−CK−4952−01 TCGA−CK−4948−01 TCGA−AY−6197−01 TCGA−AA−A01P−01 TCGA−AA−3710−01 TCGA−A6−6781−01 TCGA−A6−5657−01 TCGA−AA−3555−01 TCGA−G4−6588−01 TCGA−DM−A1HA−01 TCGA−AD−6964−01 TCGA−AA−3977−01 TCGA−G4−6310−01 TCGA−G4−6307−01 TCGA−G4−6306−01 TCGA−G4−6303−01 TCGA−G4−6299−01 TCGA−DY−A1H8−01 TCGA−DY−A1DD−01 TCGA−DY−A1DC−01 TCGA−DY−A0XA−01 TCGA−DM−A28F−01 TCGA−DM−A0X9−01 TCGA−D5−6538−01 TCGA−D5−6535−01 TCGA−D5−6534−01 TCGA−CM−6676−01 TCGA−CM−6675−01 TCGA−CK−6747−01 TCGA−CK−5915−01 TCGA−CK−5914−01 TCGA−AZ−6608−01 TCGA−AZ−6601−01 TCGA−AZ−6599−01 TCGA−AH−6643−01 TCGA−AG−A036−01 TCGA−AG−4015−01 TCGA−AF−4110−01 TCGA−AF−2693−01 TCGA−AA−3712−01 TCGA−AA−3697−01 TCGA−AA−3655−01 TCGA−AG−A002−01 TCGA−CA−6717−01 TCGA−A6−5665−01 TCGA−CM−5862−01 TCGA−CK−6746−01 TCGA−CA−6718−01 TCGA−AZ−6598−01 TCGA−AY−6196−01 TCGA−AA−A010−01 TCGA−AA−3815−01 TCGA−AA−3660−01 TCGA−G4−6625−01 TCGA−G4−6309−01 TCGA−G4−6293−01 TCGA−F4−6807−01 TCGA−F4−6704−01 TCGA−F4−6569−01 TCGA−EI−6508−01 TCGA−EF−5830−01 TCGA−DM−A0XD−01 TCGA−DC−6683−01 TCGA−DC−5869−01 TCGA−D5−6929−01 TCGA−D5−6541−01 TCGA−D5−6533−01 TCGA−D5−6532−01 TCGA−CM−6170−01 TCGA−CM−6169−01 TCGA−CM−6161−01 TCGA−CM−5868−01 TCGA−CM−5860−01 TCGA−CM−4746−01 TCGA−CA−6719−01 TCGA−AZ−6607−01 TCGA−AZ−6606−01 TCGA−AZ−4616−01 TCGA−AY−5543−01 TCGA−AU−6004−01 TCGA−AF−6672−01 TCGA−AA−A02K−01 TCGA−AA−A00N−01 TCGA−AA−3984−01 TCGA−AA−3966−01 TCGA−AA−3950−01 TCGA−AA−3713−01 TCGA−AA−3662−01 TCGA−A6−5666−01 TCGA−A6−5662−01

TCGA−G4−6626−01 TCGA−AA−3870−01 TCGA−AZ−4315−01 TCGA−AD−6889−01 TCGA−AF−6136−01 TCGA−A6−5661−01 TCGA−D5−6930−01 TCGA−AA−A022−01 TCGA−AA−3663−01 TCGA−A6−6780−01 TCGA−DM−A282−01 TCGA−AG−4007−01 TCGA−AA−3864−01 TCGA−AA−3510−01 TCGA−CK−5913−01 TCGA−AA−3715−01 TCGA−G4−6317−01 TCGA−D5−7000−01 TCGA−CM−5349−01 TCGA−AZ−5407−01 TCGA−AG−3892−01 TCGA−AA−3994−01 TCGA−G4−6628−01 TCGA−D5−6928−01 TCGA−AD−6895−01 TCGA−G4−6586−01 TCGA−EI−6507−01 TCGA−CM−6171−01 TCGA−CM−6162−01 TCGA−CK−4952−01 TCGA−CK−4948−01 TCGA−AY−6197−01 TCGA−AA−A01P−01 TCGA−AA−3710−01 TCGA−A6−6781−01 TCGA−A6−5657−01 TCGA−G4−6588−01 TCGA−DM−A1HA−01 TCGA−AD−6964−01 TCGA−AA−3977−01 TCGA−AA−3555−01 TCGA−G4−6310−01 TCGA−G4−6307−01 TCGA−G4−6306−01 TCGA−G4−6303−01 TCGA−G4−6299−01 TCGA−DY−A1H8−01 TCGA−DY−A1DD−01 TCGA−DY−A1DC−01 TCGA−DY−A0XA−01 TCGA−DM−A28F−01 TCGA−DM−A0X9−01 TCGA−D5−6538−01 TCGA−D5−6535−01 TCGA−D5−6534−01 TCGA−CM−6676−01 TCGA−CM−6675−01 TCGA−CK−6747−01 TCGA−CK−5915−01 TCGA−CK−5914−01 TCGA−AZ−6608−01 TCGA−AZ−6601−01 TCGA−AZ−6599−01 TCGA−AH−6643−01 TCGA−AG−A036−01 TCGA−AG−4015−01 TCGA−AF−4110−01 TCGA−AF−2693−01 TCGA−AA−3712−01 TCGA−AA−3697−01 TCGA−AA−3655−01 TCGA−CA−6717−01 TCGA−AG−A002−01 TCGA−CM−5862−01 TCGA−CA−6718−01 TCGA−AZ−6598−01 TCGA−AY−6196−01 TCGA−AA−A010−01 TCGA−AA−3660−01 TCGA−A6−5665−01 TCGA−G4−6625−01 TCGA−G4−6309−01 TCGA−G4−6293−01 TCGA−F4−6807−01 TCGA−F4−6704−01 TCGA−F4−6569−01 TCGA−EI−6508−01 TCGA−EF−5830−01 TCGA−DM−A0XD−01 TCGA−DC−6683−01 TCGA−DC−5869−01 TCGA−D5−6929−01 TCGA−D5−6541−01 TCGA−D5−6533−01 TCGA−D5−6532−01 TCGA−CM−6170−01 TCGA−CM−6169−01 TCGA−CM−6161−01 TCGA−CM−5868−01 TCGA−CM−5860−01 TCGA−CM−4746−01 TCGA−CK−6746−01 TCGA−CA−6719−01 TCGA−AZ−6607−01 TCGA−AZ−6606−01 TCGA−AZ−4616−01 TCGA−AY−5543−01 TCGA−AU−6004−01 TCGA−AF−6672−01 TCGA−AA−A02K−01 TCGA−AA−A00N−01 TCGA−AA−3984−01 TCGA−AA−3966−01 TCGA−AA−3950−01 TCGA−AA−3815−01 TCGA−AA−3713−01 TCGA−AA−3662−01 TCGA−A6−5666−01 TCGA−A6−5662−01

NGF Signaling Pathway ( NGF Signaling Pathway ) FDR = 1.9e−12%, FDR nod = 0.23%

KRAS

unknown CG mut

MyD88 Dependent Cascade Initiated On Endosome TRAF6 Mediated Induction Of NFkB And MAP Kinases Upon TLR7/8 Or 9 Activation FDR = 0.41%, FDR nod = 0.51%

TCGA−AG−3601−01 TCGA−AG−A036−01 TCGA−CM−6161−01 TCGA−AY−6197−01 TCGA−AA−3562−01 TCGA−AA−3510−01 TCGA−AA−3984−01 TCGA−AA−3815−01 TCGA−CK−5916−01 TCGA−A6−6651−01 TCGA−AA−A010−01 TCGA−G4−6309−01 TCGA−AA−3672−01 TCGA−D5−6533−01 TCGA−CK−6746−01 TCGA−AA−3811−01 TCGA−A6−6780−01 TCGA−AA−3710−01 TCGA−AA−3518−01 TCGA−DM−A28F−01 TCGA−CM−6172−01 TCGA−AA−3856−01 TCGA−A6−6781−01 TCGA−AA−A01Q−01 TCGA−F4−6459−01 TCGA−D5−6898−01 TCGA−CK−4952−01 TCGA−CI−6621−01 TCGA−DC−6682−01 TCGA−AF−6136−01 TCGA−AA−A01V−01 TCGA−AA−3972−01 TCGA−G4−6315−01 TCGA−G4−6307−01 TCGA−G4−6304−01 TCGA−F5−6465−01 TCGA−DC−5337−01 TCGA−CM−6680−01 TCGA−CA−5797−01 TCGA−AG−A01L−01 TCGA−AG−3894−01 TCGA−AF−3913−01 TCGA−AA−A02F−01 TCGA−AA−A024−01 TCGA−AA−A00F−01 TCGA−AA−3976−01 TCGA−AA−3973−01 TCGA−AA−3850−01 TCGA−AA−3819−01 TCGA−AA−3666−01 TCGA−AA−3662−01 TCGA−AA−3549−01 TCGA−A6−2678−01 TCGA−CM−6162−01 TCGA−AG−A002−01 TCGA−AD−5900−01 TCGA−F5−6811−01 TCGA−DM−A1DA−01 TCGA−AA−3949−01 TCGA−AA−3516−01 TCGA−G4−6588−01 TCGA−F4−6570−01 TCGA−D5−6928−01 TCGA−D5−6540−01 TCGA−CM−6171−01 TCGA−CM−5864−01 TCGA−CM−5861−01 TCGA−CM−5860−01 TCGA−CM−5348−01 TCGA−CK−5913−01 TCGA−CA−6717−01 TCGA−AA−A01D−01 TCGA−AA−3950−01 TCGA−AA−3947−01 TCGA−AA−3712−01 TCGA−AA−3543−01 TCGA−AA−3525−01 TCGA−AA−3492−01 TCGA−A6−2672−01 TCGA−G4−6628−01 TCGA−G4−6321−01 TCGA−G4−6310−01 TCGA−G4−6303−01 TCGA−G4−6299−01 TCGA−F4−6460−01 TCGA−EI−6508−01 TCGA−DY−A1DD−01 TCGA−DT−5265−01 TCGA−DM−A28C−01 TCGA−DM−A0XF−01 TCGA−DC−6681−01 TCGA−DC−6158−01 TCGA−D5−6534−01 TCGA−CM−6675−01 TCGA−CM−6170−01 TCGA−CM−6169−01 TCGA−CM−5868−01 TCGA−CM−5349−01 TCGA−CK−6747−01 TCGA−CK−5914−01 TCGA−AZ−6603−01 TCGA−AY−6196−01 TCGA−AG−3578−01 TCGA−AD−6963−01 TCGA−AA−A022−01 TCGA−AA−A01P−01 TCGA−AA−A00J−01 TCGA−AA−A00D−01 TCGA−AA−3966−01 TCGA−AA−3877−01 TCGA−AA−3833−01 TCGA−AA−3821−01 TCGA−AA−3684−01 TCGA−AA−3664−01 TCGA−A6−6649−01 TCGA−A6−2676−01 TCGA−AZ−4315−01 TCGA−AA−A00N−01 TCGA−AA−3864−01 TCGA−A6−5661−01 TCGA−G4−6586−01 TCGA−D5−6930−01 TCGA−AD−6964−01 TCGA−A6−6653−01 TCGA−A6−5665−01 TCGA−G4−6625−01 TCGA−F4−6856−01 TCGA−EI−6510−01 TCGA−DM−A1D6−01 TCGA−D5−6539−01 TCGA−D5−6536−01 TCGA−D5−5538−01 TCGA−CM−6674−01 TCGA−CM−4746−01 TCGA−CM−4743−01 TCGA−CK−4947−01 TCGA−CA−6718−01 TCGA−AZ−6601−01 TCGA−AZ−6598−01 TCGA−AZ−5407−01 TCGA−AA−A01R−01 TCGA−AA−3715−01 TCGA−AA−3713−01 TCGA−AA−3663−01 TCGA−A6−5662−01 TCGA−G4−6626−01 TCGA−G4−6323−01 TCGA−F4−6703−01 TCGA−EI−6507−01 TCGA−EF−5830−01 TCGA−DM−A28H−01 TCGA−DM−A285−01 TCGA−DM−A1D9−01 TCGA−DM−A1D7−01 TCGA−DM−A1D4−01 TCGA−DM−A0XD−01 TCGA−DC−6683−01 TCGA−DC−6160−01 TCGA−D5−6932−01 TCGA−D5−6931−01 TCGA−D5−6541−01 TCGA−D5−6538−01 TCGA−D5−6535−01 TCGA−D5−6529−01 TCGA−CM−6678−01 TCGA−CM−6168−01 TCGA−CM−6166−01 TCGA−CM−5862−01 TCGA−CM−4744−01 TCGA−CK−4950−01 TCGA−CK−4948−01 TCGA−CI−6622−01 TCGA−CA−5796−01 TCGA−AZ−6606−01 TCGA−AG−3892−01 TCGA−AG−3885−01 TCGA−AG−3727−01 TCGA−AF−2691−01 TCGA−AD−6895−01 TCGA−AD−6889−01 TCGA−AA−A00K−01 TCGA−AA−A00A−01 TCGA−AA−3979−01 TCGA−AA−3977−01 TCGA−AA−3558−01 TCGA−AA−3555−01 TCGA−A6−6141−01 TCGA−A6−5666−01 TCGA−A6−5664−01 TCGA−A6−5657−01 TCGA−G5−6235−01 TCGA−G4−6306−01 TCGA−F5−6812−01 TCGA−F5−6702−01 TCGA−F5−6571−01 TCGA−F4−6855−01 TCGA−F4−6854−01 TCGA−F4−6807−01 TCGA−F4−6806−01 TCGA−F4−6805−01 TCGA−EI−6506−01 TCGA−DY−A1H8−01 TCGA−DY−A1DF−01 TCGA−DM−A28K−01 TCGA−DM−A28G−01 TCGA−DM−A282−01 TCGA−DM−A1HA−01 TCGA−DM−A1DB−01 TCGA−DM−A1D8−01 TCGA−DM−A1D0−01 TCGA−DM−A0X9−01 TCGA−DC−6155−01 TCGA−D5−7000−01 TCGA−D5−6927−01 TCGA−D5−6537−01 TCGA−D5−6532−01 TCGA−D5−5540−01 TCGA−D5−5539−01 TCGA−D5−5537−01 TCGA−CM−6164−01 TCGA−CM−6163−01 TCGA−CM−5863−01 TCGA−CM−4747−01 TCGA−CL−5917−01 TCGA−CI−6620−01 TCGA−CA−6716−01 TCGA−AZ−6608−01 TCGA−AZ−6607−01 TCGA−AZ−6605−01 TCGA−AZ−6600−01 TCGA−AZ−6599−01 TCGA−AZ−4616−01 TCGA−AY−6386−01 TCGA−AY−5543−01 TCGA−AH−6644−01 TCGA−AH−6544−01 TCGA−AG−A032−01 TCGA−AG−A02X−01 TCGA−AG−A02N−01 TCGA−AG−A025−01 TCGA−AG−A020−01 TCGA−AG−A01W−01 TCGA−AG−A015−01 TCGA−AG−A014−01 TCGA−AG−A00Y−01 TCGA−AG−A00H−01 TCGA−AG−A00C−01 TCGA−AG−A008−01 TCGA−AG−4008−01 TCGA−AG−4005−01 TCGA−AG−3999−01 TCGA−AG−3909−01 TCGA−AG−3902−01 TCGA−AG−3901−01 TCGA−AG−3896−01 TCGA−AG−3887−01 TCGA−AG−3878−01 TCGA−AG−3742−01 TCGA−AG−3731−01 TCGA−AG−3726−01 TCGA−AG−3611−01 TCGA−AG−3605−01 TCGA−AG−3602−01 TCGA−AG−3599−01 TCGA−AG−3594−01 TCGA−AG−3586−01 TCGA−AG−3583−01 TCGA−AG−3581−01 TCGA−AG−3580−01 TCGA−AG−3575−01 TCGA−AF−6672−01 TCGA−AF−6655−01 TCGA−AF−5654−01 TCGA−AF−4110−01 TCGA−AF−2692−01 TCGA−AF−2689−01 TCGA−AD−6965−01 TCGA−AD−6901−01 TCGA−AD−6548−01 TCGA−AA−A03J−01 TCGA−AA−A03F−01 TCGA−AA−A02Y−01 TCGA−AA−A02W−01 TCGA−AA−A02O−01 TCGA−AA−A029−01 TCGA−AA−A01Z−01 TCGA−AA−A01X−01 TCGA−AA−A01K−01 TCGA−AA−A01I−01 TCGA−AA−A01G−01 TCGA−AA−A01F−01 TCGA−AA−A00Q−01 TCGA−AA−3994−01 TCGA−AA−3986−01 TCGA−AA−3975−01 TCGA−AA−3941−01 TCGA−AA−3939−01 TCGA−AA−3930−01 TCGA−AA−3870−01 TCGA−AA−3854−01 TCGA−AA−3852−01 TCGA−AA−3851−01 TCGA−AA−3848−01 TCGA−AA−3844−01 TCGA−AA−3842−01 TCGA−AA−3837−01 TCGA−AA−3818−01 TCGA−AA−3814−01 TCGA−AA−3696−01 TCGA−AA−3695−01 TCGA−AA−3681−01 TCGA−AA−3680−01 TCGA−AA−3673−01 TCGA−AA−3660−01 TCGA−AA−3655−01 TCGA−AA−3561−01 TCGA−AA−3560−01 TCGA−AA−3556−01 TCGA−AA−3548−01 TCGA−AA−3532−01 TCGA−AA−3530−01 TCGA−AA−3522−01 TCGA−AA−3521−01 TCGA−AA−3520−01 TCGA−AA−3511−01 TCGA−AA−3502−01 TCGA−A6−6782−01 TCGA−A6−6654−01 TCGA−A6−6138−01 TCGA−A6−5659−01 TCGA−A6−4105−01 TCGA−A6−3808−01 TCGA−A6−2683−01

TCGA−AA−3516−01 TCGA−AU−6004−01 TCGA−AY−6196−01 TCGA−AA−3845−01 TCGA−AA−3713−01 TCGA−AG−3726−01 TCGA−A6−6780−01 TCGA−A6−3809−01 TCGA−G4−6588−01 TCGA−DM−A0X9−01 TCGA−AG−3594−01 TCGA−AA−3984−01 TCGA−AA−A01R−01 TCGA−AA−3864−01 TCGA−AA−3710−01 TCGA−F4−6856−01 TCGA−AA−3855−01 TCGA−AA−3715−01 TCGA−AA−3496−01 TCGA−D5−6928−01 TCGA−CK−4947−01 TCGA−AA−3966−01 TCGA−F4−6570−01 TCGA−DY−A1H8−01 TCGA−D5−6930−01 TCGA−CM−6674−01 TCGA−AZ−4682−01 TCGA−AG−A026−01 TCGA−AA−3837−01 TCGA−AA−3518−01 TCGA−A6−6781−01 TCGA−AA−A010−01 TCGA−AA−3663−01 TCGA−CK−5916−01 TCGA−AZ−6598−01 TCGA−AA−3672−01 TCGA−D5−6927−01 TCGA−CM−6162−01 TCGA−CA−6718−01 TCGA−AZ−4315−01 TCGA−AG−3892−01 TCGA−AA−3815−01 TCGA−AA−3697−01 TCGA−AA−3555−01 TCGA−AA−3510−01 TCGA−A6−2672−01 TCGA−AG−A002−01 TCGA−CA−6717−01 TCGA−A6−5665−01 TCGA−G4−6586−01 TCGA−DY−A0XA−01 TCGA−DT−5265−01 TCGA−D5−6932−01 TCGA−CM−5863−01 TCGA−AG−A00C−01 TCGA−AG−3882−01 TCGA−AG−3732−01 TCGA−AG−3731−01 TCGA−AF−2693−01 TCGA−AD−6964−01 TCGA−AD−5900−01 TCGA−AA−A00N−01 TCGA−AA−A004−01 TCGA−AA−3492−01

FGF7

CCNE2

FGF10

FGF16

CDK2

MAPK3 MAP2K2

IL6 MAPK1

BRAF TLR8

PLCG1 TLR7

known HCG mut

SOS2 IRAK2

PRKCD IRAK4

SHC2 MYD88

SOS1 TRAF6

FGF3

FGFR3

GRB2

KLB

FGF17

FGF23

IRS2

KL

PIK3CB

FGF1

FGF18

FGF19

FGF2

FGF20

FGF22

FGF5

FGF6

FGF8

FGF9

FRS2

PIK3R2

wt NTRK1

known HCG mut NRAS

known HCG mut PTPN11 PTPN11

wt IRS1 wt

FGFR4

CCNE1

JAK2 JAK2

unknown CG mut PIK3CA unknown CG mut

known HCG mut PTPN11 known HCG mut RB1

PI3K Cascade FDR = 1.9e−12%, FDR nod = 0.022% Phosphorylation Of Proteins Involved In G1/S Transition By Active Cyclin E:Cdk2 Complexes FDR = 1.9e−12%, FDR nod = 2.3e−11%

SHC1 wt TLR9

wt wt JAK1


JAK1

IL6ST IL6ST

IL6R

MAP2K1

TYK2

TYK2

IL6

IL6R

CDK1

unknown CG mut

known HCG mut

ARAF

ECSIT

RAF1

IRAK1

GRB2

HRAS NGF

SHC3

FGFR2

PIK3R1

PIK3C3

PIK3R4

TLR9

FGFR1

GAB1

TCGA−AA−3695−01 TCGA−DY−A1DF−01 TCGA−AA−3972−01 TCGA−CA−6716−01 TCGA−AA−3949−01 TCGA−D5−6924−01 TCGA−AA−A00D−01 TCGA−AA−3525−01 TCGA−DM−A1DA−01 TCGA−AA−3543−01 TCGA−AA−3821−01 TCGA−AA−3811−01 TCGA−AA−A01R−01 TCGA−DC−6155−01 TCGA−AA−3516−01 TCGA−AA−3502−01 TCGA−AY−4070−01 TCGA−AA−A00E−01 TCGA−AA−3845−01 TCGA−CM−6679−01 TCGA−AZ−6605−01 TCGA−AA−3854−01 TCGA−F4−6806−01 TCGA−DM−A28K−01 TCGA−CM−4744−01 TCGA−AZ−4681−01 TCGA−D5−6930−01 TCGA−D5−6928−01 TCGA−AG−A026−01 TCGA−AA−3966−01 TCGA−AA−3518−01 TCGA−AA−A00A−01 TCGA−A6−2676−01 TCGA−CA−5255−01 TCGA−AA−A01Q−01 TCGA−AA−3851−01 TCGA−DY−A1H8−01 TCGA−G4−6306−01 TCGA−DY−A1DD−01 TCGA−CM−6675−01 TCGA−CK−5915−01 TCGA−AG−A036−01 TCGA−F4−6703−01 TCGA−AA−3555−01 TCGA−AF−4110−01 TCGA−D5−6533−01 TCGA−CK−6748−01 TCGA−AD−6888−01 TCGA−AA−A022−01 TCGA−AA−A00J−01 TCGA−AA−3554−01 TCGA−AA−3984−01 TCGA−AD−6895−01 TCGA−G4−6309−01 TCGA−G4−6626−01 TCGA−CM−6167−01 TCGA−A6−6781−01 TCGA−EI−6508−01 TCGA−D5−6922−01 TCGA−AH−6549−01 TCGA−AG−A025−01 TCGA−AG−3726−01 TCGA−AA−3833−01 TCGA−AA−3664−01 TCGA−AA−3552−01 TCGA−AG−A002−01 TCGA−AD−6889−01 TCGA−DM−A28F−01 TCGA−D5−6535−01 TCGA−AG−3892−01 TCGA−AA−3710−01 TCGA−EI−6506−01 TCGA−DM−A1D6−01 TCGA−D5−6539−01 TCGA−CM−5348−01 TCGA−AZ−6600−01 TCGA−AY−6196−01 TCGA−AF−6655−01 TCGA−AD−6901−01 TCGA−A6−6142−01 TCGA−A6−6138−01 TCGA−CA−6717−01 TCGA−G4−6588−01 TCGA−AZ−4315−01 TCGA−AZ−6598−01 TCGA−AA−A010−01 TCGA−AZ−6601−01 TCGA−AY−6197−01 TCGA−AA−A00N−01 TCGA−CM−6171−01 TCGA−CA−6718−01 TCGA−A6−5665−01 TCGA−DY−A0XA−01 TCGA−D5−6540−01 TCGA−CM−5862−01 TCGA−CM−5861−01 TCGA−CK−5916−01 TCGA−AZ−6599−01 TCGA−AD−6964−01 TCGA−AA−3713−01 TCGA−AA−3712−01 TCGA−AA−3510−01 TCGA−G4−6628−01 TCGA−G4−6315−01 TCGA−CM−5860−01 TCGA−CM−4752−01 TCGA−CM−4743−01 TCGA−CK−4950−01 TCGA−AU−6004−01 TCGA−AA−3947−01 TCGA−AA−3660−01 TCGA−A6−5660−01 TCGA−G4−6625−01 TCGA−G4−6310−01 TCGA−G4−6307−01 TCGA−G4−6303−01 TCGA−G4−6299−01 TCGA−G4−6293−01 TCGA−F4−6570−01 TCGA−EI−6507−01 TCGA−DY−A1DC−01 TCGA−DM−A1DB−01 TCGA−D5−6931−01 TCGA−D5−6538−01 TCGA−D5−6534−01 TCGA−D5−6529−01 TCGA−CM−6674−01 TCGA−CM−6168−01 TCGA−CM−6162−01 TCGA−CK−6747−01 TCGA−CK−5914−01 TCGA−AZ−6608−01 TCGA−AY−6386−01 TCGA−AG−A02N−01 TCGA−AF−2693−01 TCGA−AA−3977−01 TCGA−AA−3815−01 TCGA−AA−3697−01 TCGA−AA−3492−01 TCGA−A6−6780−01 TCGA−A6−5661−01 TCGA−G5−6235−01 TCGA−G4−6586−01 TCGA−G4−6323−01 TCGA−G4−6317−01 TCGA−G4−6304−01 TCGA−F5−6813−01 TCGA−F5−6811−01 TCGA−F4−6856−01 TCGA−F4−6460−01 TCGA−F4−6459−01 TCGA−DY−A1DG−01 TCGA−DM−A28G−01 TCGA−DM−A28C−01 TCGA−DM−A1HA−01 TCGA−DM−A1D9−01 TCGA−DM−A1D7−01 TCGA−DM−A0XF−01 TCGA−DM−A0XD−01 TCGA−DM−A0X9−01 TCGA−D5−6927−01 TCGA−D5−6920−01 TCGA−D5−6898−01 TCGA−D5−6541−01 TCGA−D5−6537−01 TCGA−D5−6536−01 TCGA−D5−6532−01 TCGA−D5−5541−01 TCGA−D5−5539−01 TCGA−D5−5538−01 TCGA−CM−6680−01 TCGA−CM−6676−01 TCGA−CM−6164−01 TCGA−CM−6161−01 TCGA−CM−5349−01 TCGA−CM−4746−01 TCGA−CK−4952−01 TCGA−CK−4947−01 TCGA−CI−6624−01 TCGA−CI−6622−01 TCGA−CA−6719−01 TCGA−AZ−5403−01 TCGA−AZ−4682−01 TCGA−AY−5543−01 TCGA−AU−3779−01 TCGA−AH−6643−01 TCGA−AG−4015−01 TCGA−AF−6136−01 TCGA−AD−6965−01 TCGA−AD−6963−01 TCGA−AA−A01K−01 TCGA−AA−3950−01 TCGA−AA−3939−01 TCGA−AA−3864−01 TCGA−AA−3837−01 TCGA−AA−3715−01 TCGA−AA−3663−01 TCGA−AA−3662−01 TCGA−AA−3655−01 TCGA−AA−3511−01 TCGA−AA−3489−01 TCGA−A6−6141−01 TCGA−A6−5666−01 TCGA−A6−5662−01 TCGA−A6−5659−01 TCGA−A6−5656−01 TCGA−F5−6571−01 TCGA−F4−6855−01 TCGA−F4−6854−01 TCGA−F4−6809−01 TCGA−F4−6808−01 TCGA−F4−6807−01 TCGA−F4−6805−01 TCGA−F4−6569−01 TCGA−EF−5830−01 TCGA−DT−5265−01 TCGA−DM−A28H−01 TCGA−DM−A285−01 TCGA−DM−A1D8−01 TCGA−DC−6683−01 TCGA−DC−6682−01 TCGA−DC−6160−01 TCGA−DC−6158−01 TCGA−DC−6157−01 TCGA−DC−5869−01 TCGA−D5−7000−01 TCGA−D5−6929−01 TCGA−D5−6926−01 TCGA−D5−6923−01 TCGA−D5−5540−01 TCGA−CM−6678−01 TCGA−CM−6172−01 TCGA−CM−6169−01 TCGA−CM−6166−01 TCGA−CM−5864−01 TCGA−CM−5344−01 TCGA−CM−4747−01 TCGA−CL−5918−01 TCGA−CL−5917−01 TCGA−CK−6746−01 TCGA−CK−5912−01 TCGA−CK−4948−01 TCGA−CI−6619−01 TCGA−AZ−6606−01 TCGA−AZ−5407−01 TCGA−AZ−4616−01 TCGA−AH−6644−01 TCGA−AH−6544−01 TCGA−AG−A020−01 TCGA−AG−A00H−01 TCGA−AG−3901−01 TCGA−AG−3887−01 TCGA−AG−3878−01 TCGA−AG−3742−01 TCGA−AG−3731−01 TCGA−AF−6672−01 TCGA−AF−2687−01 TCGA−AD−6899−01 TCGA−AD−6890−01 TCGA−AD−6548−01 TCGA−AD−5900−01 TCGA−AA−A03J−01 TCGA−AA−A03F−01 TCGA−AA−A02Y−01 TCGA−AA−A02O−01 TCGA−AA−A01V−01 TCGA−AA−A01I−01 TCGA−AA−3956−01 TCGA−AA−3877−01 TCGA−AA−3866−01 TCGA−AA−3852−01 TCGA−AA−3850−01 TCGA−AA−3848−01 TCGA−AA−3818−01 TCGA−AA−3812−01 TCGA−AA−3696−01 TCGA−AA−3673−01 TCGA−AA−3496−01 TCGA−A6−6782−01 TCGA−A6−6654−01 TCGA−A6−6652−01 TCGA−A6−6649−01 TCGA−A6−5657−01 TCGA−A6−4105−01 TCGA−A6−3809−01 TCGA−A6−3808−01

TCGA−G4−6628−01 TCGA−AA−3994−01 TCGA−AA−3864−01 TCGA−AA−3492−01 TCGA−CA−6718−01 TCGA−AA−A00J−01 TCGA−AA−3984−01 TCGA−AA−3877−01 TCGA−G4−6306−01 TCGA−D5−6927−01 TCGA−CM−4743−01 TCGA−CK−4952−01 TCGA−AG−A002−01 TCGA−AA−A010−01 TCGA−G4−6625−01 TCGA−G4−6588−01 TCGA−G4−6586−01 TCGA−G4−6323−01 TCGA−G4−6321−01 TCGA−G4−6317−01 TCGA−G4−6315−01 TCGA−G4−6304−01 TCGA−G4−6299−01 TCGA−G4−6293−01 TCGA−F5−6812−01 TCGA−F5−6464−01 TCGA−F4−6806−01 TCGA−F4−6570−01 TCGA−EI−6510−01 TCGA−DY−A1H8−01 TCGA−DY−A0XA−01 TCGA−DM−A28H−01 TCGA−DM−A28G−01 TCGA−DM−A28F−01 TCGA−DM−A28C−01 TCGA−DM−A1D4−01 TCGA−DM−A0XD−01 TCGA−D5−7000−01 TCGA−D5−6932−01 TCGA−D5−6923−01 TCGA−D5−6898−01 TCGA−D5−6540−01 TCGA−D5−6539−01 TCGA−D5−6535−01 TCGA−D5−6534−01 TCGA−D5−6533−01 TCGA−D5−6532−01 TCGA−D5−5539−01 TCGA−D5−5538−01 TCGA−CM−6678−01 TCGA−CM−6676−01 TCGA−CM−6674−01 TCGA−CM−6172−01 TCGA−CM−6171−01 TCGA−CM−6169−01 TCGA−CM−6165−01 TCGA−CM−6162−01 TCGA−CM−6161−01 TCGA−CM−5860−01 TCGA−CM−5349−01 TCGA−CM−5348−01 TCGA−CM−5344−01 TCGA−CM−5341−01 TCGA−CM−4752−01 TCGA−CM−4747−01 TCGA−CK−4950−01 TCGA−CI−6620−01 TCGA−CI−6619−01 TCGA−CA−6719−01 TCGA−CA−6717−01 TCGA−CA−5797−01 TCGA−AZ−6603−01 TCGA−AZ−6601−01 TCGA−AZ−6600−01 TCGA−AZ−6599−01 TCGA−AZ−6598−01 TCGA−AZ−4323−01 TCGA−AY−6197−01 TCGA−AU−6004−01 TCGA−AU−3779−01 TCGA−AH−6549−01 TCGA−AG−3881−01 TCGA−AG−3742−01 TCGA−AF−6672−01 TCGA−AF−4110−01 TCGA−AF−2693−01 TCGA−AD−6901−01 TCGA−AD−6895−01 TCGA−AD−6889−01 TCGA−AA−3968−01 TCGA−AA−3811−01 TCGA−AA−3715−01 TCGA−AA−3713−01 TCGA−AA−3697−01 TCGA−AA−3662−01 TCGA−AA−3655−01 TCGA−AA−3510−01 TCGA−AA−3502−01 TCGA−AA−3496−01 TCGA−A6−6780−01 TCGA−A6−6652−01 TCGA−A6−6649−01 TCGA−A6−6142−01 TCGA−A6−6141−01 TCGA−A6−5666−01 TCGA−A6−5665−01 TCGA−A6−5662−01 TCGA−A6−5661−01 TCGA−A6−4105−01

PI3K Events In ERBB4 Signaling FDR = 1.9e−12%, FDR nod = 3.5e−06% PI3K Events In ERBB2 Signaling FDR = 1.9e−12%, FDR nod = 2.3e−11%

TCGA−AA−3855−01 TCGA−AA−A01D−01 TCGA−AG−A02G−01 TCGA−A6−2676−01 TCGA−CM−5348−01 TCGA−AG−4007−01 TCGA−AA−3555−01 TCGA−AA−A01R−01 TCGA−DM−A282−01 TCGA−AG−A00Y−01 TCGA−AG−3883−01 TCGA−AG−3600−01 TCGA−AA−A00E−01 TCGA−AA−3525−01 TCGA−A6−6653−01 TCGA−A6−6138−01 TCGA−AG−3892−01 TCGA−A6−6781−01 TCGA−G4−6626−01 TCGA−G4−6309−01 TCGA−EI−6508−01 TCGA−D5−6922−01 TCGA−AH−6549−01 TCGA−AG−A025−01 TCGA−AG−3726−01 TCGA−AA−3833−01 TCGA−AA−3664−01 TCGA−AA−3552−01 TCGA−AG−A002−01 TCGA−D5−6928−01 TCGA−CM−6167−01 TCGA−AD−6895−01 TCGA−AA−A01Q−01 TCGA−AA−3984−01 TCGA−AA−3966−01 TCGA−A6−2672−01 TCGA−F4−6703−01 TCGA−EI−6510−01 TCGA−DM−A1DA−01 TCGA−D5−6932−01 TCGA−CM−6170−01 TCGA−CM−6163−01 TCGA−CK−5913−01 TCGA−AY−4071−01 TCGA−AG−3599−01 TCGA−AG−3581−01 TCGA−AF−4110−01 TCGA−AA−3982−01 TCGA−AA−3875−01 TCGA−AA−3861−01 TCGA−AA−3814−01 TCGA−A6−6137−01 TCGA−CA−6717−01 TCGA−AA−A010−01 TCGA−AZ−4315−01 TCGA−AA−3510−01 TCGA−G4−6588−01 TCGA−DY−A1DG−01 TCGA−DM−A1DB−01 TCGA−D5−6927−01 TCGA−CM−6171−01 TCGA−AZ−6608−01 TCGA−AA−3947−01 TCGA−AA−3864−01 TCGA−AA−3713−01 TCGA−A6−5665−01 TCGA−A6−5661−01 TCGA−A6−5660−01 TCGA−G4−6315−01 TCGA−G4−6307−01 TCGA−G4−6304−01 TCGA−F4−6460−01 TCGA−F4−6459−01 TCGA−EI−6507−01 TCGA−DM−A285−01 TCGA−DM−A1D9−01 TCGA−DM−A1D8−01 TCGA−DM−A0XD−01 TCGA−D5−6898−01 TCGA−D5−6541−01 TCGA−D5−6540−01 TCGA−D5−6532−01 TCGA−D5−5541−01 TCGA−D5−5540−01 TCGA−D5−5538−01 TCGA−CM−6680−01 TCGA−CM−6674−01 TCGA−CM−6172−01 TCGA−CM−6164−01 TCGA−CM−6161−01 TCGA−CM−5862−01 TCGA−CM−5861−01 TCGA−CM−4752−01 TCGA−CM−4743−01 TCGA−CK−6746−01 TCGA−CK−5916−01 TCGA−CK−5914−01 TCGA−CK−4950−01 TCGA−CK−4948−01 TCGA−CA−6718−01 TCGA−AZ−6601−01 TCGA−AZ−6598−01 TCGA−AZ−4616−01 TCGA−AY−6197−01 TCGA−AY−5543−01 TCGA−AU−6004−01 TCGA−AU−3779−01 TCGA−AH−6644−01 TCGA−AH−6544−01 TCGA−AG−A02N−01 TCGA−AG−3878−01 TCGA−AF−6136−01 TCGA−AD−6899−01 TCGA−AD−5900−01 TCGA−AA−A00N−01 TCGA−AA−3977−01 TCGA−AA−3950−01 TCGA−AA−3850−01 TCGA−AA−3818−01 TCGA−AA−3815−01 TCGA−AA−3697−01 TCGA−AA−3696−01 TCGA−AA−3663−01 TCGA−AA−3662−01 TCGA−AA−3511−01 TCGA−A6−6780−01 TCGA−A6−6649−01 TCGA−A6−6141−01 TCGA−A6−5657−01 TCGA−A6−5656−01 TCGA−A6−4105−01 TCGA−G5−6235−01 TCGA−G4−6628−01 TCGA−G4−6625−01 TCGA−G4−6586−01 TCGA−G4−6323−01 TCGA−G4−6317−01 TCGA−G4−6310−01 TCGA−G4−6303−01 TCGA−G4−6299−01 TCGA−G4−6293−01 TCGA−F5−6813−01 TCGA−F5−6811−01 TCGA−F5−6571−01 TCGA−F4−6856−01 TCGA−F4−6855−01 TCGA−F4−6854−01 TCGA−F4−6809−01 TCGA−F4−6808−01 TCGA−F4−6807−01 TCGA−F4−6805−01 TCGA−F4−6570−01 TCGA−F4−6569−01 TCGA−EF−5830−01 TCGA−DY−A1DC−01 TCGA−DY−A0XA−01 TCGA−DT−5265−01 TCGA−DM−A28H−01 TCGA−DM−A28G−01 TCGA−DM−A28C−01 TCGA−DM−A1HA−01 TCGA−DM−A1D7−01 TCGA−DM−A0XF−01 TCGA−DM−A0X9−01 TCGA−DC−6683−01 TCGA−DC−6682−01 TCGA−DC−6160−01 TCGA−DC−6158−01 TCGA−DC−6157−01 TCGA−DC−5869−01 TCGA−D5−7000−01 TCGA−D5−6931−01 TCGA−D5−6929−01 TCGA−D5−6926−01 TCGA−D5−6923−01 TCGA−D5−6920−01 TCGA−D5−6538−01 TCGA−D5−6537−01 TCGA−D5−6536−01 TCGA−D5−6534−01 TCGA−D5−6529−01 TCGA−D5−5539−01 TCGA−CM−6678−01 TCGA−CM−6676−01 TCGA−CM−6169−01 TCGA−CM−6168−01 TCGA−CM−6166−01 TCGA−CM−6162−01 TCGA−CM−5864−01 TCGA−CM−5860−01 TCGA−CM−5349−01 TCGA−CM−5344−01 TCGA−CM−4747−01 TCGA−CM−4746−01 TCGA−CL−5918−01 TCGA−CL−5917−01 TCGA−CK−6747−01 TCGA−CK−5912−01 TCGA−CK−4952−01 TCGA−CK−4947−01 TCGA−CI−6624−01 TCGA−CI−6622−01 TCGA−CI−6619−01 TCGA−CA−6719−01 TCGA−AZ−6606−01 TCGA−AZ−6599−01 TCGA−AZ−5407−01 TCGA−AZ−5403−01 TCGA−AZ−4682−01 TCGA−AY−6386−01 TCGA−AH−6643−01 TCGA−AG−A020−01 TCGA−AG−A00H−01 TCGA−AG−4015−01 TCGA−AG−3901−01 TCGA−AG−3887−01 TCGA−AG−3742−01 TCGA−AG−3731−01 TCGA−AF−6672−01 TCGA−AF−2693−01 TCGA−AF−2687−01 TCGA−AD−6965−01 TCGA−AD−6964−01 TCGA−AD−6963−01 TCGA−AD−6890−01 TCGA−AD−6548−01 TCGA−AA−A03J−01 TCGA−AA−A03F−01 TCGA−AA−A02Y−01 TCGA−AA−A02O−01 TCGA−AA−A01V−01 TCGA−AA−A01K−01 TCGA−AA−A01I−01 TCGA−AA−3956−01 TCGA−AA−3939−01 TCGA−AA−3877−01 TCGA−AA−3866−01 TCGA−AA−3852−01 TCGA−AA−3848−01 TCGA−AA−3837−01 TCGA−AA−3812−01 TCGA−AA−3715−01 TCGA−AA−3712−01 TCGA−AA−3673−01 TCGA−AA−3660−01 TCGA−AA−3655−01 TCGA−AA−3496−01 TCGA−AA−3492−01 TCGA−AA−3489−01 TCGA−A6−6782−01 TCGA−A6−6654−01 TCGA−A6−6652−01 TCGA−A6−5666−01 TCGA−A6−5662−01 TCGA−A6−5659−01 TCGA−A6−3809−01 TCGA−A6−3808−01

TCGA−AA−3855−01 TCGA−AG−A02G−01 TCGA−AA−3543−01 TCGA−AA−A01D−01 TCGA−AG−4007−01 TCGA−AA−3555−01 TCGA−DM−A282−01 TCGA−AG−A00Y−01 TCGA−AG−3883−01 TCGA−AA−3525−01 TCGA−A6−6653−01 TCGA−A6−2676−01 TCGA−CM−6679−01 TCGA−AZ−6605−01 TCGA−AD−6889−01 TCGA−AA−3854−01 TCGA−A6−6138−01 TCGA−CM−6675−01 TCGA−AG−3902−01 TCGA−AG−3898−01 TCGA−AG−3732−01 TCGA−AD−6888−01 TCGA−AA−3994−01 TCGA−AA−3869−01 TCGA−F5−6464−01 TCGA−CM−5348−01 TCGA−AG−3600−01 TCGA−AA−A022−01 TCGA−AA−A00A−01 TCGA−AA−3976−01 TCGA−AA−3819−01 TCGA−AA−3695−01 TCGA−AA−3672−01 TCGA−AA−3519−01 TCGA−AG−3892−01 TCGA−AG−3726−01 TCGA−A6−6781−01 TCGA−G4−6626−01 TCGA−G4−6309−01 TCGA−EI−6508−01 TCGA−D5−6922−01 TCGA−AH−6549−01 TCGA−AG−A025−01 TCGA−AA−3833−01 TCGA−AA−3664−01 TCGA−AA−3552−01 TCGA−AA−3984−01 TCGA−DM−A1DA−01 TCGA−CM−6167−01 TCGA−AG−3599−01 TCGA−AD−6895−01 TCGA−AA−A01Q−01 TCGA−A6−2672−01 TCGA−F4−6703−01 TCGA−EI−6510−01 TCGA−D5−6932−01 TCGA−CM−6163−01 TCGA−CK−5913−01 TCGA−AY−4071−01 TCGA−AG−3581−01 TCGA−AF−4110−01 TCGA−AA−3875−01 TCGA−AA−3861−01 TCGA−AA−3814−01 TCGA−A6−6137−01 TCGA−AG−A002−01 TCGA−D5−6928−01 TCGA−AA−A01R−01 TCGA−AA−3966−01 TCGA−D5−6539−01 TCGA−CM−6170−01 TCGA−AZ−6600−01 TCGA−AA−A00R−01 TCGA−AA−A00E−01 TCGA−AA−3982−01 TCGA−AA−3502−01 TCGA−G4−6306−01 TCGA−F5−6465−01 TCGA−DY−A1DF−01 TCGA−DY−A1DD−01 TCGA−DM−A28F−01 TCGA−D5−6533−01 TCGA−CM−6677−01 TCGA−CK−6751−01 TCGA−CK−6748−01 TCGA−CK−5915−01 TCGA−AZ−6603−01 TCGA−AY−6196−01 TCGA−AD−6901−01 TCGA−AA−A02K−01 TCGA−AA−3968−01 TCGA−AA−3811−01 TCGA−AA−3542−01 TCGA−AA−3518−01 TCGA−AA−A010−01 TCGA−CA−6717−01 TCGA−G4−6588−01 TCGA−CM−6171−01 TCGA−AA−A00N−01 TCGA−AA−3864−01 TCGA−G4−6307−01 TCGA−DY−A1DG−01 TCGA−DM−A1DB−01 TCGA−D5−6927−01 TCGA−CM−5860−01 TCGA−CM−5349−01 TCGA−AZ−6601−01 TCGA−AZ−4315−01 TCGA−AY−6197−01 TCGA−AY−5543−01 TCGA−AD−6964−01 TCGA−AA−3947−01 TCGA−AA−3713−01 TCGA−AA−3510−01 TCGA−A6−5665−01 TCGA−A6−5661−01 TCGA−A6−5660−01 TCGA−G4−6315−01 TCGA−G4−6304−01 TCGA−G4−6303−01 TCGA−F4−6460−01 TCGA−EI−6507−01 TCGA−DM−A285−01 TCGA−DM−A1D8−01 TCGA−D5−6898−01 TCGA−D5−6538−01 TCGA−D5−6534−01 TCGA−D5−6532−01 TCGA−D5−5540−01 TCGA−CM−6680−01 TCGA−CM−6162−01 TCGA−CM−5862−01 TCGA−CK−5914−01 TCGA−CK−4947−01 TCGA−AZ−6608−01 TCGA−AZ−6599−01 TCGA−AZ−6598−01 TCGA−AU−6004−01 TCGA−AU−3779−01 TCGA−AH−6644−01 TCGA−AH−6544−01 TCGA−AG−A02N−01 TCGA−AF−6136−01 TCGA−AD−5900−01 TCGA−AA−3977−01 TCGA−AA−3950−01 TCGA−AA−3715−01 TCGA−AA−3712−01 TCGA−AA−3697−01 TCGA−AA−3663−01 TCGA−A6−6780−01 TCGA−A6−5657−01 TCGA−A6−4105−01 TCGA−G4−6625−01 TCGA−G4−6317−01 TCGA−G4−6299−01 TCGA−F4−6856−01 TCGA−F4−6855−01 TCGA−F4−6809−01 TCGA−F4−6808−01 TCGA−F4−6459−01 TCGA−EF−5830−01 TCGA−DY−A0XA−01 TCGA−DM−A28C−01 TCGA−DM−A1D9−01 TCGA−DM−A0XF−01 TCGA−DM−A0XD−01 TCGA−D5−6931−01 TCGA−D5−6926−01 TCGA−D5−6920−01 TCGA−D5−6541−01 TCGA−D5−6540−01 TCGA−D5−6537−01 TCGA−D5−6536−01 TCGA−D5−5541−01 TCGA−D5−5539−01 TCGA−D5−5538−01 TCGA−CM−6676−01 TCGA−CM−6674−01 TCGA−CM−6172−01 TCGA−CM−6169−01 TCGA−CM−6168−01 TCGA−CM−6166−01 TCGA−CM−6164−01 TCGA−CM−6161−01 TCGA−CM−5861−01 TCGA−CM−5344−01 TCGA−CM−4752−01 TCGA−CM−4746−01 TCGA−CM−4743−01 TCGA−CK−6746−01 TCGA−CK−5916−01 TCGA−CK−4950−01 TCGA−CK−4948−01 TCGA−CA−6718−01 TCGA−AZ−5407−01 TCGA−AZ−5403−01 TCGA−AZ−4616−01 TCGA−AG−3878−01 TCGA−AG−3742−01 TCGA−AF−2693−01 TCGA−AF−2687−01 TCGA−AD−6899−01 TCGA−AD−6890−01 TCGA−AA−3939−01 TCGA−AA−3850−01 TCGA−AA−3818−01 TCGA−AA−3815−01 TCGA−AA−3696−01 TCGA−AA−3662−01 TCGA−AA−3660−01 TCGA−AA−3511−01 TCGA−AA−3492−01 TCGA−A6−6649−01 TCGA−A6−6141−01 TCGA−A6−5656−01 TCGA−A6−3809−01 TCGA−G5−6235−01 TCGA−G4−6628−01 TCGA−G4−6586−01 TCGA−G4−6323−01 TCGA−G4−6310−01 TCGA−G4−6293−01 TCGA−F5−6813−01 TCGA−F5−6811−01 TCGA−F5−6571−01 TCGA−F4−6854−01 TCGA−F4−6807−01 TCGA−F4−6805−01 TCGA−F4−6570−01 TCGA−F4−6569−01 TCGA−DY−A1DC−01 TCGA−DT−5265−01 TCGA−DM−A28H−01 TCGA−DM−A28G−01 TCGA−DM−A1HA−01 TCGA−DM−A1D7−01 TCGA−DM−A0X9−01 TCGA−DC−6683−01 TCGA−DC−6682−01 TCGA−DC−6160−01 TCGA−DC−6158−01 TCGA−DC−6157−01 TCGA−DC−5869−01 TCGA−D5−7000−01 TCGA−D5−6929−01 TCGA−D5−6923−01 TCGA−D5−6529−01 TCGA−CM−6678−01 TCGA−CM−5864−01 TCGA−CM−4747−01 TCGA−CL−5918−01 TCGA−CL−5917−01 TCGA−CK−6747−01 TCGA−CK−5912−01 TCGA−CK−4952−01 TCGA−CI−6624−01 TCGA−CI−6622−01 TCGA−CI−6619−01 TCGA−CA−6719−01 TCGA−AZ−6606−01 TCGA−AZ−4682−01 TCGA−AY−6386−01 TCGA−AH−6643−01 TCGA−AG−A020−01 TCGA−AG−A00H−01 TCGA−AG−4015−01 TCGA−AG−3901−01 TCGA−AG−3887−01 TCGA−AG−3731−01 TCGA−AF−6672−01 TCGA−AD−6965−01 TCGA−AD−6963−01 TCGA−AD−6548−01 TCGA−AA−A03J−01 TCGA−AA−A03F−01 TCGA−AA−A02Y−01 TCGA−AA−A02O−01 TCGA−AA−A01V−01 TCGA−AA−A01K−01 TCGA−AA−A01I−01 TCGA−AA−3956−01 TCGA−AA−3877−01 TCGA−AA−3866−01 TCGA−AA−3852−01 TCGA−AA−3848−01 TCGA−AA−3837−01 TCGA−AA−3812−01 TCGA−AA−3673−01 TCGA−AA−3655−01 TCGA−AA−3496−01 TCGA−AA−3489−01 TCGA−A6−6782−01 TCGA−A6−6654−01 TCGA−A6−6652−01 TCGA−A6−5666−01 TCGA−A6−5662−01 TCGA−A6−5659−01 TCGA−A6−3808−01

HRAS

POLR2K

FRS2

POLR2D

FGF8

GTF2F2

FGF7

FGF1

FGF5

POLR2I

FGF3

POLR2E

FGF22

POLR2C

FGF2

NCBP2

SOS1 NCBP1

FGF18

POLR2H

NRAS POLR2A

FGF10

POLR2F

KRAS FGFR2

FGF17

GTF2F1

NRG1 ERBB2

BTC GRB2

HBEGF EREG

known HCG mut KRAS

PRKCQ ARAF

ARAF SOS2

RAF1 SOS1


FGF1

FGF16

FGF20

FGF23

FGF6

FGF9

GRB2

wt PLCG1 wt FGF2

TCGA−AA−3562−01 TCGA−AA−3510−01 TCGA−CM−6161−01 TCGA−A6−6781−01 TCGA−CM−6172−01 TCGA−AG−A011−01 TCGA−AA−3984−01 TCGA−CK−5916−01 TCGA−AA−3518−01 TCGA−A6−6651−01 TCGA−F4−6704−01 TCGA−CM−5344−01 TCGA−AA−A00E−01 TCGA−A6−6652−01 TCGA−G4−6307−01 TCGA−AA−A01V−01 TCGA−G4−6315−01 TCGA−G4−6304−01 TCGA−F5−6465−01 TCGA−DC−6682−01 TCGA−DC−5337−01 TCGA−CM−6680−01 TCGA−CA−5797−01 TCGA−AG−A01L−01 TCGA−AG−3894−01 TCGA−AF−6136−01 TCGA−AF−3913−01 TCGA−AA−A02F−01 TCGA−AA−A024−01 TCGA−AA−A00F−01 TCGA−AA−3976−01 TCGA−AA−3973−01 TCGA−AA−3972−01 TCGA−AA−3850−01 TCGA−AA−3819−01 TCGA−AA−3666−01 TCGA−AA−3662−01 TCGA−AA−3549−01 TCGA−A6−2678−01 TCGA−CM−6162−01 TCGA−CA−6717−01 TCGA−AG−A002−01 TCGA−DM−A1DA−01 TCGA−CM−5864−01 TCGA−AA−3877−01 TCGA−AA−3821−01 TCGA−AA−3516−01 TCGA−AA−3492−01 TCGA−G4−6628−01 TCGA−G4−6588−01 TCGA−G4−6321−01 TCGA−G4−6310−01 TCGA−G4−6303−01 TCGA−G4−6299−01 TCGA−F5−6811−01 TCGA−F4−6570−01 TCGA−F4−6460−01 TCGA−EI−6508−01 TCGA−DY−A1DD−01 TCGA−DT−5265−01 TCGA−DM−A28C−01 TCGA−DM−A0XF−01 TCGA−DC−6681−01 TCGA−DC−6158−01 TCGA−D5−6928−01 TCGA−D5−6540−01 TCGA−D5−6534−01 TCGA−CM−6675−01 TCGA−CM−6171−01 TCGA−CM−6170−01 TCGA−CM−6169−01 TCGA−CM−5868−01 TCGA−CM−5861−01 TCGA−CM−5860−01 TCGA−CM−5349−01 TCGA−CM−5348−01 TCGA−CK−6747−01 TCGA−CK−5914−01 TCGA−CK−5913−01 TCGA−AZ−6603−01 TCGA−AY−6196−01 TCGA−AG−3578−01 TCGA−AD−6963−01 TCGA−AD−5900−01 TCGA−AA−A022−01 TCGA−AA−A01P−01 TCGA−AA−A01D−01 TCGA−AA−A00J−01 TCGA−AA−A00D−01 TCGA−AA−3966−01 TCGA−AA−3950−01 TCGA−AA−3949−01 TCGA−AA−3947−01 TCGA−AA−3833−01 TCGA−AA−3712−01 TCGA−AA−3684−01 TCGA−AA−3664−01 TCGA−AA−3543−01 TCGA−AA−3525−01 TCGA−A6−6649−01 TCGA−A6−2676−01 TCGA−A6−2672−01 TCGA−CM−6674−01 TCGA−AA−A00N−01 TCGA−G4−6586−01 TCGA−EI−6510−01 TCGA−DM−A28H−01 TCGA−D5−6930−01 TCGA−D5−6539−01 TCGA−D5−5538−01 TCGA−CA−6718−01 TCGA−AZ−5407−01 TCGA−AZ−4315−01 TCGA−AA−3864−01 TCGA−AA−3715−01 TCGA−AA−3713−01 TCGA−G4−6626−01 TCGA−G4−6625−01 TCGA−G4−6323−01 TCGA−F4−6856−01 TCGA−EF−5830−01 TCGA−DM−A28G−01 TCGA−DM−A285−01 TCGA−DM−A1HA−01 TCGA−DM−A1D9−01 TCGA−DM−A1D7−01 TCGA−DM−A1D6−01 TCGA−DM−A1D4−01 TCGA−DM−A0XD−01 TCGA−DC−6683−01 TCGA−DC−6160−01 TCGA−D5−6932−01 TCGA−D5−6536−01 TCGA−D5−6535−01 TCGA−D5−6529−01 TCGA−CM−6678−01 TCGA−CM−6168−01 TCGA−CM−4746−01 TCGA−CM−4744−01 TCGA−CM−4743−01 TCGA−CK−4950−01 TCGA−CK−4947−01 TCGA−CA−5796−01 TCGA−AZ−6606−01 TCGA−AZ−6601−01 TCGA−AZ−6600−01 TCGA−AZ−6598−01 TCGA−AZ−4616−01 TCGA−AY−5543−01 TCGA−AG−A00C−01 TCGA−AG−3892−01 TCGA−AG−3885−01 TCGA−AG−3727−01 TCGA−AF−2691−01 TCGA−AD−6964−01 TCGA−AD−6895−01 TCGA−AD−6889−01 TCGA−AA−3977−01 TCGA−AA−3663−01 TCGA−AA−3558−01 TCGA−A6−6653−01 TCGA−A6−5666−01 TCGA−A6−5665−01 TCGA−A6−5664−01 TCGA−A6−5661−01 TCGA−A6−5657−01 TCGA−G5−6235−01 TCGA−G4−6306−01 TCGA−F5−6812−01 TCGA−F5−6702−01 TCGA−F5−6571−01 TCGA−F4−6855−01 TCGA−F4−6854−01 TCGA−F4−6807−01 TCGA−F4−6806−01 TCGA−F4−6805−01 TCGA−F4−6703−01 TCGA−EI−6507−01 TCGA−EI−6506−01 TCGA−DY−A1H8−01 TCGA−DY−A1DF−01 TCGA−DM−A28K−01 TCGA−DM−A282−01 TCGA−DM−A1DB−01 TCGA−DM−A1D8−01 TCGA−DM−A1D0−01 TCGA−DM−A0X9−01 TCGA−DC−6155−01 TCGA−D5−7000−01 TCGA−D5−6931−01 TCGA−D5−6927−01 TCGA−D5−6541−01 TCGA−D5−6538−01 TCGA−D5−6537−01 TCGA−D5−6532−01 TCGA−D5−5540−01 TCGA−D5−5539−01 TCGA−D5−5537−01 TCGA−CM−6166−01 TCGA−CM−6164−01 TCGA−CM−6163−01 TCGA−CM−5863−01 TCGA−CM−5862−01 TCGA−CM−4747−01 TCGA−CL−5917−01 TCGA−CK−4948−01 TCGA−CI−6622−01 TCGA−CI−6620−01 TCGA−CA−6716−01 TCGA−AZ−6608−01 TCGA−AZ−6607−01 TCGA−AZ−6605−01 TCGA−AZ−6599−01 TCGA−AY−6386−01 TCGA−AH−6644−01 TCGA−AH−6544−01 TCGA−AG−A032−01 TCGA−AG−A02X−01 TCGA−AG−A02N−01 TCGA−AG−A025−01 TCGA−AG−A020−01 TCGA−AG−A01W−01 TCGA−AG−A015−01 TCGA−AG−A014−01 TCGA−AG−A00Y−01 TCGA−AG−A00H−01 TCGA−AG−A008−01 TCGA−AG−4008−01 TCGA−AG−4005−01 TCGA−AG−3999−01 TCGA−AG−3909−01 TCGA−AG−3902−01 TCGA−AG−3901−01 TCGA−AG−3896−01 TCGA−AG−3887−01 TCGA−AG−3878−01 TCGA−AG−3742−01 TCGA−AG−3731−01 TCGA−AG−3726−01 TCGA−AG−3611−01 TCGA−AG−3605−01 TCGA−AG−3602−01 TCGA−AG−3599−01 TCGA−AG−3594−01 TCGA−AG−3586−01 TCGA−AG−3583−01 TCGA−AG−3581−01 TCGA−AG−3580−01 TCGA−AG−3575−01 TCGA−AF−6672−01 TCGA−AF−6655−01 TCGA−AF−5654−01 TCGA−AF−4110−01 TCGA−AF−2692−01 TCGA−AF−2689−01 TCGA−AD−6965−01 TCGA−AD−6901−01 TCGA−AD−6548−01 TCGA−AA−A03J−01 TCGA−AA−A03F−01 TCGA−AA−A02Y−01 TCGA−AA−A02W−01 TCGA−AA−A02O−01 TCGA−AA−A029−01 TCGA−AA−A01Z−01 TCGA−AA−A01X−01 TCGA−AA−A01R−01 TCGA−AA−A01K−01 TCGA−AA−A01I−01 TCGA−AA−A01G−01 TCGA−AA−A01F−01 TCGA−AA−A00Q−01 TCGA−AA−A00K−01 TCGA−AA−A00A−01 TCGA−AA−3994−01 TCGA−AA−3986−01 TCGA−AA−3979−01 TCGA−AA−3975−01 TCGA−AA−3941−01 TCGA−AA−3939−01 TCGA−AA−3930−01 TCGA−AA−3870−01 TCGA−AA−3854−01 TCGA−AA−3852−01 TCGA−AA−3851−01 TCGA−AA−3848−01 TCGA−AA−3844−01 TCGA−AA−3842−01 TCGA−AA−3837−01 TCGA−AA−3818−01 TCGA−AA−3814−01 TCGA−AA−3696−01 TCGA−AA−3695−01 TCGA−AA−3681−01 TCGA−AA−3680−01 TCGA−AA−3673−01 TCGA−AA−3660−01 TCGA−AA−3655−01 TCGA−AA−3561−01 TCGA−AA−3560−01 TCGA−AA−3556−01 TCGA−AA−3555−01 TCGA−AA−3548−01 TCGA−AA−3532−01 TCGA−AA−3530−01 TCGA−AA−3522−01 TCGA−AA−3521−01 TCGA−AA−3520−01 TCGA−AA−3511−01 TCGA−AA−3502−01 TCGA−A6−6782−01 TCGA−A6−6654−01 TCGA−A6−6141−01 TCGA−A6−6138−01 TCGA−A6−5662−01 TCGA−A6−5659−01 TCGA−A6−4105−01 TCGA−A6−3808−01 TCGA−A6−2683−01

TCGA−AG−3601−01 TCGA−AY−6197−01 TCGA−AA−3562−01 TCGA−AA−3510−01 TCGA−CM−6161−01 TCGA−A6−6781−01 TCGA−AA−A010−01 TCGA−G4−6309−01 TCGA−AA−3672−01 TCGA−CK−5916−01 TCGA−AA−3518−01 TCGA−A6−6651−01 TCGA−DC−6682−01 TCGA−AF−6136−01 TCGA−AA−A01V−01 TCGA−G4−6315−01 TCGA−G4−6307−01 TCGA−G4−6304−01 TCGA−F5−6465−01 TCGA−DC−5337−01 TCGA−CM−6680−01 TCGA−CA−5797−01 TCGA−AG−A01L−01 TCGA−AG−3894−01 TCGA−AF−3913−01 TCGA−AA−A02F−01 TCGA−AA−A024−01 TCGA−AA−A00F−01 TCGA−AA−3976−01 TCGA−AA−3973−01 TCGA−AA−3972−01 TCGA−AA−3850−01 TCGA−AA−3819−01 TCGA−AA−3666−01 TCGA−AA−3662−01 TCGA−AA−3549−01 TCGA−A6−2678−01 TCGA−AG−A002−01 TCGA−DM−A1DA−01 TCGA−CM−6162−01 TCGA−AA−3949−01 TCGA−AA−3516−01 TCGA−G4−6588−01 TCGA−F5−6811−01 TCGA−D5−6540−01 TCGA−CM−5864−01 TCGA−CA−6717−01 TCGA−AA−A01D−01 TCGA−AA−3947−01 TCGA−AA−3712−01 TCGA−AA−3543−01 TCGA−AA−3492−01 TCGA−A6−2672−01 TCGA−G4−6628−01 TCGA−G4−6321−01 TCGA−G4−6310−01 TCGA−G4−6303−01 TCGA−G4−6299−01 TCGA−F4−6570−01 TCGA−F4−6460−01 TCGA−EI−6508−01 TCGA−DY−A1DD−01 TCGA−DT−5265−01 TCGA−DM−A28C−01 TCGA−DM−A0XF−01 TCGA−DC−6681−01 TCGA−DC−6158−01 TCGA−D5−6928−01 TCGA−D5−6534−01 TCGA−CM−6675−01 TCGA−CM−6171−01 TCGA−CM−6170−01 TCGA−CM−6169−01 TCGA−CM−5868−01 TCGA−CM−5861−01 TCGA−CM−5860−01 TCGA−CM−5349−01 TCGA−CM−5348−01 TCGA−CK−6747−01 TCGA−CK−5914−01 TCGA−CK−5913−01 TCGA−AZ−6603−01 TCGA−AY−6196−01 TCGA−AG−3578−01 TCGA−AD−6963−01 TCGA−AD−5900−01 TCGA−AA−A022−01 TCGA−AA−A01P−01 TCGA−AA−A00J−01 TCGA−AA−A00D−01 TCGA−AA−3966−01 TCGA−AA−3950−01 TCGA−AA−3877−01 TCGA−AA−3833−01 TCGA−AA−3821−01 TCGA−AA−3684−01 TCGA−AA−3664−01 TCGA−AA−3525−01 TCGA−A6−6649−01 TCGA−A6−2676−01 TCGA−AA−A00N−01 TCGA−AA−3864−01 TCGA−G4−6625−01 TCGA−G4−6586−01 TCGA−EI−6510−01 TCGA−D5−6539−01 TCGA−D5−6536−01 TCGA−D5−5538−01 TCGA−CM−6674−01 TCGA−AZ−5407−01 TCGA−AZ−4315−01 TCGA−AD−6964−01 TCGA−AA−3715−01 TCGA−AA−3713−01 TCGA−A6−6653−01 TCGA−A6−5665−01 TCGA−A6−5661−01 TCGA−G4−6626−01 TCGA−G4−6323−01 TCGA−F4−6856−01 TCGA−F4−6703−01 TCGA−EF−5830−01 TCGA−DM−A28H−01 TCGA−DM−A285−01 TCGA−DM−A1D9−01 TCGA−DM−A1D7−01 TCGA−DM−A1D6−01 TCGA−DM−A1D4−01 TCGA−DM−A0XD−01 TCGA−DC−6683−01 TCGA−DC−6160−01 TCGA−D5−6932−01 TCGA−D5−6930−01 TCGA−D5−6538−01 TCGA−D5−6535−01 TCGA−D5−6529−01 TCGA−CM−6678−01 TCGA−CM−6168−01 TCGA−CM−4746−01 TCGA−CM−4744−01 TCGA−CM−4743−01 TCGA−CK−4950−01 TCGA−CK−4948−01 TCGA−CK−4947−01 TCGA−CI−6622−01 TCGA−CA−6718−01 TCGA−CA−5796−01 TCGA−AZ−6606−01 TCGA−AZ−6601−01 TCGA−AZ−6598−01 TCGA−AG−3892−01 TCGA−AG−3885−01 TCGA−AF−2691−01 TCGA−AD−6895−01 TCGA−AD−6889−01 TCGA−AA−A00A−01 TCGA−AA−3977−01 TCGA−AA−3663−01 TCGA−AA−3558−01 TCGA−AA−3555−01 TCGA−A6−6141−01 TCGA−A6−5666−01 TCGA−A6−5664−01 TCGA−A6−5657−01 TCGA−G5−6235−01 TCGA−G4−6306−01 TCGA−F5−6812−01 TCGA−F5−6702−01 TCGA−F5−6571−01 TCGA−F4−6855−01 TCGA−F4−6854−01 TCGA−F4−6807−01 TCGA−F4−6806−01 TCGA−F4−6805−01 TCGA−EI−6507−01 TCGA−EI−6506−01 TCGA−DY−A1H8−01 TCGA−DY−A1DF−01 TCGA−DM−A28K−01 TCGA−DM−A28G−01 TCGA−DM−A282−01 TCGA−DM−A1HA−01 TCGA−DM−A1DB−01 TCGA−DM−A1D8−01 TCGA−DM−A1D0−01 TCGA−DM−A0X9−01 TCGA−DC−6155−01 TCGA−D5−7000−01 TCGA−D5−6931−01 TCGA−D5−6927−01 TCGA−D5−6541−01 TCGA−D5−6537−01 TCGA−D5−6532−01 TCGA−D5−5540−01 TCGA−D5−5539−01 TCGA−D5−5537−01 TCGA−CM−6166−01 TCGA−CM−6164−01 TCGA−CM−6163−01 TCGA−CM−5863−01 TCGA−CM−5862−01 TCGA−CM−4747−01 TCGA−CL−5917−01 TCGA−CI−6620−01 TCGA−CA−6716−01 TCGA−AZ−6608−01 TCGA−AZ−6607−01 TCGA−AZ−6605−01 TCGA−AZ−6600−01 TCGA−AZ−6599−01 TCGA−AZ−4616−01 TCGA−AY−6386−01 TCGA−AY−5543−01 TCGA−AH−6644−01 TCGA−AH−6544−01 TCGA−AG−A032−01 TCGA−AG−A02X−01 TCGA−AG−A02N−01 TCGA−AG−A025−01 TCGA−AG−A020−01 TCGA−AG−A01W−01 TCGA−AG−A015−01 TCGA−AG−A014−01 TCGA−AG−A00Y−01 TCGA−AG−A00H−01 TCGA−AG−A00C−01 TCGA−AG−A008−01 TCGA−AG−4008−01 TCGA−AG−4005−01 TCGA−AG−3999−01 TCGA−AG−3909−01 TCGA−AG−3902−01 TCGA−AG−3901−01 TCGA−AG−3896−01 TCGA−AG−3887−01 TCGA−AG−3878−01 TCGA−AG−3742−01 TCGA−AG−3731−01 TCGA−AG−3727−01 TCGA−AG−3726−01 TCGA−AG−3611−01 TCGA−AG−3605−01 TCGA−AG−3602−01 TCGA−AG−3599−01 TCGA−AG−3594−01 TCGA−AG−3586−01 TCGA−AG−3583−01 TCGA−AG−3581−01 TCGA−AG−3580−01 TCGA−AG−3575−01 TCGA−AF−6672−01 TCGA−AF−6655−01 TCGA−AF−5654−01 TCGA−AF−4110−01 TCGA−AF−2692−01 TCGA−AF−2689−01 TCGA−AD−6965−01 TCGA−AD−6901−01 TCGA−AD−6548−01 TCGA−AA−A03J−01 TCGA−AA−A03F−01 TCGA−AA−A02Y−01 TCGA−AA−A02W−01 TCGA−AA−A02O−01 TCGA−AA−A029−01 TCGA−AA−A01Z−01 TCGA−AA−A01X−01 TCGA−AA−A01R−01 TCGA−AA−A01K−01 TCGA−AA−A01I−01 TCGA−AA−A01G−01 TCGA−AA−A01F−01 TCGA−AA−A00Q−01 TCGA−AA−A00K−01 TCGA−AA−3994−01 TCGA−AA−3986−01 TCGA−AA−3979−01 TCGA−AA−3975−01 TCGA−AA−3941−01 TCGA−AA−3939−01 TCGA−AA−3930−01 TCGA−AA−3870−01 TCGA−AA−3854−01 TCGA−AA−3852−01 TCGA−AA−3851−01 TCGA−AA−3848−01 TCGA−AA−3844−01 TCGA−AA−3842−01 TCGA−AA−3837−01 TCGA−AA−3818−01 TCGA−AA−3814−01 TCGA−AA−3696−01 TCGA−AA−3695−01 TCGA−AA−3681−01 TCGA−AA−3680−01 TCGA−AA−3673−01 TCGA−AA−3660−01 TCGA−AA−3655−01 TCGA−AA−3561−01 TCGA−AA−3560−01 TCGA−AA−3556−01 TCGA−AA−3548−01 TCGA−AA−3532−01 TCGA−AA−3530−01 TCGA−AA−3522−01 TCGA−AA−3521−01 TCGA−AA−3520−01 TCGA−AA−3511−01 TCGA−AA−3502−01 TCGA−A6−6782−01 TCGA−A6−6654−01 TCGA−A6−6138−01 TCGA−A6−5662−01 TCGA−A6−5659−01 TCGA−A6−4105−01 TCGA−A6−3808−01 TCGA−A6−2683−01

Signaling By FGFR2 In Disease FDR = 1.9e−12%, FDR nod = 0.72% Signaling By FGFR2 IIIa TM FDR = 4.8%, FDR nod = 4.8%

known HCG mut PIK3R1 known HCG mut

FGFR2 POLR2B

known HCG mut BRAF

Raf Activation Signaling (through RasGRP) ( CD4 T Cell Receptor Signaling (ERK Cascade) ) Raf Activation Signaling (through RasGRP) ( CD4 T Cell Receptor Signaling ) FDR = 1.9e−12%, FDR nod = 0.2%

KRAS

unknown CG mut

Raf Activation Signaling (through Grb2 And Sos) ( B Cell Receptor Signaling ) Raf Activation Signaling (through Grb2 And Sos) ( CD4 T Cell Receptor Signaling (ERK Cascade) ) Raf Activation Signaling (through Grb2 And Sos) ( CD4 T Cell Receptor Signaling ) Raf Activation Signaling (through Grb2 And Sos) ( JAK STAT Pathway And Regulation Pathway Diagram ) FDR = 1.9e−12%, FDR nod = 2.5%

wt wt ERBB3

known HCG mut ERBB4 known HCG mut ERBB4


PIK3CA EGFR

PIK3R1

PIK3R1

GAB1

NRG1

NRG3

NRG3 BTC

NRG2

NRG2 EGF

EREG

HBEGF NRG4

NRG4

unknown CG mut

BRAF

NRAS

NRAS

wt

wt

HRAS

RAF1

RASGRP1

GRB2

HRAS

PIK3CA

GAB1

TCGA−AA−3543−01 TCGA−D5−6924−01 TCGA−CI−6621−01 TCGA−AA−A01Q−01 TCGA−CM−6679−01 TCGA−A6−2676−01 TCGA−AA−3949−01 TCGA−AA−3516−01 TCGA−AG−3601−01 TCGA−AA−3710−01 TCGA−DM−A28F−01 TCGA−CM−5348−01 TCGA−AY−6196−01 TCGA−A6−6142−01 TCGA−AG−A002−01 TCGA−AA−3984−01 TCGA−G4−6309−01 TCGA−A6−6781−01 TCGA−EI−6508−01 TCGA−D5−6922−01 TCGA−CM−6167−01 TCGA−AH−6549−01 TCGA−AA−3833−01 TCGA−AA−3664−01 TCGA−AA−3552−01 TCGA−DM−A1DA−01 TCGA−AA−3972−01 TCGA−F5−6465−01 TCGA−DC−5337−01 TCGA−CA−5797−01 TCGA−AG−A01L−01 TCGA−AG−3894−01 TCGA−AF−3913−01 TCGA−AA−A02F−01 TCGA−AA−A024−01 TCGA−AA−A00F−01 TCGA−AA−3976−01 TCGA−AA−3973−01 TCGA−AA−3819−01 TCGA−AA−3666−01 TCGA−AA−3549−01 TCGA−A6−2678−01 TCGA−CM−6171−01 TCGA−CA−6717−01 TCGA−AA−A010−01 TCGA−G4−6588−01 TCGA−F5−6811−01 TCGA−CM−5861−01 TCGA−CK−5916−01 TCGA−AY−6197−01 TCGA−G4−6628−01 TCGA−G4−6315−01 TCGA−G4−6307−01 TCGA−G4−6304−01 TCGA−DC−6682−01 TCGA−D5−6898−01 TCGA−D5−6540−01 TCGA−CM−6162−01 TCGA−CM−6161−01 TCGA−CM−4752−01 TCGA−CK−4952−01 TCGA−AU−6004−01 TCGA−AF−6136−01 TCGA−AA−3947−01 TCGA−AA−3662−01 TCGA−AA−3510−01 TCGA−A6−6780−01 TCGA−A6−5660−01 TCGA−G4−6317−01 TCGA−G4−6293−01 TCGA−F5−6813−01 TCGA−F4−6570−01 TCGA−F4−6460−01 TCGA−F4−6459−01 TCGA−DY−A1DG−01 TCGA−DY−A1DC−01 TCGA−DY−A0XA−01 TCGA−DM−A28C−01 TCGA−DM−A0XF−01 TCGA−D5−6920−01 TCGA−D5−5541−01 TCGA−CM−6680−01 TCGA−CM−5864−01 TCGA−CM−5860−01 TCGA−CM−5349−01 TCGA−CK−5914−01 TCGA−AU−3779−01 TCGA−AF−2693−01 TCGA−AA−A01V−01 TCGA−AA−3850−01 TCGA−AA−3712−01 TCGA−AA−3697−01 TCGA−AA−3492−01 TCGA−AA−3489−01 TCGA−A6−5656−01 TCGA−G4−6310−01 TCGA−G4−6303−01 TCGA−G4−6299−01 TCGA−F4−6809−01 TCGA−F4−6808−01 TCGA−F4−6569−01 TCGA−DT−5265−01 TCGA−DC−6158−01 TCGA−DC−6157−01 TCGA−DC−5869−01 TCGA−D5−6929−01 TCGA−D5−6926−01 TCGA−D5−6923−01 TCGA−D5−6534−01 TCGA−CM−6676−01 TCGA−CM−6172−01 TCGA−CM−6169−01 TCGA−CM−5344−01 TCGA−CL−5918−01 TCGA−CK−6747−01 TCGA−CK−6746−01 TCGA−CK−5912−01 TCGA−CI−6624−01 TCGA−CI−6619−01 TCGA−CA−6719−01 TCGA−AZ−5403−01 TCGA−AZ−4682−01 TCGA−AH−6643−01 TCGA−AG−4015−01 TCGA−AF−2687−01 TCGA−AD−6963−01 TCGA−AD−6899−01 TCGA−AD−6890−01 TCGA−AD−5900−01 TCGA−AA−3956−01 TCGA−AA−3950−01 TCGA−AA−3877−01 TCGA−AA−3866−01 TCGA−AA−3815−01 TCGA−AA−3812−01 TCGA−AA−3496−01 TCGA−A6−6652−01 TCGA−A6−6649−01 TCGA−A6−3809−01 TCGA−AZ−4315−01 TCGA−AA−A00N−01 TCGA−CM−4743−01 TCGA−AZ−6601−01 TCGA−AD−6895−01 TCGA−AA−3713−01 TCGA−G4−6625−01 TCGA−DM−A1DB−01 TCGA−DM−A1D9−01 TCGA−D5−6529−01 TCGA−D5−5538−01 TCGA−CM−5862−01 TCGA−CK−4950−01 TCGA−CI−6622−01 TCGA−CA−6718−01 TCGA−AZ−6598−01 TCGA−AG−3892−01 TCGA−AD−6964−01 TCGA−AA−3977−01 TCGA−AA−3864−01 TCGA−AA−3663−01 TCGA−A6−5666−01 TCGA−A6−5665−01 TCGA−A6−5662−01 TCGA−G5−6235−01 TCGA−G4−6586−01 TCGA−G4−6323−01 TCGA−F4−6856−01 TCGA−F4−6703−01 TCGA−EI−6507−01 TCGA−DM−A28G−01 TCGA−DM−A0XD−01 TCGA−D5−6927−01 TCGA−D5−6539−01 TCGA−D5−6538−01 TCGA−D5−6537−01 TCGA−D5−6536−01 TCGA−D5−6532−01 TCGA−D5−5539−01 TCGA−CM−6674−01 TCGA−CM−6168−01 TCGA−CM−6166−01 TCGA−CM−6164−01 TCGA−CK−4948−01 TCGA−AZ−6608−01 TCGA−AZ−6599−01 TCGA−AY−6386−01 TCGA−AY−5543−01 TCGA−AG−A02N−01 TCGA−AD−6889−01 TCGA−AA−A01R−01 TCGA−AA−A01K−01 TCGA−AA−3715−01 TCGA−AA−3660−01 TCGA−AA−3511−01 TCGA−A6−6141−01 TCGA−A6−5661−01 TCGA−G4−6626−01 TCGA−F5−6571−01 TCGA−F4−6855−01 TCGA−F4−6854−01 TCGA−F4−6807−01 TCGA−F4−6805−01 TCGA−EI−6510−01 TCGA−EI−6506−01 TCGA−EF−5830−01 TCGA−DM−A28H−01 TCGA−DM−A285−01 TCGA−DM−A1HA−01 TCGA−DM−A1D8−01 TCGA−DM−A1D7−01 TCGA−DM−A1D6−01 TCGA−DM−A0X9−01 TCGA−DC−6683−01 TCGA−DC−6160−01 TCGA−D5−7000−01 TCGA−D5−6932−01 TCGA−D5−6931−01 TCGA−D5−6930−01 TCGA−D5−6541−01 TCGA−D5−6535−01 TCGA−D5−5540−01 TCGA−CM−6678−01 TCGA−CM−4747−01 TCGA−CM−4746−01 TCGA−CL−5917−01 TCGA−CK−4947−01 TCGA−AZ−6606−01 TCGA−AZ−6605−01 TCGA−AZ−6600−01 TCGA−AZ−5407−01 TCGA−AZ−4616−01 TCGA−AH−6644−01 TCGA−AH−6544−01 TCGA−AG−A025−01 TCGA−AG−A020−01 TCGA−AG−A00H−01 TCGA−AG−3901−01 TCGA−AG−3887−01 TCGA−AG−3878−01 TCGA−AG−3742−01 TCGA−AG−3731−01 TCGA−AG−3726−01 TCGA−AF−6672−01 TCGA−AF−6655−01 TCGA−AF−2691−01 TCGA−AD−6965−01 TCGA−AD−6901−01 TCGA−AD−6548−01 TCGA−AA−A03J−01 TCGA−AA−A03F−01 TCGA−AA−A02Y−01 TCGA−AA−A02O−01 TCGA−AA−A01I−01 TCGA−AA−3939−01 TCGA−AA−3854−01 TCGA−AA−3852−01 TCGA−AA−3848−01 TCGA−AA−3837−01 TCGA−AA−3818−01 TCGA−AA−3696−01 TCGA−AA−3673−01 TCGA−AA−3655−01 TCGA−AA−3558−01 TCGA−AA−3502−01 TCGA−A6−6782−01 TCGA−A6−6654−01 TCGA−A6−6653−01 TCGA−A6−6138−01 TCGA−A6−5659−01 TCGA−A6−5657−01 TCGA−A6−4105−01 TCGA−A6−3808−01 TCGA−G4−6306−01 TCGA−F5−6812−01 TCGA−F5−6702−01 TCGA−F4−6806−01 TCGA−DY−A1H8−01 TCGA−DY−A1DF−01 TCGA−DM−A28K−01 TCGA−DM−A282−01 TCGA−DM−A1D4−01 TCGA−DM−A1D0−01 TCGA−DC−6155−01 TCGA−D5−5537−01 TCGA−CM−6163−01 TCGA−CM−5863−01 TCGA−CM−4744−01 TCGA−CI−6620−01 TCGA−CA−6716−01 TCGA−CA−5796−01 TCGA−AZ−6607−01 TCGA−AG−A032−01 TCGA−AG−A02X−01 TCGA−AG−A01W−01 TCGA−AG−A015−01 TCGA−AG−A014−01 TCGA−AG−A00Y−01 TCGA−AG−A00C−01 TCGA−AG−A008−01 TCGA−AG−4008−01 TCGA−AG−4005−01 TCGA−AG−3999−01 TCGA−AG−3909−01 TCGA−AG−3902−01 TCGA−AG−3896−01 TCGA−AG−3885−01 TCGA−AG−3727−01 TCGA−AG−3611−01 TCGA−AG−3605−01 TCGA−AG−3602−01 TCGA−AG−3599−01 TCGA−AG−3594−01 TCGA−AG−3586−01 TCGA−AG−3583−01 TCGA−AG−3581−01 TCGA−AG−3580−01 TCGA−AG−3575−01 TCGA−AF−5654−01 TCGA−AF−4110−01 TCGA−AF−2692−01 TCGA−AF−2689−01 TCGA−AA−A02W−01 TCGA−AA−A029−01 TCGA−AA−A01Z−01 TCGA−AA−A01X−01 TCGA−AA−A01G−01 TCGA−AA−A01F−01 TCGA−AA−A00Q−01 TCGA−AA−A00K−01 TCGA−AA−A00A−01 TCGA−AA−3994−01 TCGA−AA−3986−01 TCGA−AA−3979−01 TCGA−AA−3975−01 TCGA−AA−3941−01 TCGA−AA−3930−01 TCGA−AA−3870−01 TCGA−AA−3851−01 TCGA−AA−3844−01 TCGA−AA−3842−01 TCGA−AA−3814−01 TCGA−AA−3695−01 TCGA−AA−3681−01 TCGA−AA−3680−01 TCGA−AA−3561−01 TCGA−AA−3560−01 TCGA−AA−3556−01 TCGA−AA−3555−01 TCGA−AA−3548−01 TCGA−AA−3532−01 TCGA−AA−3530−01 TCGA−AA−3522−01 TCGA−AA−3521−01 TCGA−AA−3520−01 TCGA−A6−5664−01 TCGA−A6−2683−01

TCGA−AG−A01Y−01 TCGA−AA−3672−01 TCGA−F4−6856−01 TCGA−CM−5861−01 TCGA−AA−3524−01 TCGA−D5−6532−01 TCGA−AA−3693−01 TCGA−CM−6162−01 TCGA−A6−5665−01 TCGA−G4−6309−01 TCGA−AA−A01P−01 TCGA−AA−3715−01 TCGA−A6−2676−01 TCGA−CM−6171−01 TCGA−D5−5538−01 TCGA−AU−6004−01 TCGA−AD−6895−01 TCGA−AG−A02N−01 TCGA−AA−A01Q−01 TCGA−DT−5265−01 TCGA−CA−6718−01 TCGA−AA−3845−01 TCGA−AA−3695−01 TCGA−AZ−4315−01 TCGA−AA−A00N−01 TCGA−CM−6165−01 TCGA−AZ−6608−01 TCGA−AG−4007−01 TCGA−AA−3986−01 TCGA−AA−3496−01 TCGA−AA−A010−01 TCGA−AD−6964−01 TCGA−AA−3984−01 TCGA−EI−6508−01 TCGA−EI−6507−01 TCGA−D5−6930−01 TCGA−CK−5916−01 TCGA−CK−5912−01 TCGA−AA−3966−01 TCGA−AA−3864−01 TCGA−AA−3811−01 TCGA−AA−3529−01 TCGA−AA−3492−01 TCGA−AG−A002−01 TCGA−G4−6588−01 TCGA−F4−6570−01 TCGA−AD−6889−01 TCGA−G4−6628−01 TCGA−AZ−6598−01 TCGA−AA−3663−01 TCGA−AA−3510−01 TCGA−G5−6235−01 TCGA−G4−6625−01 TCGA−G4−6323−01 TCGA−G4−6317−01 TCGA−G4−6304−01 TCGA−F5−6811−01 TCGA−EI−6506−01 TCGA−DY−A0XA−01 TCGA−DM−A28G−01 TCGA−DM−A28F−01 TCGA−DM−A1DB−01 TCGA−DM−A1D6−01 TCGA−DM−A0XF−01 TCGA−D5−6898−01 TCGA−D5−6540−01 TCGA−D5−6539−01 TCGA−D5−6537−01 TCGA−D5−6535−01 TCGA−D5−6529−01 TCGA−CM−6168−01 TCGA−CM−5862−01 TCGA−CM−5348−01 TCGA−CM−4752−01 TCGA−CM−4743−01 TCGA−CK−4952−01 TCGA−CK−4950−01 TCGA−CA−6717−01 TCGA−AZ−6601−01 TCGA−AZ−6600−01 TCGA−AZ−6599−01 TCGA−AY−6386−01 TCGA−AY−6196−01 TCGA−AG−3892−01 TCGA−AF−6655−01 TCGA−AF−2693−01 TCGA−AD−6901−01 TCGA−AA−3713−01 TCGA−AA−3710−01 TCGA−AA−3660−01 TCGA−AA−3489−01 TCGA−A6−6142−01 TCGA−A6−6138−01 TCGA−A6−5666−01 TCGA−A6−5662−01 TCGA−A6−5660−01

Signalling To P38 Via RIT And RIN FDR = 1.9e−12%, FDR nod = 0.072% Signaling By FGFR3 Fusions In Cancer FDR = 1.9e−12%, FDR nod = 2.1%

GDF3

GDF5

GDF6

BMP10

BMP15

BMP5

BMP6

BMP2

BMP3

BMPR1B

MAML2

BMP4

GDF10

GDF11

GDF2

GDF7

GDF9

MAML1

MAML3

MSTN

SMAD1

SMAD5

SMAD9

wt BMPR1A wt

wt BAX wt

known HCG mut RBL2 known HCG mut

known HCG mut BMPR2 known HCG mut

wt wt

unknown CG mut SMAD4 unknown CG mut

CREBBP

EP300

WT1

SMAD2

SMARCA4

SMAD3

BMP7

PIK3CA BRAF NRAS PIK3R1 PRKD1 PIK3C3 PIK3CG PRKCG PIK3C2B PRKCQ ETS1 PLCG2 ARAF CASP9 KDR PIK3C2A PLCG1 PRKCA PRKCE PRKCH AKT1 HIF1A MAPK1 MAPK14 NOS3 PIK3CB PIK3CD PIK3R3 PLA2G4A PRKCB PRKD3 RAF1 HRAS HSPB1 MAP2K1 MAP2K2 MAPK3 MAPKAPK2 MAPKAPK3 PIK3R2 PRKCD PRKCI PRKCZ PRKD2 PTK2 PXN RAC1 RAC2 RAC3 SH2D2A SHC2 SPHK1 SPHK2 VEGFA

TCGA−D5−6534−01 TCGA−F4−6855−01 TCGA−AA−A01R−01 TCGA−AA−3678−01 TCGA−AA−A00A−01 TCGA−CM−6674−01 TCGA−AA−3950−01 TCGA−CM−6678−01 TCGA−F5−6465−01 TCGA−AA−3688−01 TCGA−CK−6746−01 TCGA−AZ−6603−01 TCGA−A6−5661−01 TCGA−A6−5657−01 TCGA−D5−6928−01 TCGA−AA−3510−01 TCGA−F4−6570−01 TCGA−AA−3966−01 TCGA−G4−6588−01 TCGA−AZ−4315−01 TCGA−CM−5861−01 TCGA−AD−6895−01 TCGA−AA−A022−01 TCGA−AA−A01Q−01 TCGA−A6−3809−01 TCGA−AG−A002−01 TCGA−AA−3864−01 TCGA−AY−6386−01 TCGA−AA−A00N−01 TCGA−AA−A00J−01 TCGA−AD−6889−01 TCGA−AA−3715−01 TCGA−AA−3554−01 TCGA−A6−6781−01 TCGA−A6−6780−01 TCGA−A6−6141−01 TCGA−G5−6641−01 TCGA−CK−5913−01 TCGA−CA−5796−01 TCGA−AA−A00R−01 TCGA−AA−3877−01 TCGA−AA−3555−01 TCGA−AA−3527−01 TCGA−A6−6653−01 TCGA−CA−6717−01 TCGA−AA−A010−01 TCGA−A6−5665−01 TCGA−D5−6931−01 TCGA−AA−3663−01 TCGA−G4−6293−01 TCGA−EI−6507−01 TCGA−DM−A1D0−01 TCGA−CM−4743−01 TCGA−AZ−6608−01 TCGA−AZ−6605−01 TCGA−AZ−6598−01 TCGA−AU−6004−01 TCGA−AF−2687−01 TCGA−AD−5900−01 TCGA−AA−3977−01 TCGA−G5−6235−01 TCGA−G4−6628−01 TCGA−G4−6626−01 TCGA−G4−6323−01 TCGA−F5−6813−01 TCGA−EI−6510−01 TCGA−DY−A1DF−01 TCGA−DY−A0XA−01 TCGA−DM−A28H−01 TCGA−DM−A1DA−01 TCGA−DC−6682−01 TCGA−DC−5337−01 TCGA−D5−6923−01 TCGA−D5−6541−01 TCGA−D5−6539−01 TCGA−D5−5540−01 TCGA−D5−5538−01 TCGA−CM−6679−01 TCGA−CM−6677−01 TCGA−CM−6171−01 TCGA−CM−6169−01 TCGA−CM−6162−01 TCGA−CM−5868−01 TCGA−CM−5864−01 TCGA−CM−4752−01 TCGA−CM−4746−01 TCGA−CK−4952−01 TCGA−CI−6619−01 TCGA−CA−6718−01 TCGA−AZ−5407−01 TCGA−AY−6197−01 TCGA−AG−A036−01 TCGA−AG−3999−01 TCGA−AG−3742−01 TCGA−AG−3732−01 TCGA−AF−4110−01 TCGA−AA−A01K−01 TCGA−AA−A01G−01 TCGA−AA−3949−01 TCGA−AA−3811−01 TCGA−AA−3679−01 TCGA−AA−3662−01 TCGA−AA−3655−01 TCGA−AA−3558−01 TCGA−A6−6654−01 TCGA−A6−5659−01 TCGA−A6−5656−01 TCGA−A6−2676−01 TCGA−G4−6625−01 TCGA−G4−6586−01 TCGA−G4−6321−01 TCGA−G4−6317−01 TCGA−G4−6315−01 TCGA−G4−6310−01 TCGA−G4−6307−01 TCGA−G4−6306−01 TCGA−G4−6304−01 TCGA−G4−6303−01 TCGA−G4−6299−01 TCGA−F5−6812−01 TCGA−F5−6702−01 TCGA−F5−6571−01 TCGA−F5−6464−01 TCGA−F4−6856−01 TCGA−F4−6854−01 TCGA−F4−6808−01 TCGA−F4−6807−01 TCGA−F4−6806−01 TCGA−F4−6805−01 TCGA−F4−6704−01 TCGA−F4−6703−01 TCGA−F4−6460−01 TCGA−F4−6459−01 TCGA−EI−6508−01 TCGA−EI−6506−01 TCGA−EF−5830−01 TCGA−DY−A1DG−01 TCGA−DY−A1DD−01 TCGA−DY−A1DC−01 TCGA−DT−5265−01 TCGA−DM−A28K−01 TCGA−DM−A28F−01 TCGA−DM−A28E−01 TCGA−DM−A285−01 TCGA−DM−A1HA−01 TCGA−DM−A1DB−01 TCGA−DM−A1D9−01 TCGA−DM−A1D8−01 TCGA−DM−A1D7−01 TCGA−DM−A1D6−01 TCGA−DM−A1D4−01 TCGA−DM−A0XF−01 TCGA−DM−A0XD−01 TCGA−DC−6683−01 TCGA−DC−6158−01 TCGA−DC−6157−01 TCGA−DC−6155−01 TCGA−DC−5869−01 TCGA−D5−6932−01 TCGA−D5−6930−01 TCGA−D5−6929−01 TCGA−D5−6927−01 TCGA−D5−6926−01 TCGA−D5−6924−01 TCGA−D5−6922−01 TCGA−D5−6920−01 TCGA−D5−6898−01 TCGA−D5−6540−01 TCGA−D5−6538−01 TCGA−D5−6535−01 TCGA−D5−6533−01 TCGA−D5−6532−01 TCGA−D5−5541−01 TCGA−CM−6676−01 TCGA−CM−6675−01 TCGA−CM−6172−01 TCGA−CM−6168−01 TCGA−CM−6166−01 TCGA−CM−6165−01 TCGA−CM−6164−01 TCGA−CM−6163−01 TCGA−CM−6161−01 TCGA−CM−5862−01 TCGA−CM−5860−01 TCGA−CM−5349−01 TCGA−CM−5348−01 TCGA−CM−5341−01 TCGA−CM−4744−01 TCGA−CL−5918−01 TCGA−CL−5917−01 TCGA−CK−5916−01 TCGA−CK−5914−01 TCGA−CK−4950−01 TCGA−CK−4948−01 TCGA−CK−4947−01 TCGA−CI−6624−01 TCGA−CI−6622−01 TCGA−CI−6621−01 TCGA−CI−6620−01 TCGA−CA−6719−01 TCGA−CA−6716−01 TCGA−CA−5797−01 TCGA−AZ−6607−01 TCGA−AZ−6601−01 TCGA−AZ−6600−01 TCGA−AZ−6599−01 TCGA−AZ−5403−01 TCGA−AZ−4616−01 TCGA−AZ−4323−01 TCGA−AY−6196−01 TCGA−AY−5543−01 TCGA−AY−4071−01 TCGA−AY−4070−01 TCGA−AU−3779−01 TCGA−AH−6643−01 TCGA−AH−6544−01 TCGA−AG−A032−01 TCGA−AG−A02X−01 TCGA−AG−A02N−01 TCGA−AG−A026−01 TCGA−AG−A020−01 TCGA−AG−A01Y−01 TCGA−AG−A01W−01 TCGA−AG−A01L−01 TCGA−AG−A016−01 TCGA−AG−A014−01 TCGA−AG−A011−01 TCGA−AG−A00Y−01 TCGA−AG−A00C−01 TCGA−AG−4015−01 TCGA−AG−4008−01 TCGA−AG−4007−01 TCGA−AG−4005−01 TCGA−AG−3909−01 TCGA−AG−3902−01 TCGA−AG−3898−01 TCGA−AG−3896−01 TCGA−AG−3893−01 TCGA−AG−3890−01 TCGA−AG−3885−01 TCGA−AG−3882−01 TCGA−AG−3731−01 TCGA−AG−3726−01 TCGA−AG−3612−01 TCGA−AG−3611−01 TCGA−AG−3609−01 TCGA−AG−3608−01 TCGA−AG−3605−01 TCGA−AG−3602−01 TCGA−AG−3601−01 TCGA−AG−3598−01 TCGA−AG−3594−01 TCGA−AG−3587−01 TCGA−AG−3581−01 TCGA−AG−3578−01 TCGA−AG−3575−01 TCGA−AF−6672−01 TCGA−AF−6655−01 TCGA−AF−6136−01 TCGA−AF−3913−01 TCGA−AF−3400−01 TCGA−AF−2693−01 TCGA−AF−2691−01 TCGA−AF−2689−01 TCGA−AD−6965−01 TCGA−AD−6963−01 TCGA−AD−6901−01 TCGA−AD−6899−01 TCGA−AD−6888−01 TCGA−AD−6548−01 TCGA−AA−A03J−01 TCGA−AA−A02W−01 TCGA−AA−A02J−01 TCGA−AA−A02H−01 TCGA−AA−A02F−01 TCGA−AA−A01Z−01 TCGA−AA−A01T−01 TCGA−AA−A01S−01 TCGA−AA−A01F−01 TCGA−AA−A01D−01 TCGA−AA−A00W−01 TCGA−AA−A00L−01 TCGA−AA−A00F−01 TCGA−AA−A00E−01 TCGA−AA−A00D−01 TCGA−AA−3982−01 TCGA−AA−3980−01 TCGA−AA−3979−01 TCGA−AA−3976−01 TCGA−AA−3975−01 TCGA−AA−3972−01 TCGA−AA−3956−01 TCGA−AA−3930−01 TCGA−AA−3875−01 TCGA−AA−3869−01 TCGA−AA−3867−01 TCGA−AA−3866−01 TCGA−AA−3860−01 TCGA−AA−3858−01 TCGA−AA−3856−01 TCGA−AA−3851−01 TCGA−AA−3848−01 TCGA−AA−3844−01 TCGA−AA−3842−01 TCGA−AA−3815−01 TCGA−AA−3814−01 TCGA−AA−3713−01 TCGA−AA−3712−01 TCGA−AA−3697−01 TCGA−AA−3693−01 TCGA−AA−3685−01 TCGA−AA−3681−01 TCGA−AA−3667−01 TCGA−AA−3666−01 TCGA−AA−3660−01 TCGA−AA−3562−01 TCGA−AA−3561−01 TCGA−AA−3560−01 TCGA−AA−3556−01 TCGA−AA−3553−01 TCGA−AA−3552−01 TCGA−AA−3549−01 TCGA−AA−3542−01 TCGA−AA−3531−01 TCGA−AA−3526−01 TCGA−AA−3524−01 TCGA−AA−3520−01 TCGA−AA−3519−01 TCGA−AA−3517−01 TCGA−AA−3511−01 TCGA−AA−3492−01 TCGA−A6−6782−01 TCGA−A6−6652−01 TCGA−A6−6651−01 TCGA−A6−6649−01 TCGA−A6−6142−01 TCGA−A6−6138−01 TCGA−A6−6137−01 TCGA−A6−5662−01 TCGA−A6−4105−01 TCGA−A6−3810−01 TCGA−A6−3807−01 TCGA−A6−2683−01 TCGA−A6−2678−01 TCGA−A6−2674−01 TCGA−A6−2670−01

TCGA−AG−3601−01 TCGA−AA−3562−01 TCGA−AG−3611−01 TCGA−CI−6621−01 TCGA−AF−2689−01 TCGA−CA−6715−01 TCGA−G4−6306−01 TCGA−AG−A032−01 TCGA−AA−3870−01 TCGA−EI−6506−01 TCGA−AG−A01W−01 TCGA−CA−5254−01 TCGA−CM−5863−01 TCGA−AA−3854−01 TCGA−AA−A01Q−01 TCGA−AZ−4323−01 TCGA−CA−6716−01 TCGA−AA−A01T−01 TCGA−AA−A00A−01 TCGA−AZ−6607−01 TCGA−AA−3518−01 TCGA−A6−6651−01 TCGA−AA−3968−01 TCGA−AA−3542−01 TCGA−D5−5537−01 TCGA−AZ−6605−01 TCGA−AH−6547−01 TCGA−AG−A01Y−01 TCGA−AA−3867−01 TCGA−F5−6812−01 TCGA−AA−3710−01 TCGA−A6−6142−01 TCGA−DY−A1DF−01 TCGA−DM−A28K−01 TCGA−AA−3681−01 TCGA−AA−A00E−01 TCGA−F4−6704−01 TCGA−AZ−6600−01 TCGA−AG−A00C−01 TCGA−CK−6748−01 TCGA−AF−4110−01 TCGA−AD−6888−01 TCGA−AA−3554−01 TCGA−AG−3726−01 TCGA−D5−6922−01 TCGA−CM−6167−01 TCGA−AG−A025−01 TCGA−AA−3552−01 TCGA−AA−A01R−01 TCGA−AA−3555−01 TCGA−AA−3672−01 TCGA−AA−A02K−01 TCGA−AA−A01G−01 TCGA−AA−3531−01 TCGA−AA−3984−01 TCGA−CM−6677−01 TCGA−AA−3811−01 TCGA−AD−6901−01 TCGA−AA−3534−01 TCGA−CM−5341−01 TCGA−CK−5915−01 TCGA−A6−6781−01 TCGA−F4−6703−01 TCGA−D5−6533−01 TCGA−G4−6309−01 TCGA−AA−3845−01 TCGA−AH−6549−01 TCGA−AA−3695−01 TCGA−DM−A28F−01 TCGA−AA−3994−01 TCGA−AG−3892−01 TCGA−AA−A02F−01 TCGA−AA−3972−01 TCGA−F5−6465−01 TCGA−DC−5337−01 TCGA−D5−6932−01 TCGA−CA−5797−01 TCGA−AG−A01L−01 TCGA−AG−3894−01 TCGA−AF−3913−01 TCGA−AF−2691−01 TCGA−AA−A024−01 TCGA−AA−A00F−01 TCGA−AA−3976−01 TCGA−AA−3973−01 TCGA−AA−3819−01 TCGA−AA−3666−01 TCGA−AA−3558−01 TCGA−AA−3549−01 TCGA−A6−2678−01 TCGA−AG−A002−01 TCGA−AD−6889−01 TCGA−G4−6626−01 TCGA−AA−3516−01 TCGA−CM−5348−01 TCGA−AD−6895−01 TCGA−AA−A022−01 TCGA−A6−6653−01 TCGA−D5−6930−01 TCGA−D5−6928−01 TCGA−D5−6539−01 TCGA−AA−3949−01 TCGA−A6−2676−01 TCGA−A6−2672−01 TCGA−EI−6510−01 TCGA−DM−A1DA−01 TCGA−D5−6535−01 TCGA−CM−5868−01 TCGA−CK−5913−01 TCGA−AY−6196−01 TCGA−AA−A00J−01 TCGA−AA−3966−01 TCGA−AA−3833−01 TCGA−AA−3664−01 TCGA−AA−3525−01 TCGA−G4−6321−01 TCGA−EI−6508−01 TCGA−DM−A1D6−01 TCGA−DC−6681−01 TCGA−CM−4744−01 TCGA−AZ−6603−01 TCGA−AA−A01D−01 TCGA−AA−3821−01 TCGA−DY−A1DD−01 TCGA−DM−A1D4−01 TCGA−CM−6675−01 TCGA−CM−6170−01 TCGA−CA−5796−01 TCGA−AG−3885−01 TCGA−AG−3578−01 TCGA−AA−A01P−01 TCGA−AA−A00D−01 TCGA−AA−3684−01 TCGA−AA−3543−01 TCGA−A6−5664−01 TCGA−CA−6717−01 TCGA−AZ−4315−01 TCGA−AA−A010−01 TCGA−CA−6718−01 TCGA−G4−6586−01 TCGA−F4−6570−01 TCGA−D5−6540−01 TCGA−CM−6171−01 TCGA−A6−5661−01 TCGA−AA−A00N−01 TCGA−AA−3977−01 TCGA−AA−3947−01 TCGA−AA−3864−01 TCGA−AA−3663−01 TCGA−AA−3510−01 TCGA−AA−3492−01 TCGA−G4−6628−01 TCGA−G4−6588−01 TCGA−G4−6304−01 TCGA−D5−6536−01 TCGA−AZ−6601−01 TCGA−AZ−6598−01 TCGA−AG−A02N−01 TCGA−AA−3877−01 TCGA−A6−5665−01 TCGA−CM−6674−01 TCGA−CM−4743−01 TCGA−CK−5916−01 TCGA−AY−6197−01 TCGA−AA−3950−01 TCGA−AA−3815−01 TCGA−AA−3715−01 TCGA−CM−6161−01 TCGA−CM−5861−01 TCGA−AA−3713−01 TCGA−A6−5657−01 TCGA−G4−6625−01 TCGA−G4−6315−01 TCGA−G4−6307−01 TCGA−G4−6303−01 TCGA−F5−6811−01 TCGA−F4−6856−01 TCGA−F4−6460−01 TCGA−EI−6507−01 TCGA−DM−A28H−01 TCGA−DM−A1DB−01 TCGA−DM−A1D9−01 TCGA−D5−6534−01 TCGA−D5−6532−01 TCGA−CM−6168−01 TCGA−CM−6162−01 TCGA−CM−5864−01 TCGA−CM−5862−01 TCGA−CM−5349−01 TCGA−CM−4746−01 TCGA−CK−4948−01 TCGA−CK−4947−01 TCGA−AZ−6608−01 TCGA−AZ−5407−01 TCGA−AD−5900−01 TCGA−AA−3662−01 TCGA−AA−3660−01 TCGA−A6−6780−01 TCGA−A6−6141−01 TCGA−G4−6317−01 TCGA−DY−A1DG−01 TCGA−DM−A0XD−01 TCGA−DC−6682−01 TCGA−DC−6160−01 TCGA−DC−6158−01 TCGA−D5−6927−01 TCGA−D5−6541−01 TCGA−D5−5538−01 TCGA−CM−6680−01 TCGA−CM−6678−01 TCGA−CM−6166−01 TCGA−CM−6164−01 TCGA−CM−5860−01 TCGA−CM−4752−01 TCGA−CL−5918−01 TCGA−CK−5914−01 TCGA−CK−4952−01 TCGA−CK−4950−01 TCGA−CI−6622−01 TCGA−AZ−4682−01 TCGA−AY−6386−01 TCGA−AY−5543−01 TCGA−AU−6004−01 TCGA−AU−3779−01 TCGA−AD−6964−01 TCGA−AD−6963−01 TCGA−AA−A01V−01 TCGA−AA−3712−01 TCGA−AA−3697−01 TCGA−A6−5666−01 TCGA−A6−5656−01 TCGA−G4−6323−01 TCGA−G4−6310−01 TCGA−G4−6299−01 TCGA−G4−6293−01 TCGA−F4−6854−01 TCGA−F4−6808−01 TCGA−F4−6569−01 TCGA−F4−6459−01 TCGA−EF−5830−01 TCGA−DY−A0XA−01 TCGA−DT−5265−01 TCGA−DM−A28G−01 TCGA−DM−A28C−01 TCGA−DM−A285−01 TCGA−DM−A1D8−01 TCGA−DM−A1D7−01 TCGA−DM−A0XF−01 TCGA−DM−A0X9−01 TCGA−DC−6683−01 TCGA−D5−6931−01 TCGA−D5−6929−01 TCGA−D5−6898−01 TCGA−D5−6537−01 TCGA−D5−6529−01 TCGA−D5−5541−01 TCGA−D5−5539−01 TCGA−CM−6676−01 TCGA−CM−6172−01 TCGA−CM−6169−01 TCGA−CM−5344−01 TCGA−CK−6747−01 TCGA−CK−6746−01 TCGA−CI−6624−01 TCGA−CA−6719−01 TCGA−AZ−6606−01 TCGA−AZ−6599−01 TCGA−AH−6544−01 TCGA−AF−6136−01 TCGA−AF−2693−01 TCGA−AA−A02Y−01 TCGA−AA−A02O−01 TCGA−AA−3956−01 TCGA−AA−3850−01 TCGA−AA−3655−01 TCGA−AA−3511−01 TCGA−A6−6652−01 TCGA−A6−6649−01 TCGA−A6−5662−01 TCGA−A6−5660−01 TCGA−A6−5659−01 TCGA−A6−3809−01 TCGA−G5−6235−01 TCGA−F5−6813−01 TCGA−F5−6571−01 TCGA−F4−6855−01 TCGA−F4−6809−01 TCGA−F4−6807−01 TCGA−F4−6805−01 TCGA−DY−A1DC−01 TCGA−DM−A1HA−01 TCGA−DC−6157−01 TCGA−DC−5869−01 TCGA−D5−7000−01 TCGA−D5−6926−01 TCGA−D5−6923−01 TCGA−D5−6920−01 TCGA−D5−6538−01 TCGA−D5−5540−01 TCGA−CM−4747−01 TCGA−CL−5917−01 TCGA−CK−5912−01 TCGA−CI−6619−01 TCGA−AZ−5403−01 TCGA−AZ−4616−01 TCGA−AH−6644−01 TCGA−AH−6643−01 TCGA−AG−A020−01 TCGA−AG−A00H−01 TCGA−AG−4015−01 TCGA−AG−3901−01 TCGA−AG−3887−01 TCGA−AG−3878−01 TCGA−AG−3742−01 TCGA−AG−3731−01 TCGA−AF−6672−01 TCGA−AF−2687−01 TCGA−AD−6965−01 TCGA−AD−6899−01 TCGA−AD−6890−01 TCGA−AD−6548−01 TCGA−AA−A03J−01 TCGA−AA−A03F−01 TCGA−AA−A01K−01 TCGA−AA−A01I−01 TCGA−AA−3939−01 TCGA−AA−3866−01 TCGA−AA−3852−01 TCGA−AA−3848−01 TCGA−AA−3837−01 TCGA−AA−3818−01 TCGA−AA−3812−01 TCGA−AA−3696−01 TCGA−AA−3673−01 TCGA−AA−3496−01 TCGA−AA−3489−01 TCGA−A6−6782−01 TCGA−A6−6654−01 TCGA−A6−4105−01 TCGA−A6−3808−01

BMP Signaling Pathway ( TGF Beta BMP Diagram(MolecularVariation) ) FDR = 1.9e−12%, FDR nod = 0.014% VEGF Signaling Pathway FDR = 1.9e−12%, FDR nod = 0.053%


TP53

EP300

CCNB1

CDK1

PCNA

TFDP1

AURKA

CARM1

CDC25C E2F4

RBL1

PRMT1 SFN

TFDP2

ZNF385A

PIK3CA BRAF NRAS ITPR1 PIK3CG VAV1 PIK3R1 PIK3C3 PRKCQ PAK3 PTPRC VAV3 AKT1 AKT2 ARAF CHUK IKBKB MAPK8 PPP3CB CD3D CSK MAP2K1 MAPK1 MAPK3 MAPK9 PIK3CD PIK3R3 PLCG1 PPP3CA RAF1 AKT3 CD247 CD28 CD3E CD3G CD80 CD86 CDC42 FOS HRAS JUN LAT LCK LCP2 MAP2K2 NCK1 NCK2 NFKBIA PAK1 PAK2 PIK3CB PIK3R2 PPP3CC RAC1 SOS1 SOS2 VAV2 WAS ZAP70

TCGA−AA−3521−01 TCGA−AA−3815−01 TCGA−AA−3529−01 TCGA−A6−6142−01 TCGA−CM−4743−01 TCGA−AG−A036−01 TCGA−AA−A00N−01 TCGA−EI−6507−01 TCGA−DM−A28F−01 TCGA−CM−6172−01 TCGA−CM−5862−01 TCGA−AZ−6601−01 TCGA−AZ−4315−01 TCGA−AA−A00K−01 TCGA−AA−3856−01 TCGA−AA−3710−01 TCGA−AA−3518−01 TCGA−A6−5662−01 TCGA−G4−6588−01 TCGA−F4−6570−01 TCGA−DM−A1D6−01 TCGA−D5−6928−01 TCGA−CM−6162−01 TCGA−CM−5860−01 TCGA−CA−6717−01 TCGA−AG−A002−01 TCGA−AD−6964−01 TCGA−AD−5900−01 TCGA−AA−3950−01 TCGA−AA−3492−01 TCGA−G4−6628−01 TCGA−G4−6626−01 TCGA−G4−6625−01 TCGA−G4−6586−01 TCGA−G4−6323−01 TCGA−G4−6321−01 TCGA−G4−6310−01 TCGA−G4−6303−01 TCGA−G4−6299−01 TCGA−F5−6811−01 TCGA−F4−6460−01 TCGA−EI−6510−01 TCGA−EI−6508−01 TCGA−EF−5830−01 TCGA−DY−A1DD−01 TCGA−DT−5265−01 TCGA−DM−A28C−01 TCGA−DM−A285−01 TCGA−DM−A1DA−01 TCGA−DM−A1D7−01 TCGA−DM−A1D4−01 TCGA−DM−A0XF−01 TCGA−DM−A0XD−01 TCGA−DC−6683−01 TCGA−DC−6681−01 TCGA−DC−6160−01 TCGA−DC−6158−01 TCGA−D5−6930−01 TCGA−D5−6540−01 TCGA−D5−6539−01 TCGA−D5−6536−01 TCGA−D5−6535−01 TCGA−D5−6534−01 TCGA−D5−6529−01 TCGA−D5−5538−01 TCGA−CM−6675−01 TCGA−CM−6674−01 TCGA−CM−6171−01 TCGA−CM−6170−01 TCGA−CM−6169−01 TCGA−CM−6168−01 TCGA−CM−5868−01 TCGA−CM−5864−01 TCGA−CM−5861−01 TCGA−CM−5349−01 TCGA−CM−5348−01 TCGA−CM−4744−01 TCGA−CK−6747−01 TCGA−CK−5914−01 TCGA−CK−5913−01 TCGA−CK−4950−01 TCGA−CK−4947−01 TCGA−CA−6718−01 TCGA−CA−5796−01 TCGA−AZ−6606−01 TCGA−AZ−6603−01 TCGA−AZ−6598−01 TCGA−AZ−5407−01 TCGA−AY−6196−01 TCGA−AG−3885−01 TCGA−AG−3578−01 TCGA−AD−6963−01 TCGA−AD−6895−01 TCGA−AD−6889−01 TCGA−AA−A022−01 TCGA−AA−A01P−01 TCGA−AA−A01D−01 TCGA−AA−A00J−01 TCGA−AA−A00D−01 TCGA−AA−3966−01 TCGA−AA−3949−01 TCGA−AA−3947−01 TCGA−AA−3877−01 TCGA−AA−3833−01 TCGA−AA−3821−01 TCGA−AA−3715−01 TCGA−AA−3713−01 TCGA−AA−3712−01 TCGA−AA−3684−01 TCGA−AA−3664−01 TCGA−AA−3543−01 TCGA−AA−3525−01 TCGA−AA−3516−01 TCGA−A6−6653−01 TCGA−A6−6649−01 TCGA−A6−5665−01 TCGA−A6−5664−01 TCGA−A6−5661−01 TCGA−A6−5657−01 TCGA−A6−2676−01 TCGA−A6−2672−01

TCGA−AA−3543−01 TCGA−AA−3710−01 TCGA−CM−6679−01 TCGA−A6−2676−01 TCGA−AG−3601−01 TCGA−AA−3949−01 TCGA−AA−3516−01 TCGA−AG−A002−01 TCGA−AA−3984−01 TCGA−CM−6167−01 TCGA−A6−6781−01 TCGA−G4−6309−01 TCGA−EI−6508−01 TCGA−D5−6922−01 TCGA−AH−6549−01 TCGA−AA−3833−01 TCGA−AA−3664−01 TCGA−AA−3552−01 TCGA−DM−A1DA−01 TCGA−F5−6465−01 TCGA−DC−5337−01 TCGA−CA−5797−01 TCGA−AG−A01L−01 TCGA−AG−3894−01 TCGA−AF−3913−01 TCGA−AA−A02F−01 TCGA−AA−A024−01 TCGA−AA−A00F−01 TCGA−AA−3976−01 TCGA−AA−3973−01 TCGA−AA−3972−01 TCGA−AA−3819−01 TCGA−AA−3666−01 TCGA−AA−3549−01 TCGA−A6−2678−01 TCGA−AA−A010−01 TCGA−G4−6315−01 TCGA−G4−6307−01 TCGA−DC−6682−01 TCGA−D5−6540−01 TCGA−CM−6162−01 TCGA−CM−6161−01 TCGA−CM−5860−01 TCGA−CA−6717−01 TCGA−AY−6197−01 TCGA−AF−6136−01 TCGA−AA−3662−01 TCGA−A6−6780−01 TCGA−G4−6588−01 TCGA−G4−6310−01 TCGA−G4−6304−01 TCGA−G4−6293−01 TCGA−F5−6811−01 TCGA−F4−6460−01 TCGA−DY−A1DG−01 TCGA−DM−A28C−01 TCGA−D5−6534−01 TCGA−D5−5541−01 TCGA−CM−6680−01 TCGA−CM−6171−01 TCGA−CM−5864−01 TCGA−CM−5349−01 TCGA−CM−4752−01 TCGA−CK−5916−01 TCGA−CK−5914−01 TCGA−CA−6719−01 TCGA−AU−6004−01 TCGA−AU−3779−01 TCGA−AD−6963−01 TCGA−AA−A01V−01 TCGA−AA−3947−01 TCGA−AA−3850−01 TCGA−AA−3712−01 TCGA−AA−3697−01 TCGA−AA−3492−01 TCGA−A6−5660−01 TCGA−A6−5656−01 TCGA−G4−6628−01 TCGA−G4−6317−01 TCGA−G4−6303−01 TCGA−G4−6299−01 TCGA−F5−6813−01 TCGA−F4−6809−01 TCGA−F4−6808−01 TCGA−F4−6570−01 TCGA−F4−6569−01 TCGA−F4−6459−01 TCGA−DY−A1DC−01 TCGA−DY−A0XA−01 TCGA−DT−5265−01 TCGA−DM−A0XF−01 TCGA−DC−6158−01 TCGA−DC−6157−01 TCGA−DC−5869−01 TCGA−D5−6929−01 TCGA−D5−6926−01 TCGA−D5−6923−01 TCGA−D5−6920−01 TCGA−D5−6898−01 TCGA−CM−6676−01 TCGA−CM−6172−01 TCGA−CM−6169−01 TCGA−CM−5861−01 TCGA−CM−5344−01 TCGA−CL−5918−01 TCGA−CK−6747−01 TCGA−CK−6746−01 TCGA−CK−5912−01 TCGA−CK−4952−01 TCGA−CI−6624−01 TCGA−CI−6619−01 TCGA−AZ−5403−01 TCGA−AZ−4682−01 TCGA−AH−6643−01 TCGA−AG−4015−01 TCGA−AF−2693−01 TCGA−AF−2687−01 TCGA−AD−6899−01 TCGA−AD−6890−01 TCGA−AD−5900−01 TCGA−AA−3956−01 TCGA−AA−3950−01 TCGA−AA−3877−01 TCGA−AA−3866−01 TCGA−AA−3815−01 TCGA−AA−3812−01 TCGA−AA−3510−01 TCGA−AA−3496−01 TCGA−AA−3489−01 TCGA−A6−6652−01 TCGA−A6−6649−01 TCGA−A6−3809−01 TCGA−AZ−4315−01 TCGA−AA−A00N−01 TCGA−A6−5665−01 TCGA−DM−A1D9−01 TCGA−AD−6964−01 TCGA−G4−6625−01 TCGA−G4−6586−01 TCGA−F4−6856−01 TCGA−F4−6703−01 TCGA−EI−6507−01 TCGA−DM−A1DB−01 TCGA−DM−A1D7−01 TCGA−DM−A0XD−01 TCGA−D5−6927−01 TCGA−D5−6541−01 TCGA−D5−6538−01 TCGA−D5−6536−01 TCGA−D5−6532−01 TCGA−D5−5538−01 TCGA−CM−6674−01 TCGA−CM−6164−01 TCGA−CM−5862−01 TCGA−CM−4743−01 TCGA−CK−4950−01 TCGA−CK−4948−01 TCGA−CI−6622−01 TCGA−AZ−6608−01 TCGA−AZ−6599−01 TCGA−AZ−6598−01 TCGA−AY−5543−01 TCGA−AG−3892−01 TCGA−AD−6895−01 TCGA−AD−6889−01 TCGA−AA−3977−01 TCGA−AA−3939−01 TCGA−AA−3864−01 TCGA−AA−3715−01 TCGA−AA−3713−01 TCGA−AA−3511−01 TCGA−A6−5666−01 TCGA−A6−5661−01 TCGA−G5−6235−01 TCGA−G4−6626−01 TCGA−G4−6323−01 TCGA−F5−6571−01 TCGA−F4−6855−01 TCGA−F4−6854−01 TCGA−F4−6807−01 TCGA−F4−6805−01 TCGA−EI−6510−01 TCGA−EF−5830−01 TCGA−DM−A28H−01 TCGA−DM−A28G−01 TCGA−DM−A285−01 TCGA−DM−A1HA−01 TCGA−DM−A1D8−01 TCGA−DM−A0X9−01 TCGA−DC−6683−01 TCGA−DC−6160−01 TCGA−DC−6155−01 TCGA−D5−7000−01 TCGA−D5−6932−01 TCGA−D5−6931−01 TCGA−D5−6539−01 TCGA−D5−6537−01 TCGA−D5−6529−01 TCGA−D5−5540−01 TCGA−D5−5539−01 TCGA−CM−6678−01 TCGA−CM−6168−01 TCGA−CM−6166−01 TCGA−CM−4747−01 TCGA−CM−4746−01 TCGA−CL−5917−01 TCGA−CK−4947−01 TCGA−CA−6718−01 TCGA−AZ−6606−01 TCGA−AZ−6605−01 TCGA−AZ−6601−01 TCGA−AZ−5407−01 TCGA−AZ−4616−01 TCGA−AY−6386−01 TCGA−AH−6644−01 TCGA−AH−6544−01 TCGA−AG−A02N−01 TCGA−AG−A025−01 TCGA−AG−A020−01 TCGA−AG−A00H−01 TCGA−AG−3901−01 TCGA−AG−3887−01 TCGA−AG−3878−01 TCGA−AG−3742−01 TCGA−AG−3731−01 TCGA−AG−3726−01 TCGA−AF−6672−01 TCGA−AF−2691−01 TCGA−AD−6965−01 TCGA−AD−6548−01 TCGA−AA−A03J−01 TCGA−AA−A03F−01 TCGA−AA−A02Y−01 TCGA−AA−A02O−01 TCGA−AA−A01R−01 TCGA−AA−A01K−01 TCGA−AA−A01I−01 TCGA−AA−3854−01 TCGA−AA−3852−01 TCGA−AA−3848−01 TCGA−AA−3837−01 TCGA−AA−3818−01 TCGA−AA−3696−01 TCGA−AA−3673−01 TCGA−AA−3663−01 TCGA−AA−3660−01 TCGA−AA−3655−01 TCGA−AA−3558−01 TCGA−A6−6782−01 TCGA−A6−6654−01 TCGA−A6−6141−01 TCGA−A6−5662−01 TCGA−A6−5659−01 TCGA−A6−5657−01 TCGA−A6−4105−01 TCGA−A6−3808−01 TCGA−G4−6306−01 TCGA−F5−6812−01 TCGA−F5−6702−01 TCGA−F4−6806−01 TCGA−EI−6506−01 TCGA−DY−A1H8−01 TCGA−DY−A1DF−01 TCGA−DM−A28K−01 TCGA−DM−A282−01 TCGA−DM−A1D6−01 TCGA−DM−A1D4−01 TCGA−DM−A1D0−01 TCGA−D5−6930−01 TCGA−D5−6535−01 TCGA−D5−5537−01 TCGA−CM−6163−01 TCGA−CM−5863−01 TCGA−CM−4744−01 TCGA−CI−6620−01 TCGA−CA−6716−01 TCGA−CA−5796−01 TCGA−AZ−6607−01 TCGA−AZ−6600−01 TCGA−AG−A032−01 TCGA−AG−A02X−01 TCGA−AG−A01W−01 TCGA−AG−A015−01 TCGA−AG−A014−01 TCGA−AG−A00Y−01 TCGA−AG−A00C−01 TCGA−AG−A008−01 TCGA−AG−4008−01 TCGA−AG−4005−01 TCGA−AG−3999−01 TCGA−AG−3909−01 TCGA−AG−3902−01 TCGA−AG−3896−01 TCGA−AG−3885−01 TCGA−AG−3727−01 TCGA−AG−3611−01 TCGA−AG−3605−01 TCGA−AG−3602−01 TCGA−AG−3599−01 TCGA−AG−3594−01 TCGA−AG−3586−01 TCGA−AG−3583−01 TCGA−AG−3581−01 TCGA−AG−3580−01 TCGA−AG−3575−01 TCGA−AF−6655−01 TCGA−AF−5654−01 TCGA−AF−4110−01 TCGA−AF−2692−01 TCGA−AF−2689−01 TCGA−AD−6901−01 TCGA−AA−A02W−01 TCGA−AA−A029−01 TCGA−AA−A01Z−01 TCGA−AA−A01X−01 TCGA−AA−A01G−01 TCGA−AA−A01F−01 TCGA−AA−A00Q−01 TCGA−AA−A00K−01 TCGA−AA−A00A−01 TCGA−AA−3994−01 TCGA−AA−3986−01 TCGA−AA−3979−01 TCGA−AA−3975−01 TCGA−AA−3941−01 TCGA−AA−3930−01 TCGA−AA−3870−01 TCGA−AA−3851−01 TCGA−AA−3844−01 TCGA−AA−3842−01 TCGA−AA−3814−01 TCGA−AA−3695−01 TCGA−AA−3681−01 TCGA−AA−3680−01 TCGA−AA−3561−01 TCGA−AA−3560−01 TCGA−AA−3556−01 TCGA−AA−3555−01 TCGA−AA−3548−01 TCGA−AA−3532−01 TCGA−AA−3530−01 TCGA−AA−3522−01 TCGA−AA−3521−01 TCGA−AA−3520−01 TCGA−AA−3502−01 TCGA−A6−6653−01 TCGA−A6−6138−01 TCGA−A6−5664−01 TCGA−A6−2683−01

TP53 Regulates Transcription Of Genes Involved In G2 Cell Cycle Arrest FDR = 1.9e−12%, FDR nod = 0.011% T Cell Activation FDR = 2.1e−12%, FDR nod = 1.9%

known HCG mut known HCG mut PIK3CA

unknown CG mut unknown CG mut KRAS

BRAF

NRAS

PIK3R1

NTRK1

SOS1

GAB1

NGF

FRS2

FGFR3

RIT2

GRB2

HRAS

RIT1

TCGA−AA−A01R−01 TCGA−AA−3949−01 TCGA−D5−6529−01 TCGA−AG−3892−01 TCGA−CA−5254−01 TCGA−D5−6538−01 TCGA−AA−A00F−01 TCGA−AA−3553−01 TCGA−AA−3502−01 TCGA−AA−3975−01 TCGA−AA−3680−01 TCGA−AG−4008−01 TCGA−D5−6537−01 TCGA−DM−A28F−01 TCGA−AG−3883−01 TCGA−AA−3814−01 TCGA−F5−6571−01 TCGA−D5−6932−01 TCGA−CM−6677−01 TCGA−G4−6321−01 TCGA−F4−6856−01 TCGA−AA−A00L−01 TCGA−AA−3664−01 TCGA−AA−3833−01 TCGA−F4−6704−01 TCGA−F4−6703−01 TCGA−AA−3514−01 TCGA−A6−4105−01 TCGA−DY−A1DC−01 TCGA−AG−A036−01 TCGA−AG−3896−01 TCGA−AA−3831−01 TCGA−AA−3710−01 TCGA−AD−6901−01 TCGA−CM−4746−01 TCGA−AG−4007−01 TCGA−AA−3712−01 TCGA−AA−3529−01 TCGA−AA−3524−01 TCGA−AA−3977−01 TCGA−CM−6169−01 TCGA−AG−A01W−01 TCGA−AG−3890−01 TCGA−AG−3608−01 TCGA−AA−A024−01 TCGA−AA−A01V−01 TCGA−AA−3842−01 TCGA−AA−3696−01 TCGA−AA−3684−01 TCGA−AA−3663−01 TCGA−AA−3492−01 TCGA−CM−6674−01 TCGA−A6−5661−01 TCGA−AA−3525−01 TCGA−G4−6315−01 TCGA−DM−A1D6−01 TCGA−CM−6676−01 TCGA−CK−6747−01 TCGA−AZ−5407−01 TCGA−A6−2670−01 TCGA−CK−4952−01 TCGA−AD−6895−01 TCGA−CM−5864−01 TCGA−A6−5657−01 TCGA−G4−6306−01 TCGA−F4−6806−01 TCGA−CM−6675−01 TCGA−CL−5917−01 TCGA−CK−4947−01 TCGA−AZ−4323−01 TCGA−AA−3930−01 TCGA−AA−3544−01 TCGA−A6−5662−01 TCGA−A6−2672−01 TCGA−AD−6889−01 TCGA−AA−A00N−01 TCGA−D5−6539−01 TCGA−AA−A00J−01 TCGA−A6−6781−01 TCGA−A6−6780−01 TCGA−A6−6653−01 TCGA−G5−6235−01 TCGA−F5−6813−01 TCGA−DM−A1D0−01 TCGA−D5−6931−01 TCGA−CM−6162−01 TCGA−CK−5913−01 TCGA−AA−3554−01 TCGA−G5−6641−01 TCGA−DC−6682−01 TCGA−CI−6619−01 TCGA−AF−2687−01 TCGA−AA−A01G−01 TCGA−AA−A00R−01 TCGA−AA−3655−01 TCGA−AA−3527−01 TCGA−A6−6141−01 TCGA−AG−A002−01 TCGA−CA−6717−01 TCGA−AA−A010−01 TCGA−AA−3510−01 TCGA−AA−3815−01 TCGA−AA−3672−01 TCGA−G4−6588−01 TCGA−DM−A1DA−01 TCGA−CM−4743−01 TCGA−AZ−4315−01 TCGA−AD−5900−01 TCGA−A6−5665−01 TCGA−EI−6507−01 TCGA−AA−3715−01 TCGA−CM−6168−01 TCGA−CK−4948−01 TCGA−AG−A02N−01 TCGA−AA−A022−01 TCGA−AA−3877−01 TCGA−AA−3518−01 TCGA−AA−3516−01 TCGA−F4−6808−01 TCGA−EI−6510−01 TCGA−DM−A1HA−01 TCGA−D5−6923−01 TCGA−D5−6540−01 TCGA−D5−6535−01 TCGA−CI−6620−01 TCGA−AH−6643−01 TCGA−AA−A029−01 TCGA−AA−A00E−01 TCGA−AA−3966−01 TCGA−AA−3947−01 TCGA−G4−6307−01 TCGA−DM−A1D7−01 TCGA−D5−5537−01 TCGA−CM−6164−01 TCGA−AY−5543−01 TCGA−AH−6549−01 TCGA−AH−6544−01 TCGA−AG−3731−01 TCGA−AD−6963−01 TCGA−AA−3818−01 TCGA−AZ−6598−01 TCGA−AZ−6601−01 TCGA−AA−3984−01 TCGA−D5−6928−01 TCGA−AU−6004−01 TCGA−AD−6964−01 TCGA−AA−3662−01 TCGA−G4−6628−01 TCGA−G4−6586−01 TCGA−G4−6304−01 TCGA−CM−6171−01 TCGA−CK−6746−01 TCGA−AY−6197−01 TCGA−AA−3864−01 TCGA−CM−5861−01 TCGA−CM−5344−01 TCGA−AZ−6600−01 TCGA−AA−3950−01 TCGA−AA−3713−01 TCGA−G4−6625−01 TCGA−G4−6317−01 TCGA−G4−6310−01 TCGA−F4−6460−01 TCGA−DY−A1DG−01 TCGA−DM−A28K−01 TCGA−DM−A1D8−01 TCGA−D5−6927−01 TCGA−D5−5538−01 TCGA−CM−6161−01 TCGA−CM−5348−01 TCGA−CM−4752−01 TCGA−CA−6718−01 TCGA−AY−6386−01 TCGA−AY−6196−01 TCGA−AU−3779−01 TCGA−AA−3845−01 TCGA−AA−3555−01 TCGA−AA−3520−01 TCGA−A6−2676−01 TCGA−G4−6323−01 TCGA−G4−6309−01 TCGA−G4−6303−01 TCGA−G4−6293−01 TCGA−F5−6812−01 TCGA−F5−6465−01 TCGA−F4−6570−01 TCGA−F4−6569−01 TCGA−DY−A0XA−01 TCGA−DM−A28H−01 TCGA−DM−A1D9−01 TCGA−DC−6681−01 TCGA−D5−6930−01 TCGA−D5−6924−01 TCGA−D5−6536−01 TCGA−D5−6534−01 TCGA−D5−6533−01 TCGA−D5−6532−01 TCGA−D5−5540−01 TCGA−CM−6680−01 TCGA−CM−6166−01 TCGA−CM−5868−01 TCGA−CM−5349−01 TCGA−CK−5916−01 TCGA−CK−5914−01 TCGA−CK−4950−01 TCGA−CA−6719−01 TCGA−CA−5796−01 TCGA−AZ−6599−01 TCGA−AG−A011−01 TCGA−AG−3732−01 TCGA−AF−6672−01 TCGA−AF−6136−01 TCGA−AA−3973−01 TCGA−AA−3968−01 TCGA−AA−3821−01 TCGA−AA−3811−01 TCGA−AA−3666−01 TCGA−AA−3558−01 TCGA−A6−5664−01 TCGA−A6−5660−01 TCGA−A6−5659−01 TCGA−A6−3809−01 TCGA−G4−6626−01 TCGA−G4−6299−01 TCGA−F5−6464−01 TCGA−F4−6855−01 TCGA−F4−6805−01 TCGA−EI−6508−01 TCGA−EI−6506−01 TCGA−DY−A1DF−01 TCGA−DY−A1DD−01 TCGA−DM−A285−01 TCGA−DM−A1DB−01 TCGA−DM−A1D4−01 TCGA−DM−A0XF−01 TCGA−DC−6155−01 TCGA−DC−5337−01 TCGA−D5−7000−01 TCGA−D5−6920−01 TCGA−D5−6898−01 TCGA−D5−6541−01 TCGA−D5−5539−01 TCGA−CM−6172−01 TCGA−CM−6170−01 TCGA−CM−6165−01 TCGA−CM−6163−01 TCGA−CM−5860−01 TCGA−CK−5915−01 TCGA−CA−6716−01 TCGA−AZ−6607−01 TCGA−AZ−6605−01 TCGA−AZ−6603−01 TCGA−AZ−5403−01 TCGA−AZ−4681−01 TCGA−AZ−4616−01 TCGA−AH−6547−01 TCGA−AG−A02X−01 TCGA−AG−A020−01 TCGA−AG−A016−01 TCGA−AG−A008−01 TCGA−AG−4005−01 TCGA−AG−3901−01 TCGA−AG−3887−01 TCGA−AG−3885−01 TCGA−AF−2693−01 TCGA−AD−6899−01 TCGA−AD−6888−01 TCGA−AA−A02O−01 TCGA−AA−A01D−01 TCGA−AA−A00K−01 TCGA−AA−3861−01 TCGA−AA−3697−01 TCGA−AA−3692−01 TCGA−AA−3660−01 TCGA−AA−3530−01 TCGA−AA−3522−01 TCGA−AA−3496−01 TCGA−A6−6654−01 TCGA−A6−6652−01 TCGA−A6−6651−01 TCGA−A6−6138−01 TCGA−A6−6137−01 TCGA−A6−5656−01 TCGA−A6−2678−01

TCGA−AG−3727−01 TCGA−AA−3562−01 TCGA−AA−A01Z−01 TCGA−AA−3527−01 TCGA−CM−6165−01 TCGA−AF−2689−01 TCGA−CA−6715−01 TCGA−DY−A1DF−01 TCGA−CA−5254−01 TCGA−AZ−6607−01 TCGA−AA−3870−01 TCGA−AA−A02K−01 TCGA−D5−5537−01 TCGA−AA−3989−01 TCGA−AA−3502−01 TCGA−AA−3695−01 TCGA−AA−3688−01 TCGA−AG−3609−01 TCGA−AA−3526−01 TCGA−AA−A01Q−01 TCGA−CI−6621−01 TCGA−EI−6506−01 TCGA−AF−3400−01 TCGA−DM−A28F−01 TCGA−AF−5654−01 TCGA−CI−6620−01 TCGA−AA−3542−01 TCGA−AA−3518−01 TCGA−A6−6651−01 TCGA−DY−A1H8−01 TCGA−AA−3855−01 TCGA−A6−6138−01 TCGA−DM−A28K−01 TCGA−CM−6679−01 TCGA−AG−3575−01 TCGA−AA−A00E−01 TCGA−F4−6704−01 TCGA−AZ−6600−01 TCGA−AG−A00C−01 TCGA−AA−A01R−01 TCGA−AG−4001−01 TCGA−AG−3594−01 TCGA−AA−3556−01 TCGA−AA−3672−01 TCGA−F5−6702−01 TCGA−AG−A032−01 TCGA−AA−A00R−01 TCGA−AA−3514−01 TCGA−CK−5915−01 TCGA−CM−6677−01 TCGA−CM−5341−01 TCGA−AD−6901−01 TCGA−AA−3811−01 TCGA−AA−3534−01 TCGA−AA−3555−01 TCGA−F4−6703−01 TCGA−CK−6748−01 TCGA−AF−4110−01 TCGA−AD−6888−01 TCGA−AA−3554−01 TCGA−AA−3710−01 TCGA−D5−6533−01 TCGA−AZ−6605−01 TCGA−AG−4005−01 TCGA−AA−3975−01 TCGA−AA−3845−01 TCGA−AG−3581−01 TCGA−AA−A02J−01 TCGA−A6−6781−01 TCGA−AA−3984−01 TCGA−G4−6309−01 TCGA−CM−6167−01 TCGA−AH−6549−01 TCGA−AG−3726−01 TCGA−D5−6922−01 TCGA−AG−A025−01 TCGA−AA−3552−01 TCGA−D5−6932−01 TCGA−AG−3892−01 TCGA−AF−3913−01 TCGA−AF−2691−01 TCGA−AA−3976−01 TCGA−AA−3972−01 TCGA−AA−3666−01 TCGA−AA−3558−01 TCGA−AA−3549−01 TCGA−F5−6465−01 TCGA−DC−5337−01 TCGA−CA−5797−01 TCGA−AG−A01L−01 TCGA−AG−3894−01 TCGA−AA−A02F−01 TCGA−AA−A024−01 TCGA−AA−A00F−01 TCGA−AA−3973−01 TCGA−AA−3819−01 TCGA−A6−2678−01 TCGA−AG−A002−01 TCGA−AD−6889−01 TCGA−D5−6930−01 TCGA−AA−3516−01 TCGA−G4−6626−01 TCGA−EI−6508−01 TCGA−D5−6539−01 TCGA−AD−6895−01 TCGA−AA−A022−01 TCGA−A6−6653−01 TCGA−EI−6510−01 TCGA−DM−A1DA−01 TCGA−D5−6928−01 TCGA−D5−6535−01 TCGA−AA−A00J−01 TCGA−AA−3966−01 TCGA−AA−3949−01 TCGA−AA−3833−01 TCGA−AA−3821−01 TCGA−AA−3525−01 TCGA−DM−A1D4−01 TCGA−CM−6170−01 TCGA−CM−5348−01 TCGA−CM−4744−01 TCGA−CK−5913−01 TCGA−AG−3885−01 TCGA−AA−A01P−01 TCGA−AA−3664−01 TCGA−A6−2676−01 TCGA−A6−2672−01 TCGA−G4−6321−01 TCGA−DY−A1DD−01 TCGA−DM−A1D6−01 TCGA−DC−6681−01 TCGA−CM−6675−01 TCGA−CM−5868−01 TCGA−CA−5796−01 TCGA−AZ−6603−01 TCGA−AY−6196−01 TCGA−AG−3578−01 TCGA−AA−A01D−01 TCGA−AA−A00D−01 TCGA−AA−3684−01 TCGA−AA−3543−01 TCGA−A6−5664−01 TCGA−CA−6717−01 TCGA−AA−A010−01 TCGA−AZ−4315−01 TCGA−G4−6586−01 TCGA−CM−6674−01 TCGA−A6−5665−01 TCGA−AZ−6598−01 TCGA−A6−5661−01 TCGA−CM−6171−01 TCGA−CK−5916−01 TCGA−AA−A00N−01 TCGA−AA−3977−01 TCGA−AA−3663−01 TCGA−G4−6628−01 TCGA−D5−6540−01 TCGA−CA−6718−01 TCGA−AZ−6601−01 TCGA−AD−6964−01 TCGA−AA−3864−01 TCGA−AA−3492−01 TCGA−CM−6162−01 TCGA−CM−5861−01 TCGA−AA−3947−01 TCGA−AA−3877−01 TCGA−G4−6588−01 TCGA−G4−6315−01 TCGA−EI−6507−01 TCGA−DY−A0XA−01 TCGA−CM−6168−01 TCGA−AY−6197−01 TCGA−AA−3662−01 TCGA−AA−3510−01 TCGA−A6−6780−01 TCGA−A6−6141−01 TCGA−G4−6307−01 TCGA−F4−6856−01 TCGA−F4−6570−01 TCGA−D5−6931−01 TCGA−CM−5864−01 TCGA−CM−4746−01 TCGA−AZ−6599−01 TCGA−AZ−5407−01 TCGA−AD−5900−01 TCGA−AA−3715−01 TCGA−AA−3713−01 TCGA−AA−3660−01 TCGA−G4−6304−01 TCGA−G4−6303−01 TCGA−F5−6811−01 TCGA−F4−6460−01 TCGA−EF−5830−01 TCGA−DY−A1DG−01 TCGA−DM−A28H−01 TCGA−DM−A1D9−01 TCGA−DC−6158−01 TCGA−D5−6534−01 TCGA−D5−5538−01 TCGA−CM−6164−01 TCGA−CM−6161−01 TCGA−CM−4743−01 TCGA−CK−4952−01 TCGA−CK−4950−01 TCGA−AY−5543−01 TCGA−AU−6004−01 TCGA−AA−3950−01 TCGA−AA−3815−01 TCGA−AA−3697−01 TCGA−AA−3496−01 TCGA−G4−6299−01 TCGA−DM−A1D7−01 TCGA−DM−A0XF−01 TCGA−DM−A0XD−01 TCGA−DC−6682−01 TCGA−D5−6541−01 TCGA−D5−6536−01 TCGA−D5−6532−01 TCGA−D5−5540−01 TCGA−CM−6169−01 TCGA−CM−6166−01 TCGA−CM−5349−01 TCGA−CM−4752−01 TCGA−CK−6747−01 TCGA−CK−6746−01 TCGA−CK−5914−01 TCGA−CK−4947−01 TCGA−AZ−6608−01 TCGA−AG−A02N−01 TCGA−AF−6136−01 TCGA−AA−A01V−01 TCGA−AA−3712−01 TCGA−A6−5660−01 TCGA−G5−6235−01 TCGA−G4−6625−01 TCGA−G4−6323−01 TCGA−G4−6310−01 TCGA−G4−6293−01 TCGA−F5−6571−01 TCGA−F4−6855−01 TCGA−F4−6854−01 TCGA−F4−6809−01 TCGA−F4−6569−01 TCGA−F4−6459−01 TCGA−DT−5265−01 TCGA−DM−A28G−01 TCGA−DM−A28C−01 TCGA−DM−A285−01 TCGA−DM−A1DB−01 TCGA−DM−A0X9−01 TCGA−DC−6683−01 TCGA−DC−6160−01 TCGA−D5−7000−01 TCGA−D5−6929−01 TCGA−D5−6927−01 TCGA−D5−6920−01 TCGA−D5−6898−01 TCGA−D5−6538−01 TCGA−D5−6529−01 TCGA−D5−5541−01 TCGA−CM−6680−01 TCGA−CM−6678−01 TCGA−CM−5862−01 TCGA−CM−5860−01 TCGA−CM−5344−01 TCGA−CI−6622−01 TCGA−CI−6619−01 TCGA−AZ−6606−01 TCGA−AU−3779−01 TCGA−AH−6643−01 TCGA−AG−A020−01 TCGA−AG−3887−01 TCGA−AD−6963−01 TCGA−AA−3852−01 TCGA−AA−3850−01 TCGA−AA−3812−01 TCGA−AA−3673−01 TCGA−AA−3655−01 TCGA−AA−3511−01 TCGA−AA−3489−01 TCGA−A6−6652−01 TCGA−A6−6649−01 TCGA−A6−5666−01 TCGA−A6−5662−01 TCGA−A6−5657−01 TCGA−A6−5656−01 TCGA−A6−4105−01 TCGA−A6−3809−01 TCGA−G4−6317−01 TCGA−F5−6813−01 TCGA−F4−6808−01 TCGA−F4−6807−01 TCGA−F4−6805−01 TCGA−DY−A1DC−01 TCGA−DM−A1HA−01 TCGA−DM−A1D8−01 TCGA−DC−6157−01 TCGA−DC−5869−01 TCGA−D5−6926−01 TCGA−D5−6923−01 TCGA−D5−6537−01 TCGA−D5−5539−01 TCGA−CM−6676−01 TCGA−CM−6172−01 TCGA−CM−4747−01 TCGA−CL−5918−01 TCGA−CL−5917−01 TCGA−CK−5912−01 TCGA−CK−4948−01 TCGA−CI−6624−01 TCGA−CA−6719−01 TCGA−AZ−5403−01 TCGA−AZ−4682−01 TCGA−AZ−4616−01 TCGA−AY−6386−01 TCGA−AH−6644−01 TCGA−AH−6544−01 TCGA−AG−A00H−01 TCGA−AG−4015−01 TCGA−AG−3901−01 TCGA−AG−3878−01 TCGA−AG−3742−01 TCGA−AG−3731−01 TCGA−AF−6672−01 TCGA−AF−2693−01 TCGA−AF−2687−01 TCGA−AD−6965−01 TCGA−AD−6899−01 TCGA−AD−6890−01 TCGA−AD−6548−01 TCGA−AA−A03J−01 TCGA−AA−A03F−01 TCGA−AA−A02Y−01 TCGA−AA−A02O−01 TCGA−AA−A01K−01 TCGA−AA−A01I−01 TCGA−AA−3956−01 TCGA−AA−3939−01 TCGA−AA−3866−01 TCGA−AA−3848−01 TCGA−AA−3837−01 TCGA−AA−3818−01 TCGA−AA−3696−01 TCGA−A6−6782−01 TCGA−A6−6654−01 TCGA−A6−5659−01 TCGA−A6−3808−01

Chemokine Receptors Bind Chemokines FDR = 4.8%, FDR nod = 3.9% BMP2 Signaling Pathway(through Smad) ( TGF Beta BMP Diagram(MolecularVariation) ) FDR = 1.9e−12%, FDR nod = 0.095%

TCGA−CM−6680−01 TCGA−D5−6928−01 TCGA−A6−6651−01 TCGA−CM−6674−01 TCGA−G4−6309−01 TCGA−AZ−4681−01 TCGA−AA−3877−01 TCGA−AA−3660−01 TCGA−D5−6538−01 TCGA−DM−A28E−01 TCGA−F4−6703−01 TCGA−AD−6895−01 TCGA−F4−6704−01 TCGA−F5−6464−01 TCGA−D5−6929−01 TCGA−AD−5900−01 TCGA−D5−6926−01 TCGA−CK−5916−01 TCGA−AY−6197−01 TCGA−AA−3715−01 TCGA−CM−6161−01 TCGA−AA−A03F−01 TCGA−AA−3977−01 TCGA−AA−3526−01 TCGA−AD−6889−01 TCGA−D5−5538−01 TCGA−A6−2676−01 TCGA−AG−3726−01 TCGA−AA−3855−01 TCGA−AA−3831−01 TCGA−F4−6570−01 TCGA−AA−A00A−01 TCGA−AA−3846−01 TCGA−D5−6922−01 TCGA−CK−4952−01 TCGA−AZ−6605−01 TCGA−CK−6746−01 TCGA−AA−3815−01 TCGA−DM−A1HA−01 TCGA−AA−A010−01 TCGA−G4−6626−01 TCGA−AA−A01R−01 TCGA−CM−5861−01 TCGA−G4−6315−01 TCGA−G4−6304−01 TCGA−DM−A1D6−01 TCGA−CK−5913−01 TCGA−D5−6537−01 TCGA−AA−3681−01 TCGA−A6−5662−01 TCGA−CK−4950−01 TCGA−D5−5541−01 TCGA−AD−6548−01 TCGA−A6−5666−01 TCGA−A6−5665−01 TCGA−AA−3949−01 TCGA−AG−3893−01 TCGA−AA−3950−01 TCGA−CA−6718−01 TCGA−D5−5539−01 TCGA−CM−5868−01 TCGA−AZ−6599−01 TCGA−AA−3510−01 TCGA−A6−6653−01 TCGA−CL−5918−01 TCGA−AA−A00J−01 TCGA−AA−3864−01 TCGA−AA−3837−01 TCGA−DM−A282−01 TCGA−D5−6540−01 TCGA−CM−5864−01 TCGA−CM−4743−01 TCGA−AU−6004−01 TCGA−AG−A02N−01 TCGA−AA−3555−01 TCGA−DM−A1D4−01 TCGA−AZ−6607−01 TCGA−AA−A00N−01 TCGA−D5−6924−01 TCGA−AZ−6603−01 TCGA−AA−3966−01 TCGA−AZ−4315−01 TCGA−DM−A0XF−01 TCGA−CM−4747−01 TCGA−CI−6622−01 TCGA−AA−3941−01 TCGA−AA−3713−01 TCGA−AA−3560−01 TCGA−A6−6782−01 TCGA−A6−3808−01 TCGA−CA−6717−01 TCGA−AG−3892−01 TCGA−AA−3845−01 TCGA−AA−3678−01 TCGA−CM−6169−01 TCGA−AG−A00H−01 TCGA−AG−A008−01 TCGA−AG−4015−01 TCGA−AA−3972−01 TCGA−AA−3710−01 TCGA−AA−3543−01 TCGA−A6−5664−01 TCGA−AG−A002−01 TCGA−AA−3984−01 TCGA−AA−3663−01 TCGA−A6−6781−01 TCGA−AZ−6598−01 TCGA−G4−6586−01 TCGA−D5−6927−01 TCGA−AY−6196−01 TCGA−AU−3779−01 TCGA−AF−2693−01 TCGA−AA−A022−01 TCGA−AA−3814−01 TCGA−G4−6588−01 TCGA−G4−6303−01 TCGA−CM−6170−01 TCGA−CM−5344−01 TCGA−CK−5912−01 TCGA−AA−3695−01 TCGA−AA−3692−01 TCGA−AA−3522−01 TCGA−A6−6780−01

TCGA−AA−3514−01 TCGA−CM−5864−01 TCGA−D5−6529−01 TCGA−CA−5254−01 TCGA−AA−3833−01 TCGA−F4−6704−01 TCGA−AA−3664−01 TCGA−CA−6715−01 TCGA−AG−3594−01 TCGA−AA−A01P−01 TCGA−AA−3678−01 TCGA−CK−4952−01 TCGA−AA−3663−01 TCGA−AA−3492−01 TCGA−G4−6315−01 TCGA−DM−A1D6−01 TCGA−CM−6676−01 TCGA−CM−6674−01 TCGA−CK−6747−01 TCGA−AZ−5407−01 TCGA−AD−6895−01 TCGA−AA−3525−01 TCGA−A6−5661−01 TCGA−A6−2670−01 TCGA−D5−6539−01 TCGA−AA−A00N−01 TCGA−CM−6162−01 TCGA−AD−6889−01 TCGA−AA−A00J−01 TCGA−AA−3554−01 TCGA−G5−6641−01 TCGA−G5−6235−01 TCGA−F5−6813−01 TCGA−DM−A1D0−01 TCGA−DC−6682−01 TCGA−D5−6931−01 TCGA−CK−5913−01 TCGA−CI−6619−01 TCGA−AF−2687−01 TCGA−AA−A01G−01 TCGA−AA−A00R−01 TCGA−AA−3655−01 TCGA−AA−3527−01 TCGA−A6−6781−01 TCGA−A6−6780−01 TCGA−A6−6653−01 TCGA−A6−6141−01 TCGA−AG−A002−01 TCGA−CA−6717−01 TCGA−AD−5900−01 TCGA−G4−6588−01 TCGA−AA−A010−01 TCGA−AA−3510−01 TCGA−EI−6507−01 TCGA−DM−A1HA−01 TCGA−DM−A1DA−01 TCGA−D5−6540−01 TCGA−CM−4743−01 TCGA−AZ−4315−01 TCGA−AA−3715−01 TCGA−AA−3672−01 TCGA−A6−5665−01 TCGA−F4−6808−01 TCGA−EI−6510−01 TCGA−CK−4948−01 TCGA−AA−A022−01 TCGA−AA−A00E−01 TCGA−AA−3966−01 TCGA−AA−3947−01 TCGA−AA−3877−01 TCGA−AA−3815−01 TCGA−AA−3518−01 TCGA−AA−3516−01 TCGA−G4−6307−01 TCGA−DM−A1D7−01 TCGA−D5−6923−01 TCGA−D5−6535−01 TCGA−D5−5537−01 TCGA−CM−6168−01 TCGA−CM−6164−01 TCGA−CI−6620−01 TCGA−AY−5543−01 TCGA−AH−6643−01 TCGA−AH−6549−01 TCGA−AH−6544−01 TCGA−AG−A02N−01 TCGA−AG−3731−01 TCGA−AD−6963−01 TCGA−AA−A029−01 TCGA−AA−3818−01 TCGA−AA−3713−01 TCGA−G4−6628−01 TCGA−G4−6586−01 TCGA−G4−6304−01 TCGA−CM−5861−01 TCGA−AY−6197−01 TCGA−AU−6004−01 TCGA−AD−6964−01 TCGA−AA−3984−01 TCGA−AA−3864−01 TCGA−G4−6309−01 TCGA−F4−6570−01 TCGA−F4−6460−01 TCGA−DM−A28K−01 TCGA−D5−6930−01 TCGA−D5−6928−01 TCGA−CM−5344−01 TCGA−CK−6746−01 TCGA−AZ−6601−01 TCGA−AZ−6598−01 TCGA−AY−6386−01 TCGA−AU−3779−01 TCGA−AA−3950−01 TCGA−AA−3662−01 TCGA−AA−3555−01 TCGA−G4−6625−01 TCGA−G4−6323−01 TCGA−G4−6317−01 TCGA−G4−6293−01 TCGA−F5−6812−01 TCGA−DM−A28H−01 TCGA−DM−A1D9−01 TCGA−DM−A1D8−01 TCGA−D5−6927−01 TCGA−D5−6536−01 TCGA−D5−6532−01 TCGA−D5−5540−01 TCGA−D5−5539−01 TCGA−D5−5538−01 TCGA−CM−6680−01 TCGA−CM−6171−01 TCGA−CM−5868−01 TCGA−CM−5349−01 TCGA−CM−4752−01 TCGA−CK−5916−01 TCGA−CK−5914−01 TCGA−CA−5796−01 TCGA−AZ−6599−01 TCGA−AY−6196−01 TCGA−AG−3732−01 TCGA−AA−3973−01 TCGA−AA−3811−01 TCGA−AA−3520−01 TCGA−AA−3496−01 TCGA−A6−6654−01 TCGA−A6−5660−01 TCGA−A6−5659−01 TCGA−A6−3809−01 TCGA−G4−6626−01 TCGA−G4−6310−01 TCGA−G4−6303−01 TCGA−G4−6299−01 TCGA−F5−6465−01 TCGA−F5−6464−01 TCGA−F4−6855−01 TCGA−F4−6805−01 TCGA−F4−6569−01 TCGA−EI−6508−01 TCGA−EI−6506−01 TCGA−DY−A1DG−01 TCGA−DY−A1DF−01 TCGA−DY−A1DD−01 TCGA−DY−A0XA−01 TCGA−DM−A285−01 TCGA−DM−A1DB−01 TCGA−DM−A1D4−01 TCGA−DM−A0XF−01 TCGA−DC−6681−01 TCGA−DC−6155−01 TCGA−DC−5337−01 TCGA−D5−7000−01 TCGA−D5−6924−01 TCGA−D5−6920−01 TCGA−D5−6898−01 TCGA−D5−6541−01 TCGA−D5−6534−01 TCGA−D5−6533−01 TCGA−CM−6172−01 TCGA−CM−6170−01 TCGA−CM−6166−01 TCGA−CM−6165−01 TCGA−CM−6163−01 TCGA−CM−6161−01 TCGA−CM−5860−01 TCGA−CM−5348−01 TCGA−CK−5915−01 TCGA−CK−4950−01 TCGA−CA−6719−01 TCGA−CA−6718−01 TCGA−CA−6716−01 TCGA−AZ−6607−01 TCGA−AZ−6605−01 TCGA−AZ−6603−01 TCGA−AZ−6600−01 TCGA−AZ−5403−01 TCGA−AZ−4681−01 TCGA−AZ−4616−01 TCGA−AH−6547−01 TCGA−AG−A02X−01 TCGA−AG−A020−01 TCGA−AG−A016−01 TCGA−AG−A011−01 TCGA−AG−A008−01 TCGA−AG−4005−01 TCGA−AG−3901−01 TCGA−AG−3887−01 TCGA−AG−3885−01 TCGA−AF−6672−01 TCGA−AF−6136−01 TCGA−AF−2693−01 TCGA−AD−6899−01 TCGA−AD−6888−01 TCGA−AA−A02O−01 TCGA−AA−A01D−01 TCGA−AA−A00K−01 TCGA−AA−3968−01 TCGA−AA−3861−01 TCGA−AA−3845−01 TCGA−AA−3821−01 TCGA−AA−3697−01 TCGA−AA−3692−01 TCGA−AA−3666−01 TCGA−AA−3660−01 TCGA−AA−3558−01 TCGA−AA−3530−01 TCGA−AA−3522−01 TCGA−A6−6652−01 TCGA−A6−6651−01 TCGA−A6−6138−01 TCGA−A6−6137−01 TCGA−A6−5664−01 TCGA−A6−5656−01 TCGA−A6−2678−01 TCGA−A6−2676−01

TCGA−AA−3538−01 TCGA−AZ−6601−01 TCGA−G5−6235−01 TCGA−AZ−6600−01 TCGA−AA−3949−01 TCGA−G4−6625−01 TCGA−G4−6304−01 TCGA−AA−3818−01 TCGA−AA−A02J−01 TCGA−AA−3655−01 TCGA−AZ−6608−01 TCGA−AD−6548−01 TCGA−AA−A022−01 TCGA−AA−3663−01 TCGA−A6−6780−01 TCGA−AA−3516−01 TCGA−AA−3489−01 TCGA−A6−2671−01 TCGA−AG−3892−01 TCGA−AD−6889−01 TCGA−AA−3525−01 TCGA−G4−6310−01 TCGA−G4−6293−01 TCGA−D5−6541−01 TCGA−CM−5861−01 TCGA−AA−3662−01 TCGA−D5−6533−01 TCGA−G4−6317−01 TCGA−AF−3913−01 TCGA−AA−A00R−01 TCGA−AA−3947−01 TCGA−AA−3543−01 TCGA−CM−6678−01 TCGA−CM−5860−01 TCGA−CK−5916−01 TCGA−CK−5912−01 TCGA−AA−3855−01 TCGA−AA−3815−01 TCGA−AA−3510−01 TCGA−F4−6570−01 TCGA−DM−A1HA−01 TCGA−D5−6536−01 TCGA−D5−6532−01 TCGA−AD−5900−01 TCGA−AA−3514−01 TCGA−AA−A00N−01 TCGA−D5−6930−01 TCGA−AU−3779−01 TCGA−AA−3672−01 TCGA−F4−6856−01 TCGA−F4−6806−01 TCGA−CM−6161−01 TCGA−A6−2676−01 TCGA−AA−A010−01 TCGA−CA−6718−01 TCGA−G4−6588−01 TCGA−CM−4743−01 TCGA−AA−3715−01 TCGA−A6−6141−01 TCGA−A6−5661−01 TCGA−DC−6158−01 TCGA−CI−6624−01 TCGA−AZ−5403−01 TCGA−AA−A01R−01 TCGA−AA−3864−01 TCGA−G4−6628−01 TCGA−AG−A002−01 TCGA−AA−3977−01 TCGA−D5−6928−01 TCGA−CA−6717−01 TCGA−CM−6171−01 TCGA−CM−6162−01 TCGA−EI−6507−01 TCGA−AY−6196−01 TCGA−AD−6964−01 TCGA−AA−3710−01 TCGA−G4−6586−01 TCGA−CK−4952−01 TCGA−CK−4948−01 TCGA−AY−6197−01 TCGA−AD−6895−01 TCGA−AA−A01P−01 TCGA−A6−6781−01 TCGA−A6−5665−01 TCGA−A6−5657−01

TCGA−AF−5654−01 TCGA−CI−6624−01 TCGA−A6−2671−01 TCGA−A6−2683−01 TCGA−AA−3949−01 TCGA−AA−3713−01 TCGA−AA−3975−01 TCGA−G4−6304−01 TCGA−AD−6901−01 TCGA−F4−6856−01 TCGA−CI−6619−01 TCGA−DM−A282−01 TCGA−AG−4007−01 TCGA−G4−6309−01 TCGA−AY−6386−01 TCGA−AZ−6608−01 TCGA−AH−6644−01 TCGA−D5−5539−01 TCGA−AA−A00A−01 TCGA−G4−6299−01 TCGA−CM−5864−01 TCGA−AG−3902−01 TCGA−D5−6532−01 TCGA−AH−6549−01 TCGA−AF−4110−01 TCGA−AG−3575−01 TCGA−AA−A022−01 TCGA−AA−3866−01 TCGA−CM−6678−01 TCGA−CM−5860−01 TCGA−CK−5912−01 TCGA−CM−6162−01 TCGA−F4−6569−01 TCGA−CM−6674−01 TCGA−AA−3956−01 TCGA−F4−6460−01 TCGA−D5−6931−01 TCGA−AA−3870−01 TCGA−AA−3710−01 TCGA−D5−6922−01 TCGA−CK−4952−01 TCGA−AZ−6605−01 TCGA−AA−3845−01 TCGA−AA−3837−01 TCGA−CM−4752−01 TCGA−AA−A01Q−01 TCGA−AA−3947−01 TCGA−CM−6168−01 TCGA−CK−5915−01 TCGA−AZ−5403−01 TCGA−AA−A01F−01 TCGA−A6−5659−01 TCGA−D5−6928−01 TCGA−AA−3950−01 TCGA−F4−6459−01 TCGA−AG−A032−01 TCGA−AA−3821−01 TCGA−AZ−6601−01 TCGA−DM−A1D8−01 TCGA−AA−3846−01 TCGA−AG−A00Y−01 TCGA−AA−3562−01 TCGA−EF−5830−01 TCGA−AD−6895−01 TCGA−A6−6653−01 TCGA−D5−5540−01 TCGA−AG−3999−01 TCGA−G4−6586−01 TCGA−F4−6808−01 TCGA−CM−5862−01 TCGA−A6−6780−01 TCGA−CA−6715−01 TCGA−AA−3673−01 TCGA−AA−3715−01 TCGA−G4−6628−01 TCGA−G4−6317−01 TCGA−AZ−5407−01 TCGA−D5−7000−01 TCGA−CM−5349−01 TCGA−AA−3994−01 TCGA−AA−3663−01 TCGA−AZ−6598−01 TCGA−CA−5254−01 TCGA−DY−A1DG−01 TCGA−AG−4015−01 TCGA−AG−3584−01 TCGA−AA−A00R−01 TCGA−A6−5661−01 TCGA−F4−6703−01 TCGA−AA−3877−01 TCGA−AA−3955−01 TCGA−AA−3815−01 TCGA−AA−3672−01 TCGA−CK−6751−01 TCGA−AF−2687−01 TCGA−AA−A02O−01 TCGA−AA−3971−01 TCGA−D5−6920−01 TCGA−AA−A00E−01 TCGA−AA−3697−01 TCGA−A6−5660−01 TCGA−EI−6506−01 TCGA−DM−A285−01 TCGA−DM−A1DB−01 TCGA−CM−6165−01 TCGA−AG−A00C−01 TCGA−AA−3662−01 TCGA−F4−6570−01 TCGA−CK−5913−01 TCGA−AD−5900−01 TCGA−CM−4743−01 TCGA−AA−3516−01 TCGA−DM−A1DA−01 TCGA−CM−5861−01 TCGA−AG−A02N−01 TCGA−AA−A01P−01 TCGA−AA−3552−01 TCGA−AG−3892−01 TCGA−EI−6507−01 TCGA−CK−5916−01 TCGA−AA−3811−01 TCGA−DY−A1DC−01 TCGA−DM−A28C−01 TCGA−DC−6160−01 TCGA−D5−5538−01 TCGA−CK−4950−01 TCGA−AU−6004−01 TCGA−AG−3732−01 TCGA−AD−6889−01 TCGA−AA−A01I−01 TCGA−AA−3525−01 TCGA−AA−3510−01 TCGA−AA−3864−01 TCGA−A6−5665−01 TCGA−AA−3492−01 TCGA−D5−6540−01 TCGA−DM−A28H−01 TCGA−D5−6538−01 TCGA−D5−6536−01 TCGA−CM−6171−01 TCGA−AZ−6599−01 TCGA−AA−3818−01 TCGA−G4−6303−01 TCGA−CM−4744−01 TCGA−AZ−6607−01 TCGA−AY−6197−01 TCGA−AG−A01L−01 TCGA−AG−3583−01 TCGA−AA−3972−01 TCGA−AG−A002−01 TCGA−CA−6717−01 TCGA−AA−A010−01 TCGA−AA−A00N−01 TCGA−CA−6718−01 TCGA−A6−6781−01 TCGA−G4−6588−01 TCGA−G4−6315−01 TCGA−AZ−4315−01 TCGA−AA−3984−01 TCGA−AA−3977−01 TCGA−AD−6964−01 TCGA−AA−A00J−01 TCGA−G4−6306−01 TCGA−AF−6136−01 TCGA−AA−3989−01 TCGA−AA−3855−01 TCGA−AA−3555−01 TCGA−DM−A1D4−01 TCGA−D5−6930−01 TCGA−CK−6746−01 TCGA−AG−A011−01 TCGA−AG−3612−01 TCGA−AG−3600−01 TCGA−AF−3913−01 TCGA−AA−3875−01 TCGA−AA−3666−01 TCGA−AA−3558−01 TCGA−AA−3542−01 TCGA−AA−3518−01 TCGA−A6−6141−01

IFN Gamma Signaling Pathway(JAK1 JAK2 STAT1) ( IFN Gamma Signaling(JAK1 JAK2 STAT1) ) FDR = 2.5e−12%, FDR nod = 2.3e−11% IFN Gamma Pathway FDR = 1.9e−12%, FDR nod = 0.26%


JAK2


wt wt

JAK1

STAT1

IFNG

IFNGR1

IFNGR2

PIK3CA MTOR CREBBP EP300 PIK3R1 DAPK1 PTPN11 JAK2 CBL CAMK2A CAMK2B CAMK2D IRF9 AKT1 IRF1 JAK1 MAP2K1 MAPK1 MAPK3 PIAS4 PTPN2 RAP1B CALM2 CALM3 CAMK2G CASP1 CEBPB CRKL IFNG IFNGR1 IL1B MAP3K11 PIAS1 PRKCD PTGES2 RAP1A RAPGEF1 SMAD7 STAT1 STAT3

unknown CG mut

JAK1 known HCG mut

STAT1

unknown CG mut

IFNAR1 wt

IFNA2

SMAD4

CREBBP

EP300

ZNF423

BMPR1A

BMP2

BMPR1B

SMAD1

BAMBI

SMAD6

SMAD7

STAT3

wt IFNA1


known HCG mut STAT3

STAT2

IFNA10 IFNA5 TYK2

IFNA14

IFNA21

IFNAR2 IFNA13

IFNA16

IFNA17 IFNA4

IFNA8

IFNA6

IFNA7 IRF9

LIFR OSMR IL12RB2 CSF3R IL13RA2 IL18R1 LEPR IL6ST CNTFR CSF2RA IL1R2 IL2RB IL7R CSF2RB CXCR1 GHR IL1R1 IFNAR1 IL17RA MPL PRLR CXCR2 IL2RA IL2RG IL6R IL9R EPOR IFNAR2 IL10RA IL10RB IL12RB1 IL13RA1 IL15RA IL1RAP IFNGR1 IFNGR2 IL3RA IL4R IL5RA PTPN6 SOCS3

wt wt BMPR2

IFN Alpha Signaling Pathway((JAK1 TYK2 STAT1 STAT2) ( IFN Alpha Signaling(JAK1 TYK2 STAT1 STAT2 STAT3) ) IFN Alpha Signaling Pathway(JAK1 TYK2 STAT1 STAT3) ( IFN Alpha Signaling(JAK1 TYK2 STAT1 STAT2 STAT3) ) IFN Alpha Signaling Pathway(JAK1 TYK2 STAT1) ( IFN Alpha Signaling(JAK1 TYK2 STAT1 STAT2 STAT3) ) IFN Alpha Signaling Pathway(JAK1 TYK2 STAT3) ( IFN Alpha Signaling(JAK1 TYK2 STAT1 STAT2 STAT3) ) FDR = 2.5%, FDR nod = 2.5% Cytokine Receptor Degradation Signaling ( JAK STAT Pathway And Regulation Pathway Diagram ) Negative Regulation Of (Phosphorylation Of Cytokine Receptor) In JAK STAT Pathway ( JAK STAT Pathway And Regulation Pathway Diagram ) FDR = 2.3%, FDR nod = 1.3%

unknown CG mut ACKR3 ACKR2 CCR3 CCR8 XCR1 CCR1 CCR5 ACKR4 CCR2 CCR7 CX3CL1 CCR9 CCRL2 CXCR1 CXCR2 CXCR4 XCL2 CCL27 CCL7 CXCL12 CXCL8 CXCR3 CCL11 CCL16 CCL17 CCL28 CCR10 CCR4 CX3CR1 CXCL11 CXCL16 CXCL5 CXCL9 CXCR6 PF4 CCL1 CCL22 CCL25 CCR6 CXCL10 CXCL6 CXCR5 PPBP XCL1 unknown CG mut

TCGA−AD−5900−01 TCGA−AF−6136−01 TCGA−AA−3877−01 TCGA−AZ−4315−01 TCGA−A6−6654−01 TCGA−G4−6588−01 TCGA−DC−6158−01 TCGA−CM−4743−01 TCGA−CI−6624−01 TCGA−AZ−5403−01 TCGA−AA−A01R−01 TCGA−AA−3864−01 TCGA−AA−3715−01 TCGA−A6−6141−01 TCGA−A6−5661−01 TCGA−AA−3977−01 TCGA−D5−6928−01 TCGA−CM−6162−01 TCGA−G4−6628−01 TCGA−G4−6586−01 TCGA−EI−6507−01 TCGA−CM−6171−01 TCGA−CK−4952−01 TCGA−CK−4948−01 TCGA−AY−6197−01 TCGA−AD−6964−01 TCGA−AD−6895−01 TCGA−AA−A01P−01 TCGA−AA−3710−01 TCGA−A6−6781−01 TCGA−A6−5657−01 TCGA−CA−6717−01 TCGA−AG−A002−01 TCGA−CA−6718−01 TCGA−A6−5665−01 TCGA−G4−6309−01 TCGA−AZ−6598−01 TCGA−AY−6196−01 TCGA−AA−A010−01 TCGA−AA−A00N−01 TCGA−G4−6625−01 TCGA−G4−6293−01 TCGA−F4−6807−01 TCGA−F4−6704−01 TCGA−F4−6569−01 TCGA−EI−6508−01 TCGA−EF−5830−01 TCGA−DM−A0XD−01 TCGA−DC−6683−01 TCGA−DC−5869−01 TCGA−D5−6929−01 TCGA−D5−6541−01 TCGA−D5−6533−01 TCGA−D5−6532−01 TCGA−CM−6170−01 TCGA−CM−6169−01 TCGA−CM−6161−01 TCGA−CM−5868−01 TCGA−CM−5862−01 TCGA−CM−5860−01 TCGA−CM−4746−01 TCGA−CK−6746−01 TCGA−CA−6719−01 TCGA−AZ−6607−01 TCGA−AZ−6606−01 TCGA−AZ−4616−01 TCGA−AY−5543−01 TCGA−AU−6004−01 TCGA−AF−6672−01 TCGA−AA−A02K−01 TCGA−AA−3984−01 TCGA−AA−3966−01 TCGA−AA−3950−01 TCGA−AA−3815−01 TCGA−AA−3713−01 TCGA−AA−3662−01 TCGA−AA−3660−01 TCGA−A6−5666−01 TCGA−A6−5662−01

TCGA−AA−3514−01 TCGA−AA−A01Q−01 TCGA−AA−3930−01 TCGA−AA−3819−01 TCGA−AG−A032−01 TCGA−AA−3870−01 TCGA−EI−6506−01 TCGA−AA−A01P−01 TCGA−AA−3831−01 TCGA−AZ−6605−01 TCGA−D5−6928−01 TCGA−AA−3538−01 TCGA−AA−A02H−01 TCGA−AA−3526−01 TCGA−CM−5863−01 TCGA−AA−3846−01 TCGA−D5−6930−01 TCGA−AA−3994−01 TCGA−AZ−6603−01 TCGA−AZ−6600−01 TCGA−AA−3968−01 TCGA−D5−6533−01 TCGA−AY−6196−01 TCGA−F4−6704−01 TCGA−CM−6170−01 TCGA−AZ−6607−01 TCGA−AA−A02K−01 TCGA−G4−6306−01 TCGA−DY−A1H8−01 TCGA−DY−A1DD−01 TCGA−DM−A28F−01 TCGA−CM−6675−01 TCGA−CK−5915−01 TCGA−AG−A036−01 TCGA−AF−4110−01 TCGA−AA−A01R−01 TCGA−DM−A28E−01 TCGA−DY−A1DF−01 TCGA−AG−3902−01 TCGA−AG−3582−01 TCGA−AA−3986−01 TCGA−AA−3941−01 TCGA−AA−3855−01 TCGA−AD−6895−01 TCGA−G4−6626−01 TCGA−EI−6508−01 TCGA−D5−6922−01 TCGA−CM−6167−01 TCGA−AG−A025−01 TCGA−AG−3726−01 TCGA−AA−3833−01 TCGA−AA−3664−01 TCGA−AA−3552−01 TCGA−AD−6889−01 TCGA−A6−6653−01 TCGA−CM−5868−01 TCGA−CK−5913−01 TCGA−AA−A00J−01 TCGA−G5−6641−01 TCGA−DM−A1D0−01 TCGA−D5−6539−01 TCGA−CA−5796−01 TCGA−AG−3732−01 TCGA−AA−A01G−01 TCGA−AA−A00R−01 TCGA−AA−3554−01 TCGA−AA−3527−01 TCGA−AA−3966−01 TCGA−D5−6535−01 TCGA−AA−A022−01 TCGA−AA−3811−01 TCGA−AA−3672−01 TCGA−EI−6510−01 TCGA−DM−A1DA−01 TCGA−D5−5537−01 TCGA−AH−6549−01 TCGA−AA−3518−01 TCGA−AA−3516−01 TCGA−F5−6812−01 TCGA−CI−6620−01 TCGA−AA−A029−01 TCGA−AA−A00E−01 TCGA−AA−3973−01 TCGA−AG−A002−01 TCGA−G4−6309−01 TCGA−AA−3984−01 TCGA−A6−6781−01 TCGA−AG−3892−01 TCGA−AA−3555−01 TCGA−CA−6716−01 TCGA−AA−3949−01 TCGA−AA−3710−01 TCGA−DM−A28K−01 TCGA−AA−3821−01 TCGA−F4−6806−01 TCGA−DM−A282−01 TCGA−DM−A1D4−01 TCGA−AA−A00K−01 TCGA−AA−3980−01 TCGA−AA−3867−01 TCGA−AA−3854−01 TCGA−AA−3666−01 TCGA−A6−6651−01 TCGA−CA−6717−01 TCGA−AA−A010−01 TCGA−AZ−4315−01 TCGA−G4−6628−01 TCGA−AA−3977−01 TCGA−AZ−6598−01 TCGA−AA−3815−01 TCGA−G4−6588−01 TCGA−AU−6004−01 TCGA−AD−5900−01 TCGA−AA−3715−01 TCGA−AA−3713−01 TCGA−AA−3663−01 TCGA−AA−3510−01 TCGA−A6−5665−01 TCGA−EI−6507−01 TCGA−CM−6171−01 TCGA−CM−4743−01 TCGA−CA−6718−01 TCGA−AY−5543−01 TCGA−AA−A00N−01 TCGA−AA−3877−01 TCGA−AA−3864−01 TCGA−AA−3662−01 TCGA−A6−5661−01 TCGA−G4−6586−01 TCGA−G4−6307−01 TCGA−CM−6162−01 TCGA−CM−5862−01 TCGA−CM−4752−01 TCGA−AZ−6601−01 TCGA−AD−6964−01 TCGA−A6−6141−01 TCGA−F4−6570−01 TCGA−EF−5830−01 TCGA−DM−A1HA−01 TCGA−DM−A1DB−01 TCGA−D5−6931−01 TCGA−D5−6540−01 TCGA−D5−6532−01 TCGA−CM−6674−01 TCGA−CM−6164−01 TCGA−CK−6746−01 TCGA−CK−4947−01 TCGA−AZ−6608−01 TCGA−AU−3779−01 TCGA−AA−3947−01 TCGA−AA−3697−01 TCGA−AA−3660−01 TCGA−AA−3511−01 TCGA−AA−3492−01 TCGA−A6−6780−01 TCGA−G4−6625−01 TCGA−G4−6310−01 TCGA−G4−6304−01 TCGA−G4−6293−01 TCGA−F4−6460−01 TCGA−DY−A0XA−01 TCGA−DM−A1D7−01 TCGA−DM−A0XD−01 TCGA−DC−6682−01 TCGA−DC−5869−01 TCGA−D5−6927−01 TCGA−D5−6923−01 TCGA−D5−6541−01 TCGA−D5−5540−01 TCGA−CM−6676−01 TCGA−CM−6161−01 TCGA−CM−5864−01 TCGA−CM−5861−01 TCGA−CM−4746−01 TCGA−CK−5916−01 TCGA−CK−5914−01 TCGA−CK−4952−01 TCGA−CK−4948−01 TCGA−CA−6719−01 TCGA−AZ−6599−01 TCGA−AY−6386−01 TCGA−AY−6197−01 TCGA−AH−6643−01 TCGA−AF−6136−01 TCGA−AF−2687−01 TCGA−AA−3950−01 TCGA−AA−3655−01 TCGA−A6−5666−01 TCGA−A6−5662−01 TCGA−A6−5657−01 TCGA−G5−6235−01 TCGA−G4−6323−01 TCGA−G4−6315−01 TCGA−G4−6303−01 TCGA−G4−6299−01 TCGA−F5−6813−01 TCGA−F4−6808−01 TCGA−F4−6807−01 TCGA−F4−6569−01 TCGA−DY−A1DG−01 TCGA−DY−A1DC−01 TCGA−DT−5265−01 TCGA−DM−A28H−01 TCGA−DM−A1D9−01 TCGA−DM−A1D8−01 TCGA−DM−A0X9−01 TCGA−DC−6683−01 TCGA−DC−6158−01 TCGA−D5−6929−01 TCGA−D5−6920−01 TCGA−D5−6538−01 TCGA−D5−6536−01 TCGA−D5−6534−01 TCGA−D5−5541−01 TCGA−D5−5538−01 TCGA−CM−6680−01 TCGA−CM−6678−01 TCGA−CM−6172−01 TCGA−CM−6169−01 TCGA−CM−6168−01 TCGA−CM−6166−01 TCGA−CM−5860−01 TCGA−CM−5349−01 TCGA−CM−5344−01 TCGA−CK−6747−01 TCGA−CK−4950−01 TCGA−CI−6624−01 TCGA−CI−6619−01 TCGA−AZ−6606−01 TCGA−AZ−5407−01 TCGA−AZ−5403−01 TCGA−AZ−4682−01 TCGA−AZ−4616−01 TCGA−AH−6544−01 TCGA−AG−A02N−01 TCGA−AG−4015−01 TCGA−AG−3742−01 TCGA−AG−3731−01 TCGA−AF−6672−01 TCGA−AF−2693−01 TCGA−AD−6963−01 TCGA−AD−6548−01 TCGA−AA−3956−01 TCGA−AA−3818−01 TCGA−AA−3712−01 TCGA−A6−6654−01 TCGA−A6−5660−01 TCGA−A6−5659−01 TCGA−A6−5656−01 TCGA−A6−4105−01 TCGA−G4−6317−01 TCGA−F5−6811−01 TCGA−F5−6571−01 TCGA−F4−6856−01 TCGA−F4−6855−01 TCGA−F4−6854−01 TCGA−F4−6809−01 TCGA−F4−6805−01 TCGA−F4−6459−01 TCGA−DM−A28G−01 TCGA−DM−A28C−01 TCGA−DM−A285−01 TCGA−DM−A0XF−01 TCGA−DC−6160−01 TCGA−DC−6157−01 TCGA−D5−7000−01 TCGA−D5−6926−01 TCGA−D5−6898−01 TCGA−D5−6537−01 TCGA−D5−6529−01 TCGA−D5−5539−01 TCGA−CM−4747−01 TCGA−CL−5918−01 TCGA−CL−5917−01 TCGA−CK−5912−01 TCGA−CI−6622−01 TCGA−AH−6644−01 TCGA−AG−A020−01 TCGA−AG−A00H−01 TCGA−AG−3901−01 TCGA−AG−3887−01 TCGA−AG−3878−01 TCGA−AD−6965−01 TCGA−AD−6899−01 TCGA−AD−6890−01 TCGA−AA−A03J−01 TCGA−AA−A03F−01 TCGA−AA−A02Y−01 TCGA−AA−A02O−01 TCGA−AA−A01V−01 TCGA−AA−A01K−01 TCGA−AA−A01I−01 TCGA−AA−3939−01 TCGA−AA−3866−01 TCGA−AA−3852−01 TCGA−AA−3850−01 TCGA−AA−3848−01 TCGA−AA−3837−01 TCGA−AA−3812−01 TCGA−AA−3696−01 TCGA−AA−3673−01 TCGA−AA−3496−01 TCGA−AA−3489−01 TCGA−A6−6782−01 TCGA−A6−6652−01 TCGA−A6−6649−01 TCGA−A6−3809−01 TCGA−A6−3808−01

IRF3 Mediated Activation Of Type 1 IFN FDR = 0.04%, FDR nod = 0.056% IL 6 Type Cytokine Receptor Ligand Interactions FDR = 1.4e−09%, FDR nod = 1.2e−09%

TCGA−D5−6928−01 TCGA−G4−6306−01 TCGA−D5−6929−01 TCGA−CM−6168−01 TCGA−AA−A02F−01 TCGA−AA−3984−01 TCGA−AY−6386−01 TCGA−F4−6807−01 TCGA−CK−5913−01 TCGA−AZ−6608−01 TCGA−AZ−6599−01 TCGA−AA−3977−01 TCGA−AA−3710−01 TCGA−F4−6570−01 TCGA−CL−5918−01 TCGA−CM−5349−01 TCGA−CM−4743−01 TCGA−AZ−6601−01 TCGA−AZ−4323−01 TCGA−AU−3779−01 TCGA−AG−A02N−01 TCGA−AA−A01Q−01 TCGA−AA−3877−01 TCGA−A6−5665−01 TCGA−AG−A002−01 TCGA−AG−3892−01 TCGA−AD−6889−01 TCGA−F4−6805−01 TCGA−CA−6717−01 TCGA−AZ−5403−01 TCGA−AG−4005−01 TCGA−AG−3584−01 TCGA−AD−6888−01 TCGA−AA−A00D−01 TCGA−AA−3950−01 TCGA−AA−3713−01 TCGA−A6−5661−01 TCGA−A6−2683−01 TCGA−AA−A010−01 TCGA−CM−6172−01 TCGA−CK−4948−01 TCGA−CA−6718−01 TCGA−AZ−6598−01 TCGA−AA−3845−01 TCGA−G4−6628−01 TCGA−F5−6812−01 TCGA−DM−A1DA−01 TCGA−DC−5337−01 TCGA−D5−6539−01 TCGA−D5−6535−01 TCGA−CM−6171−01 TCGA−CK−6746−01 TCGA−CK−4952−01 TCGA−CK−4947−01 TCGA−CA−6716−01 TCGA−AY−6196−01 TCGA−AG−A00Y−01 TCGA−AG−3727−01 TCGA−AD−6901−01 TCGA−AD−6899−01 TCGA−AD−6548−01 TCGA−AA−A00N−01 TCGA−AA−3986−01 TCGA−AA−3966−01 TCGA−AA−3952−01 TCGA−AA−3864−01 TCGA−AA−3861−01 TCGA−AA−3814−01 TCGA−AA−3672−01 TCGA−AA−3492−01 TCGA−A6−6141−01 TCGA−A6−5666−01

TCGA−A6−2672−01 TCGA−AG−A016−01 TCGA−DM−A1HA−01 TCGA−D5−6540−01 TCGA−A6−2676−01 TCGA−DM−A1D6−01 TCGA−D5−6928−01 TCGA−CM−6171−01 TCGA−G4−6309−01 TCGA−D5−6922−01 TCGA−AA−A01R−01 TCGA−AA−3710−01 TCGA−AA−3986−01 TCGA−AA−3713−01 TCGA−CM−5861−01 TCGA−CM−4743−01 TCGA−DM−A0XD−01 TCGA−D5−6534−01 TCGA−CM−6677−01 TCGA−CK−6746−01 TCGA−EI−6507−01 TCGA−CM−6172−01 TCGA−AZ−6600−01 TCGA−AZ−4681−01 TCGA−AH−6547−01 TCGA−AA−A00R−01 TCGA−AA−A00J−01 TCGA−AA−3524−01 TCGA−AZ−6598−01 TCGA−AG−3892−01 TCGA−CM−6674−01 TCGA−AA−3672−01 TCGA−A6−5661−01 TCGA−D5−6931−01 TCGA−D5−6930−01 TCGA−AA−3950−01 TCGA−AA−3525−01 TCGA−AA−3516−01 TCGA−DM−A28G−01 TCGA−D5−6536−01 TCGA−CK−5916−01 TCGA−CA−5796−01 TCGA−AG−A01Y−01 TCGA−AG−4001−01 TCGA−AG−3593−01 TCGA−AD−5900−01 TCGA−AA−3977−01 TCGA−AA−3695−01 TCGA−AA−3684−01 TCGA−AA−3662−01 TCGA−AA−3660−01 TCGA−AA−3502−01 TCGA−CA−6717−01 TCGA−AA−A010−01 TCGA−AG−A002−01 TCGA−AA−3715−01 TCGA−G4−6588−01 TCGA−G4−6628−01 TCGA−G4−6586−01 TCGA−AZ−4315−01 TCGA−AG−A02N−01 TCGA−AD−6889−01 TCGA−AA−A00N−01 TCGA−AA−3984−01 TCGA−A6−5665−01 TCGA−G4−6304−01 TCGA−F4−6856−01 TCGA−F4−6854−01 TCGA−DM−A28H−01 TCGA−CM−6161−01 TCGA−CK−4952−01 TCGA−CA−6718−01 TCGA−AZ−6601−01 TCGA−AA−3864−01 TCGA−AA−3811−01 TCGA−AA−3663−01 TCGA−AA−3492−01 TCGA−A6−6781−01 TCGA−A6−6780−01 TCGA−A6−6141−01 TCGA−G5−6235−01 TCGA−G4−6625−01 TCGA−G4−6317−01 TCGA−G4−6315−01 TCGA−G4−6307−01 TCGA−G4−6306−01 TCGA−G4−6303−01 TCGA−G4−6293−01 TCGA−F4−6703−01 TCGA−F4−6570−01 TCGA−DM−A28K−01 TCGA−D5−6927−01 TCGA−D5−6537−01 TCGA−D5−6535−01 TCGA−D5−6532−01 TCGA−D5−5540−01 TCGA−CM−6680−01 TCGA−CM−6676−01 TCGA−CM−6166−01 TCGA−CM−5860−01 TCGA−CM−5349−01 TCGA−CK−5913−01 TCGA−CK−4948−01 TCGA−AZ−6608−01 TCGA−AZ−6607−01 TCGA−AY−6197−01 TCGA−AU−3779−01 TCGA−AG−A011−01 TCGA−AF−4110−01 TCGA−AD−6964−01 TCGA−AD−6895−01 TCGA−AA−A01P−01 TCGA−AA−3930−01 TCGA−AA−3815−01 TCGA−AA−3655−01 TCGA−A6−6653−01 TCGA−A6−5666−01 TCGA−A6−5659−01 TCGA−A6−5657−01 TCGA−A6−5656−01 TCGA−A6−3809−01

Regulation Of IFNA Signaling FDR = 1.9e−07%, FDR nod = 0.54% LRR FLII Interacting Protein 1 (LRRFIP1) Activates Type I IFN Production FDR = 1.9e−12%, FDR nod = 0.021%

wt wt MRE11A

TCGA−G4−6588−01 TCGA−AG−A02N−01 TCGA−AG−A016−01 TCGA−A6−6780−01 TCGA−A6−5665−01 TCGA−G4−6309−01 TCGA−G4−6304−01 TCGA−D5−6922−01 TCGA−AA−A01R−01 TCGA−G4−6586−01 TCGA−AA−3986−01 TCGA−AA−3713−01 TCGA−AA−3710−01 TCGA−AA−3663−01 TCGA−A6−6781−01 TCGA−AA−3715−01 TCGA−EI−6507−01 TCGA−CM−6172−01 TCGA−AZ−6600−01 TCGA−AZ−4681−01 TCGA−AH−6547−01 TCGA−AA−A00R−01 TCGA−AA−A00J−01 TCGA−AA−3984−01 TCGA−AA−3524−01 TCGA−AZ−6598−01 TCGA−AA−A010−01 TCGA−CM−6674−01 TCGA−AG−A002−01 TCGA−AG−3892−01 TCGA−AA−3672−01 TCGA−AA−3516−01 TCGA−A6−5661−01 TCGA−F4−6854−01 TCGA−DM−A28G−01 TCGA−D5−6931−01 TCGA−D5−6930−01 TCGA−D5−6536−01 TCGA−CK−5916−01 TCGA−CK−4952−01 TCGA−CA−6717−01 TCGA−CA−5796−01 TCGA−AG−A01Y−01 TCGA−AG−4001−01 TCGA−AG−3593−01 TCGA−AD−5900−01 TCGA−AA−A00N−01 TCGA−AA−3977−01 TCGA−AA−3950−01 TCGA−AA−3864−01 TCGA−AA−3695−01 TCGA−AA−3684−01 TCGA−AA−3662−01 TCGA−AA−3660−01 TCGA−AA−3525−01 TCGA−AA−3502−01

TCGA−AD−5900−01 TCGA−AA−A01R−01 TCGA−AA−3530−01 TCGA−CM−4743−01 TCGA−AA−A022−01 TCGA−AA−3663−01 TCGA−AA−3672−01 TCGA−A6−5661−01 TCGA−AG−A02N−01 TCGA−AA−A00A−01 TCGA−AA−3845−01 TCGA−D5−5541−01 TCGA−CM−5861−01 TCGA−AA−3821−01 TCGA−A6−6780−01 TCGA−F4−6808−01 TCGA−CA−6715−01 TCGA−AA−3673−01 TCGA−G4−6317−01 TCGA−D5−7000−01 TCGA−CM−5349−01 TCGA−CK−5913−01 TCGA−AZ−5407−01 TCGA−AA−3994−01 TCGA−AA−3715−01 TCGA−G4−6628−01 TCGA−G4−6586−01 TCGA−CK−4952−01 TCGA−AD−6895−01 TCGA−D5−6928−01 TCGA−CM−6162−01 TCGA−CK−4948−01 TCGA−AA−A01P−01 TCGA−AA−3710−01 TCGA−A6−5657−01 TCGA−EI−6507−01 TCGA−AG−3892−01 TCGA−DY−A1DC−01 TCGA−DM−A28C−01 TCGA−DC−6160−01 TCGA−D5−5538−01 TCGA−CK−5916−01 TCGA−CK−4950−01 TCGA−AG−3732−01 TCGA−AD−6889−01 TCGA−AA−A01I−01 TCGA−AA−3811−01 TCGA−AA−3525−01 TCGA−CM−6171−01 TCGA−AY−6197−01 TCGA−AA−3492−01 TCGA−G4−6303−01 TCGA−DM−A28H−01 TCGA−D5−6540−01 TCGA−D5−6538−01 TCGA−D5−6536−01 TCGA−CM−4744−01 TCGA−AZ−6599−01 TCGA−AG−A01L−01 TCGA−AG−3583−01 TCGA−AA−3972−01 TCGA−AA−3864−01 TCGA−AA−3818−01 TCGA−AA−3510−01 TCGA−G4−6588−01 TCGA−AZ−4315−01 TCGA−AD−6964−01 TCGA−A6−6781−01 TCGA−D5−6930−01 TCGA−AA−3977−01 TCGA−AA−3518−01 TCGA−G4−6315−01 TCGA−G4−6306−01 TCGA−DM−A1D4−01 TCGA−AG−A011−01 TCGA−AG−3612−01 TCGA−AG−3600−01 TCGA−AF−6136−01 TCGA−AF−3913−01 TCGA−AA−A00J−01 TCGA−AA−3989−01 TCGA−AA−3875−01 TCGA−AA−3855−01 TCGA−AA−3666−01 TCGA−AA−3558−01 TCGA−AA−3555−01 TCGA−AA−3542−01 TCGA−A6−6141−01 TCGA−CA−6717−01 TCGA−AA−A010−01 TCGA−CA−6718−01 TCGA−AG−A002−01 TCGA−AA−A00N−01 TCGA−AA−3984−01 TCGA−A6−5665−01 TCGA−CK−6746−01 TCGA−AU−6004−01 TCGA−G4−6293−01 TCGA−CM−5862−01 TCGA−AZ−6607−01 TCGA−AZ−6598−01 TCGA−AY−6196−01 TCGA−AA−3815−01 TCGA−G4−6625−01 TCGA−G4−6309−01 TCGA−F4−6807−01 TCGA−F4−6704−01 TCGA−F4−6569−01 TCGA−EI−6508−01 TCGA−EF−5830−01 TCGA−DM−A0XD−01 TCGA−DC−6683−01 TCGA−DC−5869−01 TCGA−D5−6929−01 TCGA−D5−6541−01 TCGA−D5−6533−01 TCGA−D5−6532−01 TCGA−CM−6170−01 TCGA−CM−6169−01 TCGA−CM−6161−01 TCGA−CM−5868−01 TCGA−CM−5860−01 TCGA−CM−4746−01 TCGA−CA−6719−01 TCGA−AZ−6606−01 TCGA−AZ−4616−01 TCGA−AY−5543−01 TCGA−AF−6672−01 TCGA−AA−A02K−01 TCGA−AA−3966−01 TCGA−AA−3950−01 TCGA−AA−3713−01 TCGA−AA−3662−01 TCGA−AA−3660−01 TCGA−A6−5666−01 TCGA−A6−5662−01

JNK Cascade ( TGF Beta Signaling(through TAK1) ) FDR = 0.38%, FDR nod = 0.45% IRF3 Mediated Induction Of Type I IFN FDR = 2.2e−07%, FDR nod = 2.2e−07%

wt wt IL6ST

known HCG mut known HCG mut OSMR

unknown CG mut unknown CG mut JAK2

NLRP4 LIFR

IL12RB2

ZBP1 JAK1

CNTFR IL11

IL27RA IL27

DTX4

TYK2

CLCF1

CRLF1

TBK1

IL11RA

IRF3 CNTF EBI3

IL12A

TMEM173 LIF

OSM

unknown CG mut unknown CG mut PRKDC

MAP2K4 NLRP4

ZBP1


MAPK10

DTX4

MAPK8 TBK1

XRCC6

MAP3K7 XRCC5

IFI16

IRF3

DDX41

MAPK9

TMEM173

TREX1

JUN


PTPN11

JAK1

STAT1 CTNNB1

IFNA1 CREBBP

IFNA5

IFNA10

PTPN6

EP300

IFNB1

IFNAR2

TYK2

USP18

IFNA13

IFNA17

LRRFIP1

IFNA14

IFNA21

IFNA4

IFNA7

IRF3

IFNA16

IFNA6

IFNA8

SOCS3

wt STAT2 wt

known HCG mut IFNA2 known HCG mut

PTPN1

IFNAR1

TCGA−A6−6653−01 TCGA−G5−6235−01 TCGA−AA−A02J−01 TCGA−AZ−6600−01 TCGA−AD−6548−01 TCGA−G4−6625−01 TCGA−CM−4744−01 TCGA−AG−3894−01 TCGA−AA−A022−01 TCGA−A6−6780−01 TCGA−AA−3949−01 TCGA−AA−3811−01 TCGA−G4−6304−01 TCGA−AA−3818−01 TCGA−AA−3663−01 TCGA−DM−A1D4−01 TCGA−CM−6164−01 TCGA−AG−3892−01 TCGA−AD−6889−01 TCGA−AA−3525−01 TCGA−AA−3510−01 TCGA−AA−3516−01 TCGA−AA−3489−01 TCGA−A6−2671−01 TCGA−G4−6293−01 TCGA−D5−6541−01 TCGA−CM−5861−01 TCGA−AA−3662−01 TCGA−D5−6533−01 TCGA−G4−6317−01 TCGA−AF−3913−01 TCGA−AA−A00R−01 TCGA−AA−3947−01 TCGA−AA−3543−01 TCGA−CM−6678−01 TCGA−CM−5860−01 TCGA−CK−5916−01 TCGA−CK−5912−01 TCGA−AA−3855−01 TCGA−AA−3815−01 TCGA−AA−3984−01 TCGA−CM−6674−01 TCGA−AZ−6603−01 TCGA−AA−A01Q−01 TCGA−AA−A00K−01 TCGA−AA−A00E−01 TCGA−AA−3713−01 TCGA−AA−A00N−01 TCGA−D5−6930−01 TCGA−CM−6161−01 TCGA−AA−3672−01 TCGA−F4−6856−01 TCGA−F4−6806−01 TCGA−AU−3779−01 TCGA−A6−2676−01 TCGA−AA−A010−01 TCGA−CM−4743−01 TCGA−AA−3864−01 TCGA−AA−3715−01 TCGA−A6−6141−01 TCGA−A6−5661−01 TCGA−DC−6158−01 TCGA−CI−6624−01 TCGA−AZ−5403−01 TCGA−AA−A01R−01 TCGA−CA−6717−01 TCGA−G4−6628−01 TCGA−D5−6928−01 TCGA−CM−6162−01 TCGA−AA−3710−01 TCGA−EI−6507−01 TCGA−CM−6171−01 TCGA−AY−6196−01 TCGA−A6−6781−01 TCGA−G4−6586−01 TCGA−CK−4952−01 TCGA−CK−4948−01 TCGA−AY−6197−01 TCGA−AD−6895−01 TCGA−AA−A01P−01 TCGA−A6−5665−01 TCGA−A6−5657−01 TCGA−AG−A002−01 TCGA−AA−3977−01 TCGA−G4−6588−01 TCGA−CA−6718−01 TCGA−AZ−6601−01 TCGA−G4−6310−01 TCGA−AZ−6608−01 TCGA−AD−6964−01 TCGA−AA−3655−01 TCGA−G4−6307−01 TCGA−G4−6306−01 TCGA−G4−6303−01 TCGA−G4−6299−01 TCGA−DY−A1H8−01 TCGA−DY−A1DD−01 TCGA−DY−A1DC−01 TCGA−DY−A0XA−01 TCGA−DM−A28F−01 TCGA−DM−A1HA−01 TCGA−DM−A0X9−01 TCGA−D5−6538−01 TCGA−D5−6535−01 TCGA−D5−6534−01 TCGA−CM−6676−01 TCGA−CM−6675−01 TCGA−CM−5862−01 TCGA−CK−6747−01 TCGA−CK−5915−01 TCGA−CK−5914−01 TCGA−AZ−6599−01 TCGA−AZ−6598−01 TCGA−AH−6643−01 TCGA−AG−A036−01 TCGA−AG−4015−01 TCGA−AF−4110−01 TCGA−AF−2693−01 TCGA−AA−3712−01 TCGA−AA−3697−01 TCGA−AA−3660−01 TCGA−AA−3555−01

TCGA−AG−A016−01 TCGA−DY−A1H8−01 TCGA−AY−4070−01 TCGA−A6−6653−01 TCGA−G5−6641−01 TCGA−G5−6235−01 TCGA−DM−A1D0−01 TCGA−D5−6931−01 TCGA−D5−6539−01 TCGA−CM−6162−01 TCGA−CM−5868−01 TCGA−CK−5913−01 TCGA−CI−6619−01 TCGA−CA−5796−01 TCGA−AY−6386−01 TCGA−AF−2687−01 TCGA−AD−6889−01 TCGA−AA−A01G−01 TCGA−AA−A00R−01 TCGA−AA−A00J−01 TCGA−AA−3555−01 TCGA−AA−3554−01 TCGA−AA−3527−01 TCGA−A6−6781−01 TCGA−A6−6141−01 TCGA−A6−5659−01 TCGA−AA−A010−01 TCGA−EI−6507−01 TCGA−DM−A1DA−01 TCGA−AU−6004−01 TCGA−AH−6643−01 TCGA−AG−A02N−01 TCGA−AG−A002−01 TCGA−AA−3966−01 TCGA−AA−3877−01 TCGA−AA−3864−01 TCGA−AA−3715−01 TCGA−AA−3713−01 TCGA−G4−6307−01 TCGA−G4−6304−01 TCGA−G4−6293−01 TCGA−F5−6812−01 TCGA−F4−6808−01 TCGA−F4−6460−01 TCGA−DM−A28H−01 TCGA−DM−A1HA−01 TCGA−DM−A1D8−01 TCGA−D5−6923−01 TCGA−D5−5538−01 TCGA−D5−5537−01 TCGA−CM−6680−01 TCGA−CM−5861−01 TCGA−CK−4948−01 TCGA−CI−6620−01 TCGA−AY−5543−01 TCGA−AH−6549−01 TCGA−AH−6544−01 TCGA−AG−3731−01 TCGA−AD−6963−01 TCGA−AD−5900−01 TCGA−AA−A029−01 TCGA−AA−A022−01 TCGA−AA−A00E−01 TCGA−AA−3984−01 TCGA−AA−3973−01 TCGA−AA−3947−01 TCGA−AA−3818−01 TCGA−AA−3815−01 TCGA−AA−3811−01 TCGA−AA−3672−01 TCGA−AA−3518−01 TCGA−AA−3516−01 TCGA−A6−5665−01 TCGA−G4−6628−01 TCGA−EI−6510−01 TCGA−CM−6168−01 TCGA−CM−6164−01 TCGA−CM−4743−01 TCGA−CA−6717−01 TCGA−AZ−4315−01 TCGA−AA−A00N−01 TCGA−AA−3662−01 TCGA−A6−6780−01 TCGA−G4−6625−01 TCGA−G4−6588−01 TCGA−G4−6586−01 TCGA−G4−6323−01 TCGA−F5−6813−01 TCGA−DM−A1D7−01 TCGA−DC−6682−01 TCGA−D5−6540−01 TCGA−D5−6538−01 TCGA−D5−6535−01 TCGA−D5−5540−01 TCGA−CM−6171−01 TCGA−CM−5349−01 TCGA−CM−5344−01 TCGA−CM−4752−01 TCGA−CK−6746−01 TCGA−CK−5916−01 TCGA−AZ−6601−01 TCGA−AZ−6599−01 TCGA−AU−3779−01 TCGA−AG−3732−01 TCGA−AD−6964−01 TCGA−AA−3655−01 TCGA−AA−3510−01 TCGA−G4−6626−01 TCGA−G4−6315−01 TCGA−G4−6303−01 TCGA−F5−6811−01 TCGA−F5−6571−01 TCGA−F5−6465−01 TCGA−F4−6856−01 TCGA−F4−6855−01 TCGA−F4−6854−01 TCGA−F4−6703−01 TCGA−F4−6569−01 TCGA−DY−A1DG−01 TCGA−DY−A1DF−01 TCGA−DY−A0XA−01 TCGA−DM−A1DB−01 TCGA−DM−A1D6−01 TCGA−DM−A1D4−01 TCGA−DM−A0XF−01 TCGA−DC−5337−01 TCGA−D5−6541−01 TCGA−D5−6537−01 TCGA−D5−6536−01 TCGA−D5−6533−01 TCGA−CM−6675−01 TCGA−CM−6163−01 TCGA−CM−5860−01 TCGA−CM−4747−01 TCGA−CM−4744−01 TCGA−CL−5917−01 TCGA−CK−5915−01 TCGA−CK−4952−01 TCGA−CA−6718−01 TCGA−AZ−6608−01 TCGA−AZ−6605−01 TCGA−AZ−6598−01 TCGA−AZ−5407−01 TCGA−AH−6547−01 TCGA−AG−A020−01 TCGA−AG−3892−01 TCGA−AG−3881−01 TCGA−AG−3575−01 TCGA−AF−6655−01 TCGA−AF−2693−01 TCGA−AD−6901−01 TCGA−AA−A01K−01 TCGA−AA−A00U−01 TCGA−AA−3831−01 TCGA−AA−3712−01 TCGA−AA−3697−01 TCGA−AA−3696−01 TCGA−AA−3663−01 TCGA−AA−3660−01 TCGA−AA−3534−01 TCGA−AA−3496−01 TCGA−A6−5661−01 TCGA−A6−5660−01 TCGA−A6−2678−01

RIG I/MDA5 Mediated Induction Of IFN Alpha/beta Pathways FDR = 0.8%, FDR nod = 0.78% Regulation Of IFNG Signaling FDR = 1.5e−11%, FDR nod = 0.0025%

PTPN1

NLRX1

PIAS1

UBA7

IFNGR1

TKFC

PTPN6

DHX58

SOCS3

RNF135

IFNG

TRIM25

IFNGR2

ISG15

PTPN2

MAVS

known HCG mut

TFDP1

SMAD3

FURIN

ZFYVE9

FKBP1A

NEDD8

TGFB1

UBE2M

TCGA−AF−2687−01 TCGA−AA−A00E−01 TCGA−AA−3852−01 TCGA−AA−3693−01 TCGA−AA−A01R−01 TCGA−AH−6644−01 TCGA−EI−6507−01 TCGA−AA−3538−01 TCGA−CM−6162−01 TCGA−G4−6315−01 TCGA−D5−6535−01 TCGA−AA−A02K−01 TCGA−AD−6889−01 TCGA−AA−3980−01 TCGA−AD−6963−01 TCGA−AA−3518−01 TCGA−F5−6702−01 TCGA−CM−6675−01 TCGA−CM−4746−01 TCGA−AD−6895−01 TCGA−CK−4947−01 TCGA−AA−A01P−01 TCGA−AD−5900−01 TCGA−DT−5265−01 TCGA−AA−3664−01 TCGA−AA−3525−01 TCGA−AA−A01Q−01 TCGA−AA−3715−01 TCGA−DM−A1D0−01 TCGA−AZ−5407−01 TCGA−AA−A022−01 TCGA−AG−3892−01 TCGA−AA−3947−01 TCGA−CM−6674−01 TCGA−AG−A026−01 TCGA−AA−3877−01 TCGA−A6−5661−01 TCGA−CA−6717−01 TCGA−D5−6931−01 TCGA−D5−6923−01 TCGA−CM−6679−01 TCGA−AZ−6608−01 TCGA−A6−6781−01 TCGA−CM−6678−01 TCGA−AA−A00J−01 TCGA−AA−3672−01 TCGA−A6−6653−01 TCGA−F4−6703−01 TCGA−AF−3913−01 TCGA−AA−3939−01 TCGA−AZ−4315−01 TCGA−AA−A010−01 TCGA−AA−3815−01 TCGA−AA−3710−01 TCGA−DY−A1DC−01 TCGA−DM−A1DA−01 TCGA−AG−A036−01 TCGA−AG−3896−01 TCGA−AA−3831−01 TCGA−DM−A28C−01 TCGA−D5−6932−01 TCGA−CI−6620−01 TCGA−AH−6549−01 TCGA−AH−6544−01 TCGA−AG−A00C−01 TCGA−AG−3878−01 TCGA−AF−4110−01 TCGA−AA−3875−01 TCGA−AA−3848−01 TCGA−G4−6588−01 TCGA−D5−6540−01 TCGA−CK−4948−01 TCGA−F4−6856−01 TCGA−CK−4952−01 TCGA−AA−3712−01 TCGA−AA−3492−01 TCGA−G4−6321−01 TCGA−DM−A1D6−01 TCGA−D5−6922−01 TCGA−D5−5537−01 TCGA−AY−5543−01 TCGA−AG−3882−01 TCGA−AG−3731−01 TCGA−A6−4105−01 TCGA−AG−A002−01 TCGA−AA−3510−01 TCGA−A6−6780−01 TCGA−AA−3663−01 TCGA−CM−6168−01 TCGA−AA−A00N−01 TCGA−AA−3977−01 TCGA−G5−6235−01 TCGA−CM−6169−01 TCGA−AG−A01W−01 TCGA−AG−3890−01 TCGA−AG−3608−01 TCGA−AA−A029−01 TCGA−AA−A024−01 TCGA−AA−A01V−01 TCGA−AA−3842−01 TCGA−AA−3696−01 TCGA−AA−3684−01 TCGA−AA−3864−01 TCGA−CA−6718−01 TCGA−AU−6004−01 TCGA−AA−3950−01 TCGA−A6−3809−01 TCGA−G4−6293−01 TCGA−DY−A0XA−01 TCGA−DM−A28K−01 TCGA−D5−6927−01 TCGA−CM−5349−01 TCGA−CA−6716−01 TCGA−AZ−6601−01 TCGA−AU−3779−01 TCGA−AA−3845−01 TCGA−AA−3555−01 TCGA−A6−2676−01 TCGA−G4−6626−01 TCGA−G4−6586−01 TCGA−G4−6310−01 TCGA−G4−6309−01 TCGA−F5−6812−01 TCGA−F5−6465−01 TCGA−F4−6855−01 TCGA−F4−6460−01 TCGA−DY−A1DD−01 TCGA−DC−5337−01 TCGA−D5−7000−01 TCGA−D5−6924−01 TCGA−D5−6920−01 TCGA−D5−6541−01 TCGA−D5−6536−01 TCGA−D5−6534−01 TCGA−D5−6533−01 TCGA−D5−6532−01 TCGA−CM−6171−01 TCGA−CM−5861−01 TCGA−CM−5348−01 TCGA−CM−4752−01 TCGA−CK−6746−01 TCGA−CK−5916−01 TCGA−CK−5915−01 TCGA−CK−4950−01 TCGA−AZ−6600−01 TCGA−AZ−6598−01 TCGA−AY−6386−01 TCGA−AY−6197−01 TCGA−AG−A011−01 TCGA−AA−3984−01 TCGA−AA−3662−01 TCGA−AA−3520−01 TCGA−A6−6654−01 TCGA−A6−6652−01 TCGA−A6−6138−01 TCGA−A6−6137−01 TCGA−A6−5660−01 TCGA−A6−5659−01 TCGA−A6−5656−01 TCGA−G4−6628−01 TCGA−G4−6625−01 TCGA−G4−6323−01 TCGA−G4−6317−01 TCGA−G4−6304−01 TCGA−G4−6303−01 TCGA−G4−6299−01 TCGA−F5−6464−01 TCGA−F4−6805−01 TCGA−F4−6570−01 TCGA−F4−6569−01 TCGA−EI−6508−01 TCGA−EI−6506−01 TCGA−DY−A1DG−01 TCGA−DY−A1DF−01 TCGA−DM−A28H−01 TCGA−DM−A285−01 TCGA−DM−A1DB−01 TCGA−DM−A1D9−01 TCGA−DM−A1D8−01 TCGA−DM−A1D4−01 TCGA−DM−A0XF−01 TCGA−DC−6681−01 TCGA−DC−6155−01 TCGA−D5−6930−01 TCGA−D5−6928−01 TCGA−D5−6898−01 TCGA−D5−5540−01 TCGA−D5−5539−01 TCGA−D5−5538−01 TCGA−CM−6680−01 TCGA−CM−6172−01 TCGA−CM−6170−01 TCGA−CM−6166−01 TCGA−CM−6165−01 TCGA−CM−6163−01 TCGA−CM−6161−01 TCGA−CM−5868−01 TCGA−CM−5860−01 TCGA−CM−5344−01 TCGA−CK−5914−01 TCGA−CA−6719−01 TCGA−CA−5796−01 TCGA−AZ−6607−01 TCGA−AZ−6605−01 TCGA−AZ−6603−01 TCGA−AZ−6599−01 TCGA−AZ−5403−01 TCGA−AZ−4681−01 TCGA−AZ−4616−01 TCGA−AY−6196−01 TCGA−AH−6547−01 TCGA−AG−A02X−01 TCGA−AG−A020−01 TCGA−AG−A016−01 TCGA−AG−A008−01 TCGA−AG−4005−01 TCGA−AG−3901−01 TCGA−AG−3887−01 TCGA−AG−3885−01 TCGA−AG−3732−01 TCGA−AF−6672−01 TCGA−AF−6136−01 TCGA−AF−2693−01 TCGA−AD−6964−01 TCGA−AD−6899−01 TCGA−AD−6888−01 TCGA−AA−A02O−01 TCGA−AA−A01D−01 TCGA−AA−A00K−01 TCGA−AA−3973−01 TCGA−AA−3968−01 TCGA−AA−3861−01 TCGA−AA−3821−01 TCGA−AA−3811−01 TCGA−AA−3713−01 TCGA−AA−3697−01 TCGA−AA−3692−01 TCGA−AA−3666−01 TCGA−AA−3660−01 TCGA−AA−3558−01 TCGA−AA−3530−01 TCGA−AA−3522−01 TCGA−AA−3496−01 TCGA−A6−6651−01 TCGA−A6−5664−01 TCGA−A6−2678−01

TCGA−CK−5913−01 TCGA−CL−5917−01 TCGA−AY−5543−01 TCGA−AG−3605−01 TCGA−AD−6889−01 TCGA−AA−3855−01 TCGA−AA−3815−01 TCGA−AA−3710−01 TCGA−DM−A1DA−01 TCGA−CK−4948−01 TCGA−AG−A036−01 TCGA−AG−3896−01 TCGA−AA−3831−01 TCGA−CA−6717−01 TCGA−AZ−4315−01 TCGA−AG−3892−01 TCGA−F4−6806−01 TCGA−D5−5541−01 TCGA−CK−6751−01 TCGA−AG−A02N−01 TCGA−AG−3598−01 TCGA−AA−A00R−01 TCGA−AA−A00J−01 TCGA−A6−6653−01 TCGA−AA−A010−01 TCGA−AA−3492−01 TCGA−DY−A1DC−01 TCGA−CK−4952−01 TCGA−G4−6588−01 TCGA−D5−6931−01 TCGA−CM−6674−01 TCGA−CM−4743−01 TCGA−CL−5918−01 TCGA−AA−A03F−01 TCGA−AA−A01R−01 TCGA−AA−A01Q−01 TCGA−AA−3514−01 TCGA−A6−6141−01 TCGA−A6−5661−01 TCGA−A6−3808−01 TCGA−AG−A002−01 TCGA−AA−A029−01 TCGA−AA−A00N−01 TCGA−AA−3977−01 TCGA−AA−3663−01 TCGA−AA−3510−01 TCGA−G5−6235−01 TCGA−CM−6169−01 TCGA−CM−6168−01 TCGA−AG−A01W−01 TCGA−AG−3890−01 TCGA−AG−3608−01 TCGA−AA−A024−01 TCGA−AA−A01V−01 TCGA−AA−3842−01 TCGA−AA−3696−01 TCGA−AA−3684−01 TCGA−A6−6780−01 TCGA−G4−6310−01 TCGA−AD−6964−01 TCGA−AA−3984−01 TCGA−AA−3864−01 TCGA−G4−6628−01 TCGA−G4−6303−01 TCGA−F5−6465−01 TCGA−F4−6460−01 TCGA−DY−A1DF−01 TCGA−DY−A0XA−01 TCGA−D5−6927−01 TCGA−D5−5540−01 TCGA−CM−6171−01 TCGA−CM−5348−01 TCGA−AZ−6600−01 TCGA−AZ−6599−01 TCGA−AG−A011−01 TCGA−AA−3968−01 TCGA−AA−3662−01 TCGA−AA−3660−01 TCGA−AA−3555−01 TCGA−AA−3520−01 TCGA−A6−6138−01 TCGA−A6−5660−01 TCGA−G4−6626−01 TCGA−G4−6625−01 TCGA−G4−6586−01 TCGA−G4−6323−01 TCGA−G4−6317−01 TCGA−G4−6309−01 TCGA−G4−6304−01 TCGA−G4−6299−01 TCGA−G4−6293−01 TCGA−F5−6812−01 TCGA−F5−6464−01 TCGA−F4−6855−01 TCGA−F4−6805−01 TCGA−F4−6570−01 TCGA−F4−6569−01 TCGA−EI−6508−01 TCGA−EI−6506−01 TCGA−DY−A1DG−01 TCGA−DY−A1DD−01 TCGA−DM−A28K−01 TCGA−DM−A28H−01 TCGA−DM−A285−01 TCGA−DM−A1DB−01 TCGA−DM−A1D9−01 TCGA−DM−A1D8−01 TCGA−DM−A1D4−01 TCGA−DM−A0XF−01 TCGA−DC−6681−01 TCGA−DC−6155−01 TCGA−DC−5337−01 TCGA−D5−7000−01 TCGA−D5−6930−01 TCGA−D5−6928−01 TCGA−D5−6924−01 TCGA−D5−6920−01 TCGA−D5−6898−01 TCGA−D5−6541−01 TCGA−D5−6536−01 TCGA−D5−6534−01 TCGA−D5−6533−01 TCGA−D5−6532−01 TCGA−D5−5539−01 TCGA−D5−5538−01 TCGA−CM−6680−01 TCGA−CM−6172−01 TCGA−CM−6170−01 TCGA−CM−6166−01 TCGA−CM−6165−01 TCGA−CM−6163−01 TCGA−CM−6161−01 TCGA−CM−5868−01 TCGA−CM−5861−01 TCGA−CM−5860−01 TCGA−CM−5349−01 TCGA−CM−5344−01 TCGA−CM−4752−01 TCGA−CK−6746−01 TCGA−CK−5916−01 TCGA−CK−5915−01 TCGA−CK−5914−01 TCGA−CK−4950−01 TCGA−CA−6719−01 TCGA−CA−6718−01 TCGA−CA−6716−01 TCGA−CA−5796−01 TCGA−AZ−6607−01 TCGA−AZ−6605−01 TCGA−AZ−6603−01 TCGA−AZ−6601−01 TCGA−AZ−6598−01 TCGA−AZ−5403−01 TCGA−AZ−4681−01 TCGA−AZ−4616−01 TCGA−AY−6386−01 TCGA−AY−6197−01 TCGA−AY−6196−01 TCGA−AU−6004−01 TCGA−AU−3779−01 TCGA−AH−6547−01 TCGA−AG−A02X−01 TCGA−AG−A020−01 TCGA−AG−A016−01 TCGA−AG−A008−01 TCGA−AG−4005−01 TCGA−AG−3901−01 TCGA−AG−3887−01 TCGA−AG−3885−01 TCGA−AG−3732−01 TCGA−AF−6672−01 TCGA−AF−6136−01 TCGA−AF−2693−01 TCGA−AD−6899−01 TCGA−AD−6888−01 TCGA−AA−A02O−01 TCGA−AA−A01D−01 TCGA−AA−A00K−01 TCGA−AA−3973−01 TCGA−AA−3950−01 TCGA−AA−3861−01 TCGA−AA−3845−01 TCGA−AA−3821−01 TCGA−AA−3811−01 TCGA−AA−3713−01 TCGA−AA−3697−01 TCGA−AA−3692−01 TCGA−AA−3666−01 TCGA−AA−3558−01 TCGA−AA−3530−01 TCGA−AA−3522−01 TCGA−AA−3496−01 TCGA−A6−6654−01 TCGA−A6−6652−01 TCGA−A6−6651−01 TCGA−A6−6137−01 TCGA−A6−5664−01 TCGA−A6−5659−01 TCGA−A6−5656−01 TCGA−A6−3809−01 TCGA−A6−2678−01 TCGA−A6−2676−01

TGFBR1

CCNC SMAD3

RNF111 ZFYVE9

MYC FKBP1A

TGIF2 TGFB1

TGF Beta Super Family Signaling Pathway(canonical) ( TGF Beta BMP Diagram(MolecularVariation) ) FDR = 1.9e−12%, FDR nod = 0.31% TGF Beta Receptor Signaling Activates SMADs FDR = 1.9e−12%, FDR nod = 0.00021%

wt wt TGFBR2

HDAC1 TGFBR1

unknown CG mut unknown CG mut SMAD4

SMAD2


wt CCNT2 SMAD2

TGIF1 unknown CG mut

unknown CG mut SMAD4

known HCG mut SMAD3 SMAD4

SMAD4 CREBBP EP300 WT1 ACVR1B SMAD2 BMPR2 INHBA SMARCA4 SMAD3 BMP7 GDF3 GDF5 GDF6 ACVR2B BMP15 BMP5 BMPR1B TGFBR1 TGFBR2 ACVR2A ACVRL1 AMHR2 BMP10 BMP2 BMP6 ACVR1 BMP3 BMP4 BMPR1A GDF10 GDF11 GDF2 GDF7 GDF9 INHA INHBB INHBC INHBE MAML1 MAML2 MAML3 MSTN NODAL SMAD1 SMAD5 SMAD9 TGFB1 TGFB2 TGFB3 CBL

TCGA−AA−3971−01 TCGA−D5−6920−01 TCGA−D5−6537−01 TCGA−CM−6678−01 TCGA−D5−6928−01 TCGA−AA−A00R−01 TCGA−CK−6747−01 TCGA−AA−3833−01 TCGA−AA−3811−01 TCGA−CK−4948−01 TCGA−AG−A02N−01 TCGA−AA−3977−01 TCGA−A6−6781−01 TCGA−AG−3742−01 TCGA−G4−6304−01 TCGA−DM−A0XF−01 TCGA−AD−6895−01 TCGA−AA−A02W−01 TCGA−AA−A00E−01 TCGA−F4−6856−01 TCGA−F4−6570−01 TCGA−CA−6718−01 TCGA−AF−6655−01 TCGA−AD−6890−01 TCGA−AD−6889−01 TCGA−AA−3968−01 TCGA−AA−3815−01 TCGA−A6−6780−01 TCGA−A6−5664−01 TCGA−A6−5661−01 TCGA−AA−A00N−01 TCGA−CM−6674−01 TCGA−CI−6624−01 TCGA−CA−5796−01 TCGA−CA−5254−01 TCGA−AZ−6601−01 TCGA−AZ−5403−01 TCGA−AA−3526−01 TCGA−A6−6654−01 TCGA−A6−6651−01 TCGA−A6−2672−01 TCGA−CA−6717−01 TCGA−AY−6197−01 TCGA−D5−5539−01 TCGA−CM−6171−01 TCGA−CK−5913−01 TCGA−CI−6622−01 TCGA−AZ−6605−01 TCGA−AG−3593−01 TCGA−AA−A01P−01 TCGA−AA−3952−01 TCGA−AA−3525−01 TCGA−A6−3809−01 TCGA−A6−5665−01 TCGA−AA−A01Q−01 TCGA−AA−3663−01 TCGA−AA−3492−01 TCGA−D5−6540−01 TCGA−AG−3892−01 TCGA−AA−3950−01 TCGA−AA−3710−01 TCGA−G4−6628−01 TCGA−D5−6929−01 TCGA−D5−6927−01 TCGA−CM−4746−01 TCGA−CK−5916−01 TCGA−CK−4952−01 TCGA−AD−6964−01 TCGA−AA−A02F−01 TCGA−AA−A01R−01 TCGA−AA−3947−01 TCGA−A6−6141−01 TCGA−AZ−6598−01 TCGA−AA−A010−01 TCGA−AZ−4315−01 TCGA−G5−6235−01 TCGA−AG−A002−01 TCGA−AA−3982−01 TCGA−AA−3715−01 TCGA−AA−3713−01 TCGA−AA−3510−01 TCGA−G4−6586−01 TCGA−G4−6307−01 TCGA−F4−6854−01 TCGA−EI−6510−01 TCGA−DM−A1D4−01 TCGA−D5−6926−01 TCGA−CM−6675−01 TCGA−CK−5914−01 TCGA−AD−6965−01 TCGA−AD−5900−01 TCGA−AA−3848−01 TCGA−AA−3555−01 TCGA−A6−6649−01 TCGA−A6−5659−01

TCGA−AA−3930−01 TCGA−AD−5900−01 TCGA−A6−6654−01 TCGA−AA−3663−01 TCGA−A6−6653−01 TCGA−AA−3949−01 TCGA−AA−3811−01 TCGA−AF−6136−01 TCGA−AA−3877−01 TCGA−AZ−4315−01 TCGA−AG−3892−01 TCGA−AA−3947−01 TCGA−CM−6674−01 TCGA−AZ−6603−01 TCGA−AA−A01Q−01 TCGA−AA−A00K−01 TCGA−AA−A00E−01 TCGA−AA−3864−01 TCGA−AA−3715−01 TCGA−DC−6158−01 TCGA−CM−4743−01 TCGA−CI−6624−01 TCGA−AZ−5403−01 TCGA−AA−A01R−01 TCGA−A6−6141−01 TCGA−A6−5661−01 TCGA−D5−6928−01 TCGA−CM−6162−01 TCGA−AD−6895−01 TCGA−A6−6781−01 TCGA−G4−6628−01 TCGA−G4−6586−01 TCGA−EI−6507−01 TCGA−CM−6171−01 TCGA−CK−4952−01 TCGA−CK−4948−01 TCGA−AY−6197−01 TCGA−AA−A01P−01 TCGA−AA−3710−01 TCGA−A6−5657−01 TCGA−AA−3977−01 TCGA−AZ−6601−01 TCGA−G4−6588−01 TCGA−AD−6964−01 TCGA−G4−6310−01 TCGA−G4−6307−01 TCGA−G4−6306−01 TCGA−G4−6303−01 TCGA−G4−6299−01 TCGA−DY−A1H8−01 TCGA−DY−A1DD−01 TCGA−DY−A1DC−01 TCGA−DY−A0XA−01 TCGA−DM−A28F−01 TCGA−DM−A1HA−01 TCGA−DM−A0X9−01 TCGA−D5−6538−01 TCGA−D5−6535−01 TCGA−D5−6534−01 TCGA−CM−6676−01 TCGA−CM−6675−01 TCGA−CK−6747−01 TCGA−CK−5915−01 TCGA−CK−5914−01 TCGA−AZ−6608−01 TCGA−AZ−6599−01 TCGA−AH−6643−01 TCGA−AG−A036−01 TCGA−AG−4015−01 TCGA−AF−4110−01 TCGA−AF−2693−01 TCGA−AA−3712−01 TCGA−AA−3697−01 TCGA−AA−3655−01 TCGA−AA−3555−01 TCGA−CA−6717−01 TCGA−AG−A002−01 TCGA−CA−6718−01 TCGA−AZ−6598−01 TCGA−AA−3984−01 TCGA−AA−3660−01 TCGA−A6−5665−01 TCGA−G4−6309−01 TCGA−CM−5862−01 TCGA−AY−6196−01 TCGA−AA−A010−01 TCGA−AA−A00N−01 TCGA−AA−3713−01 TCGA−G4−6625−01 TCGA−G4−6293−01 TCGA−F4−6807−01 TCGA−F4−6704−01 TCGA−F4−6569−01 TCGA−EI−6508−01 TCGA−EF−5830−01 TCGA−DM−A0XD−01 TCGA−DC−6683−01 TCGA−DC−5869−01 TCGA−D5−6929−01 TCGA−D5−6541−01 TCGA−D5−6533−01 TCGA−D5−6532−01 TCGA−CM−6170−01 TCGA−CM−6169−01 TCGA−CM−6161−01 TCGA−CM−5868−01 TCGA−CM−5860−01 TCGA−CM−4746−01 TCGA−CK−6746−01 TCGA−CA−6719−01 TCGA−AZ−6607−01 TCGA−AZ−6606−01 TCGA−AZ−4616−01 TCGA−AY−5543−01 TCGA−AU−6004−01 TCGA−AF−6672−01 TCGA−AA−A02K−01 TCGA−AA−3966−01 TCGA−AA−3950−01 TCGA−AA−3815−01 TCGA−AA−3662−01 TCGA−A6−5666−01 TCGA−A6−5662−01

SMAD2/SMAD3:SMAD4 Heterotrimer Regulates Transcription FDR = 1.9e−12%, FDR nod = 2.5%

SMAD2

SMAD2/3 MH2 Domain Mutants In Cancer SMAD2/3 Phosphorylation Motif Mutants In Cancer TGFBR1 KD Mutants In Cancer FDR = 2.1e−12%, FDR nod = 1.9%

CDK8 wt TGFBR2

DDX58 JAK1

wt IFIH1 wt STAT1

HERC5 JAK2

known HCG mut NLRC5 known HCG mut PTPN11


MEN1

SNW1 RBL1

SP1

CCNT1

ATP1B4 CDK9

UBC

WWTR1

E2F4

E2F5

SERPINE1 CCNK JUNB

SMAD7 TFDP2

UBA52

TCGA−DM−A0X9−01 TCGA−D5−6538−01 TCGA−CA−5254−01 TCGA−AG−4008−01 TCGA−AA−A01P−01 TCGA−AG−A014−01 TCGA−AA−A02F−01 TCGA−CL−5918−01 TCGA−AA−A01Q−01 TCGA−D5−5541−01 TCGA−AG−3598−01 TCGA−AA−3664−01 TCGA−D5−6529−01 TCGA−AA−3553−01 TCGA−AA−3502−01 TCGA−AA−3975−01 TCGA−AA−3680−01 TCGA−CI−6621−01 TCGA−AG−A00Y−01 TCGA−DM−A28F−01 TCGA−AG−3883−01 TCGA−AA−3814−01 TCGA−CM−6677−01 TCGA−F5−6571−01 TCGA−D5−6932−01 TCGA−G4−6321−01 TCGA−F4−6856−01 TCGA−AA−A00L−01 TCGA−AA−3514−01 TCGA−F4−6703−01 TCGA−A6−4105−01 TCGA−DY−A1DC−01 TCGA−AA−3710−01 TCGA−AG−A036−01 TCGA−AG−3896−01 TCGA−CM−4746−01 TCGA−AG−4007−01 TCGA−AA−3712−01 TCGA−AA−3529−01 TCGA−AA−3524−01 TCGA−AG−3892−01 TCGA−AD−6901−01 TCGA−AA−3949−01 TCGA−F4−6704−01 TCGA−D5−6537−01 TCGA−AA−A00F−01 TCGA−A6−3808−01 TCGA−DM−A28C−01 TCGA−AZ−6606−01 TCGA−AA−3492−01 TCGA−A6−5661−01 TCGA−CK−6747−01 TCGA−AZ−5407−01 TCGA−AA−3525−01 TCGA−G4−6315−01 TCGA−DM−A1D6−01 TCGA−CM−6676−01 TCGA−A6−2670−01 TCGA−AA−3663−01 TCGA−AA−3977−01 TCGA−AA−A01V−01 TCGA−CM−6169−01 TCGA−AG−A01W−01 TCGA−AG−3890−01 TCGA−AG−3608−01 TCGA−AA−A024−01 TCGA−AA−3842−01 TCGA−AA−3696−01 TCGA−AA−3684−01 TCGA−CM−6674−01 TCGA−AA−A01R−01 TCGA−AA−3833−01 TCGA−CK−6751−01 TCGA−AA−3831−01 TCGA−AA−A03F−01 TCGA−DC−6158−01 TCGA−CA−6715−01 TCGA−AG−A01L−01 TCGA−AA−3994−01 TCGA−A6−3807−01 TCGA−CK−4952−01 TCGA−AD−6895−01 TCGA−F4−6806−01 TCGA−A6−2672−01 TCGA−CM−5864−01 TCGA−A6−5657−01 TCGA−G4−6306−01 TCGA−CM−6675−01 TCGA−CL−5917−01 TCGA−CK−4947−01 TCGA−AZ−4323−01 TCGA−AA−3930−01 TCGA−AA−3544−01 TCGA−A6−5662−01 TCGA−AA−A00N−01 TCGA−AD−6889−01 TCGA−A6−6653−01 TCGA−AA−A00J−01 TCGA−CM−6162−01 TCGA−A6−6781−01 TCGA−A6−6780−01 TCGA−D5−6931−01 TCGA−D5−6539−01 TCGA−CK−5913−01 TCGA−G5−6235−01 TCGA−F5−6813−01 TCGA−DM−A1D0−01 TCGA−AA−A00R−01 TCGA−AA−3554−01 TCGA−A6−6141−01 TCGA−G5−6641−01 TCGA−DC−6682−01 TCGA−CI−6619−01 TCGA−AF−2687−01 TCGA−AA−A01G−01 TCGA−AA−3655−01 TCGA−AA−3527−01 TCGA−AG−A002−01 TCGA−AA−A010−01 TCGA−CA−6717−01 TCGA−AA−3510−01 TCGA−G4−6588−01 TCGA−CM−4743−01 TCGA−AZ−4315−01 TCGA−AA−3815−01 TCGA−AA−3672−01 TCGA−EI−6507−01 TCGA−DM−A1DA−01 TCGA−AG−A02N−01 TCGA−A6−5665−01 TCGA−AD−5900−01 TCGA−AA−A029−01 TCGA−AA−3715−01 TCGA−CM−6168−01 TCGA−AA−A022−01 TCGA−AA−3966−01 TCGA−AA−3877−01 TCGA−AA−3516−01 TCGA−D5−6540−01 TCGA−CK−4948−01 TCGA−AA−3518−01 TCGA−F4−6808−01 TCGA−EI−6510−01 TCGA−DM−A1HA−01 TCGA−D5−6923−01 TCGA−D5−6535−01 TCGA−CI−6620−01 TCGA−AH−6643−01 TCGA−AA−A00E−01 TCGA−AA−3947−01 TCGA−G4−6307−01 TCGA−DM−A1D7−01 TCGA−D5−5537−01 TCGA−CM−6164−01 TCGA−AY−5543−01 TCGA−AH−6549−01 TCGA−AH−6544−01 TCGA−AG−3731−01 TCGA−AD−6963−01 TCGA−AA−3818−01 TCGA−G4−6628−01 TCGA−AZ−6598−01 TCGA−D5−6928−01 TCGA−AZ−6601−01 TCGA−AD−6964−01 TCGA−AA−3984−01 TCGA−AA−3864−01 TCGA−G4−6586−01 TCGA−AY−6197−01 TCGA−AU−6004−01 TCGA−AA−3662−01 TCGA−G4−6304−01 TCGA−CM−6171−01 TCGA−CK−6746−01 TCGA−CA−6718−01 TCGA−F4−6460−01 TCGA−D5−6927−01 TCGA−CM−5861−01 TCGA−CM−5344−01 TCGA−AZ−6600−01 TCGA−AA−3950−01 TCGA−AA−3713−01 TCGA−AA−3555−01 TCGA−AA−3520−01 TCGA−A6−3809−01 TCGA−A6−2676−01 TCGA−G4−6625−01 TCGA−G4−6317−01 TCGA−G4−6310−01 TCGA−G4−6309−01 TCGA−G4−6303−01 TCGA−DY−A1DG−01 TCGA−DM−A28K−01 TCGA−DM−A1D8−01 TCGA−D5−6930−01 TCGA−D5−6536−01 TCGA−D5−5540−01 TCGA−D5−5538−01 TCGA−CM−6161−01 TCGA−CM−5348−01 TCGA−CM−4752−01 TCGA−CK−5916−01 TCGA−AY−6386−01 TCGA−AY−6196−01 TCGA−AU−3779−01 TCGA−AA−3968−01 TCGA−AA−3845−01 TCGA−AA−3666−01 TCGA−G4−6323−01 TCGA−G4−6293−01 TCGA−F5−6812−01 TCGA−F5−6465−01 TCGA−F4−6570−01 TCGA−F4−6569−01 TCGA−DY−A1DF−01 TCGA−DY−A0XA−01 TCGA−DM−A28H−01 TCGA−DM−A1D9−01 TCGA−DM−A1D4−01 TCGA−DC−6681−01 TCGA−D5−6924−01 TCGA−D5−6534−01 TCGA−D5−6533−01 TCGA−D5−6532−01 TCGA−D5−5539−01 TCGA−CM−6680−01 TCGA−CM−6166−01 TCGA−CM−5868−01 TCGA−CM−5349−01 TCGA−CK−5915−01 TCGA−CK−5914−01 TCGA−CK−4950−01 TCGA−CA−6719−01 TCGA−CA−5796−01 TCGA−AZ−6599−01 TCGA−AG−A011−01 TCGA−AG−3732−01 TCGA−AF−6672−01 TCGA−AF−6136−01 TCGA−AA−3973−01 TCGA−AA−3821−01 TCGA−AA−3811−01 TCGA−AA−3660−01 TCGA−AA−3558−01 TCGA−A6−6652−01 TCGA−A6−6138−01 TCGA−A6−5664−01 TCGA−A6−5660−01 TCGA−A6−5659−01 TCGA−G4−6626−01 TCGA−G4−6299−01 TCGA−F5−6464−01 TCGA−F4−6855−01 TCGA−F4−6805−01 TCGA−EI−6508−01 TCGA−EI−6506−01 TCGA−DY−A1DD−01 TCGA−DM−A285−01 TCGA−DM−A1DB−01 TCGA−DM−A0XF−01 TCGA−DC−6155−01 TCGA−DC−5337−01 TCGA−D5−7000−01 TCGA−D5−6920−01 TCGA−D5−6898−01 TCGA−D5−6541−01 TCGA−CM−6172−01 TCGA−CM−6170−01 TCGA−CM−6165−01 TCGA−CM−6163−01 TCGA−CM−5860−01 TCGA−CA−6716−01 TCGA−AZ−6607−01 TCGA−AZ−6605−01 TCGA−AZ−6603−01 TCGA−AZ−5403−01 TCGA−AZ−4681−01 TCGA−AZ−4616−01 TCGA−AH−6547−01 TCGA−AG−A02X−01 TCGA−AG−A020−01 TCGA−AG−A016−01 TCGA−AG−A008−01 TCGA−AG−4005−01 TCGA−AG−3901−01 TCGA−AG−3887−01 TCGA−AG−3885−01 TCGA−AF−2693−01 TCGA−AD−6899−01 TCGA−AD−6888−01 TCGA−AA−A02O−01 TCGA−AA−A01D−01 TCGA−AA−A00K−01 TCGA−AA−3861−01 TCGA−AA−3697−01 TCGA−AA−3692−01 TCGA−AA−3530−01 TCGA−AA−3522−01 TCGA−AA−3496−01 TCGA−A6−6654−01 TCGA−A6−6651−01 TCGA−A6−6137−01 TCGA−A6−5656−01 TCGA−A6−2678−01

TCGA−CK−5913−01 TCGA−CL−5917−01 TCGA−AG−3605−01 TCGA−AA−3855−01 TCGA−AD−6889−01 TCGA−EI−6507−01 TCGA−AG−3883−01 TCGA−A6−5665−01 TCGA−AA−3710−01 TCGA−AA−3815−01 TCGA−DM−A1DA−01 TCGA−CK−4948−01 TCGA−AG−A036−01 TCGA−AG−3896−01 TCGA−AA−3831−01 TCGA−CA−6717−01 TCGA−AG−3892−01 TCGA−F4−6806−01 TCGA−D5−5541−01 TCGA−CK−6751−01 TCGA−AG−A02N−01 TCGA−AG−3598−01 TCGA−AA−A00R−01 TCGA−AA−A00J−01 TCGA−A6−6653−01 TCGA−AA−3492−01 TCGA−G4−6588−01 TCGA−DY−A1DC−01 TCGA−CK−4952−01 TCGA−D5−6931−01 TCGA−CM−6674−01 TCGA−CL−5918−01 TCGA−AA−A03F−01 TCGA−AA−A01R−01 TCGA−AA−A01Q−01 TCGA−AA−3514−01 TCGA−A6−6141−01 TCGA−A6−5661−01 TCGA−A6−3808−01 TCGA−AA−A029−01 TCGA−AA−A00N−01 TCGA−AA−3977−01 TCGA−AA−3663−01 TCGA−A6−6780−01 TCGA−G5−6235−01 TCGA−CM−6169−01 TCGA−CM−6168−01 TCGA−AG−A01W−01 TCGA−AG−3890−01 TCGA−AG−3608−01 TCGA−AA−A024−01 TCGA−AA−A01V−01 TCGA−AA−3842−01 TCGA−AA−3696−01 TCGA−AA−3684−01 TCGA−AA−A010−01 TCGA−AG−A002−01 TCGA−AA−3510−01 TCGA−AZ−4315−01 TCGA−CM−4743−01 TCGA−AZ−6608−01 TCGA−AY−5543−01 TCGA−EF−5830−01 TCGA−DM−A28E−01 TCGA−D5−6923−01 TCGA−CM−6676−01 TCGA−CM−6164−01 TCGA−CM−5862−01 TCGA−CK−4947−01 TCGA−AZ−5407−01 TCGA−AG−3742−01 TCGA−AF−2687−01 TCGA−AD−5900−01 TCGA−AA−3518−01 TCGA−AA−3511−01 TCGA−A6−5662−01 TCGA−A6−5657−01 TCGA−G4−6310−01 TCGA−AA−3864−01 TCGA−G4−6628−01 TCGA−DY−A0XA−01 TCGA−AZ−6600−01 TCGA−AD−6964−01 TCGA−AA−3984−01 TCGA−AA−3968−01 TCGA−AA−3662−01 TCGA−G4−6586−01 TCGA−G4−6323−01 TCGA−G4−6309−01 TCGA−G4−6303−01 TCGA−F5−6465−01 TCGA−F4−6460−01 TCGA−DY−A1DF−01 TCGA−DM−A28K−01 TCGA−DM−A1DB−01 TCGA−D5−6927−01 TCGA−D5−6533−01 TCGA−D5−5540−01 TCGA−CM−6172−01 TCGA−CM−6171−01 TCGA−CM−6161−01 TCGA−CM−5348−01 TCGA−CM−4752−01 TCGA−CA−6719−01 TCGA−CA−6718−01 TCGA−AZ−6603−01 TCGA−AZ−6601−01 TCGA−AZ−6599−01 TCGA−AZ−6598−01 TCGA−AY−6386−01 TCGA−AY−6197−01 TCGA−AG−A011−01 TCGA−AA−3660−01 TCGA−AA−3555−01 TCGA−AA−3520−01 TCGA−A6−6138−01 TCGA−A6−5660−01 TCGA−A6−3809−01 TCGA−G4−6626−01 TCGA−G4−6625−01 TCGA−G4−6317−01 TCGA−G4−6304−01 TCGA−G4−6299−01 TCGA−G4−6293−01 TCGA−F5−6812−01 TCGA−F5−6464−01 TCGA−F4−6855−01 TCGA−F4−6805−01 TCGA−F4−6570−01 TCGA−F4−6569−01 TCGA−EI−6508−01 TCGA−EI−6506−01 TCGA−DY−A1DG−01 TCGA−DY−A1DD−01 TCGA−DM−A28H−01 TCGA−DM−A285−01 TCGA−DM−A1D9−01 TCGA−DM−A1D8−01 TCGA−DM−A1D4−01 TCGA−DM−A0XF−01 TCGA−DC−6681−01 TCGA−DC−6155−01 TCGA−DC−5337−01 TCGA−D5−7000−01 TCGA−D5−6930−01 TCGA−D5−6928−01 TCGA−D5−6924−01 TCGA−D5−6920−01 TCGA−D5−6898−01 TCGA−D5−6541−01 TCGA−D5−6536−01 TCGA−D5−6534−01 TCGA−D5−6532−01 TCGA−D5−5539−01 TCGA−D5−5538−01 TCGA−CM−6680−01 TCGA−CM−6170−01 TCGA−CM−6166−01 TCGA−CM−6165−01 TCGA−CM−6163−01 TCGA−CM−5868−01 TCGA−CM−5861−01 TCGA−CM−5860−01 TCGA−CM−5349−01 TCGA−CM−5344−01 TCGA−CK−6746−01 TCGA−CK−5916−01 TCGA−CK−5915−01 TCGA−CK−5914−01 TCGA−CK−4950−01 TCGA−CA−6716−01 TCGA−CA−5796−01 TCGA−AZ−6607−01 TCGA−AZ−6605−01 TCGA−AZ−5403−01 TCGA−AZ−4681−01 TCGA−AZ−4616−01 TCGA−AY−6196−01 TCGA−AU−6004−01 TCGA−AU−3779−01 TCGA−AH−6547−01 TCGA−AG−A02X−01 TCGA−AG−A020−01 TCGA−AG−A016−01 TCGA−AG−A008−01 TCGA−AG−4005−01 TCGA−AG−3901−01 TCGA−AG−3887−01 TCGA−AG−3885−01 TCGA−AG−3732−01 TCGA−AF−6672−01 TCGA−AF−6136−01 TCGA−AF−2693−01 TCGA−AD−6899−01 TCGA−AD−6888−01 TCGA−AA−A02O−01 TCGA−AA−A01D−01 TCGA−AA−A00K−01 TCGA−AA−3973−01 TCGA−AA−3950−01 TCGA−AA−3861−01 TCGA−AA−3845−01 TCGA−AA−3821−01 TCGA−AA−3811−01 TCGA−AA−3713−01 TCGA−AA−3697−01 TCGA−AA−3692−01 TCGA−AA−3666−01 TCGA−AA−3558−01 TCGA−AA−3530−01 TCGA−AA−3522−01 TCGA−AA−3496−01 TCGA−A6−6654−01 TCGA−A6−6652−01 TCGA−A6−6651−01 TCGA−A6−6137−01 TCGA−A6−5664−01 TCGA−A6−5659−01 TCGA−A6−5656−01 TCGA−A6−2678−01 TCGA−A6−2676−01

GBM

GRB2:SOS Provides Linkage To MAPK Signaling For Integrins FDR = 3.7%, FDR nod = 3.9% Signaling By PDGF FDR = 0.0055%, FDR nod = 0.22%

TCGA−41−3393−01A−01D−1353−08 TCGA−28−2501−01A−01D−1696−08 TCGA−76−4927−01A−01D−1486−08 TCGA−81−5911−01A−12D−1845−08 TCGA−74−6575−01A−11D−1845−08 TCGA−32−1970−01A−01D−1494−08 TCGA−06−0126−01A−01D−1490−08 TCGA−06−0221−02A−11D−2280−08 TCGA−06−0154−01A−03D−1491−08 TCGA−32−4719−01A−01D−1353−08 TCGA−32−4213−01A−01D−1353−08 TCGA−12−5295−01A−01D−1486−08 TCGA−19−5952−01A−11D−1696−08 TCGA−19−2631−01A−01D−1353−08 TCGA−76−4929−01A−01D−1486−08 TCGA−41−6646−01A−11D−1845−08 TCGA−28−6450−01A−11D−1696−08 TCGA−76−6657−01A−11D−1845−08 TCGA−26−5134−01A−01D−1486−08

SRC

TCGA−16−0861−01A−01W−0424−08

ITGB3

TCGA−14−0789−01A−01W−0424−08

ITGA2B

TCGA−06−0881−01A−02W−0424−08

FGB

TCGA−02−0047−01A−01D−1490−08

APBB1IP

TCGA−27−1830−01A−01W−0643−08

wt

TCGA−19−1790−01B−01D−1353−08

FGG

TCGA−41−2571−01A−01D−1495−08

FN1

known HCG mut FGA

TCGA−16−1045−01B−01W−0611−08

unknown CG mut

TCGA−14−0790−01B−01D−1494−08

VWF

TCGA−12−0618−01A−01D−1492−08 TCGA−06−0157−01A−01D−1491−08

TCGA−14−0789−01A−01W−0424−08 TCGA−02−0047−01A−01D−1490−08 TCGA−74−6578−01A−11D−1845−08 TCGA−06−5414−01A−01D−1486−08 TCGA−32−4210−01A−01D−1353−08 TCGA−74−6575−01A−11D−1845−08 TCGA−41−5651−01A−01D−1696−08 TCGA−06−6391−01A−11D−1696−08 TCGA−06−0876−01A−01W−0424−08 TCGA−06−0168−01A−01D−1491−08 TCGA−26−5132−01A−01D−1486−08 TCGA−06−0240−01A−03D−1491−08 Br02X TCGA−76−6663−01A−11D−1845−08 TCGA−28−5220−01A−01D−1486−08 TCGA−06−0686−01A−01W−0348−08 TCGA−76−6191−01A−12D−1696−08 TCGA−19−5953−01B−12D−1845−08 TCGA−06−0877−01A−01W−0424−08 TCGA−12−5295−01A−01D−1486−08 TCGA−14−0813−01A−01W−0424−08 Br04X TCGA−74−6584−01A−11D−1845−08 TCGA−12−0821−01A−01W−0424−08 Br27P TCGA−19−5960−01A−11D−1696−08 TCGA−14−3476−01B−01D−1353−08 TCGA−06−0209−01A−01D−1491−08 TCGA−06−0158−01A−01D−1491−08 Br05X TCGA−32−2632−01A−01D−1495−08 TCGA−32−5222−01A−01D−1486−08 TCGA−16−1048−01B−01D−1353−08 TCGA−15−0742−01A−01W−0348−08 TCGA−06−0128−01A−01D−1490−08 TCGA−76−6661−01B−11D−1845−08 TCGA−76−4932−01A−01D−1486−08 TCGA−06−2564−01A−01D−1494−08 TCGA−06−0882−01A−01W−0424−08 TCGA−06−0645−01A−01D−1492−08 TCGA−32−4213−01A−01D−1353−08 TCGA−32−1982−01A−01D−1494−08 TCGA−27−1834−01A−01W−0643−08 TCGA−14−1034−02B−01D−2280−08 TCGA−06−0644−01A−02D−1492−08 TCGA−06−0142−01A−01D−1490−08 TCGA−19−2631−01A−01D−1353−08 TCGA−14−0740−01B−01D−1845−08 TCGA−19−1390−01A−01D−1495−08 TCGA−06−2559−01A−01D−1494−08 TCGA−06−0241−01A−02D−1491−08 TCGA−06−0214−01A−02D−1491−08 TCGA−06−0213−01A−01D−1491−08 TCGA−06−0174−01A−01D−1491−08 Br15X TCGA−27−1831−01A−01D−1494−08 TCGA−14−2554−01A−01D−1494−08 TCGA−06−0649−01B−01W−0348−08 TCGA−06−0171−02A−11D−2280−08 TCGA−76−4927−01A−01D−1486−08 TCGA−41−3915−01A−01D−1353−08 TCGA−28−5211−01C−11D−1845−08 TCGA−26−5136−01B−01D−1486−08 TCGA−19−5951−01A−11D−1696−08 TCGA−06−1804−01A−01D−1696−08 TCGA−06−0881−01A−02W−0424−08 TCGA−06−0743−01A−01D−1492−08 TCGA−06−0119−01A−08D−1490−08 TCGA−02−0055−01A−01D−1490−08

P130Cas Linkage To MAPK Signaling For Integrins FDR = 1.9%, FDR nod = 3.9%

wt wt COL6A6

FGG COL6A5

FN1 COL4A2

COL4A5

COL6A1

PDGFRB

APBB1IP

THBS1

SOS1 COL4A1

FGB

PDGFD

ITGA2B PLAT

COL4A3

ITGB3 COL9A1 PLG

THBS4

SRC

known HCG mut FGA known HCG mut COL6A2

unknown CG mut unknown CG mut COL6A3

PDGFRA

VWF

COL4A4

TCGA−41−3393−01A−01D−1353−08 TCGA−28−2501−01A−01D−1696−08 TCGA−76−4927−01A−01D−1486−08 TCGA−32−1970−01A−01D−1494−08 TCGA−06−0126−01A−01D−1490−08 TCGA−06−0221−02A−11D−2280−08 TCGA−06−0154−01A−03D−1491−08 TCGA−32−4719−01A−01D−1353−08 TCGA−32−4213−01A−01D−1353−08 TCGA−12−5295−01A−01D−1486−08 TCGA−19−5952−01A−11D−1696−08 TCGA−19−2631−01A−01D−1353−08 TCGA−76−4929−01A−01D−1486−08 TCGA−41−6646−01A−11D−1845−08 TCGA−28−6450−01A−11D−1696−08 TCGA−76−6657−01A−11D−1845−08 TCGA−26−5134−01A−01D−1486−08 TCGA−16−0861−01A−01W−0424−08 TCGA−14−0789−01A−01W−0424−08 TCGA−06−0881−01A−02W−0424−08 TCGA−02−0047−01A−01D−1490−08 TCGA−19−1790−01B−01D−1353−08 TCGA−41−2571−01A−01D−1495−08 TCGA−27−1830−01A−01W−0643−08 TCGA−16−1045−01B−01W−0611−08 TCGA−14−0790−01B−01D−1494−08 TCGA−12−0618−01A−01D−1492−08 TCGA−06−0157−01A−01D−1491−08

HSNC

HDACs Deacetylate Histones FDR = 0.00051%, FDR nod = 0.002% Activation Of Matrix Metalloproteinases FDR = 0.53%, FDR nod = 3.1%

PLG

PRSS1 KLKB1

MMP1 CMA1

CTRB2

MMP10

MMP14

MMP15

MMP17 MMP2

MMP25 MMP3

MMP7

MMP8

COL18A1 CTSG

FURIN

MMP24 TIMP1

TPSAB1

TCGA−BA−4075−01A−01D−1434−08 TCGA−CR−7364−01A−11D−2012−08 HN_62415−Tumor TCGA−CR−6470−01A−11D−1870−08 TCGA−CV−7263−01A−11D−2012−08 TCGA−CN−4739−01A−02D−1512−08 TCGA−IQ−7632−01A−11D−2078−08 TCGA−CV−7429−01A−11D−2129−08 TCGA−CV−7433−01A−11D−2129−08 TCGA−CV−5442−01A−01D−1512−08 TCGA−CQ−5324−01A−01D−1683−08 TCGA−CR−6488−01A−12D−2078−08 TCGA−CQ−6219−01A−11D−1912−08 HN_63080−Tumor TCGA−CQ−5332−01A−01D−1683−08 TCGA−CR−7377−01A−11D−2012−08 TCGA−CR−6472−01A−11D−1870−08 TCGA−CV−7245−01A−11D−2012−08 TCGA−CR−7401−01A−11D−2012−08 TCGA−CR−7365−01A−11D−2012−08 TCGA−CR−6478−01A−11D−1870−08 TCGA−CV−6962−01A−11D−1912−08 TCGA−CV−6951−01A−11D−1912−08 TCGA−CN−5369−01A−01D−1434−08 TCGA−CN−4740−01A−01D−1434−08 TCGA−CV−5439−01A−01D−1683−08 TCGA−CR−7380−01A−11D−2012−08 TCGA−BA−4074−01A−01D−1434−08 HN_62421−Tumor TCGA−CR−7367−01A−11D−2012−08 TCGA−CN−5356−01A−01D−1434−08 TCGA−CV−7414−01A−11D−2078−08 TCGA−CR−5248−01A−01D−2012−08 TCGA−CR−5243−01A−01D−1512−08 TCGA−CR−6484−01A−11D−1870−08 HN_62755−Tumor HN_62318−Tumor TCGA−CV−6436−01A−11D−1683−08 TCGA−CV−7248−01A−11D−2012−08 TCGA−CV−5430−01A−02D−1683−08 TCGA−CV−7255−01A−11D−2012−08 TCGA−CR−7385−01A−11D−2012−08 TCGA−CR−7368−01A−11D−2129−08 TCGA−CV−7089−01A−11D−2012−08 TCGA−CR−7399−01A−11D−2012−08 TCGA−CR−6480−01A−11D−1870−08 TCGA−CN−6992−01A−11D−1912−08 HN_62825−Tumor TCGA−CV−7250−01A−11D−2012−08 TCGA−CR−7371−01A−11D−2012−08 TCGA−CQ−6218−01A−11D−1912−08 TCGA−CV−7427−01A−11D−2078−08 TCGA−CV−7243−01A−11D−2012−08 TCGA−CV−7236−01A−11D−2012−08 TCGA−BB−4224−01A−01D−1434−08 TCGA−BA−5558−01A−01D−1512−08 HN_63021−Tumor TCGA−BB−4223−01A−01D−1434−08 TCGA−CV−6942−01A−21D−2012−08 TCGA−CR−7394−01A−11D−2012−08 HN_62646−Tumor TCGA−CV−7435−01A−11D−2129−08 TCGA−CV−7411−01A−11D−2078−08 TCGA−CV−6938−01A−11D−1912−08 TCGA−CV−6937−01A−11D−2012−08 TCGA−CR−5247−01A−01D−2012−08 HN_63081−Tumor HN_62506−Tumor

TCGA−CV−7406−01A−11D−2078−08 TCGA−CR−6480−01A−11D−1870−08 HN_62481−Tumor TCGA−CR−6488−01A−12D−2078−08 TCGA−CR−6472−01A−11D−1870−08 HN_62415−Tumor TCGA−CR−7367−01A−11D−2012−08 TCGA−CR−6470−01A−11D−1870−08 TCGA−IQ−7632−01A−11D−2078−08 TCGA−CV−7429−01A−11D−2129−08 TCGA−CR−7401−01A−11D−2012−08 TCGA−CR−7385−01A−11D−2012−08 TCGA−CN−5369−01A−01D−1434−08 HN_62426−Tumor TCGA−CQ−5325−01A−01D−1683−08 TCGA−CQ−5327−01A−01D−1683−08 TCGA−CV−5442−01A−01D−1512−08 TCGA−CQ−5324−01A−01D−1683−08 TCGA−CR−5248−01A−01D−2012−08 TCGA−CR−5243−01A−01D−1512−08 TCGA−CV−7427−01A−11D−2078−08 TCGA−CV−7243−01A−11D−2012−08 HN_63021−Tumor TCGA−BB−4223−01A−01D−1434−08 HN_62825−Tumor TCGA−CV−7250−01A−11D−2012−08 HN_62755−Tumor HN_62318−Tumor HN_62421−Tumor TCGA−CQ−5323−01A−01D−1683−08 TCGA−HD−7754−01A−11D−2078−08 TCGA−CR−7395−01A−11D−2012−08 TCGA−DQ−5625−01A−01D−1870−08 HN_62699−Tumor HN_62672−Tumor TCGA−CV−7411−01A−11D−2078−08 TCGA−CV−6938−01A−11D−1912−08 TCGA−CR−5247−01A−01D−2012−08 TCGA−CV−7433−01A−11D−2129−08 TCGA−CV−7255−01A−11D−2012−08 TCGA−CV−7245−01A−11D−2012−08 TCGA−CV−6962−01A−11D−1912−08 TCGA−CV−6934−01A−11D−1912−08 TCGA−CV−6436−01A−11D−1683−08 TCGA−CR−7394−01A−11D−2012−08 TCGA−CR−7380−01A−11D−2012−08 TCGA−CR−7377−01A−11D−2012−08 TCGA−CR−6484−01A−11D−1870−08 TCGA−CN−6992−01A−11D−1912−08 TCGA−CN−5373−01A−01D−1434−08 TCGA−CN−5356−01A−01D−1434−08 TCGA−BA−4076−01A−01D−1434−08 HN_63081−Tumor HN_63080−Tumor HN_62646−Tumor TCGA−HD−7229−01A−11D−2012−08 TCGA−DQ−5629−01A−01D−1870−08 TCGA−D6−6826−01A−11D−1912−08 TCGA−CX−7219−01A−11D−2012−08 TCGA−CX−7082−01A−11D−2012−08 TCGA−CV−7435−01A−11D−2129−08 TCGA−CV−7414−01A−11D−2078−08 TCGA−CV−7263−01A−11D−2012−08 TCGA−CV−7252−01A−11D−2012−08 TCGA−CV−7248−01A−11D−2012−08 TCGA−CV−7236−01A−11D−2012−08 TCGA−CV−7102−01A−11D−2012−08 TCGA−CV−7089−01A−11D−2012−08 TCGA−CV−6952−01A−11D−1912−08 TCGA−CV−6951−01A−11D−1912−08 TCGA−CV−6950−01A−11D−1912−08 TCGA−CV−6942−01A−21D−2012−08 TCGA−CV−6937−01A−11D−2012−08 TCGA−CV−5439−01A−01D−1683−08 TCGA−CV−5430−01A−02D−1683−08 TCGA−CR−7399−01A−11D−2012−08 TCGA−CR−7386−01A−11D−2012−08 TCGA−CR−7371−01A−11D−2012−08 TCGA−CR−7368−01A−11D−2129−08 TCGA−CR−7365−01A−11D−2012−08 TCGA−CR−7364−01A−11D−2012−08 TCGA−CR−6491−01A−11D−1870−08 TCGA−CR−6478−01A−11D−1870−08 TCGA−CR−6474−01A−11D−1870−08 TCGA−CQ−6224−01A−11D−1912−08 TCGA−CQ−6220−01A−11D−1912−08 TCGA−CQ−6219−01A−11D−1912−08 TCGA−CQ−6218−01A−11D−1912−08 TCGA−CQ−5334−01A−01D−1683−08 TCGA−CQ−5332−01A−01D−1683−08 TCGA−CN−6997−01A−11D−2012−08 TCGA−CN−6024−01A−11D−1683−08 TCGA−CN−6023−01A−11D−1683−08 TCGA−CN−5364−01A−01D−1434−08 TCGA−CN−4740−01A−01D−1434−08 TCGA−CN−4739−01A−02D−1512−08 TCGA−BB−4224−01A−01D−1434−08 TCGA−BA−5558−01A−01D−1512−08 TCGA−BA−4075−01A−01D−1434−08 TCGA−BA−4074−01A−01D−1434−08 HN_62652−Tumor HN_62506−Tumor HN_62432−Tumor TCGA−IQ−7630−01A−11D−2078−08 TCGA−HD−7917−01A−11D−2229−08 TCGA−HD−7831−01A−11D−2129−08 TCGA−F7−7848−01A−11D−2129−08 TCGA−DQ−7595−01A−11D−2229−08 TCGA−DQ−7592−01A−11D−2078−08 TCGA−DQ−7588−01A−11D−2078−08 TCGA−DQ−5631−01A−01D−1870−08 TCGA−DQ−5630−01A−01D−1870−08 TCGA−DQ−5624−01A−01D−1870−08 TCGA−D6−6825−01A−21D−1912−08 TCGA−D6−6824−01A−11D−1912−08 TCGA−D6−6823−01A−11D−1912−08 TCGA−D6−6517−01A−11D−1870−08 TCGA−D6−6515−01A−21D−1870−08 TCGA−CX−7086−01A−11D−2078−08 TCGA−CV−7438−01A−21D−2129−08 TCGA−CV−7437−01A−21D−2129−08 TCGA−CV−7434−01A−11D−2129−08 TCGA−CV−7432−01A−11D−2129−08 TCGA−CV−7430−01A−11D−2129−08 TCGA−CV−7424−01A−11D−2078−08 TCGA−CV−7422−01A−21D−2078−08 TCGA−CV−7421−01A−11D−2078−08 TCGA−CV−7418−01A−11D−2078−08 TCGA−CV−7416−01A−11D−2078−08 TCGA−CV−7415−01A−11D−2078−08 TCGA−CV−7413−01A−11D−2078−08 TCGA−CV−7409−01A−31D−2229−08 TCGA−CV−7254−01A−11D−2012−08 TCGA−CV−7253−01A−11D−2012−08 TCGA−CV−7247−01A−11D−2012−08 TCGA−CV−7242−01A−11D−2012−08 TCGA−CV−7238−01A−11D−2012−08 TCGA−CV−7235−01A−11D−2012−08 TCGA−CV−7180−01A−11D−2012−08 TCGA−CV−7177−01A−11D−2012−08 TCGA−CV−7104−01A−11D−2012−08 TCGA−CV−7103−01A−21D−2012−08 TCGA−CV−7101−01A−11D−2012−08 TCGA−CV−7099−01A−41D−2012−08 TCGA−CV−7097−01A−11D−2012−08 TCGA−CV−7095−01A−21D−2012−08 TCGA−CV−7091−01A−11D−2012−08 TCGA−CV−7090−01A−11D−2012−08 TCGA−CV−6960−01A−41D−2012−08 TCGA−CV−6959−01A−11D−1912−08 TCGA−CV−6956−01A−21D−2012−08 TCGA−CV−6953−01A−11D−1912−08 TCGA−CV−6948−01A−11D−1912−08 TCGA−CV−6945−01A−11D−1912−08 TCGA−CV−6943−01A−11D−1912−08 TCGA−CV−6940−01A−11D−1912−08 TCGA−CV−6936−01A−11D−1912−08 TCGA−CV−6935−01A−11D−1912−08 TCGA−CV−6933−01A−11D−1912−08 TCGA−CV−6003−01A−11D−1683−08 TCGA−CV−5979−01A−11D−1683−08 TCGA−CV−5978−01A−11D−1683−08 TCGA−CV−5977−01A−11D−1683−08 TCGA−CV−5976−01A−11D−1683−08 TCGA−CV−5973−01A−11D−1683−08 TCGA−CV−5970−01A−11D−1683−08 TCGA−CV−5966−01A−11D−1683−08 TCGA−CV−5444−01A−02D−1512−08 TCGA−CV−5440−01A−01D−1512−08 TCGA−CV−5436−01A−01D−1512−08 TCGA−CV−5435−01A−01D−1683−08 TCGA−CV−5434−01A−01D−1683−08 TCGA−CV−5432−01A−02D−1683−08 TCGA−CV−5431−01A−01D−1512−08 TCGA−CR−7398−01A−11D−2012−08 TCGA−CR−7397−01A−11D−2012−08 TCGA−CR−7393−01A−11D−2012−08 TCGA−CR−7390−01A−11D−2012−08 TCGA−CR−7389−01A−11D−2012−08 TCGA−CR−7383−01A−11D−2129−08 TCGA−CR−7379−01A−11D−2012−08 TCGA−CR−7376−01A−11D−2129−08 TCGA−CR−7374−01A−11D−2012−08 TCGA−CR−7372−01A−11D−2012−08 TCGA−CR−7370−01A−11D−2129−08 TCGA−CR−6493−01A−11D−1870−08 TCGA−CR−6477−01A−11D−1870−08 TCGA−CQ−7067−01A−11D−2229−08 TCGA−CQ−7065−01A−11D−2078−08 TCGA−CQ−6229−01A−11D−1912−08 TCGA−CQ−6228−01A−11D−1912−08 TCGA−CQ−6225−01A−11D−1912−08 TCGA−CQ−6223−01A−11D−1912−08 TCGA−CQ−6222−01A−11D−1912−08 TCGA−CQ−6221−01A−11D−2078−08 TCGA−CQ−5331−01A−02D−1870−08 TCGA−CQ−5330−01A−01D−1683−08 TCGA−CQ−5329−01A−01D−1683−08 TCGA−CQ−5326−01A−01D−1870−08 TCGA−CN−6998−01A−23D−2012−08 TCGA−CN−6996−01A−11D−1912−08 TCGA−CN−6995−01A−31D−2012−08 TCGA−CN−6994−01A−11D−1912−08 TCGA−CN−6989−01A−11D−1912−08 TCGA−CN−6988−01A−11D−1912−08 TCGA−CN−6022−01A−21D−1683−08 TCGA−CN−6021−01A−11D−1683−08 TCGA−CN−6020−01A−11D−1683−08 TCGA−CN−6019−01A−11D−1683−08 TCGA−CN−6018−01A−11D−1683−08 TCGA−CN−6017−01A−11D−1683−08 TCGA−CN−6016−01A−11D−1683−08 TCGA−CN−6013−01A−11D−1683−08 TCGA−CN−6012−01A−11D−1683−08 TCGA−CN−6011−01A−11D−1683−08 TCGA−CN−5370−01A−01D−2012−08 TCGA−CN−5367−01A−01D−1434−08 TCGA−CN−5366−01A−01D−1434−08 TCGA−CN−5365−01A−01D−1434−08 TCGA−CN−5363−01A−01D−1434−08 TCGA−CN−5360−01A−01D−1434−08 TCGA−CN−5359−01A−01D−1434−08 TCGA−CN−4742−01A−02D−1512−08 TCGA−CN−4738−01A−02D−1512−08 TCGA−CN−4737−01A−01D−1434−08 TCGA−CN−4736−01A−01D−1434−08 TCGA−CN−4735−01A−01D−1434−08 TCGA−CN−4733−01A−02D−1870−08 TCGA−CN−4731−01A−01D−1434−08 TCGA−CN−4729−01A−01D−1434−08 TCGA−CN−4728−01A−01D−1434−08 TCGA−CN−4727−01A−01D−1434−08 TCGA−CN−4726−01A−01D−1434−08 TCGA−CN−4725−01A−01D−1434−08 TCGA−BB−7871−01A−11D−2229−08 TCGA−BB−7870−01A−11D−2229−08 TCGA−BB−7862−01A−21D−2229−08 TCGA−BB−4227−01A−01D−1870−08 TCGA−BB−4217−01A−11D−2078−08 TCGA−BA−7269−01A−11D−2012−08 TCGA−BA−6873−01A−11D−1870−08 TCGA−BA−6872−01A−11D−1870−08 TCGA−BA−6870−01A−11D−1870−08 TCGA−BA−6869−01A−11D−1870−08 TCGA−BA−6868−01B−12D−1912−08 TCGA−BA−5557−01A−01D−1512−08 TCGA−BA−5555−01A−01D−1512−08 TCGA−BA−5152−01A−02D−1870−08 TCGA−BA−5151−01A−01D−1434−08 TCGA−BA−4078−01A−01D−1434−08 HN_63114−Tumor HN_63058−Tumor HN_63048−Tumor HN_63039−Tumor HN_63007−Tumor HN_62995−Tumor HN_62984−Tumor HN_62926−Tumor HN_62921−Tumor HN_62897−Tumor HN_62857_2−Tumor HN_62832−Tumor HN_62814−Tumor HN_62741−Tumor HN_62739−Tumor HN_62671−Tumor HN_62601−Tumor HN_62539−Tumor HN_62532−Tumor HN_62515−Tumor HN_62505−Tumor HN_62493−Tumor HN_62469−Tumor HN_62376−Tumor HN_62338−Tumor HN_62332−Tumor HN_62298−Tumor HN_01000−Tumor HN_00443−Tumor HN_00378−Tumor HN_00313−Tumor HN_00190−Tumor HN_0−046−Tumor

DNA Damage/Telomere Stress Induced Senescence FDR = 2e−12%, FDR nod = 4e−04%

known HCG mut

wt

wt wt

known HCG mut

wt

TP53 HERC2 TP53BP1 BRIP1 CLSPN WHSC1 ATM ATR CCNA1 HIST1H2BF HIST1H2BK HIST1H4E HIST1H4H NBN WRN ATRIP BLM BRCA1 CHEK1 HIST1H2BG HIST1H2BI HIST1H2BL HIST1H2BM HIST1H4C HIST4H4 MRE11A RAD50 BARD1 BRE CCNA2 CHEK2 DNA2 EXO1 FAM175A HIST1H2BB HIST1H2BD HIST1H2BE HIST1H2BH HIST1H2BJ HIST1H2BN HIST1H4B HIST1H4D HIST1H4F HIST1H4I HIST1H4K HIST1H4L HIST2H2BE HUS1 KAT5 MDC1 PIAS4 PPP4C RAD17 RBBP8 RFC2 RFC4 RFC5 RMI1 RNF168 RPA1 RPS27A SIRT6 TIMELESS TOP3A TOPBP1 UBA52 UBC UBE2I UIMC1

unknown CG mut

unknown CG mut

TP53 HIST1H4E NBN ATM CCNA1 HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BK HIST1H4C TINF2 CCNE2 CDKN1B EP400 H2AFZ HIST1H2AB HIST1H2BI HIST1H2BL HIST1H2BM HIST1H4D HIST1H4F HIST1H4H HIST2H2AC HIST4H4 MRE11A POT1 ACD CCNA2 CCNE1 HIST1H2AC HIST1H2AE HIST1H2AJ HIST1H2BB HIST1H2BD HIST1H2BE HIST1H2BJ HIST1H2BN HIST1H4B HIST1H4I HIST1H4K HIST1H4L HIST2H2BE KAT5 RAD50 TERF1 TERF2



wt wt

unknown CG mut HIST1H4E HIST1H2BH HIST1H2BK HIST1H2BG POT1 HIST1H2AB HIST1H2BD HIST1H2BF HIST1H4C HIST1H4F TERF1 HIST1H2AC HIST1H2AE HIST1H2BB HIST1H2BI HIST2H2AC HIST2H2BE HIST4H4 TINF2 ACD HIST1H2BL HIST1H2BM HIST1H2BN HIST1H4B HIST1H4D HIST1H4H HIST1H4K H2AFZ HIST1H2AJ HIST1H2BE HIST1H2BJ HIST1H4I HIST1H4L TERF2 unknown CG mut

TP53 HIST1H4E NBN ATM CCNA1 HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BK HIST1H4C TINF2 CCNE2 CDKN1B EP400 H2AFZ HIST1H2AB HIST1H2BI HIST1H2BL HIST1H2BM HIST1H4D HIST1H4F HIST1H4H HIST2H2AC HIST4H4 MRE11A POT1 ACD CCNA2 CCNE1 HIST1H2AC HIST1H2AE HIST1H2AJ HIST1H2BB HIST1H2BD HIST1H2BE HIST1H2BJ HIST1H2BN HIST1H4B HIST1H4I HIST1H4K HIST1H4L HIST2H2BE KAT5 RAD50 TERF1 TERF2

known HCG mut known HCG mut MMP16

TCGA−CR−6487−01A−11D−1870−08 TCGA−CV−6952−01A−11D−1912−08 TCGA−CR−7380−01A−11D−2012−08 TCGA−CN−4734−01A−01D−1434−08 HN_62338−Tumor TCGA−CX−7085−01A−21D−2012−08 HN_62415−Tumor TCGA−CN−5356−01A−01D−1434−08 TCGA−CR−6470−01A−11D−1870−08 TCGA−CN−6995−01A−31D−2012−08 TCGA−CQ−6225−01A−11D−1912−08 HN_62298−Tumor TCGA−CN−4739−01A−02D−1512−08 TCGA−IQ−7632−01A−11D−2078−08 TCGA−CV−7429−01A−11D−2129−08 TCGA−CR−7401−01A−11D−2012−08 TCGA−CR−7377−01A−11D−2012−08 TCGA−CR−6478−01A−11D−1870−08 TCGA−CV−5966−01A−11D−1683−08 TCGA−BA−5149−01A−01D−1512−08 TCGA−CV−7102−01A−11D−2012−08 HN_62860−Tumor TCGA−CQ−6220−01A−11D−1912−08 TCGA−H7−7774−01A−21D−2078−08 TCGA−CN−4736−01A−01D−1434−08 TCGA−CV−7254−01A−11D−2012−08 TCGA−CN−4735−01A−01D−1434−08 TCGA−CV−7104−01A−11D−2012−08 HN_63058−Tumor TCGA−HD−7229−01A−11D−2012−08 TCGA−CR−7395−01A−11D−2012−08 TCGA−CR−6488−01A−12D−2078−08 TCGA−CQ−6219−01A−11D−1912−08 HN_63080−Tumor TCGA−CQ−5332−01A−01D−1683−08 TCGA−CR−5248−01A−01D−2012−08 TCGA−CR−5243−01A−01D−1512−08 TCGA−CV−5441−01A−01D−1512−08 TCGA−CQ−5334−01A−01D−1683−08 TCGA−CV−5978−01A−11D−1683−08 HN_00190−Tumor TCGA−CV−6954−01A−11D−1912−08 TCGA−CN−6011−01A−11D−1683−08 HN_62755−Tumor HN_62318−Tumor TCGA−CR−6491−01A−11D−1870−08 TCGA−CN−6998−01A−23D−2012−08 TCGA−CV−7101−01A−11D−2012−08 TCGA−CN−6013−01A−11D−1683−08 TCGA−CV−6962−01A−11D−1912−08 TCGA−CV−6951−01A−11D−1912−08 TCGA−CN−4740−01A−01D−1434−08 TCGA−CN−5369−01A−01D−1434−08 TCGA−CV−7409−01A−31D−2229−08 TCGA−CN−5370−01A−01D−2012−08 TCGA−CN−6010−01A−11D−1683−08 TCGA−BA−4078−01A−01D−1434−08 TCGA−BB−7871−01A−11D−2229−08 TCGA−CV−6955−01A−11D−2012−08 TCGA−CR−7376−01A−11D−2129−08 TCGA−CR−7365−01A−11D−2012−08 TCGA−BA−5152−01A−02D−1870−08 TCGA−CX−7086−01A−11D−2078−08 TCGA−CV−7422−01A−21D−2078−08 TCGA−CV−7183−01A−11D−2012−08 TCGA−CN−5359−01A−01D−1434−08 TCGA−CV−7243−01A−11D−2012−08 TCGA−CV−7236−01A−11D−2012−08 TCGA−BB−4224−01A−01D−1434−08 TCGA−CV−6436−01A−11D−1683−08 TCGA−CV−7248−01A−11D−2012−08 TCGA−CV−5430−01A−02D−1683−08 TCGA−CV−7255−01A−11D−2012−08 TCGA−CR−7385−01A−11D−2012−08 TCGA−CR−7368−01A−11D−2129−08 TCGA−CV−6961−01A−21D−1912−08 TCGA−CR−7374−01A−11D−2012−08 TCGA−CN−5360−01A−01D−1434−08 HN_62505−Tumor TCGA−CQ−6218−01A−11D−1912−08 HN_62825−Tumor TCGA−CV−7250−01A−11D−2012−08 TCGA−CR−7371−01A−11D−2012−08 TCGA−CN−4730−01A−01D−1434−08 TCGA−CV−7423−01A−11D−2078−08 TCGA−CR−6472−01A−11D−1870−08 HN_62624−Tumor HN_62426−Tumor TCGA−CV−7263−01A−11D−2012−08 TCGA−CR−7367−01A−11D−2012−08 HN_62814−Tumor TCGA−CQ−5326−01A−01D−1870−08 TCGA−CN−5374−01A−01D−1434−08 HN_63021−Tumor TCGA−BB−4223−01A−01D−1434−08 TCGA−CV−6942−01A−21D−2012−08 TCGA−CR−7394−01A−11D−2012−08 HN_62646−Tumor TCGA−CN−4727−01A−01D−1434−08 TCGA−BA−5558−01A−01D−1512−08 TCGA−CV−7099−01A−41D−2012−08 TCGA−CV−5970−01A−11D−1683−08 TCGA−BA−4074−01A−01D−1434−08 TCGA−CV−6938−01A−11D−1912−08 TCGA−CR−5247−01A−01D−2012−08 TCGA−CV−7435−01A−11D−2129−08 TCGA−CV−7411−01A−11D−2078−08 TCGA−CV−6937−01A−11D−2012−08 HN_63081−Tumor HN_62506−Tumor TCGA−CR−6484−01A−11D−1870−08 TCGA−DQ−5630−01A−01D−1870−08 TCGA−CN−6016−01A−11D−1683−08 TCGA−CN−5373−01A−01D−1434−08 TCGA−CV−6936−01A−11D−1912−08 TCGA−CR−7370−01A−11D−2129−08 TCGA−CN−6024−01A−11D−1683−08 TCGA−BA−4077−01B−01D−1434−08 HN_62421−Tumor TCGA−CR−7364−01A−11D−2012−08 TCGA−CV−7089−01A−11D−2012−08 TCGA−CV−5442−01A−01D−1512−08 TCGA−BB−7862−01A−21D−2229−08 TCGA−D6−6823−01A−11D−1912−08 TCGA−CR−7399−01A−11D−2012−08 TCGA−CR−7379−01A−11D−2012−08 TCGA−BA−6868−01B−12D−1912−08 HN_62739−Tumor TCGA−CR−6481−01A−11D−1870−08 TCGA−CV−7427−01A−11D−2078−08 TCGA−CV−6441−01A−11D−1683−08 TCGA−CV−7414−01A−11D−2078−08 TCGA−CV−7245−01A−11D−2012−08 HN_62854−Tumor TCGA−CV−7407−01A−11D−2078−08 TCGA−CV−7252−01A−11D−2012−08 TCGA−CV−5444−01A−02D−1512−08 TCGA−CQ−5331−01A−02D−1870−08 TCGA−CN−6992−01A−11D−1912−08 HN_62699−Tumor HN_01000−Tumor HN_00761−Tumor

TCGA−IQ−7631−01A−11D−2078−08 TCGA−CV−6945−01A−11D−1912−08 TCGA−CR−7368−01A−11D−2129−08 TCGA−CN−4740−01A−01D−1434−08 HN_62624−Tumor TCGA−CR−7399−01A−11D−2012−08 TCGA−BA−6870−01A−11D−1870−08 TCGA−CR−6492−01A−12D−2078−08 HN_62756−Tumor TCGA−BB−4223−01A−01D−1434−08 HN_00190−Tumor TCGA−CR−7380−01A−11D−2012−08 TCGA−CR−6491−01A−11D−1870−08 TCGA−CV−7177−01A−11D−2012−08 TCGA−CN−6023−01A−11D−1683−08 TCGA−CV−7406−01A−11D−2078−08 TCGA−CQ−6218−01A−11D−1912−08 TCGA−CV−7255−01A−11D−2012−08 TCGA−CV−7243−01A−11D−2012−08 TCGA−CV−7415−01A−11D−2078−08 TCGA−CV−7414−01A−11D−2078−08 TCGA−CN−5360−01A−01D−1434−08 TCGA−BA−6869−01A−11D−1870−08 TCGA−CV−7245−01A−11D−2012−08 TCGA−CR−7373−01A−11D−2012−08 TCGA−CR−7367−01A−11D−2012−08 TCGA−CN−5374−01A−01D−1434−08 TCGA−DQ−7589−01A−11D−2229−08 TCGA−BB−4227−01A−01D−1870−08 TCGA−CV−7235−01A−11D−2012−08 TCGA−CV−6940−01A−11D−1912−08 HN_63095−Tumor TCGA−BB−7862−01A−21D−2229−08 TCGA−CR−6487−01A−11D−1870−08 TCGA−BA−6872−01A−11D−1870−08 HN_62921−Tumor HN_62506−Tumor HN_62421−Tumor TCGA−F7−7848−01A−11D−2129−08 TCGA−HD−7753−01A−11D−2078−08 TCGA−CV−7261−01A−11D−2012−08 TCGA−CQ−5324−01A−01D−1683−08 HN_63021−Tumor HN_62415−Tumor TCGA−CV−7178−01A−21D−2012−08 TCGA−CV−7425−01A−11D−2078−08 TCGA−CV−7409−01A−31D−2229−08 TCGA−CV−6952−01A−11D−1912−08 TCGA−CR−7370−01A−11D−2129−08 TCGA−CR−6484−01A−11D−1870−08 TCGA−CR−6478−01A−11D−1870−08 TCGA−CQ−5329−01A−01D−1683−08 TCGA−BA−4078−01A−01D−1434−08 TCGA−CV−7433−01A−11D−2129−08 TCGA−CV−6961−01A−21D−1912−08 TCGA−CV−6954−01A−11D−1912−08 TCGA−CR−7364−01A−11D−2012−08 TCGA−BB−4228−01A−01D−1434−08 TCGA−BA−4077−01B−01D−1434−08 HN_62814−Tumor

Packaging Of Telomere Ends FDR = 1.2e−07%, FDR nod = 1.1e−06% DNA Damage/Telomere Stress Induced Senescence FDR = 2e−12%, FDR nod = 4e−04%

unknown CG mut NCOR1 NCOR2 CHD3 HIST1H4E CHD4 HIST1H2BH HIST1H3I MTA2 HIST1H2BG RCOR1 HIST1H2AB HIST1H2BD HIST1H2BK HIST1H3G HIST2H3D RBBP7 ARID4B GATAD2B HIST1H2AC HIST1H2AE HIST1H2AK HIST1H2AL HIST1H2BF HIST1H3E HIST1H3H HIST1H3J HIST1H4C HIST2H2BE HIST4H4 MTA1 PHF21A REST BRMS1 GPS2 HDAC10 HDAC3 HDAC8 HIST1H2AA HIST1H2AH HIST1H2BB HIST1H2BE HIST1H2BI HIST1H2BL HIST1H2BM HIST1H2BN HIST1H3A HIST1H3C HIST1H3D HIST1H4D HIST1H4F HIST1H4H HIST2H2BF MBD3 MTA3 SUDS3 TBL1X ARID4A GATAD2A HIST1H2AI HIST1H2AJ HIST1H2BJ HIST1H3B HIST1H4B HIST1H4I HIST1H4K HIST1H4L HIST2H2AB HIST2H2AC TBL1XR1 unknown CG mut

TCGA−CV−7406−01A−11D−2078−08 TCGA−CR−6480−01A−11D−1870−08 HN_62481−Tumor TCGA−CR−6488−01A−12D−2078−08 TCGA−CR−6472−01A−11D−1870−08 HN_62415−Tumor TCGA−CR−7367−01A−11D−2012−08 TCGA−CR−6470−01A−11D−1870−08 TCGA−IQ−7632−01A−11D−2078−08 TCGA−CV−7429−01A−11D−2129−08 TCGA−CR−7401−01A−11D−2012−08 TCGA−CR−7385−01A−11D−2012−08 TCGA−CN−5369−01A−01D−1434−08 HN_62426−Tumor TCGA−CQ−5325−01A−01D−1683−08 TCGA−CQ−5327−01A−01D−1683−08 TCGA−CV−5442−01A−01D−1512−08 TCGA−CQ−5324−01A−01D−1683−08 TCGA−CR−5248−01A−01D−2012−08 TCGA−CR−5243−01A−01D−1512−08 TCGA−CV−7427−01A−11D−2078−08 TCGA−CV−7243−01A−11D−2012−08 HN_63021−Tumor TCGA−BB−4223−01A−01D−1434−08 HN_62825−Tumor TCGA−CV−7250−01A−11D−2012−08 HN_62755−Tumor HN_62318−Tumor HN_62421−Tumor TCGA−CQ−5323−01A−01D−1683−08 TCGA−HD−7754−01A−11D−2078−08 TCGA−CR−7395−01A−11D−2012−08 TCGA−DQ−5625−01A−01D−1870−08 HN_62699−Tumor HN_62672−Tumor TCGA−CV−7411−01A−11D−2078−08 TCGA−CV−6938−01A−11D−1912−08 TCGA−CR−5247−01A−01D−2012−08 TCGA−CV−7433−01A−11D−2129−08 TCGA−CV−7255−01A−11D−2012−08 TCGA−CV−7245−01A−11D−2012−08 TCGA−CV−6962−01A−11D−1912−08 TCGA−CV−6934−01A−11D−1912−08 TCGA−CV−6436−01A−11D−1683−08 TCGA−CR−7394−01A−11D−2012−08 TCGA−CR−7380−01A−11D−2012−08 TCGA−CR−7377−01A−11D−2012−08 TCGA−CR−6484−01A−11D−1870−08 TCGA−CN−6992−01A−11D−1912−08 TCGA−CN−5373−01A−01D−1434−08 TCGA−CN−5356−01A−01D−1434−08 TCGA−BA−4076−01A−01D−1434−08 HN_63081−Tumor HN_63080−Tumor HN_62646−Tumor TCGA−HD−7229−01A−11D−2012−08 TCGA−DQ−5629−01A−01D−1870−08 TCGA−D6−6826−01A−11D−1912−08 TCGA−CX−7219−01A−11D−2012−08 TCGA−CX−7082−01A−11D−2012−08 TCGA−CV−7435−01A−11D−2129−08 TCGA−CV−7414−01A−11D−2078−08 TCGA−CV−7263−01A−11D−2012−08 TCGA−CV−7252−01A−11D−2012−08 TCGA−CV−7248−01A−11D−2012−08 TCGA−CV−7236−01A−11D−2012−08 TCGA−CV−7102−01A−11D−2012−08 TCGA−CV−7089−01A−11D−2012−08 TCGA−CV−6952−01A−11D−1912−08 TCGA−CV−6951−01A−11D−1912−08 TCGA−CV−6950−01A−11D−1912−08 TCGA−CV−6942−01A−21D−2012−08 TCGA−CV−6937−01A−11D−2012−08 TCGA−CV−5439−01A−01D−1683−08 TCGA−CV−5430−01A−02D−1683−08 TCGA−CR−7399−01A−11D−2012−08 TCGA−CR−7386−01A−11D−2012−08 TCGA−CR−7371−01A−11D−2012−08 TCGA−CR−7368−01A−11D−2129−08 TCGA−CR−7365−01A−11D−2012−08 TCGA−CR−7364−01A−11D−2012−08 TCGA−CR−6491−01A−11D−1870−08 TCGA−CR−6478−01A−11D−1870−08 TCGA−CR−6474−01A−11D−1870−08 TCGA−CQ−6224−01A−11D−1912−08 TCGA−CQ−6220−01A−11D−1912−08 TCGA−CQ−6219−01A−11D−1912−08 TCGA−CQ−6218−01A−11D−1912−08 TCGA−CQ−5334−01A−01D−1683−08 TCGA−CQ−5332−01A−01D−1683−08 TCGA−CN−6997−01A−11D−2012−08 TCGA−CN−6024−01A−11D−1683−08 TCGA−CN−6023−01A−11D−1683−08 TCGA−CN−5364−01A−01D−1434−08 TCGA−CN−4740−01A−01D−1434−08 TCGA−CN−4739−01A−02D−1512−08 TCGA−BB−4224−01A−01D−1434−08 TCGA−BA−5558−01A−01D−1512−08 TCGA−BA−4075−01A−01D−1434−08 TCGA−BA−4074−01A−01D−1434−08 HN_62652−Tumor HN_62506−Tumor HN_62432−Tumor TCGA−IQ−7630−01A−11D−2078−08 TCGA−HD−7917−01A−11D−2229−08 TCGA−HD−7831−01A−11D−2129−08 TCGA−F7−7848−01A−11D−2129−08 TCGA−DQ−7595−01A−11D−2229−08 TCGA−DQ−7592−01A−11D−2078−08 TCGA−DQ−7588−01A−11D−2078−08 TCGA−DQ−5631−01A−01D−1870−08 TCGA−DQ−5630−01A−01D−1870−08 TCGA−DQ−5624−01A−01D−1870−08 TCGA−D6−6825−01A−21D−1912−08 TCGA−D6−6824−01A−11D−1912−08 TCGA−D6−6823−01A−11D−1912−08 TCGA−D6−6517−01A−11D−1870−08 TCGA−D6−6515−01A−21D−1870−08 TCGA−CX−7086−01A−11D−2078−08 TCGA−CV−7438−01A−21D−2129−08 TCGA−CV−7437−01A−21D−2129−08 TCGA−CV−7434−01A−11D−2129−08 TCGA−CV−7432−01A−11D−2129−08 TCGA−CV−7430−01A−11D−2129−08 TCGA−CV−7424−01A−11D−2078−08 TCGA−CV−7422−01A−21D−2078−08 TCGA−CV−7421−01A−11D−2078−08 TCGA−CV−7418−01A−11D−2078−08 TCGA−CV−7416−01A−11D−2078−08 TCGA−CV−7415−01A−11D−2078−08 TCGA−CV−7413−01A−11D−2078−08 TCGA−CV−7409−01A−31D−2229−08 TCGA−CV−7254−01A−11D−2012−08 TCGA−CV−7253−01A−11D−2012−08 TCGA−CV−7247−01A−11D−2012−08 TCGA−CV−7242−01A−11D−2012−08 TCGA−CV−7238−01A−11D−2012−08 TCGA−CV−7235−01A−11D−2012−08 TCGA−CV−7180−01A−11D−2012−08 TCGA−CV−7177−01A−11D−2012−08 TCGA−CV−7104−01A−11D−2012−08 TCGA−CV−7103−01A−21D−2012−08 TCGA−CV−7101−01A−11D−2012−08 TCGA−CV−7099−01A−41D−2012−08 TCGA−CV−7097−01A−11D−2012−08 TCGA−CV−7095−01A−21D−2012−08 TCGA−CV−7091−01A−11D−2012−08 TCGA−CV−7090−01A−11D−2012−08 TCGA−CV−6960−01A−41D−2012−08 TCGA−CV−6959−01A−11D−1912−08 TCGA−CV−6956−01A−21D−2012−08 TCGA−CV−6953−01A−11D−1912−08 TCGA−CV−6948−01A−11D−1912−08 TCGA−CV−6945−01A−11D−1912−08 TCGA−CV−6943−01A−11D−1912−08 TCGA−CV−6940−01A−11D−1912−08 TCGA−CV−6936−01A−11D−1912−08 TCGA−CV−6935−01A−11D−1912−08 TCGA−CV−6933−01A−11D−1912−08 TCGA−CV−6003−01A−11D−1683−08 TCGA−CV−5979−01A−11D−1683−08 TCGA−CV−5978−01A−11D−1683−08 TCGA−CV−5977−01A−11D−1683−08 TCGA−CV−5976−01A−11D−1683−08 TCGA−CV−5973−01A−11D−1683−08 TCGA−CV−5970−01A−11D−1683−08 TCGA−CV−5966−01A−11D−1683−08 TCGA−CV−5444−01A−02D−1512−08 TCGA−CV−5440−01A−01D−1512−08 TCGA−CV−5436−01A−01D−1512−08 TCGA−CV−5435−01A−01D−1683−08 TCGA−CV−5434−01A−01D−1683−08 TCGA−CV−5432−01A−02D−1683−08 TCGA−CV−5431−01A−01D−1512−08 TCGA−CR−7398−01A−11D−2012−08 TCGA−CR−7397−01A−11D−2012−08 TCGA−CR−7393−01A−11D−2012−08 TCGA−CR−7390−01A−11D−2012−08 TCGA−CR−7389−01A−11D−2012−08 TCGA−CR−7383−01A−11D−2129−08 TCGA−CR−7379−01A−11D−2012−08 TCGA−CR−7376−01A−11D−2129−08 TCGA−CR−7374−01A−11D−2012−08 TCGA−CR−7372−01A−11D−2012−08 TCGA−CR−7370−01A−11D−2129−08 TCGA−CR−6493−01A−11D−1870−08 TCGA−CR−6477−01A−11D−1870−08 TCGA−CQ−7067−01A−11D−2229−08 TCGA−CQ−7065−01A−11D−2078−08 TCGA−CQ−6229−01A−11D−1912−08 TCGA−CQ−6228−01A−11D−1912−08 TCGA−CQ−6225−01A−11D−1912−08 TCGA−CQ−6223−01A−11D−1912−08 TCGA−CQ−6222−01A−11D−1912−08 TCGA−CQ−6221−01A−11D−2078−08 TCGA−CQ−5331−01A−02D−1870−08 TCGA−CQ−5330−01A−01D−1683−08 TCGA−CQ−5329−01A−01D−1683−08 TCGA−CQ−5326−01A−01D−1870−08 TCGA−CN−6998−01A−23D−2012−08 TCGA−CN−6996−01A−11D−1912−08 TCGA−CN−6995−01A−31D−2012−08 TCGA−CN−6994−01A−11D−1912−08 TCGA−CN−6989−01A−11D−1912−08 TCGA−CN−6988−01A−11D−1912−08 TCGA−CN−6022−01A−21D−1683−08 TCGA−CN−6021−01A−11D−1683−08 TCGA−CN−6020−01A−11D−1683−08 TCGA−CN−6019−01A−11D−1683−08 TCGA−CN−6018−01A−11D−1683−08 TCGA−CN−6017−01A−11D−1683−08 TCGA−CN−6016−01A−11D−1683−08 TCGA−CN−6013−01A−11D−1683−08 TCGA−CN−6012−01A−11D−1683−08 TCGA−CN−6011−01A−11D−1683−08 TCGA−CN−5370−01A−01D−2012−08 TCGA−CN−5367−01A−01D−1434−08 TCGA−CN−5366−01A−01D−1434−08 TCGA−CN−5365−01A−01D−1434−08 TCGA−CN−5363−01A−01D−1434−08 TCGA−CN−5360−01A−01D−1434−08 TCGA−CN−5359−01A−01D−1434−08 TCGA−CN−4742−01A−02D−1512−08 TCGA−CN−4738−01A−02D−1512−08 TCGA−CN−4737−01A−01D−1434−08 TCGA−CN−4736−01A−01D−1434−08 TCGA−CN−4735−01A−01D−1434−08 TCGA−CN−4733−01A−02D−1870−08 TCGA−CN−4731−01A−01D−1434−08 TCGA−CN−4729−01A−01D−1434−08 TCGA−CN−4728−01A−01D−1434−08 TCGA−CN−4727−01A−01D−1434−08 TCGA−CN−4726−01A−01D−1434−08 TCGA−CN−4725−01A−01D−1434−08 TCGA−BB−7871−01A−11D−2229−08 TCGA−BB−7870−01A−11D−2229−08 TCGA−BB−7862−01A−21D−2229−08 TCGA−BB−4227−01A−01D−1870−08 TCGA−BB−4217−01A−11D−2078−08 TCGA−BA−7269−01A−11D−2012−08 TCGA−BA−6873−01A−11D−1870−08 TCGA−BA−6872−01A−11D−1870−08 TCGA−BA−6870−01A−11D−1870−08 TCGA−BA−6869−01A−11D−1870−08 TCGA−BA−6868−01B−12D−1912−08 TCGA−BA−5557−01A−01D−1512−08 TCGA−BA−5555−01A−01D−1512−08 TCGA−BA−5152−01A−02D−1870−08 TCGA−BA−5151−01A−01D−1434−08 TCGA−BA−4078−01A−01D−1434−08 HN_63114−Tumor HN_63058−Tumor HN_63048−Tumor HN_63039−Tumor HN_63007−Tumor HN_62995−Tumor HN_62984−Tumor HN_62926−Tumor HN_62921−Tumor HN_62897−Tumor HN_62857_2−Tumor HN_62832−Tumor HN_62814−Tumor HN_62741−Tumor HN_62739−Tumor HN_62671−Tumor HN_62601−Tumor HN_62539−Tumor HN_62532−Tumor HN_62515−Tumor HN_62505−Tumor HN_62493−Tumor HN_62469−Tumor HN_62376−Tumor HN_62338−Tumor HN_62332−Tumor HN_62298−Tumor HN_01000−Tumor HN_00443−Tumor HN_00378−Tumor HN_00313−Tumor HN_00190−Tumor HN_0−046−Tumor

TCGA−BB−7872−01A−11D−2229−08 TCGA−CV−7406−01A−11D−2078−08 HN_62481−Tumor TCGA−CR−6488−01A−12D−2078−08 TCGA−CR−5243−01A−01D−1512−08 TCGA−IQ−7632−01A−11D−2078−08 TCGA−CV−7429−01A−11D−2129−08 TCGA−CR−7401−01A−11D−2012−08 HN_62825−Tumor TCGA−BB−7864−01A−11D−2229−08 TCGA−CR−7404−01A−11D−2129−08 TCGA−CN−6010−01A−11D−1683−08 TCGA−CR−6471−01A−11D−1870−08 HN_62756−Tumor HN_62686−Tumor TCGA−DQ−5625−01A−01D−1870−08 HN_62672−Tumor HN_63021−Tumor HN_62415−Tumor TCGA−CV−7411−01A−11D−2078−08 TCGA−CV−6938−01A−11D−1912−08 TCGA−CV−7427−01A−11D−2078−08 TCGA−CV−7243−01A−11D−2012−08 HN_62755−Tumor HN_62318−Tumor HN_62421−Tumor TCGA−CQ−5323−01A−01D−1683−08 TCGA−CR−6470−01A−11D−1870−08 TCGA−CV−6954−01A−11D−1912−08 TCGA−HD−7754−01A−11D−2078−08 TCGA−CR−7395−01A−11D−2012−08 TCGA−CR−7367−01A−11D−2012−08 TCGA−CR−7369−01A−11D−2129−08 TCGA−CN−5355−01A−01D−1434−08 TCGA−BB−4223−01A−01D−1434−08 TCGA−CV−7250−01A−11D−2012−08 TCGA−CN−4734−01A−01D−1434−08 TCGA−CV−7440−01A−11D−2129−08 TCGA−CR−5248−01A−01D−2012−08 TCGA−BA−5559−01A−01D−1512−08 TCGA−CQ−5324−01A−01D−1683−08 TCGA−CN−5369−01A−01D−1434−08 TCGA−BA−5556−01A−01D−1512−08 TCGA−BA−4077−01B−01D−1434−08 TCGA−CV−6961−01A−21D−1912−08 HN_62699−Tumor TCGA−CR−6481−01A−11D−1870−08 TCGA−CR−5247−01A−01D−2012−08 HN_62861−Tumor TCGA−HD−7753−01A−11D−2078−08 TCGA−DQ−7591−01A−11D−2078−08 TCGA−CV−6941−01A−11D−1912−08 TCGA−CV−5971−01A−11D−1683−08 TCGA−BA−6871−01A−11D−1870−08 HN_00076−Tumor TCGA−CR−7386−01A−11D−2012−08 TCGA−DQ−7595−01A−11D−2229−08 TCGA−CV−7422−01A−21D−2078−08 TCGA−CV−7414−01A−11D−2078−08 TCGA−CV−7101−01A−11D−2012−08 TCGA−CR−6484−01A−11D−1870−08 TCGA−CQ−5332−01A−01D−1683−08 TCGA−CN−6013−01A−11D−1683−08 TCGA−CN−5356−01A−01D−1434−08 TCGA−F7−7848−01A−11D−2129−08 TCGA−CX−7086−01A−11D−2078−08 TCGA−CV−7248−01A−11D−2012−08 TCGA−CV−7245−01A−11D−2012−08 TCGA−CV−7242−01A−11D−2012−08 TCGA−CV−7099−01A−41D−2012−08 TCGA−CV−7091−01A−11D−2012−08 TCGA−CV−6950−01A−11D−1912−08 TCGA−CV−6937−01A−11D−2012−08 TCGA−CV−6436−01A−11D−1683−08 TCGA−CV−5966−01A−11D−1683−08 TCGA−CV−5439−01A−01D−1683−08 TCGA−CV−5432−01A−02D−1683−08 TCGA−CV−5430−01A−02D−1683−08 TCGA−CR−7390−01A−11D−2012−08 TCGA−CR−7380−01A−11D−2012−08 TCGA−CR−7374−01A−11D−2012−08 TCGA−CR−7368−01A−11D−2129−08 TCGA−CR−7365−01A−11D−2012−08 TCGA−CR−7364−01A−11D−2012−08 TCGA−CQ−6225−01A−11D−1912−08 TCGA−CQ−6223−01A−11D−1912−08 TCGA−CQ−6219−01A−11D−1912−08 TCGA−CQ−6218−01A−11D−1912−08 TCGA−CQ−5334−01A−01D−1683−08 TCGA−CN−6992−01A−11D−1912−08 TCGA−CN−6989−01A−11D−1912−08 TCGA−CN−6023−01A−11D−1683−08 TCGA−CN−4739−01A−02D−1512−08 TCGA−CN−4727−01A−01D−1434−08 TCGA−BB−7871−01A−11D−2229−08 TCGA−BA−5558−01A−01D−1512−08 TCGA−BA−4075−01A−01D−1434−08 HN_63081−Tumor HN_63080−Tumor HN_63058−Tumor HN_62739−Tumor HN_62646−Tumor HN_62506−Tumor TCGA−HD−7831−01A−11D−2129−08 TCGA−HD−7229−01A−11D−2012−08 TCGA−DQ−5630−01A−01D−1870−08 TCGA−DQ−5629−01A−01D−1870−08 TCGA−DQ−5624−01A−01D−1870−08 TCGA−D6−6826−01A−11D−1912−08 TCGA−D6−6823−01A−11D−1912−08 TCGA−CX−7219−01A−11D−2012−08 TCGA−CV−7437−01A−21D−2129−08 TCGA−CV−7435−01A−11D−2129−08 TCGA−CV−7433−01A−11D−2129−08 TCGA−CV−7418−01A−11D−2078−08 TCGA−CV−7415−01A−11D−2078−08 TCGA−CV−7263−01A−11D−2012−08 TCGA−CV−7255−01A−11D−2012−08 TCGA−CV−7254−01A−11D−2012−08 TCGA−CV−7252−01A−11D−2012−08 TCGA−CV−7236−01A−11D−2012−08 TCGA−CV−7103−01A−21D−2012−08 TCGA−CV−7097−01A−11D−2012−08 TCGA−CV−7089−01A−11D−2012−08 TCGA−CV−6956−01A−21D−2012−08 TCGA−CV−6951−01A−11D−1912−08 TCGA−CV−6948−01A−11D−1912−08 TCGA−CV−6945−01A−11D−1912−08 TCGA−CV−6942−01A−21D−2012−08 TCGA−CV−6936−01A−11D−1912−08 TCGA−CV−6934−01A−11D−1912−08 TCGA−CV−5977−01A−11D−1683−08 TCGA−CV−5444−01A−02D−1512−08 TCGA−CV−5440−01A−01D−1512−08 TCGA−CV−5435−01A−01D−1683−08 TCGA−CR−7394−01A−11D−2012−08 TCGA−CR−7383−01A−11D−2129−08 TCGA−CR−7377−01A−11D−2012−08 TCGA−CR−7371−01A−11D−2012−08 TCGA−CR−6478−01A−11D−1870−08 TCGA−CR−6477−01A−11D−1870−08 TCGA−CR−6474−01A−11D−1870−08 TCGA−CQ−7065−01A−11D−2078−08 TCGA−CQ−6229−01A−11D−1912−08 TCGA−CQ−6224−01A−11D−1912−08 TCGA−CN−6997−01A−11D−2012−08 TCGA−CN−6995−01A−31D−2012−08 TCGA−CN−6024−01A−11D−1683−08 TCGA−CN−6012−01A−11D−1683−08 TCGA−CN−6011−01A−11D−1683−08 TCGA−CN−5373−01A−01D−1434−08 TCGA−CN−5370−01A−01D−2012−08 TCGA−CN−5364−01A−01D−1434−08 TCGA−CN−5360−01A−01D−1434−08 TCGA−CN−4740−01A−01D−1434−08 TCGA−CN−4738−01A−02D−1512−08 TCGA−CN−4731−01A−01D−1434−08 TCGA−CN−4729−01A−01D−1434−08 TCGA−CN−4728−01A−01D−1434−08 TCGA−BB−7870−01A−11D−2229−08 TCGA−BB−4227−01A−01D−1870−08 TCGA−BB−4224−01A−01D−1434−08 TCGA−BA−6872−01A−11D−1870−08 TCGA−BA−4076−01A−01D−1434−08 HN_63007−Tumor HN_62652−Tumor HN_62532−Tumor HN_62469−Tumor HN_62432−Tumor HN_62338−Tumor HN_00190−Tumor TCGA−IQ−7630−01A−11D−2078−08 TCGA−HD−7917−01A−11D−2229−08 TCGA−DQ−7592−01A−11D−2078−08 TCGA−DQ−7588−01A−11D−2078−08 TCGA−DQ−5631−01A−01D−1870−08 TCGA−D6−6825−01A−21D−1912−08 TCGA−D6−6824−01A−11D−1912−08 TCGA−D6−6517−01A−11D−1870−08 TCGA−D6−6515−01A−21D−1870−08 TCGA−CX−7082−01A−11D−2012−08 TCGA−CV−7438−01A−21D−2129−08 TCGA−CV−7434−01A−11D−2129−08 TCGA−CV−7432−01A−11D−2129−08 TCGA−CV−7430−01A−11D−2129−08 TCGA−CV−7424−01A−11D−2078−08 TCGA−CV−7421−01A−11D−2078−08 TCGA−CV−7416−01A−11D−2078−08 TCGA−CV−7413−01A−11D−2078−08 TCGA−CV−7409−01A−31D−2229−08 TCGA−CV−7253−01A−11D−2012−08 TCGA−CV−7247−01A−11D−2012−08 TCGA−CV−7238−01A−11D−2012−08 TCGA−CV−7235−01A−11D−2012−08 TCGA−CV−7180−01A−11D−2012−08 TCGA−CV−7177−01A−11D−2012−08 TCGA−CV−7104−01A−11D−2012−08 TCGA−CV−7102−01A−11D−2012−08 TCGA−CV−7095−01A−21D−2012−08 TCGA−CV−7090−01A−11D−2012−08 TCGA−CV−6962−01A−11D−1912−08 TCGA−CV−6960−01A−41D−2012−08 TCGA−CV−6959−01A−11D−1912−08 TCGA−CV−6953−01A−11D−1912−08 TCGA−CV−6952−01A−11D−1912−08 TCGA−CV−6943−01A−11D−1912−08 TCGA−CV−6940−01A−11D−1912−08 TCGA−CV−6935−01A−11D−1912−08 TCGA−CV−6933−01A−11D−1912−08 TCGA−CV−6003−01A−11D−1683−08 TCGA−CV−5979−01A−11D−1683−08 TCGA−CV−5978−01A−11D−1683−08 TCGA−CV−5976−01A−11D−1683−08 TCGA−CV−5973−01A−11D−1683−08 TCGA−CV−5970−01A−11D−1683−08 TCGA−CV−5436−01A−01D−1512−08 TCGA−CV−5434−01A−01D−1683−08 TCGA−CV−5431−01A−01D−1512−08 TCGA−CR−7399−01A−11D−2012−08 TCGA−CR−7398−01A−11D−2012−08 TCGA−CR−7397−01A−11D−2012−08 TCGA−CR−7393−01A−11D−2012−08 TCGA−CR−7389−01A−11D−2012−08 TCGA−CR−7379−01A−11D−2012−08 TCGA−CR−7376−01A−11D−2129−08 TCGA−CR−7372−01A−11D−2012−08 TCGA−CR−7370−01A−11D−2129−08 TCGA−CR−6493−01A−11D−1870−08 TCGA−CR−6491−01A−11D−1870−08 TCGA−CQ−7067−01A−11D−2229−08 TCGA−CQ−6228−01A−11D−1912−08 TCGA−CQ−6222−01A−11D−1912−08 TCGA−CQ−6221−01A−11D−2078−08 TCGA−CQ−6220−01A−11D−1912−08 TCGA−CQ−5331−01A−02D−1870−08 TCGA−CQ−5330−01A−01D−1683−08 TCGA−CQ−5329−01A−01D−1683−08 TCGA−CQ−5326−01A−01D−1870−08 TCGA−CN−6998−01A−23D−2012−08 TCGA−CN−6996−01A−11D−1912−08 TCGA−CN−6994−01A−11D−1912−08 TCGA−CN−6988−01A−11D−1912−08 TCGA−CN−6022−01A−21D−1683−08 TCGA−CN−6021−01A−11D−1683−08 TCGA−CN−6020−01A−11D−1683−08 TCGA−CN−6019−01A−11D−1683−08 TCGA−CN−6018−01A−11D−1683−08 TCGA−CN−6017−01A−11D−1683−08 TCGA−CN−6016−01A−11D−1683−08 TCGA−CN−5367−01A−01D−1434−08 TCGA−CN−5366−01A−01D−1434−08 TCGA−CN−5365−01A−01D−1434−08 TCGA−CN−5363−01A−01D−1434−08 TCGA−CN−5359−01A−01D−1434−08 TCGA−CN−4742−01A−02D−1512−08 TCGA−CN−4737−01A−01D−1434−08 TCGA−CN−4736−01A−01D−1434−08 TCGA−CN−4735−01A−01D−1434−08 TCGA−CN−4733−01A−02D−1870−08 TCGA−CN−4726−01A−01D−1434−08 TCGA−CN−4725−01A−01D−1434−08 TCGA−BB−7862−01A−21D−2229−08 TCGA−BB−4217−01A−11D−2078−08 TCGA−BA−7269−01A−11D−2012−08 TCGA−BA−6873−01A−11D−1870−08 TCGA−BA−6870−01A−11D−1870−08 TCGA−BA−6869−01A−11D−1870−08 TCGA−BA−6868−01B−12D−1912−08 TCGA−BA−5557−01A−01D−1512−08 TCGA−BA−5555−01A−01D−1512−08 TCGA−BA−5152−01A−02D−1870−08 TCGA−BA−5151−01A−01D−1434−08 TCGA−BA−4078−01A−01D−1434−08 TCGA−BA−4074−01A−01D−1434−08 HN_63114−Tumor HN_63048−Tumor HN_63039−Tumor HN_62995−Tumor HN_62984−Tumor HN_62926−Tumor HN_62921−Tumor HN_62897−Tumor HN_62857_2−Tumor HN_62832−Tumor HN_62814−Tumor HN_62741−Tumor HN_62671−Tumor HN_62601−Tumor HN_62539−Tumor HN_62515−Tumor HN_62505−Tumor HN_62493−Tumor HN_62376−Tumor HN_62332−Tumor HN_62298−Tumor HN_01000−Tumor HN_00443−Tumor HN_00378−Tumor HN_00313−Tumor HN_0−046−Tumor

TCGA−CQ−5324−01A−01D−1683−08 TCGA−CN−4734−01A−01D−1434−08 TCGA−CV−5970−01A−11D−1683−08 TCGA−BA−5152−01A−02D−1870−08 TCGA−BA−6870−01A−11D−1870−08 TCGA−CX−7082−01A−11D−2012−08 HN_00761−Tumor HN_62298−Tumor TCGA−CQ−5332−01A−01D−1683−08 TCGA−CN−4739−01A−02D−1512−08 TCGA−CV−7429−01A−11D−2129−08 TCGA−CR−7401−01A−11D−2012−08 HN_62825−Tumor TCGA−CR−6478−01A−11D−1870−08 TCGA−CN−4740−01A−01D−1434−08 TCGA−DQ−7592−01A−11D−2078−08 TCGA−CV−7433−01A−11D−2129−08 TCGA−CR−7380−01A−11D−2012−08 TCGA−BA−4074−01A−01D−1434−08 TCGA−CR−7392−01A−11D−2012−08 TCGA−CN−6020−01A−11D−1683−08 TCGA−BA−4077−01B−01D−1434−08 HN_00122−Tumor TCGA−CR−6488−01A−12D−2078−08 TCGA−CQ−6219−01A−11D−1912−08 TCGA−CR−7377−01A−11D−2012−08 TCGA−CR−6472−01A−11D−1870−08 HN_63021−Tumor TCGA−CV−7263−01A−11D−2012−08 TCGA−CR−6484−01A−11D−1870−08 HN_62318−Tumor TCGA−CV−6962−01A−11D−1912−08 TCGA−CV−6951−01A−11D−1912−08 TCGA−CV−7255−01A−11D−2012−08 TCGA−CR−7385−01A−11D−2012−08 HN_62739−Tumor TCGA−CV−7097−01A−11D−2012−08 TCGA−IQ−7632−01A−11D−2078−08 TCGA−CV−6956−01A−21D−2012−08 TCGA−HD−7832−01A−11D−2129−08 HN_63080−Tumor TCGA−CR−7365−01A−11D−2012−08 TCGA−CN−4735−01A−01D−1434−08 HN_63081−Tumor TCGA−CV−6938−01A−11D−1912−08 TCGA−CR−5247−01A−01D−2012−08 TCGA−CV−7414−01A−11D−2078−08 TCGA−CR−5248−01A−01D−2012−08 TCGA−CR−5243−01A−01D−1512−08 TCGA−CV−6436−01A−11D−1683−08 TCGA−BB−4223−01A−01D−1434−08 TCGA−CV−5430−01A−02D−1683−08 TCGA−CN−6992−01A−11D−1912−08 TCGA−CV−7089−01A−11D−2012−08 TCGA−CR−7399−01A−11D−2012−08 TCGA−CR−6480−01A−11D−1870−08 TCGA−CV−7243−01A−11D−2012−08 TCGA−CV−7236−01A−11D−2012−08 TCGA−BB−4224−01A−01D−1434−08 TCGA−BA−5558−01A−01D−1512−08 TCGA−CV−7099−01A−41D−2012−08 TCGA−CR−6481−01A−11D−1870−08 TCGA−CX−7219−01A−11D−2012−08 TCGA−CV−5434−01A−01D−1683−08 TCGA−CN−5367−01A−01D−1434−08 TCGA−CV−7242−01A−11D−2012−08 TCGA−CV−7101−01A−11D−2012−08 TCGA−CV−6954−01A−11D−1912−08 TCGA−CV−6937−01A−11D−2012−08 TCGA−CR−6470−01A−11D−1870−08 TCGA−CN−6023−01A−11D−1683−08 TCGA−DQ−5624−01A−01D−1870−08 TCGA−CV−7422−01A−21D−2078−08 TCGA−CV−7103−01A−21D−2012−08 TCGA−CN−6995−01A−31D−2012−08 TCGA−CN−6989−01A−11D−1912−08 HN_63058−Tumor HN_62861−Tumor HN_62421−Tumor TCGA−CN−5356−01A−01D−1434−08 TCGA−CQ−6218−01A−11D−1912−08 TCGA−BA−6872−01A−11D−1870−08 TCGA−CV−7435−01A−11D−2129−08 TCGA−CV−7427−01A−11D−2078−08 TCGA−CR−7404−01A−11D−2129−08 TCGA−CR−7367−01A−11D−2012−08 TCGA−CQ−5334−01A−01D−1683−08 TCGA−BB−4227−01A−01D−1870−08 TCGA−IQ−7630−01A−11D−2078−08 TCGA−DQ−7588−01A−11D−2078−08 TCGA−CX−7086−01A−11D−2078−08 TCGA−CV−7407−01A−11D−2078−08 TCGA−CV−6948−01A−11D−1912−08 TCGA−CV−6933−01A−11D−1912−08 TCGA−CN−6024−01A−11D−1683−08 TCGA−CN−6010−01A−11D−1683−08 TCGA−CN−5373−01A−01D−1434−08 TCGA−BA−6868−01B−12D−1912−08 HN_62854−Tumor HN_62426−Tumor TCGA−CN−5369−01A−01D−1434−08 TCGA−CN−6011−01A−11D−1683−08 TCGA−BA−4075−01A−01D−1434−08 TCGA−F7−7848−01A−11D−2129−08 TCGA−CV−7409−01A−31D−2229−08 TCGA−CV−7250−01A−11D−2012−08 TCGA−CV−7248−01A−11D−2012−08 TCGA−CV−7245−01A−11D−2012−08 TCGA−CV−5442−01A−01D−1512−08 TCGA−CR−7394−01A−11D−2012−08 TCGA−CN−6013−01A−11D−1683−08 TCGA−CN−4727−01A−01D−1434−08 HN_62755−Tumor HN_62646−Tumor HN_62415−Tumor TCGA−DQ−7595−01A−11D−2229−08 TCGA−DQ−5629−01A−01D−1870−08 TCGA−D6−6823−01A−11D−1912−08 TCGA−CV−7411−01A−11D−2078−08 TCGA−CV−6955−01A−11D−2012−08 TCGA−CV−6942−01A−21D−2012−08 TCGA−CV−6936−01A−11D−1912−08 TCGA−CV−5439−01A−01D−1683−08 TCGA−CR−7386−01A−11D−2012−08 TCGA−CR−7371−01A−11D−2012−08 TCGA−CR−7368−01A−11D−2129−08 TCGA−CR−7364−01A−11D−2012−08 TCGA−CN−6021−01A−11D−1683−08 TCGA−CN−5360−01A−01D−1434−08 TCGA−BB−7862−01A−21D−2229−08 TCGA−BA−6869−01A−11D−1870−08 HN_62756−Tumor HN_62699−Tumor HN_62624−Tumor HN_62506−Tumor HN_00076−Tumor TCGA−HD−7831−01A−11D−2129−08 TCGA−D6−6825−01A−21D−1912−08 TCGA−CV−7432−01A−11D−2129−08 TCGA−CV−7425−01A−11D−2078−08 TCGA−CV−7253−01A−11D−2012−08 TCGA−CV−7095−01A−21D−2012−08 TCGA−CV−6941−01A−11D−1912−08 TCGA−CV−5966−01A−11D−1683−08 TCGA−CV−5443−01A−01D−1512−08 TCGA−CV−5441−01A−01D−1512−08 TCGA−CR−7373−01A−11D−2012−08 TCGA−CR−7370−01A−11D−2129−08 TCGA−CR−6492−01A−12D−2078−08 TCGA−CR−6491−01A−11D−1870−08 TCGA−CR−6477−01A−11D−1870−08 TCGA−CR−6467−01A−11D−1870−08 TCGA−CR−5249−01A−01D−1512−08 TCGA−CN−6019−01A−11D−1683−08 TCGA−CN−5370−01A−01D−2012−08 TCGA−CN−5363−01A−01D−1434−08 TCGA−CN−4738−01A−02D−1512−08 TCGA−CN−4737−01A−01D−1434−08 TCGA−BB−7871−01A−11D−2229−08 TCGA−BB−7863−01A−11D−2229−08 TCGA−BA−5559−01A−01D−1512−08 TCGA−BA−4076−01A−01D−1434−08 HN_62897−Tumor HN_62672−Tumor HN_62505−Tumor HN_62237−Tumor HN_00378−Tumor HN_00361−Tumor HN_00190−Tumor

TCGA−CN−6988−01A−11D−1912−08 TCGA−CN−6994−01A−11D−1912−08 HN_62481−Tumor TCGA−CR−6488−01A−12D−2078−08 TCGA−CQ−5332−01A−01D−1683−08 TCGA−CN−5356−01A−01D−1434−08 TCGA−CR−6470−01A−11D−1870−08 TCGA−CN−6995−01A−31D−2012−08 TCGA−CN−4739−01A−02D−1512−08 TCGA−IQ−7632−01A−11D−2078−08 TCGA−CV−7429−01A−11D−2129−08 TCGA−CR−7401−01A−11D−2012−08 TCGA−CQ−6218−01A−11D−1912−08 TCGA−CV−6436−01A−11D−1683−08 TCGA−CR−6478−01A−11D−1870−08 TCGA−CQ−6228−01A−11D−1912−08 TCGA−CV−6441−01A−11D−1683−08 TCGA−BA−4076−01A−01D−1434−08 TCGA−CN−5369−01A−01D−1434−08 TCGA−CV−7425−01A−11D−2078−08 TCGA−CR−7377−01A−11D−2012−08 TCGA−CR−6472−01A−11D−1870−08 TCGA−CV−5441−01A−01D−1512−08 TCGA−CQ−5334−01A−01D−1683−08 TCGA−CR−7364−01A−11D−2012−08 TCGA−CQ−6225−01A−11D−1912−08 TCGA−CV−7409−01A−31D−2229−08 HN_62298−Tumor HN_62755−Tumor HN_62318−Tumor TCGA−CV−6951−01A−11D−1912−08 TCGA−CV−6962−01A−11D−1912−08 TCGA−IQ−7630−01A−11D−2078−08 TCGA−CV−6953−01A−11D−1912−08 TCGA−CQ−6219−01A−11D−1912−08 TCGA−CR−7374−01A−11D−2012−08 TCGA−CN−4734−01A−01D−1434−08 TCGA−D6−6515−01A−21D−1870−08 TCGA−CV−7416−01A−11D−2078−08 TCGA−CN−4726−01A−01D−1434−08 TCGA−CR−7365−01A−11D−2012−08 TCGA−BA−5152−01A−02D−1870−08 TCGA−CX−7086−01A−11D−2078−08 TCGA−CR−5248−01A−01D−2012−08 TCGA−CV−7414−01A−11D−2078−08 TCGA−CR−5243−01A−01D−1512−08 TCGA−CV−7422−01A−21D−2078−08 TCGA−CV−7183−01A−11D−2012−08 TCGA−CN−5359−01A−01D−1434−08 TCGA−CV−6954−01A−11D−1912−08 TCGA−CN−6011−01A−11D−1683−08 TCGA−CN−4730−01A−01D−1434−08 TCGA−CV−7255−01A−11D−2012−08 TCGA−CR−7385−01A−11D−2012−08 TCGA−CR−7368−01A−11D−2129−08 TCGA−CR−6484−01A−11D−1870−08 TCGA−CV−7406−01A−11D−2078−08 TCGA−CR−7386−01A−11D−2012−08 TCGA−CN−6023−01A−11D−1683−08 TCGA−DQ−5625−01A−01D−1870−08 TCGA−CV−6934−01A−11D−1912−08 TCGA−CN−6992−01A−11D−1912−08 HN_62672−Tumor TCGA−CV−7427−01A−11D−2078−08 TCGA−CV−7243−01A−11D−2012−08 TCGA−CV−7236−01A−11D−2012−08 TCGA−BB−4224−01A−01D−1434−08 HN_63021−Tumor TCGA−BB−4223−01A−01D−1434−08 TCGA−CV−6942−01A−21D−2012−08 TCGA−CR−7394−01A−11D−2012−08 TCGA−CN−4740−01A−01D−1434−08 HN_63080−Tumor TCGA−CV−7415−01A−11D−2078−08 TCGA−CN−6010−01A−11D−1683−08 TCGA−DQ−7595−01A−11D−2229−08 TCGA−CQ−6223−01A−11D−1912−08 TCGA−CN−4738−01A−02D−1512−08 TCGA−BB−7872−01A−11D−2229−08 TCGA−BB−4227−01A−01D−1870−08 TCGA−CV−7263−01A−11D−2012−08 TCGA−CR−7367−01A−11D−2012−08 TCGA−CR−6481−01A−11D−1870−08 TCGA−CQ−5326−01A−01D−1870−08 TCGA−CN−5374−01A−01D−1434−08 HN_63081−Tumor TCGA−CV−7435−01A−11D−2129−08 TCGA−CV−7411−01A−11D−2078−08 TCGA−CV−6938−01A−11D−1912−08 TCGA−CV−6937−01A−11D−2012−08 TCGA−CR−5247−01A−01D−2012−08 TCGA−CV−7242−01A−11D−2012−08 TCGA−CV−5978−01A−11D−1683−08 TCGA−CR−7371−01A−11D−2012−08 HN_62854−Tumor TCGA−CV−7235−01A−11D−2012−08 TCGA−CV−7103−01A−21D−2012−08 TCGA−CR−7391−01A−11D−2012−08 HN_0−046−Tumor TCGA−CV−7250−01A−11D−2012−08 HN_62699−Tumor TCGA−CV−7248−01A−11D−2012−08 TCGA−CV−7099−01A−41D−2012−08 TCGA−BA−6872−01A−11D−1870−08 TCGA−D6−6823−01A−11D−1912−08 TCGA−CV−7097−01A−11D−2012−08 TCGA−CR−7404−01A−11D−2129−08 HN_62739−Tumor TCGA−CR−7380−01A−11D−2012−08 HN_62646−Tumor TCGA−HD−7754−01A−11D−2078−08 TCGA−CX−7219−01A−11D−2012−08 TCGA−CV−6950−01A−11D−1912−08 TCGA−CR−7395−01A−11D−2012−08 TCGA−CN−5373−01A−01D−1434−08 TCGA−CN−5364−01A−01D−1434−08 HN_62432−Tumor TCGA−CV−6936−01A−11D−1912−08 TCGA−CV−5430−01A−02D−1683−08 HN_62814−Tumor HN_62505−Tumor TCGA−CV−7430−01A−11D−2129−08 TCGA−CV−7089−01A−11D−2012−08 TCGA−CV−6945−01A−11D−1912−08 TCGA−CV−5440−01A−01D−1512−08 TCGA−CR−6473−01A−11D−1870−08 TCGA−CQ−6221−01A−11D−2078−08 TCGA−CQ−5325−01A−01D−1683−08 TCGA−BA−6870−01A−11D−1870−08 TCGA−BA−6869−01A−11D−1870−08 HN_63007−Tumor HN_62376−Tumor HN_62421−Tumor TCGA−CV−7245−01A−11D−2012−08 TCGA−CV−7254−01A−11D−2012−08 HN_62825−Tumor HN_62652−Tumor HN_62506−Tumor TCGA−CV−5432−01A−02D−1683−08 TCGA−CN−6997−01A−11D−2012−08 TCGA−CN−6024−01A−11D−1683−08 TCGA−CN−4727−01A−01D−1434−08 TCGA−BA−5558−01A−01D−1512−08 HN_62897−Tumor HN_62415−Tumor HN_00190−Tumor TCGA−HD−7753−01A−11D−2078−08 TCGA−DQ−7589−01A−11D−2229−08 TCGA−CV−7424−01A−11D−2078−08 TCGA−CV−5970−01A−11D−1683−08 TCGA−CR−7379−01A−11D−2012−08 TCGA−CR−7370−01A−11D−2129−08 TCGA−CN−6012−01A−11D−1683−08 TCGA−CN−5365−01A−01D−1434−08 TCGA−CN−5360−01A−01D−1434−08 TCGA−BB−7871−01A−11D−2229−08 TCGA−BA−5555−01A−01D−1512−08 TCGA−BA−4078−01A−01D−1434−08 HN_62921−Tumor HN_62338−Tumor

Regulation Of Gene Expression By Hypoxia Inducible Factor FDR = 1.8e−06%, FDR nod = 2.3% Recruitment And ATM Mediated Phosphorylation Of Repair And Signaling Proteins At DNA Double Strand Breaks FDR = 1.9e−12%, FDR nod = 0.028%


EP300


CREBBP

wt wt

EPAS1

HIF3A

ARNT

EPO

HIF1A

TP53 HERC2 TP53BP1 WHSC1 ATM BRCA1 HIST1H2BF HIST1H2BH HIST1H2BK HIST1H4C HIST1H4E KDM4A NBN APBB1 CHEK2 EYA1 EYA4 HIST1H2BG HIST1H2BI HIST1H2BL HIST1H2BM HIST1H4D HIST1H4F HIST1H4H HIST4H4 KDM4B MRE11A PPP5C RAD50 BARD1 BAZ1B BRE EYA2 EYA3 FAM175A HIST1H2BB HIST1H2BD HIST1H2BE HIST1H2BJ HIST1H2BN HIST1H4B HIST1H4I HIST1H4K HIST1H4L HIST2H2BE KAT5 MAPK8 MDC1 PIAS4 RNF168 RPS27A SMARCA5 UBA52 UBC UBE2I UIMC1

known HCG mut

wt

unknown CG mut

known HCG mut

wt

SYNE1 SYNE2 ATR DIDO1 HIST1H2BK POT1 HIST1H2BD HIST1H4C HIST1H4E SYCP1 SYCP2 BRCA1 HIST1H2AB HIST1H2AE HIST1H2BF HIST1H4B HIST2H2AC HIST4H4 STAG3 SUN1 TERF1 ACD FKBP6 HIST1H2AC HIST1H2BB HIST1H2BG HIST1H2BI HIST1H2BL HIST1H2BN HIST2H2BE HSPA2 LMNB1 SMC3 STAG2 SUN2 SYCE2 SYCP3 H2AFZ HIST1H2AJ HIST1H2BE HIST1H2BH HIST1H2BJ HIST1H2BM HIST1H4D HIST1H4F HIST1H4H HIST1H4I HIST1H4K HIST1H4L RAD21 SMC1A SMC1B STAG1 SYCE1 TERF2 TINF2 UBE2I unknown CG mut

known HCG mut

wt PRDM9 BRCA2 ATM BRCA1 TEX15 HIST1H4E HIST1H3I RBBP8 BLM HIST1H2BH HIST1H2BK NBN RAD50 HIST1H2AB HIST1H3E HIST1H3G HIST1H4C HIST2H3D MSH4 RPA1 CDK4 HIST1H2AE HIST1H2BF HIST1H3A HIST1H3C HIST1H3J HIST2H2AC MLH1 MLH3 H3F3B HIST1H2BB HIST1H2BD HIST1H2BG HIST1H2BI HIST1H2BL HIST1H2BM HIST1H2BN HIST1H3D HIST1H4D HIST1H4F HIST2H2BE HIST4H4 MRE11A RAD51 DMC1 H2AFZ H3F3A HIST1H2AC HIST1H2AJ HIST1H2BE HIST1H2BJ HIST1H3B HIST1H3H HIST1H4B HIST1H4H HIST1H4I HIST1H4K HIST1H4L MND1 MSH5 RAD51C SPO11 TOP3A


HN_62921−Tumor TCGA−CN−4740−01A−01D−1434−08 TCGA−CV−5442−01A−01D−1512−08 TCGA−IQ−7632−01A−11D−2078−08 TCGA−CN−6024−01A−11D−1683−08 TCGA−CN−6989−01A−11D−1912−08 TCGA−CQ−6222−01A−11D−1912−08 TCGA−CR−7390−01A−11D−2012−08 TCGA−CN−5358−01A−01D−1512−08 TCGA−CV−6954−01A−11D−1912−08 TCGA−CV−7433−01A−11D−2129−08 TCGA−CV−6441−01A−11D−1683−08 TCGA−CV−7407−01A−11D−2078−08 TCGA−CR−6474−01A−11D−1870−08 TCGA−CV−7177−01A−11D−2012−08 TCGA−CN−6023−01A−11D−1683−08 TCGA−CR−5250−01A−01D−1512−08 TCGA−BA−5151−01A−01D−1434−08 TCGA−CR−6480−01A−11D−1870−08 TCGA−CN−5369−01A−01D−1434−08 TCGA−CV−6948−01A−11D−1912−08 HN_63058−Tumor TCGA−CQ−5334−01A−01D−1683−08 TCGA−BA−4078−01A−01D−1434−08 TCGA−IQ−7630−01A−11D−2078−08 TCGA−CV−7250−01A−11D−2012−08 TCGA−CR−5243−01A−01D−1512−08 TCGA−BA−6868−01B−12D−1912−08 TCGA−DQ−5631−01A−01D−1870−08 TCGA−CV−7102−01A−11D−2012−08 TCGA−CN−5363−01A−01D−1434−08 TCGA−CV−7440−01A−11D−2129−08 TCGA−CV−7091−01A−11D−2012−08 TCGA−CR−6477−01A−11D−1870−08 TCGA−CN−4729−01A−01D−1434−08 TCGA−CR−7374−01A−11D−2012−08 TCGA−DQ−7594−01A−11D−2229−08 TCGA−CX−7085−01A−21D−2012−08 TCGA−CV−6939−01A−11D−1912−08 TCGA−CR−7398−01A−11D−2012−08 HN_63081−Tumor TCGA−BA−5152−01A−02D−1870−08 TCGA−CV−5970−01A−11D−1683−08 TCGA−DQ−7589−01A−11D−2229−08 TCGA−CR−6472−01A−11D−1870−08 TCGA−CN−4741−01A−01D−1434−08 HN_62755−Tumor TCGA−CV−7438−01A−21D−2129−08 TCGA−CV−7418−01A−11D−2078−08 TCGA−CV−7406−01A−11D−2078−08 TCGA−CV−7255−01A−11D−2012−08 TCGA−CV−7252−01A−11D−2012−08 TCGA−CR−7404−01A−11D−2129−08 TCGA−CR−6484−01A−11D−1870−08 TCGA−CN−4727−01A−01D−1434−08 TCGA−BB−4217−01A−11D−2078−08 HN_62741−Tumor TCGA−CV−7089−01A−11D−2012−08 TCGA−CV−7430−01A−11D−2129−08 TCGA−CV−6936−01A−11D−1912−08 TCGA−CV−5430−01A−02D−1683−08 TCGA−CR−6473−01A−11D−1870−08 TCGA−CQ−6221−01A−11D−2078−08 TCGA−CQ−5325−01A−01D−1683−08 TCGA−BA−6870−01A−11D−1870−08 HN_63007−Tumor HN_62505−Tumor HN_62376−Tumor TCGA−DQ−7592−01A−11D−2078−08 TCGA−CR−6481−01A−11D−1870−08 TCGA−CN−6988−01A−11D−1912−08 TCGA−BA−6869−01A−11D−1870−08 HN_62814−Tumor TCGA−IQ−7631−01A−11D−2078−08 TCGA−CV−7434−01A−11D−2129−08 TCGA−CV−7429−01A−11D−2129−08 TCGA−CR−6478−01A−11D−1870−08 TCGA−BA−4074−01A−01D−1434−08 HN_62897−Tumor HN_62740−Tumor HN_62739−Tumor HN_62506−Tumor TCGA−CN−6011−01A−11D−1683−08 TCGA−BA−4076−01A−01D−1434−08 TCGA−H7−7774−01A−21D−2078−08 TCGA−DQ−7595−01A−11D−2229−08 TCGA−CX−7219−01A−11D−2012−08 TCGA−CV−7095−01A−21D−2012−08 TCGA−CR−6487−01A−11D−1870−08 TCGA−CQ−5327−01A−01D−1683−08 HN_62652−Tumor TCGA−CV−7427−01A−11D−2078−08 TCGA−CV−7100−01A−11D−2012−08 TCGA−CV−6938−01A−11D−1912−08 TCGA−CV−5434−01A−01D−1683−08 TCGA−CR−7395−01A−11D−2012−08 TCGA−CR−6471−01A−11D−1870−08 TCGA−CR−6470−01A−11D−1870−08 TCGA−BB−7863−01A−11D−2229−08 TCGA−BA−5559−01A−01D−1512−08 HN_62672−Tumor TCGA−CN−5370−01A−01D−2012−08 TCGA−DQ−5629−01A−01D−1870−08 TCGA−D6−6825−01A−21D−1912−08 TCGA−CV−7424−01A−11D−2078−08 TCGA−CV−7409−01A−31D−2229−08 TCGA−CV−7254−01A−11D−2012−08 TCGA−CV−7245−01A−11D−2012−08 TCGA−CV−7243−01A−11D−2012−08 TCGA−CV−7178−01A−21D−2012−08 TCGA−CV−7101−01A−11D−2012−08 TCGA−CV−6962−01A−11D−1912−08 TCGA−CV−6953−01A−11D−1912−08 TCGA−CV−6951−01A−11D−1912−08 TCGA−CV−6945−01A−11D−1912−08 TCGA−CV−6943−01A−11D−1912−08 TCGA−CV−6942−01A−21D−2012−08 TCGA−CV−5440−01A−01D−1512−08 TCGA−CV−5432−01A−02D−1683−08 TCGA−CR−7394−01A−11D−2012−08 TCGA−CR−7370−01A−11D−2129−08 TCGA−CQ−5331−01A−02D−1870−08 TCGA−CQ−5326−01A−01D−1870−08 TCGA−CN−5360−01A−01D−1434−08 TCGA−CN−4736−01A−01D−1434−08 TCGA−BA−4075−01A−01D−1434−08 HN_62532−Tumor TCGA−D6−6515−01A−21D−1870−08 TCGA−CV−7414−01A−11D−2078−08 TCGA−CV−7413−01A−11D−2078−08 TCGA−CV−7248−01A−11D−2012−08 TCGA−CV−7180−01A−11D−2012−08 TCGA−CV−6959−01A−11D−1912−08 TCGA−CV−6941−01A−11D−1912−08 TCGA−CV−6436−01A−11D−1683−08 TCGA−CV−6003−01A−11D−1683−08 TCGA−CV−5977−01A−11D−1683−08 TCGA−CV−5976−01A−11D−1683−08 TCGA−CV−5973−01A−11D−1683−08 TCGA−CV−5444−01A−02D−1512−08 TCGA−CR−7386−01A−11D−2012−08 TCGA−CR−7380−01A−11D−2012−08 TCGA−CR−6492−01A−12D−2078−08 TCGA−CR−5247−01A−01D−2012−08 TCGA−CQ−6229−01A−11D−1912−08 TCGA−CQ−6224−01A−11D−1912−08 TCGA−CQ−6220−01A−11D−1912−08 TCGA−CN−6998−01A−23D−2012−08 TCGA−CN−6997−01A−11D−2012−08 TCGA−CN−6996−01A−11D−1912−08 TCGA−CN−6021−01A−11D−1683−08 TCGA−CN−6013−01A−11D−1683−08 TCGA−CN−6012−01A−11D−1683−08 TCGA−CN−5373−01A−01D−1434−08 TCGA−CN−5359−01A−01D−1434−08 TCGA−CN−4738−01A−02D−1512−08 TCGA−BB−7862−01A−21D−2229−08 TCGA−BA−7269−01A−11D−2012−08 TCGA−BA−6873−01A−11D−1870−08 TCGA−BA−6872−01A−11D−1870−08 TCGA−BA−5558−01A−01D−1512−08 TCGA−BA−5557−01A−01D−1512−08 HN_62984−Tumor HN_62860−Tumor HN_62515−Tumor HN_00443−Tumor HN_00313−Tumor HN_0−064−Tumor

Meiotic Synapsis FDR = 1.7e−07%, FDR nod = 9e−09% Meiotic Recombination FDR = 1.7e−11%, FDR nod = 1.4e−10%

unknown CG mut

known HCG mut

wt


CDKN2A EP300 CREBBP BRCA2 LAMA4 NFATC3 RB1 CHEK2 AURKB CDC25B CDK4 CENPF ETV5 FOXM1 MAP2K1 MMP2 CCNA2 CCNB1 CCND1 CCNE1 CENPB ESR1 FOS MYC NEK2 ONECUT1 PLK1 SKP2 SP1 CENPA CKS1B XRCC1

unknown CG mut


FOXM1 Transcription Factor Network FDR = 2e−12%, FDR nod = 0.006%

TCGA−CR−6477−01A−11D−1870−08 TCGA−CN−4731−01A−01D−1434−08 TCGA−CV−7438−01A−21D−2129−08 TCGA−CV−6955−01A−11D−2012−08 TCGA−CV−7250−01A−11D−2012−08 TCGA−CV−7097−01A−11D−2012−08 TCGA−CN−4729−01A−01D−1434−08 TCGA−BA−5558−01A−01D−1512−08 TCGA−IQ−7630−01A−11D−2078−08 TCGA−CV−7440−01A−11D−2129−08 TCGA−CV−7102−01A−11D−2012−08 TCGA−CV−6952−01A−11D−1912−08 TCGA−CR−6472−01A−11D−1870−08 TCGA−CV−7248−01A−11D−2012−08 TCGA−CV−7245−01A−11D−2012−08 TCGA−CN−4741−01A−01D−1434−08 TCGA−BB−7862−01A−21D−2229−08 TCGA−BA−5555−01A−01D−1512−08 HN_63115−Tumor TCGA−IQ−7631−01A−11D−2078−08 TCGA−DQ−7592−01A−11D−2078−08 TCGA−CV−7434−01A−11D−2129−08 TCGA−CV−7429−01A−11D−2129−08 TCGA−CV−6962−01A−11D−1912−08 TCGA−CV−6951−01A−11D−1912−08 TCGA−CV−5432−01A−02D−1683−08 TCGA−CR−6481−01A−11D−1870−08 TCGA−CR−6478−01A−11D−1870−08 TCGA−CN−6988−01A−11D−1912−08 TCGA−CN−4736−01A−01D−1434−08 TCGA−BA−6869−01A−11D−1870−08 TCGA−BA−4074−01A−01D−1434−08 HN_62897−Tumor HN_62814−Tumor HN_62740−Tumor HN_62739−Tumor HN_62506−Tumor TCGA−H7−7774−01A−21D−2078−08 TCGA−DQ−7595−01A−11D−2229−08 TCGA−CX−7219−01A−11D−2012−08 TCGA−CV−7427−01A−11D−2078−08 TCGA−CV−7178−01A−21D−2012−08 TCGA−CV−7100−01A−11D−2012−08 TCGA−CV−7095−01A−21D−2012−08 TCGA−CV−6943−01A−11D−1912−08 TCGA−CV−6938−01A−11D−1912−08 TCGA−CV−5434−01A−01D−1683−08 TCGA−CR−7395−01A−11D−2012−08 TCGA−CR−7394−01A−11D−2012−08 TCGA−CR−6487−01A−11D−1870−08 TCGA−CR−6471−01A−11D−1870−08 TCGA−CR−6470−01A−11D−1870−08 TCGA−CQ−5331−01A−02D−1870−08 TCGA−CQ−5327−01A−01D−1683−08 TCGA−CQ−5326−01A−01D−1870−08 TCGA−CN−6011−01A−11D−1683−08 TCGA−BB−7863−01A−11D−2229−08 TCGA−BA−5559−01A−01D−1512−08 TCGA−BA−4076−01A−01D−1434−08 TCGA−BA−4075−01A−01D−1434−08 HN_62672−Tumor HN_62652−Tumor

TCGA−CV−6433−01A−11D−1683−08 TCGA−CV−7406−01A−11D−2078−08 TCGA−CN−4734−01A−01D−1434−08 HN_62481−Tumor TCGA−CQ−5327−01A−01D−1683−08 TCGA−CR−6488−01A−12D−2078−08 HN_62415−Tumor HN_62421−Tumor TCGA−CR−6470−01A−11D−1870−08 TCGA−IQ−7632−01A−11D−2078−08 TCGA−CV−7429−01A−11D−2129−08 TCGA−CR−7401−01A−11D−2012−08 HN_62825−Tumor TCGA−BB−7866−01A−11D−2229−08 TCGA−CV−7407−01A−11D−2078−08 TCGA−CV−7440−01A−11D−2129−08 TCGA−CR−6487−01A−11D−1870−08 TCGA−DQ−5625−01A−01D−1870−08 HN_62672−Tumor HN_62686−Tumor HN_62237−Tumor TCGA−CV−7411−01A−11D−2078−08 TCGA−CV−6938−01A−11D−1912−08 TCGA−CR−5248−01A−01D−2012−08 TCGA−CR−5243−01A−01D−1512−08 TCGA−CV−7427−01A−11D−2078−08 TCGA−CV−7243−01A−11D−2012−08 HN_63021−Tumor TCGA−BB−4223−01A−01D−1434−08 HN_62755−Tumor HN_62318−Tumor TCGA−CV−7250−01A−11D−2012−08 TCGA−CR−7404−01A−11D−2129−08 TCGA−HD−7754−01A−11D−2078−08 TCGA−CR−7395−01A−11D−2012−08 TCGA−CR−7367−01A−11D−2012−08 TCGA−CR−7369−01A−11D−2129−08 TCGA−CN−5355−01A−01D−1434−08 TCGA−CQ−5324−01A−01D−1683−08 TCGA−CN−5369−01A−01D−1434−08 TCGA−BA−5556−01A−01D−1512−08 TCGA−BA−4077−01B−01D−1434−08 HN_62699−Tumor TCGA−CV−6961−01A−21D−1912−08 TCGA−CR−5247−01A−01D−2012−08 TCGA−HD−7753−01A−11D−2078−08 TCGA−DQ−7591−01A−11D−2078−08 TCGA−CV−6941−01A−11D−1912−08 TCGA−CV−5971−01A−11D−1683−08 TCGA−CR−6481−01A−11D−1870−08 TCGA−BA−6871−01A−11D−1870−08 HN_62861−Tumor HN_00076−Tumor TCGA−CV−7414−01A−11D−2078−08 TCGA−CV−7248−01A−11D−2012−08 TCGA−CV−7245−01A−11D−2012−08 TCGA−CV−7235−01A−11D−2012−08 TCGA−CV−7101−01A−11D−2012−08 TCGA−CV−7099−01A−41D−2012−08 TCGA−CV−6950−01A−11D−1912−08 TCGA−CV−6436−01A−11D−1683−08 TCGA−CV−5432−01A−02D−1683−08 TCGA−CV−5430−01A−02D−1683−08 TCGA−CR−7394−01A−11D−2012−08 TCGA−CR−7390−01A−11D−2012−08 TCGA−CR−7386−01A−11D−2012−08 TCGA−CR−7380−01A−11D−2012−08 TCGA−CR−6484−01A−11D−1870−08 TCGA−CQ−6225−01A−11D−1912−08 TCGA−CQ−5332−01A−01D−1683−08 TCGA−CN−6992−01A−11D−1912−08 TCGA−CN−6021−01A−11D−1683−08 TCGA−CN−6013−01A−11D−1683−08 TCGA−CN−4727−01A−01D−1434−08 TCGA−BA−5558−01A−01D−1512−08 HN_63081−Tumor HN_62739−Tumor HN_62646−Tumor HN_62506−Tumor TCGA−HD−7229−01A−11D−2012−08 TCGA−F7−7848−01A−11D−2129−08 TCGA−DQ−7595−01A−11D−2229−08 TCGA−D6−6826−01A−11D−1912−08 TCGA−D6−6823−01A−11D−1912−08 TCGA−CX−7219−01A−11D−2012−08 TCGA−CV−7437−01A−21D−2129−08 TCGA−CV−7435−01A−11D−2129−08 TCGA−CV−7433−01A−11D−2129−08 TCGA−CV−7422−01A−21D−2078−08 TCGA−CV−7418−01A−11D−2078−08 TCGA−CV−7263−01A−11D−2012−08 TCGA−CV−7255−01A−11D−2012−08 TCGA−CV−7252−01A−11D−2012−08 TCGA−CV−7242−01A−11D−2012−08 TCGA−CV−7236−01A−11D−2012−08 TCGA−CV−7104−01A−11D−2012−08 TCGA−CV−7097−01A−11D−2012−08 TCGA−CV−7095−01A−21D−2012−08 TCGA−CV−7091−01A−11D−2012−08 TCGA−CV−7089−01A−11D−2012−08 TCGA−CV−6945−01A−11D−1912−08 TCGA−CV−6942−01A−21D−2012−08 TCGA−CV−6940−01A−11D−1912−08 TCGA−CV−6937−01A−11D−2012−08 TCGA−CV−6934−01A−11D−1912−08 TCGA−CV−5977−01A−11D−1683−08 TCGA−CV−5970−01A−11D−1683−08 TCGA−CV−5966−01A−11D−1683−08 TCGA−CV−5444−01A−02D−1512−08 TCGA−CV−5440−01A−01D−1512−08 TCGA−CV−5439−01A−01D−1683−08 TCGA−CV−5435−01A−01D−1683−08 TCGA−CV−5431−01A−01D−1512−08 TCGA−CR−7399−01A−11D−2012−08 TCGA−CR−7377−01A−11D−2012−08 TCGA−CR−7374−01A−11D−2012−08 TCGA−CR−7371−01A−11D−2012−08 TCGA−CR−7368−01A−11D−2129−08 TCGA−CR−7365−01A−11D−2012−08 TCGA−CR−7364−01A−11D−2012−08 TCGA−CR−6491−01A−11D−1870−08 TCGA−CR−6478−01A−11D−1870−08 TCGA−CR−6477−01A−11D−1870−08 TCGA−CQ−6229−01A−11D−1912−08 TCGA−CQ−6223−01A−11D−1912−08 TCGA−CQ−6219−01A−11D−1912−08 TCGA−CQ−6218−01A−11D−1912−08 TCGA−CQ−5331−01A−02D−1870−08 TCGA−CN−6997−01A−11D−2012−08 TCGA−CN−6996−01A−11D−1912−08 TCGA−CN−6024−01A−11D−1683−08 TCGA−CN−6023−01A−11D−1683−08 TCGA−CN−6020−01A−11D−1683−08 TCGA−CN−6019−01A−11D−1683−08 TCGA−CN−6011−01A−11D−1683−08 TCGA−CN−5373−01A−01D−1434−08 TCGA−CN−5370−01A−01D−2012−08 TCGA−CN−5364−01A−01D−1434−08 TCGA−CN−5360−01A−01D−1434−08 TCGA−CN−5359−01A−01D−1434−08 TCGA−CN−5356−01A−01D−1434−08 TCGA−CN−4739−01A−02D−1512−08 TCGA−CN−4731−01A−01D−1434−08 TCGA−CN−4729−01A−01D−1434−08 TCGA−BB−7871−01A−11D−2229−08 TCGA−BB−7862−01A−21D−2229−08 TCGA−BB−4227−01A−01D−1870−08 TCGA−BB−4224−01A−01D−1434−08 TCGA−BA−6872−01A−11D−1870−08 TCGA−BA−6869−01A−11D−1870−08 TCGA−BA−5555−01A−01D−1512−08 TCGA−BA−5152−01A−02D−1870−08 TCGA−BA−4078−01A−01D−1434−08 TCGA−BA−4076−01A−01D−1434−08 HN_63080−Tumor HN_63058−Tumor HN_63007−Tumor HN_62741−Tumor HN_62652−Tumor HN_62539−Tumor HN_62532−Tumor HN_62432−Tumor HN_62338−Tumor HN_00190−Tumor TCGA−IQ−7630−01A−11D−2078−08 TCGA−HD−7917−01A−11D−2229−08 TCGA−HD−7831−01A−11D−2129−08 TCGA−DQ−7592−01A−11D−2078−08 TCGA−DQ−7588−01A−11D−2078−08 TCGA−DQ−5631−01A−01D−1870−08 TCGA−DQ−5630−01A−01D−1870−08 TCGA−DQ−5629−01A−01D−1870−08 TCGA−DQ−5624−01A−01D−1870−08 TCGA−D6−6825−01A−21D−1912−08 TCGA−D6−6824−01A−11D−1912−08 TCGA−D6−6517−01A−11D−1870−08 TCGA−D6−6515−01A−21D−1870−08 TCGA−CX−7086−01A−11D−2078−08 TCGA−CX−7082−01A−11D−2012−08 TCGA−CV−7438−01A−21D−2129−08 TCGA−CV−7434−01A−11D−2129−08 TCGA−CV−7432−01A−11D−2129−08 TCGA−CV−7430−01A−11D−2129−08 TCGA−CV−7424−01A−11D−2078−08 TCGA−CV−7421−01A−11D−2078−08 TCGA−CV−7416−01A−11D−2078−08 TCGA−CV−7415−01A−11D−2078−08 TCGA−CV−7413−01A−11D−2078−08 TCGA−CV−7409−01A−31D−2229−08 TCGA−CV−7254−01A−11D−2012−08 TCGA−CV−7253−01A−11D−2012−08 TCGA−CV−7247−01A−11D−2012−08 TCGA−CV−7238−01A−11D−2012−08 TCGA−CV−7180−01A−11D−2012−08 TCGA−CV−7177−01A−11D−2012−08 TCGA−CV−7103−01A−21D−2012−08 TCGA−CV−7102−01A−11D−2012−08 TCGA−CV−7090−01A−11D−2012−08 TCGA−CV−6962−01A−11D−1912−08 TCGA−CV−6960−01A−41D−2012−08 TCGA−CV−6959−01A−11D−1912−08 TCGA−CV−6956−01A−21D−2012−08 TCGA−CV−6953−01A−11D−1912−08 TCGA−CV−6952−01A−11D−1912−08 TCGA−CV−6951−01A−11D−1912−08 TCGA−CV−6948−01A−11D−1912−08 TCGA−CV−6943−01A−11D−1912−08 TCGA−CV−6936−01A−11D−1912−08 TCGA−CV−6935−01A−11D−1912−08 TCGA−CV−6933−01A−11D−1912−08 TCGA−CV−6003−01A−11D−1683−08 TCGA−CV−5979−01A−11D−1683−08 TCGA−CV−5978−01A−11D−1683−08 TCGA−CV−5976−01A−11D−1683−08 TCGA−CV−5973−01A−11D−1683−08 TCGA−CV−5436−01A−01D−1512−08 TCGA−CV−5434−01A−01D−1683−08 TCGA−CR−7398−01A−11D−2012−08 TCGA−CR−7397−01A−11D−2012−08 TCGA−CR−7393−01A−11D−2012−08 TCGA−CR−7389−01A−11D−2012−08 TCGA−CR−7383−01A−11D−2129−08 TCGA−CR−7379−01A−11D−2012−08 TCGA−CR−7376−01A−11D−2129−08 TCGA−CR−7372−01A−11D−2012−08 TCGA−CR−7370−01A−11D−2129−08 TCGA−CR−6493−01A−11D−1870−08 TCGA−CR−6474−01A−11D−1870−08 TCGA−CQ−7067−01A−11D−2229−08 TCGA−CQ−7065−01A−11D−2078−08 TCGA−CQ−6228−01A−11D−1912−08 TCGA−CQ−6224−01A−11D−1912−08 TCGA−CQ−6222−01A−11D−1912−08 TCGA−CQ−6221−01A−11D−2078−08 TCGA−CQ−6220−01A−11D−1912−08 TCGA−CQ−5334−01A−01D−1683−08 TCGA−CQ−5330−01A−01D−1683−08 TCGA−CQ−5329−01A−01D−1683−08 TCGA−CQ−5326−01A−01D−1870−08 TCGA−CN−6998−01A−23D−2012−08 TCGA−CN−6995−01A−31D−2012−08 TCGA−CN−6994−01A−11D−1912−08 TCGA−CN−6989−01A−11D−1912−08 TCGA−CN−6988−01A−11D−1912−08 TCGA−CN−6022−01A−21D−1683−08 TCGA−CN−6018−01A−11D−1683−08 TCGA−CN−6017−01A−11D−1683−08 TCGA−CN−6016−01A−11D−1683−08 TCGA−CN−6012−01A−11D−1683−08 TCGA−CN−5367−01A−01D−1434−08 TCGA−CN−5366−01A−01D−1434−08 TCGA−CN−5365−01A−01D−1434−08 TCGA−CN−5363−01A−01D−1434−08 TCGA−CN−4742−01A−02D−1512−08 TCGA−CN−4740−01A−01D−1434−08 TCGA−CN−4738−01A−02D−1512−08 TCGA−CN−4737−01A−01D−1434−08 TCGA−CN−4736−01A−01D−1434−08 TCGA−CN−4735−01A−01D−1434−08 TCGA−CN−4733−01A−02D−1870−08 TCGA−CN−4728−01A−01D−1434−08 TCGA−CN−4726−01A−01D−1434−08 TCGA−CN−4725−01A−01D−1434−08 TCGA−BB−7870−01A−11D−2229−08 TCGA−BB−4217−01A−11D−2078−08 TCGA−BA−7269−01A−11D−2012−08 TCGA−BA−6873−01A−11D−1870−08 TCGA−BA−6870−01A−11D−1870−08 TCGA−BA−6868−01B−12D−1912−08 TCGA−BA−5557−01A−01D−1512−08 TCGA−BA−5151−01A−01D−1434−08 TCGA−BA−4075−01A−01D−1434−08 TCGA−BA−4074−01A−01D−1434−08 HN_63114−Tumor HN_63048−Tumor HN_63039−Tumor HN_62995−Tumor HN_62984−Tumor HN_62926−Tumor HN_62921−Tumor HN_62897−Tumor HN_62857_2−Tumor HN_62832−Tumor HN_62814−Tumor HN_62671−Tumor HN_62601−Tumor HN_62515−Tumor HN_62505−Tumor HN_62493−Tumor HN_62469−Tumor HN_62376−Tumor HN_62332−Tumor HN_62298−Tumor HN_01000−Tumor HN_00443−Tumor HN_00378−Tumor HN_00313−Tumor HN_0−046−Tumor

COL6A6

unknown CG mut

known HCG mut

wt TP53 HERC2 TP53BP1 WHSC1 ATM BRCA1 HIST1H2BF HIST1H2BH HIST1H2BK HIST1H4C HIST1H4E KDM4A NBN APBB1 CHEK2 EYA1 EYA4 HIST1H2BG HIST1H2BI HIST1H2BL HIST1H2BM HIST1H4D HIST1H4F HIST1H4H HIST4H4 KDM4B MRE11A PPP5C RAD50 BARD1 BAZ1B BRE EYA2 EYA3 FAM175A HIST1H2BB HIST1H2BD HIST1H2BE HIST1H2BJ HIST1H2BN HIST1H4B HIST1H4I HIST1H4K HIST1H4L HIST2H2BE KAT5 MAPK8 MDC1 PIAS4 RNF168 RPS27A SMARCA5 UBA52 UBC UBE2I UIMC1

wt COL6A2


TCGA−CV−7425−01A−11D−2078−08 HN_62863−Tumor TCGA−CX−7219−01A−11D−2012−08 TCGA−CR−7386−01A−11D−2012−08 HN_00761−Tumor TCGA−CR−7368−01A−11D−2129−08 HN_00076−Tumor HN_63080−Tumor TCGA−CV−5440−01A−01D−1512−08 TCGA−CX−7085−01A−21D−2012−08 TCGA−CR−6471−01A−11D−1870−08 TCGA−CX−7082−01A−11D−2012−08 TCGA−CN−5369−01A−01D−1434−08 TCGA−DQ−7595−01A−11D−2229−08 TCGA−CN−4739−01A−02D−1512−08 TCGA−CV−7438−01A−21D−2129−08 TCGA−CV−7178−01A−21D−2012−08 TCGA−BB−4227−01A−01D−1870−08 TCGA−F7−7848−01A−11D−2129−08 TCGA−CV−6441−01A−11D−1683−08 TCGA−CN−4729−01A−01D−1434−08 TCGA−HD−7229−01A−11D−2012−08 TCGA−D6−6517−01A−11D−1870−08 HN_62532−Tumor TCGA−DQ−5624−01A−01D−1870−08 TCGA−CN−6998−01A−23D−2012−08 TCGA−CN−6018−01A−11D−1683−08 TCGA−CN−5370−01A−01D−2012−08 TCGA−CR−5248−01A−01D−2012−08 TCGA−CR−7370−01A−11D−2129−08 TCGA−CR−5250−01A−01D−1512−08 HN_62921−Tumor TCGA−CV−7427−01A−11D−2078−08 TCGA−DQ−5629−01A−01D−1870−08 TCGA−CV−6945−01A−11D−1912−08 TCGA−CN−6011−01A−11D−1683−08 TCGA−BB−4225−01A−01D−1434−08 HN_62814−Tumor TCGA−CV−7433−01A−11D−2129−08 TCGA−CV−6961−01A−21D−1912−08 TCGA−CV−6954−01A−11D−1912−08 TCGA−BB−4228−01A−01D−1434−08 TCGA−CN−6013−01A−11D−1683−08 TCGA−CV−7099−01A−41D−2012−08 TCGA−CV−6933−01A−11D−1912−08 TCGA−CV−5434−01A−01D−1683−08 TCGA−BA−4076−01A−01D−1434−08 HN_00378−Tumor TCGA−CV−6938−01A−11D−1912−08 TCGA−CV−6935−01A−11D−1912−08 TCGA−CV−7440−01A−11D−2129−08 TCGA−CV−5442−01A−01D−1512−08 TCGA−CN−6997−01A−11D−2012−08 TCGA−CN−6022−01A−21D−1683−08 TCGA−CV−6955−01A−11D−2012−08 TCGA−CV−5435−01A−01D−1683−08 TCGA−CR−6474−01A−11D−1870−08 TCGA−CN−6995−01A−31D−2012−08 TCGA−CN−6020−01A−11D−1683−08 TCGA−CN−4735−01A−01D−1434−08 HN_62699−Tumor TCGA−CR−7399−01A−11D−2012−08 TCGA−CR−6481−01A−11D−1870−08 TCGA−BA−6868−01B−12D−1912−08 HN_62854−Tumor HN_62739−Tumor TCGA−CV−7416−01A−11D−2078−08 TCGA−CV−7101−01A−11D−2012−08 TCGA−CV−5432−01A−02D−1683−08 TCGA−CR−5247−01A−01D−2012−08 TCGA−BB−4223−01A−01D−1434−08 HN_62897−Tumor TCGA−BA−4078−01A−01D−1434−08 TCGA−CR−7364−01A−11D−2012−08 TCGA−CN−6992−01A−11D−1912−08 TCGA−CV−6956−01A−21D−2012−08 TCGA−BA−6869−01A−11D−1870−08 TCGA−BA−5559−01A−01D−1512−08 HN_62506−Tumor TCGA−CV−7248−01A−11D−2012−08 TCGA−CV−6960−01A−41D−2012−08 TCGA−CR−6491−01A−11D−1870−08 TCGA−CR−6487−01A−11D−1870−08 TCGA−CN−5361−01A−01D−1434−08 TCGA−BB−7871−01A−11D−2229−08 HN_62672−Tumor HN_62237−Tumor TCGA−CQ−6220−01A−11D−1912−08 TCGA−CN−6021−01A−11D−1683−08 TCGA−BA−4077−01B−01D−1434−08 HN_62861−Tumor TCGA−CV−7250−01A−11D−2012−08 TCGA−CV−5978−01A−11D−1683−08 TCGA−D6−6825−01A−21D−1912−08 TCGA−CX−7086−01A−11D−2078−08 TCGA−CV−7418−01A−11D−2078−08 TCGA−CV−7238−01A−11D−2012−08 TCGA−CQ−6223−01A−11D−1912−08 TCGA−CN−6024−01A−11D−1683−08 TCGA−CN−6019−01A−11D−1683−08 TCGA−CN−6012−01A−11D−1683−08 TCGA−BB−4224−01A−01D−1434−08 TCGA−BA−4074−01A−01D−1434−08 HN_62515−Tumor HN_62432−Tumor HN_62415−Tumor HN_62298−Tumor

Recruitment And ATM Mediated Phosphorylation Of Repair And Signaling Proteins At DNA Double Strand Breaks FDR = 1.9e−12%, FDR nod = 0.028%

unknown CG mut

COL6A3

COL4A4 THBS1

known HCG mut

COL4A5 PLG

known HCG mut

THBS2

PDGFRB

wt

COL4A2

COL4A3

COL9A2

COL6A5 PDGFD

PDGFRA COL6A1

COL9A1

COL9A3 FURIN

PDGFA PLAT

SPP1

THBS3

PDGFB

PDGFC THBS4


COL4A1

unknown CG mut


Signaling By PDGF FDR = 0.65%, FDR nod = 3.1%

TCGA−CV−6433−01A−11D−1683−08 TCGA−CV−7406−01A−11D−2078−08 TCGA−CN−4734−01A−01D−1434−08 HN_62481−Tumor TCGA−CQ−5327−01A−01D−1683−08 TCGA−CR−6488−01A−12D−2078−08 HN_62415−Tumor HN_62421−Tumor TCGA−CR−6470−01A−11D−1870−08 TCGA−IQ−7632−01A−11D−2078−08 TCGA−CV−7429−01A−11D−2129−08 TCGA−CR−7401−01A−11D−2012−08 HN_62825−Tumor TCGA−BB−7866−01A−11D−2229−08 TCGA−CV−7407−01A−11D−2078−08 TCGA−CV−7440−01A−11D−2129−08 TCGA−CR−6487−01A−11D−1870−08 TCGA−DQ−5625−01A−01D−1870−08 HN_62672−Tumor HN_62686−Tumor HN_62237−Tumor TCGA−CV−7411−01A−11D−2078−08 TCGA−CV−6938−01A−11D−1912−08 TCGA−CR−5248−01A−01D−2012−08 TCGA−CR−5243−01A−01D−1512−08 TCGA−CV−7427−01A−11D−2078−08 TCGA−CV−7243−01A−11D−2012−08 HN_63021−Tumor TCGA−BB−4223−01A−01D−1434−08 HN_62755−Tumor HN_62318−Tumor TCGA−CV−7250−01A−11D−2012−08 TCGA−CR−7404−01A−11D−2129−08 TCGA−HD−7754−01A−11D−2078−08 TCGA−CR−7395−01A−11D−2012−08 TCGA−CR−7367−01A−11D−2012−08 TCGA−CR−7369−01A−11D−2129−08 TCGA−CN−5355−01A−01D−1434−08 TCGA−CQ−5324−01A−01D−1683−08 TCGA−CN−5369−01A−01D−1434−08 TCGA−BA−5556−01A−01D−1512−08 TCGA−BA−4077−01B−01D−1434−08 HN_62699−Tumor TCGA−CV−6961−01A−21D−1912−08 TCGA−CR−5247−01A−01D−2012−08 TCGA−HD−7753−01A−11D−2078−08 TCGA−DQ−7591−01A−11D−2078−08 TCGA−CV−6941−01A−11D−1912−08 TCGA−CV−5971−01A−11D−1683−08 TCGA−CR−6481−01A−11D−1870−08 TCGA−BA−6871−01A−11D−1870−08 HN_62861−Tumor HN_00076−Tumor TCGA−CV−7414−01A−11D−2078−08 TCGA−CV−7248−01A−11D−2012−08 TCGA−CV−7245−01A−11D−2012−08 TCGA−CV−7235−01A−11D−2012−08 TCGA−CV−7101−01A−11D−2012−08 TCGA−CV−7099−01A−41D−2012−08 TCGA−CV−6950−01A−11D−1912−08 TCGA−CV−6436−01A−11D−1683−08 TCGA−CV−5432−01A−02D−1683−08 TCGA−CV−5430−01A−02D−1683−08 TCGA−CR−7394−01A−11D−2012−08 TCGA−CR−7390−01A−11D−2012−08 TCGA−CR−7386−01A−11D−2012−08 TCGA−CR−7380−01A−11D−2012−08 TCGA−CR−6484−01A−11D−1870−08 TCGA−CQ−6225−01A−11D−1912−08 TCGA−CQ−5332−01A−01D−1683−08 TCGA−CN−6992−01A−11D−1912−08 TCGA−CN−6021−01A−11D−1683−08 TCGA−CN−6013−01A−11D−1683−08 TCGA−CN−4727−01A−01D−1434−08 TCGA−BA−5558−01A−01D−1512−08 HN_63081−Tumor HN_62739−Tumor HN_62646−Tumor HN_62506−Tumor TCGA−HD−7229−01A−11D−2012−08 TCGA−F7−7848−01A−11D−2129−08 TCGA−DQ−7595−01A−11D−2229−08 TCGA−D6−6826−01A−11D−1912−08 TCGA−D6−6823−01A−11D−1912−08 TCGA−CX−7219−01A−11D−2012−08 TCGA−CV−7437−01A−21D−2129−08 TCGA−CV−7435−01A−11D−2129−08 TCGA−CV−7433−01A−11D−2129−08 TCGA−CV−7422−01A−21D−2078−08 TCGA−CV−7418−01A−11D−2078−08 TCGA−CV−7263−01A−11D−2012−08 TCGA−CV−7255−01A−11D−2012−08 TCGA−CV−7252−01A−11D−2012−08 TCGA−CV−7242−01A−11D−2012−08 TCGA−CV−7236−01A−11D−2012−08 TCGA−CV−7104−01A−11D−2012−08 TCGA−CV−7097−01A−11D−2012−08 TCGA−CV−7095−01A−21D−2012−08 TCGA−CV−7091−01A−11D−2012−08 TCGA−CV−7089−01A−11D−2012−08 TCGA−CV−6945−01A−11D−1912−08 TCGA−CV−6942−01A−21D−2012−08 TCGA−CV−6940−01A−11D−1912−08 TCGA−CV−6937−01A−11D−2012−08 TCGA−CV−6934−01A−11D−1912−08 TCGA−CV−5977−01A−11D−1683−08 TCGA−CV−5970−01A−11D−1683−08 TCGA−CV−5966−01A−11D−1683−08 TCGA−CV−5444−01A−02D−1512−08 TCGA−CV−5440−01A−01D−1512−08 TCGA−CV−5439−01A−01D−1683−08 TCGA−CV−5435−01A−01D−1683−08 TCGA−CV−5431−01A−01D−1512−08 TCGA−CR−7399−01A−11D−2012−08 TCGA−CR−7377−01A−11D−2012−08 TCGA−CR−7374−01A−11D−2012−08 TCGA−CR−7371−01A−11D−2012−08 TCGA−CR−7368−01A−11D−2129−08 TCGA−CR−7365−01A−11D−2012−08 TCGA−CR−7364−01A−11D−2012−08 TCGA−CR−6491−01A−11D−1870−08 TCGA−CR−6478−01A−11D−1870−08 TCGA−CR−6477−01A−11D−1870−08 TCGA−CQ−6229−01A−11D−1912−08 TCGA−CQ−6223−01A−11D−1912−08 TCGA−CQ−6219−01A−11D−1912−08 TCGA−CQ−6218−01A−11D−1912−08 TCGA−CQ−5331−01A−02D−1870−08 TCGA−CN−6997−01A−11D−2012−08 TCGA−CN−6996−01A−11D−1912−08 TCGA−CN−6024−01A−11D−1683−08 TCGA−CN−6023−01A−11D−1683−08 TCGA−CN−6020−01A−11D−1683−08 TCGA−CN−6019−01A−11D−1683−08 TCGA−CN−6011−01A−11D−1683−08 TCGA−CN−5373−01A−01D−1434−08 TCGA−CN−5370−01A−01D−2012−08 TCGA−CN−5364−01A−01D−1434−08 TCGA−CN−5360−01A−01D−1434−08 TCGA−CN−5359−01A−01D−1434−08 TCGA−CN−5356−01A−01D−1434−08 TCGA−CN−4739−01A−02D−1512−08 TCGA−CN−4731−01A−01D−1434−08 TCGA−CN−4729−01A−01D−1434−08 TCGA−BB−7871−01A−11D−2229−08 TCGA−BB−7862−01A−21D−2229−08 TCGA−BB−4227−01A−01D−1870−08 TCGA−BB−4224−01A−01D−1434−08 TCGA−BA−6872−01A−11D−1870−08 TCGA−BA−6869−01A−11D−1870−08 TCGA−BA−5555−01A−01D−1512−08 TCGA−BA−5152−01A−02D−1870−08 TCGA−BA−4078−01A−01D−1434−08 TCGA−BA−4076−01A−01D−1434−08 HN_63080−Tumor HN_63058−Tumor HN_63007−Tumor HN_62741−Tumor HN_62652−Tumor HN_62539−Tumor HN_62532−Tumor HN_62432−Tumor HN_62338−Tumor HN_00190−Tumor TCGA−IQ−7630−01A−11D−2078−08 TCGA−HD−7917−01A−11D−2229−08 TCGA−HD−7831−01A−11D−2129−08 TCGA−DQ−7592−01A−11D−2078−08 TCGA−DQ−7588−01A−11D−2078−08 TCGA−DQ−5631−01A−01D−1870−08 TCGA−DQ−5630−01A−01D−1870−08 TCGA−DQ−5629−01A−01D−1870−08 TCGA−DQ−5624−01A−01D−1870−08 TCGA−D6−6825−01A−21D−1912−08 TCGA−D6−6824−01A−11D−1912−08 TCGA−D6−6517−01A−11D−1870−08 TCGA−D6−6515−01A−21D−1870−08 TCGA−CX−7086−01A−11D−2078−08 TCGA−CX−7082−01A−11D−2012−08 TCGA−CV−7438−01A−21D−2129−08 TCGA−CV−7434−01A−11D−2129−08 TCGA−CV−7432−01A−11D−2129−08 TCGA−CV−7430−01A−11D−2129−08 TCGA−CV−7424−01A−11D−2078−08 TCGA−CV−7421−01A−11D−2078−08 TCGA−CV−7416−01A−11D−2078−08 TCGA−CV−7415−01A−11D−2078−08 TCGA−CV−7413−01A−11D−2078−08 TCGA−CV−7409−01A−31D−2229−08 TCGA−CV−7254−01A−11D−2012−08 TCGA−CV−7253−01A−11D−2012−08 TCGA−CV−7247−01A−11D−2012−08 TCGA−CV−7238−01A−11D−2012−08 TCGA−CV−7180−01A−11D−2012−08 TCGA−CV−7177−01A−11D−2012−08 TCGA−CV−7103−01A−21D−2012−08 TCGA−CV−7102−01A−11D−2012−08 TCGA−CV−7090−01A−11D−2012−08 TCGA−CV−6962−01A−11D−1912−08 TCGA−CV−6960−01A−41D−2012−08 TCGA−CV−6959−01A−11D−1912−08 TCGA−CV−6956−01A−21D−2012−08 TCGA−CV−6953−01A−11D−1912−08 TCGA−CV−6952−01A−11D−1912−08 TCGA−CV−6951−01A−11D−1912−08 TCGA−CV−6948−01A−11D−1912−08 TCGA−CV−6943−01A−11D−1912−08 TCGA−CV−6936−01A−11D−1912−08 TCGA−CV−6935−01A−11D−1912−08 TCGA−CV−6933−01A−11D−1912−08 TCGA−CV−6003−01A−11D−1683−08 TCGA−CV−5979−01A−11D−1683−08 TCGA−CV−5978−01A−11D−1683−08 TCGA−CV−5976−01A−11D−1683−08 TCGA−CV−5973−01A−11D−1683−08 TCGA−CV−5436−01A−01D−1512−08 TCGA−CV−5434−01A−01D−1683−08 TCGA−CR−7398−01A−11D−2012−08 TCGA−CR−7397−01A−11D−2012−08 TCGA−CR−7393−01A−11D−2012−08 TCGA−CR−7389−01A−11D−2012−08 TCGA−CR−7383−01A−11D−2129−08 TCGA−CR−7379−01A−11D−2012−08 TCGA−CR−7376−01A−11D−2129−08 TCGA−CR−7372−01A−11D−2012−08 TCGA−CR−7370−01A−11D−2129−08 TCGA−CR−6493−01A−11D−1870−08 TCGA−CR−6474−01A−11D−1870−08 TCGA−CQ−7067−01A−11D−2229−08 TCGA−CQ−7065−01A−11D−2078−08 TCGA−CQ−6228−01A−11D−1912−08 TCGA−CQ−6224−01A−11D−1912−08 TCGA−CQ−6222−01A−11D−1912−08 TCGA−CQ−6221−01A−11D−2078−08 TCGA−CQ−6220−01A−11D−1912−08 TCGA−CQ−5334−01A−01D−1683−08 TCGA−CQ−5330−01A−01D−1683−08 TCGA−CQ−5329−01A−01D−1683−08 TCGA−CQ−5326−01A−01D−1870−08 TCGA−CN−6998−01A−23D−2012−08 TCGA−CN−6995−01A−31D−2012−08 TCGA−CN−6994−01A−11D−1912−08 TCGA−CN−6989−01A−11D−1912−08 TCGA−CN−6988−01A−11D−1912−08 TCGA−CN−6022−01A−21D−1683−08 TCGA−CN−6018−01A−11D−1683−08 TCGA−CN−6017−01A−11D−1683−08 TCGA−CN−6016−01A−11D−1683−08 TCGA−CN−6012−01A−11D−1683−08 TCGA−CN−5367−01A−01D−1434−08 TCGA−CN−5366−01A−01D−1434−08 TCGA−CN−5365−01A−01D−1434−08 TCGA−CN−5363−01A−01D−1434−08 TCGA−CN−4742−01A−02D−1512−08 TCGA−CN−4740−01A−01D−1434−08 TCGA−CN−4738−01A−02D−1512−08 TCGA−CN−4737−01A−01D−1434−08 TCGA−CN−4736−01A−01D−1434−08 TCGA−CN−4735−01A−01D−1434−08 TCGA−CN−4733−01A−02D−1870−08 TCGA−CN−4728−01A−01D−1434−08 TCGA−CN−4726−01A−01D−1434−08 TCGA−CN−4725−01A−01D−1434−08 TCGA−BB−7870−01A−11D−2229−08 TCGA−BB−4217−01A−11D−2078−08 TCGA−BA−7269−01A−11D−2012−08 TCGA−BA−6873−01A−11D−1870−08 TCGA−BA−6870−01A−11D−1870−08 TCGA−BA−6868−01B−12D−1912−08 TCGA−BA−5557−01A−01D−1512−08 TCGA−BA−5151−01A−01D−1434−08 TCGA−BA−4075−01A−01D−1434−08 TCGA−BA−4074−01A−01D−1434−08 HN_63114−Tumor HN_63048−Tumor HN_63039−Tumor HN_62995−Tumor HN_62984−Tumor HN_62926−Tumor HN_62921−Tumor HN_62897−Tumor HN_62857_2−Tumor HN_62832−Tumor HN_62814−Tumor HN_62671−Tumor HN_62601−Tumor HN_62515−Tumor HN_62505−Tumor HN_62493−Tumor HN_62469−Tumor HN_62376−Tumor HN_62332−Tumor HN_62298−Tumor HN_01000−Tumor HN_00443−Tumor HN_00378−Tumor HN_00313−Tumor HN_0−046−Tumor

KIRC

DNA Damage/Telomere Stress Induced Senescence FDR = 0.14%, FDR nod = 1.9% Regulation Of IFNA Signaling FDR = 1.1%, FDR nod = 2.1%

TCGA−CZ−5458−01A−01D−1501−10 TCGA−BP−4352−01A−01D−1366−10 TCGA−A3−3363−01A−01D−0966−08 TCGA−B0−5113−01A−01D−1421−08 TCGA−CW−5588−01A−01D−1534−10 TCGA−B8−4143−01A−01D−1806−10 TCGA−A3−3322−01 TCGA−B0−5119−01A−02D−1421−08 TCGA−A3−3382−01A−01D−0966−08 TCGA−CZ−5453−01A−01D−1501−10 TCGA−A3−3362−01A−02D−1386−10 TCGA−B0−4845−01 TCGA−A3−3372−01A−01D−0966−08 TCGA−CJ−6028−01A−11D−1669−08 TCGA−B0−5713−01A−11D−1669−08 TCGA−EU−5905−01A−11D−1669−08 TCGA−B8−4621−01 TCGA−A3−3317−01A−01D−0966−08 TCGA−CZ−4862−01A−01D−1373−10 TCGA−CJ−4912−01A−01D−1429−08 TCGA−B0−4691−01A−01D−1361−10 TCGA−CJ−4878−01A−01D−1373−10 TCGA−AK−3445−01 TCGA−AK−3434−01A−02D−1361−10 TCGA−A3−3320−01A−01D−0966−08 TCGA−CZ−4857−01A−01D−1373−10 TCGA−CJ−4882−01A−02D−1429−08 TCGA−BP−4983−01A−01D−1462−08 TCGA−B0−5698−01A−11D−1669−08 TCGA−B0−4718−01A−01D−1361−10 TCGA−CZ−4865−01A−02D−1501−10 TCGA−B0−4710−01 TCGA−CZ−5463−01A−01D−1501−10 TCGA−CZ−4858−01 TCGA−CJ−5677−01A−11D−1534−10 TCGA−BP−4798−01 TCGA−BP−4770−01A−01D−1501−10 TCGA−BP−4176−01A−02D−1366−10 TCGA−B0−4703−01 TCGA−CZ−5986−01A−11D−1669−08 TCGA−CZ−5451−01A−01D−1501−10 TCGA−CZ−4861−01A−01D−1373−10 TCGA−CJ−5686−01A−11D−1669−08 TCGA−CJ−4904−01A−02D−1429−08 TCGA−CJ−4639−01A−02D−1386−10 TCGA−BP−5173−01A−01D−1429−08 TCGA−BP−4964−01A−01D−1462−08 TCGA−B8−4622−01 TCGA−B0−5703−01A−11D−1534−10 TCGA−B0−5097−01A−01D−1421−08 TCGA−B0−4690−01

TCGA−B0−5106−01A−01D−1421−08 TCGA−B0−5115−01A−01D−1421−08 TCGA−BP−4352−01A−01D−1366−10 TCGA−AK−3431−01A−02D−1361−10 TCGA−BP−5008−01 TCGA−BP−5176−01A−01D−1429−08 TCGA−CJ−6028−01A−11D−1669−08 TCGA−CJ−6033−01A−11D−1669−08 TCGA−BP−4787−01A−01D−1373−10 TCGA−B0−4822−01 TCGA−CZ−5460−01A−01D−1501−10 TCGA−BP−4355−01 TCGA−BP−4354−01A−02D−1366−10 TCGA−B0−4852−01A−01D−1501−10 TCGA−B0−4844−01A−01D−1361−10 TCGA−BP−4985−01A−01D−1462−08 TCGA−BP−4756−01A−01D−1366−10 TCGA−B0−5097−01A−01D−1421−08 TCGA−CZ−5458−01A−01D−1501−10 TCGA−BP−4782−01 TCGA−AK−3434−01A−02D−1361−10 TCGA−CJ−5676−01A−11D−1534−10 TCGA−CJ−5671−01A−11D−1534−10 TCGA−AK−3454−01A−02D−1361−10 TCGA−BP−4987−01A−01D−1462−08 TCGA−CZ−4859−01A−02D−1429−08 TCGA−B0−4845−01 TCGA−BP−4804−01A−02D−1373−10 TCGA−BP−4777−01A−01D−1366−10 TCGA−B0−5399−01 TCGA−AK−3445−01

TCGA−BP−5195−01A−02D−1429−08 TCGA−A3−3346−01A−01D−0966−08 TCGA−A3−3387−01A−01D−1534−10 TCGA−B0−5402−01A−01D−1501−10 TCGA−CJ−4905−01A−02D−1429−08 TCGA−B0−4844−01A−01D−1361−10 TCGA−B8−5164−01 TCGA−B0−5094−01A−01D−1421−08 TCGA−B0−4823−01A−02D−1421−08 TCGA−CW−6087−01A−11D−1669−08 TCGA−BP−4768−01A−01D−1366−10 TCGA−BP−5010−01A−02D−1421−08 TCGA−B0−4817−01A−01D−1361−10 TCGA−CZ−5458−01A−01D−1501−10 TCGA−CJ−4918−01A−01D−1429−08 TCGA−BP−4352−01A−01D−1366−10 TCGA−A3−3363−01A−01D−0966−08 TCGA−B0−5113−01A−01D−1421−08 TCGA−B8−4143−01A−01D−1806−10 TCGA−BP−4775−01A−01D−1366−10 TCGA−CJ−6030−01A−11D−1669−08 TCGA−A3−3382−01A−01D−0966−08 TCGA−CW−6093−01A−11D−1669−08 TCGA−B0−5691−01A−11D−1534−10 TCGA−AK−3431−01A−02D−1361−10 TCGA−BP−4166−01 TCGA−B0−4814−01A−01D−1361−10 TCGA−BP−4801−01A−02D−1421−08 TCGA−AK−3444−01A−01D−0966−08 TCGA−CW−5591−01A−01D−1534−10 TCGA−A3−3357−01A−02D−1421−08 TCGA−B0−4845−01 TCGA−A3−3372−01A−01D−0966−08 TCGA−CZ−5462−01A−01D−1501−10 TCGA−BP−4766−01A−01D−1366−10 TCGA−CZ−4862−01A−01D−1373−10 TCGA−CJ−4912−01A−01D−1429−08 TCGA−B0−4691−01A−01D−1361−10 TCGA−CZ−5453−01A−01D−1501−10 TCGA−BP−5170−01A−01D−1429−08 TCGA−BP−4337−01A−01D−1366−10 TCGA−CZ−5457−01 TCGA−CJ−4637−01A−02D−1386−10 TCGA−B0−5692−01A−11D−1534−10 TCGA−CJ−4878−01A−01D−1373−10 TCGA−AK−3445−01 TCGA−AK−3434−01A−02D−1361−10 TCGA−CZ−5465−01A−01D−1806−10 TCGA−CJ−4882−01A−02D−1429−08 TCGA−B8−4621−01 TCGA−CJ−4643−01A−02D−1386−10 TCGA−BP−4998−01A−01D−1462−08 TCGA−BP−4160−01A−02D−1366−10 TCGA−CZ−5982−01A−11D−1669−08 TCGA−BP−4163−01 TCGA−B0−5713−01A−11D−1669−08 TCGA−B0−4846−01A−01D−1361−10 TCGA−A3−3320−01A−01D−0966−08 TCGA−CJ−4893−01A−01D−1373−10 TCGA−BP−5185−01A−01D−1429−08 TCGA−B0−5107−01 TCGA−CZ−4853−01A−01D−1429−08 TCGA−CW−5588−01A−01D−1534−10 TCGA−CJ−4923−01A−01D−1429−08 TCGA−B0−5710−01A−11D−1669−08 TCGA−B0−4819−01A−01D−1361−10 TCGA−B0−5096−01A−01D−1421−08 TCGA−B0−4824−01 TCGA−AK−3425−01A−02D−1361−10 TCGA−CZ−5459−01A−01D−1501−10 TCGA−BP−5004−01A−01D−1462−08 TCGA−B8−5545−01A−01D−1669−08 TCGA−CZ−4865−01A−02D−1501−10 TCGA−CZ−5463−01A−01D−1501−10 TCGA−CZ−4858−01 TCGA−CJ−5677−01A−11D−1534−10 TCGA−BP−4798−01 TCGA−BP−4770−01A−01D−1501−10 TCGA−B0−4710−01 TCGA−B0−4703−01 TCGA−BP−4176−01A−02D−1366−10 TCGA−AK−3450−01 TCGA−CZ−4857−01A−01D−1373−10 TCGA−CJ−5682−01A−11D−1534−10 TCGA−CJ−5680−01A−11D−1534−10 TCGA−B0−5695−01 TCGA−B0−4818−01A−01D−1501−10 TCGA−AK−3458−01A−01D−1501−10 TCGA−A3−3317−01A−01D−0966−08 TCGA−BP−4964−01A−01D−1462−08 TCGA−CZ−5986−01A−11D−1669−08 TCGA−CZ−4861−01A−01D−1373−10 TCGA−CJ−4904−01A−02D−1429−08 TCGA−B8−4622−01 TCGA−B0−5097−01A−01D−1421−08 TCGA−CZ−5451−01A−01D−1501−10 TCGA−CJ−5686−01A−11D−1669−08 TCGA−CJ−4639−01A−02D−1386−10 TCGA−BP−5173−01A−01D−1429−08 TCGA−B0−5703−01A−11D−1534−10 TCGA−B0−4690−01

TCGA−CJ−4876−01A−01D−1373−10 TCGA−B0−4818−01A−01D−1501−10 TCGA−BP−4804−01A−02D−1373−10 TCGA−B0−5703−01A−11D−1534−10 TCGA−CZ−4857−01A−01D−1373−10 TCGA−CJ−4882−01A−02D−1429−08 TCGA−BP−4983−01A−01D−1462−08 TCGA−B0−5698−01A−11D−1669−08 TCGA−B0−4718−01A−01D−1361−10 TCGA−CZ−5462−01A−01D−1501−10 TCGA−CJ−4875−01A−01D−1373−10 TCGA−BP−5185−01A−01D−1429−08 TCGA−B0−5707−01A−11D−1534−10 TCGA−B0−5702−01A−11D−1534−10 TCGA−B0−5399−01 TCGA−B0−5119−01A−02D−1421−08 TCGA−CZ−5468−01A−01D−1501−10 TCGA−CZ−4862−01A−01D−1373−10 TCGA−BP−5199−01A−01D−1429−08 TCGA−BP−4347−01A−01D−1366−10 TCGA−BP−4346−01A−01D−1366−10 TCGA−AK−3445−01 TCGA−BP−4770−01A−01D−1501−10 TCGA−CZ−5463−01A−01D−1501−10 TCGA−CZ−4865−01A−02D−1501−10 TCGA−CZ−4858−01 TCGA−CJ−5677−01A−11D−1534−10 TCGA−BP−4798−01 TCGA−BP−4176−01A−02D−1366−10 TCGA−B0−4710−01 TCGA−B0−4703−01

wt wt CDC25C

known HCG mut known HCG mut TNKS1BP1

TP53 JAK1

RAD50 STAT2

TINF2 TYK2

POT1 IFNA1

IFNB1

CDK2 IFNA14

CDKN1A

HIST1H2BM IFNA21

HIST1H2BO IFNA5

HIST1H4E IFNA8

H2AFZ PTPN1

KAT5 PTPN11

G2/M DNA Damage Checkpoint Processing Of DNA Double Strand Break Ends FDR = 0.97%, FDR nod = 2.1%

Formation Of Senescence Associated Heterochromatin Foci (SAHF) FDR = 0.97%, FDR nod = 2.1%

unknown CG mut TP53

known HCG mut

CABIN1

wt

wt

TP53 Regulates Transcription Of Genes Involved In G2 Cell Cycle Arrest FDR = 1%, FDR nod = 2.1% TP53 Regulates Transcription Of Additional Cell Cycle Genes Whose Exact Role In The P53 Pathway Remain Uncertain FDR = 0.67%, FDR nod = 0.97%


EP300 CNOT11

TFDP2 CENPJ

CNOT2

CDC25C

CNOT3

CNOT4

RBL2

CNOT6

RQCD1

BTG2

CNOT8

PCNA

PLK3

RGCC

ZNF385A

wt

EP400

HIST1H1A

HIST1H1C

CDKN1A

LMNB1

RB1

wt ACD USP18

unknown CG mut

known HCG mut

ATM HERC2 TP53 TP53BP1 BLM ATR TOPBP1 BRCA1 BRIP1 CCNA1 CHEK2 CLSPN RAD50 BARD1 NBN RNF4 TOP3A UIMC1 ATRIP BRCC3 BRE CDK2 DNA2 EXO1 HIST1H2BJ HIST1H2BO HIST1H4E HIST1H4H HUS1 KAT5 PPP4C RAD17 RFC2 RFC4 RMI1 RMI2 RPA2 RPS27A SIRT6 TIMELESS UBC UBE2N HIST1H2BM RFC5 WHSC1 WRN

UBN1

ATM STAT1

known HCG mut CCNA1 known HCG mut PTPN6


EP400

NBN

IFNA16

HIST1H2AJ

HIST1H2BJ

IFNAR1

HIST1H4H CCNE1

TP53

CNOT1

TP53

TCGA−CZ−5470−01A−01D−1501−10

TCGA−B8−4148−01A−02D−1386−10

TCGA−CJ−4918−01A−01D−1429−08

TCGA−CJ−4639−01A−02D−1386−10

TCGA−A3−3387−01A−01D−1534−10

TCGA−BP−5192−01A−01D−1429−08

TCGA−CJ−4913−01A−01D−1429−08

TCGA−BP−4761−01A−01D−1366−10

TCGA−BP−4338−01A−01D−1806−10

TCGA−B0−5075−01

TCGA−A3−3373−01A−02D−1421−08

TCGA−CZ−4859−01A−02D−1429−08

TCGA−CJ−6030−01A−11D−1669−08

TCGA−B8−5158−01A−01D−1421−08

TCGA−B0−5713−01A−11D−1669−08

TCGA−B0−4811−01A−01D−1501−10

TCGA−A3−3378−01A−01D−0966−08

TCGA−CZ−4858−01

TCGA−CZ−5463−01A−01D−1501−10

TCGA−CZ−4865−01A−02D−1501−10

TCGA−CJ−5677−01A−11D−1534−10

TCGA−BP−4798−01

TCGA−BP−4770−01A−01D−1501−10

TCGA−BP−4176−01A−02D−1366−10

TCGA−B0−4710−01

TCGA−B0−4703−01

TCGA−CJ−4640−01A−02D−1386−10 TCGA−B8−5549−01A−01D−1534−10 TCGA−BP−5176−01A−01D−1429−08 TCGA−BP−5202−01A−02D−1429−08 TCGA−CZ−5461−01A−01D−1501−10 TCGA−BP−5200−01 TCGA−B2−3924−01 TCGA−B0−5703−01A−11D−1534−10 TCGA−CJ−4907−01A−01D−1429−08 TCGA−B2−4098−01 TCGA−BP−4351−01A−01D−1366−10 TCGA−B0−4847−01A−01D−1361−10 TCGA−CZ−5465−01A−01D−1806−10 TCGA−B0−5100−01A−01D−1421−08 TCGA−BP−4998−01A−01D−1462−08 TCGA−B0−4694−01A−01D−1361−10 TCGA−BP−5192−01A−01D−1429−08 TCGA−A3−3387−01A−01D−1534−10 TCGA−CZ−5987−01A−11D−1669−08 TCGA−CW−6090−01A−11D−1669−08 TCGA−B8−4151−01A−01D−1806−10 TCGA−CJ−5684−01A−11D−1534−10 TCGA−CJ−5679−01 TCGA−BP−4960−01A−01D−1462−08 TCGA−B0−4827−01A−02D−1421−08 TCGA−A3−3378−01A−01D−0966−08 TCGA−A3−3320−01A−01D−0966−08 TCGA−CZ−5458−01A−01D−1501−10 TCGA−CZ−5451−01A−01D−1501−10 TCGA−CJ−4638−01A−02D−1386−10 TCGA−BP−5185−01A−01D−1429−08 TCGA−B8−5159−01A−01D−1421−08 TCGA−B0−5099−01A−01D−1421−08 TCGA−B0−4714−01 TCGA−A3−3363−01A−01D−0966−08 TCGA−CZ−5463−01A−01D−1501−10 TCGA−CZ−4865−01A−02D−1501−10 TCGA−CZ−4858−01 TCGA−CJ−5677−01A−11D−1534−10 TCGA−BP−4798−01 TCGA−BP−4770−01A−01D−1501−10 TCGA−BP−4176−01A−02D−1366−10 TCGA−B0−4710−01 TCGA−B0−4703−01

FOXM1 Transcription Factor Network FDR = 0.29%, FDR nod = 1.2% DNA Damage/Telomere Stress Induced Senescence FDR = 0.14%, FDR nod = 1.9%

ATM

BRCA2 TP53

CENPF

TCGA−BP−4770−01A−01D−1501−10 TCGA−CJ−4912−01A−01D−1429−08 TCGA−CJ−4874−01A−01D−1373−10 TCGA−BP−4759−01 TCGA−BP−4343−01A−02D−1366−10 TCGA−B0−4710−01 TCGA−BP−4165−01 TCGA−CZ−4858−01 TCGA−CJ−4639−01A−02D−1386−10 TCGA−CZ−5457−01 TCGA−CJ−4637−01A−02D−1386−10 TCGA−CZ−4865−01A−02D−1501−10 TCGA−A3−3382−01A−01D−0966−08 TCGA−B0−4691−01A−01D−1361−10 TCGA−AK−3461−01A−02D−1361−10 TCGA−A3−3367−01A−02D−1421−08 TCGA−CW−5591−01A−01D−1534−10 TCGA−B0−5703−01A−11D−1534−10 TCGA−B0−4827−01A−02D−1421−08 TCGA−B0−4707−01 TCGA−CW−6087−01A−11D−1669−08 TCGA−BP−4163−01 TCGA−B0−4833−01 TCGA−BP−4345−01A−01D−1366−10 TCGA−B0−5691−01A−11D−1534−10 TCGA−B0−4694−01A−01D−1361−10 TCGA−BP−4762−01 TCGA−BP−4331−01A−01D−1366−10 TCGA−B8−4621−01 TCGA−B0−5706−01A−11D−1534−10 TCGA−CZ−5451−01A−01D−1501−10 TCGA−BP−5001−01 TCGA−BP−4960−01A−01D−1462−08 TCGA−B8−5159−01A−01D−1421−08 TCGA−B0−5108−01A−01D−1421−08 TCGA−B0−5692−01A−11D−1534−10 TCGA−CZ−5466−01 TCGA−B0−5104−01 TCGA−B0−5088−01A−01D−1462−08 TCGA−A3−3323−01A−01D−0966−08 TCGA−CJ−6030−01A−11D−1669−08 TCGA−CZ−4859−01A−02D−1429−08 TCGA−B8−5158−01A−01D−1421−08 TCGA−B0−5713−01A−11D−1669−08 TCGA−B0−4811−01A−01D−1501−10 TCGA−A3−3378−01A−01D−0966−08 TCGA−CJ−6033−01A−11D−1669−08 TCGA−CJ−5686−01A−11D−1669−08 TCGA−BP−5200−01 TCGA−BP−4329−01A−02D−1366−10 TCGA−BP−4174−01A−02D−1366−10 TCGA−B0−5099−01A−01D−1421−08 TCGA−B0−5080−01A−01D−1501−10 TCGA−CZ−5982−01A−11D−1669−08 TCGA−BP−4801−01A−02D−1421−08 TCGA−B8−4622−01 TCGA−B2−5641−01A−01D−1534−10 TCGA−B0−5077−01A−01D−1462−08 TCGA−A3−3365−01 TCGA−A3−3311−01A−01D−0966−08 TCGA−A3−3308−01A−01D−0966−08

TCGA−CZ−5458−01A−01D−1501−10 TCGA−BP−4352−01A−01D−1366−10 TCGA−A3−3363−01A−01D−0966−08 TCGA−B0−5113−01A−01D−1421−08 TCGA−CW−5588−01A−01D−1534−10 TCGA−B8−4143−01A−01D−1806−10 TCGA−A3−3322−01 TCGA−B0−5119−01A−02D−1421−08 TCGA−A3−3382−01A−01D−0966−08 TCGA−CZ−5453−01A−01D−1501−10 TCGA−A3−3362−01A−02D−1386−10 TCGA−B0−4845−01 TCGA−A3−3372−01A−01D−0966−08 TCGA−CJ−6028−01A−11D−1669−08 TCGA−B0−5713−01A−11D−1669−08 TCGA−EU−5905−01A−11D−1669−08 TCGA−B8−4621−01 TCGA−A3−3317−01A−01D−0966−08 TCGA−CZ−4862−01A−01D−1373−10 TCGA−CJ−4912−01A−01D−1429−08 TCGA−B0−4691−01A−01D−1361−10 TCGA−CJ−4878−01A−01D−1373−10 TCGA−AK−3445−01 TCGA−AK−3434−01A−02D−1361−10 TCGA−A3−3320−01A−01D−0966−08 TCGA−CZ−4857−01A−01D−1373−10 TCGA−CJ−4882−01A−02D−1429−08 TCGA−BP−4983−01A−01D−1462−08 TCGA−B0−5698−01A−11D−1669−08 TCGA−B0−4718−01A−01D−1361−10 TCGA−CZ−4865−01A−02D−1501−10 TCGA−B0−4710−01 TCGA−CZ−5463−01A−01D−1501−10 TCGA−CZ−4858−01 TCGA−CJ−5677−01A−11D−1534−10 TCGA−BP−4798−01 TCGA−BP−4770−01A−01D−1501−10 TCGA−BP−4176−01A−02D−1366−10 TCGA−B0−4703−01 TCGA−CZ−5986−01A−11D−1669−08 TCGA−CZ−5451−01A−01D−1501−10 TCGA−CZ−4861−01A−01D−1373−10 TCGA−CJ−5686−01A−11D−1669−08 TCGA−CJ−4904−01A−02D−1429−08 TCGA−CJ−4639−01A−02D−1386−10 TCGA−BP−5173−01A−01D−1429−08 TCGA−BP−4964−01A−01D−1462−08 TCGA−B8−4622−01 TCGA−B0−5703−01A−11D−1534−10 TCGA−B0−5097−01A−01D−1421−08 TCGA−B0−4690−01

Meiotic Recombination FDR = 0.22%, FDR nod = 1.8%

TCGA−AK−3444−01A−01D−0966−08 TCGA−B8−5164−01 TCGA−CJ−4920−01A−01D−1429−08 TCGA−B0−4693−01A−01D−1361−10 TCGA−B8−4620−01 TCGA−BP−4352−01A−01D−1366−10 TCGA−A3−3363−01A−01D−0966−08 TCGA−B0−5092−01A−01D−1421−08 TCGA−B0−4714−01 TCGA−B0−5113−01A−01D−1421−08 TCGA−B8−4143−01A−01D−1806−10 TCGA−A3−3322−01 TCGA−BP−4343−01A−02D−1366−10 TCGA−B0−5702−01A−11D−1534−10 TCGA−B0−5699−01 TCGA−B0−4845−01 TCGA−A3−3372−01A−01D−0966−08 TCGA−CJ−6033−01A−11D−1669−08 TCGA−AK−3460−01A−02D−1361−10 TCGA−CZ−4865−01A−02D−1501−10 TCGA−A3−3382−01A−01D−0966−08 TCGA−CZ−5988−01A−11D−1669−08 TCGA−CJ−5677−01A−11D−1534−10 TCGA−CJ−4634−01A−02D−1386−10 TCGA−CZ−4862−01A−01D−1373−10 TCGA−CJ−4912−01A−01D−1429−08 TCGA−B0−4691−01A−01D−1361−10 TCGA−EU−5904−01A−11D−1669−08 TCGA−CZ−5465−01A−01D−1806−10 TCGA−CJ−6031−01A−11D−1669−08 TCGA−B0−5102−01A−01D−1421−08 TCGA−CJ−4643−01A−02D−1386−10 TCGA−BP−4998−01A−01D−1462−08 TCGA−BP−4160−01A−02D−1366−10 TCGA−B0−4824−01 TCGA−CZ−4853−01A−01D−1429−08 TCGA−CW−5588−01A−01D−1534−10 TCGA−CJ−4923−01A−01D−1429−08 TCGA−B0−5710−01A−11D−1669−08 TCGA−B0−4819−01A−01D−1361−10 TCGA−AK−3450−01 TCGA−BP−4801−01A−02D−1421−08 TCGA−CZ−5982−01A−11D−1669−08 TCGA−B2−5641−01A−01D−1534−10 TCGA−B0−5077−01A−01D−1462−08 TCGA−A3−3365−01 TCGA−A3−3311−01A−01D−0966−08 TCGA−A3−3308−01A−01D−0966−08 TCGA−B8−4622−01 TCGA−CZ−4861−01A−01D−1373−10 TCGA−CZ−5986−01A−11D−1669−08 TCGA−CZ−5451−01A−01D−1501−10 TCGA−CJ−5686−01A−11D−1669−08 TCGA−CJ−4904−01A−02D−1429−08 TCGA−CJ−4639−01A−02D−1386−10 TCGA−BP−5173−01A−01D−1429−08 TCGA−BP−4964−01A−01D−1462−08 TCGA−B0−5703−01A−11D−1534−10 TCGA−B0−5097−01A−01D−1421−08 TCGA−B0−4690−01


Signaling By PDGF FDR = 0.21%, FDR nod = 0.97% PDGFR Alpha Signaling Pathway FDR = 3%, FDR nod = 2.1%

BRCA2 unknown CG mut

BLM

RAD50 known HCG mut

BRCA1

MMP2 TINF2

NFATC3 NBN

POT1

ONECUT1 CDK2

CDK2 CDKN1A

CHEK2 HIST1H2AJ

AURKB HIST1H2BJ

GSK3A

CCNE1 HIST1H2BM

CDK4 HIST1H2BO

CENPB HIST1H4E

FOXM1 HIST1H4H

MYC CCNE1 H2AFZ

RB1 KAT5

SKP2

NBN wt


COL6A6 PIK3CA

COL4A5 PDGFRA

THBS1 SOS1

COL4A3 JAK1

THBS3

COL6A5

PIK3R1

THBS4

SHC1

COL9A2

PLAT

ELK1

COL9A1

COL6A1

GRB2

COL4A2

PDGFC

RAPGEF1

PDGFRB

SHB

PDGFD

COL4A1

SHF

SPP1

THBS2

SRF

COL4A4

wt COL6A2 JUN

wt

known HCG mut PDGFRA known HCG mut

wt MSH4

known HCG mut MLH3

TEX15 CDK2

PRDM9 CDK4

HIST1H2AJ

HIST1H2BJ

HIST1H2BO HIST1H3H HIST1H3J

HIST1H4E

HIST1H4H

HIST2H3D MLH1

RAD51 RPA2

H2AFZ

HIST1H2BM TOP3A


LAMA4 RAD50

unknown CG mut ATM


wt wt

CDKN2A ACD

EP300 EP400

known HCG mut CCNB2 known HCG mut CCNA1


CREBBP

CENPA

COL6A3

PLG

TCGA−B0−5094−01A−01D−1421−08 TCGA−B8−5550−01 TCGA−BP−4161−01 TCGA−CZ−5451−01A−01D−1501−10 TCGA−CJ−4894−01A−01D−1373−10 TCGA−A3−3372−01A−01D−0966−08 TCGA−B0−4691−01A−01D−1361−10 TCGA−BP−5168−01A−01D−1421−08 TCGA−B0−4718−01A−01D−1361−10 TCGA−CJ−4890−01A−01D−1373−10 TCGA−B8−4622−01 TCGA−CJ−5686−01A−11D−1669−08 TCGA−BP−4349−01 TCGA−AK−3450−01 TCGA−CZ−5465−01A−01D−1806−10 TCGA−BP−4169−01A−02D−1366−10 TCGA−B0−5699−01 TCGA−A3−3357−01A−02D−1421−08 TCGA−CZ−4863−01A−01D−1501−10 TCGA−CJ−5672−01A−11D−1534−10 TCGA−CW−5581−01 TCGA−B0−5075−01 TCGA−B0−4824−01 TCGA−B0−4694−01A−01D−1361−10 TCGA−B0−5701−01A−11D−1534−10 TCGA−CJ−4881−01A−01D−1373−10 TCGA−BP−4998−01A−01D−1462−08 TCGA−B4−5377−01A−01D−1501−10 TCGA−CJ−4868−01A−01D−1373−10 TCGA−B0−5100−01A−01D−1421−08 TCGA−B0−4843−01A−01D−1361−10 TCGA−A3−3326−01A−01D−0966−08 TCGA−DV−5566−01A−01D−1534−10 TCGA−CZ−4865−01A−02D−1501−10 TCGA−BP−4352−01A−01D−1366−10 TCGA−B8−5553−01A−01D−1534−10 TCGA−A3−3378−01A−01D−0966−08 TCGA−CZ−5459−01A−01D−1501−10 TCGA−CZ−5457−01 TCGA−BP−5187−01 TCGA−BP−4977−01A−01D−1462−08 TCGA−B0−5099−01A−01D−1421−08 TCGA−B0−4833−01 TCGA−CW−5585−01A−01D−1534−10 TCGA−CZ−5467−01A−01D−1501−10 TCGA−CZ−5466−01 TCGA−BP−4798−01 TCGA−B0−5121−01A−02D−1421−08 TCGA−AK−3460−01A−02D−1361−10 TCGA−CJ−4638−01A−02D−1386−10 TCGA−BP−5192−01A−01D−1429−08 TCGA−BP−4981−01A−01D−1462−08 TCGA−B0−5709−01A−11D−1534−10 TCGA−B0−5096−01A−01D−1421−08 TCGA−B0−4852−01A−01D−1501−10 TCGA−B0−4707−01 TCGA−CJ−5671−01A−11D−1534−10 TCGA−CJ−4920−01A−01D−1429−08 TCGA−BP−4964−01A−01D−1462−08 TCGA−BP−4342−01 TCGA−B0−5402−01A−01D−1501−10 TCGA−B0−4823−01A−02D−1421−08 TCGA−A3−3349−01A−01D−1251−10 TCGA−A3−3346−01A−01D−0966−08 TCGA−BP−4337−01A−01D−1366−10 TCGA−A3−3367−01A−02D−1421−08 TCGA−CZ−5988−01A−11D−1669−08 TCGA−CZ−5453−01A−01D−1501−10 TCGA−CZ−4857−01A−01D−1373−10 TCGA−CJ−6030−01A−11D−1669−08 TCGA−CJ−4905−01A−02D−1429−08 TCGA−BP−5202−01A−02D−1429−08 TCGA−B0−5119−01A−02D−1421−08 TCGA−B0−5081−01A−01D−1462−08 TCGA−B0−4712−01A−01D−1501−10 TCGA−AK−3455−01A−01D−0966−08

TCGA−BP−4166−01 TCGA−BP−4801−01A−02D−1421−08 TCGA−BP−4973−01A−01D−1462−08 TCGA−B0−4714−01 TCGA−BP−4329−01A−02D−1366−10 TCGA−CJ−4637−01A−02D−1386−10 TCGA−CJ−5680−01A−11D−1534−10 TCGA−B0−5400−01A−01D−1501−10 TCGA−CZ−4857−01A−01D−1373−10 TCGA−A3−3376−01A−02D−1421−08 TCGA−CZ−5470−01A−01D−1501−10 TCGA−BP−5009−01A−01D−1462−08 TCGA−CZ−4859−01A−02D−1429−08 TCGA−BP−4987−01A−01D−1462−08 TCGA−B0−4845−01 TCGA−CJ−4875−01A−01D−1373−10 TCGA−BP−4985−01A−01D−1462−08 TCGA−BP−4967−01A−01D−1462−08 TCGA−B8−4154−01A−01D−1251−10 TCGA−AK−3444−01A−01D−0966−08 TCGA−CZ−5467−01A−01D−1501−10 TCGA−CZ−5466−01 TCGA−CW−5585−01A−01D−1534−10 TCGA−BP−4798−01 TCGA−B0−5121−01A−02D−1421−08 TCGA−AK−3460−01A−02D−1361−10 TCGA−B0−4824−01 TCGA−CJ−6033−01A−11D−1669−08 TCGA−CJ−4886−01A−01D−1373−10 TCGA−CJ−4873−01A−01D−1373−10 TCGA−CJ−4872−01 TCGA−BP−4960−01A−01D−1462−08 TCGA−BP−4352−01A−01D−1366−10 TCGA−BP−4160−01A−02D−1366−10 TCGA−B8−5159−01A−01D−1421−08 TCGA−B0−5713−01A−11D−1669−08 TCGA−B0−4693−01A−01D−1361−10 TCGA−A3−3357−01A−02D−1421−08

PI3K Events In ERBB4 Signaling FDR = 4.8%, FDR nod = 3%

unknown CG mut


TCGA−CJ−4904−01A−02D−1429−08 TCGA−CZ−4857−01A−01D−1373−10 TCGA−A3−3376−01A−02D−1421−08 TCGA−CJ−5677−01A−11D−1534−10 TCGA−CJ−4903−01A−01D−1429−08 TCGA−CJ−4893−01A−01D−1373−10 TCGA−B0−5119−01A−02D−1421−08 TCGA−B0−4817−01A−01D−1361−10 TCGA−AK−3428−01A−02D−1361−10 TCGA−CZ−5465−01A−01D−1806−10 TCGA−CZ−5457−01 TCGA−CW−6093−01A−11D−1669−08 TCGA−CJ−5679−01 TCGA−B0−4713−01A−01D−1361−10 TCGA−AK−3444−01A−01D−0966−08 TCGA−CJ−6033−01A−11D−1669−08

TCGA−CZ−5470−01A−01D−1501−10 TCGA−B8−4148−01A−02D−1386−10 TCGA−CJ−4918−01A−01D−1429−08 TCGA−CJ−4639−01A−02D−1386−10 TCGA−A3−3387−01A−01D−1534−10 TCGA−BP−5192−01A−01D−1429−08 TCGA−CJ−4913−01A−01D−1429−08 TCGA−BP−4761−01A−01D−1366−10 TCGA−BP−4338−01A−01D−1806−10 TCGA−B0−5075−01 TCGA−A3−3373−01A−02D−1421−08 TCGA−CZ−4859−01A−02D−1429−08 TCGA−CJ−6030−01A−11D−1669−08 TCGA−B8−5158−01A−01D−1421−08 TCGA−B0−5713−01A−11D−1669−08 TCGA−B0−4811−01A−01D−1501−10 TCGA−A3−3378−01A−01D−0966−08 TCGA−CZ−4858−01

PTPN11

TCGA−CJ−4886−01A−01D−1373−10

PTPN1

TCGA−CZ−5463−01A−01D−1501−10

IFNAR1

TCGA−CJ−4873−01A−01D−1373−10

IFNA8

TCGA−CZ−4865−01A−02D−1501−10

IFNA5

TCGA−CJ−4872−01

IFNA21

TCGA−CJ−5677−01A−11D−1534−10

IFNA16

TCGA−BP−4960−01A−01D−1462−08

IFNA14


IFNB1

TCGA−BP−4352−01A−01D−1366−10

wt

TCGA−BP−4770−01A−01D−1501−10

IFNA1

TCGA−BP−4160−01A−02D−1366−10

TYK2

TCGA−BP−4176−01A−02D−1366−10

STAT2

TCGA−B8−5159−01A−01D−1421−08

USP18

known HCG mut PTPN6

TCGA−B0−4710−01

unknown CG mut

TCGA−B0−5713−01A−11D−1669−08

TCGA−B0−4703−01

JAK1

TP53 Regulates Transcription Of Genes Involved In G2 Cell Cycle Arrest FDR = 1%, FDR nod = 2.1% TP53 Regulates Transcription Of Additional Cell Cycle Genes Whose Exact Role In The P53 Pathway Remain Uncertain FDR = 0.67%, FDR nod = 0.97%

TCGA−B0−4824−01

TCGA−CJ−4640−01A−02D−1386−10 TCGA−B8−5549−01A−01D−1534−10 TCGA−BP−5176−01A−01D−1429−08 TCGA−BP−5202−01A−02D−1429−08 TCGA−CZ−5461−01A−01D−1501−10 TCGA−BP−5200−01 TCGA−B2−3924−01 TCGA−B0−5703−01A−11D−1534−10 TCGA−CJ−4907−01A−01D−1429−08 TCGA−B2−4098−01 TCGA−BP−4351−01A−01D−1366−10 TCGA−B0−4847−01A−01D−1361−10 TCGA−CZ−5465−01A−01D−1806−10 TCGA−B0−5100−01A−01D−1421−08 TCGA−BP−4998−01A−01D−1462−08 TCGA−B0−4694−01A−01D−1361−10 TCGA−BP−5192−01A−01D−1429−08 TCGA−A3−3387−01A−01D−1534−10 TCGA−CZ−5987−01A−11D−1669−08 TCGA−CW−6090−01A−11D−1669−08 TCGA−B8−4151−01A−01D−1806−10 TCGA−CJ−5684−01A−11D−1534−10 TCGA−CJ−5679−01 TCGA−BP−4960−01A−01D−1462−08 TCGA−B0−4827−01A−02D−1421−08 TCGA−A3−3378−01A−01D−0966−08 TCGA−A3−3320−01A−01D−0966−08 TCGA−CZ−5458−01A−01D−1501−10 TCGA−CZ−5451−01A−01D−1501−10 TCGA−CJ−4638−01A−02D−1386−10 TCGA−BP−5185−01A−01D−1429−08 TCGA−B8−5159−01A−01D−1421−08 TCGA−B0−5099−01A−01D−1421−08 TCGA−B0−4714−01 TCGA−A3−3363−01A−01D−0966−08 TCGA−CZ−5463−01A−01D−1501−10 TCGA−CZ−4865−01A−02D−1501−10 TCGA−CZ−4858−01 TCGA−CJ−5677−01A−11D−1534−10 TCGA−BP−4798−01 TCGA−BP−4770−01A−01D−1501−10 TCGA−BP−4176−01A−02D−1366−10 TCGA−B0−4710−01 TCGA−B0−4703−01

STAT1

TCGA−B0−4693−01A−01D−1361−10 TCGA−A3−3357−01A−02D−1421−08


Regulation Of IFNA Signaling FDR = 1.1%, FDR nod = 2.1%

wt wt CDC25C

known HCG mut known HCG mut TNKS1BP1

unknown CG mut

PIK3CA

known HCG mut

ERBB4

known HCG mut

wt

wt

NRG1

NRG3

PIK3R1

NRG2


unknown CG mut unknown CG mut TP53

CNOT1

TP53

EP300 CNOT11

TFDP2 CENPJ

CNOT2

CDC25C CNOT3

CNOT4

RBL2 CNOT6

RQCD1

BTG2

CNOT8

PCNA

PLK3

RGCC

ZNF385A

TCGA−B0−5106−01A−01D−1421−08

TCGA−B0−5115−01A−01D−1421−08

TCGA−BP−4352−01A−01D−1366−10

TCGA−AK−3431−01A−02D−1361−10


TCGA−BP−5176−01A−01D−1429−08

TCGA−CJ−6028−01A−11D−1669−08

TCGA−CJ−6033−01A−11D−1669−08

TCGA−BP−4787−01A−01D−1373−10

TCGA−B0−4822−01

TCGA−CZ−5460−01A−01D−1501−10


TCGA−BP−4354−01A−02D−1366−10

TCGA−B0−4852−01A−01D−1501−10

TCGA−B0−4844−01A−01D−1361−10

TCGA−BP−4985−01A−01D−1462−08

TCGA−BP−4756−01A−01D−1366−10

TCGA−B0−5097−01A−01D−1421−08

TCGA−CZ−5458−01A−01D−1501−10


TCGA−AK−3434−01A−02D−1361−10

TCGA−CJ−5676−01A−11D−1534−10

TCGA−CJ−5671−01A−11D−1534−10

TCGA−AK−3454−01A−02D−1361−10

TCGA−BP−4987−01A−01D−1462−08

TCGA−CZ−4859−01A−02D−1429−08

TCGA−B0−4845−01

TCGA−BP−4804−01A−02D−1373−10

TCGA−BP−4777−01A−01D−1366−10

TCGA−B0−5399−01

TCGA−AK−3445−01

LUAD

Collagen Degradation FDR = 0.019%, FDR nod = 0.019% Activation Of Matrix Metalloproteinases FDR = 0.11%, FDR nod = 0.93%

TCGA−17−Z001−01A−01W−0746−08 TCGA−17−Z013−01A−01W−0746−08 TCGA−44−2668−01 TCGA−17−Z008−01A−01W−0746−08 TCGA−05−4389−01A−01D−1265−08 TCGA−17−Z028−01A−01W−0746−08 TCGA−17−Z055−01A−01W−0747−08 TCGA−49−4506−01A−01D−1265−08 TCGA−55−5899−01A−11D−1625−08 TCGA−35−3615−01 TCGA−44−6147−01A−11D−1753−08 TCGA−50−5932−01A−11D−1753−08 TCGA−64−1678−01A−01W−0928−08 TCGA−17−Z033−01A−01W−0746−08 TCGA−44−6779−01A−11D−1855−08 TCGA−17−Z020−01A−01W−0746−08 TCGA−35−3621−01A−01D−0969−08 TCGA−17−Z032−01A−01W−0746−08 TCGA−17−Z043−01A−01W−0746−08 TCGA−17−Z010−01A−01W−0746−08 TCGA−05−4420−01A−01D−1265−08 TCGA−49−6744−01A−11D−1855−08 TCGA−49−4487−01A−21D−1855−08 TCGA−05−4250−01A−01D−1105−08 TCGA−73−4666−01A−01D−1265−08 TCGA−50−5939−01A−11D−1625−08 TCGA−49−4505−01A−01D−1265−08 TCGA−44−6778−01A−11D−1855−08 TCGA−05−4397−01A−01D−1265−08 TCGA−17−Z023−01A−01W−0746−08 TCGA−55−6712−01A−11D−1855−08 TCGA−17−Z017−01A−01W−0746−08 TCGA−05−4432−01A−01D−1265−08 TCGA−44−6145−01A−11D−1753−08 TCGA−35−4122−01A−01D−1105−08 TCGA−17−Z036−01A−01W−0746−08 TCGA−17−Z016−01A−01W−0746−08 TCGA−67−3772−01A−01W−0928−08 TCGA−75−5126−01A−01D−1753−08 TCGA−17−Z051−01A−01W−0747−08 TCGA−49−4510−01A−01D−1265−08 TCGA−44−3398−01A−01D−1105−08 TCGA−44−2665−01 TCGA−05−5715−01A−01D−1625−08 TCGA−05−4382−01A−01D−1265−08 TCGA−67−3771−01 TCGA−50−5049−01A−01D−1625−08 TCGA−50−6590−01A−12D−1855−08 TCGA−05−4398−01A−01D−1265−08 TCGA−44−6774−01A−21D−1855−08 TCGA−44−4112−01 TCGA−44−3919−01 TCGA−17−Z062−01A−01W−0747−08 TCGA−73−4668−01A−01D−1265−08 TCGA−49−4486−01A−01D−1265−08 TCGA−17−Z053−01A−01W−0747−08 TCGA−17−Z044−01A−01W−0746−08 TCGA−17−Z045−01A−01W−0746−08 TCGA−44−2656−01 TCGA−44−3918−01A−01D−1105−08 TCGA−64−5775−01A−01D−1625−08 TCGA−38−4631−01A−01D−1753−08 TCGA−05−5423−01A−01D−1625−08 TCGA−75−5122−01A−01D−1753−08 TCGA−55−1595−01A−01D−0969−08 TCGA−55−1592−01 TCGA−50−6592−01A−11D−1753−08 TCGA−38−4626−01A−01D−1553−08 TCGA−35−4123−01A−01D−1105−08 TCGA−17−Z057−01A−01W−0747−08 TCGA−17−Z012−01A−01W−0746−08 TCGA−05−4424−01A−22D−1855−08 TCGA−05−4410−01A−21D−1855−08 TCGA−80−5611−01A−01D−1625−08 TCGA−49−6767−01A−11D−1855−08 TCGA−05−5428−01A−01D−1625−08 TCGA−05−4417−01A−22D−1855−08 TCGA−91−6836−01A−21D−1855−08 TCGA−67−3773−01 TCGA−50−5933−01A−11D−1753−08 TCGA−50−5072−01A−21D−1855−08 TCGA−17−Z022−01A−01W−0746−08 TCGA−17−Z003−01A−01W−0746−08 TCGA−05−4249−01A−01D−1105−08 TCGA−73−4670−01A−01D−1265−08 TCGA−64−5779−01A−01D−1625−08 TCGA−64−1676−01 TCGA−44−6144−01A−11D−1753−08 TCGA−35−5375−01A−01D−1625−08 TCGA−05−4405−01A−21D−1855−08 TCGA−49−6743−01A−11D−1855−08 TCGA−64−5781−01A−01D−1625−08 TCGA−50−5931−01A−11D−1753−08 TCGA−38−4625−01A−01D−1553−08 TCGA−17−Z014−01A−01W−0746−08 TCGA−05−4390−01A−02D−1753−08 TCGA−75−6211−01A−11D−1753−08 TCGA−64−5815−01A−01D−1625−08 TCGA−64−5778−01A−01D−1625−08 TCGA−64−1677−01A−01W−0928−08 TCGA−50−6594−01A−11D−1753−08 TCGA−17−Z056−01A−01W−0747−08 TCGA−17−Z042−01A−01W−0746−08 TCGA−17−Z030−01A−01W−0746−08 TCGA−17−Z026−01A−01W−0746−08 TCGA−17−Z015−01A−01W−0746−08 TCGA−05−4427−01A−21D−1855−08 TCGA−91−6829−01A−21D−1855−08 TCGA−71−6725−01A−11D−1855−08 TCGA−17−Z049−01A−01W−0746−08 TCGA−17−Z040−01A−01W−0746−08 TCGA−17−Z021−01A−01W−0746−08 TCGA−17−Z018−01A−01W−0746−08

TCGA−17−Z001−01A−01W−0746−08 TCGA−50−6592−01A−11D−1753−08 TCGA−17−Z028−01A−01W−0746−08 TCGA−64−5775−01A−01D−1625−08 TCGA−50−5044−01A−21D−1855−08 TCGA−64−1676−01 TCGA−44−3919−01 TCGA−17−Z013−01A−01W−0746−08 TCGA−35−4122−01A−01D−1105−08 TCGA−05−5423−01A−01D−1625−08 TCGA−75−5125−01A−01D−1753−08 TCGA−05−4384−01A−01D−1753−08 TCGA−64−1677−01A−01W−0928−08 TCGA−05−4389−01A−01D−1265−08 TCGA−49−4506−01A−01D−1265−08 TCGA−17−Z023−01A−01W−0746−08 TCGA−05−5420−01A−01D−1625−08 TCGA−50−6594−01A−11D−1753−08 TCGA−05−4415−01A−22D−1855−08 TCGA−17−Z015−01A−01W−0746−08 TCGA−75−5126−01A−01D−1753−08 TCGA−67−4679−01B−01D−1753−08 TCGA−44−2656−01 TCGA−49−6767−01A−11D−1855−08 TCGA−17−Z043−01A−01W−0746−08 TCGA−17−Z010−01A−01W−0746−08 TCGA−05−4420−01A−01D−1265−08 TCGA−44−4112−01 TCGA−64−5778−01A−01D−1625−08 TCGA−55−5899−01A−11D−1625−08 TCGA−50−5072−01A−21D−1855−08 TCGA−50−6595−01A−12D−1855−08 TCGA−49−4487−01A−21D−1855−08 TCGA−64−1678−01A−01W−0928−08 TCGA−50−6590−01A−12D−1855−08 TCGA−05−4397−01A−01D−1265−08 TCGA−67−3773−01 TCGA−17−Z036−01A−01W−0746−08 TCGA−17−Z033−01A−01W−0746−08 TCGA−91−6828−01A−11D−1855−08 TCGA−73−4676−01A−01D−1753−08 TCGA−50−5933−01A−11D−1753−08 TCGA−50−5931−01A−11D−1753−08 TCGA−35−5375−01A−01D−1625−08 TCGA−35−3621−01A−01D−0969−08 TCGA−17−Z062−01A−01W−0747−08 TCGA−05−4244−01A−01D−1105−08 TCGA−05−4382−01A−01D−1265−08 TCGA−80−5611−01A−01D−1625−08 TCGA−73−4666−01A−01D−1265−08 TCGA−50−5939−01A−11D−1625−08 TCGA−49−4505−01A−01D−1265−08 TCGA−44−6778−01A−11D−1855−08 TCGA−44−6145−01A−11D−1753−08 TCGA−05−4390−01A−02D−1753−08 TCGA−05−4398−01A−01D−1265−08 TCGA−50−5049−01A−01D−1625−08 TCGA−44−3918−01A−01D−1105−08 TCGA−17−Z014−01A−01W−0746−08 TCGA−05−4427−01A−21D−1855−08 TCGA−05−4417−01A−22D−1855−08 TCGA−05−4410−01A−21D−1855−08 TCGA−67−3771−01 TCGA−64−5781−01A−01D−1625−08 TCGA−50−5941−01A−11D−1753−08 TCGA−50−5066−01A−01D−1625−08 TCGA−49−6743−01A−11D−1855−08 TCGA−17−Z055−01A−01W−0747−08 TCGA−17−Z045−01A−01W−0746−08 TCGA−05−4432−01A−01D−1265−08 TCGA−73−4677−01A−01D−1265−08 TCGA−55−1595−01A−01D−0969−08 TCGA−44−2668−01 TCGA−17−Z026−01A−01W−0746−08

PIK3CA

TCGA−38−4626−01A−01D−1553−08 24177 TCGA−05−4410−01A−21D−1855−08 TCGA−91−6829−01A−21D−1855−08 TCGA−67−3770−01 TCGA−05−4405−01A−21D−1855−08 TCGA−50−6595−01A−12D−1855−08 TCGA−49−4501−01A−01D−1265−08 TCGA−44−2656−01 TCGA−64−1677−01A−01W−0928−08 TCGA−55−1592−01 TCGA−44−6778−01A−11D−1855−08 TCGA−38−4629−01A−02D−1265−08 TCGA−35−3621−01A−01D−0969−08 TCGA−44−6777−01A−11D−1855−08 TCGA−35−4122−01A−01D−1105−08 TCGA−17−Z043−01A−01W−0746−08 TCGA−67−3771−01 TCGA−44−4112−01 24318 TCGA−67−4679−01B−01D−1753−08 TCGA−17−Z032−01A−01W−0746−08 TCGA−05−4425−01A−01D−1753−08 TCGA−05−4422−01A−01D−1265−08 TCGA−05−4389−01A−01D−1265−08 TCGA−05−4384−01A−01D−1753−08 24333 TCGA−17−Z022−01A−01W−0746−08 TCGA−05−4427−01A−21D−1855−08 TCGA−64−1678−01A−01W−0928−08 TCGA−50−5051−01A−21D−1855−08 TCGA−49−6767−01A−11D−1855−08 TCGA−49−4488−01A−01D−1753−08 TCGA−44−6774−01A−21D−1855−08 TCGA−44−3918−01A−01D−1105−08 TCGA−44−3398−01A−01D−1105−08 TCGA−17−Z033−01A−01W−0746−08 TCGA−17−Z023−01A−01W−0746−08 TCGA−17−Z021−01A−01W−0746−08 TCGA−17−Z015−01A−01W−0746−08 TCGA−17−Z010−01A−01W−0746−08 TCGA−17−Z026−01A−01W−0746−08 TCGA−17−Z056−01A−01W−0747−08 TCGA−17−Z045−01A−01W−0746−08 TCGA−17−Z012−01A−01W−0746−08 TCGA−91−6836−01A−21D−1855−08 TCGA−73−4659−01A−01D−1265−08 TCGA−55−5899−01A−11D−1625−08 TCGA−50−6591−01A−11D−1753−08 TCGA−50−5049−01A−01D−1625−08 TCGA−49−4507−01A−01D−1265−08 TCGA−38−4631−01A−01D−1753−08 TCGA−17−Z037−01A−01W−0746−08 TCGA−17−Z036−01A−01W−0746−08 TCGA−17−Z013−01A−01W−0746−08 TCGA−17−Z011−01A−01W−0746−08 TCGA−17−Z007−01A−01W−0746−08 TCGA−17−Z003−01A−01W−0746−08 TCGA−17−Z001−01A−01W−0746−08 TCGA−05−4402−01A−01D−1265−08 TCGA−05−4397−01A−01D−1265−08 TCGA−05−4382−01A−01D−1265−08 27229 24687 24683 24667 24621 24604 24303 24269 24212 21452

TCGA−55−1594−01 TCGA−73−4670−01A−01D−1265−08 TCGA−17−Z045−01A−01W−0746−08 TCGA−91−6829−01A−21D−1855−08 TCGA−44−6146−01A−11D−1753−08 TCGA−75−6211−01A−11D−1753−08 24177 TCGA−49−4487−01A−21D−1855−08 TCGA−17−Z003−01A−01W−0746−08 TCGA−44−3919−01 TCGA−44−2656−01 TCGA−64−5775−01A−01D−1625−08 27206 TCGA−38−4631−01A−01D−1753−08 TCGA−38−4629−01A−02D−1265−08 TCGA−17−Z012−01A−01W−0746−08 TCGA−71−6725−01A−11D−1855−08 TCGA−44−2662−01 TCGA−35−4122−01A−01D−1105−08 TCGA−49−4507−01A−01D−1265−08 TCGA−05−4418−01A−01D−1265−08 24320 24319 TCGA−64−5781−01A−01D−1625−08 TCGA−49−4505−01A−01D−1265−08 TCGA−38−6178−01A−11D−1753−08 TCGA−17−Z062−01A−01W−0747−08 TCGA−44−6776−01A−11D−1855−08 TCGA−50−5068−01A−01D−1625−08 TCGA−35−5375−01A−01D−1625−08 TCGA−17−Z014−01A−01W−0746−08 TCGA−50−6594−01A−11D−1753−08 TCGA−35−3621−01A−01D−0969−08 TCGA−17−Z058−01A−01W−0747−08 TCGA−17−Z049−01A−01W−0746−08 TCGA−17−Z046−01A−01W−0746−08 TCGA−49−6767−01A−11D−1855−08 TCGA−49−4514−01A−21D−1855−08 TCGA−05−4417−01A−22D−1855−08 24599 24581 TCGA−67−3772−01A−01W−0928−08 TCGA−50−5941−01A−11D−1753−08 TCGA−44−6144−01A−11D−1753−08 TCGA−17−Z055−01A−01W−0747−08 24486 24256 TCGA−05−4397−01A−01D−1265−08 TCGA−50−6592−01A−11D−1753−08 TCGA−50−6590−01A−12D−1855−08 TCGA−50−5044−01A−21D−1855−08 TCGA−44−2668−01 24617 TCGA−64−1677−01A−01W−0928−08 TCGA−44−5645−01A−01D−1625−08 TCGA−44−5643−01A−01D−1625−08 TCGA−05−4249−01A−01D−1105−08 TCGA−64−1676−01 TCGA−91−6836−01A−21D−1855−08 TCGA−64−5815−01A−01D−1625−08 TCGA−17−Z056−01A−01W−0747−08 TCGA−91−6828−01A−11D−1855−08 TCGA−75−5126−01A−01D−1753−08 TCGA−73−4662−01A−01D−1265−08 TCGA−67−6215−01A−11D−1753−08 TCGA−55−1595−01A−01D−0969−08 TCGA−50−6593−01A−11D−1753−08 TCGA−17−Z028−01A−01W−0746−08 TCGA−17−Z016−01A−01W−0746−08 TCGA−05−5428−01A−01D−1625−08 TCGA−05−4405−01A−21D−1855−08 TCGA−67−3771−01 TCGA−49−6743−01A−11D−1855−08 TCGA−05−4382−01A−01D−1265−08 TCGA−55−5899−01A−11D−1625−08 TCGA−38−4625−01A−01D−1553−08 TCGA−05−4424−01A−22D−1855−08 TCGA−05−4420−01A−01D−1265−08 24667 TCGA−50−5049−01A−01D−1625−08 TCGA−44−3918−01A−01D−1105−08 TCGA−17−Z060−01A−01W−0747−08 TCGA−17−Z026−01A−01W−0746−08 TCGA−17−Z022−01A−01W−0746−08 TCGA−05−4427−01A−21D−1855−08 TCGA−05−4410−01A−21D−1855−08 TCGA−05−4398−01A−01D−1265−08 24181 TCGA−73−4677−01A−01D−1265−08 TCGA−73−4668−01A−01D−1265−08 TCGA−73−4658−01A−01D−1753−08 TCGA−50−5072−01A−21D−1855−08 TCGA−44−6777−01A−11D−1855−08 TCGA−17−Z021−01A−01W−0746−08 TCGA−17−Z015−01A−01W−0746−08 27193 24289

wt

IFNA16

IFN Gamma Signaling Pathway(JAK1 JAK2 STAT1) ( IFN Gamma Signaling(JAK1 JAK2 STAT1) ) FDR = 0.88%, FDR nod = 1.8%

JAK1

unknown CG mut


wt known HCG mut TYK2

wt PTPN13

known HCG mut HCK

EPHB4

BLK

EPHB2

YES1

LYN

MMP2 PLG

PRSS1 MMP9 CMA1

FURIN

MMP14

MMP25 MMP3

MMP7

CTRB2 KLK2

KLKB1

MMP11

MMP17

COL18A1 CTSG CTSK

ELANE

MMP10 MMP8

TPSAB1

ITGA2B

APC

ITGB3

AMER1

LCK

CTNNB1

PPP2R5D

PPP2R1A

PPP2R5A

EFNB1

PPP2R5B

EFNB2

PPP2R5E

DNM1

GSK3B

MAP2K4

MAPK8

PPP2CA

NCK2

PPP2CB

PIK3R1

PPP2R1B

SRC

PPP2R5C

JAK2 STAT3

STAT1

STAT1

IFNA10

IFNA2

IFNG

IFNA7

IFNA14

IFNA17

IFNA4

IFNGR2

IFNA6

IFNA21

IFNA5

IFNAR2

IFNGR1

IFNA8

IRF9

wt AXIN1

FGR

known HCG mut

MAP3K7

unknown CG mut

FYN

wt wt CTSV

APC Truncation Mutants Have Impaired AXIN Binding AXIN Missense Mutants Destabilize The Destruction Complex Beta Catenin Phosphorylation Cascade Misspliced GSK3beta Mutants Stabilize Beta Catenin S33 Mutants Of Beta Catenin Aren't Phosphorylated S37 Mutants Of Beta Catenin Aren't Phosphorylated S45 Mutants Of Beta Catenin Aren't Phosphorylated T41 Mutants Of Beta Catenin Aren't Phosphorylated Truncations Of AMER1 Destabilize The Destruction Complex FDR = 1.1%, FDR nod = 3.4% TIAM1


unknown CG mut EPHB1

unknown CG mut COL19A1 COL12A1 COL15A1 COL14A1 COL25A1 COL17A1 COL9A1 MMP2 COL16A1 MMP9 ADAM17 COL13A1 MMP1 ADAM10 COL23A1 COL9A3 ELANE FURIN MMP10 MMP11 MMP14 MMP19 MMP20 MMP7 ADAM9 COL18A1 COL26A1 COL9A2 CTSB CTSD CTSK MMP3 MMP8 PHYKPL MMP16

unknown CG mut

Ephrin B Reverse Signaling FDR = 2.7%, FDR nod = 0.32%

RGS3

JAK1

unknown CG mut

known HCG mut

STAT2

TCGA−44−2655−01

TCGA−50−5931−01A−11D−1753−08

TCGA−17−Z016−01A−01W−0746−08

TCGA−75−5122−01A−01D−1753−08

TCGA−55−1596−01

TCGA−05−4420−01A−01D−1265−08

TCGA−44−6144−01A−11D−1753−08

TCGA−44−4112−01

TCGA−17−Z022−01A−01W−0746−08

TCGA−05−5429−01A−01D−1625−08

TCGA−75−5146−01A−01D−1625−08

TCGA−50−6590−01A−12D−1855−08

TCGA−49−4514−01A−21D−1855−08

TCGA−05−4250−01A−01D−1105−08

27182

24252

24213

21472

21442

TCGA−91−6829−01A−21D−1855−08

TCGA−73−4662−01A−01D−1265−08

TCGA−67−3771−01

TCGA−50−5072−01A−21D−1855−08

TCGA−38−4625−01A−01D−1553−08

TCGA−17−Z049−01A−01W−0746−08

TCGA−17−Z015−01A−01W−0746−08

24177

21468

TCGA−17−Z055−01A−01W−0747−08 TCGA−49−6744−01A−11D−1855−08 TCGA−05−4427−01A−21D−1855−08 TCGA−49−4514−01A−21D−1855−08 TCGA−50−5049−01A−01D−1625−08 TCGA−44−6776−01A−11D−1855−08 TCGA−91−6831−01A−11D−1855−08 TCGA−49−4506−01A−01D−1265−08 TCGA−17−Z046−01A−01W−0746−08 TCGA−38−4632−01A−01D−1753−08 TCGA−50−5933−01A−11D−1753−08 TCGA−17−Z017−01A−01W−0746−08 TCGA−44−6774−01A−21D−1855−08 TCGA−44−2659−01 TCGA−05−4424−01A−22D−1855−08 TCGA−55−1596−01 TCGA−49−6745−01A−11D−1855−08 TCGA−44−2656−01 TCGA−44−6778−01A−11D−1855−08 TCGA−17−Z043−01A−01W−0746−08 TCGA−05−4420−01A−01D−1265−08 TCGA−05−4410−01A−21D−1855−08 TCGA−17−Z052−01A−01W−0747−08 TCGA−17−Z021−01A−01W−0746−08 TCGA−17−Z022−01A−01W−0746−08 TCGA−44−6144−01A−11D−1753−08 TCGA−44−4112−01 TCGA−05−5429−01A−01D−1625−08 TCGA−75−5147−01A−01D−1625−08 TCGA−35−3621−01A−01D−0969−08 TCGA−05−5423−01A−01D−1625−08 27206 24617 TCGA−91−6836−01A−21D−1855−08 TCGA−73−4668−01A−01D−1265−08 TCGA−44−2662−01 TCGA−17−Z012−01A−01W−0746−08 21454 TCGA−05−4397−01A−01D−1265−08 TCGA−91−6835−01A−11D−1855−08 TCGA−64−1678−01A−01W−0928−08 TCGA−49−6742−01A−11D−1855−08 TCGA−17−Z042−01A−01W−0746−08 TCGA−17−Z028−01A−01W−0746−08 TCGA−17−Z000−01A−01W−0746−08 24604 TCGA−67−3771−01 TCGA−38−4625−01A−01D−1553−08 TCGA−91−6829−01A−21D−1855−08 TCGA−73−4662−01A−01D−1265−08 TCGA−50−5072−01A−21D−1855−08 TCGA−17−Z049−01A−01W−0746−08 TCGA−17−Z015−01A−01W−0746−08 24177 21468

Regulation Of IFNA Signaling FDR = 0.0013%, FDR nod = 0.019% IRF3 Mediated Induction Of Type I IFN FDR = 0.02%, FDR nod = 0.074%

TCGA−17−Z056−01A−01W−0747−08 TCGA−49−6744−01A−11D−1855−08 TCGA−44−6776−01A−11D−1855−08 TCGA−05−4427−01A−21D−1855−08 TCGA−49−4514−01A−21D−1855−08 TCGA−38−4632−01A−01D−1753−08 TCGA−17−Z017−01A−01W−0746−08 TCGA−44−6774−01A−21D−1855−08 TCGA−44−2659−01 TCGA−91−6831−01A−11D−1855−08 TCGA−49−4506−01A−01D−1265−08 TCGA−50−5933−01A−11D−1753−08 TCGA−44−5643−01A−01D−1625−08 TCGA−38−4628−01A−01D−1265−08 TCGA−55−1596−01 TCGA−49−6745−01A−11D−1855−08 TCGA−44−2656−01 TCGA−44−6778−01A−11D−1855−08 TCGA−17−Z043−01A−01W−0746−08 TCGA−05−4420−01A−01D−1265−08 TCGA−05−4410−01A−21D−1855−08 TCGA−17−Z052−01A−01W−0747−08 TCGA−17−Z021−01A−01W−0746−08 TCGA−17−Z022−01A−01W−0746−08 TCGA−44−6144−01A−11D−1753−08 TCGA−44−4112−01 TCGA−05−5429−01A−01D−1625−08 TCGA−05−4424−01A−22D−1855−08 TCGA−50−6592−01A−11D−1753−08 TCGA−05−4417−01A−22D−1855−08 TCGA−05−4398−01A−01D−1265−08 TCGA−75−5147−01A−01D−1625−08 TCGA−35−3621−01A−01D−0969−08 TCGA−05−5423−01A−01D−1625−08 27206 24617 TCGA−91−6836−01A−21D−1855−08 TCGA−73−4668−01A−01D−1265−08 TCGA−44−2662−01 TCGA−17−Z012−01A−01W−0746−08 21454 TCGA−17−Z046−01A−01W−0746−08 TCGA−05−4397−01A−01D−1265−08 TCGA−50−5049−01A−01D−1625−08 TCGA−17−Z050−01A−01W−0747−08 TCGA−17−Z014−01A−01W−0746−08 TCGA−17−Z011−01A−01W−0746−08 24637 24468 24320 TCGA−38−4625−01A−01D−1553−08 TCGA−91−6829−01A−21D−1855−08 TCGA−73−4662−01A−01D−1265−08 TCGA−67−3771−01 TCGA−50−5072−01A−21D−1855−08 TCGA−17−Z049−01A−01W−0746−08 TCGA−17−Z015−01A−01W−0746−08 24177 21468

TCGA−17−Z023−01A−01W−0746−08 TCGA−75−5125−01A−01D−1753−08 TCGA−73−4675−01A−01D−1265−08 TCGA−49−6767−01A−11D−1855−08 TCGA−38−4632−01A−01D−1753−08 TCGA−50−5049−01A−01D−1625−08 TCGA−64−5781−01A−01D−1625−08 TCGA−67−3772−01A−01W−0928−08 TCGA−49−4488−01A−01D−1753−08 TCGA−17−Z046−01A−01W−0746−08 TCGA−05−5715−01A−01D−1625−08 TCGA−17−Z026−01A−01W−0746−08 TCGA−50−5045−01A−01D−1625−08 TCGA−44−3398−01A−01D−1105−08 TCGA−17−Z049−01A−01W−0746−08 TCGA−17−Z045−01A−01W−0746−08 TCGA−67−3771−01 TCGA−64−5778−01A−01D−1625−08 TCGA−44−3918−01A−01D−1105−08 TCGA−44−2668−01 TCGA−17−Z003−01A−01W−0746−08 TCGA−05−4405−01A−21D−1855−08 TCGA−73−4666−01A−01D−1265−08 TCGA−17−Z022−01A−01W−0746−08 TCGA−64−1676−01 TCGA−55−1595−01A−01D−0969−08 TCGA−50−5944−01A−11D−1753−08 TCGA−50−5051−01A−21D−1855−08 TCGA−49−4514−01A−21D−1855−08 TCGA−49−4494−01A−01D−1265−08 TCGA−44−3919−01 TCGA−44−2656−01 TCGA−17−Z042−01A−01W−0746−08 TCGA−05−4424−01A−22D−1855−08 TCGA−05−4410−01A−21D−1855−08 TCGA−64−1678−01A−01W−0928−08 TCGA−91−6829−01A−21D−1855−08 TCGA−17−Z055−01A−01W−0747−08 TCGA−05−4382−01A−01D−1265−08 TCGA−75−5126−01A−01D−1753−08 TCGA−73−4677−01A−01D−1265−08 TCGA−73−4659−01A−01D−1265−08 TCGA−73−4658−01A−01D−1753−08 TCGA−64−5779−01A−01D−1625−08 TCGA−49−6742−01A−11D−1855−08 TCGA−44−4112−01 TCGA−44−2661−01A−01D−1105−08 TCGA−38−6178−01A−11D−1753−08 TCGA−17−Z056−01A−01W−0747−08 TCGA−17−Z028−01A−01W−0746−08 TCGA−17−Z021−01A−01W−0746−08 TCGA−17−Z004−01A−01W−0746−08 TCGA−05−5428−01A−01D−1625−08 TCGA−05−4397−01A−01D−1265−08 TCGA−05−4250−01A−01D−1105−08 24617 24581 24486 24256 24238 24177 21472

Packaging Of Telomere Ends FDR = 0.07%, FDR nod = 0.2% DNA Damage/Telomere Stress Induced Senescence FDR = 2e−12%, FDR nod = 0.0053%

TCGA−17−Z058−01A−01W−0747−08 TCGA−50−5932−01A−11D−1753−08 TCGA−17−Z053−01A−01W−0747−08 TCGA−17−Z033−01A−01W−0746−08 TCGA−17−Z022−01A−01W−0746−08 TCGA−05−4424−01A−22D−1855−08 TCGA−50−6590−01A−12D−1855−08 TCGA−05−4395−01A−01D−1265−08 TCGA−17−Z028−01A−01W−0746−08 TCGA−05−4397−01A−01D−1265−08 TCGA−91−6829−01A−21D−1855−08 TCGA−55−1596−01 TCGA−50−6591−01A−11D−1753−08 TCGA−05−4384−01A−01D−1753−08 TCGA−17−Z049−01A−01W−0746−08 TCGA−73−4658−01A−01D−1753−08 TCGA−75−5126−01A−01D−1753−08 TCGA−64−5778−01A−01D−1625−08 TCGA−55−6642−01A−11D−1855−08 TCGA−44−2655−01 TCGA−50−5066−01A−01D−1625−08 TCGA−38−4625−01A−01D−1553−08 TCGA−35−3621−01A−01D−0969−08 TCGA−73−4668−01A−01D−1265−08 TCGA−49−6767−01A−11D−1855−08 TCGA−44−6777−01A−11D−1855−08 TCGA−05−4410−01A−21D−1855−08 TCGA−64−5781−01A−01D−1625−08 TCGA−17−Z045−01A−01W−0746−08 TCGA−91−6836−01A−21D−1855−08 TCGA−55−1592−01 TCGA−05−5715−01A−01D−1625−08 TCGA−73−4677−01A−01D−1265−08 TCGA−73−4666−01A−01D−1265−08 TCGA−50−5072−01A−21D−1855−08 TCGA−49−4487−01A−21D−1855−08 TCGA−17−Z012−01A−01W−0746−08 TCGA−67−3771−01 TCGA−05−4382−01A−01D−1265−08 TCGA−64−1678−01A−01W−0928−08 TCGA−17−Z015−01A−01W−0746−08 TCGA−44−6774−01A−21D−1855−08 TCGA−44−6145−01A−11D−1753−08 TCGA−44−2668−01 TCGA−38−4629−01A−02D−1265−08 TCGA−17−Z032−01A−01W−0746−08 TCGA−17−Z021−01A−01W−0746−08 TCGA−17−Z000−01A−01W−0746−08

TCGA−17−Z058−01A−01W−0747−08 TCGA−44−3398−01A−01D−1105−08 TCGA−50−5932−01A−11D−1753−08 TCGA−73−4658−01A−01D−1753−08 TCGA−05−5715−01A−01D−1625−08 TCGA−75−5126−01A−01D−1753−08 TCGA−17−Z033−01A−01W−0746−08 TCGA−44−2655−01 TCGA−17−Z032−01A−01W−0746−08 TCGA−17−Z000−01A−01W−0746−08 TCGA−50−5072−01A−21D−1855−08 TCGA−73−4677−01A−01D−1265−08 TCGA−05−5420−01A−01D−1625−08 27235 TCGA−73−4668−01A−01D−1265−08 TCGA−64−5781−01A−01D−1625−08 TCGA−49−4488−01A−01D−1753−08 TCGA−64−5774−01A−01D−1625−08 TCGA−55−6642−01A−11D−1855−08 TCGA−05−4244−01A−01D−1105−08 TCGA−73−4659−01A−01D−1265−08 TCGA−67−6215−01A−11D−1753−08 TCGA−55−1595−01A−01D−0969−08 TCGA−49−4510−01A−01D−1265−08 TCGA−49−4507−01A−01D−1265−08 TCGA−49−4486−01A−01D−1265−08 TCGA−17−Z016−01A−01W−0746−08 TCGA−17−Z014−01A−01W−0746−08 TCGA−05−4417−01A−22D−1855−08 TCGA−05−4390−01A−02D−1753−08 27207 27180 24694 24687 24680 24662 24605 24293 24278 24276 21462 21451 TCGA−05−4410−01A−21D−1855−08 TCGA−05−4382−01A−01D−1265−08 TCGA−91−6836−01A−21D−1855−08 TCGA−67−3771−01 TCGA−64−1678−01A−01W−0928−08 TCGA−50−6590−01A−12D−1855−08 TCGA−35−3621−01A−01D−0969−08 TCGA−17−Z049−01A−01W−0746−08 TCGA−17−Z045−01A−01W−0746−08 TCGA−05−4427−01A−21D−1855−08 TCGA−64−5775−01A−01D−1625−08 TCGA−49−6767−01A−11D−1855−08 TCGA−17−Z026−01A−01W−0746−08 TCGA−17−Z022−01A−01W−0746−08 TCGA−17−Z021−01A−01W−0746−08 TCGA−17−Z015−01A−01W−0746−08 TCGA−91−6829−01A−21D−1855−08 TCGA−75−5125−01A−01D−1753−08 TCGA−73−4666−01A−01D−1265−08 TCGA−67−3770−01 TCGA−64−5778−01A−01D−1625−08 TCGA−55−1596−01 TCGA−55−1592−01 TCGA−50−6593−01A−11D−1753−08 TCGA−50−6591−01A−11D−1753−08 TCGA−50−5066−01A−01D−1625−08 TCGA−50−5049−01A−01D−1625−08 TCGA−50−5045−01A−01D−1625−08 TCGA−49−4487−01A−21D−1855−08 TCGA−44−6778−01A−11D−1855−08 TCGA−44−6777−01A−11D−1855−08 TCGA−44−6774−01A−21D−1855−08 TCGA−44−6145−01A−11D−1753−08 TCGA−44−2668−01 TCGA−44−2659−01 TCGA−38−4630−01A−01D−1265−08 TCGA−38−4629−01A−02D−1265−08 TCGA−38−4625−01A−01D−1553−08 TCGA−17−Z062−01A−01W−0747−08 TCGA−17−Z056−01A−01W−0747−08 TCGA−17−Z055−01A−01W−0747−08 TCGA−17−Z053−01A−01W−0747−08 TCGA−17−Z043−01A−01W−0746−08 TCGA−17−Z028−01A−01W−0746−08 TCGA−17−Z017−01A−01W−0746−08 TCGA−17−Z012−01A−01W−0746−08 TCGA−05−4426−01A−01D−1265−08 TCGA−05−4424−01A−22D−1855−08 TCGA−05−4420−01A−01D−1265−08 TCGA−05−4397−01A−01D−1265−08 TCGA−05−4395−01A−01D−1265−08 TCGA−05−4384−01A−01D−1753−08 24621 TCGA−91−6831−01A−11D−1855−08 TCGA−75−6211−01A−11D−1753−08 TCGA−75−6207−01A−11D−1753−08 TCGA−75−5147−01A−01D−1625−08 TCGA−75−5146−01A−01D−1625−08 TCGA−73−4676−01A−01D−1753−08 TCGA−73−4670−01A−01D−1265−08 TCGA−64−1677−01A−01W−0928−08 TCGA−64−1676−01 TCGA−55−6712−01A−11D−1855−08 TCGA−55−5899−01A−11D−1625−08 TCGA−55−1594−01 TCGA−50−6595−01A−12D−1855−08 TCGA−50−6594−01A−11D−1753−08 TCGA−50−6592−01A−11D−1753−08 TCGA−50−5946−01A−11D−1753−08 TCGA−50−5944−01A−11D−1753−08 TCGA−50−5941−01A−11D−1753−08 TCGA−50−5939−01A−11D−1625−08 TCGA−50−5933−01A−11D−1753−08 TCGA−50−5931−01A−11D−1753−08 TCGA−50−5068−01A−01D−1625−08 TCGA−49−4514−01A−21D−1855−08 TCGA−49−4505−01A−01D−1265−08 TCGA−49−4490−01A−21D−1855−08 TCGA−44−6779−01A−11D−1855−08 TCGA−44−6775−01A−11D−1855−08 TCGA−44−6147−01A−11D−1753−08 TCGA−44−6144−01A−11D−1753−08 TCGA−44−5645−01A−01D−1625−08 TCGA−44−5643−01A−01D−1625−08 TCGA−44−3918−01A−01D−1105−08 TCGA−44−3396−01A−01D−1265−08 TCGA−44−2666−01 TCGA−44−2662−01 TCGA−44−2656−01 TCGA−38−6178−01A−11D−1753−08 TCGA−38−4632−01A−01D−1753−08 TCGA−35−5375−01A−01D−1625−08 TCGA−35−4123−01A−01D−1105−08 TCGA−35−4122−01A−01D−1105−08 TCGA−17−Z061−01A−01W−0747−08 TCGA−17−Z057−01A−01W−0747−08 TCGA−17−Z052−01A−01W−0747−08 TCGA−17−Z047−01A−01W−0747−08 TCGA−17−Z046−01A−01W−0746−08 TCGA−17−Z044−01A−01W−0746−08 TCGA−17−Z042−01A−01W−0746−08 TCGA−17−Z037−01A−01W−0746−08 TCGA−17−Z035−01A−01W−0746−08 TCGA−17−Z030−01A−01W−0746−08 TCGA−17−Z027−01A−01W−0746−08 TCGA−17−Z023−01A−01W−0746−08 TCGA−17−Z020−01A−01W−0746−08 TCGA−17−Z007−01A−01W−0746−08 TCGA−17−Z005−01A−01W−0746−08 TCGA−17−Z003−01A−01W−0746−08 TCGA−17−Z001−01A−01W−0746−08 TCGA−05−5428−01A−01D−1625−08 TCGA−05−5423−01A−01D−1625−08 TCGA−05−4433−01A−22D−1855−08 TCGA−05−4432−01A−01D−1265−08 TCGA−05−4430−01A−02D−1265−08 TCGA−05−4405−01A−21D−1855−08 TCGA−05−4402−01A−01D−1265−08 TCGA−05−4398−01A−01D−1265−08 27224 27210 27206 27201 27197 27193 27188 27185 27182 27178 27175 27173 24693 24689 24682 24681 24678 24669 24667 24665 24663 24656 24653 24633 24625 24623 24617 24607 24600 24599 24598 24597 24486 24468 24331 24320 24319 24317 24312 24302 24301 24295 24292 24291 24289 24279 24270 24269 24256 24252 24250 24245 24239 24238 24205 24177 21472 21468 21454 21452 21442 21438

APC Truncation Mutants Have Impaired AXIN Binding AXIN Missense Mutants Destabilize The Destruction Complex Beta Catenin Phosphorylation Cascade Misspliced GSK3beta Mutants Stabilize Beta Catenin S33 Mutants Of Beta Catenin Aren't Phosphorylated S37 Mutants Of Beta Catenin Aren't Phosphorylated S45 Mutants Of Beta Catenin Aren't Phosphorylated T41 Mutants Of Beta Catenin Aren't Phosphorylated Truncations Of AMER1 Destabilize The Destruction Complex FDR = 1.1%, FDR nod = 3.4%

AMER1

CTNNB1

GSK3B

PPP2CA

PPP2CB

PPP2R1B

STAT2 NLRP4

IFNB1 IFI16

STAT1 MRE11A

IFNA16 XRCC5

PTPN6 DDX41

IFNA4 DTX4

IFNA14 TBK1

IFNA21 TMEM173

IFNA5 XRCC6

IFNAR2 TREX1

USP18 ZBP1

PPP2R5D

PPP2R1A

PPP2R5A

PPP2R5B

wt HIST1H2BI wt

wt IFNA10 wt

known HCG mut TYK2 known HCG mut

known HCG mut HIST1H4I known HCG mut

unknown CGmut mut known HCG wt

TCGA−86−6562−01A−11D−1753−08 TCGA−05−5420−01A−01D−1625−08 TCGA−17−Z050−01A−01W−0747−08 TCGA−38−4626−01A−01D−1553−08 TCGA−55−6543−01A−11D−1753−08 TCGA−49−4488−01A−01D−1753−08 TCGA−17−Z025−01A−01W−0746−08 TCGA−49−4494−01A−01D−1265−08 TCGA−17−Z033−01A−01W−0746−08 TCGA−17−Z060−01A−01W−0747−08 24318 TCGA−17−Z032−01A−01W−0746−08 TCGA−73−4658−01A−01D−1753−08 TCGA−75−5122−01A−01D−1753−08 TCGA−49−6745−01A−11D−1855−08 TCGA−05−4249−01A−01D−1105−08 TCGA−44−6776−01A−11D−1855−08 TCGA−05−5715−01A−01D−1625−08 TCGA−05−4434−01A−01D−1265−08 TCGA−17−Z058−01A−01W−0747−08 TCGA−17−Z008−01A−01W−0746−08 TCGA−67−6217−01A−11D−1753−08 TCGA−50−5051−01A−21D−1855−08 TCGA−05−4418−01A−01D−1265−08 TCGA−50−5072−01A−21D−1855−08 TCGA−38−4628−01A−01D−1265−08 TCGA−38−4631−01A−01D−1753−08 TCGA−49−4506−01A−01D−1265−08 TCGA−71−6725−01A−11D−1855−08 TCGA−17−Z011−01A−01W−0746−08 TCGA−73−4668−01A−01D−1265−08 TCGA−50−5044−01A−21D−1855−08 TCGA−49−6743−01A−11D−1855−08 TCGA−49−4501−01A−01D−1265−08 TCGA−73−4662−01A−01D−1265−08 TCGA−50−5942−01A−21D−1753−08 TCGA−49−6742−01A−11D−1855−08 TCGA−17−Z040−01A−01W−0746−08 TCGA−64−5781−01A−01D−1625−08 TCGA−49−6744−01A−11D−1855−08 TCGA−17−Z000−01A−01W−0746−08 TCGA−67−3774−01 TCGA−75−6206−01A−11D−1753−08 TCGA−44−3919−01 TCGA−17−Z051−01A−01W−0747−08 TCGA−05−4415−01A−22D−1855−08 TCGA−91−6835−01A−11D−1855−08 TCGA−91−6828−01A−11D−1855−08 TCGA−73−4677−01A−01D−1265−08 TCGA−73−4675−01A−01D−1265−08 TCGA−50−5935−01A−11D−1753−08 TCGA−17−Z041−01A−01W−0746−08 TCGA−44−2657−01A−01D−1105−08 TCGA−05−4250−01A−01D−1105−08 TCGA−44−4112−01 TCGA−35−3615−01 TCGA−17−Z010−01A−01W−0746−08 TCGA−80−5611−01A−01D−1625−08 TCGA−49−4486−01A−01D−1265−08 TCGA−05−4417−01A−22D−1855−08 TCGA−49−4510−01A−01D−1265−08 TCGA−17−Z016−01A−01W−0746−08 TCGA−55−1595−01A−01D−0969−08 TCGA−49−4507−01A−01D−1265−08 TCGA−05−4390−01A−02D−1753−08 TCGA−05−4244−01A−01D−1105−08 24687 24293 24276 21462 TCGA−73−4659−01A−01D−1265−08 TCGA−67−6215−01A−11D−1753−08 TCGA−64−5774−01A−01D−1625−08 TCGA−55−6642−01A−11D−1855−08 TCGA−17−Z014−01A−01W−0746−08 27207 27180 24694 24680 24662 24605 24278 21451 TCGA−05−4427−01A−21D−1855−08 TCGA−91−6836−01A−21D−1855−08 TCGA−67−3771−01 TCGA−17−Z022−01A−01W−0746−08 TCGA−05−4432−01A−01D−1265−08 TCGA−05−4382−01A−01D−1265−08 TCGA−50−6590−01A−12D−1855−08 TCGA−05−4410−01A−21D−1855−08 TCGA−17−Z056−01A−01W−0747−08 TCGA−17−Z049−01A−01W−0746−08 TCGA−17−Z045−01A−01W−0746−08 TCGA−73−4670−01A−01D−1265−08 TCGA−64−1676−01 TCGA−50−5045−01A−01D−1625−08 TCGA−44−3918−01A−01D−1105−08 TCGA−38−4625−01A−01D−1553−08 TCGA−17−Z062−01A−01W−0747−08 TCGA−17−Z026−01A−01W−0746−08 TCGA−05−4420−01A−01D−1265−08 TCGA−05−4397−01A−01D−1265−08 TCGA−05−4395−01A−01D−1265−08 TCGA−91−6831−01A−11D−1855−08 TCGA−91−6829−01A−21D−1855−08 TCGA−75−5125−01A−01D−1753−08 TCGA−73−4666−01A−01D−1265−08 TCGA−64−5775−01A−01D−1625−08 TCGA−50−5933−01A−11D−1753−08 TCGA−50−5049−01A−01D−1625−08 TCGA−49−6767−01A−11D−1855−08 TCGA−44−6775−01A−11D−1855−08 TCGA−38−4632−01A−01D−1753−08 TCGA−35−5375−01A−01D−1625−08 TCGA−35−4123−01A−01D−1105−08 TCGA−35−3621−01A−01D−0969−08 TCGA−17−Z057−01A−01W−0747−08 TCGA−17−Z055−01A−01W−0747−08 TCGA−17−Z046−01A−01W−0746−08 TCGA−05−4398−01A−01D−1265−08 TCGA−64−5778−01A−01D−1625−08 TCGA−64−1678−01A−01W−0928−08 TCGA−55−1596−01 TCGA−55−1592−01 TCGA−50−5944−01A−11D−1753−08 TCGA−50−5941−01A−11D−1753−08 TCGA−49−4505−01A−01D−1265−08 TCGA−49−4487−01A−21D−1855−08 TCGA−44−6778−01A−11D−1855−08 TCGA−44−6777−01A−11D−1855−08 TCGA−44−2668−01 TCGA−44−2656−01 TCGA−35−4122−01A−01D−1105−08 TCGA−17−Z061−01A−01W−0747−08 TCGA−17−Z030−01A−01W−0746−08 TCGA−17−Z028−01A−01W−0746−08 TCGA−17−Z027−01A−01W−0746−08 TCGA−17−Z017−01A−01W−0746−08 TCGA−17−Z015−01A−01W−0746−08 TCGA−17−Z012−01A−01W−0746−08 TCGA−05−5428−01A−01D−1625−08 TCGA−05−4424−01A−22D−1855−08 TCGA−05−4405−01A−21D−1855−08 21472 TCGA−75−5146−01A−01D−1625−08 TCGA−73−4676−01A−01D−1753−08 TCGA−67−3770−01 TCGA−55−6712−01A−11D−1855−08 TCGA−55−1594−01 TCGA−50−6595−01A−12D−1855−08 TCGA−50−6594−01A−11D−1753−08 TCGA−50−6592−01A−11D−1753−08 TCGA−50−5066−01A−01D−1625−08 TCGA−49−4514−01A−21D−1855−08 TCGA−49−4490−01A−21D−1855−08 TCGA−44−6774−01A−21D−1855−08 TCGA−44−6145−01A−11D−1753−08 TCGA−44−6144−01A−11D−1753−08 TCGA−44−5645−01A−01D−1625−08 TCGA−44−5643−01A−01D−1625−08 TCGA−44−3396−01A−01D−1265−08 TCGA−44−2662−01 TCGA−38−6178−01A−11D−1753−08 TCGA−38−4630−01A−01D−1265−08 TCGA−17−Z053−01A−01W−0747−08 TCGA−17−Z044−01A−01W−0746−08 TCGA−17−Z043−01A−01W−0746−08 TCGA−17−Z042−01A−01W−0746−08 TCGA−17−Z023−01A−01W−0746−08 TCGA−17−Z020−01A−01W−0746−08 TCGA−17−Z007−01A−01W−0746−08 TCGA−17−Z001−01A−01W−0746−08 TCGA−05−4426−01A−01D−1265−08 TCGA−05−4384−01A−01D−1753−08 27210 27173 24621 24617 24331 24295 24239 24177 21468 21454 21452 21442 21438 TCGA−75−6211−01A−11D−1753−08 TCGA−75−6207−01A−11D−1753−08 TCGA−75−5147−01A−01D−1625−08 TCGA−64−1677−01A−01W−0928−08 TCGA−55−5899−01A−11D−1625−08 TCGA−50−6593−01A−11D−1753−08 TCGA−50−6591−01A−11D−1753−08 TCGA−50−5946−01A−11D−1753−08 TCGA−50−5939−01A−11D−1625−08 TCGA−50−5931−01A−11D−1753−08 TCGA−50−5068−01A−01D−1625−08 TCGA−44−6779−01A−11D−1855−08 TCGA−44−6147−01A−11D−1753−08 TCGA−44−2666−01 TCGA−44−2659−01 TCGA−38−4629−01A−02D−1265−08 TCGA−17−Z052−01A−01W−0747−08 TCGA−17−Z047−01A−01W−0747−08 TCGA−17−Z037−01A−01W−0746−08 TCGA−17−Z035−01A−01W−0746−08 TCGA−17−Z021−01A−01W−0746−08 TCGA−17−Z005−01A−01W−0746−08 TCGA−17−Z003−01A−01W−0746−08 TCGA−05−5423−01A−01D−1625−08 TCGA−05−4433−01A−22D−1855−08 TCGA−05−4430−01A−02D−1265−08 TCGA−05−4402−01A−01D−1265−08 27224 27206 27201 27197 27193 27188 27185 27182 27178 27175 24693 24689 24682 24681 24678 24669 24667 24665 24663 24656 24653 24633 24625 24623 24607 24600 24599 24598 24597 24486 24468 24320 24319 24317 24312 24302 24301 24292 24291 24289 24279 24270 24269 24256 24252 24250 24245 24238 24205

VCP UBE2M UBA3 TNKS2 TNKS TCEB1 SMURF2 SKP1 SHH RFWD2 RELB RELA PSMF1 PSME2 PSMD8 PSMD7 PSMD6 PSMD4 PSMD3 PSMD2 PSMD14 PSMD13 PSMD12 PSMD11 PSMD10 PSMD1 PSMC6 PSMC4 PSMC2 PSMC1 PSMB6 PSMB5 PSMB4 PSMB11 PSMA7 PSMA6 PSMA4 PSMA3 PRKACA PABPC1 P4HB OS9 ORC6 ORC5 ORC2 ORC1 ODC1 NUMB NQO1 NFKB2 MRC1 MCM7 MCM5 MCM2 KLHL12 IHH HSPB1 HSPA8 HSP90AB1 HSP90AA1 HNRNPD GTSE1 GLI1 FCGR1A FBXO5 ERLEC1 DVL2 DVL1 CUL5 CUL1 CHUK CHEK2 CDT1 CDKN1B CDKN1A CDK4 CDK1 CDC25A CCND1 CCNA2 CCNA1 CCL22 CCL17 AZIN1 AXIN1 UBC SEL1L PSME4 PSME1 PRKACB PLK1 ORC4 ORC3 MCM6 GSK3B GLI2 FKBPL EIF4G1 DHH CUL3 CHEK1 CDC20 CD4 CD207 CCNB2 CCNB1 BTRC AXIN2 MRC2 MCM4 MCM3 ITCH HHAT FZR1 DACT1 HECW1 APOBEC3G RB1 DVL3 GLI3 ATM TP53

PPP2R5C

wt

AXIN1

known HCG mut

PPP2R5E

unknown CG mut

TCGA−38−4626−01A−01D−1553−08 24177 TCGA−05−4410−01A−21D−1855−08 TCGA−91−6829−01A−21D−1855−08 TCGA−67−3770−01 TCGA−05−4405−01A−21D−1855−08 TCGA−50−6595−01A−12D−1855−08 TCGA−49−4501−01A−01D−1265−08 TCGA−44−2656−01 TCGA−64−1677−01A−01W−0928−08 TCGA−55−1592−01 TCGA−44−6778−01A−11D−1855−08 TCGA−38−4629−01A−02D−1265−08 TCGA−35−3621−01A−01D−0969−08 TCGA−44−6777−01A−11D−1855−08 TCGA−35−4122−01A−01D−1105−08 TCGA−17−Z043−01A−01W−0746−08 TCGA−67−3771−01 TCGA−44−4112−01 24318 TCGA−67−4679−01B−01D−1753−08 TCGA−17−Z032−01A−01W−0746−08 TCGA−05−4425−01A−01D−1753−08 TCGA−05−4422−01A−01D−1265−08 TCGA−05−4389−01A−01D−1265−08 TCGA−05−4384−01A−01D−1753−08 24333 TCGA−17−Z022−01A−01W−0746−08 TCGA−05−4427−01A−21D−1855−08 TCGA−64−1678−01A−01W−0928−08 TCGA−50−5051−01A−21D−1855−08 TCGA−49−6767−01A−11D−1855−08 TCGA−49−4488−01A−01D−1753−08 TCGA−44−6774−01A−21D−1855−08 TCGA−44−3918−01A−01D−1105−08 TCGA−44−3398−01A−01D−1105−08 TCGA−17−Z033−01A−01W−0746−08 TCGA−17−Z023−01A−01W−0746−08 TCGA−17−Z021−01A−01W−0746−08 TCGA−17−Z015−01A−01W−0746−08 TCGA−17−Z010−01A−01W−0746−08 TCGA−17−Z026−01A−01W−0746−08 TCGA−17−Z056−01A−01W−0747−08 TCGA−17−Z045−01A−01W−0746−08 TCGA−17−Z012−01A−01W−0746−08 TCGA−91−6836−01A−21D−1855−08 TCGA−73−4659−01A−01D−1265−08 TCGA−55−5899−01A−11D−1625−08 TCGA−50−6591−01A−11D−1753−08 TCGA−50−5049−01A−01D−1625−08 TCGA−49−4507−01A−01D−1265−08 TCGA−38−4631−01A−01D−1753−08 TCGA−17−Z037−01A−01W−0746−08 TCGA−17−Z036−01A−01W−0746−08 TCGA−17−Z013−01A−01W−0746−08 TCGA−17−Z011−01A−01W−0746−08 TCGA−17−Z007−01A−01W−0746−08 TCGA−17−Z003−01A−01W−0746−08 TCGA−17−Z001−01A−01W−0746−08 TCGA−05−4402−01A−01D−1265−08 TCGA−05−4397−01A−01D−1265−08 TCGA−05−4382−01A−01D−1265−08 27229 24687 24683 24667 24621 24604 24303 24269 24212 21452

AUF1 (hnRNP D0) Binds And Destabilizes MRNA Autodegradation Of The E3 Ubiquitin Ligase COP1 CDK Mediated Phosphorylation And Removal Of Cdc6 CDT1 Association With The CDC6:ORC:origin Complex Cross Presentation Of Soluble Exogenous Antigens (endosomes) Dectin 1 Mediated Noncanonical NF KB Signaling Degradation Of AXIN Degradation Of DVL Degradation Of GLI1 By The Proteasome Degradation Of GLI2 By The Proteasome G2/M Checkpoints GLI3 Is Processed To GLI3R By The Proteasome Hedgehog Ligand Biogenesis Hh Mutants That Don't Undergo Autocatalytic Processing Are Degraded By ERAD NIK >noncanonical NF KB Signaling Orc1 Removal From Chromatin Regulation Of Activated PAK 2p34 By Proteasome Mediated Degradation Regulation Of Ornithine Decarboxylase (ODC) SCF Beta TrCP Mediated Degradation Of Emi1 The Role Of GTSE1 In G2/M Progression After G2 Checkpoint Ubiquitin Dependent Degradation Of Cyclin D1 Ubiquitin Mediated Degradation Of Phosphorylated Cdc25A Vif Mediated Degradation Of APOBEC3G Vpu Mediated Degradation Of CD4 FDR = 2e−12%, FDR nod = 0.66%

APC

JAK1 PRKDC

unknown CG mut POT1 unknown CG mut

HIST2H2AC

HIST1H2BC

HIST1H2BH

HIST3H2BB ACD

HIST1H2AC

HIST1H2BJ HIST1H4E

HIST1H4H

HIST2H2BE TINF2

HIST1H2AB HIST1H2BF HIST1H4J H2AFX

HIST1H2AE HIST1H2AJ

HIST1H2BL

HIST1H2BN HIST1H4B

HIST1H4D HIST1H4L TERF1

TP53 ATM EP400 CCNE1 HIST2H2AC POT1 ACD HIST1H2AB HIST1H2AC HIST1H2BC HIST1H2BI HIST1H4J MRE11A CCNA1 CCNA2 CDKN1A CDKN1B H2AFX HIST1H2AE HIST1H2AJ HIST1H2BF HIST1H2BH HIST1H2BJ HIST1H2BL HIST1H2BN HIST1H4B HIST1H4D HIST1H4E HIST1H4H HIST1H4I HIST1H4L HIST2H2BE HIST3H2BB NBN RAD50 TERF1 TINF2


PTPN11

IFNA2

IFNA7

IFNA17

IFNA6

IFNA8

P53 Pathway Feedback Loops 2 FDR = 2e−12%, FDR nod = 2.9e−05% P53 Pathway FDR = 2e−12%, FDR nod = 1%

TCGA−17−Z058−01A−01W−0747−08 27223 27177 21458 TCGA−75−5122−01A−01D−1753−08 TCGA−44−2657−01A−01D−1105−08 21473 TCGA−91−6835−01A−11D−1855−08 TCGA−17−Z051−01A−01W−0747−08 TCGA−49−4506−01A−01D−1265−08 24651 TCGA−80−5611−01A−01D−1625−08 TCGA−73−4668−01A−01D−1265−08 TCGA−49−6743−01A−11D−1855−08 TCGA−50−5044−01A−21D−1855−08 24666 TCGA−17−Z025−01A−01W−0746−08 TCGA−17−Z018−01A−01W−0746−08 24280 TCGA−05−5420−01A−01D−1625−08 27235 TCGA−64−1680−01 TCGA−71−6725−01A−11D−1855−08 24692 TCGA−44−3398−01A−01D−1105−08 TCGA−73−4658−01A−01D−1753−08 24609 24261 21462 TCGA−67−6215−01A−11D−1753−08 TCGA−49−4507−01A−01D−1265−08 TCGA−49−4486−01A−01D−1265−08 24680 TCGA−44−4112−01 TCGA−17−Z032−01A−01W−0746−08 TCGA−05−4389−01A−01D−1265−08 TCGA−05−4425−01A−01D−1753−08 TCGA−05−4422−01A−01D−1265−08 24333 24318 TCGA−05−4417−01A−22D−1855−08 TCGA−64−5774−01A−01D−1625−08 TCGA−73−4677−01A−01D−1265−08 TCGA−55−1595−01A−01D−0969−08 TCGA−44−6776−01A−11D−1855−08 TCGA−17−Z060−01A−01W−0747−08 TCGA−17−Z016−01A−01W−0746−08 27180 24694 24276 TCGA−91−6828−01A−11D−1855−08 TCGA−73−4659−01A−01D−1265−08 TCGA−67−4679−01B−01D−1753−08 TCGA−55−6642−01A−11D−1855−08 TCGA−49−4510−01A−01D−1265−08 TCGA−17−Z014−01A−01W−0746−08 TCGA−17−Z010−01A−01W−0746−08 TCGA−05−4415−01A−22D−1855−08 TCGA−05−4390−01A−02D−1753−08 TCGA−05−4250−01A−01D−1105−08 TCGA−05−4249−01A−01D−1105−08 TCGA−05−4244−01A−01D−1105−08 27213 27207 24687 24662 24605 24293 24278 21451 TCGA−75−6206−01A−11D−1753−08 TCGA−75−5126−01A−01D−1753−08 TCGA−73−4662−01A−01D−1265−08 TCGA−67−3774−01 TCGA−67−3773−01 TCGA−64−5815−01A−01D−1625−08 TCGA−50−5936−01A−11D−1625−08 TCGA−50−5932−01A−11D−1753−08 TCGA−50−5051−01A−21D−1855−08 TCGA−49−6744−01A−11D−1855−08 TCGA−44−6146−01A−11D−1753−08 TCGA−38−4626−01A−01D−1553−08 TCGA−35−3615−01 TCGA−17−Z050−01A−01W−0747−08 TCGA−17−Z036−01A−01W−0746−08 TCGA−17−Z033−01A−01W−0746−08 TCGA−17−Z008−01A−01W−0746−08 TCGA−05−4418−01A−01D−1265−08 TCGA−05−4403−01A−01D−1265−08 27232 27174 24691 24668 24658 24654 24652 24637 24631 24620 24615 24613 24582 24580 24579 24578 24576 24481 24303 24299 24298 24268 24267 24224 24212 21436 24617 TCGA−05−4397−01A−01D−1265−08 TCGA−44−6777−01A−11D−1855−08 TCGA−17−Z026−01A−01W−0746−08 TCGA−17−Z022−01A−01W−0746−08 TCGA−05−4427−01A−21D−1855−08 21454 TCGA−91−6836−01A−21D−1855−08 TCGA−64−1677−01A−01W−0928−08 TCGA−50−6592−01A−11D−1753−08 TCGA−50−6590−01A−12D−1855−08 TCGA−44−6775−01A−11D−1855−08 TCGA−44−2668−01 TCGA−17−Z062−01A−01W−0747−08 TCGA−17−Z056−01A−01W−0747−08 TCGA−17−Z042−01A−01W−0746−08 TCGA−17−Z017−01A−01W−0746−08 TCGA−05−4410−01A−21D−1855−08 TCGA−05−4382−01A−01D−1265−08 21472 21438 TCGA−91−6829−01A−21D−1855−08 TCGA−67−3771−01 TCGA−64−5778−01A−01D−1625−08 TCGA−64−5775−01A−01D−1625−08 TCGA−64−1678−01A−01W−0928−08 TCGA−64−1676−01 TCGA−50−6594−01A−11D−1753−08 TCGA−50−5933−01A−11D−1753−08 TCGA−50−5049−01A−01D−1625−08 TCGA−44−6778−01A−11D−1855−08 TCGA−44−5643−01A−01D−1625−08 TCGA−35−5375−01A−01D−1625−08 TCGA−17−Z046−01A−01W−0746−08 TCGA−17−Z023−01A−01W−0746−08 TCGA−17−Z015−01A−01W−0746−08 TCGA−05−4420−01A−01D−1265−08 TCGA−05−4405−01A−21D−1855−08 27210 24599 24320 24279 24269 24239 21468 21452 21442 TCGA−91−6831−01A−11D−1855−08 TCGA−75−5146−01A−01D−1625−08 TCGA−73−4670−01A−01D−1265−08 TCGA−55−1596−01 TCGA−55−1594−01 TCGA−55−1592−01 TCGA−50−5941−01A−11D−1753−08 TCGA−49−6767−01A−11D−1855−08 TCGA−49−4505−01A−01D−1265−08 TCGA−44−6779−01A−11D−1855−08 TCGA−44−6145−01A−11D−1753−08 TCGA−44−6144−01A−11D−1753−08 TCGA−44−5645−01A−01D−1625−08 TCGA−44−3396−01A−01D−1265−08 TCGA−38−4632−01A−01D−1753−08 TCGA−38−4630−01A−01D−1265−08 TCGA−35−4123−01A−01D−1105−08 TCGA−35−3621−01A−01D−0969−08 TCGA−17−Z061−01A−01W−0747−08 TCGA−17−Z057−01A−01W−0747−08 TCGA−17−Z049−01A−01W−0746−08 TCGA−17−Z045−01A−01W−0746−08 TCGA−17−Z043−01A−01W−0746−08 TCGA−17−Z037−01A−01W−0746−08 TCGA−17−Z028−01A−01W−0746−08 TCGA−17−Z020−01A−01W−0746−08 TCGA−17−Z005−01A−01W−0746−08 TCGA−17−Z003−01A−01W−0746−08 TCGA−05−4433−01A−22D−1855−08 TCGA−05−4430−01A−02D−1265−08 TCGA−05−4426−01A−01D−1265−08 TCGA−05−4424−01A−22D−1855−08 TCGA−05−4402−01A−01D−1265−08 TCGA−05−4398−01A−01D−1265−08 TCGA−05−4395−01A−01D−1265−08 TCGA−05−4384−01A−01D−1753−08 27224 27206 27201 27193 27178 27175 24681 24667 24665 24663 24656 24653 24633 24625 24623 24621 24600 24598 24486 24468 24331 24317 24292 24252 24245 24177 TCGA−75−6211−01A−11D−1753−08 TCGA−75−6207−01A−11D−1753−08 TCGA−75−5147−01A−01D−1625−08 TCGA−75−5125−01A−01D−1753−08 TCGA−73−4676−01A−01D−1753−08 TCGA−73−4666−01A−01D−1265−08 TCGA−67−3770−01 TCGA−55−6712−01A−11D−1855−08 TCGA−55−5899−01A−11D−1625−08 TCGA−50−6595−01A−12D−1855−08 TCGA−50−6593−01A−11D−1753−08 TCGA−50−6591−01A−11D−1753−08 TCGA−50−5946−01A−11D−1753−08 TCGA−50−5944−01A−11D−1753−08 TCGA−50−5939−01A−11D−1625−08 TCGA−50−5931−01A−11D−1753−08 TCGA−50−5068−01A−01D−1625−08 TCGA−50−5066−01A−01D−1625−08 TCGA−50−5045−01A−01D−1625−08 TCGA−49−4514−01A−21D−1855−08 TCGA−49−4490−01A−21D−1855−08 TCGA−49−4487−01A−21D−1855−08 TCGA−44−6774−01A−21D−1855−08 TCGA−44−6147−01A−11D−1753−08 TCGA−44−3918−01A−01D−1105−08 TCGA−44−2666−01 TCGA−44−2662−01 TCGA−44−2659−01 TCGA−44−2656−01 TCGA−38−6178−01A−11D−1753−08 TCGA−38−4629−01A−02D−1265−08 TCGA−38−4625−01A−01D−1553−08 TCGA−35−4122−01A−01D−1105−08 TCGA−17−Z055−01A−01W−0747−08 TCGA−17−Z053−01A−01W−0747−08 TCGA−17−Z052−01A−01W−0747−08 TCGA−17−Z047−01A−01W−0747−08 TCGA−17−Z044−01A−01W−0746−08 TCGA−17−Z035−01A−01W−0746−08 TCGA−17−Z030−01A−01W−0746−08 TCGA−17−Z027−01A−01W−0746−08 TCGA−17−Z021−01A−01W−0746−08 TCGA−17−Z012−01A−01W−0746−08 TCGA−17−Z007−01A−01W−0746−08 TCGA−17−Z001−01A−01W−0746−08 TCGA−05−5428−01A−01D−1625−08 TCGA−05−5423−01A−01D−1625−08 TCGA−05−4432−01A−01D−1265−08 27197 27188 27185 27182 27173 24693 24689 24682 24678 24669 24607 24597 24319 24312 24302 24301 24295 24291 24289 24270 24256 24250 24238 24205

24267 24193 TCGA−17−Z059−01A−01W−0747−08 TCGA−05−4250−01A−01D−1105−08 TCGA−17−Z060−01A−01W−0747−08 TCGA−17−Z010−01A−01W−0746−08 TCGA−64−5774−01A−01D−1625−08 TCGA−05−4244−01A−01D−1105−08 TCGA−73−4659−01A−01D−1265−08 TCGA−67−6215−01A−11D−1753−08 TCGA−55−6642−01A−11D−1855−08 TCGA−55−1595−01A−01D−0969−08 TCGA−49−4510−01A−01D−1265−08 TCGA−49−4507−01A−01D−1265−08 TCGA−49−4486−01A−01D−1265−08 TCGA−17−Z016−01A−01W−0746−08 TCGA−17−Z014−01A−01W−0746−08 TCGA−05−4417−01A−22D−1855−08 TCGA−05−4390−01A−02D−1753−08 27207 27180 24694 24687 24680 24662 24605 24293 24278 24276 21462 21451 TCGA−17−Z023−01A−01W−0746−08 TCGA−91−6836−01A−21D−1855−08 TCGA−91−6829−01A−21D−1855−08 TCGA−67−3770−01 TCGA−64−5775−01A−01D−1625−08 TCGA−64−1677−01A−01W−0928−08 TCGA−50−5939−01A−11D−1625−08 TCGA−44−6779−01A−11D−1855−08 TCGA−44−6775−01A−11D−1855−08 TCGA−44−2668−01 TCGA−17−Z062−01A−01W−0747−08 TCGA−17−Z056−01A−01W−0747−08 TCGA−17−Z045−01A−01W−0746−08 TCGA−17−Z043−01A−01W−0746−08 TCGA−17−Z026−01A−01W−0746−08 TCGA−17−Z022−01A−01W−0746−08 TCGA−17−Z017−01A−01W−0746−08 TCGA−17−Z015−01A−01W−0746−08 TCGA−05−4426−01A−01D−1265−08 TCGA−05−4424−01A−22D−1855−08 TCGA−05−4402−01A−01D−1265−08 TCGA−05−4398−01A−01D−1265−08 TCGA−05−4397−01A−01D−1265−08 TCGA−05−4382−01A−01D−1265−08 27201 24621 24317 21472 TCGA−91−6831−01A−11D−1855−08 TCGA−75−6211−01A−11D−1753−08 TCGA−75−6207−01A−11D−1753−08 TCGA−75−5147−01A−01D−1625−08 TCGA−75−5146−01A−01D−1625−08 TCGA−75−5125−01A−01D−1753−08 TCGA−73−4676−01A−01D−1753−08 TCGA−73−4670−01A−01D−1265−08 TCGA−73−4666−01A−01D−1265−08 TCGA−67−3771−01 TCGA−64−5778−01A−01D−1625−08 TCGA−64−1678−01A−01W−0928−08 TCGA−64−1676−01 TCGA−55−6712−01A−11D−1855−08 TCGA−55−5899−01A−11D−1625−08 TCGA−55−1596−01 TCGA−55−1594−01 TCGA−55−1592−01 TCGA−50−6595−01A−12D−1855−08 TCGA−50−6594−01A−11D−1753−08 TCGA−50−6593−01A−11D−1753−08 TCGA−50−6592−01A−11D−1753−08 TCGA−50−6591−01A−11D−1753−08 TCGA−50−6590−01A−12D−1855−08 TCGA−50−5946−01A−11D−1753−08 TCGA−50−5944−01A−11D−1753−08 TCGA−50−5941−01A−11D−1753−08 TCGA−50−5933−01A−11D−1753−08 TCGA−50−5931−01A−11D−1753−08 TCGA−50−5068−01A−01D−1625−08 TCGA−50−5066−01A−01D−1625−08 TCGA−50−5049−01A−01D−1625−08 TCGA−50−5045−01A−01D−1625−08 TCGA−49−6767−01A−11D−1855−08 TCGA−49−4514−01A−21D−1855−08 TCGA−49−4505−01A−01D−1265−08 TCGA−49−4490−01A−21D−1855−08 TCGA−49−4487−01A−21D−1855−08 TCGA−44−6778−01A−11D−1855−08 TCGA−44−6777−01A−11D−1855−08 TCGA−44−6774−01A−21D−1855−08 TCGA−44−6147−01A−11D−1753−08 TCGA−44−6145−01A−11D−1753−08 TCGA−44−6144−01A−11D−1753−08 TCGA−44−5645−01A−01D−1625−08 TCGA−44−5643−01A−01D−1625−08 TCGA−44−3918−01A−01D−1105−08 TCGA−44−3396−01A−01D−1265−08 TCGA−44−2666−01 TCGA−44−2662−01 TCGA−44−2659−01 TCGA−44−2656−01 TCGA−38−6178−01A−11D−1753−08 TCGA−38−4632−01A−01D−1753−08 TCGA−38−4630−01A−01D−1265−08 TCGA−38−4629−01A−02D−1265−08 TCGA−38−4625−01A−01D−1553−08 TCGA−35−5375−01A−01D−1625−08 TCGA−35−4123−01A−01D−1105−08 TCGA−35−4122−01A−01D−1105−08 TCGA−35−3621−01A−01D−0969−08 TCGA−17−Z061−01A−01W−0747−08 TCGA−17−Z057−01A−01W−0747−08 TCGA−17−Z055−01A−01W−0747−08 TCGA−17−Z053−01A−01W−0747−08 TCGA−17−Z052−01A−01W−0747−08 TCGA−17−Z049−01A−01W−0746−08 TCGA−17−Z047−01A−01W−0747−08 TCGA−17−Z046−01A−01W−0746−08 TCGA−17−Z044−01A−01W−0746−08 TCGA−17−Z042−01A−01W−0746−08 TCGA−17−Z037−01A−01W−0746−08 TCGA−17−Z035−01A−01W−0746−08 TCGA−17−Z030−01A−01W−0746−08 TCGA−17−Z028−01A−01W−0746−08 TCGA−17−Z027−01A−01W−0746−08 TCGA−17−Z021−01A−01W−0746−08 TCGA−17−Z020−01A−01W−0746−08 TCGA−17−Z012−01A−01W−0746−08 TCGA−17−Z007−01A−01W−0746−08 TCGA−17−Z005−01A−01W−0746−08 TCGA−17−Z003−01A−01W−0746−08 TCGA−17−Z001−01A−01W−0746−08 TCGA−05−5428−01A−01D−1625−08 TCGA−05−5423−01A−01D−1625−08 TCGA−05−4433−01A−22D−1855−08 TCGA−05−4432−01A−01D−1265−08 TCGA−05−4430−01A−02D−1265−08 TCGA−05−4427−01A−21D−1855−08 TCGA−05−4420−01A−01D−1265−08 TCGA−05−4410−01A−21D−1855−08 TCGA−05−4405−01A−21D−1855−08 TCGA−05−4395−01A−01D−1265−08 TCGA−05−4384−01A−01D−1753−08 27224 27210 27206 27197 27193 27188 27185 27182 27178 27175 27173 24693 24689 24682 24681 24678 24669 24667 24665 24663 24656 24653 24633 24625 24623 24617 24607 24600 24599 24598 24597 24486 24468 24331 24320 24319 24312 24302 24301 24295 24292 24291 24289 24279 24270 24269 24256 24252 24250 24245 24239 24238 24205 24177 21468 21454 21452 21442 21438

Stabilization Of P53 FDR = 2e−12%, FDR nod = 1.2% Regulation Of TP53 Activity Through Phosphorylation FDR = 2e−12%, FDR nod = 1.1%

TCGA−05−5420−01A−01D−1625−08 24267 24193 TCGA−73−4659−01A−01D−1265−08 TCGA−67−6215−01A−11D−1753−08 TCGA−64−5774−01A−01D−1625−08 TCGA−55−6642−01A−11D−1855−08 TCGA−55−1595−01A−01D−0969−08 TCGA−49−4510−01A−01D−1265−08 TCGA−49−4507−01A−01D−1265−08 TCGA−49−4486−01A−01D−1265−08 TCGA−17−Z016−01A−01W−0746−08 TCGA−17−Z014−01A−01W−0746−08 TCGA−05−4417−01A−22D−1855−08 TCGA−05−4390−01A−02D−1753−08 TCGA−05−4244−01A−01D−1105−08 27207 27180 24694 24687 24680 24662 24605 24293 24278 24276 21462 21451 TCGA−91−6836−01A−21D−1855−08 TCGA−64−5775−01A−01D−1625−08 TCGA−67−3771−01 TCGA−49−6767−01A−11D−1855−08 TCGA−49−4514−01A−21D−1855−08 TCGA−44−6775−01A−11D−1855−08 TCGA−17−Z062−01A−01W−0747−08 TCGA−17−Z056−01A−01W−0747−08 TCGA−17−Z017−01A−01W−0746−08 TCGA−05−4397−01A−01D−1265−08 TCGA−05−4382−01A−01D−1265−08 24621 TCGA−91−6831−01A−11D−1855−08 TCGA−91−6829−01A−21D−1855−08 TCGA−75−6211−01A−11D−1753−08 TCGA−75−6207−01A−11D−1753−08 TCGA−75−5147−01A−01D−1625−08 TCGA−75−5146−01A−01D−1625−08 TCGA−75−5125−01A−01D−1753−08 TCGA−73−4676−01A−01D−1753−08 TCGA−73−4670−01A−01D−1265−08 TCGA−73−4666−01A−01D−1265−08 TCGA−67−3770−01 TCGA−64−5778−01A−01D−1625−08 TCGA−64−1678−01A−01W−0928−08 TCGA−64−1677−01A−01W−0928−08 TCGA−64−1676−01 TCGA−55−6712−01A−11D−1855−08 TCGA−55−5899−01A−11D−1625−08 TCGA−55−1596−01 TCGA−55−1594−01 TCGA−55−1592−01 TCGA−50−6595−01A−12D−1855−08 TCGA−50−6594−01A−11D−1753−08 TCGA−50−6593−01A−11D−1753−08 TCGA−50−6592−01A−11D−1753−08 TCGA−50−6591−01A−11D−1753−08 TCGA−50−6590−01A−12D−1855−08 TCGA−50−5946−01A−11D−1753−08 TCGA−50−5944−01A−11D−1753−08 TCGA−50−5941−01A−11D−1753−08 TCGA−50−5939−01A−11D−1625−08 TCGA−50−5933−01A−11D−1753−08 TCGA−50−5931−01A−11D−1753−08 TCGA−50−5068−01A−01D−1625−08 TCGA−50−5066−01A−01D−1625−08 TCGA−50−5049−01A−01D−1625−08 TCGA−50−5045−01A−01D−1625−08 TCGA−49−4505−01A−01D−1265−08 TCGA−49−4490−01A−21D−1855−08 TCGA−49−4487−01A−21D−1855−08 TCGA−44−6779−01A−11D−1855−08 TCGA−44−6778−01A−11D−1855−08 TCGA−44−6777−01A−11D−1855−08 TCGA−44−6774−01A−21D−1855−08 TCGA−44−6147−01A−11D−1753−08 TCGA−44−6145−01A−11D−1753−08 TCGA−44−6144−01A−11D−1753−08 TCGA−44−5645−01A−01D−1625−08 TCGA−44−5643−01A−01D−1625−08 TCGA−44−3918−01A−01D−1105−08 TCGA−44−3396−01A−01D−1265−08 TCGA−44−2668−01 TCGA−44−2666−01 TCGA−44−2662−01 TCGA−44−2659−01 TCGA−44−2656−01 TCGA−38−6178−01A−11D−1753−08 TCGA−38−4632−01A−01D−1753−08 TCGA−38−4630−01A−01D−1265−08 TCGA−38−4629−01A−02D−1265−08 TCGA−38−4625−01A−01D−1553−08 TCGA−35−5375−01A−01D−1625−08 TCGA−35−4123−01A−01D−1105−08 TCGA−35−4122−01A−01D−1105−08 TCGA−35−3621−01A−01D−0969−08 TCGA−17−Z061−01A−01W−0747−08 TCGA−17−Z057−01A−01W−0747−08 TCGA−17−Z055−01A−01W−0747−08 TCGA−17−Z053−01A−01W−0747−08 TCGA−17−Z052−01A−01W−0747−08 TCGA−17−Z049−01A−01W−0746−08 TCGA−17−Z047−01A−01W−0747−08 TCGA−17−Z046−01A−01W−0746−08 TCGA−17−Z045−01A−01W−0746−08 TCGA−17−Z044−01A−01W−0746−08 TCGA−17−Z043−01A−01W−0746−08 TCGA−17−Z042−01A−01W−0746−08 TCGA−17−Z037−01A−01W−0746−08 TCGA−17−Z035−01A−01W−0746−08 TCGA−17−Z030−01A−01W−0746−08 TCGA−17−Z028−01A−01W−0746−08 TCGA−17−Z027−01A−01W−0746−08 TCGA−17−Z026−01A−01W−0746−08 TCGA−17−Z023−01A−01W−0746−08 TCGA−17−Z022−01A−01W−0746−08 TCGA−17−Z021−01A−01W−0746−08 TCGA−17−Z020−01A−01W−0746−08 TCGA−17−Z015−01A−01W−0746−08 TCGA−17−Z012−01A−01W−0746−08 TCGA−17−Z007−01A−01W−0746−08 TCGA−17−Z005−01A−01W−0746−08 TCGA−17−Z003−01A−01W−0746−08 TCGA−17−Z001−01A−01W−0746−08 TCGA−05−5428−01A−01D−1625−08 TCGA−05−5423−01A−01D−1625−08 TCGA−05−4433−01A−22D−1855−08 TCGA−05−4432−01A−01D−1265−08 TCGA−05−4430−01A−02D−1265−08 TCGA−05−4427−01A−21D−1855−08 TCGA−05−4426−01A−01D−1265−08 TCGA−05−4424−01A−22D−1855−08 TCGA−05−4420−01A−01D−1265−08 TCGA−05−4410−01A−21D−1855−08 TCGA−05−4405−01A−21D−1855−08 TCGA−05−4402−01A−01D−1265−08 TCGA−05−4398−01A−01D−1265−08 TCGA−05−4395−01A−01D−1265−08 TCGA−05−4384−01A−01D−1753−08 27224 27210 27206 27201 27197 27193 27188 27185 27182 27178 27175 27173 24693 24689 24682 24681 24678 24669 24667 24665 24663 24656 24653 24633 24625 24623 24617 24607 24600 24599 24598 24597 24486 24468 24331 24320 24319 24317 24312 24302 24301 24295 24292 24291 24289 24279 24270 24269 24256 24252 24250 24245 24239 24238 24205 24177 21472 21468 21454 21452 21442 21438

TCGA−05−5420−01A−01D−1625−08 TCGA−05−4403−01A−01D−1265−08 TCGA−49−4506−01A−01D−1265−08 TCGA−05−5715−01A−01D−1625−08 TCGA−44−2657−01A−01D−1105−08 TCGA−17−Z013−01A−01W−0746−08 TCGA−64−5815−01A−01D−1625−08 TCGA−73−4662−01A−01D−1265−08 TCGA−49−4488−01A−01D−1753−08 TCGA−75−6206−01A−11D−1753−08 TCGA−44−4112−01 TCGA−38−4626−01A−01D−1553−08 TCGA−05−4425−01A−01D−1753−08 TCGA−50−6597−01A−11D−1855−08 TCGA−80−5611−01A−01D−1625−08 TCGA−17−Z060−01A−01W−0747−08 TCGA−44−3398−01A−01D−1105−08 TCGA−44−2655−01 TCGA−67−3773−01 TCGA−67−3772−01A−01W−0928−08 24267 24193 TCGA−49−4494−01A−01D−1265−08 TCGA−64−5781−01A−01D−1625−08 TCGA−50−5044−01A−21D−1855−08 TCGA−64−5779−01A−01D−1625−08 TCGA−05−4250−01A−01D−1105−08 TCGA−17−Z010−01A−01W−0746−08 TCGA−71−6725−01A−11D−1855−08 TCGA−17−Z033−01A−01W−0746−08 TCGA−17−Z018−01A−01W−0746−08 TCGA−75−5126−01A−01D−1753−08 TCGA−49−6742−01A−11D−1855−08 24298 24181 TCGA−73−4658−01A−01D−1753−08 TCGA−38−4631−01A−01D−1753−08 TCGA−05−4389−01A−01D−1265−08 TCGA−44−2665−01 TCGA−44−2661−01A−01D−1105−08 TCGA−05−4418−01A−01D−1265−08 TCGA−55−1595−01A−01D−0969−08 TCGA−17−Z016−01A−01W−0746−08 TCGA−05−4390−01A−02D−1753−08 TCGA−05−4244−01A−01D−1105−08 TCGA−73−4659−01A−01D−1265−08 TCGA−67−6215−01A−11D−1753−08 TCGA−64−5774−01A−01D−1625−08 TCGA−55−6642−01A−11D−1855−08 TCGA−49−4510−01A−01D−1265−08 TCGA−17−Z014−01A−01W−0746−08 27180 24687 24680 24662 24605 24293 24276 21462 21451 TCGA−05−4417−01A−22D−1855−08 TCGA−05−4415−01A−22D−1855−08 TCGA−50−5072−01A−21D−1855−08 TCGA−49−4507−01A−01D−1265−08 TCGA−49−4486−01A−01D−1265−08 TCGA−44−6776−01A−11D−1855−08 27207 24694 24278 TCGA−73−4677−01A−01D−1265−08 TCGA−67−3774−01 TCGA−50−5932−01A−11D−1753−08 TCGA−35−3615−01 TCGA−05−4422−01A−01D−1265−08 27232 27229 27223 27190 27174 24691 24683 24666 24613 24318 24303 24280 24249 24213 24212 24187 21456 21446 21436 TCGA−17−Z022−01A−01W−0746−08 TCGA−17−Z026−01A−01W−0746−08 TCGA−05−4382−01A−01D−1265−08 TCGA−50−5049−01A−01D−1625−08 TCGA−44−2668−01 TCGA−17−Z046−01A−01W−0746−08 TCGA−05−4410−01A−21D−1855−08 TCGA−91−6836−01A−21D−1855−08 TCGA−55−1592−01 TCGA−05−4424−01A−22D−1855−08 TCGA−64−5775−01A−01D−1625−08 TCGA−55−1596−01 TCGA−50−6594−01A−11D−1753−08 TCGA−50−6590−01A−12D−1855−08 TCGA−49−6767−01A−11D−1855−08 TCGA−44−6777−01A−11D−1855−08 TCGA−44−6775−01A−11D−1855−08 TCGA−44−6774−01A−21D−1855−08 TCGA−44−2656−01 TCGA−35−3621−01A−01D−0969−08 TCGA−17−Z055−01A−01W−0747−08 TCGA−17−Z023−01A−01W−0746−08 TCGA−05−4432−01A−01D−1265−08 TCGA−05−4398−01A−01D−1265−08 TCGA−73−4670−01A−01D−1265−08 TCGA−64−5778−01A−01D−1625−08 TCGA−64−1678−01A−01W−0928−08 TCGA−64−1677−01A−01W−0928−08 TCGA−50−6593−01A−11D−1753−08 TCGA−50−5066−01A−01D−1625−08 TCGA−49−4487−01A−21D−1855−08 TCGA−44−6779−01A−11D−1855−08 TCGA−44−6145−01A−11D−1753−08 TCGA−44−6144−01A−11D−1753−08 TCGA−44−3396−01A−01D−1265−08 TCGA−38−4630−01A−01D−1265−08 TCGA−35−4122−01A−01D−1105−08 TCGA−17−Z062−01A−01W−0747−08 TCGA−17−Z056−01A−01W−0747−08 TCGA−17−Z045−01A−01W−0746−08 TCGA−17−Z042−01A−01W−0746−08 TCGA−17−Z017−01A−01W−0746−08 TCGA−17−Z015−01A−01W−0746−08 TCGA−05−4427−01A−21D−1855−08 TCGA−05−4402−01A−01D−1265−08 27210 27173 TCGA−91−6831−01A−11D−1855−08 TCGA−91−6829−01A−21D−1855−08 TCGA−75−5146−01A−01D−1625−08 TCGA−73−4666−01A−01D−1265−08 TCGA−67−3771−01 TCGA−67−3770−01 TCGA−50−5939−01A−11D−1625−08 TCGA−50−5933−01A−11D−1753−08 TCGA−50−5045−01A−01D−1625−08 TCGA−49−4514−01A−21D−1855−08 TCGA−49−4505−01A−01D−1265−08 TCGA−44−6147−01A−11D−1753−08 TCGA−44−5643−01A−01D−1625−08 TCGA−44−3918−01A−01D−1105−08 TCGA−44−2659−01 TCGA−38−4632−01A−01D−1753−08 TCGA−38−4629−01A−02D−1265−08 TCGA−38−4625−01A−01D−1553−08 TCGA−35−5375−01A−01D−1625−08 TCGA−17−Z057−01A−01W−0747−08 TCGA−17−Z049−01A−01W−0746−08 TCGA−17−Z043−01A−01W−0746−08 TCGA−17−Z030−01A−01W−0746−08 TCGA−17−Z027−01A−01W−0746−08 TCGA−17−Z012−01A−01W−0746−08 TCGA−17−Z003−01A−01W−0746−08 TCGA−05−5428−01A−01D−1625−08 TCGA−05−4426−01A−01D−1265−08 TCGA−05−4397−01A−01D−1265−08 TCGA−05−4395−01A−01D−1265−08 TCGA−05−4384−01A−01D−1753−08 27206 27201 27188 27185 24663 24625 24621 24607 24600 24486 24279 24270 24205 21472 21454 TCGA−75−6211−01A−11D−1753−08 TCGA−75−6207−01A−11D−1753−08 TCGA−75−5147−01A−01D−1625−08 TCGA−75−5125−01A−01D−1753−08 TCGA−73−4676−01A−01D−1753−08 TCGA−64−1676−01 TCGA−55−6712−01A−11D−1855−08 TCGA−55−5899−01A−11D−1625−08 TCGA−55−1594−01 TCGA−50−6595−01A−12D−1855−08 TCGA−50−6592−01A−11D−1753−08 TCGA−50−6591−01A−11D−1753−08 TCGA−50−5946−01A−11D−1753−08 TCGA−50−5944−01A−11D−1753−08 TCGA−50−5941−01A−11D−1753−08 TCGA−50−5931−01A−11D−1753−08 TCGA−50−5068−01A−01D−1625−08 TCGA−49−4490−01A−21D−1855−08 TCGA−44−6778−01A−11D−1855−08 TCGA−44−5645−01A−01D−1625−08 TCGA−44−2666−01 TCGA−44−2662−01 TCGA−38−6178−01A−11D−1753−08 TCGA−35−4123−01A−01D−1105−08 TCGA−17−Z061−01A−01W−0747−08 TCGA−17−Z053−01A−01W−0747−08 TCGA−17−Z052−01A−01W−0747−08 TCGA−17−Z047−01A−01W−0747−08 TCGA−17−Z044−01A−01W−0746−08 TCGA−17−Z037−01A−01W−0746−08 TCGA−17−Z035−01A−01W−0746−08 TCGA−17−Z028−01A−01W−0746−08 TCGA−17−Z021−01A−01W−0746−08 TCGA−17−Z020−01A−01W−0746−08 TCGA−17−Z007−01A−01W−0746−08 TCGA−17−Z005−01A−01W−0746−08 TCGA−17−Z001−01A−01W−0746−08 TCGA−05−5423−01A−01D−1625−08 TCGA−05−4433−01A−22D−1855−08 TCGA−05−4430−01A−02D−1265−08 TCGA−05−4420−01A−01D−1265−08 TCGA−05−4405−01A−21D−1855−08 27224 27197 27193 27182 27178 27175 24693 24689 24682 24681 24678 24669 24667 24665 24656 24653 24633 24623 24617 24599 24598 24597 24468 24331 24320 24319 24317 24312 24302 24301 24295 24292 24291 24289 24269 24256 24252 24250 24245 24239 24238 24177 21468 21452 21442 21438

BARD1 Signaling Events FDR = 2e−12%, FDR nod = 0.031% TP53 Regulates Transcription Of Caspase Activators And Caspases FDR = 2e−12%, FDR nod = 0.14%

TP53

ATR

CREBBP

MDM2

AKT1

EP300

KAT2B

PPP2CA

ATM TP53

XRCC5 ATM

BARD1 NLRC4

FANCL

TP63

FANCD2

EWSR1

FANCA

TP73

MRE11A

FANCE

CASP1

FANCC

FANCG

CASP10

FANCF

RAD50

CASP2

NBN

PCNA

RBBP8

CASP6

RAD51

UBE2D3

PIDD1

TOPBP1

XRCC6

known HCG mut ATR known HCG mut

unknown CG mut TP53 unknown CG mut

wt ATM wt

wt wt

wt BRCA1 wt APAF1


known HCG mut known HCG mut ATM


TP53

MDM2

CHEK2

UBC

TP53 STK11 ATM WRN BARD1 TAF1 BLM ATRIP MDM2 PRKAB1 TAF4 ATR BRCA1 BRIP1 DNA2 EXO1 HIPK2 NUAK1 PLK3 PRKAG2 PRKAG3 RFC5 TAF1L TAF3 TAF6 TOPBP1 AURKA AURKB CCNA1 CCNA2 CDK5 CHEK1 CHEK2 HIPK1 HUS1 MAPK11 MAPK14 MAPKAPK5 MRE11A NBN NOC2L PRKAA1 RAD1 RAD17 RAD50 RAD9A RBBP8 RFC2 RFC3 RHNO1 RPA2 SSRP1 TAF10 TAF2 TAF4B TAF9 TAF9B TOP3A TP53INP1 TPX2 UBC

unknown CG mut TP53 KRAS CTNNB1 ATM PTEN PIK3C2B CCNE1 NRAS PIK3C3 PIK3CA PIK3CB PIK3CG RB1 RBL1 AKT2 HRAS PIK3CD TP63 AKT1 AKT3 ATR CCNA1 CCNA2 CCNG1 CDKN1A MAPK11 MAPK14 MYC PIK3C2A PIK3C2G PIK3R1 PIK3R2 PIK3R3 PIK3R5 PPP2CA PPP2CB TP73 unknown CG mut

PRKDC

CCNE1

BACH1

TCGA−05−4403−01A−01D−1265−08 TCGA−44−3398−01A−01D−1105−08 TCGA−17−Z032−01A−01W−0746−08 TCGA−64−1680−01 TCGA−80−5611−01A−01D−1625−08 TCGA−73−4668−01A−01D−1265−08 TCGA−05−5420−01A−01D−1625−08 27235 24298 24181 TCGA−17−Z060−01A−01W−0747−08 TCGA−17−Z010−01A−01W−0746−08 TCGA−64−5781−01A−01D−1625−08 TCGA−67−3772−01A−01W−0928−08 TCGA−49−4488−01A−01D−1753−08 TCGA−05−5715−01A−01D−1625−08 TCGA−75−5126−01A−01D−1753−08 TCGA−49−6742−01A−11D−1855−08 TCGA−73−4677−01A−01D−1265−08 TCGA−73−4658−01A−01D−1753−08 TCGA−64−5779−01A−01D−1625−08 TCGA−44−4112−01 TCGA−44−2661−01A−01D−1105−08 TCGA−17−Z004−01A−01W−0746−08 TCGA−05−4250−01A−01D−1105−08 24581 TCGA−73−4659−01A−01D−1265−08 TCGA−64−5774−01A−01D−1625−08 TCGA−49−4486−01A−01D−1265−08 TCGA−67−6215−01A−11D−1753−08 TCGA−55−6642−01A−11D−1855−08 TCGA−55−1595−01A−01D−0969−08 TCGA−49−4510−01A−01D−1265−08 TCGA−49−4507−01A−01D−1265−08 TCGA−17−Z016−01A−01W−0746−08 TCGA−17−Z014−01A−01W−0746−08 TCGA−05−4417−01A−22D−1855−08 TCGA−05−4390−01A−02D−1753−08 TCGA−05−4244−01A−01D−1105−08 27207 27180 24694 24687 24680 24662 24605 24293 24278 24276 21462 21451 TCGA−73−4666−01A−01D−1265−08 TCGA−35−3621−01A−01D−0969−08 TCGA−05−4420−01A−01D−1265−08 TCGA−05−4382−01A−01D−1265−08 TCGA−91−6829−01A−21D−1855−08 TCGA−64−5775−01A−01D−1625−08 TCGA−64−1678−01A−01W−0928−08 TCGA−50−5049−01A−01D−1625−08 TCGA−44−3396−01A−01D−1265−08 TCGA−44−2668−01 TCGA−17−Z062−01A−01W−0747−08 TCGA−17−Z056−01A−01W−0747−08 TCGA−17−Z055−01A−01W−0747−08 TCGA−17−Z026−01A−01W−0746−08 TCGA−17−Z022−01A−01W−0746−08 TCGA−05−5428−01A−01D−1625−08 TCGA−05−4427−01A−21D−1855−08 TCGA−05−4424−01A−22D−1855−08 TCGA−05−4398−01A−01D−1265−08 TCGA−91−6836−01A−21D−1855−08 TCGA−75−5125−01A−01D−1753−08 TCGA−64−1677−01A−01W−0928−08 TCGA−50−6594−01A−11D−1753−08 TCGA−50−6593−01A−11D−1753−08 TCGA−50−6590−01A−12D−1855−08 TCGA−50−5066−01A−01D−1625−08 TCGA−50−5045−01A−01D−1625−08 TCGA−44−6779−01A−11D−1855−08 TCGA−44−6777−01A−11D−1855−08 TCGA−44−6774−01A−21D−1855−08 TCGA−44−2666−01 TCGA−44−2659−01 TCGA−44−2656−01 TCGA−38−6178−01A−11D−1753−08 TCGA−35−4122−01A−01D−1105−08 TCGA−17−Z061−01A−01W−0747−08 TCGA−17−Z057−01A−01W−0747−08 TCGA−17−Z049−01A−01W−0746−08 TCGA−17−Z046−01A−01W−0746−08 TCGA−17−Z045−01A−01W−0746−08 TCGA−17−Z043−01A−01W−0746−08 TCGA−17−Z042−01A−01W−0746−08 TCGA−17−Z037−01A−01W−0746−08 TCGA−17−Z030−01A−01W−0746−08 TCGA−17−Z028−01A−01W−0746−08 TCGA−17−Z023−01A−01W−0746−08 TCGA−17−Z021−01A−01W−0746−08 TCGA−17−Z020−01A−01W−0746−08 TCGA−17−Z017−01A−01W−0746−08 TCGA−17−Z015−01A−01W−0746−08 TCGA−05−4410−01A−21D−1855−08 TCGA−05−4402−01A−01D−1265−08 TCGA−05−4397−01A−01D−1265−08 27201 24625 24621 24617 24486 24256 24238 24177 21472 TCGA−91−6831−01A−11D−1855−08 TCGA−75−6211−01A−11D−1753−08 TCGA−75−6207−01A−11D−1753−08 TCGA−75−5147−01A−01D−1625−08 TCGA−75−5146−01A−01D−1625−08 TCGA−73−4676−01A−01D−1753−08 TCGA−73−4670−01A−01D−1265−08 TCGA−67−3771−01 TCGA−67−3770−01 TCGA−64−5778−01A−01D−1625−08 TCGA−64−1676−01 TCGA−55−6712−01A−11D−1855−08 TCGA−55−5899−01A−11D−1625−08 TCGA−55−1596−01 TCGA−55−1594−01 TCGA−55−1592−01 TCGA−50−6595−01A−12D−1855−08 TCGA−50−6592−01A−11D−1753−08 TCGA−50−6591−01A−11D−1753−08 TCGA−50−5946−01A−11D−1753−08 TCGA−50−5944−01A−11D−1753−08 TCGA−50−5941−01A−11D−1753−08 TCGA−50−5939−01A−11D−1625−08 TCGA−50−5933−01A−11D−1753−08 TCGA−50−5931−01A−11D−1753−08 TCGA−50−5068−01A−01D−1625−08 TCGA−49−6767−01A−11D−1855−08 TCGA−49−4514−01A−21D−1855−08 TCGA−49−4505−01A−01D−1265−08 TCGA−49−4490−01A−21D−1855−08 TCGA−49−4487−01A−21D−1855−08 TCGA−44−6778−01A−11D−1855−08 TCGA−44−6775−01A−11D−1855−08 TCGA−44−6147−01A−11D−1753−08 TCGA−44−6145−01A−11D−1753−08 TCGA−44−6144−01A−11D−1753−08 TCGA−44−5645−01A−01D−1625−08 TCGA−44−5643−01A−01D−1625−08 TCGA−44−3918−01A−01D−1105−08 TCGA−44−2662−01 TCGA−38−4632−01A−01D−1753−08 TCGA−38−4630−01A−01D−1265−08 TCGA−38−4629−01A−02D−1265−08 TCGA−38−4625−01A−01D−1553−08 TCGA−35−5375−01A−01D−1625−08 TCGA−35−4123−01A−01D−1105−08 TCGA−17−Z053−01A−01W−0747−08 TCGA−17−Z052−01A−01W−0747−08 TCGA−17−Z047−01A−01W−0747−08 TCGA−17−Z044−01A−01W−0746−08 TCGA−17−Z035−01A−01W−0746−08 TCGA−17−Z027−01A−01W−0746−08 TCGA−17−Z012−01A−01W−0746−08 TCGA−17−Z007−01A−01W−0746−08 TCGA−17−Z005−01A−01W−0746−08 TCGA−17−Z003−01A−01W−0746−08 TCGA−17−Z001−01A−01W−0746−08 TCGA−05−5423−01A−01D−1625−08 TCGA−05−4433−01A−22D−1855−08 TCGA−05−4432−01A−01D−1265−08 TCGA−05−4430−01A−02D−1265−08 TCGA−05−4426−01A−01D−1265−08 TCGA−05−4405−01A−21D−1855−08 TCGA−05−4395−01A−01D−1265−08 TCGA−05−4384−01A−01D−1753−08 27224 27210 27206 27197 27193 27188 27185 27182 27178 27175 27173 24693 24689 24682 24681 24678 24669 24667 24665 24663 24656 24653 24633 24623 24607 24600 24599 24598 24597 24468 24331 24320 24319 24317 24312 24302 24301 24295 24292 24291 24289 24279 24270 24269 24252 24250 24245 24239 24205 21468 21454 21452 21442 21438

TCGA−17−Z050−01A−01W−0747−08 TCGA−64−1680−01 TCGA−17−Z058−01A−01W−0747−08 27223 24666 TCGA−91−6828−01A−11D−1855−08 TCGA−17−Z004−01A−01W−0746−08 TCGA−86−6562−01A−11D−1753−08 TCGA−75−6205−01A−11D−1753−08 TCGA−49−6743−01A−11D−1855−08 TCGA−44−6776−01A−11D−1855−08 TCGA−17−Z033−01A−01W−0746−08 TCGA−17−Z014−01A−01W−0746−08 27180 TCGA−73−4659−01A−01D−1265−08 TCGA−67−6215−01A−11D−1753−08 TCGA−64−5774−01A−01D−1625−08 TCGA−55−6642−01A−11D−1855−08 TCGA−55−1595−01A−01D−0969−08 TCGA−49−4510−01A−01D−1265−08 TCGA−49−4507−01A−01D−1265−08 TCGA−49−4486−01A−01D−1265−08 TCGA−17−Z016−01A−01W−0746−08 TCGA−05−4417−01A−22D−1855−08 TCGA−05−4390−01A−02D−1753−08 TCGA−05−4244−01A−01D−1105−08 27207 24694 24687 24680 24662 24605 24293 24278 24276 21462 21451 TCGA−38−4625−01A−01D−1553−08 TCGA−17−Z026−01A−01W−0746−08 TCGA−05−4427−01A−21D−1855−08 TCGA−05−4382−01A−01D−1265−08 TCGA−91−6836−01A−21D−1855−08 TCGA−73−4666−01A−01D−1265−08 TCGA−67−3771−01 TCGA−64−5775−01A−01D−1625−08 TCGA−50−5045−01A−01D−1625−08 TCGA−44−6777−01A−11D−1855−08 TCGA−44−6775−01A−11D−1855−08 TCGA−44−3918−01A−01D−1105−08 TCGA−38−4632−01A−01D−1753−08 TCGA−17−Z062−01A−01W−0747−08 TCGA−17−Z046−01A−01W−0746−08 TCGA−17−Z045−01A−01W−0746−08 TCGA−17−Z023−01A−01W−0746−08 TCGA−17−Z022−01A−01W−0746−08 TCGA−17−Z017−01A−01W−0746−08 TCGA−05−5423−01A−01D−1625−08 TCGA−05−4432−01A−01D−1265−08 TCGA−05−4424−01A−22D−1855−08 TCGA−05−4420−01A−01D−1265−08 TCGA−05−4410−01A−21D−1855−08 TCGA−05−4397−01A−01D−1265−08 24621 24245 21442 TCGA−91−6831−01A−11D−1855−08 TCGA−91−6829−01A−21D−1855−08 TCGA−75−6211−01A−11D−1753−08 TCGA−75−6207−01A−11D−1753−08 TCGA−75−5147−01A−01D−1625−08 TCGA−75−5146−01A−01D−1625−08 TCGA−75−5125−01A−01D−1753−08 TCGA−73−4676−01A−01D−1753−08 TCGA−73−4670−01A−01D−1265−08 TCGA−67−3770−01 TCGA−64−5778−01A−01D−1625−08 TCGA−64−1678−01A−01W−0928−08 TCGA−64−1677−01A−01W−0928−08 TCGA−64−1676−01 TCGA−55−6712−01A−11D−1855−08 TCGA−55−5899−01A−11D−1625−08 TCGA−55−1596−01 TCGA−55−1594−01 TCGA−55−1592−01 TCGA−50−6595−01A−12D−1855−08 TCGA−50−6594−01A−11D−1753−08 TCGA−50−6593−01A−11D−1753−08 TCGA−50−6592−01A−11D−1753−08 TCGA−50−6591−01A−11D−1753−08 TCGA−50−6590−01A−12D−1855−08 TCGA−50−5946−01A−11D−1753−08 TCGA−50−5944−01A−11D−1753−08 TCGA−50−5941−01A−11D−1753−08 TCGA−50−5939−01A−11D−1625−08 TCGA−50−5933−01A−11D−1753−08 TCGA−50−5931−01A−11D−1753−08 TCGA−50−5068−01A−01D−1625−08 TCGA−50−5066−01A−01D−1625−08 TCGA−50−5049−01A−01D−1625−08 TCGA−49−6767−01A−11D−1855−08 TCGA−49−4514−01A−21D−1855−08 TCGA−49−4505−01A−01D−1265−08 TCGA−49−4490−01A−21D−1855−08 TCGA−49−4487−01A−21D−1855−08 TCGA−44−6779−01A−11D−1855−08 TCGA−44−6778−01A−11D−1855−08 TCGA−44−6774−01A−21D−1855−08 TCGA−44−6147−01A−11D−1753−08 TCGA−44−6145−01A−11D−1753−08 TCGA−44−6144−01A−11D−1753−08 TCGA−44−5645−01A−01D−1625−08 TCGA−44−5643−01A−01D−1625−08 TCGA−44−3396−01A−01D−1265−08 TCGA−44−2668−01 TCGA−44−2666−01 TCGA−44−2662−01 TCGA−44−2659−01 TCGA−44−2656−01 TCGA−38−6178−01A−11D−1753−08 TCGA−38−4630−01A−01D−1265−08 TCGA−38−4629−01A−02D−1265−08 TCGA−35−5375−01A−01D−1625−08 TCGA−35−4123−01A−01D−1105−08 TCGA−35−4122−01A−01D−1105−08 TCGA−35−3621−01A−01D−0969−08 TCGA−17−Z061−01A−01W−0747−08 TCGA−17−Z057−01A−01W−0747−08 TCGA−17−Z056−01A−01W−0747−08 TCGA−17−Z055−01A−01W−0747−08 TCGA−17−Z053−01A−01W−0747−08 TCGA−17−Z052−01A−01W−0747−08 TCGA−17−Z049−01A−01W−0746−08 TCGA−17−Z047−01A−01W−0747−08 TCGA−17−Z044−01A−01W−0746−08 TCGA−17−Z043−01A−01W−0746−08 TCGA−17−Z042−01A−01W−0746−08 TCGA−17−Z037−01A−01W−0746−08 TCGA−17−Z035−01A−01W−0746−08 TCGA−17−Z030−01A−01W−0746−08 TCGA−17−Z028−01A−01W−0746−08 TCGA−17−Z027−01A−01W−0746−08 TCGA−17−Z021−01A−01W−0746−08 TCGA−17−Z020−01A−01W−0746−08 TCGA−17−Z015−01A−01W−0746−08 TCGA−17−Z012−01A−01W−0746−08 TCGA−17−Z007−01A−01W−0746−08 TCGA−17−Z005−01A−01W−0746−08 TCGA−17−Z003−01A−01W−0746−08 TCGA−17−Z001−01A−01W−0746−08 TCGA−05−5428−01A−01D−1625−08 TCGA−05−4433−01A−22D−1855−08 TCGA−05−4430−01A−02D−1265−08 TCGA−05−4426−01A−01D−1265−08 TCGA−05−4405−01A−21D−1855−08 TCGA−05−4402−01A−01D−1265−08 TCGA−05−4398−01A−01D−1265−08 TCGA−05−4395−01A−01D−1265−08 TCGA−05−4384−01A−01D−1753−08 27224 27210 27206 27201 27197 27193 27188 27185 27182 27178 27175 27173 24693 24689 24682 24681 24678 24669 24667 24665 24663 24656 24653 24633 24625 24623 24617 24607 24600 24599 24598 24597 24486 24468 24331 24320 24319 24317 24312 24302 24301 24295 24292 24291 24289 24279 24270 24269 24256 24252 24250 24239 24238 24205 24177 21472 21468 21454 21452 21438

E2F Transcription Factor Network FDR = 9.5e−07%, FDR nod = 1.1% DNA Damage/Telomere Stress Induced Senescence FDR = 2e−12%, FDR nod = 0.0053%

TCGA−38−4632−01A−01D−1753−08 TCGA−44−2656−01 TCGA−50−5066−01A−01D−1625−08 TCGA−55−5899−01A−11D−1625−08 TCGA−17−Z056−01A−01W−0747−08 TCGA−17−Z040−01A−01W−0746−08 24600 TCGA−17−Z037−01A−01W−0746−08 TCGA−44−5643−01A−01D−1625−08 TCGA−44−2659−01 TCGA−50−5939−01A−11D−1625−08 21454 TCGA−38−4630−01A−01D−1265−08 TCGA−17−Z009−01A−01W−0746−08 TCGA−17−Z004−01A−01W−0746−08 TCGA−73−4668−01A−01D−1265−08 24620 TCGA−64−1680−01 TCGA−17−Z058−01A−01W−0747−08 TCGA−50−5941−01A−11D−1753−08 TCGA−17−Z012−01A−01W−0746−08 TCGA−49−4514−01A−21D−1855−08 TCGA−44−4112−01 TCGA−17−Z045−01A−01W−0746−08 TCGA−67−3770−01 TCGA−73−4666−01A−01D−1265−08 TCGA−17−Z036−01A−01W−0746−08 TCGA−44−6778−01A−11D−1855−08 TCGA−17−Z028−01A−01W−0746−08 TCGA−73−4658−01A−01D−1753−08 TCGA−17−Z020−01A−01W−0746−08 TCGA−17−Z022−01A−01W−0746−08 TCGA−05−4395−01A−01D−1265−08 TCGA−05−5420−01A−01D−1625−08 27235 TCGA−05−4403−01A−01D−1265−08 TCGA−05−4398−01A−01D−1265−08 TCGA−50−6594−01A−11D−1753−08 TCGA−44−6777−01A−11D−1855−08 TCGA−71−6725−01A−11D−1855−08 TCGA−17−Z011−01A−01W−0746−08 TCGA−73−4662−01A−01D−1265−08 TCGA−38−4626−01A−01D−1553−08 TCGA−05−5423−01A−01D−1625−08 TCGA−05−4250−01A−01D−1105−08 TCGA−67−4679−01B−01D−1753−08 TCGA−73−4677−01A−01D−1265−08 TCGA−35−3621−01A−01D−0969−08 TCGA−50−5072−01A−21D−1855−08 TCGA−05−4420−01A−01D−1265−08 TCGA−44−3396−01A−01D−1265−08 TCGA−80−5611−01A−01D−1625−08 TCGA−50−6593−01A−11D−1753−08 24625 TCGA−49−6743−01A−11D−1855−08 TCGA−05−4249−01A−01D−1105−08 TCGA−73−4676−01A−01D−1753−08 TCGA−50−5935−01A−11D−1753−08 TCGA−38−4631−01A−01D−1753−08 TCGA−75−5126−01A−01D−1753−08 TCGA−17−Z055−01A−01W−0747−08 TCGA−64−5778−01A−01D−1625−08 TCGA−50−6597−01A−11D−1855−08 TCGA−17−Z018−01A−01W−0746−08 TCGA−05−5428−01A−01D−1625−08 24667 24177 TCGA−50−5932−01A−11D−1753−08 TCGA−17−Z010−01A−01W−0746−08 27193 24693 TCGA−50−5045−01A−01D−1625−08 TCGA−05−4432−01A−01D−1265−08 TCGA−64−1676−01 TCGA−38−4629−01A−02D−1265−08 TCGA−35−4122−01A−01D−1105−08 TCGA−05−5715−01A−01D−1625−08 TCGA−44−2657−01A−01D−1105−08 TCGA−05−4410−01A−21D−1855−08 TCGA−50−6592−01A−11D−1753−08 TCGA−17−Z003−01A−01W−0746−08 27213 24663 21473 TCGA−44−3918−01A−01D−1105−08 TCGA−05−4427−01A−21D−1855−08 TCGA−17−Z059−01A−01W−0747−08 TCGA−55−1592−01 TCGA−50−6590−01A−12D−1855−08 TCGA−44−6144−01A−11D−1753−08 TCGA−17−Z053−01A−01W−0747−08 TCGA−17−Z008−01A−01W−0746−08 TCGA−05−4424−01A−22D−1855−08 TCGA−05−4405−01A−21D−1855−08 TCGA−44−6147−01A−11D−1753−08 TCGA−05−4430−01A−02D−1265−08 TCGA−91−6828−01A−11D−1855−08 TCGA−44−6775−01A−11D−1855−08 TCGA−05−4397−01A−01D−1265−08 TCGA−17−Z051−01A−01W−0747−08 TCGA−17−Z049−01A−01W−0746−08 TCGA−17−Z042−01A−01W−0746−08 TCGA−05−4415−01A−22D−1855−08 TCGA−91−6835−01A−11D−1855−08 TCGA−91−6829−01A−21D−1855−08 TCGA−35−5375−01A−01D−1625−08 TCGA−17−Z061−01A−01W−0747−08 27210 24331 24239 21438 TCGA−17−Z026−01A−01W−0746−08 TCGA−67−3771−01 TCGA−17−Z046−01A−01W−0746−08 TCGA−17−Z023−01A−01W−0746−08 TCGA−05−4426−01A−01D−1265−08 TCGA−38−4625−01A−01D−1553−08 TCGA−17−Z057−01A−01W−0747−08 24320 21472 TCGA−55−1594−01 TCGA−50−6595−01A−12D−1855−08 TCGA−49−4505−01A−01D−1265−08 TCGA−44−5645−01A−01D−1625−08 TCGA−17−Z030−01A−01W−0746−08 TCGA−05−4433−01A−22D−1855−08 27186 24653 24633 24607 24597 24251 21468 TCGA−64−5774−01A−01D−1625−08 TCGA−05−4382−01A−01D−1265−08 TCGA−05−4244−01A−01D−1105−08 TCGA−91−6836−01A−21D−1855−08 TCGA−17−Z062−01A−01W−0747−08 TCGA−17−Z014−01A−01W−0746−08 TCGA−05−4390−01A−02D−1753−08 TCGA−73−4659−01A−01D−1265−08 TCGA−55−6642−01A−11D−1855−08 TCGA−17−Z016−01A−01W−0746−08 27180 24621 24293 24278 24276 21462 TCGA−67−6215−01A−11D−1753−08 TCGA−64−5775−01A−01D−1625−08 TCGA−55−1595−01A−01D−0969−08 TCGA−49−4510−01A−01D−1265−08 TCGA−49−4507−01A−01D−1265−08 TCGA−49−4486−01A−01D−1265−08 TCGA−17−Z017−01A−01W−0746−08 TCGA−05−4417−01A−22D−1855−08 27207 24694 24687 24680 24662 24605 21451

TCGA−17−Z058−01A−01W−0747−08 TCGA−44−3398−01A−01D−1105−08 TCGA−50−5932−01A−11D−1753−08 TCGA−73−4658−01A−01D−1753−08 TCGA−05−5715−01A−01D−1625−08 TCGA−75−5126−01A−01D−1753−08 TCGA−17−Z033−01A−01W−0746−08 TCGA−44−2655−01 TCGA−17−Z032−01A−01W−0746−08 TCGA−17−Z000−01A−01W−0746−08 TCGA−50−5072−01A−21D−1855−08 TCGA−73−4677−01A−01D−1265−08 TCGA−05−5420−01A−01D−1625−08 27235 TCGA−73−4668−01A−01D−1265−08 TCGA−64−5781−01A−01D−1625−08 TCGA−49−4488−01A−01D−1753−08 TCGA−64−5774−01A−01D−1625−08 TCGA−55−6642−01A−11D−1855−08 TCGA−05−4244−01A−01D−1105−08 TCGA−73−4659−01A−01D−1265−08 TCGA−67−6215−01A−11D−1753−08 TCGA−55−1595−01A−01D−0969−08 TCGA−49−4510−01A−01D−1265−08 TCGA−49−4507−01A−01D−1265−08 TCGA−49−4486−01A−01D−1265−08 TCGA−17−Z016−01A−01W−0746−08 TCGA−17−Z014−01A−01W−0746−08 TCGA−05−4417−01A−22D−1855−08 TCGA−05−4390−01A−02D−1753−08 27207 27180 24694 24687 24680 24662 24605 24293 24278 24276 21462 21451 TCGA−05−4410−01A−21D−1855−08 TCGA−05−4382−01A−01D−1265−08 TCGA−91−6836−01A−21D−1855−08 TCGA−67−3771−01 TCGA−64−1678−01A−01W−0928−08 TCGA−50−6590−01A−12D−1855−08 TCGA−35−3621−01A−01D−0969−08 TCGA−17−Z049−01A−01W−0746−08 TCGA−17−Z045−01A−01W−0746−08 TCGA−05−4427−01A−21D−1855−08 TCGA−64−5775−01A−01D−1625−08 TCGA−49−6767−01A−11D−1855−08 TCGA−17−Z026−01A−01W−0746−08 TCGA−17−Z022−01A−01W−0746−08 TCGA−17−Z021−01A−01W−0746−08 TCGA−17−Z015−01A−01W−0746−08 TCGA−91−6829−01A−21D−1855−08 TCGA−75−5125−01A−01D−1753−08 TCGA−73−4666−01A−01D−1265−08 TCGA−67−3770−01 TCGA−64−5778−01A−01D−1625−08 TCGA−55−1596−01 TCGA−55−1592−01 TCGA−50−6593−01A−11D−1753−08 TCGA−50−6591−01A−11D−1753−08 TCGA−50−5066−01A−01D−1625−08 TCGA−50−5049−01A−01D−1625−08 TCGA−50−5045−01A−01D−1625−08 TCGA−49−4487−01A−21D−1855−08 TCGA−44−6778−01A−11D−1855−08 TCGA−44−6777−01A−11D−1855−08 TCGA−44−6774−01A−21D−1855−08 TCGA−44−6145−01A−11D−1753−08 TCGA−44−2668−01 TCGA−44−2659−01 TCGA−38−4630−01A−01D−1265−08 TCGA−38−4629−01A−02D−1265−08 TCGA−38−4625−01A−01D−1553−08 TCGA−17−Z062−01A−01W−0747−08 TCGA−17−Z056−01A−01W−0747−08 TCGA−17−Z055−01A−01W−0747−08 TCGA−17−Z053−01A−01W−0747−08 TCGA−17−Z043−01A−01W−0746−08 TCGA−17−Z028−01A−01W−0746−08 TCGA−17−Z017−01A−01W−0746−08 TCGA−17−Z012−01A−01W−0746−08 TCGA−05−4426−01A−01D−1265−08 TCGA−05−4424−01A−22D−1855−08 TCGA−05−4420−01A−01D−1265−08 TCGA−05−4397−01A−01D−1265−08 TCGA−05−4395−01A−01D−1265−08 TCGA−05−4384−01A−01D−1753−08 24621 TCGA−91−6831−01A−11D−1855−08 TCGA−75−6211−01A−11D−1753−08 TCGA−75−6207−01A−11D−1753−08 TCGA−75−5147−01A−01D−1625−08 TCGA−75−5146−01A−01D−1625−08 TCGA−73−4676−01A−01D−1753−08 TCGA−73−4670−01A−01D−1265−08 TCGA−64−1677−01A−01W−0928−08 TCGA−64−1676−01 TCGA−55−6712−01A−11D−1855−08 TCGA−55−5899−01A−11D−1625−08 TCGA−55−1594−01 TCGA−50−6595−01A−12D−1855−08 TCGA−50−6594−01A−11D−1753−08 TCGA−50−6592−01A−11D−1753−08 TCGA−50−5946−01A−11D−1753−08 TCGA−50−5944−01A−11D−1753−08 TCGA−50−5941−01A−11D−1753−08 TCGA−50−5939−01A−11D−1625−08 TCGA−50−5933−01A−11D−1753−08 TCGA−50−5931−01A−11D−1753−08 TCGA−50−5068−01A−01D−1625−08 TCGA−49−4514−01A−21D−1855−08 TCGA−49−4505−01A−01D−1265−08 TCGA−49−4490−01A−21D−1855−08 TCGA−44−6779−01A−11D−1855−08 TCGA−44−6775−01A−11D−1855−08 TCGA−44−6147−01A−11D−1753−08 TCGA−44−6144−01A−11D−1753−08 TCGA−44−5645−01A−01D−1625−08 TCGA−44−5643−01A−01D−1625−08 TCGA−44−3918−01A−01D−1105−08 TCGA−44−3396−01A−01D−1265−08 TCGA−44−2666−01 TCGA−44−2662−01 TCGA−44−2656−01 TCGA−38−6178−01A−11D−1753−08 TCGA−38−4632−01A−01D−1753−08 TCGA−35−5375−01A−01D−1625−08 TCGA−35−4123−01A−01D−1105−08 TCGA−35−4122−01A−01D−1105−08 TCGA−17−Z061−01A−01W−0747−08 TCGA−17−Z057−01A−01W−0747−08 TCGA−17−Z052−01A−01W−0747−08 TCGA−17−Z047−01A−01W−0747−08 TCGA−17−Z046−01A−01W−0746−08 TCGA−17−Z044−01A−01W−0746−08 TCGA−17−Z042−01A−01W−0746−08 TCGA−17−Z037−01A−01W−0746−08 TCGA−17−Z035−01A−01W−0746−08 TCGA−17−Z030−01A−01W−0746−08 TCGA−17−Z027−01A−01W−0746−08 TCGA−17−Z023−01A−01W−0746−08 TCGA−17−Z020−01A−01W−0746−08 TCGA−17−Z007−01A−01W−0746−08 TCGA−17−Z005−01A−01W−0746−08 TCGA−17−Z003−01A−01W−0746−08 TCGA−17−Z001−01A−01W−0746−08 TCGA−05−5428−01A−01D−1625−08 TCGA−05−5423−01A−01D−1625−08 TCGA−05−4433−01A−22D−1855−08 TCGA−05−4432−01A−01D−1265−08 TCGA−05−4430−01A−02D−1265−08 TCGA−05−4405−01A−21D−1855−08 TCGA−05−4402−01A−01D−1265−08 TCGA−05−4398−01A−01D−1265−08 27224 27210 27206 27201 27197 27193 27188 27185 27182 27178 27175 27173 24693 24689 24682 24681 24678 24669 24667 24665 24663 24656 24653 24633 24625 24623 24617 24607 24600 24599 24598 24597 24486 24468 24331 24320 24319 24317 24312 24302 24301 24295 24292 24291 24289 24279 24270 24269 24256 24252 24250 24245 24239 24238 24205 24177 21472 21468 21454 21452 21442 21438

HDR Through Single Strand Annealing (SSA) FDR = 0.14%, FDR nod = 0.41% HDR Through Homologous Recombination (HRR) FDR = 1.2%, FDR nod = 1.3%

TCGA−17−Z013−01A−01W−0746−08 TCGA−50−5066−01A−01D−1625−08 TCGA−73−4666−01A−01D−1265−08 TCGA−17−Z020−01A−01W−0746−08 TCGA−17−Z056−01A−01W−0747−08 TCGA−64−1678−01A−01W−0928−08 TCGA−38−4626−01A−01D−1553−08 TCGA−50−6594−01A−11D−1753−08 TCGA−05−4403−01A−01D−1265−08 TCGA−73−4670−01A−01D−1265−08 TCGA−17−Z003−01A−01W−0746−08 TCGA−49−6767−01A−11D−1855−08 TCGA−38−4632−01A−01D−1753−08 TCGA−91−6828−01A−11D−1855−08 TCGA−44−3918−01A−01D−1105−08 TCGA−49−4487−01A−21D−1855−08 TCGA−44−6147−01A−11D−1753−08 TCGA−05−4425−01A−01D−1753−08 TCGA−44−2656−01 TCGA−50−6597−01A−11D−1855−08 TCGA−05−4415−01A−22D−1855−08 TCGA−67−4679−01B−01D−1753−08 24223 21461 TCGA−55−1592−01 TCGA−44−6145−01A−11D−1753−08 TCGA−38−4630−01A−01D−1265−08 TCGA−38−4625−01A−01D−1553−08 TCGA−44−6775−01A−11D−1855−08 TCGA−64−5779−01A−01D−1625−08 TCGA−50−5044−01A−21D−1855−08 TCGA−05−4250−01A−01D−1105−08 TCGA−35−3621−01A−01D−0969−08 TCGA−64−5781−01A−01D−1625−08 TCGA−50−5072−01A−21D−1855−08 TCGA−49−4494−01A−01D−1265−08 TCGA−17−Z055−01A−01W−0747−08 TCGA−50−5045−01A−01D−1625−08 TCGA−44−3398−01A−01D−1105−08 TCGA−17−Z049−01A−01W−0746−08 TCGA−17−Z045−01A−01W−0746−08 TCGA−17−Z026−01A−01W−0746−08 TCGA−80−5611−01A−01D−1625−08 TCGA−50−6593−01A−11D−1753−08 TCGA−44−3396−01A−01D−1265−08 TCGA−17−Z042−01A−01W−0746−08 24625 TCGA−50−5049−01A−01D−1625−08 TCGA−75−5126−01A−01D−1753−08 TCGA−49−6742−01A−11D−1855−08 TCGA−17−Z030−01A−01W−0746−08 24298 24181 TCGA−05−4410−01A−21D−1855−08 TCGA−17−Z046−01A−01W−0746−08 TCGA−05−4427−01A−21D−1855−08 TCGA−73−4658−01A−01D−1753−08 TCGA−44−2665−01 TCGA−44−2661−01A−01D−1105−08 TCGA−38−4631−01A−01D−1753−08 TCGA−05−4418−01A−01D−1265−08 TCGA−05−4389−01A−01D−1265−08 TCGA−17−Z022−01A−01W−0746−08 TCGA−05−4398−01A−01D−1265−08 TCGA−64−1677−01A−01W−0928−08 TCGA−17−Z023−01A−01W−0746−08 TCGA−05−4424−01A−22D−1855−08 TCGA−91−6829−01A−21D−1855−08 TCGA−44−6779−01A−11D−1855−08 TCGA−44−2668−01 TCGA−17−Z060−01A−01W−0747−08 TCGA−17−Z043−01A−01W−0746−08 TCGA−17−Z015−01A−01W−0746−08 TCGA−17−Z010−01A−01W−0746−08 TCGA−05−4402−01A−01D−1265−08 27201 TCGA−05−4382−01A−01D−1265−08 TCGA−64−5775−01A−01D−1625−08 TCGA−55−1595−01A−01D−0969−08 TCGA−05−4390−01A−02D−1753−08 TCGA−05−4244−01A−01D−1105−08 TCGA−91−6836−01A−21D−1855−08 TCGA−73−4659−01A−01D−1265−08 TCGA−67−6215−01A−11D−1753−08 TCGA−64−5774−01A−01D−1625−08 TCGA−55−6642−01A−11D−1855−08 TCGA−49−4510−01A−01D−1265−08 TCGA−49−4507−01A−01D−1265−08 TCGA−49−4486−01A−01D−1265−08 TCGA−17−Z062−01A−01W−0747−08 TCGA−17−Z017−01A−01W−0746−08 TCGA−17−Z016−01A−01W−0746−08 TCGA−17−Z014−01A−01W−0746−08 TCGA−05−4417−01A−22D−1855−08 27207 27180 24694 24687 24680 24662 24621 24605 24293 24278 24276 21462 21451

TCGA−17−Z013−01A−01W−0746−08 TCGA−50−5066−01A−01D−1625−08 TCGA−73−4666−01A−01D−1265−08 TCGA−05−4405−01A−21D−1855−08 TCGA−17−Z020−01A−01W−0746−08 TCGA−50−5939−01A−11D−1625−08 TCGA−73−4668−01A−01D−1265−08 TCGA−64−1678−01A−01W−0928−08 TCGA−73−4670−01A−01D−1265−08 TCGA−17−Z003−01A−01W−0746−08 TCGA−38−4626−01A−01D−1553−08 TCGA−44−6776−01A−11D−1855−08 TCGA−44−6144−01A−11D−1753−08 TCGA−35−4123−01A−01D−1105−08 TCGA−50−6597−01A−11D−1855−08 TCGA−05−4415−01A−22D−1855−08 TCGA−50−5044−01A−21D−1855−08 TCGA−05−4250−01A−01D−1105−08 TCGA−91−6829−01A−21D−1855−08 TCGA−64−1676−01 TCGA−49−4514−01A−21D−1855−08 TCGA−50−5045−01A−01D−1625−08 TCGA−17−Z049−01A−01W−0746−08 TCGA−17−Z045−01A−01W−0746−08 TCGA−49−4487−01A−21D−1855−08 TCGA−44−6147−01A−11D−1753−08 TCGA−05−4425−01A−01D−1753−08 TCGA−55−1592−01 TCGA−44−6145−01A−11D−1753−08 TCGA−38−4630−01A−01D−1265−08 TCGA−38−4625−01A−01D−1553−08 TCGA−75−5126−01A−01D−1753−08 TCGA−49−6742−01A−11D−1855−08 TCGA−17−Z030−01A−01W−0746−08 24298 TCGA−44−6775−01A−11D−1855−08 TCGA−17−Z056−01A−01W−0747−08 TCGA−67−3771−01 TCGA−49−6767−01A−11D−1855−08 TCGA−05−5420−01A−01D−1625−08 TCGA−50−5049−01A−01D−1625−08 TCGA−44−2656−01 TCGA−17−Z055−01A−01W−0747−08 TCGA−64−5779−01A−01D−1625−08 TCGA−44−3398−01A−01D−1105−08 TCGA−49−6743−01A−11D−1855−08 TCGA−17−Z046−01A−01W−0746−08 TCGA−05−4410−01A−21D−1855−08 TCGA−73−4658−01A−01D−1753−08 TCGA−44−2665−01 TCGA−44−2661−01A−01D−1105−08 TCGA−05−4418−01A−01D−1265−08 TCGA−05−4389−01A−01D−1265−08 TCGA−17−Z026−01A−01W−0746−08 TCGA−80−5611−01A−01D−1625−08 TCGA−50−6593−01A−11D−1753−08 TCGA−44−3396−01A−01D−1265−08 TCGA−17−Z042−01A−01W−0746−08 TCGA−05−4424−01A−22D−1855−08 24625 TCGA−64−1677−01A−01W−0928−08 TCGA−50−6592−01A−11D−1753−08 TCGA−44−6777−01A−11D−1855−08 TCGA−35−4122−01A−01D−1105−08 TCGA−55−6712−01A−11D−1855−08 TCGA−44−3918−01A−01D−1105−08 TCGA−44−2668−01 TCGA−05−4395−01A−01D−1265−08 TCGA−35−3621−01A−01D−0969−08 TCGA−05−4427−01A−21D−1855−08 TCGA−17−Z022−01A−01W−0746−08 TCGA−38−4631−01A−01D−1753−08 24181 TCGA−75−6211−01A−11D−1753−08 TCGA−73−4662−01A−01D−1265−08 TCGA−44−3919−01 TCGA−17−Z057−01A−01W−0747−08 TCGA−17−Z025−01A−01W−0746−08 TCGA−17−Z023−01A−01W−0746−08 TCGA−05−4397−01A−01D−1265−08 27206 TCGA−05−4382−01A−01D−1265−08 TCGA−91−6836−01A−21D−1855−08 TCGA−05−4390−01A−02D−1753−08 TCGA−67−6215−01A−11D−1753−08 TCGA−64−5775−01A−01D−1625−08 TCGA−49−4486−01A−01D−1265−08 TCGA−05−4244−01A−01D−1105−08 TCGA−73−4659−01A−01D−1265−08 TCGA−64−5774−01A−01D−1625−08 TCGA−55−6642−01A−11D−1855−08 TCGA−55−1595−01A−01D−0969−08 TCGA−49−4510−01A−01D−1265−08 TCGA−49−4507−01A−01D−1265−08 TCGA−17−Z062−01A−01W−0747−08 TCGA−17−Z017−01A−01W−0746−08 TCGA−17−Z016−01A−01W−0746−08 TCGA−17−Z014−01A−01W−0746−08 TCGA−05−4417−01A−22D−1855−08 27207 27180 24694 24687 24680 24662 24621 24605 24293 24278 24276 21462 21451

ATM

unknown CG mut

unknown CG mut

BRCA2

known HCG mut BRCA1

PALB2

DNA2

MRE11A

RAD51C

RAD51AP1

BLM

NBN

RAD50

RAD51

RAD51D

RBBP8

EXO1

RAD51B

RTEL1

wt

TOP3A

known HCG mut

wt BARD1

BRIP1

TP53 ATM EGFR NF1 BRAF SMARCA4 CTNNB1 TPR APOBEC3G MMP1 PTEN RB1 SMAD4 ATR BARD1 BLM FILIP1 SMAD2 ZMYND8 ALKBH1 ARAF CHEK1 E2F1 FER JAK1 MDM2 PAK1 PIK3R2 RALA TGFBR1 USP15 WEE1 AKT1 AR BACH1 BCL2 BID BMPR2 BRCA1 CCNB1IP1 CCND1 CDC25A CDC25B CDK4 CERK CHEK2 CHUK EDAR FOSL2 GSK3A HDAC1 HIPK2 JAKMIP1 LGALS13 MAX MSH2 MYC MYT1 NAB1 NFKB1 NOXA1 ODC1 PIAS1 PKIA PLK1 PML RAD51 RHEB RRAS SIRT1 SMAD1 STAT1 TAB1 TSC1 USP16 USP21 ZMIZ1 WRN

Integrated Breast Cancer Pathway FDR = 2e−12%, FDR nod = 0.23% Homologous DNA Pairing And Strand Exchange Resolution Of D Loop Structures Through Synthesis Dependent Strand Annealing (SDSA) FDR = 1.1%, FDR nod = 1.1%

wt ABL1 wt

wt wt

known HCG mut BRCA1 known HCG mut


unknown CG mut ATM unknown CG mut

ATR

WRN

BARD1

MRE11A ATRIP BLM

TOP3A BRIP1 DNA2

ERCC4 RAD17 RFC2

TOPBP1 EXO1 NBN

RAD50

RAD51

RAD9A RBBP8 HUS1

RAD1

RAD52 RFC3

RFC5

RHNO1 RPA2

ATM BRCA2 POLE BRCA1 WRN PALB2 UBC BARD1 TOP3A DNA2 MRE11A RFC1 BLM BRIP1 POLD2 RAD51AP1 RFC2 NBN POLD1 POLK RAD51 RAD51C RAD51D RBBP8 EXO1 PCNA POLD4 POLE2 RAD50 RAD51B RFC3 RFC5 RPA2

unknown CG mut ATM CDKN2A RB1 TRRAP RBL1 CES5A TFDP1 WASF1 SMARCA2 BRCA1 CDKN1B E2F1 E2F7 MCM3 TOPBP1 CCNE1 CDK1 CES1 CES3 HDAC1 KAT2B MYBL2 SERPINE1 TP73 XRCC1 APAF1 CBX5 CCNA2 CDC25A CREBBP E2F3 E2F6 KAT2A MYC ORC1 POLA1 PRMT5 RBBP8 SULT2A1 CDKN1A CES2 CES4A DHFR E2F8 EP300 MAD2L1BP PLAU PTGDR RBBP4 RBL2 RRM1 RRM2 RYBP SIRT1 TFDP2 TFE3 TRIM28 UXT YY1 unknown CG mut TP53 ATM EP400 CCNE1 HIST2H2AC POT1 ACD HIST1H2AB HIST1H2AC HIST1H2BC HIST1H2BI HIST1H4J MRE11A CCNA1 CCNA2 CDKN1A CDKN1B H2AFX HIST1H2AE HIST1H2AJ HIST1H2BF HIST1H2BH HIST1H2BJ HIST1H2BL HIST1H2BN HIST1H4B HIST1H4D HIST1H4E HIST1H4H HIST1H4I HIST1H4L HIST2H2BE HIST3H2BB NBN RAD50 TERF1 TINF2

TCGA−49−6743−01A−11D−1855−08 TCGA−75−5122−01A−01D−1753−08 TCGA−49−4501−01A−01D−1265−08 24225 TCGA−44−2655−01 27177 TCGA−49−6744−01A−11D−1855−08 24267 TCGA−73−4662−01A−01D−1265−08 24579 TCGA−73−4677−01A−01D−1265−08 TCGA−44−6776−01A−11D−1855−08 TCGA−50−5935−01A−11D−1753−08 TCGA−35−3615−01 TCGA−73−4668−01A−01D−1265−08 TCGA−50−5051−01A−21D−1855−08 TCGA−49−6745−01A−11D−1855−08 27192 TCGA−71−6725−01A−11D−1855−08 TCGA−17−Z059−01A−01W−0747−08 TCGA−05−4250−01A−01D−1105−08 TCGA−64−5779−01A−01D−1625−08 TCGA−75−5126−01A−01D−1753−08 24298 TCGA−17−Z060−01A−01W−0747−08 TCGA−17−Z010−01A−01W−0746−08 TCGA−05−5429−01A−01D−1625−08 TCGA−67−6216−01A−11D−1753−08 TCGA−05−5715−01A−01D−1625−08 TCGA−91−6828−01A−11D−1855−08 TCGA−17−Z051−01A−01W−0747−08 TCGA−05−4415−01A−22D−1855−08 TCGA−44−3398−01A−01D−1105−08 24609 24261 TCGA−17−Z036−01A−01W−0746−08 TCGA−67−3773−01 TCGA−17−Z033−01A−01W−0746−08 TCGA−67−3774−01 TCGA−75−6206−01A−11D−1753−08 TCGA−44−3919−01 TCGA−64−5781−01A−01D−1625−08 TCGA−17−Z025−01A−01W−0746−08 TCGA−50−6597−01A−11D−1855−08 TCGA−50−5055−01A−01D−1625−08 TCGA−44−4112−01 TCGA−67−4679−01B−01D−1753−08 TCGA−05−4422−01A−01D−1265−08 TCGA−05−4425−01A−01D−1753−08 24333 24318 TCGA−80−5611−01A−01D−1625−08 TCGA−49−6742−01A−11D−1855−08 TCGA−17−Z018−01A−01W−0746−08 TCGA−55−6543−01A−11D−1753−08 TCGA−50−5936−01A−11D−1625−08 TCGA−17−Z000−01A−01W−0746−08 TCGA−05−5420−01A−01D−1625−08 TCGA−50−5044−01A−21D−1855−08 TCGA−05−4389−01A−01D−1265−08 TCGA−50−5942−01A−21D−1753−08 TCGA−17−Z008−01A−01W−0746−08 TCGA−05−4249−01A−01D−1105−08 24666 24268 TCGA−38−4631−01A−01D−1753−08 TCGA−50−5072−01A−21D−1855−08 24181 TCGA−73−4658−01A−01D−1753−08 TCGA−44−2657−01A−01D−1105−08 TCGA−49−4488−01A−01D−1753−08 TCGA−17−Z040−01A−01W−0746−08 27235 24330 21453 TCGA−17−Z032−01A−01W−0746−08 TCGA−91−6835−01A−11D−1855−08 24200 24193 TCGA−67−6217−01A−11D−1753−08 TCGA−67−3772−01A−01W−0928−08 TCGA−49−4494−01A−01D−1265−08 TCGA−38−4628−01A−01D−1265−08 TCGA−38−4627−01A−01D−1553−08 27194 27186 24629 24626 24326 24296 24231 24230 24218 24208 TCGA−05−4417−01A−22D−1855−08 TCGA−73−4659−01A−01D−1265−08 TCGA−49−4510−01A−01D−1265−08 TCGA−49−4486−01A−01D−1265−08 TCGA−05−4390−01A−02D−1753−08 24694 24293 24276 21462 TCGA−67−6215−01A−11D−1753−08 TCGA−64−5774−01A−01D−1625−08 TCGA−55−6642−01A−11D−1855−08 TCGA−55−1595−01A−01D−0969−08 TCGA−49−4507−01A−01D−1265−08 TCGA−17−Z016−01A−01W−0746−08 TCGA−17−Z014−01A−01W−0746−08 TCGA−05−4244−01A−01D−1105−08 27207 27180 24687 24680 24662 24605 24278 21451 TCGA−05−4427−01A−21D−1855−08 TCGA−67−3771−01 TCGA−44−6775−01A−11D−1855−08 TCGA−91−6829−01A−21D−1855−08 TCGA−44−6774−01A−21D−1855−08 TCGA−17−Z022−01A−01W−0746−08 TCGA−05−4382−01A−01D−1265−08 21472 TCGA−91−6836−01A−21D−1855−08 TCGA−64−5775−01A−01D−1625−08 TCGA−50−6594−01A−11D−1753−08 TCGA−50−5941−01A−11D−1753−08 TCGA−17−Z062−01A−01W−0747−08 TCGA−17−Z015−01A−01W−0746−08 TCGA−05−4410−01A−21D−1855−08 TCGA−05−4397−01A−01D−1265−08 TCGA−64−1676−01 TCGA−50−6593−01A−11D−1753−08 TCGA−50−5933−01A−11D−1753−08 TCGA−50−5049−01A−01D−1625−08 TCGA−49−6767−01A−11D−1855−08 TCGA−44−3918−01A−01D−1105−08 TCGA−44−2668−01 TCGA−38−4625−01A−01D−1553−08 TCGA−35−4123−01A−01D−1105−08 TCGA−17−Z049−01A−01W−0746−08 TCGA−17−Z042−01A−01W−0746−08 TCGA−17−Z026−01A−01W−0746−08 TCGA−17−Z017−01A−01W−0746−08 TCGA−05−4432−01A−01D−1265−08 TCGA−05−4424−01A−22D−1855−08 TCGA−05−4398−01A−01D−1265−08 24621 TCGA−91−6831−01A−11D−1855−08 TCGA−75−6211−01A−11D−1753−08 TCGA−73−4676−01A−01D−1753−08 TCGA−73−4666−01A−01D−1265−08 TCGA−67−3770−01 TCGA−64−1677−01A−01W−0928−08 TCGA−55−1592−01 TCGA−50−5931−01A−11D−1753−08 TCGA−49−4514−01A−21D−1855−08 TCGA−49−4490−01A−21D−1855−08 TCGA−44−6145−01A−11D−1753−08 TCGA−44−6144−01A−11D−1753−08 TCGA−44−3396−01A−01D−1265−08 TCGA−44−2662−01 TCGA−44−2656−01 TCGA−38−4629−01A−02D−1265−08 TCGA−35−5375−01A−01D−1625−08 TCGA−35−3621−01A−01D−0969−08 TCGA−17−Z055−01A−01W−0747−08 TCGA−17−Z047−01A−01W−0747−08 TCGA−17−Z046−01A−01W−0746−08 TCGA−17−Z045−01A−01W−0746−08 TCGA−17−Z043−01A−01W−0746−08 TCGA−17−Z035−01A−01W−0746−08 TCGA−17−Z027−01A−01W−0746−08 TCGA−05−5428−01A−01D−1625−08 TCGA−05−4405−01A−21D−1855−08 27173 24331 24317 24177 21468 21438 TCGA−75−6207−01A−11D−1753−08 TCGA−75−5146−01A−01D−1625−08 TCGA−75−5125−01A−01D−1753−08 TCGA−64−5778−01A−01D−1625−08 TCGA−64−1678−01A−01W−0928−08 TCGA−55−6712−01A−11D−1855−08 TCGA−55−5899−01A−11D−1625−08 TCGA−55−1596−01 TCGA−55−1594−01 TCGA−50−6595−01A−12D−1855−08 TCGA−50−6592−01A−11D−1753−08 TCGA−50−6591−01A−11D−1753−08 TCGA−50−6590−01A−12D−1855−08 TCGA−50−5946−01A−11D−1753−08 TCGA−50−5944−01A−11D−1753−08 TCGA−50−5068−01A−01D−1625−08 TCGA−50−5066−01A−01D−1625−08 TCGA−50−5045−01A−01D−1625−08 TCGA−44−6779−01A−11D−1855−08 TCGA−44−6777−01A−11D−1855−08 TCGA−44−6147−01A−11D−1753−08 TCGA−44−2666−01 TCGA−44−2659−01 TCGA−38−6178−01A−11D−1753−08 TCGA−38−4630−01A−01D−1265−08 TCGA−35−4122−01A−01D−1105−08 TCGA−17−Z061−01A−01W−0747−08 TCGA−17−Z057−01A−01W−0747−08 TCGA−17−Z056−01A−01W−0747−08 TCGA−17−Z053−01A−01W−0747−08 TCGA−17−Z044−01A−01W−0746−08 TCGA−17−Z037−01A−01W−0746−08 TCGA−17−Z030−01A−01W−0746−08 TCGA−17−Z028−01A−01W−0746−08 TCGA−17−Z023−01A−01W−0746−08 TCGA−17−Z020−01A−01W−0746−08 TCGA−17−Z012−01A−01W−0746−08 TCGA−17−Z007−01A−01W−0746−08 TCGA−05−5423−01A−01D−1625−08 TCGA−05−4420−01A−01D−1265−08 TCGA−05−4402−01A−01D−1265−08 TCGA−05−4384−01A−01D−1753−08 27210 27206 27201 27197 24682 24678 24667 24656 24633 24625 24617 24600 24599 24598 24319 24302 24301 24295 24291 24256 24239 21454 TCGA−75−5147−01A−01D−1625−08 TCGA−73−4670−01A−01D−1265−08 TCGA−50−5939−01A−11D−1625−08 TCGA−49−4505−01A−01D−1265−08 TCGA−49−4487−01A−21D−1855−08 TCGA−44−6778−01A−11D−1855−08 TCGA−44−5645−01A−01D−1625−08 TCGA−44−5643−01A−01D−1625−08 TCGA−38−4632−01A−01D−1753−08 TCGA−17−Z052−01A−01W−0747−08 TCGA−17−Z021−01A−01W−0746−08 TCGA−17−Z005−01A−01W−0746−08 TCGA−17−Z003−01A−01W−0746−08 TCGA−17−Z001−01A−01W−0746−08 TCGA−05−4433−01A−22D−1855−08 TCGA−05−4430−01A−02D−1265−08 TCGA−05−4426−01A−01D−1265−08 TCGA−05−4395−01A−01D−1265−08 27224 27193 27188 27185 27182 27178 27175 24693 24689 24681 24669 24665 24663 24653 24623 24607 24597 24486 24468 24320 24312 24292 24289 24279 24270 24269 24252 24250 24245 24238 24205 21452 21442

TCGA−44−2662−01 TCGA−50−5066−01A−01D−1625−08 TCGA−73−4666−01A−01D−1265−08 TCGA−17−Z020−01A−01W−0746−08 TCGA−17−Z056−01A−01W−0747−08 TCGA−64−1678−01A−01W−0928−08 TCGA−05−4250−01A−01D−1105−08 TCGA−38−4626−01A−01D−1553−08 TCGA−44−6776−01A−11D−1855−08 TCGA−50−5044−01A−21D−1855−08 TCGA−44−6777−01A−11D−1855−08 TCGA−05−4405−01A−21D−1855−08 TCGA−50−5045−01A−01D−1625−08 TCGA−17−Z049−01A−01W−0746−08 TCGA−17−Z045−01A−01W−0746−08 TCGA−49−4487−01A−21D−1855−08 TCGA−44−6147−01A−11D−1753−08 TCGA−05−4425−01A−01D−1753−08 TCGA−55−1592−01 TCGA−44−6145−01A−11D−1753−08 TCGA−38−4630−01A−01D−1265−08 TCGA−38−4625−01A−01D−1553−08 TCGA−44−6775−01A−11D−1855−08 TCGA−64−1677−01A−01W−0928−08 TCGA−50−6597−01A−11D−1855−08 TCGA−05−4415−01A−22D−1855−08 TCGA−75−5126−01A−01D−1753−08 TCGA−49−6742−01A−11D−1855−08 TCGA−17−Z030−01A−01W−0746−08 24298 TCGA−50−5049−01A−01D−1625−08 TCGA−17−Z055−01A−01W−0747−08 TCGA−64−5779−01A−01D−1625−08 TCGA−44−3398−01A−01D−1105−08 TCGA−44−2656−01 TCGA−49−6743−01A−11D−1855−08 TCGA−17−Z046−01A−01W−0746−08 TCGA−05−4410−01A−21D−1855−08 TCGA−73−4658−01A−01D−1753−08 TCGA−44−2665−01 TCGA−44−2661−01A−01D−1105−08 TCGA−05−4418−01A−01D−1265−08 TCGA−05−4389−01A−01D−1265−08 TCGA−17−Z026−01A−01W−0746−08 TCGA−80−5611−01A−01D−1625−08 TCGA−50−6593−01A−11D−1753−08 TCGA−44−3396−01A−01D−1265−08 TCGA−17−Z042−01A−01W−0746−08 TCGA−05−4424−01A−22D−1855−08 24625 TCGA−35−3621−01A−01D−0969−08 TCGA−05−4427−01A−21D−1855−08 TCGA−38−4631−01A−01D−1753−08 TCGA−17−Z022−01A−01W−0746−08 24181 TCGA−75−6211−01A−11D−1753−08 TCGA−73−4662−01A−01D−1265−08 TCGA−44−3919−01 TCGA−17−Z057−01A−01W−0747−08 TCGA−17−Z025−01A−01W−0746−08 TCGA−17−Z023−01A−01W−0746−08 TCGA−05−4397−01A−01D−1265−08 27206 TCGA−05−4382−01A−01D−1265−08 TCGA−05−4390−01A−02D−1753−08 TCGA−64−5775−01A−01D−1625−08 TCGA−49−4486−01A−01D−1265−08 TCGA−05−4244−01A−01D−1105−08 TCGA−91−6836−01A−21D−1855−08 TCGA−73−4659−01A−01D−1265−08 TCGA−67−6215−01A−11D−1753−08 TCGA−64−5774−01A−01D−1625−08 TCGA−55−6642−01A−11D−1855−08 TCGA−55−1595−01A−01D−0969−08 TCGA−49−4510−01A−01D−1265−08 TCGA−49−4507−01A−01D−1265−08 TCGA−17−Z062−01A−01W−0747−08 TCGA−17−Z017−01A−01W−0746−08 TCGA−17−Z016−01A−01W−0746−08 TCGA−17−Z014−01A−01W−0746−08 TCGA−05−4417−01A−22D−1855−08 27207 27180 24694 24687 24680 24662 24621 24605 24293 24278 24276 21462 21451

Meiotic Recombination FDR = 8.2e−06%, FDR nod = 2.7e−05% Integrated Cancer Pathway FDR = 2e−12%, FDR nod = 0.23%

TCGA−64−1680−01 TCGA−17−Z020−01A−01W−0746−08 TCGA−17−Z056−01A−01W−0747−08 TCGA−50−6594−01A−11D−1753−08 TCGA−44−6146−01A−11D−1753−08 TCGA−44−3918−01A−01D−1105−08 TCGA−50−5932−01A−11D−1753−08 TCGA−91−6829−01A−21D−1855−08 TCGA−17−Z015−01A−01W−0746−08 TCGA−44−2668−01 TCGA−17−Z032−01A−01W−0746−08 TCGA−50−5944−01A−11D−1753−08 TCGA−05−4384−01A−01D−1753−08 TCGA−64−5781−01A−01D−1625−08 TCGA−17−Z053−01A−01W−0747−08 TCGA−05−5715−01A−01D−1625−08 TCGA−64−1678−01A−01W−0928−08 TCGA−64−5778−01A−01D−1625−08 TCGA−17−Z033−01A−01W−0746−08 TCGA−44−6145−01A−11D−1753−08 TCGA−38−4630−01A−01D−1265−08 TCGA−44−6777−01A−11D−1855−08 TCGA−49−6767−01A−11D−1855−08 TCGA−50−6591−01A−11D−1753−08 TCGA−44−6778−01A−11D−1855−08 TCGA−17−Z045−01A−01W−0746−08 TCGA−50−5045−01A−01D−1625−08 TCGA−44−3398−01A−01D−1105−08 TCGA−17−Z012−01A−01W−0746−08 TCGA−73−4677−01A−01D−1265−08 TCGA−50−5072−01A−21D−1855−08 TCGA−67−3771−01 TCGA−44−6147−01A−11D−1753−08 TCGA−17−Z048−01A−01W−0746−08 TCGA−05−4432−01A−01D−1265−08 TCGA−80−5611−01A−01D−1625−08 TCGA−44−3396−01A−01D−1265−08 TCGA−05−4424−01A−22D−1855−08 24625 TCGA−50−5044−01A−21D−1855−08 TCGA−05−4250−01A−01D−1105−08 TCGA−64−5779−01A−01D−1625−08 TCGA−44−6775−01A−11D−1855−08 TCGA−35−3621−01A−01D−0969−08 TCGA−17−Z022−01A−01W−0746−08 TCGA−73−4662−01A−01D−1265−08 TCGA−44−3919−01 TCGA−38−4631−01A−01D−1753−08 TCGA−17−Z057−01A−01W−0747−08 TCGA−17−Z025−01A−01W−0746−08 TCGA−17−Z023−01A−01W−0746−08 27206 24181 TCGA−05−4410−01A−21D−1855−08 TCGA−17−Z049−01A−01W−0746−08 TCGA−17−Z026−01A−01W−0746−08 TCGA−73−4668−01A−01D−1265−08 TCGA−73−4658−01A−01D−1753−08 TCGA−73−4666−01A−01D−1265−08 TCGA−55−1596−01 TCGA−49−6744−01A−11D−1855−08 TCGA−17−Z028−01A−01W−0746−08 TCGA−05−5428−01A−01D−1625−08 TCGA−05−4398−01A−01D−1265−08 TCGA−49−6743−01A−11D−1855−08 TCGA−44−2659−01 TCGA−35−4122−01A−01D−1105−08 TCGA−17−Z035−01A−01W−0746−08 TCGA−05−4430−01A−02D−1265−08 TCGA−05−4382−01A−01D−1265−08 TCGA−91−6836−01A−21D−1855−08 TCGA−64−5775−01A−01D−1625−08 TCGA−55−6642−01A−11D−1855−08 TCGA−55−1595−01A−01D−0969−08 TCGA−49−4486−01A−01D−1265−08 TCGA−17−Z062−01A−01W−0747−08 TCGA−05−4417−01A−22D−1855−08 TCGA−05−4244−01A−01D−1105−08 TCGA−73−4659−01A−01D−1265−08 TCGA−67−6215−01A−11D−1753−08 TCGA−64−5774−01A−01D−1625−08 TCGA−49−4510−01A−01D−1265−08 TCGA−49−4507−01A−01D−1265−08 TCGA−17−Z017−01A−01W−0746−08 TCGA−17−Z014−01A−01W−0746−08 TCGA−05−4390−01A−02D−1753−08 27207 27180 24694 24687 24680 24662 24621 24605 24293 24278 24276 21462 21451 TCGA−50−6590−01A−12D−1855−08 TCGA−38−4625−01A−01D−1553−08 TCGA−50−5066−01A−01D−1625−08 TCGA−05−4405−01A−21D−1855−08 TCGA−05−4397−01A−01D−1265−08 TCGA−55−1592−01 TCGA−50−6593−01A−11D−1753−08 TCGA−50−5933−01A−11D−1753−08 TCGA−50−5049−01A−01D−1625−08 TCGA−17−Z042−01A−01W−0746−08 TCGA−17−Z030−01A−01W−0746−08 TCGA−05−4427−01A−21D−1855−08 TCGA−75−6211−01A−11D−1753−08 TCGA−75−5126−01A−01D−1753−08 TCGA−50−6592−01A−11D−1753−08 TCGA−49−4487−01A−21D−1855−08 TCGA−17−Z055−01A−01W−0747−08 TCGA−17−Z016−01A−01W−0746−08 TCGA−05−4395−01A−01D−1265−08 TCGA−73−4676−01A−01D−1753−08 TCGA−64−5815−01A−01D−1625−08 TCGA−55−6712−01A−11D−1855−08 TCGA−49−6742−01A−11D−1855−08 TCGA−49−4494−01A−01D−1265−08 TCGA−49−4488−01A−01D−1753−08 TCGA−38−4632−01A−01D−1753−08 TCGA−17−Z061−01A−01W−0747−08 TCGA−17−Z060−01A−01W−0747−08 TCGA−17−Z051−01A−01W−0747−08 TCGA−17−Z040−01A−01W−0746−08 TCGA−17−Z018−01A−01W−0746−08 TCGA−17−Z008−01A−01W−0746−08 TCGA−05−4249−01A−01D−1105−08

TCGA−50−5931−01A−11D−1753−08 TCGA−91−6828−01A−11D−1855−08 TCGA−49−6744−01A−11D−1855−08 TCGA−50−6597−01A−11D−1855−08 TCGA−17−Z010−01A−01W−0746−08 TCGA−05−4405−01A−21D−1855−08 TCGA−50−5941−01A−11D−1753−08 TCGA−17−Z003−01A−01W−0746−08 TCGA−55−6712−01A−11D−1855−08 TCGA−05−4395−01A−01D−1265−08 TCGA−50−5932−01A−11D−1753−08 TCGA−55−1596−01 TCGA−17−Z015−01A−01W−0746−08 TCGA−17−Z053−01A−01W−0747−08 TCGA−55−1592−01 TCGA−17−Z023−01A−01W−0746−08 TCGA−05−4410−01A−21D−1855−08 TCGA−05−4427−01A−21D−1855−08 TCGA−44−6777−01A−11D−1855−08 TCGA−17−Z057−01A−01W−0747−08 TCGA−35−3621−01A−01D−0969−08 TCGA−50−5066−01A−01D−1625−08 TCGA−50−6591−01A−11D−1753−08 TCGA−05−4384−01A−01D−1753−08 TCGA−50−6594−01A−11D−1753−08 TCGA−05−4432−01A−01D−1265−08 TCGA−44−2659−01 TCGA−44−2656−01 TCGA−17−Z049−01A−01W−0746−08 TCGA−17−Z045−01A−01W−0746−08 TCGA−44−3398−01A−01D−1105−08 TCGA−50−5049−01A−01D−1625−08 24298 24181 TCGA−05−5715−01A−01D−1625−08 TCGA−67−3772−01A−01W−0928−08 TCGA−49−4488−01A−01D−1753−08 TCGA−17−Z046−01A−01W−0746−08 TCGA−73−4670−01A−01D−1265−08 TCGA−49−4505−01A−01D−1265−08 TCGA−17−Z060−01A−01W−0747−08 TCGA−05−4389−01A−01D−1265−08 TCGA−91−6835−01A−11D−1855−08 TCGA−55−5899−01A−11D−1625−08 TCGA−50−5933−01A−11D−1753−08 TCGA−50−5072−01A−21D−1855−08 TCGA−38−4628−01A−01D−1265−08 TCGA−05−4424−01A−22D−1855−08 TCGA−50−6593−01A−11D−1753−08 TCGA−44−3396−01A−01D−1265−08 TCGA−17−Z042−01A−01W−0746−08 24625 TCGA−50−6590−01A−12D−1855−08 TCGA−49−6767−01A−11D−1855−08 TCGA−64−5815−01A−01D−1625−08 TCGA−64−1676−01 TCGA−44−3918−01A−01D−1105−08 TCGA−17−Z012−01A−01W−0746−08 TCGA−91−6831−01A−11D−1855−08 TCGA−73−4668−01A−01D−1265−08 TCGA−64−5781−01A−01D−1625−08 TCGA−80−5611−01A−01D−1625−08 TCGA−38−4625−01A−01D−1553−08 TCGA−44−2662−01 TCGA−35−4122−01A−01D−1105−08 TCGA−17−Z061−01A−01W−0747−08 TCGA−17−Z051−01A−01W−0747−08 TCGA−17−Z043−01A−01W−0746−08 TCGA−67−3771−01 TCGA−17−Z026−01A−01W−0746−08 TCGA−75−5125−01A−01D−1753−08 TCGA−17−Z030−01A−01W−0746−08 TCGA−75−6211−01A−11D−1753−08 TCGA−73−4666−01A−01D−1265−08 TCGA−50−5045−01A−01D−1625−08 TCGA−38−4632−01A−01D−1753−08 TCGA−17−Z022−01A−01W−0746−08 TCGA−05−4398−01A−01D−1265−08 TCGA−49−4494−01A−01D−1265−08 TCGA−49−4487−01A−21D−1855−08 TCGA−44−2668−01 TCGA−44−2657−01A−01D−1105−08 TCGA−38−4629−01A−02D−1265−08 TCGA−17−Z048−01A−01W−0746−08 TCGA−17−Z018−01A−01W−0746−08 TCGA−05−4249−01A−01D−1105−08 TCGA−49−6742−01A−11D−1855−08 TCGA−05−4397−01A−01D−1265−08 TCGA−64−5779−01A−01D−1625−08 TCGA−64−1678−01A−01W−0928−08 TCGA−17−Z056−01A−01W−0747−08 TCGA−17−Z028−01A−01W−0746−08 TCGA−91−6829−01A−21D−1855−08 TCGA−75−5126−01A−01D−1753−08 TCGA−73−4658−01A−01D−1753−08 TCGA−17−Z055−01A−01W−0747−08 TCGA−05−4250−01A−01D−1105−08 TCGA−73−4677−01A−01D−1265−08 TCGA−44−4112−01 TCGA−44−2661−01A−01D−1105−08 TCGA−38−6178−01A−11D−1753−08 TCGA−17−Z021−01A−01W−0746−08 TCGA−17−Z004−01A−01W−0746−08 TCGA−05−5428−01A−01D−1625−08 24617 24581 24486 24256 24238 24177 21472 TCGA−05−4382−01A−01D−1265−08 TCGA−91−6836−01A−21D−1855−08 TCGA−73−4659−01A−01D−1265−08 TCGA−64−5775−01A−01D−1625−08 TCGA−17−Z062−01A−01W−0747−08 TCGA−67−6215−01A−11D−1753−08 TCGA−49−4510−01A−01D−1265−08 TCGA−49−4486−01A−01D−1265−08 TCGA−05−4390−01A−02D−1753−08 TCGA−64−5774−01A−01D−1625−08 TCGA−55−6642−01A−11D−1855−08 TCGA−55−1595−01A−01D−0969−08 TCGA−49−4507−01A−01D−1265−08 TCGA−17−Z017−01A−01W−0746−08 TCGA−17−Z016−01A−01W−0746−08 TCGA−17−Z014−01A−01W−0746−08 TCGA−05−4417−01A−22D−1855−08 TCGA−05−4244−01A−01D−1105−08 27207 27180 24694 24687 24680 24662 24621 24605 24293 24278 24276 21462 21451

TCGA−17−Z058−01A−01W−0747−08 TCGA−05−4390−01A−02D−1753−08 TCGA−17−Z061−01A−01W−0747−08 TCGA−44−2656−01 TCGA−38−4632−01A−01D−1753−08 TCGA−50−5066−01A−01D−1625−08 TCGA−50−5932−01A−11D−1753−08 TCGA−17−Z028−01A−01W−0746−08 TCGA−55−1596−01 TCGA−17−Z045−01A−01W−0746−08 TCGA−17−Z049−01A−01W−0746−08 TCGA−64−5778−01A−01D−1625−08 TCGA−17−Z033−01A−01W−0746−08 TCGA−49−4494−01A−01D−1265−08 TCGA−55−6642−01A−11D−1855−08 TCGA−64−5779−01A−01D−1625−08 TCGA−44−6778−01A−11D−1855−08 TCGA−67−4679−01B−01D−1753−08 TCGA−05−4249−01A−01D−1105−08 TCGA−50−6590−01A−12D−1855−08 TCGA−05−4395−01A−01D−1265−08 TCGA−73−4668−01A−01D−1265−08 TCGA−44−6777−01A−11D−1855−08 TCGA−50−6591−01A−11D−1753−08 TCGA−05−4384−01A−01D−1753−08 TCGA−55−1592−01 TCGA−05−5715−01A−01D−1625−08 TCGA−17−Z003−01A−01W−0746−08 TCGA−44−6147−01A−11D−1753−08 TCGA−17−Z062−01A−01W−0747−08 TCGA−50−5941−01A−11D−1753−08 TCGA−50−5051−01A−21D−1855−08 TCGA−49−6742−01A−11D−1855−08 TCGA−05−4405−01A−21D−1855−08 TCGA−75−5122−01A−01D−1753−08 TCGA−73−4658−01A−01D−1753−08 TCGA−44−2659−01 TCGA−38−4628−01A−01D−1265−08 TCGA−73−4677−01A−01D−1265−08 TCGA−73−4666−01A−01D−1265−08 TCGA−49−4487−01A−21D−1855−08 TCGA−17−Z012−01A−01W−0746−08 TCGA−91−6828−01A−11D−1855−08 TCGA−73−4670−01A−01D−1265−08 TCGA−64−1680−01 TCGA−55−6543−01A−11D−1753−08 TCGA−44−2662−01 TCGA−64−1678−01A−01W−0928−08 TCGA−44−6145−01A−11D−1753−08 TCGA−17−Z021−01A−01W−0746−08 TCGA−38−4629−01A−02D−1265−08 TCGA−17−Z000−01A−01W−0746−08 TCGA−80−5611−01A−01D−1625−08 TCGA−50−6593−01A−11D−1753−08 TCGA−44−3396−01A−01D−1265−08 TCGA−17−Z042−01A−01W−0746−08 24625 TCGA−49−4514−01A−21D−1855−08 TCGA−38−4631−01A−01D−1753−08 TCGA−75−5146−01A−01D−1625−08 TCGA−55−1594−01 TCGA−05−4432−01A−01D−1265−08 TCGA−05−4418−01A−01D−1265−08 TCGA−17−Z015−01A−01W−0746−08 TCGA−91−6829−01A−21D−1855−08 TCGA−44−2668−01 TCGA−44−6779−01A−11D−1855−08 TCGA−17−Z043−01A−01W−0746−08 TCGA−17−Z023−01A−01W−0746−08 TCGA−05−4402−01A−01D−1265−08 27201 TCGA−05−4382−01A−01D−1265−08 TCGA−05−4410−01A−21D−1855−08 TCGA−67−3771−01 TCGA−73−4676−01A−01D−1753−08 TCGA−64−5781−01A−01D−1625−08 TCGA−44−6774−01A−21D−1855−08 TCGA−44−2657−01A−01D−1105−08 TCGA−17−Z032−01A−01W−0746−08 TCGA−17−Z014−01A−01W−0746−08 TCGA−75−6206−01A−11D−1753−08 TCGA−64−1676−01 TCGA−55−5899−01A−11D−1625−08 TCGA−50−6592−01A−11D−1753−08 TCGA−44−3398−01A−01D−1105−08 TCGA−44−2666−01 TCGA−17−Z046−01A−01W−0746−08 TCGA−17−Z022−01A−01W−0746−08 TCGA−49−6767−01A−11D−1855−08 TCGA−35−5375−01A−01D−1625−08 TCGA−35−3621−01A−01D−0969−08 TCGA−05−4424−01A−22D−1855−08 TCGA−05−4397−01A−01D−1265−08 TCGA−75−5126−01A−01D−1753−08 TCGA−64−1677−01A−01W−0928−08 TCGA−50−5049−01A−01D−1625−08 TCGA−49−6743−01A−11D−1855−08 TCGA−38−4625−01A−01D−1553−08 TCGA−17−Z057−01A−01W−0747−08 TCGA−17−Z053−01A−01W−0747−08 TCGA−17−Z026−01A−01W−0746−08 TCGA−17−Z010−01A−01W−0746−08 TCGA−91−6836−01A−21D−1855−08 TCGA−50−5933−01A−11D−1753−08 TCGA−50−5072−01A−21D−1855−08 TCGA−50−5044−01A−21D−1855−08 TCGA−44−2655−01 TCGA−17−Z060−01A−01W−0747−08 TCGA−17−Z008−01A−01W−0746−08 TCGA−05−4427−01A−21D−1855−08 TCGA−05−4398−01A−01D−1265−08 TCGA−75−5125−01A−01D−1753−08 TCGA−55−6712−01A−11D−1855−08 TCGA−50−6594−01A−11D−1753−08 TCGA−49−6745−01A−11D−1855−08 TCGA−44−6144−01A−11D−1753−08 TCGA−44−3918−01A−01D−1105−08 TCGA−17−Z052−01A−01W−0747−08 TCGA−17−Z037−01A−01W−0746−08 TCGA−17−Z025−01A−01W−0746−08 TCGA−17−Z016−01A−01W−0746−08 TCGA−17−Z005−01A−01W−0746−08 TCGA−17−Z001−01A−01W−0746−08 TCGA−05−4403−01A−01D−1265−08

Presynaptic Phase Of Homologous DNA Pairing And Strand Exchange FDR = 0.13%, FDR nod = 0.23% P73 Transcription Factor Network FDR = 0.11%, FDR nod = 1.2%

BARD1 ATR

BRCA2

WRN

MRE11A

BLM

CHEK1

RAD17

RAD51C

RFC2

TOPBP1

EXO1

NBN

RAD50

RAD51

RAD51D

RBBP8

HUS1

RAD1

RAD51B

RAD9A

RFC3

RFC5

RHNO1

RPA2 unknown CG mut

DNA2

RB1 NTRK1 BRCA2 CLCA2 TP63 WT1 CASP2 JAG2 PRKACB AFP CHEK1 JAK1 RNF43 SERPINE1 ABL1 CCNE1 GATA1 ITCH NDUFS2 PML BAX CCNA2 FOXO3 IL4R MDM2 MYC UBE4B ADA AEN BUB1 CCNB1 CDK1 DCP1B FAS FLOT2 GDF15 HAGH MAPK11 PLK3 RACK1 RAD51 TP73 BCL2L11 BIN1 BUB3 CDK6 CDKN1A DEDD EP300 FASN GRAMD4 HEY2 IL1RAP MAPK14 NEDD4L PEA15 PFDN5 PLK1 RCHY1 RELA SERPINA1 SIRT1 TP53I3 TUBA1A WWOX

BRIP1

unknown CG mut

unknown CG mut

ATRIP

wt TOP3A wt

known HCG mut BRCA1

known HCG mut

known HCG mut

SYNE1 SYNE2 ATR DIDO1 BRCA1 POT1 STAG3 HIST2H2AC SUN1 SYCP1 SMC1B HIST1H2BC HIST1H2BJ HIST1H4I HIST2H2BE RAD21 SMC3 ACD FKBP6 HIST1H2AB HIST1H2AC HIST1H2AJ HIST1H2BH HIST1H4E HIST1H4H HIST1H4J HIST3H2BB HSPA2 STAG2 SYCP2 SYCP3 H2AFX HIST1H2AE HIST1H2BF HIST1H2BI HIST1H2BL HIST1H2BN HIST1H4B HIST1H4D HIST1H4L LMNB1 REC8 SMC1A STAG1 SUN2 SYCE1 SYCE2 TERF1 TINF2 UBE2I

ATM

wt wt

unknown CG mut

known HCG mut

ATM PRKDC HERC2 RIF1 MDC1 BRCA1 TDP1 WHSC1 XRCC5 BARD1 MRE11A BRE FAM175A HIST1H2BJ HIST3H2BB LIG4 RAD50 BRCC3 HIST1H2BC HIST1H2BF HIST1H4D HIST1H4E HIST1H4J HIST2H2BE PAXIP1 POLL POLM RNF168 SUMO1 TDP2 TP53BP1 UIMC1 DCLRE1C H2AFX HIST1H2BH HIST1H2BI HIST1H2BL HIST1H2BN HIST1H4B HIST1H4H HIST1H4I HIST1H4L NBN NHEJ1 RNF8 UBE2N UBE2V2 XRCC4 XRCC6 TCGA−44−6776−01A−11D−1855−08 TCGA−44−2665−01 TCGA−38−4631−01A−01D−1753−08 TCGA−80−5611−01A−01D−1625−08 TCGA−67−3774−01 24234 TCGA−44−4112−01 TCGA−05−5429−01A−01D−1625−08 TCGA−49−6745−01A−11D−1855−08 27192 TCGA−75−5126−01A−01D−1753−08 TCGA−73−4668−01A−01D−1265−08 24267 24193 TCGA−50−5072−01A−21D−1855−08 TCGA−73−4662−01A−01D−1265−08 TCGA−73−4677−01A−01D−1265−08 TCGA−67−4679−01B−01D−1753−08 TCGA−17−Z060−01A−01W−0747−08 TCGA−17−Z010−01A−01W−0746−08 TCGA−91−6835−01A−11D−1855−08 TCGA−17−Z051−01A−01W−0747−08 TCGA−05−4415−01A−22D−1855−08 TCGA−67−3773−01 TCGA−17−Z036−01A−01W−0746−08 TCGA−17−Z033−01A−01W−0746−08 TCGA−50−5936−01A−11D−1625−08 TCGA−49−6744−01A−11D−1855−08 TCGA−49−4506−01A−01D−1265−08 TCGA−05−4250−01A−01D−1105−08 TCGA−64−5779−01A−01D−1625−08 TCGA−50−5044−01A−21D−1855−08 TCGA−91−6828−01A−11D−1855−08 TCGA−64−5815−01A−01D−1625−08 TCGA−05−4418−01A−01D−1265−08 24218 TCGA−44−3398−01A−01D−1105−08 TCGA−73−4658−01A−01D−1753−08 TCGA−17−Z032−01A−01W−0746−08 24609 24261 TCGA−49−4507−01A−01D−1265−08 TCGA−05−4417−01A−22D−1855−08 24276 21462 TCGA−73−4659−01A−01D−1265−08 TCGA−67−6215−01A−11D−1753−08 TCGA−64−5774−01A−01D−1625−08 TCGA−55−6642−01A−11D−1855−08 TCGA−55−1595−01A−01D−0969−08 TCGA−49−4510−01A−01D−1265−08 TCGA−49−4486−01A−01D−1265−08 TCGA−17−Z016−01A−01W−0746−08 TCGA−17−Z014−01A−01W−0746−08 TCGA−05−4390−01A−02D−1753−08 TCGA−05−4244−01A−01D−1105−08 27207 27180 24694 24687 24680 24662 24605 24293 24278 21451 TCGA−17−Z026−01A−01W−0746−08 TCGA−17−Z022−01A−01W−0746−08 TCGA−91−6829−01A−21D−1855−08 TCGA−17−Z049−01A−01W−0746−08 TCGA−05−4427−01A−21D−1855−08 TCGA−05−4397−01A−01D−1265−08 TCGA−05−4382−01A−01D−1265−08 TCGA−64−5775−01A−01D−1625−08 TCGA−50−6593−01A−11D−1753−08 TCGA−50−6590−01A−12D−1855−08 TCGA−44−6775−01A−11D−1855−08 TCGA−44−3396−01A−01D−1265−08 TCGA−38−4625−01A−01D−1553−08 TCGA−35−4122−01A−01D−1105−08 TCGA−17−Z062−01A−01W−0747−08 TCGA−17−Z056−01A−01W−0747−08 TCGA−17−Z042−01A−01W−0746−08 TCGA−17−Z015−01A−01W−0746−08 TCGA−05−4424−01A−22D−1855−08 TCGA−05−4410−01A−21D−1855−08 27173 24177 21472 21438 TCGA−91−6836−01A−21D−1855−08 TCGA−67−3771−01 TCGA−64−1678−01A−01W−0928−08 TCGA−64−1677−01A−01W−0928−08 TCGA−55−1594−01 TCGA−50−5931−01A−11D−1753−08 TCGA−50−5049−01A−01D−1625−08 TCGA−50−5045−01A−01D−1625−08 TCGA−49−4514−01A−21D−1855−08 TCGA−44−6779−01A−11D−1855−08 TCGA−44−6777−01A−11D−1855−08 TCGA−44−6774−01A−21D−1855−08 TCGA−44−6144−01A−11D−1753−08 TCGA−44−2668−01 TCGA−44−2662−01 TCGA−38−4632−01A−01D−1753−08 TCGA−35−5375−01A−01D−1625−08 TCGA−35−4123−01A−01D−1105−08 TCGA−35−3621−01A−01D−0969−08 TCGA−17−Z061−01A−01W−0747−08 TCGA−17−Z057−01A−01W−0747−08 TCGA−17−Z055−01A−01W−0747−08 TCGA−17−Z053−01A−01W−0747−08 TCGA−17−Z045−01A−01W−0746−08 TCGA−17−Z043−01A−01W−0746−08 TCGA−17−Z023−01A−01W−0746−08 TCGA−17−Z017−01A−01W−0746−08 TCGA−17−Z005−01A−01W−0746−08 TCGA−17−Z003−01A−01W−0746−08 TCGA−05−4432−01A−01D−1265−08 TCGA−05−4420−01A−01D−1265−08 TCGA−05−4402−01A−01D−1265−08 TCGA−05−4398−01A−01D−1265−08 TCGA−05−4395−01A−01D−1265−08 27210 27201 27182 24625 24621 24598 24468 24331 24317 24239 21468 TCGA−91−6831−01A−11D−1855−08 TCGA−75−6211−01A−11D−1753−08 TCGA−75−6207−01A−11D−1753−08 TCGA−75−5147−01A−01D−1625−08 TCGA−75−5146−01A−01D−1625−08 TCGA−75−5125−01A−01D−1753−08 TCGA−73−4676−01A−01D−1753−08 TCGA−73−4670−01A−01D−1265−08 TCGA−73−4666−01A−01D−1265−08 TCGA−67−3770−01 TCGA−64−5778−01A−01D−1625−08 TCGA−64−1676−01 TCGA−55−6712−01A−11D−1855−08 TCGA−55−5899−01A−11D−1625−08 TCGA−55−1596−01 TCGA−55−1592−01 TCGA−50−6595−01A−12D−1855−08 TCGA−50−6594−01A−11D−1753−08 TCGA−50−6592−01A−11D−1753−08 TCGA−50−6591−01A−11D−1753−08 TCGA−50−5946−01A−11D−1753−08 TCGA−50−5944−01A−11D−1753−08 TCGA−50−5941−01A−11D−1753−08 TCGA−50−5939−01A−11D−1625−08 TCGA−50−5933−01A−11D−1753−08 TCGA−50−5068−01A−01D−1625−08 TCGA−50−5066−01A−01D−1625−08 TCGA−49−6767−01A−11D−1855−08 TCGA−49−4505−01A−01D−1265−08 TCGA−49−4490−01A−21D−1855−08 TCGA−49−4487−01A−21D−1855−08 TCGA−44−6778−01A−11D−1855−08 TCGA−44−6147−01A−11D−1753−08 TCGA−44−6145−01A−11D−1753−08 TCGA−44−5645−01A−01D−1625−08 TCGA−44−5643−01A−01D−1625−08 TCGA−44−3918−01A−01D−1105−08 TCGA−44−2666−01 TCGA−44−2659−01 TCGA−44−2656−01 TCGA−38−6178−01A−11D−1753−08 TCGA−38−4630−01A−01D−1265−08 TCGA−38−4629−01A−02D−1265−08 TCGA−17−Z052−01A−01W−0747−08 TCGA−17−Z047−01A−01W−0747−08 TCGA−17−Z046−01A−01W−0746−08 TCGA−17−Z044−01A−01W−0746−08 TCGA−17−Z037−01A−01W−0746−08 TCGA−17−Z035−01A−01W−0746−08 TCGA−17−Z030−01A−01W−0746−08 TCGA−17−Z028−01A−01W−0746−08 TCGA−17−Z027−01A−01W−0746−08 TCGA−17−Z021−01A−01W−0746−08 TCGA−17−Z020−01A−01W−0746−08 TCGA−17−Z012−01A−01W−0746−08 TCGA−17−Z007−01A−01W−0746−08 TCGA−17−Z001−01A−01W−0746−08 TCGA−05−5428−01A−01D−1625−08 TCGA−05−5423−01A−01D−1625−08 TCGA−05−4433−01A−22D−1855−08 TCGA−05−4430−01A−02D−1265−08 TCGA−05−4426−01A−01D−1265−08 TCGA−05−4405−01A−21D−1855−08 TCGA−05−4384−01A−01D−1753−08 27224 27206 27197 27193 27188 27185 27178 27175 24693 24689 24682 24681 24678 24669 24667 24665 24663 24656 24653 24633 24623 24617 24607 24600 24599 24597 24486 24320 24319 24312 24302 24301 24295 24292 24291 24289 24279 24270 24269 24256 24252 24250 24245 24238 24205 21454 21452 21442

Nonhomologous End Joining (NHEJ) FDR = 0.35%, FDR nod = 0.23% Meiotic Synapsis FDR = 5.3%, FDR nod = 1.4%

wt wt

unknown CG mut


TEX15 ATM PRDM9 BRCA2 BLM BRCA1 MSH4 HIST2H2AC MRE11A H3F3B HIST1H4I TOP3A HIST1H2AB HIST1H2AC HIST1H2AJ HIST1H2BC HIST1H2BF HIST1H2BH HIST1H2BJ HIST1H3F HIST1H3G HIST1H3J HIST1H4D HIST1H4E HIST1H4J MLH1 MND1 MSH5 RAD50 RAD51 CDK4 DMC1 H2AFX HIST1H2AE HIST1H2BI HIST1H2BL HIST1H2BN HIST1H3A HIST1H3B HIST1H3D HIST1H3E HIST1H3H HIST1H4B HIST1H4H HIST1H4L HIST2H2BE HIST2H3D HIST3H2BB MLH3 NBN PSMC3IP RAD51C RBBP8 RPA2 SPO11 unknown CG mut TP53 ATM PTEN MSH6 BLM MAP3K5 MMP1 RB1 ATR E2F1 JAK1 MDM2 MSH2 SMAD2 STAT1 BAX BCL2 BRCA1 CASP3 CASP8 AKT1 CASP9 CDK1 CDK4 CDKN1A CDKN1B CDKN2B CHEK1 CHEK2 MRE11A NOXA1 POU2F1 RAD50 SMAD3

TCGA−17−Z013−01A−01W−0746−08 TCGA−50−5066−01A−01D−1625−08 TCGA−73−4666−01A−01D−1265−08 TCGA−17−Z020−01A−01W−0746−08 TCGA−17−Z056−01A−01W−0747−08 TCGA−64−1678−01A−01W−0928−08 TCGA−38−4626−01A−01D−1553−08 TCGA−50−6594−01A−11D−1753−08 TCGA−05−4403−01A−01D−1265−08 TCGA−73−4670−01A−01D−1265−08 TCGA−17−Z003−01A−01W−0746−08 TCGA−44−6777−01A−11D−1855−08 TCGA−05−4405−01A−21D−1855−08 TCGA−49−6767−01A−11D−1855−08 TCGA−38−4632−01A−01D−1753−08 TCGA−49−4487−01A−21D−1855−08 TCGA−44−6147−01A−11D−1753−08 TCGA−05−4425−01A−01D−1753−08 TCGA−44−2656−01 TCGA−50−6597−01A−11D−1855−08 TCGA−05−4415−01A−22D−1855−08 TCGA−64−5781−01A−01D−1625−08 TCGA−50−5072−01A−21D−1855−08 TCGA−49−4494−01A−01D−1265−08 TCGA−55−1592−01 TCGA−44−6145−01A−11D−1753−08 TCGA−38−4630−01A−01D−1265−08 TCGA−38−4625−01A−01D−1553−08 TCGA−44−6776−01A−11D−1855−08 TCGA−44−6774−01A−21D−1855−08 TCGA−05−4432−01A−01D−1265−08 27173 TCGA−50−5044−01A−21D−1855−08 TCGA−44−6775−01A−11D−1855−08 TCGA−64−5779−01A−01D−1625−08 TCGA−05−4250−01A−01D−1105−08 TCGA−17−Z055−01A−01W−0747−08 TCGA−50−5045−01A−01D−1625−08 TCGA−44−3398−01A−01D−1105−08 TCGA−17−Z049−01A−01W−0746−08 TCGA−17−Z045−01A−01W−0746−08 TCGA−50−5049−01A−01D−1625−08 TCGA−75−5126−01A−01D−1753−08 TCGA−49−6742−01A−11D−1855−08 TCGA−17−Z030−01A−01W−0746−08 24298 TCGA−17−Z026−01A−01W−0746−08 TCGA−80−5611−01A−01D−1625−08 TCGA−50−6593−01A−11D−1753−08 TCGA−44−3396−01A−01D−1265−08 TCGA−17−Z042−01A−01W−0746−08 24625 TCGA−05−4410−01A−21D−1855−08 TCGA−17−Z046−01A−01W−0746−08 TCGA−73−4658−01A−01D−1753−08 TCGA−44−2665−01 TCGA−44−2661−01A−01D−1105−08 TCGA−05−4418−01A−01D−1265−08 TCGA−05−4389−01A−01D−1265−08 TCGA−35−3621−01A−01D−0969−08 TCGA−05−4427−01A−21D−1855−08 TCGA−38−4631−01A−01D−1753−08 24181 TCGA−75−6211−01A−11D−1753−08 TCGA−73−4662−01A−01D−1265−08 TCGA−44−3919−01 TCGA−17−Z057−01A−01W−0747−08 TCGA−17−Z025−01A−01W−0746−08 TCGA−05−4397−01A−01D−1265−08 27206 TCGA−17−Z023−01A−01W−0746−08 TCGA−17−Z022−01A−01W−0746−08 TCGA−05−4398−01A−01D−1265−08 TCGA−64−1677−01A−01W−0928−08 TCGA−05−4424−01A−22D−1855−08 TCGA−91−6829−01A−21D−1855−08 TCGA−44−6779−01A−11D−1855−08 TCGA−44−2668−01 TCGA−17−Z060−01A−01W−0747−08 TCGA−17−Z043−01A−01W−0746−08 TCGA−17−Z015−01A−01W−0746−08 TCGA−17−Z010−01A−01W−0746−08 TCGA−05−4402−01A−01D−1265−08 27201 TCGA−05−4382−01A−01D−1265−08 TCGA−64−5775−01A−01D−1625−08 TCGA−55−1595−01A−01D−0969−08 TCGA−49−4486−01A−01D−1265−08 TCGA−05−4390−01A−02D−1753−08 TCGA−05−4244−01A−01D−1105−08 TCGA−91−6836−01A−21D−1855−08 TCGA−73−4659−01A−01D−1265−08 TCGA−67−6215−01A−11D−1753−08 TCGA−64−5774−01A−01D−1625−08 TCGA−55−6642−01A−11D−1855−08 TCGA−49−4510−01A−01D−1265−08 TCGA−49−4507−01A−01D−1265−08 TCGA−17−Z062−01A−01W−0747−08 TCGA−17−Z017−01A−01W−0746−08 TCGA−17−Z016−01A−01W−0746−08 TCGA−17−Z014−01A−01W−0746−08 TCGA−05−4417−01A−22D−1855−08 27207 27180 24694 24687 24680 24662 24621 24605 24293 24278 24276 21462 21451

TCGA−05−4389−01A−01D−1265−08 TCGA−64−1680−01 TCGA−17−Z020−01A−01W−0746−08 TCGA−80−5611−01A−01D−1625−08 TCGA−17−Z027−01A−01W−0746−08 TCGA−50−6594−01A−11D−1753−08 TCGA−17−Z028−01A−01W−0746−08 TCGA−05−4244−01A−01D−1105−08 TCGA−50−6590−01A−12D−1855−08 TCGA−44−6145−01A−11D−1753−08 TCGA−49−6744−01A−11D−1855−08 TCGA−05−4395−01A−01D−1265−08 TCGA−67−6217−01A−11D−1753−08 TCGA−38−4626−01A−01D−1553−08 TCGA−55−1596−01 TCGA−91−6831−01A−11D−1855−08 TCGA−38−4632−01A−01D−1753−08 TCGA−17−Z013−01A−01W−0746−08 24667 24600 24267 24193 TCGA−05−5428−01A−01D−1625−08 TCGA−44−4112−01 TCGA−17−Z058−01A−01W−0747−08 24256 TCGA−38−4630−01A−01D−1265−08 TCGA−05−4426−01A−01D−1265−08 TCGA−44−2662−01 24234 TCGA−50−5049−01A−01D−1625−08 TCGA−49−4514−01A−21D−1855−08 TCGA−35−4122−01A−01D−1105−08 TCGA−91−6836−01A−21D−1855−08 TCGA−49−4510−01A−01D−1265−08 TCGA−17−Z040−01A−01W−0746−08 TCGA−73−4668−01A−01D−1265−08 TCGA−50−5044−01A−21D−1855−08 TCGA−35−4123−01A−01D−1105−08 TCGA−17−Z032−01A−01W−0746−08 27224 24296 TCGA−64−5774−01A−01D−1625−08 TCGA−05−5420−01A−01D−1625−08 27235 TCGA−67−4679−01B−01D−1753−08 24223 21461 TCGA−17−Z053−01A−01W−0747−08 TCGA−17−Z012−01A−01W−0746−08 TCGA−05−4405−01A−21D−1855−08 TCGA−05−4249−01A−01D−1105−08 TCGA−73−4658−01A−01D−1753−08 TCGA−38−4629−01A−02D−1265−08 TCGA−17−Z041−01A−01W−0746−08 TCGA−05−5429−01A−01D−1625−08 TCGA−38−4625−01A−01D−1553−08 TCGA−50−5072−01A−21D−1855−08 TCGA−17−Z015−01A−01W−0746−08 24177 TCGA−44−6774−01A−21D−1855−08 TCGA−44−6776−01A−11D−1855−08 TCGA−05−4432−01A−01D−1265−08 27173 TCGA−64−1678−01A−01W−0928−08 TCGA−49−6742−01A−11D−1855−08 TCGA−17−Z018−01A−01W−0746−08 TCGA−05−4390−01A−02D−1753−08 TCGA−50−5933−01A−11D−1753−08 TCGA−49−4488−01A−01D−1753−08 TCGA−17−Z043−01A−01W−0746−08 24617 24295 24653 TCGA−64−5815−01A−01D−1625−08 TCGA−44−6779−01A−11D−1855−08 24291 24250 TCGA−44−3918−01A−01D−1105−08 TCGA−05−4420−01A−01D−1265−08 TCGA−73−4666−01A−01D−1265−08 TCGA−17−Z014−01A−01W−0746−08 TCGA−05−5423−01A−01D−1625−08 TCGA−64−5781−01A−01D−1625−08 TCGA−17−Z030−01A−01W−0746−08 TCGA−49−4487−01A−21D−1855−08 27180 TCGA−64−5775−01A−01D−1625−08 TCGA−55−1592−01 TCGA−49−4505−01A−01D−1265−08 TCGA−17−Z026−01A−01W−0746−08 TCGA−44−6777−01A−11D−1855−08 TCGA−05−4410−01A−21D−1855−08 21442 27223 24666 24245 TCGA−67−3771−01 TCGA−50−5941−01A−11D−1753−08 TCGA−05−4418−01A−01D−1265−08 TCGA−75−5126−01A−01D−1753−08 TCGA−49−4490−01A−21D−1855−08 TCGA−44−3398−01A−01D−1105−08 TCGA−73−4670−01A−01D−1265−08 TCGA−17−Z056−01A−01W−0747−08 TCGA−17−Z003−01A−01W−0746−08 TCGA−05−4427−01A−21D−1855−08 TCGA−17−Z022−01A−01W−0746−08 TCGA−73−4662−01A−01D−1265−08 TCGA−35−3621−01A−01D−0969−08 TCGA−17−Z025−01A−01W−0746−08 TCGA−17−Z023−01A−01W−0746−08 TCGA−05−4382−01A−01D−1265−08 24181 TCGA−75−6211−01A−11D−1753−08 TCGA−49−4486−01A−01D−1265−08 TCGA−44−3919−01 TCGA−38−4631−01A−01D−1753−08 27206 TCGA−17−Z062−01A−01W−0747−08 TCGA−05−4398−01A−01D−1265−08 21468 TCGA−73−4659−01A−01D−1265−08 TCGA−67−3770−01 TCGA−49−6743−01A−11D−1855−08 TCGA−49−4494−01A−01D−1265−08 TCGA−17−Z060−01A−01W−0747−08 TCGA−17−Z008−01A−01W−0746−08 TCGA−05−4424−01A−22D−1855−08 24662 24625 24582 24481 24268 TCGA−05−4397−01A−01D−1265−08 TCGA−17−Z049−01A−01W−0746−08 21472 TCGA−91−6829−01A−21D−1855−08 TCGA−91−6828−01A−11D−1855−08 TCGA−44−6775−01A−11D−1855−08 TCGA−35−5375−01A−01D−1625−08 TCGA−17−Z057−01A−01W−0747−08 TCGA−91−6835−01A−11D−1855−08 TCGA−17−Z061−01A−01W−0747−08 TCGA−17−Z051−01A−01W−0747−08 TCGA−17−Z042−01A−01W−0746−08 TCGA−05−4415−01A−22D−1855−08 27210 24331 24276 24239 21462 21438

PDGF Receptor Signaling Network FDR = 0.02%, FDR nod = 0.081% Regulation Of TP53 Activity Through Phosphorylation FDR = 2e−12%, FDR nod = 1.1%

TCGA−17−Z022−01A−01W−0746−08 TCGA−75−5126−01A−01D−1753−08 TCGA−05−4384−01A−01D−1753−08 TCGA−05−4410−01A−21D−1855−08 TCGA−50−5936−01A−11D−1625−08 TCGA−44−2656−01 TCGA−05−4389−01A−01D−1265−08 TCGA−91−6829−01A−21D−1855−08 TCGA−44−2666−01 TCGA−44−2662−01 TCGA−17−Z046−01A−01W−0746−08 TCGA−05−4422−01A−01D−1265−08 TCGA−05−4390−01A−02D−1753−08 24605 24320 TCGA−05−4397−01A−01D−1265−08 21472 TCGA−75−5125−01A−01D−1753−08 TCGA−67−3770−01 TCGA−55−6712−01A−11D−1855−08 TCGA−50−5066−01A−01D−1625−08 TCGA−49−6767−01A−11D−1855−08 TCGA−44−4112−01 TCGA−44−2668−01 TCGA−38−4632−01A−01D−1753−08 TCGA−35−3621−01A−01D−0969−08 TCGA−17−Z028−01A−01W−0746−08 TCGA−17−Z023−01A−01W−0746−08 TCGA−17−Z014−01A−01W−0746−08 TCGA−17−Z003−01A−01W−0746−08 TCGA−05−4382−01A−01D−1265−08 24617 24599 24276 24181 21442

TCGA−05−5420−01A−01D−1625−08 TCGA−05−4403−01A−01D−1265−08 TCGA−49−4506−01A−01D−1265−08 TCGA−05−5715−01A−01D−1625−08 TCGA−44−2657−01A−01D−1105−08 TCGA−17−Z013−01A−01W−0746−08 TCGA−64−5815−01A−01D−1625−08 TCGA−73−4662−01A−01D−1265−08 TCGA−49−4488−01A−01D−1753−08 TCGA−75−6206−01A−11D−1753−08 TCGA−44−4112−01 TCGA−38−4626−01A−01D−1553−08 TCGA−05−4425−01A−01D−1753−08 TCGA−50−6597−01A−11D−1855−08 TCGA−80−5611−01A−01D−1625−08 TCGA−17−Z060−01A−01W−0747−08 TCGA−44−3398−01A−01D−1105−08 TCGA−44−2655−01 TCGA−67−3773−01 TCGA−67−3772−01A−01W−0928−08 24267 24193 TCGA−49−4494−01A−01D−1265−08 TCGA−64−5781−01A−01D−1625−08 TCGA−50−5044−01A−21D−1855−08 TCGA−64−5779−01A−01D−1625−08 TCGA−05−4250−01A−01D−1105−08 TCGA−17−Z010−01A−01W−0746−08 TCGA−71−6725−01A−11D−1855−08 TCGA−17−Z033−01A−01W−0746−08 TCGA−17−Z018−01A−01W−0746−08 TCGA−75−5126−01A−01D−1753−08 TCGA−49−6742−01A−11D−1855−08 24298 24181 TCGA−73−4658−01A−01D−1753−08 TCGA−38−4631−01A−01D−1753−08 TCGA−05−4389−01A−01D−1265−08 TCGA−44−2665−01 TCGA−44−2661−01A−01D−1105−08 TCGA−05−4418−01A−01D−1265−08 TCGA−55−1595−01A−01D−0969−08 TCGA−17−Z016−01A−01W−0746−08 TCGA−05−4390−01A−02D−1753−08 TCGA−05−4244−01A−01D−1105−08 TCGA−73−4659−01A−01D−1265−08 TCGA−67−6215−01A−11D−1753−08 TCGA−64−5774−01A−01D−1625−08 TCGA−55−6642−01A−11D−1855−08 TCGA−49−4510−01A−01D−1265−08 TCGA−17−Z014−01A−01W−0746−08 27180 24687 24680 24662 24605 24293 24276 21462 21451 TCGA−05−4417−01A−22D−1855−08 TCGA−05−4415−01A−22D−1855−08 TCGA−50−5072−01A−21D−1855−08 TCGA−49−4507−01A−01D−1265−08 TCGA−49−4486−01A−01D−1265−08 TCGA−44−6776−01A−11D−1855−08 27207 24694 24278 TCGA−73−4677−01A−01D−1265−08 TCGA−67−3774−01 TCGA−50−5932−01A−11D−1753−08 TCGA−35−3615−01 TCGA−05−4422−01A−01D−1265−08 27232 27229 27223 27190 27174 24691 24683 24666 24613 24318 24303 24280 24249 24213 24212 24187 21456 21446 21436 TCGA−17−Z022−01A−01W−0746−08 TCGA−17−Z026−01A−01W−0746−08 TCGA−05−4382−01A−01D−1265−08 TCGA−50−5049−01A−01D−1625−08 TCGA−44−2668−01 TCGA−17−Z046−01A−01W−0746−08 TCGA−05−4410−01A−21D−1855−08 TCGA−91−6836−01A−21D−1855−08 TCGA−55−1592−01 TCGA−05−4424−01A−22D−1855−08 TCGA−64−5775−01A−01D−1625−08 TCGA−55−1596−01 TCGA−50−6594−01A−11D−1753−08 TCGA−50−6590−01A−12D−1855−08 TCGA−49−6767−01A−11D−1855−08 TCGA−44−6777−01A−11D−1855−08 TCGA−44−6775−01A−11D−1855−08 TCGA−44−6774−01A−21D−1855−08 TCGA−44−2656−01 TCGA−35−3621−01A−01D−0969−08 TCGA−17−Z055−01A−01W−0747−08 TCGA−17−Z023−01A−01W−0746−08 TCGA−05−4432−01A−01D−1265−08 TCGA−05−4398−01A−01D−1265−08 TCGA−73−4670−01A−01D−1265−08 TCGA−64−5778−01A−01D−1625−08 TCGA−64−1678−01A−01W−0928−08 TCGA−64−1677−01A−01W−0928−08 TCGA−50−6593−01A−11D−1753−08 TCGA−50−5066−01A−01D−1625−08 TCGA−49−4487−01A−21D−1855−08 TCGA−44−6779−01A−11D−1855−08 TCGA−44−6145−01A−11D−1753−08 TCGA−44−6144−01A−11D−1753−08 TCGA−44−3396−01A−01D−1265−08 TCGA−38−4630−01A−01D−1265−08 TCGA−35−4122−01A−01D−1105−08 TCGA−17−Z062−01A−01W−0747−08 TCGA−17−Z056−01A−01W−0747−08 TCGA−17−Z045−01A−01W−0746−08 TCGA−17−Z042−01A−01W−0746−08 TCGA−17−Z017−01A−01W−0746−08 TCGA−17−Z015−01A−01W−0746−08 TCGA−05−4427−01A−21D−1855−08 TCGA−05−4402−01A−01D−1265−08 27210 27173 TCGA−91−6831−01A−11D−1855−08 TCGA−91−6829−01A−21D−1855−08 TCGA−75−5146−01A−01D−1625−08 TCGA−73−4666−01A−01D−1265−08 TCGA−67−3771−01 TCGA−67−3770−01 TCGA−50−5939−01A−11D−1625−08 TCGA−50−5933−01A−11D−1753−08 TCGA−50−5045−01A−01D−1625−08 TCGA−49−4514−01A−21D−1855−08 TCGA−49−4505−01A−01D−1265−08 TCGA−44−6147−01A−11D−1753−08 TCGA−44−5643−01A−01D−1625−08 TCGA−44−3918−01A−01D−1105−08 TCGA−44−2659−01 TCGA−38−4632−01A−01D−1753−08 TCGA−38−4629−01A−02D−1265−08 TCGA−38−4625−01A−01D−1553−08 TCGA−35−5375−01A−01D−1625−08 TCGA−17−Z057−01A−01W−0747−08 TCGA−17−Z049−01A−01W−0746−08 TCGA−17−Z043−01A−01W−0746−08 TCGA−17−Z030−01A−01W−0746−08 TCGA−17−Z027−01A−01W−0746−08 TCGA−17−Z012−01A−01W−0746−08 TCGA−17−Z003−01A−01W−0746−08 TCGA−05−5428−01A−01D−1625−08 TCGA−05−4426−01A−01D−1265−08 TCGA−05−4397−01A−01D−1265−08 TCGA−05−4395−01A−01D−1265−08 TCGA−05−4384−01A−01D−1753−08 27206 27201 27188 27185 24663 24625 24621 24607 24600 24486 24279 24270 24205 21472 21454 TCGA−75−6211−01A−11D−1753−08 TCGA−75−6207−01A−11D−1753−08 TCGA−75−5147−01A−01D−1625−08 TCGA−75−5125−01A−01D−1753−08 TCGA−73−4676−01A−01D−1753−08 TCGA−64−1676−01 TCGA−55−6712−01A−11D−1855−08 TCGA−55−5899−01A−11D−1625−08 TCGA−55−1594−01 TCGA−50−6595−01A−12D−1855−08 TCGA−50−6592−01A−11D−1753−08 TCGA−50−6591−01A−11D−1753−08 TCGA−50−5946−01A−11D−1753−08 TCGA−50−5944−01A−11D−1753−08 TCGA−50−5941−01A−11D−1753−08 TCGA−50−5931−01A−11D−1753−08 TCGA−50−5068−01A−01D−1625−08 TCGA−49−4490−01A−21D−1855−08 TCGA−44−6778−01A−11D−1855−08 TCGA−44−5645−01A−01D−1625−08 TCGA−44−2666−01 TCGA−44−2662−01 TCGA−38−6178−01A−11D−1753−08 TCGA−35−4123−01A−01D−1105−08 TCGA−17−Z061−01A−01W−0747−08 TCGA−17−Z053−01A−01W−0747−08 TCGA−17−Z052−01A−01W−0747−08 TCGA−17−Z047−01A−01W−0747−08 TCGA−17−Z044−01A−01W−0746−08 TCGA−17−Z037−01A−01W−0746−08 TCGA−17−Z035−01A−01W−0746−08 TCGA−17−Z028−01A−01W−0746−08 TCGA−17−Z021−01A−01W−0746−08 TCGA−17−Z020−01A−01W−0746−08 TCGA−17−Z007−01A−01W−0746−08 TCGA−17−Z005−01A−01W−0746−08 TCGA−17−Z001−01A−01W−0746−08 TCGA−05−5423−01A−01D−1625−08 TCGA−05−4433−01A−22D−1855−08 TCGA−05−4430−01A−02D−1265−08 TCGA−05−4420−01A−01D−1265−08 TCGA−05−4405−01A−21D−1855−08 27224 27197 27193 27182 27178 27175 24693 24689 24682 24681 24678 24669 24667 24665 24656 24653 24633 24623 24617 24599 24598 24597 24468 24331 24320 24319 24317 24312 24302 24301 24295 24292 24291 24289 24269 24256 24252 24250 24245 24239 24238 24177 21468 21452 21442 21438

PDGF Signaling Pathway (Mammal) ( PDGF Signaling Pathway ) FDR = 2e−12%, FDR nod = 5% PDGF Signaling Pathway ( PDGF Signaling Pathway ) FDR = 2e−12%, FDR nod = 2.2%

24205 TCGA−38−4625−01A−01D−1553−08 24177 TCGA−05−4432−01A−01D−1265−08 TCGA−75−5147−01A−01D−1625−08 TCGA−44−2661−01A−01D−1105−08 TCGA−05−4424−01A−22D−1855−08 TCGA−50−5049−01A−01D−1625−08 TCGA−17−Z011−01A−01W−0746−08 27177 TCGA−44−6775−01A−11D−1855−08 TCGA−05−4389−01A−01D−1265−08 TCGA−44−2656−01 TCGA−17−Z049−01A−01W−0746−08 TCGA−17−Z012−01A−01W−0746−08 TCGA−05−4420−01A−01D−1265−08 21458 TCGA−64−5781−01A−01D−1625−08 TCGA−17−Z053−01A−01W−0747−08 TCGA−17−Z015−01A−01W−0746−08 TCGA−80−5611−01A−01D−1625−08 TCGA−73−4668−01A−01D−1265−08 TCGA−44−6778−01A−11D−1855−08 TCGA−91−6829−01A−21D−1855−08 TCGA−44−2666−01 TCGA−44−2662−01 TCGA−91−6835−01A−11D−1855−08 TCGA−49−4506−01A−01D−1265−08 TCGA−38−4631−01A−01D−1753−08 TCGA−05−5423−01A−01D−1625−08 TCGA−50−6590−01A−12D−1855−08 TCGA−50−5044−01A−21D−1855−08 TCGA−44−5645−01A−01D−1625−08 TCGA−44−5643−01A−01D−1625−08 TCGA−17−Z046−01A−01W−0746−08 24320 TCGA−35−4123−01A−01D−1105−08 TCGA−17−Z018−01A−01W−0746−08 27193 24280 TCGA−49−6743−01A−11D−1855−08 TCGA−55−1592−01 TCGA−50−6592−01A−11D−1753−08 TCGA−05−4422−01A−01D−1265−08 TCGA−49−6742−01A−11D−1855−08 TCGA−05−4398−01A−01D−1265−08 TCGA−17−Z026−01A−01W−0746−08 TCGA−05−4410−01A−21D−1855−08 TCGA−67−3771−01 TCGA−50−5068−01A−01D−1625−08 TCGA−49−6745−01A−11D−1855−08 TCGA−44−3918−01A−01D−1105−08 TCGA−44−2665−01 TCGA−05−4397−01A−01D−1265−08 21472 TCGA−38−4632−01A−01D−1753−08 TCGA−75−5125−01A−01D−1753−08 TCGA−67−3770−01 TCGA−55−6712−01A−11D−1855−08 TCGA−50−5066−01A−01D−1625−08 TCGA−49−6767−01A−11D−1855−08 TCGA−44−4112−01 TCGA−35−3621−01A−01D−0969−08 TCGA−17−Z028−01A−01W−0746−08 TCGA−17−Z023−01A−01W−0746−08 TCGA−17−Z003−01A−01W−0746−08 TCGA−05−4382−01A−01D−1265−08 24181 TCGA−05−4427−01A−21D−1855−08 TCGA−64−5778−01A−01D−1625−08 TCGA−49−6744−01A−11D−1855−08 TCGA−44−2668−01 TCGA−17−Z022−01A−01W−0746−08 TCGA−17−Z014−01A−01W−0746−08 24617 24599 TCGA−91−6836−01A−21D−1855−08 TCGA−73−4670−01A−01D−1265−08 TCGA−67−3774−01 TCGA−64−1677−01A−01W−0928−08 TCGA−50−5936−01A−11D−1625−08 TCGA−50−5933−01A−11D−1753−08 TCGA−44−6776−01A−11D−1855−08 TCGA−17−Z050−01A−01W−0747−08 TCGA−17−Z037−01A−01W−0746−08 TCGA−17−Z017−01A−01W−0746−08 TCGA−05−4418−01A−01D−1265−08 TCGA−05−4417−01A−22D−1855−08 TCGA−05−4390−01A−02D−1753−08 TCGA−05−4249−01A−01D−1105−08 24681 24637 24605 24468 24276 24267 21442 TCGA−91−6828−01A−11D−1855−08 TCGA−75−6206−01A−11D−1753−08 TCGA−75−5126−01A−01D−1753−08 TCGA−73−4677−01A−01D−1265−08 TCGA−73−4662−01A−01D−1265−08 TCGA−73−4659−01A−01D−1265−08 TCGA−67−4679−01B−01D−1753−08 TCGA−67−3773−01 TCGA−64−5815−01A−01D−1625−08 TCGA−64−5775−01A−01D−1625−08 TCGA−64−5774−01A−01D−1625−08 TCGA−55−6642−01A−11D−1855−08 TCGA−55−1595−01A−01D−0969−08 TCGA−50−5941−01A−11D−1753−08 TCGA−50−5932−01A−11D−1753−08 TCGA−50−5051−01A−21D−1855−08 TCGA−49−4510−01A−01D−1265−08 TCGA−49−4505−01A−01D−1265−08 TCGA−44−6777−01A−11D−1855−08 TCGA−44−6146−01A−11D−1753−08 TCGA−44−6145−01A−11D−1753−08 TCGA−44−6144−01A−11D−1753−08 TCGA−38−4626−01A−01D−1553−08 TCGA−35−3615−01 TCGA−17−Z060−01A−01W−0747−08 TCGA−17−Z042−01A−01W−0746−08 TCGA−17−Z036−01A−01W−0746−08 TCGA−17−Z033−01A−01W−0746−08 TCGA−17−Z020−01A−01W−0746−08 TCGA−17−Z016−01A−01W−0746−08 TCGA−17−Z010−01A−01W−0746−08 TCGA−17−Z008−01A−01W−0746−08 TCGA−05−4433−01A−22D−1855−08 TCGA−05−4430−01A−02D−1265−08 TCGA−05−4415−01A−22D−1855−08 TCGA−05−4405−01A−21D−1855−08 TCGA−05−4403−01A−01D−1265−08 TCGA−05−4395−01A−01D−1265−08 TCGA−05−4250−01A−01D−1105−08 TCGA−05−4244−01A−01D−1105−08 27232 27224 27213 27207 27180 27178 27175 27174 24694 24691 24687 24668 24665 24662 24658 24656 24654 24653 24652 24633 24631 24623 24620 24615 24613 24582 24580 24579 24578 24576 24486 24481 24303 24299 24298 24293 24292 24279 24278 24269 24268 24252 24239 24224 24212 21468 21454 21452 21451 21438 21436

TCGA−38−4625−01A−01D−1553−08 24177 TCGA−05−4432−01A−01D−1265−08 TCGA−05−4389−01A−01D−1265−08 TCGA−44−2656−01 TCGA−05−4420−01A−01D−1265−08 21458 TCGA−91−6829−01A−21D−1855−08 TCGA−44−2666−01 TCGA−44−2662−01 TCGA−05−4422−01A−01D−1265−08 TCGA−91−6835−01A−11D−1855−08 TCGA−49−6743−01A−11D−1855−08 TCGA−49−4506−01A−01D−1265−08 TCGA−38−4631−01A−01D−1753−08 TCGA−05−5423−01A−01D−1625−08 TCGA−35−4123−01A−01D−1105−08 TCGA−17−Z046−01A−01W−0746−08 24320 TCGA−17−Z018−01A−01W−0746−08 27193 24280 TCGA−05−4410−01A−21D−1855−08 TCGA−67−3771−01 TCGA−50−5068−01A−01D−1625−08 TCGA−49−6745−01A−11D−1855−08 TCGA−44−3918−01A−01D−1105−08 TCGA−44−2665−01 TCGA−17−Z026−01A−01W−0746−08 TCGA−38−4632−01A−01D−1753−08 TCGA−05−4397−01A−01D−1265−08 21472 TCGA−75−5125−01A−01D−1753−08 TCGA−67−3770−01 TCGA−55−6712−01A−11D−1855−08 TCGA−50−5066−01A−01D−1625−08 TCGA−49−6767−01A−11D−1855−08 TCGA−44−4112−01 TCGA−35−3621−01A−01D−0969−08 TCGA−17−Z028−01A−01W−0746−08 TCGA−17−Z023−01A−01W−0746−08 TCGA−17−Z003−01A−01W−0746−08 TCGA−05−4382−01A−01D−1265−08 24181 TCGA−17−Z022−01A−01W−0746−08 TCGA−05−4427−01A−21D−1855−08 TCGA−67−3774−01 TCGA−64−5778−01A−01D−1625−08 TCGA−50−5936−01A−11D−1625−08 TCGA−49−6744−01A−11D−1855−08 TCGA−44−2668−01 TCGA−17−Z014−01A−01W−0746−08 TCGA−05−4418−01A−01D−1265−08 TCGA−05−4417−01A−22D−1855−08 TCGA−05−4390−01A−02D−1753−08 24681 24617 24605 24599 24276 21442 TCGA−91−6836−01A−21D−1855−08 TCGA−91−6828−01A−11D−1855−08 TCGA−75−6206−01A−11D−1753−08 TCGA−75−5126−01A−01D−1753−08 TCGA−73−4677−01A−01D−1265−08 TCGA−73−4670−01A−01D−1265−08 TCGA−73−4662−01A−01D−1265−08 TCGA−73−4659−01A−01D−1265−08 TCGA−67−4679−01B−01D−1753−08 TCGA−67−3773−01 TCGA−64−5815−01A−01D−1625−08 TCGA−64−5775−01A−01D−1625−08 TCGA−64−5774−01A−01D−1625−08 TCGA−64−1677−01A−01W−0928−08 TCGA−55−6642−01A−11D−1855−08 TCGA−55−1595−01A−01D−0969−08 TCGA−50−5941−01A−11D−1753−08 TCGA−50−5933−01A−11D−1753−08 TCGA−50−5932−01A−11D−1753−08 TCGA−50−5051−01A−21D−1855−08 TCGA−49−4510−01A−01D−1265−08 TCGA−49−4505−01A−01D−1265−08 TCGA−44−6777−01A−11D−1855−08 TCGA−44−6776−01A−11D−1855−08 TCGA−44−6146−01A−11D−1753−08 TCGA−44−6145−01A−11D−1753−08 TCGA−44−6144−01A−11D−1753−08 TCGA−38−4626−01A−01D−1553−08 TCGA−35−3615−01 TCGA−17−Z060−01A−01W−0747−08 TCGA−17−Z050−01A−01W−0747−08 TCGA−17−Z042−01A−01W−0746−08 TCGA−17−Z037−01A−01W−0746−08 TCGA−17−Z036−01A−01W−0746−08 TCGA−17−Z033−01A−01W−0746−08 TCGA−17−Z020−01A−01W−0746−08 TCGA−17−Z017−01A−01W−0746−08 TCGA−17−Z016−01A−01W−0746−08 TCGA−17−Z010−01A−01W−0746−08 TCGA−17−Z008−01A−01W−0746−08 TCGA−05−4433−01A−22D−1855−08 TCGA−05−4430−01A−02D−1265−08 TCGA−05−4415−01A−22D−1855−08 TCGA−05−4405−01A−21D−1855−08 TCGA−05−4403−01A−01D−1265−08 TCGA−05−4395−01A−01D−1265−08 TCGA−05−4250−01A−01D−1105−08 TCGA−05−4249−01A−01D−1105−08 TCGA−05−4244−01A−01D−1105−08 27232 27224 27213 27207 27180 27178 27175 27174 24694 24691 24687 24668 24665 24662 24658 24656 24654 24653 24652 24637 24633 24631 24623 24620 24615 24613 24582 24580 24579 24578 24576 24486 24481 24468 24303 24299 24298 24293 24292 24279 24278 24269 24268 24267 24252 24239 24224 24212 21468 21454 21452 21451 21438 21436

Signaling By PDGF FDR = 4.2e−07%, FDR nod = 1.7e−06% PDGFR Alpha Signaling Pathway FDR = 4%, FDR nod = 2.1%

PDGFRA

KRAS

SOS2 NRAS

HRAS PDGFRB

PDGFA HRAS

PTPN11 PDGFA

CDC42 GRB2

RAF1 RAF1

PAK1 PDGFB

PIK3CD SHC1

SHC1 SHC2

SHC2

STAT5B

SHC3

COL4A5 JAK1

COL4A2 SOS1

PLG GRB2

PDGFRA

COL4A4

ITGAV

COL4A1

COL6A1

ELK1

COL6A5

PIK3R1

COL9A3

THBS4

SHF

COL6A2

CAV3

FURIN

COL9A2

CRKL

COL4A3

PDGFD

FOS

PLAT

JUN

PDGFA

SPP1

RAPGEF1

THBS3

SHC1

PDGFB

THBS1

wt THBS2 PLCG1

wt

unknown CG mut COL6A3 unknown CG mut

known HCG mut COL9A1 known HCG mut PIK3CA

SOS1 PDGFRA

unknown CG mut KRAS unknown CG mut

wt PDGFRB wt

wt PIK3CB wt SOS2


known HCG mut NRAS known HCG mut SOS1


PDGFRA

PDGFA

PDGFD

PDGFB

TP53 STK11 ATM WRN BARD1 TAF1 BLM ATRIP MDM2 PRKAB1 TAF4 ATR BRCA1 BRIP1 DNA2 EXO1 HIPK2 NUAK1 PLK3 PRKAG2 PRKAG3 RFC5 TAF1L TAF3 TAF6 TOPBP1 AURKA AURKB CCNA1 CCNA2 CDK5 CHEK1 CHEK2 HIPK1 HUS1 MAPK11 MAPK14 MAPKAPK5 MRE11A NBN NOC2L PRKAA1 RAD1 RAD17 RAD50 RAD9A RBBP8 RFC2 RFC3 RHNO1 RPA2 SSRP1 TAF10 TAF2 TAF4B TAF9 TAF9B TOP3A TP53INP1 TPX2 UBC

ARHGEF6

PIK3CA

PDGFRB RASA1

NCK1

PIK3R2

STAT5A

GRB2 SHC3

PDGFB

PIK3R1

PDGFRA

COL6A6

PDGFRB

TCGA−75−5147−01A−01D−1625−08 TCGA−44−6778−01A−11D−1855−08 TCGA−05−4384−01A−01D−1753−08 TCGA−50−5936−01A−11D−1625−08 TCGA−17−Z056−01A−01W−0747−08 TCGA−50−5944−01A−11D−1753−08 TCGA−17−Z058−01A−01W−0747−08 TCGA−73−4670−01A−01D−1265−08 TCGA−49−6742−01A−11D−1855−08 TCGA−50−5072−01A−21D−1855−08 TCGA−49−4506−01A−01D−1265−08 TCGA−50−6594−01A−11D−1753−08 TCGA−17−Z057−01A−01W−0747−08 TCGA−80−5611−01A−01D−1625−08 TCGA−05−4250−01A−01D−1105−08 TCGA−75−5126−01A−01D−1753−08 TCGA−35−3615−01 TCGA−05−5428−01A−01D−1625−08 TCGA−67−6216−01A−11D−1753−08 TCGA−49−4510−01A−01D−1265−08 TCGA−44−3396−01A−01D−1265−08 TCGA−64−5779−01A−01D−1625−08 TCGA−44−6776−01A−11D−1855−08 TCGA−17−Z043−01A−01W−0746−08 TCGA−75−5146−01A−01D−1625−08 TCGA−64−1677−01A−01W−0928−08 TCGA−49−4514−01A−21D−1855−08 TCGA−17−Z026−01A−01W−0746−08 TCGA−17−Z008−01A−01W−0746−08 TCGA−50−5931−01A−11D−1753−08 TCGA−73−4676−01A−01D−1753−08 TCGA−17−Z062−01A−01W−0747−08 TCGA−05−4398−01A−01D−1265−08 TCGA−05−4244−01A−01D−1105−08 TCGA−91−6829−01A−21D−1855−08 TCGA−44−2666−01 TCGA−44−2662−01 TCGA−05−4422−01A−01D−1265−08 24605 24320 TCGA−44−3918−01A−01D−1105−08 TCGA−35−5375−01A−01D−1625−08 TCGA−73−4658−01A−01D−1753−08 TCGA−44−2656−01 TCGA−17−Z047−01A−01W−0747−08 TCGA−05−4433−01A−22D−1855−08 TCGA−67−3771−01 TCGA−91−6836−01A−21D−1855−08 TCGA−44−6774−01A−21D−1855−08 TCGA−17−Z051−01A−01W−0747−08 TCGA−17−Z045−01A−01W−0746−08 TCGA−17−Z017−01A−01W−0746−08 TCGA−05−4417−01A−22D−1855−08 TCGA−64−1676−01 TCGA−49−6743−01A−11D−1855−08 TCGA−17−Z055−01A−01W−0747−08 TCGA−64−5781−01A−01D−1625−08 TCGA−55−1596−01 TCGA−55−1592−01 TCGA−50−5045−01A−01D−1625−08 TCGA−05−4427−01A−21D−1855−08 TCGA−05−4395−01A−01D−1265−08 TCGA−50−6590−01A−12D−1855−08 TCGA−44−2661−01A−01D−1105−08 TCGA−17−Z030−01A−01W−0746−08 TCGA−05−4432−01A−01D−1265−08 TCGA−73−4668−01A−01D−1265−08 TCGA−49−6744−01A−11D−1855−08 TCGA−44−2657−01A−01D−1105−08 TCGA−38−4625−01A−01D−1553−08 TCGA−17−Z012−01A−01W−0746−08 TCGA−05−4390−01A−02D−1753−08 TCGA−91−6835−01A−11D−1855−08 TCGA−55−5899−01A−11D−1625−08 TCGA−50−6595−01A−12D−1855−08 TCGA−50−6593−01A−11D−1753−08 TCGA−17−Z033−01A−01W−0746−08 TCGA−17−Z015−01A−01W−0746−08 TCGA−05−4430−01A−02D−1265−08 TCGA−05−4249−01A−01D−1105−08 TCGA−35−3621−01A−01D−0969−08 TCGA−17−Z023−01A−01W−0746−08 TCGA−67−3770−01 TCGA−44−4112−01 TCGA−55−6712−01A−11D−1855−08 TCGA−38−4632−01A−01D−1753−08 TCGA−17−Z028−01A−01W−0746−08 21472 TCGA−75−5125−01A−01D−1753−08 TCGA−50−5066−01A−01D−1625−08 TCGA−49−6767−01A−11D−1855−08 TCGA−17−Z014−01A−01W−0746−08 TCGA−17−Z003−01A−01W−0746−08 24617 24599 24276 24181 21442 TCGA−05−4410−01A−21D−1855−08 TCGA−17−Z022−01A−01W−0746−08 TCGA−05−4397−01A−01D−1265−08 TCGA−05−4382−01A−01D−1265−08 TCGA−38−4631−01A−01D−1753−08 TCGA−91−6828−01A−11D−1855−08 TCGA−67−4679−01B−01D−1753−08 TCGA−50−5941−01A−11D−1753−08 TCGA−50−5933−01A−11D−1753−08 TCGA−17−Z049−01A−01W−0746−08 TCGA−17−Z042−01A−01W−0746−08 TCGA−05−4424−01A−22D−1855−08 TCGA−44−2668−01 TCGA−17−Z046−01A−01W−0746−08 TCGA−05−4425−01A−01D−1753−08 TCGA−05−4389−01A−01D−1265−08 TCGA−91−6831−01A−11D−1855−08 TCGA−73−4677−01A−01D−1265−08 TCGA−73−4662−01A−01D−1265−08 TCGA−64−5775−01A−01D−1625−08 TCGA−49−4488−01A−01D−1753−08 TCGA−49−4487−01A−21D−1855−08 TCGA−44−6777−01A−11D−1855−08 TCGA−44−6145−01A−11D−1753−08 TCGA−38−6178−01A−11D−1753−08 TCGA−17−Z020−01A−01W−0746−08 TCGA−17−Z010−01A−01W−0746−08 TCGA−05−5429−01A−01D−1625−08 TCGA−05−4405−01A−21D−1855−08

24681 27177 TCGA−44−6774−01A−21D−1855−08 TCGA−17−Z000−01A−01W−0746−08 TCGA−49−4486−01A−01D−1265−08 TCGA−35−5375−01A−01D−1625−08 TCGA−17−Z032−01A−01W−0746−08 TCGA−05−4398−01A−01D−1265−08 TCGA−91−6836−01A−21D−1855−08 TCGA−44−6776−01A−11D−1855−08 TCGA−50−6594−01A−11D−1753−08 TCGA−17−Z017−01A−01W−0746−08 TCGA−73−4675−01A−01D−1265−08 TCGA−44−6775−01A−11D−1855−08 TCGA−17−Z062−01A−01W−0747−08 TCGA−64−1676−01 TCGA−05−4402−01A−01D−1265−08 TCGA−05−4395−01A−01D−1265−08 21458 TCGA−67−3774−01 TCGA−64−5778−01A−01D−1625−08 TCGA−35−4123−01A−01D−1105−08 TCGA−05−4432−01A−01D−1265−08 TCGA−05−4417−01A−22D−1855−08 TCGA−50−5068−01A−01D−1625−08 TCGA−49−6745−01A−11D−1855−08 TCGA−44−3918−01A−01D−1105−08 TCGA−44−2665−01 TCGA−17−Z026−01A−01W−0746−08 TCGA−17−Z022−01A−01W−0746−08 TCGA−05−4410−01A−21D−1855−08 TCGA−49−6743−01A−11D−1855−08 TCGA−50−6590−01A−12D−1855−08 TCGA−64−1677−01A−01W−0928−08 TCGA−50−6592−01A−11D−1753−08 TCGA−50−5044−01A−21D−1855−08 TCGA−44−5645−01A−01D−1625−08 TCGA−44−5643−01A−01D−1625−08 TCGA−05−4249−01A−01D−1105−08 TCGA−67−3771−01 TCGA−38−4625−01A−01D−1553−08 TCGA−91−6829−01A−21D−1855−08 TCGA−73−4662−01A−01D−1265−08 TCGA−50−5072−01A−21D−1855−08 TCGA−17−Z049−01A−01W−0746−08 TCGA−17−Z015−01A−01W−0746−08 24177 21468 TCGA−05−4397−01A−01D−1265−08 TCGA−49−6767−01A−11D−1855−08 TCGA−44−2668−01 TCGA−17−Z028−01A−01W−0746−08 24617 24181 21472 TCGA−75−5125−01A−01D−1753−08 TCGA−67−3770−01 TCGA−55−6712−01A−11D−1855−08 TCGA−50−5066−01A−01D−1625−08 TCGA−44−4112−01 TCGA−38−4632−01A−01D−1753−08 TCGA−35−3621−01A−01D−0969−08 TCGA−17−Z023−01A−01W−0746−08 TCGA−17−Z014−01A−01W−0746−08 TCGA−17−Z003−01A−01W−0746−08 TCGA−05−4382−01A−01D−1265−08 24599 24276 21442

VEGF Signaling Pathway FDR = 9e−06%, FDR nod = 0.14%

unknown CG mut

TCGA−44−2662−01 TCGA−50−5066−01A−01D−1625−08 TCGA−73−4666−01A−01D−1265−08 TCGA−17−Z020−01A−01W−0746−08 TCGA−17−Z056−01A−01W−0747−08 TCGA−64−1678−01A−01W−0928−08 TCGA−05−4250−01A−01D−1105−08 TCGA−38−4626−01A−01D−1553−08 TCGA−44−6776−01A−11D−1855−08 TCGA−50−5044−01A−21D−1855−08 TCGA−44−6777−01A−11D−1855−08 TCGA−05−4405−01A−21D−1855−08 TCGA−50−5045−01A−01D−1625−08 TCGA−17−Z049−01A−01W−0746−08 TCGA−17−Z045−01A−01W−0746−08 TCGA−49−4487−01A−21D−1855−08 TCGA−44−6147−01A−11D−1753−08 TCGA−05−4425−01A−01D−1753−08 TCGA−55−1592−01 TCGA−44−6145−01A−11D−1753−08 TCGA−38−4630−01A−01D−1265−08 TCGA−38−4625−01A−01D−1553−08 TCGA−44−6775−01A−11D−1855−08 TCGA−64−1677−01A−01W−0928−08 TCGA−50−6597−01A−11D−1855−08 TCGA−05−4415−01A−22D−1855−08 TCGA−75−5126−01A−01D−1753−08 TCGA−49−6742−01A−11D−1855−08 TCGA−17−Z030−01A−01W−0746−08 24298 TCGA−50−5049−01A−01D−1625−08 TCGA−17−Z055−01A−01W−0747−08 TCGA−64−5779−01A−01D−1625−08 TCGA−44−3398−01A−01D−1105−08 TCGA−44−2656−01 TCGA−49−6743−01A−11D−1855−08 TCGA−17−Z046−01A−01W−0746−08 TCGA−05−4410−01A−21D−1855−08 TCGA−73−4658−01A−01D−1753−08 TCGA−44−2665−01 TCGA−44−2661−01A−01D−1105−08 TCGA−05−4418−01A−01D−1265−08 TCGA−05−4389−01A−01D−1265−08 TCGA−17−Z026−01A−01W−0746−08 TCGA−80−5611−01A−01D−1625−08 TCGA−50−6593−01A−11D−1753−08 TCGA−44−3396−01A−01D−1265−08 TCGA−17−Z042−01A−01W−0746−08 TCGA−05−4424−01A−22D−1855−08 24625 TCGA−35−3621−01A−01D−0969−08 TCGA−05−4427−01A−21D−1855−08 TCGA−38−4631−01A−01D−1753−08 TCGA−17−Z022−01A−01W−0746−08 24181 TCGA−75−6211−01A−11D−1753−08 TCGA−73−4662−01A−01D−1265−08 TCGA−44−3919−01 TCGA−17−Z057−01A−01W−0747−08 TCGA−17−Z025−01A−01W−0746−08 TCGA−17−Z023−01A−01W−0746−08 TCGA−05−4397−01A−01D−1265−08 27206 TCGA−05−4382−01A−01D−1265−08 TCGA−05−4390−01A−02D−1753−08 TCGA−64−5775−01A−01D−1625−08 TCGA−49−4486−01A−01D−1265−08 TCGA−05−4244−01A−01D−1105−08 TCGA−91−6836−01A−21D−1855−08 TCGA−73−4659−01A−01D−1265−08 TCGA−67−6215−01A−11D−1753−08 TCGA−64−5774−01A−01D−1625−08 TCGA−55−6642−01A−11D−1855−08 TCGA−55−1595−01A−01D−0969−08 TCGA−49−4510−01A−01D−1265−08 TCGA−49−4507−01A−01D−1265−08 TCGA−17−Z062−01A−01W−0747−08 TCGA−17−Z017−01A−01W−0746−08 TCGA−17−Z016−01A−01W−0746−08 TCGA−17−Z014−01A−01W−0746−08 TCGA−05−4417−01A−22D−1855−08 27207 27180 24694 24687 24680 24662 24621 24605 24293 24278 24276 21462 21451

24681 24625 TCGA−44−6776−01A−11D−1855−08 TCGA−91−6829−01A−21D−1855−08 TCGA−44−6144−01A−11D−1753−08 TCGA−67−3774−01 TCGA−35−4123−01A−01D−1105−08 TCGA−44−6778−01A−11D−1855−08 TCGA−38−4631−01A−01D−1753−08 24317 21472 TCGA−50−5068−01A−01D−1625−08 TCGA−49−6745−01A−11D−1855−08 TCGA−44−2665−01 TCGA−17−Z005−01A−01W−0746−08 TCGA−49−4505−01A−01D−1265−08 TCGA−35−3615−01 TCGA−64−5778−01A−01D−1625−08 TCGA−55−1592−01 TCGA−44−3398−01A−01D−1105−08 TCGA−73−4658−01A−01D−1753−08 TCGA−49−4514−01A−21D−1855−08 TCGA−64−1676−01 TCGA−67−6215−01A−11D−1753−08 TCGA−64−5815−01A−01D−1625−08 TCGA−49−4494−01A−01D−1265−08 TCGA−49−4488−01A−01D−1753−08 TCGA−17−Z008−01A−01W−0746−08 TCGA−05−4250−01A−01D−1105−08 24613 24268 TCGA−49−6743−01A−11D−1855−08 TCGA−50−6592−01A−11D−1753−08 TCGA−05−4249−01A−01D−1105−08 TCGA−64−1677−01A−01W−0928−08 TCGA−50−5044−01A−21D−1855−08 TCGA−44−5645−01A−01D−1625−08 TCGA−44−5643−01A−01D−1625−08 TCGA−44−2668−01 24617 TCGA−67−3771−01 TCGA−64−5781−01A−01D−1625−08 TCGA−55−5899−01A−11D−1625−08 TCGA−80−5611−01A−01D−1625−08 TCGA−55−6642−01A−11D−1855−08 TCGA−50−5072−01A−21D−1855−08 TCGA−35−4122−01A−01D−1105−08 TCGA−17−Z017−01A−01W−0746−08 TCGA−17−Z012−01A−01W−0746−08 TCGA−17−Z003−01A−01W−0746−08 TCGA−17−Z000−01A−01W−0746−08 TCGA−50−6590−01A−12D−1855−08 TCGA−44−6777−01A−11D−1855−08 TCGA−05−4382−01A−01D−1265−08 TCGA−44−3918−01A−01D−1105−08 TCGA−05−4432−01A−01D−1265−08 TCGA−75−5122−01A−01D−1753−08 TCGA−64−5779−01A−01D−1625−08 TCGA−50−5051−01A−21D−1855−08 TCGA−50−5045−01A−01D−1625−08 TCGA−44−6774−01A−21D−1855−08 TCGA−17−Z062−01A−01W−0747−08 TCGA−17−Z055−01A−01W−0747−08 TCGA−17−Z021−01A−01W−0746−08 TCGA−05−4430−01A−02D−1265−08 TCGA−50−6594−01A−11D−1753−08 TCGA−17−Z026−01A−01W−0746−08 TCGA−05−4410−01A−21D−1855−08 TCGA−50−5933−01A−11D−1753−08 TCGA−17−Z046−01A−01W−0746−08 TCGA−05−4417−01A−22D−1855−08 TCGA−05−4398−01A−01D−1265−08 TCGA−05−4397−01A−01D−1265−08 TCGA−55−1595−01A−01D−0969−08 TCGA−44−2657−01A−01D−1105−08 TCGA−38−4632−01A−01D−1753−08 TCGA−05−4424−01A−22D−1855−08 24320 24267 24181 24177 TCGA−91−6836−01A−21D−1855−08 TCGA−35−3621−01A−01D−0969−08 TCGA−17−Z045−01A−01W−0746−08 TCGA−05−4427−01A−21D−1855−08 TCGA−50−5931−01A−11D−1753−08 TCGA−17−Z022−01A−01W−0746−08 TCGA−91−6831−01A−11D−1855−08 TCGA−73−4670−01A−01D−1265−08 TCGA−64−5775−01A−01D−1625−08 TCGA−55−6712−01A−11D−1855−08 TCGA−50−5066−01A−01D−1625−08 TCGA−44−6145−01A−11D−1753−08 TCGA−35−5375−01A−01D−1625−08 TCGA−17−Z035−01A−01W−0746−08 TCGA−17−Z023−01A−01W−0746−08 TCGA−05−4405−01A−21D−1855−08 TCGA−05−4390−01A−02D−1753−08

TRIF Mediated Programmed Cell Death FDR = 0.00019%, FDR nod = 2.7e−05% Presynaptic Phase Of Homologous DNA Pairing And Strand Exchange FDR = 0.13%, FDR nod = 0.23%

unknown CG mut KDR

FLT4

wt

VEGFC

NRP2

NRP1

FIGF

PGF

ATM

unknown CG mut

FLT4

BRCA2

ITGA4

PALB2

VEGFC

BARD1

ITGA1

wt

BRIP1

ITGB1

TOP3A

AKT1

DNA2

COL1A1

MRE11A

GRB2

RAD51C

ITGA5

RAD51AP1

PIK3R1

BLM

RPS6KA1

NBN

CREB1

RAD50

FIGF

RAD51

ITGA2

RAD51D

MAP2K4

RBBP8

MAPK11

EXO1

MAPK14

RAD51B

SHC1

RTEL1

TLR4 ATR

BRCA2

ATRIP

BRIP1

DNA2

CASP8

RAD17

RAD51C

RFC2

TOPBP1

CD14

EXO1

NBN

RAD50

RAD51

FADD

RAD51D

RBBP8

HUS1

RAD1

LY96

RAD51B

RAD9A

RFC3

TICAM2

RFC5

RHNO1

RPA2

wt

SOS1

known HCG mut WRN

PIK3CA

wt RIPK3 wt TOP3A

RIPK1

known HCG mut BARD1

known HCG mut BRCA1

unknown CG mut unknown CG mut ATM

TCGA−49−6744−01A−11D−1855−08 TCGA−17−Z051−01A−01W−0747−08 TCGA−55−1594−01 TCGA−55−1595−01A−01D−0969−08 24317 TCGA−80−5611−01A−01D−1625−08 TCGA−67−6215−01A−11D−1753−08 24177 TCGA−05−4427−01A−21D−1855−08 TCGA−49−4490−01A−21D−1855−08 TCGA−17−Z040−01A−01W−0746−08 TCGA−49−4507−01A−01D−1265−08 TCGA−17−Z055−01A−01W−0747−08 TCGA−05−4390−01A−02D−1753−08 24663 TCGA−73−4659−01A−01D−1265−08 TCGA−44−2656−01 TCGA−17−Z030−01A−01W−0746−08 TCGA−73−4662−01A−01D−1265−08 TCGA−38−4630−01A−01D−1265−08 TCGA−05−4432−01A−01D−1265−08 27177 24599 TCGA−17−Z026−01A−01W−0746−08 TCGA−73−4677−01A−01D−1265−08 TCGA−17−Z015−01A−01W−0746−08 TCGA−17−Z005−01A−01W−0746−08 TCGA−44−6778−01A−11D−1855−08 TCGA−75−6211−01A−11D−1753−08 TCGA−38−4625−01A−01D−1553−08 21472 TCGA−50−5935−01A−11D−1753−08 TCGA−44−2657−01A−01D−1105−08 TCGA−50−5051−01A−21D−1855−08 TCGA−75−5126−01A−01D−1753−08 TCGA−44−6147−01A−11D−1753−08 TCGA−35−3615−01 TCGA−17−Z014−01A−01W−0746−08 TCGA−17−Z020−01A−01W−0746−08 24209 21438 TCGA−71−6725−01A−11D−1855−08 TCGA−64−1680−01 TCGA−05−4250−01A−01D−1105−08 24692 21462 TCGA−73−4676−01A−01D−1753−08 TCGA−17−Z049−01A−01W−0746−08 27173 24252 TCGA−55−5899−01A−11D−1625−08 TCGA−05−4398−01A−01D−1265−08 TCGA−50−5072−01A−21D−1855−08 TCGA−05−4405−01A−21D−1855−08 24621 TCGA−55−1592−01 TCGA−44−6775−01A−11D−1855−08 TCGA−91−6835−01A−11D−1855−08 TCGA−49−4494−01A−01D−1265−08 TCGA−05−4418−01A−01D−1265−08 TCGA−64−1676−01 TCGA−49−6767−01A−11D−1855−08 21458 TCGA−05−4402−01A−01D−1265−08 TCGA−05−4395−01A−01D−1265−08 TCGA−05−4420−01A−01D−1265−08 TCGA−44−3396−01A−01D−1265−08 TCGA−17−Z042−01A−01W−0746−08 TCGA−17−Z025−01A−01W−0746−08 24694 TCGA−49−6743−01A−11D−1855−08 TCGA−44−5643−01A−01D−1625−08 TCGA−44−2668−01 TCGA−64−1677−01A−01W−0928−08 TCGA−50−6592−01A−11D−1753−08 TCGA−44−5645−01A−01D−1625−08 TCGA−91−6836−01A−21D−1855−08 TCGA−73−4670−01A−01D−1265−08 TCGA−50−5936−01A−11D−1625−08 TCGA−17−Z053−01A−01W−0747−08 TCGA−17−Z000−01A−01W−0746−08 24481 TCGA−38−4632−01A−01D−1753−08 TCGA−17−Z046−01A−01W−0746−08 TCGA−17−Z018−01A−01W−0746−08 27193 24320 TCGA−35−4123−01A−01D−1105−08 24280 TCGA−67−3771−01 TCGA−44−6777−01A−11D−1855−08 TCGA−35−5375−01A−01D−1625−08 TCGA−17−Z045−01A−01W−0746−08 24319 TCGA−64−5779−01A−01D−1625−08 24291 24256 24181 TCGA−05−4397−01A−01D−1265−08 24617 TCGA−64−1678−01A−01W−0928−08 TCGA−17−Z028−01A−01W−0746−08 21454 TCGA−17−Z062−01A−01W−0747−08 TCGA−17−Z023−01A−01W−0746−08 TCGA−05−4417−01A−22D−1855−08 TCGA−49−4506−01A−01D−1265−08 TCGA−35−3621−01A−01D−0969−08 TCGA−17−Z060−01A−01W−0747−08 24651 24625 TCGA−50−5933−01A−11D−1753−08 TCGA−05−5428−01A−01D−1625−08 TCGA−05−4410−01A−21D−1855−08 TCGA−05−4389−01A−01D−1265−08 TCGA−50−5941−01A−11D−1753−08 TCGA−50−5044−01A−21D−1855−08 TCGA−44−3918−01A−01D−1105−08 TCGA−05−4249−01A−01D−1105−08 27206 24666 TCGA−75−5146−01A−01D−1625−08 TCGA−50−5942−01A−21D−1753−08 TCGA−44−6774−01A−21D−1855−08 TCGA−44−2666−01 TCGA−44−2662−01 TCGA−17−Z012−01A−01W−0746−08 TCGA−17−Z008−01A−01W−0746−08 24268 TCGA−64−5781−01A−01D−1625−08 TCGA−17−Z022−01A−01W−0746−08 TCGA−05−4382−01A−01D−1265−08 TCGA−73−4668−01A−01D−1265−08 TCGA−64−5775−01A−01D−1625−08 TCGA−50−6594−01A−11D−1753−08 TCGA−50−6590−01A−12D−1855−08 TCGA−50−5049−01A−01D−1625−08 TCGA−38−4631−01A−01D−1753−08 TCGA−17−Z056−01A−01W−0747−08 TCGA−17−Z017−01A−01W−0746−08 TCGA−05−4424−01A−22D−1855−08 21452 TCGA−73−4666−01A−01D−1265−08 TCGA−50−5066−01A−01D−1625−08 TCGA−44−6776−01A−11D−1855−08 TCGA−44−2659−01 TCGA−05−4430−01A−02D−1265−08 TCGA−05−4384−01A−01D−1753−08 27210 TCGA−67−3773−01 TCGA−64−5778−01A−01D−1625−08 TCGA−44−4112−01 TCGA−38−4626−01A−01D−1553−08 TCGA−17−Z057−01A−01W−0747−08 27180 24667 24633 24203 21468

TCGA−49−6743−01A−11D−1855−08 TCGA−17−Z053−01A−01W−0747−08 TCGA−17−Z014−01A−01W−0746−08 TCGA−64−1680−01 TCGA−50−5045−01A−01D−1625−08 TCGA−17−Z043−01A−01W−0746−08 TCGA−17−Z021−01A−01W−0746−08 TCGA−05−4405−01A−21D−1855−08 TCGA−67−6215−01A−11D−1753−08 TCGA−64−5815−01A−01D−1625−08 TCGA−64−1676−01 TCGA−49−4494−01A−01D−1265−08 TCGA−49−4488−01A−01D−1753−08 TCGA−17−Z008−01A−01W−0746−08 TCGA−05−4250−01A−01D−1105−08 24613 24268 TCGA−17−Z046−01A−01W−0746−08 TCGA−05−4397−01A−01D−1265−08 TCGA−55−1595−01A−01D−0969−08 TCGA−50−5933−01A−11D−1753−08 TCGA−50−5931−01A−11D−1753−08 TCGA−44−2657−01A−01D−1105−08 TCGA−38−4632−01A−01D−1753−08 TCGA−17−Z026−01A−01W−0746−08 TCGA−05−4417−01A−22D−1855−08 TCGA−05−4410−01A−21D−1855−08 TCGA−05−4398−01A−01D−1265−08 24320 24267 TCGA−67−3771−01 TCGA−17−Z055−01A−01W−0747−08 24181 24177 TCGA−71−6725−01A−11D−1855−08 TCGA−49−4506−01A−01D−1265−08 TCGA−44−6147−01A−11D−1753−08 TCGA−44−3918−01A−01D−1105−08 TCGA−38−4625−01A−01D−1553−08 TCGA−35−4123−01A−01D−1105−08 TCGA−17−Z059−01A−01W−0747−08 TCGA−17−Z025−01A−01W−0746−08 TCGA−05−4403−01A−01D−1265−08 TCGA−05−4390−01A−02D−1753−08 27207 24662 TCGA−05−4382−01A−01D−1265−08 TCGA−50−6594−01A−11D−1753−08 TCGA−50−5049−01A−01D−1625−08 TCGA−64−5781−01A−01D−1625−08 TCGA−50−6590−01A−12D−1855−08 TCGA−44−2659−01 TCGA−17−Z057−01A−01W−0747−08 TCGA−05−4424−01A−22D−1855−08 TCGA−73−4668−01A−01D−1265−08 TCGA−73−4666−01A−01D−1265−08 TCGA−67−3773−01 TCGA−64−5778−01A−01D−1625−08 TCGA−64−5775−01A−01D−1625−08 TCGA−50−5066−01A−01D−1625−08 TCGA−44−6776−01A−11D−1855−08 TCGA−44−4112−01 TCGA−38−4631−01A−01D−1753−08 TCGA−38−4626−01A−01D−1553−08 TCGA−17−Z056−01A−01W−0747−08 TCGA−17−Z022−01A−01W−0746−08 TCGA−17−Z017−01A−01W−0746−08 TCGA−05−4430−01A−02D−1265−08 TCGA−05−4384−01A−01D−1753−08 27210 27180 24667 24633 24203 21468 21452

COL1A2

BRCA1

known HCG mut FN1

known HCG mut FLT1

Homologous DNA Pairing And Strand Exchange Resolution Of D Loop Structures Through Synthesis Dependent Strand Annealing (SDSA) FDR = 1.1%, FDR nod = 1.1%

VEGFR3 Signaling In Lymphatic Endothelium FDR = 5.6%, FDR nod = 0.73%

unknown CG mut

known HCG mut

wt

KDR BRAF PIK3CG PRKCG NRAS ETS1 PIK3CA PIK3C3 PLCG1 PRKCA PRKCB PRKCE PIK3C2B PRKD3 SH2D2A ARAF MAP2K1 PIK3C2A PIK3CD PLA2G4A PRKD1 PRKCH PRKD2 PTK2 RAF1 SPHK2 AKT1 HSPB1 PIK3R3 RAC2 CASP9 HIF1A HRAS MAP2K2 MAPK14 MAPKAPK2 MAPKAPK3 NOS3 PIK3CB PIK3R1 PIK3R2 PLCG2 PRKCD PRKCI PRKCQ PRKCZ PXN SHC2

VEGF And VEGFR Signaling Network VEGF Binds To VEGFR Leading To Receptor Dimerization FDR = 1.7e−08%, FDR nod = 0.2%

WRN

MRE11A

BLM

CHEK1

TCGA−05−4395−01A−01D−1265−08 TCGA−44−5643−01A−01D−1625−08 TCGA−05−4402−01A−01D−1265−08 TCGA−49−4507−01A−01D−1265−08 TCGA−44−2665−01 TCGA−17−Z026−01A−01W−0746−08 TCGA−91−6836−01A−21D−1855−08 TCGA−17−Z057−01A−01W−0747−08 TCGA−05−5420−01A−01D−1625−08 21468 TCGA−44−2655−01 TCGA−35−4122−01A−01D−1105−08 TCGA−05−4390−01A−02D−1753−08 24177 TCGA−17−Z055−01A−01W−0747−08 TCGA−64−5781−01A−01D−1625−08 TCGA−91−6829−01A−21D−1855−08 TCGA−75−6211−01A−11D−1753−08 TCGA−73−4677−01A−01D−1265−08 TCGA−73−4659−01A−01D−1265−08 TCGA−50−6595−01A−12D−1855−08 TCGA−50−6590−01A−12D−1855−08 TCGA−50−5933−01A−11D−1753−08 TCGA−50−5068−01A−01D−1625−08 TCGA−50−5049−01A−01D−1625−08 TCGA−49−6767−01A−11D−1855−08 TCGA−49−6742−01A−11D−1855−08 TCGA−44−6777−01A−11D−1855−08 TCGA−44−6147−01A−11D−1753−08 TCGA−38−4632−01A−01D−1753−08 TCGA−38−4626−01A−01D−1553−08 TCGA−17−Z021−01A−01W−0746−08 TCGA−17−Z016−01A−01W−0746−08 TCGA−17−Z010−01A−01W−0746−08 TCGA−05−5428−01A−01D−1625−08 TCGA−05−4427−01A−21D−1855−08 TCGA−05−4424−01A−22D−1855−08 TCGA−05−4398−01A−01D−1265−08 TCGA−05−4382−01A−01D−1265−08 TCGA−05−4250−01A−01D−1105−08

TCGA−17−Z013−01A−01W−0746−08 TCGA−50−5066−01A−01D−1625−08 TCGA−73−4666−01A−01D−1265−08 TCGA−17−Z020−01A−01W−0746−08 TCGA−17−Z056−01A−01W−0747−08 TCGA−64−1678−01A−01W−0928−08 TCGA−38−4626−01A−01D−1553−08 TCGA−50−6594−01A−11D−1753−08 TCGA−05−4403−01A−01D−1265−08 TCGA−73−4670−01A−01D−1265−08 TCGA−17−Z003−01A−01W−0746−08 TCGA−44−6777−01A−11D−1855−08 TCGA−05−4405−01A−21D−1855−08 TCGA−49−6767−01A−11D−1855−08 TCGA−38−4632−01A−01D−1753−08 TCGA−49−4487−01A−21D−1855−08 TCGA−44−6147−01A−11D−1753−08 TCGA−05−4425−01A−01D−1753−08 TCGA−44−2656−01 TCGA−50−6597−01A−11D−1855−08 TCGA−05−4415−01A−22D−1855−08 TCGA−64−5781−01A−01D−1625−08 TCGA−50−5072−01A−21D−1855−08 TCGA−49−4494−01A−01D−1265−08 TCGA−55−1592−01 TCGA−44−6145−01A−11D−1753−08 TCGA−38−4630−01A−01D−1265−08 TCGA−38−4625−01A−01D−1553−08 TCGA−44−6776−01A−11D−1855−08 TCGA−44−6774−01A−21D−1855−08 TCGA−05−4432−01A−01D−1265−08 27173 TCGA−50−5044−01A−21D−1855−08 TCGA−44−6775−01A−11D−1855−08 TCGA−64−5779−01A−01D−1625−08 TCGA−05−4250−01A−01D−1105−08 TCGA−17−Z055−01A−01W−0747−08 TCGA−50−5045−01A−01D−1625−08 TCGA−44−3398−01A−01D−1105−08 TCGA−17−Z049−01A−01W−0746−08 TCGA−17−Z045−01A−01W−0746−08 TCGA−50−5049−01A−01D−1625−08 TCGA−75−5126−01A−01D−1753−08 TCGA−49−6742−01A−11D−1855−08 TCGA−17−Z030−01A−01W−0746−08 24298 TCGA−17−Z026−01A−01W−0746−08 TCGA−80−5611−01A−01D−1625−08 TCGA−50−6593−01A−11D−1753−08 TCGA−44−3396−01A−01D−1265−08 TCGA−17−Z042−01A−01W−0746−08 24625 TCGA−05−4410−01A−21D−1855−08 TCGA−17−Z046−01A−01W−0746−08 TCGA−73−4658−01A−01D−1753−08 TCGA−44−2665−01 TCGA−44−2661−01A−01D−1105−08 TCGA−05−4418−01A−01D−1265−08 TCGA−05−4389−01A−01D−1265−08 TCGA−35−3621−01A−01D−0969−08 TCGA−05−4427−01A−21D−1855−08 TCGA−38−4631−01A−01D−1753−08 24181 TCGA−75−6211−01A−11D−1753−08 TCGA−73−4662−01A−01D−1265−08 TCGA−44−3919−01 TCGA−17−Z057−01A−01W−0747−08 TCGA−17−Z025−01A−01W−0746−08 TCGA−05−4397−01A−01D−1265−08 27206 TCGA−17−Z023−01A−01W−0746−08 TCGA−17−Z022−01A−01W−0746−08 TCGA−05−4398−01A−01D−1265−08 TCGA−64−1677−01A−01W−0928−08 TCGA−05−4424−01A−22D−1855−08 TCGA−91−6829−01A−21D−1855−08 TCGA−44−6779−01A−11D−1855−08 TCGA−44−2668−01 TCGA−17−Z060−01A−01W−0747−08 TCGA−17−Z043−01A−01W−0746−08 TCGA−17−Z015−01A−01W−0746−08 TCGA−17−Z010−01A−01W−0746−08 TCGA−05−4402−01A−01D−1265−08 27201 TCGA−05−4382−01A−01D−1265−08 TCGA−64−5775−01A−01D−1625−08 TCGA−55−1595−01A−01D−0969−08 TCGA−49−4486−01A−01D−1265−08 TCGA−05−4390−01A−02D−1753−08 TCGA−05−4244−01A−01D−1105−08 TCGA−91−6836−01A−21D−1855−08 TCGA−73−4659−01A−01D−1265−08 TCGA−67−6215−01A−11D−1753−08 TCGA−64−5774−01A−01D−1625−08 TCGA−55−6642−01A−11D−1855−08 TCGA−49−4510−01A−01D−1265−08 TCGA−49−4507−01A−01D−1265−08 TCGA−17−Z062−01A−01W−0747−08 TCGA−17−Z017−01A−01W−0746−08 TCGA−17−Z016−01A−01W−0746−08 TCGA−17−Z014−01A−01W−0746−08 TCGA−05−4417−01A−22D−1855−08 27207 27180 24694 24687 24680 24662 24621 24605 24293 24278 24276 21462 21451

Constitutive Signaling By Aberrant PI3K In Cancer FDR = 2e−12%, FDR nod = 0.08% ARMS Mediated Activation FDR = 0.00051%, FDR nod = 2.1%

TCGA−17−Z045−01A−01W−0746−08 TCGA−44−6776−01A−11D−1855−08 TCGA−05−4389−01A−01D−1265−08 TCGA−17−Z030−01A−01W−0746−08 TCGA−67−3774−01 24293 TCGA−55−6642−01A−11D−1855−08 TCGA−75−5146−01A−01D−1625−08 TCGA−44−2659−01 TCGA−49−4510−01A−01D−1265−08 TCGA−50−5930−01A−11D−1753−08 TCGA−38−4626−01A−01D−1553−08 TCGA−44−6144−01A−11D−1753−08 TCGA−17−Z056−01A−01W−0747−08 TCGA−05−4405−01A−21D−1855−08 24256 TCGA−64−1676−01 TCGA−55−1594−01 TCGA−44−6775−01A−11D−1855−08 27177 TCGA−80−5611−01A−01D−1625−08 TCGA−55−1592−01 TCGA−05−4420−01A−01D−1265−08 TCGA−75−6211−01A−11D−1753−08 TCGA−05−4417−01A−22D−1855−08 TCGA−49−4505−01A−01D−1265−08 TCGA−38−4625−01A−01D−1553−08 TCGA−05−5428−01A−01D−1625−08 TCGA−73−4676−01A−01D−1753−08 27182 TCGA−17−Z011−01A−01W−0746−08 24637 24468 TCGA−64−5775−01A−01D−1625−08 27206 24581 TCGA−55−5899−01A−11D−1625−08 TCGA−73−4662−01A−01D−1265−08 24269 TCGA−75−5126−01A−01D−1753−08 TCGA−17−Z001−01A−01W−0746−08 TCGA−05−5429−01A−01D−1625−08 TCGA−44−6778−01A−11D−1855−08 TCGA−44−3918−01A−01D−1105−08 TCGA−17−Z043−01A−01W−0746−08 TCGA−49−4506−01A−01D−1265−08 TCGA−49−4514−01A−21D−1855−08 TCGA−35−4122−01A−01D−1105−08 24683 TCGA−64−5781−01A−01D−1625−08 TCGA−50−5936−01A−11D−1625−08 TCGA−49−6744−01A−11D−1855−08 TCGA−35−5375−01A−01D−1625−08 TCGA−17−Z062−01A−01W−0747−08 TCGA−17−Z015−01A−01W−0746−08 TCGA−05−4244−01A−01D−1105−08 27193 24652 24250 TCGA−50−6590−01A−12D−1855−08 TCGA−49−6743−01A−11D−1855−08 TCGA−05−4249−01A−01D−1105−08 TCGA−64−1677−01A−01W−0928−08 TCGA−50−6592−01A−11D−1753−08 TCGA−50−5044−01A−21D−1855−08 TCGA−44−5645−01A−01D−1625−08 TCGA−91−6829−01A−21D−1855−08 TCGA−17−Z046−01A−01W−0746−08 TCGA−05−4390−01A−02D−1753−08 24320 TCGA−44−2666−01 TCGA−05−4422−01A−01D−1265−08 24605 TCGA−44−2656−01 TCGA−05−4434−01A−01D−1265−08 TCGA−05−4384−01A−01D−1753−08 21468 TCGA−86−6562−01A−11D−1753−08 TCGA−64−5815−01A−01D−1625−08 TCGA−17−Z049−01A−01W−0746−08 TCGA−73−4668−01A−01D−1265−08 TCGA−44−5643−01A−01D−1625−08 TCGA−35−4123−01A−01D−1105−08 TCGA−17−Z012−01A−01W−0746−08 TCGA−44−2662−01 TCGA−17−Z050−01A−01W−0747−08 TCGA−05−4424−01A−22D−1855−08 TCGA−05−4398−01A−01D−1265−08 TCGA−50−5935−01A−11D−1753−08 TCGA−50−5931−01A−11D−1753−08 TCGA−44−6145−01A−11D−1753−08 TCGA−17−Z005−01A−01W−0746−08 TCGA−05−4397−01A−01D−1265−08 24617 TCGA−35−3621−01A−01D−0969−08 TCGA−44−2668−01 TCGA−38−4632−01A−01D−1753−08 24599 TCGA−50−5066−01A−01D−1625−08 TCGA−17−Z014−01A−01W−0746−08 24181 TCGA−75−5125−01A−01D−1753−08 TCGA−55−6712−01A−11D−1855−08 TCGA−17−Z023−01A−01W−0746−08 TCGA−17−Z003−01A−01W−0746−08 24276 21442 TCGA−50−5049−01A−01D−1625−08 TCGA−17−Z022−01A−01W−0746−08 TCGA−67−3771−01 TCGA−49−6767−01A−11D−1855−08 TCGA−05−4432−01A−01D−1265−08 TCGA−91−6836−01A−21D−1855−08 TCGA−44−4112−01 TCGA−17−Z055−01A−01W−0747−08 TCGA−05−4427−01A−21D−1855−08 TCGA−64−5778−01A−01D−1625−08 TCGA−44−6777−01A−11D−1855−08 TCGA−38−4631−01A−01D−1753−08 TCGA−17−Z028−01A−01W−0746−08 TCGA−17−Z021−01A−01W−0746−08 24191 TCGA−67−4679−01B−01D−1753−08 TCGA−17−Z010−01A−01W−0746−08 24667 24662 24245 24238 24180 21454 21438 21472 TCGA−05−4410−01A−21D−1855−08 TCGA−17−Z026−01A−01W−0746−08 TCGA−05−4382−01A−01D−1265−08 24177 TCGA−67−6217−01A−11D−1753−08 TCGA−67−3770−01 TCGA−50−6591−01A−11D−1753−08 TCGA−44−6147−01A−11D−1753−08 TCGA−38−4629−01A−02D−1265−08 TCGA−91−6835−01A−11D−1855−08 TCGA−75−6207−01A−11D−1753−08 TCGA−67−3772−01A−01W−0928−08 TCGA−50−6595−01A−12D−1855−08 TCGA−50−5944−01A−11D−1753−08 TCGA−49−4494−01A−01D−1265−08 TCGA−49−4490−01A−21D−1855−08 TCGA−38−6178−01A−11D−1753−08 TCGA−38−4628−01A−01D−1265−08 TCGA−38−4627−01A−01D−1553−08 TCGA−17−Z047−01A−01W−0747−08 TCGA−17−Z035−01A−01W−0746−08 TCGA−17−Z032−01A−01W−0746−08 TCGA−05−5423−01A−01D−1625−08 27194 27186 24682 24678 24629 24626 24621 24331 24326 24302 24301 24296 24295 24231 24230 24218 24208 24200 24193

TCGA−91−6836−01A−21D−1855−08 TCGA−05−4420−01A−01D−1265−08 TCGA−91−6831−01A−11D−1855−08 TCGA−67−3771−01 TCGA−64−5781−01A−01D−1625−08 TCGA−50−5068−01A−01D−1625−08 TCGA−50−5066−01A−01D−1625−08 TCGA−49−4487−01A−21D−1855−08 TCGA−44−3396−01A−01D−1265−08 TCGA−05−4424−01A−22D−1855−08 TCGA−73−4659−01A−01D−1265−08 TCGA−67−3770−01 TCGA−49−6743−01A−11D−1855−08 TCGA−49−4494−01A−01D−1265−08 TCGA−17−Z062−01A−01W−0747−08 TCGA−17−Z060−01A−01W−0747−08 TCGA−05−4398−01A−01D−1265−08 24662 24625 24582 24481 21472 21468 TCGA−17−Z008−01A−01W−0746−08 24268 TCGA−75−5146−01A−01D−1625−08 TCGA−50−6594−01A−11D−1753−08 TCGA−50−5942−01A−21D−1753−08 TCGA−50−5941−01A−11D−1753−08 TCGA−50−5933−01A−11D−1753−08 TCGA−50−5044−01A−21D−1855−08 TCGA−44−6774−01A−21D−1855−08 TCGA−44−3918−01A−01D−1105−08 TCGA−44−2666−01 TCGA−44−2662−01 TCGA−17−Z012−01A−01W−0746−08 TCGA−05−5428−01A−01D−1625−08 TCGA−05−4410−01A−21D−1855−08 TCGA−05−4389−01A−01D−1265−08 TCGA−05−4382−01A−01D−1265−08 TCGA−05−4249−01A−01D−1105−08 27206 24666

EGFR

unknown CG mut

TCGA−05−5715−01A−01D−1625−08 TCGA−44−6775−01A−11D−1855−08 TCGA−49−4510−01A−01D−1265−08 TCGA−17−Z056−01A−01W−0747−08 TCGA−73−4662−01A−01D−1265−08 TCGA−55−5899−01A−11D−1625−08 24269 TCGA−91−6829−01A−21D−1855−08 TCGA−75−5126−01A−01D−1753−08 TCGA−17−Z001−01A−01W−0746−08 TCGA−05−5429−01A−01D−1625−08 TCGA−64−5781−01A−01D−1625−08 TCGA−50−5936−01A−11D−1625−08 TCGA−49−6744−01A−11D−1855−08 TCGA−35−5375−01A−01D−1625−08 TCGA−17−Z062−01A−01W−0747−08 TCGA−35−3621−01A−01D−0969−08 TCGA−05−4434−01A−01D−1265−08 TCGA−86−6562−01A−11D−1753−08 TCGA−64−5815−01A−01D−1625−08 TCGA−44−2656−01 TCGA−17−Z049−01A−01W−0746−08 TCGA−05−4384−01A−01D−1753−08 21468 TCGA−73−4668−01A−01D−1265−08 TCGA−17−Z012−01A−01W−0746−08 TCGA−05−4424−01A−22D−1855−08 TCGA−50−5935−01A−11D−1753−08 TCGA−50−5931−01A−11D−1753−08 TCGA−44−6145−01A−11D−1753−08 TCGA−44−5643−01A−01D−1625−08 TCGA−44−2662−01 TCGA−35−4123−01A−01D−1105−08 TCGA−17−Z050−01A−01W−0747−08 TCGA−17−Z005−01A−01W−0746−08 TCGA−05−4398−01A−01D−1265−08 TCGA−50−5049−01A−01D−1625−08 TCGA−91−6836−01A−21D−1855−08 TCGA−44−4112−01 TCGA−17−Z022−01A−01W−0746−08 TCGA−05−4432−01A−01D−1265−08 TCGA−05−4427−01A−21D−1855−08 TCGA−67−4679−01B−01D−1753−08 TCGA−67−3771−01 TCGA−64−5778−01A−01D−1625−08 TCGA−49−6767−01A−11D−1855−08 TCGA−44−6777−01A−11D−1855−08 TCGA−38−4631−01A−01D−1753−08 TCGA−17−Z055−01A−01W−0747−08 TCGA−17−Z028−01A−01W−0746−08 TCGA−17−Z021−01A−01W−0746−08 TCGA−17−Z010−01A−01W−0746−08 24667 24662 24245 24238 24191 24180 21454 21438 TCGA−05−4410−01A−21D−1855−08 TCGA−05−4382−01A−01D−1265−08 21472 TCGA−38−4629−01A−02D−1265−08 TCGA−17−Z026−01A−01W−0746−08 24177 TCGA−91−6835−01A−11D−1855−08 TCGA−75−6207−01A−11D−1753−08 TCGA−67−6217−01A−11D−1753−08 TCGA−67−3772−01A−01W−0928−08 TCGA−67−3770−01 TCGA−50−6595−01A−12D−1855−08 TCGA−50−6591−01A−11D−1753−08 TCGA−50−5944−01A−11D−1753−08 TCGA−49−4494−01A−01D−1265−08 TCGA−49−4490−01A−21D−1855−08 TCGA−44−6147−01A−11D−1753−08 TCGA−38−6178−01A−11D−1753−08 TCGA−38−4628−01A−01D−1265−08 TCGA−38−4627−01A−01D−1553−08 TCGA−17−Z047−01A−01W−0747−08 TCGA−17−Z035−01A−01W−0746−08 TCGA−17−Z032−01A−01W−0746−08 TCGA−05−5423−01A−01D−1625−08 27194 27186 24682 24678 24629 24626 24621 24331 24326 24302 24301 24296 24295 24231 24230 24218 24208 24200 24193

TCGA−44−6775−01A−11D−1855−08 TCGA−49−4510−01A−01D−1265−08 TCGA−17−Z056−01A−01W−0747−08 TCGA−44−2657−01A−01D−1105−08 TCGA−17−Z044−01A−01W−0746−08 TCGA−73−4662−01A−01D−1265−08 TCGA−55−5899−01A−11D−1625−08 24269 TCGA−91−6829−01A−21D−1855−08 TCGA−75−5126−01A−01D−1753−08 TCGA−17−Z001−01A−01W−0746−08 TCGA−05−5429−01A−01D−1625−08 TCGA−64−5781−01A−01D−1625−08 TCGA−50−5936−01A−11D−1625−08 TCGA−49−6744−01A−11D−1855−08 TCGA−35−5375−01A−01D−1625−08 TCGA−17−Z062−01A−01W−0747−08 TCGA−35−3621−01A−01D−0969−08 TCGA−05−4434−01A−01D−1265−08 TCGA−86−6562−01A−11D−1753−08 TCGA−64−5815−01A−01D−1625−08 TCGA−44−2656−01 TCGA−17−Z049−01A−01W−0746−08 TCGA−05−4384−01A−01D−1753−08 21468 TCGA−73−4668−01A−01D−1265−08 TCGA−17−Z012−01A−01W−0746−08 TCGA−05−4424−01A−22D−1855−08 TCGA−50−5935−01A−11D−1753−08 TCGA−50−5931−01A−11D−1753−08 TCGA−44−6145−01A−11D−1753−08 TCGA−44−5643−01A−01D−1625−08 TCGA−44−2662−01 TCGA−35−4123−01A−01D−1105−08 TCGA−17−Z050−01A−01W−0747−08 TCGA−17−Z005−01A−01W−0746−08 TCGA−05−4398−01A−01D−1265−08 TCGA−50−5049−01A−01D−1625−08 TCGA−91−6836−01A−21D−1855−08 TCGA−44−4112−01 TCGA−17−Z022−01A−01W−0746−08 TCGA−05−4432−01A−01D−1265−08 TCGA−05−4427−01A−21D−1855−08 TCGA−67−4679−01B−01D−1753−08 TCGA−67−3771−01 TCGA−64−5778−01A−01D−1625−08 TCGA−49−6767−01A−11D−1855−08 TCGA−44−6777−01A−11D−1855−08 TCGA−38−4631−01A−01D−1753−08 TCGA−17−Z055−01A−01W−0747−08 TCGA−17−Z028−01A−01W−0746−08 TCGA−17−Z021−01A−01W−0746−08 TCGA−17−Z010−01A−01W−0746−08 24667 24662 24245 24238 24191 24180 21454 21438 TCGA−05−4410−01A−21D−1855−08 TCGA−05−4382−01A−01D−1265−08 21472 TCGA−38−4629−01A−02D−1265−08 TCGA−17−Z026−01A−01W−0746−08 24177 TCGA−91−6835−01A−11D−1855−08 TCGA−75−6207−01A−11D−1753−08 TCGA−67−6217−01A−11D−1753−08 TCGA−67−3772−01A−01W−0928−08 TCGA−67−3770−01 TCGA−50−6595−01A−12D−1855−08 TCGA−50−6591−01A−11D−1753−08 TCGA−50−5944−01A−11D−1753−08 TCGA−49−4494−01A−01D−1265−08 TCGA−49−4490−01A−21D−1855−08 TCGA−44−6147−01A−11D−1753−08 TCGA−38−6178−01A−11D−1753−08 TCGA−38−4628−01A−01D−1265−08 TCGA−38−4627−01A−01D−1553−08 TCGA−17−Z047−01A−01W−0747−08 TCGA−17−Z035−01A−01W−0746−08 TCGA−17−Z032−01A−01W−0746−08 TCGA−05−5423−01A−01D−1625−08 27194 27186 24682 24678 24629 24626 24621 24331 24326 24302 24301 24296 24295 24231 24230 24218 24208 24200 24193

ErbB4 Signaling Events FDR = 3%, FDR nod = 2.1% ERBB2 Regulates Cell Motility FDR = 9.4e−12%, FDR nod = 1%

BRAF

KIDINS220

NGF

RAP1A

ERBB2

wt

NRG2

EREG

HBEGF

HBEGF

NRG2

NRG4

NRG4

PTK6

unknown CG mut EGFR

ERBB4

ERBB2


EGF

ERBB3

BTC

EREG

NRG2

DIAPH1

HBEGF

NRG4

RHOA

wt NRG1

wt wt NRG1

ERBB4

known HCG mut


unknown CG mut

ERBB4 GRIN2B NRG3 ERBB2 PIK3CA JAK2 NCOR1 NRG1 PRLR CBFA2T3 FYN LRIG1 STAT5B ADAM17 NEDD4 PIK3CB BTC DLG4 EREG GRB2 MDM2 NRG2 PIK3R1 SHC1 TAB2 HBEGF ITCH NRG4 PRL STAT5A WWOX WWP1 NRG3

EGFR

ERBB4

wt wt NTRK1

ERBB2 Activates PTK6 Signaling Signaling By ERBB4 FDR = 2.2e−12%, FDR nod = 0.2%

ErbB Receptor Signaling Network FDR = 2.3e−12%, FDR nod = 0.16%

unknown CG mut EGFR ERBB4 PDGFRA NRG3 ERBB2 PDGFRB PIK3CA FGFR4 NRG1 IRS1 CD86 EGF ERBB3 FYN PTPN11 FGFR2 IRS2 KL LCK PIK3CB PIK3R2 PIK3R3 VAV1 BTC CD19 CD28 CD80 EREG FGF10 FGF19 FGF4 FGFR1 GRB2 KLB PDGFA PIK3R1 FGF1 FGF18 FGF20 FGF23 FGF3 FGF5 FGF9 FGFR3 FRS2 GAB1 HBEGF KIT NRG2 NRG4 PDGFB PIK3CD TRAT1 unknown CG mut

unknown CG mut

NRG3

ERBB2

NRG3

known HCG mut

NRG1

EGF

EGF

ERBB3

HSP90AA1

ERBB3

BTC

BTC

EREG

TCGA−17−Z058−01A−01W−0747−08 TCGA−17−Z052−01A−01W−0747−08 24681 TCGA−44−6776−01A−11D−1855−08 TCGA−44−6775−01A−11D−1855−08 24193 TCGA−67−3774−01 TCGA−49−4510−01A−01D−1265−08 TCGA−17−Z016−01A−01W−0746−08 TCGA−17−Z056−01A−01W−0747−08 TCGA−55−1592−01 TCGA−44−6778−01A−11D−1855−08 TCGA−50−6591−01A−11D−1753−08 TCGA−38−4625−01A−01D−1553−08 TCGA−17−Z032−01A−01W−0746−08 TCGA−05−5428−01A−01D−1625−08 24267 TCGA−50−5933−01A−11D−1753−08 24205 TCGA−73−4670−01A−01D−1265−08 TCGA−44−6147−01A−11D−1753−08 TCGA−05−4405−01A−21D−1855−08 TCGA−64−5775−01A−01D−1625−08 27206 24581 TCGA−80−5611−01A−01D−1625−08 TCGA−75−6211−01A−11D−1753−08 TCGA−67−3773−01 TCGA−17−Z026−01A−01W−0746−08 TCGA−05−4389−01A−01D−1265−08 TCGA−50−5051−01A−21D−1855−08 TCGA−44−2655−01 TCGA−64−5781−01A−01D−1625−08 TCGA−50−5936−01A−11D−1625−08 TCGA−49−6744−01A−11D−1855−08 TCGA−35−5375−01A−01D−1625−08 TCGA−17−Z062−01A−01W−0747−08 TCGA−91−6829−01A−21D−1855−08 TCGA−73−4677−01A−01D−1265−08 TCGA−67−6215−01A−11D−1753−08 TCGA−55−6712−01A−11D−1855−08 TCGA−17−Z027−01A−01W−0746−08 TCGA−75−5146−01A−01D−1625−08 TCGA−49−4514−01A−21D−1855−08 TCGA−05−4250−01A−01D−1105−08 27182 24252 24213 21442 TCGA−50−6590−01A−12D−1855−08 TCGA−49−6743−01A−11D−1855−08 TCGA−05−4397−01A−01D−1265−08 TCGA−50−5044−01A−21D−1855−08 24617 TCGA−64−1677−01A−01W−0928−08 TCGA−44−5645−01A−01D−1625−08 TCGA−44−2668−01 TCGA−05−4249−01A−01D−1105−08 TCGA−35−3621−01A−01D−0969−08 21472 TCGA−44−2656−01 TCGA−86−6562−01A−11D−1753−08 TCGA−64−5815−01A−01D−1625−08 TCGA−38−4629−01A−02D−1265−08 TCGA−17−Z049−01A−01W−0746−08 TCGA−05−4434−01A−01D−1265−08 TCGA−05−4384−01A−01D−1753−08 21468 TCGA−73−4668−01A−01D−1265−08 TCGA−35−4123−01A−01D−1105−08 TCGA−05−4424−01A−22D−1855−08 TCGA−50−5931−01A−11D−1753−08 TCGA−44−5643−01A−01D−1625−08 TCGA−17−Z012−01A−01W−0746−08 TCGA−05−4410−01A−21D−1855−08 TCGA−50−5935−01A−11D−1753−08 TCGA−44−6145−01A−11D−1753−08 TCGA−44−2662−01 TCGA−17−Z050−01A−01W−0747−08 TCGA−17−Z005−01A−01W−0746−08 TCGA−50−6592−01A−11D−1753−08 TCGA−44−2661−01A−01D−1105−08 TCGA−17−Z030−01A−01W−0746−08 TCGA−05−4398−01A−01D−1265−08 TCGA−75−5122−01A−01D−1753−08 TCGA−73−4658−01A−01D−1753−08 TCGA−50−6593−01A−11D−1753−08 TCGA−49−4506−01A−01D−1265−08 TCGA−49−4487−01A−21D−1855−08 TCGA−44−3918−01A−01D−1105−08 TCGA−35−4122−01A−01D−1105−08 TCGA−17−Z046−01A−01W−0746−08 TCGA−17−Z042−01A−01W−0746−08 TCGA−17−Z017−01A−01W−0746−08 TCGA−05−4418−01A−01D−1265−08 TCGA−05−4390−01A−02D−1753−08 TCGA−05−4432−01A−01D−1265−08 TCGA−05−4382−01A−01D−1265−08 TCGA−64−5778−01A−01D−1625−08 TCGA−05−4427−01A−21D−1855−08 TCGA−91−6836−01A−21D−1855−08 TCGA−67−3771−01 TCGA−44−4112−01 TCGA−50−5049−01A−01D−1625−08 TCGA−49−6767−01A−11D−1855−08 TCGA−44−6777−01A−11D−1855−08 TCGA−38−4631−01A−01D−1753−08 TCGA−17−Z022−01A−01W−0746−08 TCGA−17−Z010−01A−01W−0746−08 TCGA−67−4679−01B−01D−1753−08 TCGA−17−Z055−01A−01W−0747−08 TCGA−17−Z028−01A−01W−0746−08 TCGA−17−Z021−01A−01W−0746−08 24667 24662 24245 24238 24191 24180 21454 21438

TCGA−50−5051−01A−21D−1855−08 TCGA−44−6775−01A−11D−1855−08 TCGA−49−4510−01A−01D−1265−08 TCGA−17−Z056−01A−01W−0747−08 TCGA−73−4662−01A−01D−1265−08 TCGA−55−5899−01A−11D−1625−08 24269 TCGA−91−6829−01A−21D−1855−08 TCGA−75−5126−01A−01D−1753−08 TCGA−17−Z001−01A−01W−0746−08 TCGA−05−5429−01A−01D−1625−08 TCGA−64−5781−01A−01D−1625−08 TCGA−50−5936−01A−11D−1625−08 TCGA−49−6744−01A−11D−1855−08 TCGA−35−5375−01A−01D−1625−08 TCGA−17−Z062−01A−01W−0747−08 TCGA−35−3621−01A−01D−0969−08 TCGA−05−4434−01A−01D−1265−08 TCGA−86−6562−01A−11D−1753−08 TCGA−64−5815−01A−01D−1625−08 TCGA−44−2656−01 TCGA−17−Z049−01A−01W−0746−08 TCGA−05−4384−01A−01D−1753−08 21468 TCGA−73−4668−01A−01D−1265−08 TCGA−17−Z012−01A−01W−0746−08 TCGA−05−4424−01A−22D−1855−08 TCGA−50−5935−01A−11D−1753−08 TCGA−50−5931−01A−11D−1753−08 TCGA−44−6145−01A−11D−1753−08 TCGA−44−5643−01A−01D−1625−08 TCGA−44−2662−01 TCGA−35−4123−01A−01D−1105−08 TCGA−17−Z050−01A−01W−0747−08 TCGA−17−Z005−01A−01W−0746−08 TCGA−05−4398−01A−01D−1265−08 TCGA−50−5049−01A−01D−1625−08 TCGA−91−6836−01A−21D−1855−08 TCGA−44−4112−01 TCGA−17−Z055−01A−01W−0747−08 TCGA−17−Z022−01A−01W−0746−08 TCGA−05−4432−01A−01D−1265−08 TCGA−05−4427−01A−21D−1855−08 TCGA−67−4679−01B−01D−1753−08 TCGA−67−3771−01 TCGA−64−5778−01A−01D−1625−08 TCGA−49−6767−01A−11D−1855−08 TCGA−44−6777−01A−11D−1855−08 TCGA−38−4631−01A−01D−1753−08 TCGA−17−Z028−01A−01W−0746−08 TCGA−17−Z021−01A−01W−0746−08 TCGA−17−Z010−01A−01W−0746−08 24667 24662 24245 24238 24191 24180 21454 21438 TCGA−05−4410−01A−21D−1855−08 TCGA−05−4382−01A−01D−1265−08 21472 TCGA−38−4629−01A−02D−1265−08 TCGA−17−Z026−01A−01W−0746−08 24177 TCGA−91−6835−01A−11D−1855−08 TCGA−75−6207−01A−11D−1753−08 TCGA−67−6217−01A−11D−1753−08 TCGA−67−3772−01A−01W−0928−08 TCGA−67−3770−01 TCGA−50−6595−01A−12D−1855−08 TCGA−50−6591−01A−11D−1753−08 TCGA−50−5944−01A−11D−1753−08 TCGA−49−4494−01A−01D−1265−08 TCGA−49−4490−01A−21D−1855−08 TCGA−44−6147−01A−11D−1753−08 TCGA−38−6178−01A−11D−1753−08 TCGA−38−4628−01A−01D−1265−08 TCGA−38−4627−01A−01D−1553−08 TCGA−17−Z047−01A−01W−0747−08 TCGA−17−Z035−01A−01W−0746−08 TCGA−17−Z032−01A−01W−0746−08 TCGA−05−5423−01A−01D−1625−08 27194 27186 24682 24678 24629 24626 24621 24331 24326 24302 24301 24296 24295 24231 24230 24218 24208 24200 24193

Heterotrimeric GPCR Signaling Pathway (through Glutamate, G Alpha Q And PLC Beta) ( GPCR GroupI Metabotropic Glutamate Receptor Signaling Pathway ) FDR = 0.00071%, FDR nod = 0.46% G1 To S Cell Cycle Control FDR = 2e−12%, FDR nod = 0.046%

TCGA−05−4427−01A−21D−1855−08 TCGA−17−Z014−01A−01W−0746−08 24617 21454 TCGA−05−4415−01A−22D−1855−08 TCGA−49−4510−01A−01D−1265−08 TCGA−05−4390−01A−02D−1753−08 24663 TCGA−49−4486−01A−01D−1265−08 TCGA−44−2656−01 24177 TCGA−73−4677−01A−01D−1265−08 TCGA−17−Z022−01A−01W−0746−08 TCGA−05−4417−01A−22D−1855−08 TCGA−64−1676−01 TCGA−50−5935−01A−11D−1753−08 TCGA−44−2657−01A−01D−1105−08 21472 TCGA−73−4676−01A−01D−1753−08 TCGA−17−Z049−01A−01W−0746−08 27173 24252 21462 TCGA−91−6835−01A−11D−1855−08 TCGA−55−1592−01 TCGA−49−4494−01A−01D−1265−08 TCGA−44−6775−01A−11D−1855−08 TCGA−05−4418−01A−01D−1265−08 TCGA−05−4424−01A−22D−1855−08 TCGA−50−5072−01A−21D−1855−08 TCGA−05−4405−01A−21D−1855−08 TCGA−05−4398−01A−01D−1265−08 24621 21452 TCGA−73−4666−01A−01D−1265−08 TCGA−44−2659−01 TCGA−91−6831−01A−11D−1855−08 TCGA−67−6217−01A−11D−1753−08 TCGA−50−5931−01A−11D−1753−08 TCGA−49−4505−01A−01D−1265−08 TCGA−44−6145−01A−11D−1753−08 TCGA−44−5645−01A−01D−1625−08 TCGA−35−3621−01A−01D−0969−08 TCGA−17−Z056−01A−01W−0747−08 TCGA−67−3771−01 TCGA−64−5781−01A−01D−1625−08 TCGA−64−5779−01A−01D−1625−08 TCGA−44−6777−01A−11D−1855−08 TCGA−38−4631−01A−01D−1753−08 TCGA−35−5375−01A−01D−1625−08 TCGA−17−Z045−01A−01W−0746−08 TCGA−17−Z017−01A−01W−0746−08 TCGA−05−4430−01A−02D−1265−08 24319 24291 24256 24181 TCGA−05−5428−01A−01D−1625−08 TCGA−05−4389−01A−01D−1265−08 TCGA−05−4410−01A−21D−1855−08 TCGA−75−5146−01A−01D−1625−08 TCGA−50−6594−01A−11D−1753−08 TCGA−50−5942−01A−21D−1753−08 TCGA−50−5941−01A−11D−1753−08 TCGA−50−5933−01A−11D−1753−08 TCGA−50−5044−01A−21D−1855−08 TCGA−44−6774−01A−21D−1855−08 TCGA−44−2666−01 TCGA−44−2662−01 TCGA−17−Z012−01A−01W−0746−08 TCGA−17−Z008−01A−01W−0746−08 27206 24666 24268 TCGA−55−5899−01A−11D−1625−08 TCGA−17−Z026−01A−01W−0746−08 TCGA−05−4382−01A−01D−1265−08 TCGA−44−3918−01A−01D−1105−08 TCGA−17−Z028−01A−01W−0746−08 TCGA−05−4249−01A−01D−1105−08 TCGA−73−4662−01A−01D−1265−08 TCGA−50−6595−01A−12D−1855−08 TCGA−50−6590−01A−12D−1855−08 TCGA−50−5049−01A−01D−1625−08 TCGA−49−6742−01A−11D−1855−08 TCGA−44−4112−01 TCGA−44−2665−01 TCGA−38−4629−01A−02D−1265−08 TCGA−17−Z033−01A−01W−0746−08 TCGA−17−Z030−01A−01W−0746−08 TCGA−17−Z015−01A−01W−0746−08 TCGA−17−Z010−01A−01W−0746−08 TCGA−17−Z001−01A−01W−0746−08 TCGA−05−5715−01A−01D−1625−08 TCGA−05−4432−01A−01D−1265−08 TCGA−05−4426−01A−01D−1265−08

TCGA−17−Z051−01A−01W−0747−08 TCGA−05−4250−01A−01D−1105−08 24293 TCGA−73−4659−01A−01D−1265−08 TCGA−67−6215−01A−11D−1753−08 TCGA−64−5774−01A−01D−1625−08 TCGA−55−6642−01A−11D−1855−08 TCGA−55−1595−01A−01D−0969−08 TCGA−49−4510−01A−01D−1265−08 TCGA−49−4507−01A−01D−1265−08 TCGA−49−4486−01A−01D−1265−08 TCGA−17−Z016−01A−01W−0746−08 TCGA−17−Z014−01A−01W−0746−08 TCGA−05−4417−01A−22D−1855−08 TCGA−05−4390−01A−02D−1753−08 TCGA−05−4244−01A−01D−1105−08 27207 27180 24694 24687 24680 24662 24605 24278 24276 21462 21451 TCGA−91−6836−01A−21D−1855−08 TCGA−64−5775−01A−01D−1625−08 TCGA−55−1592−01 TCGA−44−6147−01A−11D−1753−08 TCGA−35−4122−01A−01D−1105−08 TCGA−35−3621−01A−01D−0969−08 TCGA−17−Z062−01A−01W−0747−08 TCGA−17−Z017−01A−01W−0746−08 TCGA−05−4382−01A−01D−1265−08 24667 24621 24600 21454 TCGA−91−6831−01A−11D−1855−08 TCGA−91−6829−01A−21D−1855−08 TCGA−75−6211−01A−11D−1753−08 TCGA−75−6207−01A−11D−1753−08 TCGA−75−5147−01A−01D−1625−08 TCGA−75−5146−01A−01D−1625−08 TCGA−75−5125−01A−01D−1753−08 TCGA−73−4676−01A−01D−1753−08 TCGA−73−4670−01A−01D−1265−08 TCGA−73−4666−01A−01D−1265−08 TCGA−67−3771−01 TCGA−67−3770−01 TCGA−64−5778−01A−01D−1625−08 TCGA−64−1678−01A−01W−0928−08 TCGA−64−1677−01A−01W−0928−08 TCGA−64−1676−01 TCGA−55−6712−01A−11D−1855−08 TCGA−55−5899−01A−11D−1625−08 TCGA−55−1596−01 TCGA−55−1594−01 TCGA−50−6595−01A−12D−1855−08 TCGA−50−6594−01A−11D−1753−08 TCGA−50−6593−01A−11D−1753−08 TCGA−50−6592−01A−11D−1753−08 TCGA−50−6591−01A−11D−1753−08 TCGA−50−6590−01A−12D−1855−08 TCGA−50−5946−01A−11D−1753−08 TCGA−50−5944−01A−11D−1753−08 TCGA−50−5941−01A−11D−1753−08 TCGA−50−5939−01A−11D−1625−08 TCGA−50−5933−01A−11D−1753−08 TCGA−50−5931−01A−11D−1753−08 TCGA−50−5068−01A−01D−1625−08 TCGA−50−5066−01A−01D−1625−08 TCGA−50−5049−01A−01D−1625−08 TCGA−50−5045−01A−01D−1625−08 TCGA−49−6767−01A−11D−1855−08 TCGA−49−4514−01A−21D−1855−08 TCGA−49−4505−01A−01D−1265−08 TCGA−49−4490−01A−21D−1855−08 TCGA−49−4487−01A−21D−1855−08 TCGA−44−6779−01A−11D−1855−08 TCGA−44−6778−01A−11D−1855−08 TCGA−44−6777−01A−11D−1855−08 TCGA−44−6775−01A−11D−1855−08 TCGA−44−6774−01A−21D−1855−08 TCGA−44−6145−01A−11D−1753−08 TCGA−44−6144−01A−11D−1753−08 TCGA−44−5645−01A−01D−1625−08 TCGA−44−5643−01A−01D−1625−08 TCGA−44−3918−01A−01D−1105−08 TCGA−44−3396−01A−01D−1265−08 TCGA−44−2668−01 TCGA−44−2666−01 TCGA−44−2662−01 TCGA−44−2659−01 TCGA−44−2656−01 TCGA−38−6178−01A−11D−1753−08 TCGA−38−4632−01A−01D−1753−08 TCGA−38−4630−01A−01D−1265−08 TCGA−38−4629−01A−02D−1265−08 TCGA−38−4625−01A−01D−1553−08 TCGA−35−5375−01A−01D−1625−08 TCGA−35−4123−01A−01D−1105−08 TCGA−17−Z061−01A−01W−0747−08 TCGA−17−Z057−01A−01W−0747−08 TCGA−17−Z056−01A−01W−0747−08 TCGA−17−Z055−01A−01W−0747−08 TCGA−17−Z053−01A−01W−0747−08 TCGA−17−Z052−01A−01W−0747−08 TCGA−17−Z049−01A−01W−0746−08 TCGA−17−Z047−01A−01W−0747−08 TCGA−17−Z046−01A−01W−0746−08 TCGA−17−Z045−01A−01W−0746−08 TCGA−17−Z044−01A−01W−0746−08 TCGA−17−Z043−01A−01W−0746−08 TCGA−17−Z042−01A−01W−0746−08 TCGA−17−Z037−01A−01W−0746−08 TCGA−17−Z035−01A−01W−0746−08 TCGA−17−Z030−01A−01W−0746−08 TCGA−17−Z028−01A−01W−0746−08 TCGA−17−Z027−01A−01W−0746−08 TCGA−17−Z026−01A−01W−0746−08 TCGA−17−Z023−01A−01W−0746−08 TCGA−17−Z022−01A−01W−0746−08 TCGA−17−Z021−01A−01W−0746−08 TCGA−17−Z020−01A−01W−0746−08 TCGA−17−Z015−01A−01W−0746−08 TCGA−17−Z012−01A−01W−0746−08 TCGA−17−Z007−01A−01W−0746−08 TCGA−17−Z005−01A−01W−0746−08 TCGA−17−Z003−01A−01W−0746−08 TCGA−17−Z001−01A−01W−0746−08 TCGA−05−5428−01A−01D−1625−08 TCGA−05−5423−01A−01D−1625−08 TCGA−05−4433−01A−22D−1855−08 TCGA−05−4432−01A−01D−1265−08 TCGA−05−4430−01A−02D−1265−08 TCGA−05−4427−01A−21D−1855−08 TCGA−05−4426−01A−01D−1265−08 TCGA−05−4424−01A−22D−1855−08 TCGA−05−4420−01A−01D−1265−08 TCGA−05−4410−01A−21D−1855−08 TCGA−05−4405−01A−21D−1855−08 TCGA−05−4402−01A−01D−1265−08 TCGA−05−4398−01A−01D−1265−08 TCGA−05−4397−01A−01D−1265−08 TCGA−05−4395−01A−01D−1265−08 TCGA−05−4384−01A−01D−1753−08 27224 27210 27206 27201 27197 27193 27188 27185 27182 27178 27175 27173 24693 24689 24682 24681 24678 24669 24665 24663 24656 24653 24633 24625 24623 24617 24607 24599 24598 24597 24486 24468 24331 24320 24319 24317 24312 24302 24301 24295 24292 24291 24289 24279 24270 24269 24256 24252 24250 24245 24239 24238 24205 24177 21472 21468 21452 21442 21438

Interleukin Signaling Pathway FDR = 0.24%, FDR nod = 4.8% Integrated Breast Cancer Pathway FDR = 2e−12%, FDR nod = 0.23%

BRAF TP53

PRKCB ATM

ARAF CDC25A

PRKCH GADD45A

PRKCD MYC

GNB5 PCNA

27173 TCGA−44−2661−01A−01D−1105−08 TCGA−17−Z056−01A−01W−0747−08 TCGA−73−4662−01A−01D−1265−08 TCGA−05−5423−01A−01D−1625−08 24681 TCGA−49−4512−01A−21D−1855−08 24625 TCGA−17−Z015−01A−01W−0746−08 21452 TCGA−50−5932−01A−11D−1753−08 TCGA−50−5045−01A−01D−1625−08 TCGA−17−Z014−01A−01W−0746−08 TCGA−50−5066−01A−01D−1625−08 TCGA−44−2656−01 TCGA−49−4505−01A−01D−1265−08 TCGA−17−Z030−01A−01W−0746−08 TCGA−67−3773−01 TCGA−05−5715−01A−01D−1625−08 TCGA−17−Z023−01A−01W−0746−08 24296 24318 24181 TCGA−44−6775−01A−11D−1855−08 TCGA−50−5936−01A−11D−1625−08 TCGA−17−Z045−01A−01W−0746−08 24317 TCGA−73−4668−01A−01D−1265−08 21454 24667 24600 TCGA−05−4418−01A−01D−1265−08 TCGA−17−Z058−01A−01W−0747−08 TCGA−73−4658−01A−01D−1753−08 TCGA−67−6217−01A−11D−1753−08 TCGA−05−4420−01A−01D−1265−08 TCGA−35−3621−01A−01D−0969−08 TCGA−91−6831−01A−11D−1855−08 TCGA−75−5122−01A−01D−1753−08 TCGA−64−5778−01A−01D−1625−08 24267 24205 TCGA−44−4112−01 TCGA−44−6144−01A−11D−1753−08 TCGA−05−5429−01A−01D−1625−08 TCGA−49−6745−01A−11D−1855−08 TCGA−50−5068−01A−01D−1625−08 TCGA−44−2665−01 TCGA−64−1677−01A−01W−0928−08 TCGA−44−5645−01A−01D−1625−08 TCGA−44−2668−01 TCGA−50−5930−01A−11D−1753−08 21473 21462 TCGA−44−6778−01A−11D−1855−08 TCGA−55−6712−01A−11D−1855−08 TCGA−17−Z055−01A−01W−0747−08 TCGA−55−1592−01 TCGA−17−Z025−01A−01W−0746−08 TCGA−05−4415−01A−22D−1855−08 21472 TCGA−64−1676−01 TCGA−50−5935−01A−11D−1753−08 TCGA−50−5072−01A−21D−1855−08 TCGA−05−4430−01A−02D−1265−08 TCGA−05−4405−01A−21D−1855−08 TCGA−17−Z013−01A−01W−0746−08 24177 24653 TCGA−17−Z057−01A−01W−0747−08 24599 TCGA−05−4417−01A−22D−1855−08 TCGA−50−6592−01A−11D−1753−08 TCGA−73−4677−01A−01D−1265−08 TCGA−55−1596−01 TCGA−55−5899−01A−11D−1625−08 TCGA−17−Z062−01A−01W−0747−08 TCGA−67−3774−01 TCGA−44−6777−01A−11D−1855−08 24245 TCGA−05−4427−01A−21D−1855−08 TCGA−17−Z026−01A−01W−0746−08 TCGA−17−Z053−01A−01W−0747−08 TCGA−80−5611−01A−01D−1625−08 TCGA−91−6828−01A−11D−1855−08 TCGA−38−4625−01A−01D−1553−08 TCGA−17−Z017−01A−01W−0746−08 TCGA−44−2659−01 TCGA−05−4424−01A−22D−1855−08 TCGA−05−4250−01A−01D−1105−08 TCGA−38−4632−01A−01D−1753−08 TCGA−17−Z046−01A−01W−0746−08 TCGA−17−Z018−01A−01W−0746−08 27193 24320 24280 24256 TCGA−44−2657−01A−01D−1105−08 TCGA−17−Z016−01A−01W−0746−08 TCGA−49−6744−01A−11D−1855−08 24278 24200 TCGA−05−4397−01A−01D−1265−08 TCGA−91−6835−01A−11D−1855−08 TCGA−64−1678−01A−01W−0928−08 TCGA−17−Z042−01A−01W−0746−08 TCGA−17−Z000−01A−01W−0746−08 TCGA−49−6742−01A−11D−1855−08 TCGA−17−Z028−01A−01W−0746−08 24604 TCGA−67−3771−01 TCGA−05−4432−01A−01D−1265−08 TCGA−50−5049−01A−01D−1625−08 TCGA−49−4506−01A−01D−1265−08 TCGA−44−5643−01A−01D−1625−08 24683 24617 21468 TCGA−49−6767−01A−11D−1855−08 TCGA−49−4514−01A−21D−1855−08 TCGA−35−4122−01A−01D−1105−08 TCGA−50−6590−01A−12D−1855−08 TCGA−91−6836−01A−21D−1855−08 TCGA−64−5781−01A−01D−1625−08 TCGA−49−6743−01A−11D−1855−08 TCGA−35−4123−01A−01D−1105−08 TCGA−17−Z022−01A−01W−0746−08 TCGA−49−4486−01A−01D−1265−08 TCGA−44−3398−01A−01D−1105−08 TCGA−38−4631−01A−01D−1753−08 TCGA−17−Z032−01A−01W−0746−08 TCGA−91−6829−01A−21D−1855−08 TCGA−75−5126−01A−01D−1753−08 TCGA−67−4679−01B−01D−1753−08 TCGA−64−5779−01A−01D−1625−08 TCGA−44−6145−01A−11D−1753−08 TCGA−17−Z021−01A−01W−0746−08 TCGA−05−5428−01A−01D−1625−08 TCGA−44−6774−01A−21D−1855−08 TCGA−44−3918−01A−01D−1105−08 TCGA−05−4410−01A−21D−1855−08 TCGA−05−4382−01A−01D−1265−08 TCGA−75−5146−01A−01D−1625−08 TCGA−50−6594−01A−11D−1753−08 TCGA−50−5941−01A−11D−1753−08 TCGA−50−5933−01A−11D−1753−08 TCGA−50−5044−01A−21D−1855−08 TCGA−44−2662−01 TCGA−17−Z012−01A−01W−0746−08 TCGA−17−Z008−01A−01W−0746−08 TCGA−05−4389−01A−01D−1265−08 TCGA−05−4249−01A−01D−1105−08 TCGA−50−5942−01A−21D−1753−08 TCGA−44−2666−01 27206 24666 24268

TCGA−49−6743−01A−11D−1855−08 TCGA−75−5122−01A−01D−1753−08 TCGA−49−4501−01A−01D−1265−08 24225 TCGA−44−2655−01 27177 TCGA−49−6744−01A−11D−1855−08 24267 TCGA−73−4662−01A−01D−1265−08 24579 TCGA−73−4677−01A−01D−1265−08 TCGA−44−6776−01A−11D−1855−08 TCGA−50−5935−01A−11D−1753−08 TCGA−35−3615−01 TCGA−73−4668−01A−01D−1265−08 TCGA−50−5051−01A−21D−1855−08 TCGA−49−6745−01A−11D−1855−08 27192 TCGA−71−6725−01A−11D−1855−08 TCGA−17−Z059−01A−01W−0747−08 TCGA−05−4250−01A−01D−1105−08 TCGA−64−5779−01A−01D−1625−08 TCGA−75−5126−01A−01D−1753−08 24298 TCGA−17−Z060−01A−01W−0747−08 TCGA−17−Z010−01A−01W−0746−08 TCGA−05−5429−01A−01D−1625−08 TCGA−67−6216−01A−11D−1753−08 TCGA−05−5715−01A−01D−1625−08 TCGA−91−6828−01A−11D−1855−08 TCGA−17−Z051−01A−01W−0747−08 TCGA−05−4415−01A−22D−1855−08 TCGA−44−3398−01A−01D−1105−08 24609 24261 TCGA−17−Z036−01A−01W−0746−08 TCGA−67−3773−01 TCGA−17−Z033−01A−01W−0746−08 TCGA−67−3774−01 TCGA−75−6206−01A−11D−1753−08 TCGA−44−3919−01 TCGA−64−5781−01A−01D−1625−08 TCGA−17−Z025−01A−01W−0746−08 TCGA−50−6597−01A−11D−1855−08 TCGA−50−5055−01A−01D−1625−08 TCGA−44−4112−01 TCGA−67−4679−01B−01D−1753−08 TCGA−05−4422−01A−01D−1265−08 TCGA−05−4425−01A−01D−1753−08 24333 24318 TCGA−80−5611−01A−01D−1625−08 TCGA−49−6742−01A−11D−1855−08 TCGA−17−Z018−01A−01W−0746−08 TCGA−55−6543−01A−11D−1753−08 TCGA−50−5936−01A−11D−1625−08 TCGA−17−Z000−01A−01W−0746−08 TCGA−05−5420−01A−01D−1625−08 TCGA−50−5044−01A−21D−1855−08 TCGA−05−4389−01A−01D−1265−08 TCGA−50−5942−01A−21D−1753−08 TCGA−17−Z008−01A−01W−0746−08 TCGA−05−4249−01A−01D−1105−08 24666 24268 TCGA−38−4631−01A−01D−1753−08 TCGA−50−5072−01A−21D−1855−08 24181 TCGA−73−4658−01A−01D−1753−08 TCGA−44−2657−01A−01D−1105−08 TCGA−49−4488−01A−01D−1753−08 TCGA−17−Z040−01A−01W−0746−08 27235 24330 21453 TCGA−17−Z032−01A−01W−0746−08 TCGA−91−6835−01A−11D−1855−08 24200 24193 TCGA−67−6217−01A−11D−1753−08 TCGA−67−3772−01A−01W−0928−08 TCGA−49−4494−01A−01D−1265−08 TCGA−38−4628−01A−01D−1265−08 TCGA−38−4627−01A−01D−1553−08 27194 27186 24629 24626 24326 24296 24231 24230 24218 24208 TCGA−05−4417−01A−22D−1855−08 TCGA−73−4659−01A−01D−1265−08 TCGA−49−4510−01A−01D−1265−08 TCGA−49−4486−01A−01D−1265−08 TCGA−05−4390−01A−02D−1753−08 24694 24293 24276 21462 TCGA−67−6215−01A−11D−1753−08 TCGA−64−5774−01A−01D−1625−08 TCGA−55−6642−01A−11D−1855−08 TCGA−55−1595−01A−01D−0969−08 TCGA−49−4507−01A−01D−1265−08 TCGA−17−Z016−01A−01W−0746−08 TCGA−17−Z014−01A−01W−0746−08 TCGA−05−4244−01A−01D−1105−08 27207 27180 24687 24680 24662 24605 24278 21451 TCGA−05−4427−01A−21D−1855−08 TCGA−67−3771−01 TCGA−44−6775−01A−11D−1855−08 TCGA−91−6829−01A−21D−1855−08 TCGA−44−6774−01A−21D−1855−08 TCGA−17−Z022−01A−01W−0746−08 TCGA−05−4382−01A−01D−1265−08 21472 TCGA−91−6836−01A−21D−1855−08 TCGA−64−5775−01A−01D−1625−08 TCGA−50−6594−01A−11D−1753−08 TCGA−50−5941−01A−11D−1753−08 TCGA−17−Z062−01A−01W−0747−08 TCGA−17−Z015−01A−01W−0746−08 TCGA−05−4410−01A−21D−1855−08 TCGA−05−4397−01A−01D−1265−08 TCGA−64−1676−01 TCGA−50−6593−01A−11D−1753−08 TCGA−50−5933−01A−11D−1753−08 TCGA−50−5049−01A−01D−1625−08 TCGA−49−6767−01A−11D−1855−08 TCGA−44−3918−01A−01D−1105−08 TCGA−44−2668−01 TCGA−38−4625−01A−01D−1553−08 TCGA−35−4123−01A−01D−1105−08 TCGA−17−Z049−01A−01W−0746−08 TCGA−17−Z042−01A−01W−0746−08 TCGA−17−Z026−01A−01W−0746−08 TCGA−17−Z017−01A−01W−0746−08 TCGA−05−4432−01A−01D−1265−08 TCGA−05−4424−01A−22D−1855−08 TCGA−05−4398−01A−01D−1265−08 24621 TCGA−91−6831−01A−11D−1855−08 TCGA−75−6211−01A−11D−1753−08 TCGA−73−4676−01A−01D−1753−08 TCGA−73−4666−01A−01D−1265−08 TCGA−67−3770−01 TCGA−64−1677−01A−01W−0928−08 TCGA−55−1592−01 TCGA−50−5931−01A−11D−1753−08 TCGA−49−4514−01A−21D−1855−08 TCGA−49−4490−01A−21D−1855−08 TCGA−44−6145−01A−11D−1753−08 TCGA−44−6144−01A−11D−1753−08 TCGA−44−3396−01A−01D−1265−08 TCGA−44−2662−01 TCGA−44−2656−01 TCGA−38−4629−01A−02D−1265−08 TCGA−35−5375−01A−01D−1625−08 TCGA−35−3621−01A−01D−0969−08 TCGA−17−Z055−01A−01W−0747−08 TCGA−17−Z047−01A−01W−0747−08 TCGA−17−Z046−01A−01W−0746−08 TCGA−17−Z045−01A−01W−0746−08 TCGA−17−Z043−01A−01W−0746−08 TCGA−17−Z035−01A−01W−0746−08 TCGA−17−Z027−01A−01W−0746−08 TCGA−05−5428−01A−01D−1625−08 TCGA−05−4405−01A−21D−1855−08 27173 24331 24317 24177 21468 21438 TCGA−75−6207−01A−11D−1753−08 TCGA−75−5146−01A−01D−1625−08 TCGA−75−5125−01A−01D−1753−08 TCGA−64−5778−01A−01D−1625−08 TCGA−64−1678−01A−01W−0928−08 TCGA−55−6712−01A−11D−1855−08 TCGA−55−5899−01A−11D−1625−08 TCGA−55−1596−01 TCGA−55−1594−01 TCGA−50−6595−01A−12D−1855−08 TCGA−50−6592−01A−11D−1753−08 TCGA−50−6591−01A−11D−1753−08 TCGA−50−6590−01A−12D−1855−08 TCGA−50−5946−01A−11D−1753−08 TCGA−50−5944−01A−11D−1753−08 TCGA−50−5068−01A−01D−1625−08 TCGA−50−5066−01A−01D−1625−08 TCGA−50−5045−01A−01D−1625−08 TCGA−44−6779−01A−11D−1855−08 TCGA−44−6777−01A−11D−1855−08 TCGA−44−6147−01A−11D−1753−08 TCGA−44−2666−01 TCGA−44−2659−01 TCGA−38−6178−01A−11D−1753−08 TCGA−38−4630−01A−01D−1265−08 TCGA−35−4122−01A−01D−1105−08 TCGA−17−Z061−01A−01W−0747−08 TCGA−17−Z057−01A−01W−0747−08 TCGA−17−Z056−01A−01W−0747−08 TCGA−17−Z053−01A−01W−0747−08 TCGA−17−Z044−01A−01W−0746−08 TCGA−17−Z037−01A−01W−0746−08 TCGA−17−Z030−01A−01W−0746−08 TCGA−17−Z028−01A−01W−0746−08 TCGA−17−Z023−01A−01W−0746−08 TCGA−17−Z020−01A−01W−0746−08 TCGA−17−Z012−01A−01W−0746−08 TCGA−17−Z007−01A−01W−0746−08 TCGA−05−5423−01A−01D−1625−08 TCGA−05−4420−01A−01D−1265−08 TCGA−05−4402−01A−01D−1265−08 TCGA−05−4384−01A−01D−1753−08 27210 27206 27201 27197 24682 24678 24667 24656 24633 24625 24617 24600 24599 24598 24319 24302 24301 24295 24291 24256 24239 21454 TCGA−75−5147−01A−01D−1625−08 TCGA−73−4670−01A−01D−1265−08 TCGA−50−5939−01A−11D−1625−08 TCGA−49−4505−01A−01D−1265−08 TCGA−49−4487−01A−21D−1855−08 TCGA−44−6778−01A−11D−1855−08 TCGA−44−5645−01A−01D−1625−08 TCGA−44−5643−01A−01D−1625−08 TCGA−38−4632−01A−01D−1753−08 TCGA−17−Z052−01A−01W−0747−08 TCGA−17−Z021−01A−01W−0746−08 TCGA−17−Z005−01A−01W−0746−08 TCGA−17−Z003−01A−01W−0746−08 TCGA−17−Z001−01A−01W−0746−08 TCGA−05−4433−01A−22D−1855−08 TCGA−05−4430−01A−02D−1265−08 TCGA−05−4426−01A−01D−1265−08 TCGA−05−4395−01A−01D−1265−08 27224 27193 27188 27185 27182 27178 27175 24693 24689 24681 24669 24665 24663 24653 24623 24607 24597 24486 24468 24320 24312 24292 24289 24279 24270 24269 24252 24250 24245 24238 24205 21452 21442

MAPK3 (ERK1) Activation FDR = 0.012%, FDR nod = 1% MAPK1 (ERK2) Activation FDR = 0.23%, FDR nod = 2.8%


JAK1 JAK1


wt wt

PTPN11

PTPN11

IL6R

IL6R

TYK2

TYK2

MAP2K1

CDK1

MAP2K2


wt wt

wt PRKCA wt

known HCG mut PRKCG known HCG mut

unknown CG mut BRAF MTOR IRS1 STAT3 JAK3 NRAS IL12RB2 RPS6KA2 RPS6KA6 AKT3 MAPK6 MAPK7 ARAF IL12RB1 IL5RA MKNK2 PIK3CA SOS1 STAT1 STAT5B AKT2 CDKN1B ELK4 FOXO3 MYC STAT2 AKT1 CHUK CXCR1 CXCR2 FOS GSK3B IKBKB IL10 IL10RB IL13RA2 IL15 IL17A IL17F IL1A IL20RA IL21 IL6R MKNK1 RASA1 RPS6KA1 RPS6KA3 SHC1 SOS2 SPIC STAT4 STAT5A CDKN1A ELK1 ELK3 IL10RA IL13 IL15RA IL2 IL2RA IL2RB IL4R IRS2 MAPK15 MAPKAPK2 NOS3 PIK3CB RAF1 STAT6 unknown CG mut

TP53 ATM EGFR NF1 BRAF SMARCA4 CTNNB1 TPR APOBEC3G MMP1 PTEN RB1 SMAD4 ATR BARD1 BLM FILIP1 SMAD2 ZMYND8 ALKBH1 ARAF CHEK1 E2F1 FER JAK1 MDM2 PAK1 PIK3R2 RALA TGFBR1 USP15 WEE1 AKT1 AR BACH1 BCL2 BID BMPR2 BRCA1 CCNB1IP1 CCND1 CDC25A CDC25B CDK4 CERK CHEK2 CHUK EDAR FOSL2 GSK3A HDAC1 HIPK2 JAKMIP1 LGALS13 MAX MSH2 MYC MYT1 NAB1 NFKB1 NOXA1 ODC1 PIAS1 PKIA PLK1 PML RAD51 RHEB RRAS SIRT1 SMAD1 STAT1 TAB1 TSC1 USP16 USP21 ZMIZ1


GRM1

GRM5

PRKCE

PRKCI GNAQ

GNB3

GNGT2

PRKCQ PRKCZ

RAF1

JAK2

JAK2

TCGA−17−Z022−01A−01W−0746−08 TCGA−05−4395−01A−01D−1265−08 TCGA−75−6211−01A−11D−1753−08 TCGA−64−1678−01A−01W−0928−08 TCGA−64−1676−01 TCGA−44−6778−01A−11D−1855−08 TCGA−75−5147−01A−01D−1625−08 TCGA−35−3621−01A−01D−0969−08 TCGA−05−5423−01A−01D−1625−08 27206 24617 TCGA−91−6836−01A−21D−1855−08 TCGA−64−1677−01A−01W−0928−08 TCGA−50−5932−01A−11D−1753−08 TCGA−49−6743−01A−11D−1855−08 TCGA−44−6774−01A−21D−1855−08 TCGA−05−4427−01A−21D−1855−08 TCGA−05−4389−01A−01D−1265−08 TCGA−50−5049−01A−01D−1625−08 TCGA−17−Z050−01A−01W−0747−08 TCGA−17−Z046−01A−01W−0746−08 TCGA−17−Z014−01A−01W−0746−08 TCGA−17−Z011−01A−01W−0746−08 TCGA−05−4397−01A−01D−1265−08 24637 24468 24320 TCGA−75−5146−01A−01D−1625−08 TCGA−50−6590−01A−12D−1855−08 TCGA−49−4514−01A−21D−1855−08 TCGA−05−4250−01A−01D−1105−08 27182 24252 24213 21472 21442 TCGA−38−4625−01A−01D−1553−08 TCGA−91−6829−01A−21D−1855−08 TCGA−73−4662−01A−01D−1265−08 TCGA−67−3771−01 TCGA−50−5072−01A−21D−1855−08 TCGA−17−Z049−01A−01W−0746−08 TCGA−17−Z015−01A−01W−0746−08 24177 21468

TCGA−75−5147−01A−01D−1625−08 TCGA−35−3621−01A−01D−0969−08 TCGA−05−5423−01A−01D−1625−08 27206 24617 TCGA−91−6836−01A−21D−1855−08 TCGA−64−1677−01A−01W−0928−08 TCGA−50−5932−01A−11D−1753−08 TCGA−49−6743−01A−11D−1855−08 TCGA−44−6774−01A−21D−1855−08 TCGA−05−4427−01A−21D−1855−08 TCGA−05−4389−01A−01D−1265−08 TCGA−05−4397−01A−01D−1265−08 TCGA−50−5049−01A−01D−1625−08 TCGA−17−Z050−01A−01W−0747−08 TCGA−17−Z046−01A−01W−0746−08 TCGA−17−Z014−01A−01W−0746−08 TCGA−17−Z011−01A−01W−0746−08 24637 24468 24320 TCGA−75−5146−01A−01D−1625−08 TCGA−50−6590−01A−12D−1855−08 TCGA−49−4514−01A−21D−1855−08 TCGA−05−4250−01A−01D−1105−08 27182 24252 24213 21472 21442 TCGA−91−6829−01A−21D−1855−08 TCGA−73−4662−01A−01D−1265−08 TCGA−67−3771−01 TCGA−50−5072−01A−21D−1855−08 TCGA−38−4625−01A−01D−1553−08 TCGA−17−Z049−01A−01W−0746−08 TCGA−17−Z015−01A−01W−0746−08 24177 21468

PI3K Events In ERBB4 Signaling FDR = 0.56%, FDR nod = 0.091% PI3K Events In ERBB2 Signaling FDR = 9.6e−12%, FDR nod = 0.18%

TCGA−44−6776−01A−11D−1855−08 TCGA−44−6775−01A−11D−1855−08 TCGA−49−4510−01A−01D−1265−08 TCGA−17−Z056−01A−01W−0747−08 TCGA−64−5781−01A−01D−1625−08 TCGA−50−5936−01A−11D−1625−08 TCGA−49−6744−01A−11D−1855−08 TCGA−35−5375−01A−01D−1625−08 TCGA−35−3621−01A−01D−0969−08 TCGA−17−Z062−01A−01W−0747−08 TCGA−49−6743−01A−11D−1855−08 TCGA−64−1677−01A−01W−0928−08 TCGA−50−6592−01A−11D−1753−08 TCGA−50−6590−01A−12D−1855−08 TCGA−50−5044−01A−21D−1855−08 TCGA−44−5645−01A−01D−1625−08 TCGA−44−2668−01 TCGA−05−4397−01A−01D−1265−08 TCGA−05−4249−01A−01D−1105−08 24617 TCGA−73−4668−01A−01D−1265−08 TCGA−44−5643−01A−01D−1625−08 TCGA−05−4424−01A−22D−1855−08 TCGA−05−4410−01A−21D−1855−08 TCGA−50−5935−01A−11D−1753−08 TCGA−50−5931−01A−11D−1753−08 TCGA−44−6145−01A−11D−1753−08 TCGA−44−2662−01 TCGA−35−4123−01A−01D−1105−08 TCGA−17−Z050−01A−01W−0747−08 TCGA−17−Z012−01A−01W−0746−08 TCGA−17−Z005−01A−01W−0746−08 TCGA−05−4398−01A−01D−1265−08 TCGA−91−6836−01A−21D−1855−08 TCGA−50−5049−01A−01D−1625−08 TCGA−44−4112−01 TCGA−17−Z022−01A−01W−0746−08 TCGA−05−4432−01A−01D−1265−08 TCGA−05−4427−01A−21D−1855−08 TCGA−05−4382−01A−01D−1265−08 TCGA−67−4679−01B−01D−1753−08 TCGA−67−3771−01 TCGA−64−5778−01A−01D−1625−08 TCGA−49−6767−01A−11D−1855−08 TCGA−44−6777−01A−11D−1855−08 TCGA−38−4631−01A−01D−1753−08 TCGA−17−Z055−01A−01W−0747−08 TCGA−17−Z028−01A−01W−0746−08 TCGA−17−Z021−01A−01W−0746−08 TCGA−17−Z010−01A−01W−0746−08 24667 24662 24245 24238 24191 24180 21454 21438

TCGA−44−6776−01A−11D−1855−08 TCGA−44−6775−01A−11D−1855−08 TCGA−67−3774−01 TCGA−05−4390−01A−02D−1753−08 TCGA−49−4510−01A−01D−1265−08 TCGA−17−Z056−01A−01W−0747−08 TCGA−73−4662−01A−01D−1265−08 TCGA−55−5899−01A−11D−1625−08 24269 TCGA−91−6829−01A−21D−1855−08 TCGA−75−5126−01A−01D−1753−08 TCGA−17−Z001−01A−01W−0746−08 TCGA−05−5429−01A−01D−1625−08 TCGA−64−5781−01A−01D−1625−08 TCGA−50−5936−01A−11D−1625−08 TCGA−49−6744−01A−11D−1855−08 TCGA−35−5375−01A−01D−1625−08 TCGA−17−Z062−01A−01W−0747−08 TCGA−35−3621−01A−01D−0969−08 TCGA−05−4434−01A−01D−1265−08 TCGA−86−6562−01A−11D−1753−08 TCGA−64−5815−01A−01D−1625−08 TCGA−44−2656−01 TCGA−17−Z049−01A−01W−0746−08 TCGA−05−4384−01A−01D−1753−08 21468 TCGA−49−6743−01A−11D−1855−08 TCGA−64−1677−01A−01W−0928−08 TCGA−50−6592−01A−11D−1753−08 TCGA−50−6590−01A−12D−1855−08 TCGA−50−5044−01A−21D−1855−08 TCGA−44−5645−01A−01D−1625−08 TCGA−44−2668−01 TCGA−05−4397−01A−01D−1265−08 TCGA−05−4249−01A−01D−1105−08 24617 TCGA−73−4668−01A−01D−1265−08 TCGA−44−5643−01A−01D−1625−08 TCGA−35−4123−01A−01D−1105−08 TCGA−17−Z012−01A−01W−0746−08 TCGA−05−4424−01A−22D−1855−08 TCGA−50−5935−01A−11D−1753−08 TCGA−50−5931−01A−11D−1753−08 TCGA−44−6145−01A−11D−1753−08 TCGA−44−2662−01 TCGA−17−Z050−01A−01W−0747−08 TCGA−17−Z005−01A−01W−0746−08 TCGA−05−4398−01A−01D−1265−08 TCGA−91−6836−01A−21D−1855−08 TCGA−50−5049−01A−01D−1625−08 TCGA−05−4432−01A−01D−1265−08 TCGA−64−5778−01A−01D−1625−08 TCGA−44−4112−01 TCGA−17−Z022−01A−01W−0746−08 TCGA−05−4427−01A−21D−1855−08 TCGA−67−4679−01B−01D−1753−08 TCGA−67−3771−01 TCGA−49−6767−01A−11D−1855−08 TCGA−44−6777−01A−11D−1855−08 TCGA−38−4631−01A−01D−1753−08 TCGA−17−Z055−01A−01W−0747−08 TCGA−17−Z028−01A−01W−0746−08 TCGA−17−Z021−01A−01W−0746−08 TCGA−17−Z010−01A−01W−0746−08 24667 24662 24245 24238 24191 24180 21454 21438 TCGA−05−4410−01A−21D−1855−08 TCGA−05−4382−01A−01D−1265−08 21472 TCGA−38−4629−01A−02D−1265−08 TCGA−17−Z026−01A−01W−0746−08 24177 TCGA−91−6835−01A−11D−1855−08 TCGA−75−6207−01A−11D−1753−08 TCGA−67−6217−01A−11D−1753−08 TCGA−67−3772−01A−01W−0928−08 TCGA−67−3770−01 TCGA−50−6595−01A−12D−1855−08 TCGA−50−6591−01A−11D−1753−08 TCGA−50−5944−01A−11D−1753−08 TCGA−49−4494−01A−01D−1265−08 TCGA−49−4490−01A−21D−1855−08 TCGA−44−6147−01A−11D−1753−08 TCGA−38−6178−01A−11D−1753−08 TCGA−38−4628−01A−01D−1265−08 TCGA−38−4627−01A−01D−1553−08 TCGA−17−Z047−01A−01W−0747−08 TCGA−17−Z035−01A−01W−0746−08 TCGA−17−Z032−01A−01W−0746−08 TCGA−05−5423−01A−01D−1625−08 27194 27186 24682 24678 24629 24626 24621 24331 24326 24302 24301 24296 24295 24231 24230 24218 24208 24200 24193

PIP3 Activates AKT Signaling FDR = 1.6e−10%, FDR nod = 1.4% PI3K/AKT Activation FDR = 5.5%, FDR nod = 0.23%

TCGA−17−Z045−01A−01W−0746−08 TCGA−44−3396−01A−01D−1265−08 TCGA−44−6776−01A−11D−1855−08 TCGA−05−4389−01A−01D−1265−08 TCGA−67−3773−01 TCGA−67−6216−01A−11D−1753−08 TCGA−17−Z030−01A−01W−0746−08 TCGA−49−4505−01A−01D−1265−08 TCGA−67−3774−01 24293 TCGA−55−1594−01 TCGA−55−6642−01A−11D−1855−08 TCGA−75−5146−01A−01D−1625−08 TCGA−44−2659−01 TCGA−50−5930−01A−11D−1753−08 TCGA−38−4626−01A−01D−1553−08 TCGA−44−6144−01A−11D−1753−08 TCGA−17−Z056−01A−01W−0747−08 TCGA−73−4677−01A−01D−1265−08 TCGA−75−5122−01A−01D−1753−08 24317 TCGA−05−4405−01A−21D−1855−08 24256 TCGA−44−6775−01A−11D−1855−08 27177 TCGA−80−5611−01A−01D−1625−08 TCGA−55−1592−01 TCGA−75−6211−01A−11D−1753−08 TCGA−05−4420−01A−01D−1265−08 TCGA−38−4625−01A−01D−1553−08 TCGA−05−5428−01A−01D−1625−08 27206 24581 TCGA−73−4676−01A−01D−1753−08 27182 TCGA−17−Z001−01A−01W−0746−08 TCGA−05−5429−01A−01D−1625−08 TCGA−73−4666−01A−01D−1265−08 TCGA−50−5072−01A−21D−1855−08 TCGA−91−6831−01A−11D−1855−08 TCGA−55−1596−01 TCGA−64−1678−01A−01W−0928−08 TCGA−17−Z011−01A−01W−0746−08 24637 24468 27193 24652 24250 TCGA−55−5899−01A−11D−1625−08 TCGA−73−4662−01A−01D−1265−08 24269 TCGA−44−6778−01A−11D−1855−08 TCGA−44−3918−01A−01D−1105−08 TCGA−17−Z043−01A−01W−0746−08 TCGA−50−5936−01A−11D−1625−08 TCGA−17−Z062−01A−01W−0747−08 TCGA−49−6744−01A−11D−1855−08 TCGA−35−5375−01A−01D−1625−08 TCGA−49−4506−01A−01D−1265−08 TCGA−49−4514−01A−21D−1855−08 TCGA−35−4122−01A−01D−1105−08 24683 TCGA−64−5775−01A−01D−1625−08 TCGA−49−4510−01A−01D−1265−08 TCGA−73−4670−01A−01D−1265−08 TCGA−50−6593−01A−11D−1753−08 TCGA−17−Z053−01A−01W−0747−08 TCGA−05−4417−01A−22D−1855−08 TCGA−73−4658−01A−01D−1753−08 24609 24598 24261 TCGA−50−6592−01A−11D−1753−08 TCGA−44−5645−01A−01D−1625−08 TCGA−05−4249−01A−01D−1105−08 TCGA−64−1677−01A−01W−0928−08 TCGA−50−5044−01A−21D−1855−08 TCGA−64−1676−01 TCGA−17−Z015−01A−01W−0746−08 TCGA−05−4244−01A−01D−1105−08 TCGA−67−6215−01A−11D−1753−08 TCGA−44−2655−01 TCGA−05−4418−01A−01D−1265−08 TCGA−05−4390−01A−02D−1753−08 TCGA−17−Z046−01A−01W−0746−08 24320 TCGA−44−2666−01 TCGA−05−4422−01A−01D−1265−08 24605 TCGA−44−2656−01 21468 TCGA−05−4434−01A−01D−1265−08 TCGA−05−4384−01A−01D−1753−08 TCGA−86−6562−01A−11D−1753−08 TCGA−64−5815−01A−01D−1625−08 TCGA−17−Z049−01A−01W−0746−08 TCGA−75−5126−01A−01D−1753−08 TCGA−91−6829−01A−21D−1855−08 TCGA−64−5781−01A−01D−1625−08 TCGA−50−6590−01A−12D−1855−08 TCGA−49−6743−01A−11D−1855−08 TCGA−44−3398−01A−01D−1105−08 TCGA−64−5779−01A−01D−1625−08 TCGA−49−4486−01A−01D−1265−08 TCGA−17−Z008−01A−01W−0746−08 TCGA−73−4668−01A−01D−1265−08 TCGA−35−4123−01A−01D−1105−08 TCGA−17−Z012−01A−01W−0746−08 TCGA−44−5643−01A−01D−1625−08 TCGA−17−Z050−01A−01W−0747−08 TCGA−05−4398−01A−01D−1265−08 TCGA−50−5931−01A−11D−1753−08 TCGA−44−6145−01A−11D−1753−08 TCGA−44−2662−01 TCGA−05−4424−01A−22D−1855−08 TCGA−50−5935−01A−11D−1753−08 TCGA−17−Z005−01A−01W−0746−08 TCGA−05−4397−01A−01D−1265−08 24617 TCGA−35−3621−01A−01D−0969−08 TCGA−44−2668−01 TCGA−38−4632−01A−01D−1753−08 24599 TCGA−75−5125−01A−01D−1753−08 TCGA−50−5066−01A−01D−1625−08 TCGA−17−Z014−01A−01W−0746−08 24181 TCGA−55−6712−01A−11D−1855−08 TCGA−17−Z023−01A−01W−0746−08 TCGA−17−Z003−01A−01W−0746−08 24276 21442 TCGA−17−Z022−01A−01W−0746−08 TCGA−91−6836−01A−21D−1855−08 TCGA−50−5049−01A−01D−1625−08 TCGA−05−4432−01A−01D−1265−08 TCGA−05−4427−01A−21D−1855−08 TCGA−67−3771−01 TCGA−49−6767−01A−11D−1855−08 TCGA−44−4112−01 TCGA−38−4631−01A−01D−1753−08 TCGA−17−Z055−01A−01W−0747−08 TCGA−17−Z021−01A−01W−0746−08 TCGA−67−4679−01B−01D−1753−08 TCGA−64−5778−01A−01D−1625−08 TCGA−44−6777−01A−11D−1855−08 TCGA−17−Z028−01A−01W−0746−08 24191 21438 TCGA−17−Z010−01A−01W−0746−08 24667 24662 24245 24238 24180 21454 21472 TCGA−17−Z026−01A−01W−0746−08 TCGA−05−4410−01A−21D−1855−08 TCGA−05−4382−01A−01D−1265−08 TCGA−17−Z032−01A−01W−0746−08 TCGA−67−3770−01 24177 TCGA−67−6217−01A−11D−1753−08 TCGA−50−6591−01A−11D−1753−08 TCGA−49−4494−01A−01D−1265−08 TCGA−44−6147−01A−11D−1753−08 TCGA−38−4629−01A−02D−1265−08 TCGA−91−6835−01A−11D−1855−08 TCGA−75−6207−01A−11D−1753−08 TCGA−67−3772−01A−01W−0928−08 TCGA−50−6595−01A−12D−1855−08 TCGA−50−5944−01A−11D−1753−08 TCGA−49−4490−01A−21D−1855−08 TCGA−38−6178−01A−11D−1753−08 TCGA−38−4628−01A−01D−1265−08 TCGA−38−4627−01A−01D−1553−08 TCGA−17−Z047−01A−01W−0747−08 TCGA−17−Z035−01A−01W−0746−08 TCGA−05−5423−01A−01D−1625−08 27194 27186 24682 24678 24629 24626 24621 24331 24326 24302 24301 24296 24295 24231 24230 24218 24208 24200 24193

TCGA−50−5051−01A−21D−1855−08 TCGA−05−4420−01A−01D−1265−08 TCGA−44−6775−01A−11D−1855−08 27177 TCGA−91−6836−01A−21D−1855−08 TCGA−44−6776−01A−11D−1855−08 TCGA−38−4625−01A−01D−1553−08 TCGA−05−5428−01A−01D−1625−08 TCGA−80−5611−01A−01D−1625−08 TCGA−73−4668−01A−01D−1265−08 TCGA−55−1592−01 TCGA−44−6778−01A−11D−1855−08 TCGA−05−4397−01A−01D−1265−08 TCGA−64−1677−01A−01W−0928−08 TCGA−50−6592−01A−11D−1753−08 TCGA−50−5044−01A−21D−1855−08 TCGA−44−5645−01A−01D−1625−08 TCGA−44−2668−01 TCGA−05−4249−01A−01D−1105−08 TCGA−50−6590−01A−12D−1855−08 TCGA−44−5643−01A−01D−1625−08 24617 TCGA−67−3771−01 TCGA−50−5049−01A−01D−1625−08 TCGA−49−6767−01A−11D−1855−08 TCGA−49−4514−01A−21D−1855−08 TCGA−49−4506−01A−01D−1265−08 TCGA−35−4122−01A−01D−1105−08 TCGA−05−4432−01A−01D−1265−08 24683 TCGA−49−6743−01A−11D−1855−08 21472 21468 TCGA−73−4659−01A−01D−1265−08 TCGA−67−3770−01 TCGA−49−4494−01A−01D−1265−08 TCGA−17−Z062−01A−01W−0747−08 TCGA−17−Z060−01A−01W−0747−08 TCGA−17−Z008−01A−01W−0746−08 TCGA−05−4424−01A−22D−1855−08 TCGA−05−4398−01A−01D−1265−08 24662 24625 24582 24481 24268

Signalling To P38 Via RIT And RIN FDR = 1e−09%, FDR nod = 1.1e−05% Prolactin FDR = 2e−12%, FDR nod = 0.00055%


BRAF


wt wt

BTC ERBB3

EREG BTC

NRG2 GAB1

NRG4 HBEGF

PIK3R1 PIK3R1

unknown CG mut NTRK1

RIT1

RIT2

NGF


PIK3CA

PIK3CB

wt wt

IRS2

PIK3R1

PIK3R2

NGF

RHOA

wt NTRK1 wt

TCGA−05−4420−01A−01D−1265−08 TCGA−49−6742−01A−11D−1855−08 TCGA−17−Z030−01A−01W−0746−08 TCGA−05−4427−01A−21D−1855−08 TCGA−91−6836−01A−21D−1855−08 TCGA−73−4666−01A−01D−1265−08 TCGA−55−1596−01 TCGA−49−4514−01A−21D−1855−08 TCGA−17−Z044−01A−01W−0746−08 TCGA−05−4384−01A−01D−1753−08 TCGA−73−4659−01A−01D−1265−08 TCGA−67−3770−01 TCGA−49−6743−01A−11D−1855−08 TCGA−49−4494−01A−01D−1265−08 TCGA−17−Z062−01A−01W−0747−08 TCGA−17−Z060−01A−01W−0747−08 TCGA−05−4424−01A−22D−1855−08 TCGA−05−4398−01A−01D−1265−08 24662 24625 24582 24481 21472 21468 TCGA−17−Z008−01A−01W−0746−08 TCGA−17−Z012−01A−01W−0746−08 24268 TCGA−75−5146−01A−01D−1625−08 TCGA−50−6594−01A−11D−1753−08 TCGA−50−5942−01A−21D−1753−08 TCGA−50−5941−01A−11D−1753−08 TCGA−50−5933−01A−11D−1753−08 TCGA−50−5044−01A−21D−1855−08 TCGA−44−6774−01A−21D−1855−08 TCGA−44−3918−01A−01D−1105−08 TCGA−44−2666−01 TCGA−44−2662−01 TCGA−05−5428−01A−01D−1625−08 TCGA−05−4410−01A−21D−1855−08 TCGA−05−4389−01A−01D−1265−08 TCGA−05−4382−01A−01D−1265−08 TCGA−05−4249−01A−01D−1105−08 27206 24666

TCGA−17−Z018−01A−01W−0746−08 24319 TCGA−75−5147−01A−01D−1625−08 24267 TCGA−44−2661−01A−01D−1105−08 TCGA−75−6206−01A−11D−1753−08 24681 TCGA−17−Z053−01A−01W−0747−08 TCGA−44−2655−01 TCGA−17−Z056−01A−01W−0747−08 27177 TCGA−44−6776−01A−11D−1855−08 TCGA−49−4512−01A−21D−1855−08 TCGA−49−6744−01A−11D−1855−08 TCGA−17−Z045−01A−01W−0746−08 TCGA−73−4676−01A−01D−1753−08 24600 TCGA−75−6211−01A−11D−1753−08 TCGA−49−4507−01A−01D−1265−08 24318 TCGA−67−3774−01 24181 TCGA−64−5774−01A−01D−1625−08 24317 TCGA−50−5045−01A−01D−1625−08 TCGA−38−4632−01A−01D−1753−08 21470 TCGA−44−6144−01A−11D−1753−08 TCGA−05−5429−01A−01D−1625−08 TCGA−17−Z040−01A−01W−0746−08 27193 TCGA−71−6725−01A−11D−1855−08 TCGA−35−4122−01A−01D−1105−08 TCGA−17−Z015−01A−01W−0746−08 TCGA−73−4662−01A−01D−1265−08 TCGA−64−5775−01A−01D−1625−08 24581 TCGA−50−5939−01A−11D−1625−08 TCGA−05−4426−01A−01D−1265−08 TCGA−17−Z025−01A−01W−0746−08 TCGA−17−Z052−01A−01W−0747−08 TCGA−17−Z017−01A−01W−0746−08 TCGA−44−2657−01A−01D−1105−08 TCGA−49−6742−01A−11D−1855−08 TCGA−17−Z000−01A−01W−0746−08 24604 TCGA−50−5068−01A−01D−1625−08 TCGA−49−6745−01A−11D−1855−08 TCGA−44−2665−01 TCGA−55−1594−01 TCGA−67−3773−01 TCGA−05−4403−01A−01D−1265−08 TCGA−05−4430−01A−02D−1265−08 24683 TCGA−17−Z013−01A−01W−0746−08 TCGA−49−4505−01A−01D−1265−08 TCGA−35−3615−01 TCGA−17−Z005−01A−01W−0746−08 24205 TCGA−55−1595−01A−01D−0969−08 27197 21451 TCGA−80−5611−01A−01D−1625−08 TCGA−44−6778−01A−11D−1855−08 TCGA−73−4668−01A−01D−1265−08 TCGA−55−1592−01 TCGA−44−2668−01 TCGA−44−5643−01A−01D−1625−08 TCGA−64−1677−01A−01W−0928−08 TCGA−44−5645−01A−01D−1625−08 TCGA−05−4418−01A−01D−1265−08 24256 TCGA−17−Z058−01A−01W−0747−08 24653 TCGA−64−1676−01 TCGA−50−5051−01A−21D−1855−08 TCGA−73−4670−01A−01D−1265−08 TCGA−73−4666−01A−01D−1265−08 TCGA−55−6712−01A−11D−1855−08 TCGA−05−4250−01A−01D−1105−08 TCGA−49−4514−01A−21D−1855−08 27182 24252 24213 21442 TCGA−38−4625−01A−01D−1553−08 TCGA−50−6592−01A−11D−1753−08 TCGA−49−4488−01A−01D−1753−08 TCGA−17−Z059−01A−01W−0747−08 TCGA−05−4390−01A−02D−1753−08 TCGA−50−5931−01A−11D−1753−08 TCGA−44−2656−01 21468 TCGA−86−6562−01A−11D−1753−08 TCGA−64−5815−01A−01D−1625−08 TCGA−05−4434−01A−01D−1265−08 TCGA−05−4384−01A−01D−1753−08 TCGA−17−Z046−01A−01W−0746−08 24320 TCGA−17−Z011−01A−01W−0746−08 TCGA−17−Z050−01A−01W−0747−08 TCGA−17−Z014−01A−01W−0746−08 24637 24468 TCGA−05−4405−01A−21D−1855−08 TCGA−50−5072−01A−21D−1855−08 TCGA−44−2659−01 TCGA−55−5899−01A−11D−1625−08 TCGA−05−4424−01A−22D−1855−08 TCGA−05−4398−01A−01D−1265−08 21452 TCGA−50−6590−01A−12D−1855−08 TCGA−49−6743−01A−11D−1855−08 TCGA−75−5126−01A−01D−1753−08 TCGA−64−5781−01A−01D−1625−08 TCGA−49−4486−01A−01D−1265−08 TCGA−35−4123−01A−01D−1105−08 TCGA−64−5779−01A−01D−1625−08 TCGA−44−6145−01A−11D−1753−08 TCGA−44−3398−01A−01D−1105−08 TCGA−35−3621−01A−01D−0969−08 24617 TCGA−64−1678−01A−01W−0928−08 TCGA−05−4417−01A−22D−1855−08 TCGA−49−4506−01A−01D−1265−08 TCGA−17−Z062−01A−01W−0747−08 TCGA−17−Z060−01A−01W−0747−08 TCGA−17−Z023−01A−01W−0746−08 24651 24625 TCGA−05−4397−01A−01D−1265−08 TCGA−91−6829−01A−21D−1855−08 TCGA−44−6775−01A−11D−1855−08 TCGA−17−Z049−01A−01W−0746−08 TCGA−17−Z042−01A−01W−0746−08 TCGA−91−6828−01A−11D−1855−08 TCGA−35−5375−01A−01D−1625−08 TCGA−17−Z057−01A−01W−0747−08 27210 TCGA−17−Z061−01A−01W−0747−08 TCGA−17−Z051−01A−01W−0747−08 TCGA−05−4415−01A−22D−1855−08 24276 24239 21462 TCGA−17−Z012−01A−01W−0746−08 TCGA−05−5428−01A−01D−1625−08 TCGA−05−4389−01A−01D−1265−08 TCGA−50−5941−01A−11D−1753−08 TCGA−50−5933−01A−11D−1753−08 TCGA−44−6774−01A−21D−1855−08 TCGA−44−3918−01A−01D−1105−08 TCGA−05−4249−01A−01D−1105−08 27206 TCGA−75−5146−01A−01D−1625−08 TCGA−50−6594−01A−11D−1753−08 TCGA−50−5044−01A−21D−1855−08 TCGA−44−2662−01 TCGA−17−Z008−01A−01W−0746−08 TCGA−50−5942−01A−21D−1753−08 TCGA−44−2666−01 24666 24268 TCGA−67−3771−01 TCGA−05−4427−01A−21D−1855−08 TCGA−91−6836−01A−21D−1855−08 TCGA−50−5049−01A−01D−1625−08 TCGA−17−Z022−01A−01W−0746−08 TCGA−05−4432−01A−01D−1265−08 TCGA−64−5778−01A−01D−1625−08 TCGA−44−4112−01 TCGA−17−Z028−01A−01W−0746−08 TCGA−49−6767−01A−11D−1855−08 TCGA−17−Z010−01A−01W−0746−08 24667 21454 21438 TCGA−67−4679−01B−01D−1753−08 TCGA−44−6777−01A−11D−1855−08 TCGA−38−4631−01A−01D−1753−08 TCGA−17−Z021−01A−01W−0746−08 24245 TCGA−17−Z055−01A−01W−0747−08 24662 24238 24191 24180 21472 TCGA−17−Z026−01A−01W−0746−08 TCGA−05−4382−01A−01D−1265−08 TCGA−05−4410−01A−21D−1855−08 24177 TCGA−91−6835−01A−11D−1855−08 TCGA−38−4629−01A−02D−1265−08 TCGA−67−3770−01 TCGA−49−4490−01A−21D−1855−08 TCGA−38−4628−01A−01D−1265−08 TCGA−17−Z032−01A−01W−0746−08 TCGA−05−5423−01A−01D−1625−08 24621 24331 TCGA−75−6207−01A−11D−1753−08 TCGA−67−6217−01A−11D−1753−08 TCGA−67−3772−01A−01W−0928−08 TCGA−50−6595−01A−12D−1855−08 TCGA−50−6591−01A−11D−1753−08 TCGA−50−5944−01A−11D−1753−08 TCGA−49−4494−01A−01D−1265−08 TCGA−44−6147−01A−11D−1753−08 TCGA−38−6178−01A−11D−1753−08 TCGA−38−4627−01A−01D−1553−08 TCGA−17−Z047−01A−01W−0747−08 TCGA−17−Z035−01A−01W−0746−08 27194 27186 24682 24678 24629 24626 24326 24302 24301 24296 24295 24231 24230 24218 24208 24200 24193

EGFR ERBB4 BRAF RB1 PIK3CG MTOR PRKCB PTPN11 ERBB2 FLNA JAK2 BTRC FOXO3 PIK3CA PIK3CB TEC ITGB1 MAPK7 SH2B1 SOS1 STAT3 CBL CENPJ CREBBP FYN JAK1 LYN PTK2 STAT1 ZAP70 AGAP2 AKT1 EP300 FOS GRB2 GSK3B IGBP1 MAP2K1 MYC NFKB1 NFKBIA PAK1 PIAS3 PIK3R1 PIK3R2 PPP2CA PRLR RPS6KA2 SHC1 SLC12A2 STAT5A STAT5B TYK2 VAV2 CCND1 CTSD ELK1 ESR1 GAB2 HLTF IRS1 IRS2 JUN KHDRBS1 MAP2K2 MAPK14 MAPK4 MAPK8 MAPK9 MYB NCK1 NEK3 PLAU PPIB PRKCD PRL PTPN6 PXN RAF1 RELA RPS6KB1 SERPINE1 SIRPA SOCS2 SRC THRB VAV1 YWHAG

NRG1 NRG1

unknown CG mut EGFR ERBB4 PDGFRA NRG3 MTOR ERBB2 PDGFRB TNRC6A PIK3CA PTEN RICTOR IRS1 NRG1 CD86 ERBB3 FGFR4 PTPN11 TNRC6C AGO2 EGF FGFR2 FYN IRS2 LCK PIK3CB PIK3R2 VAV1 AKT1 AKT2 AKT3 BTC CD19 CD28 CD80 FGF10 FGF19 FGF4 FGF9 FGFR1 GRB2 KL KLB MLST8 MOV10 PDGFA PIK3R1 TNRC6B AGO1 AGO3 AGO4 EREG FGF1 FGF18 FGF20 FGF23 FGF3 FGF5 FGFR3 FRS2 GAB1 HBEGF KIT MAPKAP1 NRG2 NRG4 PDGFB PIK3CD PIK3R3 PRR5 THEM4 TRAT1 TRIB3 IRS1

ERBB4 EGFR

known HCG mut NRG3 known HCG mut NRG3


ERBB4

PIK3CA

PIK3CA ERBB2

EGF

EREG

GRB2

NRG2

HBEGF

NRG4

known HCG mut

JAK1

STAT3

unknown CG mut

TYK2

TCGA−17−Z055−01A−01W−0747−08 TCGA−49−6744−01A−11D−1855−08 TCGA−05−4427−01A−21D−1855−08 TCGA−49−4514−01A−21D−1855−08 TCGA−50−5049−01A−01D−1625−08 TCGA−44−6776−01A−11D−1855−08 TCGA−91−6831−01A−11D−1855−08 TCGA−49−4506−01A−01D−1265−08 TCGA−17−Z046−01A−01W−0746−08 TCGA−38−4632−01A−01D−1753−08 TCGA−50−5933−01A−11D−1753−08 TCGA−17−Z017−01A−01W−0746−08 TCGA−44−6774−01A−21D−1855−08 TCGA−44−2659−01 TCGA−05−4424−01A−22D−1855−08 TCGA−55−1596−01 TCGA−49−6745−01A−11D−1855−08 TCGA−44−2656−01 TCGA−44−6778−01A−11D−1855−08 TCGA−17−Z043−01A−01W−0746−08 TCGA−05−4420−01A−01D−1265−08 TCGA−05−4410−01A−21D−1855−08 TCGA−17−Z052−01A−01W−0747−08 TCGA−17−Z021−01A−01W−0746−08 TCGA−17−Z022−01A−01W−0746−08 TCGA−44−6144−01A−11D−1753−08 TCGA−44−4112−01 TCGA−05−5429−01A−01D−1625−08 TCGA−75−5147−01A−01D−1625−08 TCGA−35−3621−01A−01D−0969−08 TCGA−05−5423−01A−01D−1625−08 27206 24617 TCGA−91−6836−01A−21D−1855−08 TCGA−73−4668−01A−01D−1265−08 TCGA−44−2662−01 TCGA−17−Z012−01A−01W−0746−08 21454 TCGA−05−4397−01A−01D−1265−08 TCGA−91−6835−01A−11D−1855−08 TCGA−64−1678−01A−01W−0928−08 TCGA−49−6742−01A−11D−1855−08 TCGA−17−Z042−01A−01W−0746−08 TCGA−17−Z028−01A−01W−0746−08 TCGA−17−Z000−01A−01W−0746−08 24604 TCGA−67−3771−01 TCGA−38−4625−01A−01D−1553−08 TCGA−91−6829−01A−21D−1855−08 TCGA−73−4662−01A−01D−1265−08 TCGA−50−5072−01A−21D−1855−08 TCGA−17−Z049−01A−01W−0746−08 TCGA−17−Z015−01A−01W−0746−08 24177 21468

TCGA−49−6744−01A−11D−1855−08 TCGA−17−Z051−01A−01W−0747−08 TCGA−55−1594−01 TCGA−55−1595−01A−01D−0969−08 24317 TCGA−80−5611−01A−01D−1625−08 TCGA−67−6215−01A−11D−1753−08 24177 TCGA−05−4427−01A−21D−1855−08 TCGA−49−4490−01A−21D−1855−08 TCGA−17−Z040−01A−01W−0746−08 TCGA−49−4507−01A−01D−1265−08 TCGA−17−Z055−01A−01W−0747−08 TCGA−05−4390−01A−02D−1753−08 24663 TCGA−73−4659−01A−01D−1265−08 TCGA−44−2656−01 TCGA−17−Z030−01A−01W−0746−08 TCGA−73−4662−01A−01D−1265−08 TCGA−38−4630−01A−01D−1265−08 TCGA−05−4432−01A−01D−1265−08 27177 24599 TCGA−17−Z026−01A−01W−0746−08 TCGA−73−4677−01A−01D−1265−08 TCGA−17−Z015−01A−01W−0746−08 TCGA−17−Z005−01A−01W−0746−08 TCGA−44−6778−01A−11D−1855−08 TCGA−75−6211−01A−11D−1753−08 TCGA−38−4625−01A−01D−1553−08 21472 TCGA−50−5935−01A−11D−1753−08 TCGA−44−2657−01A−01D−1105−08 TCGA−50−5051−01A−21D−1855−08 TCGA−75−5126−01A−01D−1753−08 TCGA−44−6147−01A−11D−1753−08 TCGA−35−3615−01 TCGA−17−Z014−01A−01W−0746−08 TCGA−17−Z020−01A−01W−0746−08 24209 21438 TCGA−71−6725−01A−11D−1855−08 TCGA−64−1680−01 TCGA−05−4250−01A−01D−1105−08 24692 21462 TCGA−73−4676−01A−01D−1753−08 TCGA−17−Z049−01A−01W−0746−08 27173 24252 TCGA−55−5899−01A−11D−1625−08 TCGA−05−4398−01A−01D−1265−08 TCGA−50−5072−01A−21D−1855−08 TCGA−05−4405−01A−21D−1855−08 24621 TCGA−55−1592−01 TCGA−44−6775−01A−11D−1855−08 TCGA−91−6835−01A−11D−1855−08 TCGA−49−4494−01A−01D−1265−08 TCGA−05−4418−01A−01D−1265−08 TCGA−64−1676−01 TCGA−49−6767−01A−11D−1855−08 21458 TCGA−05−4402−01A−01D−1265−08 TCGA−05−4395−01A−01D−1265−08 TCGA−05−4420−01A−01D−1265−08 TCGA−44−3396−01A−01D−1265−08 TCGA−17−Z042−01A−01W−0746−08 TCGA−17−Z025−01A−01W−0746−08 24694 TCGA−49−6743−01A−11D−1855−08 TCGA−44−5643−01A−01D−1625−08 TCGA−44−2668−01 TCGA−64−1677−01A−01W−0928−08 TCGA−50−6592−01A−11D−1753−08 TCGA−44−5645−01A−01D−1625−08 TCGA−91−6836−01A−21D−1855−08 TCGA−73−4670−01A−01D−1265−08 TCGA−50−5936−01A−11D−1625−08 TCGA−17−Z053−01A−01W−0747−08 TCGA−17−Z000−01A−01W−0746−08 24481 TCGA−38−4632−01A−01D−1753−08 TCGA−17−Z046−01A−01W−0746−08 TCGA−17−Z018−01A−01W−0746−08 27193 24320 TCGA−35−4123−01A−01D−1105−08 24280 TCGA−67−3771−01 TCGA−44−6777−01A−11D−1855−08 TCGA−35−5375−01A−01D−1625−08 TCGA−17−Z045−01A−01W−0746−08 24319 TCGA−64−5779−01A−01D−1625−08 24291 24256 24181 TCGA−05−4397−01A−01D−1265−08 24617 TCGA−64−1678−01A−01W−0928−08 TCGA−17−Z028−01A−01W−0746−08 21454 TCGA−17−Z062−01A−01W−0747−08 TCGA−17−Z023−01A−01W−0746−08 TCGA−05−4417−01A−22D−1855−08 TCGA−49−4506−01A−01D−1265−08 TCGA−35−3621−01A−01D−0969−08 TCGA−17−Z060−01A−01W−0747−08 24651 24625 TCGA−50−5933−01A−11D−1753−08 TCGA−05−5428−01A−01D−1625−08 TCGA−05−4410−01A−21D−1855−08 TCGA−05−4389−01A−01D−1265−08 TCGA−50−5941−01A−11D−1753−08 TCGA−50−5044−01A−21D−1855−08 TCGA−44−3918−01A−01D−1105−08 TCGA−05−4249−01A−01D−1105−08 27206 24666 TCGA−75−5146−01A−01D−1625−08 TCGA−50−5942−01A−21D−1753−08 TCGA−44−6774−01A−21D−1855−08 TCGA−44−2666−01 TCGA−44−2662−01 TCGA−17−Z012−01A−01W−0746−08 TCGA−17−Z008−01A−01W−0746−08 24268 TCGA−64−5781−01A−01D−1625−08 TCGA−17−Z022−01A−01W−0746−08 TCGA−05−4382−01A−01D−1265−08 TCGA−73−4668−01A−01D−1265−08 TCGA−64−5775−01A−01D−1625−08 TCGA−50−6594−01A−11D−1753−08 TCGA−50−6590−01A−12D−1855−08 TCGA−50−5049−01A−01D−1625−08 TCGA−38−4631−01A−01D−1753−08 TCGA−17−Z056−01A−01W−0747−08 TCGA−17−Z017−01A−01W−0746−08 TCGA−05−4424−01A−22D−1855−08 21452 TCGA−73−4666−01A−01D−1265−08 TCGA−50−5066−01A−01D−1625−08 TCGA−44−6776−01A−11D−1855−08 TCGA−44−2659−01 TCGA−05−4430−01A−02D−1265−08 TCGA−05−4384−01A−01D−1753−08 27210 TCGA−67−3773−01 TCGA−64−5778−01A−01D−1625−08 TCGA−44−4112−01 TCGA−38−4626−01A−01D−1553−08 TCGA−17−Z057−01A−01W−0747−08 27180 24667 24633 24203 21468

IL 6 Type Cytokine Receptor Ligand Interactions FDR = 0.74%, FDR nod = 1.4% IFN Gamma Signaling Pathway(JAK1 JAK2 STAT1) ( IFN Gamma Signaling(JAK1 JAK2 STAT1) ) FDR = 0.88%, FDR nod = 1.8%

TCGA−38−4631−01A−01D−1753−08 TCGA−50−5044−01A−21D−1855−08 TCGA−17−Z040−01A−01W−0746−08 TCGA−05−4432−01A−01D−1265−08 TCGA−35−4123−01A−01D−1105−08 TCGA−64−5778−01A−01D−1625−08 TCGA−05−4390−01A−02D−1753−08 TCGA−50−5936−01A−11D−1625−08 TCGA−05−4410−01A−21D−1855−08 TCGA−50−5933−01A−11D−1753−08 TCGA−17−Z014−01A−01W−0746−08 TCGA−75−5126−01A−01D−1753−08 TCGA−49−4488−01A−01D−1753−08 TCGA−44−2668−01 TCGA−91−6828−01A−11D−1855−08 TCGA−75−5122−01A−01D−1753−08 TCGA−71−6725−01A−11D−1855−08 TCGA−17−Z030−01A−01W−0746−08 TCGA−05−4398−01A−01D−1265−08 TCGA−64−1676−01 TCGA−17−Z026−01A−01W−0746−08 TCGA−17−Z005−01A−01W−0746−08 TCGA−75−5147−01A−01D−1625−08 TCGA−35−3621−01A−01D−0969−08 TCGA−05−5423−01A−01D−1625−08 27206 24617 TCGA−50−6590−01A−12D−1855−08 TCGA−75−5146−01A−01D−1625−08 TCGA−49−4514−01A−21D−1855−08 27182 24252 24213 21472 21442 TCGA−91−6829−01A−21D−1855−08 TCGA−73−4662−01A−01D−1265−08 TCGA−67−3771−01 TCGA−50−5072−01A−21D−1855−08 TCGA−17−Z049−01A−01W−0746−08 TCGA−17−Z015−01A−01W−0746−08 24177 21468 TCGA−64−5781−01A−01D−1625−08 TCGA−38−4625−01A−01D−1553−08 TCGA−05−4250−01A−01D−1105−08 TCGA−91−6836−01A−21D−1855−08 TCGA−49−6743−01A−11D−1855−08 TCGA−49−4486−01A−01D−1265−08 TCGA−44−2659−01 TCGA−17−Z017−01A−01W−0746−08 TCGA−05−5428−01A−01D−1625−08 TCGA−05−4424−01A−22D−1855−08

TCGA−44−2655−01 TCGA−50−5931−01A−11D−1753−08 TCGA−17−Z016−01A−01W−0746−08 TCGA−75−5122−01A−01D−1753−08 TCGA−55−1596−01 TCGA−05−4420−01A−01D−1265−08 TCGA−44−6144−01A−11D−1753−08 TCGA−44−4112−01 TCGA−17−Z022−01A−01W−0746−08 TCGA−05−5429−01A−01D−1625−08 TCGA−75−5146−01A−01D−1625−08 TCGA−50−6590−01A−12D−1855−08 TCGA−49−4514−01A−21D−1855−08 TCGA−05−4250−01A−01D−1105−08 27182 24252 24213 21472 21442 TCGA−91−6829−01A−21D−1855−08 TCGA−73−4662−01A−01D−1265−08 TCGA−67−3771−01 TCGA−50−5072−01A−21D−1855−08 TCGA−38−4625−01A−01D−1553−08 TCGA−17−Z049−01A−01W−0746−08 TCGA−17−Z015−01A−01W−0746−08 24177 21468

Regulation Of IFNA Signaling FDR = 0.0013%, FDR nod = 0.019% IRF3 Mediated Induction Of Type I IFN FDR = 0.02%, FDR nod = 0.074%


JAK1 JAK1

TYK2 JAK2

CRLF1 STAT1

LIF IFNG

CNTFR IFNGR2

IL27RA IFNGR1


JAK1 PRKDC

STAT2 NLRP4

IFNB1 IFI16

STAT1 MRE11A

IFNA16 XRCC5

PTPN6

DDX41

IFNA2

IFNA4

DTX4

IFNA14

TBK1

IFNA7

IFNA21

TMEM173

IFNA17

IFNA5

XRCC6

IFNAR2

TREX1

IFNA6

USP18

ZBP1

IFNA8

wt IFNA10 wt

known HCG mut TYK2 known HCG mut

wt IL27 wt

known HCG mut JAK2 known HCG mut

wt IFNA16

known HCG mut

wt

STAT2

STAT1

IFNA10

IFNA2

IFNA7

IFNA14

IFNA17 IFNA4

IFNA6

IFNA21 IFNA5

IFNAR2 IFNA8 IRF9

KDR BRAF PIK3CG PRKCG NRAS ETS1 PIK3CA PIK3C3 PLCG1 PRKCA PRKCB PRKCE PIK3C2B PRKD3 SH2D2A ARAF MAP2K1 PIK3C2A PIK3CD PLA2G4A PRKD1 PRKCH PRKD2 PTK2 RAF1 SPHK2 AKT1 HSPB1 PIK3R3 RAC2 CASP9 HIF1A HRAS MAP2K2 MAPK14 MAPKAPK2 MAPKAPK3 NOS3 PIK3CB PIK3R1 PIK3R2 PLCG2 PRKCD PRKCI PRKCQ PRKCZ PXN SHC2

unknown CG mut


VEGF Signaling Pathway FDR = 9e−06%, FDR nod = 0.14%

IL12RB2

OSMR

EBI3

OSM

CNTF

IL12A

LIFR

PTPN11

TCGA−17−Z056−01A−01W−0747−08 TCGA−49−6744−01A−11D−1855−08 TCGA−44−6776−01A−11D−1855−08 TCGA−05−4427−01A−21D−1855−08 TCGA−49−4514−01A−21D−1855−08 TCGA−38−4632−01A−01D−1753−08 TCGA−17−Z017−01A−01W−0746−08 TCGA−44−6774−01A−21D−1855−08 TCGA−44−2659−01 TCGA−91−6831−01A−11D−1855−08 TCGA−49−4506−01A−01D−1265−08 TCGA−50−5933−01A−11D−1753−08 TCGA−44−5643−01A−01D−1625−08 TCGA−38−4628−01A−01D−1265−08 TCGA−55−1596−01 TCGA−49−6745−01A−11D−1855−08 TCGA−44−2656−01 TCGA−44−6778−01A−11D−1855−08 TCGA−17−Z043−01A−01W−0746−08 TCGA−05−4420−01A−01D−1265−08 TCGA−05−4410−01A−21D−1855−08 TCGA−17−Z052−01A−01W−0747−08 TCGA−17−Z021−01A−01W−0746−08 TCGA−17−Z022−01A−01W−0746−08 TCGA−44−6144−01A−11D−1753−08 TCGA−44−4112−01 TCGA−05−5429−01A−01D−1625−08 TCGA−05−4424−01A−22D−1855−08 TCGA−50−6592−01A−11D−1753−08 TCGA−05−4417−01A−22D−1855−08 TCGA−05−4398−01A−01D−1265−08 TCGA−75−5147−01A−01D−1625−08 TCGA−35−3621−01A−01D−0969−08 TCGA−05−5423−01A−01D−1625−08 27206 24617 TCGA−91−6836−01A−21D−1855−08 TCGA−73−4668−01A−01D−1265−08 TCGA−44−2662−01 TCGA−17−Z012−01A−01W−0746−08 21454 TCGA−17−Z046−01A−01W−0746−08 TCGA−05−4397−01A−01D−1265−08 TCGA−50−5049−01A−01D−1625−08 TCGA−17−Z050−01A−01W−0747−08 TCGA−17−Z014−01A−01W−0746−08 TCGA−17−Z011−01A−01W−0746−08 24637 24468 24320 TCGA−38−4625−01A−01D−1553−08 TCGA−91−6829−01A−21D−1855−08 TCGA−73−4662−01A−01D−1265−08 TCGA−67−3771−01 TCGA−50−5072−01A−21D−1855−08 TCGA−17−Z049−01A−01W−0746−08 TCGA−17−Z015−01A−01W−0746−08 24177 21468

TCGA−17−Z023−01A−01W−0746−08 TCGA−75−5125−01A−01D−1753−08 TCGA−73−4675−01A−01D−1265−08 TCGA−49−6767−01A−11D−1855−08 TCGA−38−4632−01A−01D−1753−08 TCGA−50−5049−01A−01D−1625−08 TCGA−64−5781−01A−01D−1625−08 TCGA−67−3772−01A−01W−0928−08 TCGA−49−4488−01A−01D−1753−08 TCGA−17−Z046−01A−01W−0746−08 TCGA−05−5715−01A−01D−1625−08 TCGA−17−Z026−01A−01W−0746−08 TCGA−50−5045−01A−01D−1625−08 TCGA−44−3398−01A−01D−1105−08 TCGA−17−Z049−01A−01W−0746−08 TCGA−17−Z045−01A−01W−0746−08 TCGA−67−3771−01 TCGA−64−5778−01A−01D−1625−08 TCGA−44−3918−01A−01D−1105−08 TCGA−44−2668−01 TCGA−17−Z003−01A−01W−0746−08 TCGA−05−4405−01A−21D−1855−08 TCGA−73−4666−01A−01D−1265−08 TCGA−17−Z022−01A−01W−0746−08 TCGA−64−1676−01 TCGA−55−1595−01A−01D−0969−08 TCGA−50−5944−01A−11D−1753−08 TCGA−50−5051−01A−21D−1855−08 TCGA−49−4514−01A−21D−1855−08 TCGA−49−4494−01A−01D−1265−08 TCGA−44−3919−01 TCGA−44−2656−01 TCGA−17−Z042−01A−01W−0746−08 TCGA−05−4424−01A−22D−1855−08 TCGA−05−4410−01A−21D−1855−08 TCGA−64−1678−01A−01W−0928−08 TCGA−91−6829−01A−21D−1855−08 TCGA−17−Z055−01A−01W−0747−08 TCGA−05−4382−01A−01D−1265−08 TCGA−75−5126−01A−01D−1753−08 TCGA−73−4677−01A−01D−1265−08 TCGA−73−4659−01A−01D−1265−08 TCGA−73−4658−01A−01D−1753−08 TCGA−64−5779−01A−01D−1625−08 TCGA−49−6742−01A−11D−1855−08 TCGA−44−4112−01 TCGA−44−2661−01A−01D−1105−08 TCGA−38−6178−01A−11D−1753−08 TCGA−17−Z056−01A−01W−0747−08 TCGA−17−Z028−01A−01W−0746−08 TCGA−17−Z021−01A−01W−0746−08 TCGA−17−Z004−01A−01W−0746−08 TCGA−05−5428−01A−01D−1625−08 TCGA−05−4397−01A−01D−1265−08 TCGA−05−4250−01A−01D−1105−08 24617 24581 24486 24256 24238 24177 21472

PRAD

Packaging Of Telomere Ends FDR = 0.066%, FDR nod = 1% DNA Damage/Telomere Stress Induced Senescence FDR = 6.7e−09%, FDR nod = 3.9%

HIST2H2BE

HIST3H3

CCNE2

HIST1H2BE

HIST1H2BH

NBN

TERF2IP

TCGA−KK−A5A1

HIST2H2AC

TCGA−CH−5746

HIST1H4K

TCGA−CH−5768

HIST1H2BG

TCGA−KK−A59X

HIST1H2BF

TCGA−CH−5794

CDKN1A

TCGA−CH−5737

wt

TCGA−KC−A4BR

CCNA1

TCGA−KK−A6E5

HIST1H2BN

TCGA−HC−8216

HIST1H2BK

TCGA−HC−7750

unknown CG mut

TCGA−HC−7745

ATM

TCGA−EJ−7317

TP53

TCGA−CH−5738

DNA Damage/Telomere Stress Induced Senescence FDR = 6.7e−09%, FDR nod = 3.9%

TCGA−G9−6385 TCGA−FC−A66V

TCGA−KK−A5A1 TCGA−CH−5746 TCGA−CH−5768 TCGA−KK−A59X TCGA−CH−5794 TCGA−KC−A4BR TCGA−KK−A6E5 TCGA−HC−A6AP TCGA−CH−5745 TCGA−HC−7750 TCGA−HC−7745 TCGA−EJ−7317 TCGA−CH−5738 TCGA−G9−6385 TCGA−FC−A66V TCGA−CH−5752 TCGA−EJ−7786 TCGA−EJ−5518 TCGA−CH−5737 TCGA−J4−A67Q TCGA−HC−A4ZV TCGA−HC−8260 TCGA−EJ−7784 TCGA−EJ−7783 TCGA−EJ−5511 TCGA−CH−5762 TCGA−HC−8216 TCGA−G9−7521 TCGA−G9−7510 TCGA−EJ−5525 TCGA−EJ−5507 TCGA−KK−A6DY TCGA−J9−A52B TCGA−J4−A67L TCGA−HI−7171 TCGA−HC−A632 TCGA−HC−A631 TCGA−HC−8264 TCGA−HC−7742 TCGA−HC−7230 TCGA−HC−7213 TCGA−G9−6499 TCGA−EJ−7781 TCGA−EJ−7315 TCGA−EJ−5521 TCGA−EJ−5514 TCGA−CH−5761

HIST1H4B

known HCG mut CDKN1B

HIST1H2BK TP53

HIST1H2BE HIST1H4B CCNA1

wt wt

CDKN1A

HIST1H2BG HIST1H2BF

HIST1H2BF

HIST1H2BG

HIST1H2BH HIST1H4K

HIST2H2AC HIST2H2BE

HIST1H4K

HIST2H2AC HIST3H3 CCNE2

HIST1H2BE

HIST2H2BE

HIST3H3 HIST1H2BH NBN

TERF2IP TERF2IP

known HCG mut HIST1H2BN known HCG mut CDKN1B


ATM

HIST1H2BK

HIST1H4B HIST1H2BN

TCGA−KK−A5A1 TCGA−CH−5746 TCGA−CH−5768 TCGA−KK−A59X TCGA−CH−5794 TCGA−KC−A4BR TCGA−KK−A6E5 TCGA−HC−A6AP TCGA−CH−5745 TCGA−HC−7750 TCGA−HC−7745 TCGA−EJ−7317 TCGA−CH−5738 TCGA−G9−6385 TCGA−FC−A66V TCGA−CH−5752 TCGA−EJ−7786 TCGA−EJ−5518 TCGA−CH−5737 TCGA−J4−A67Q TCGA−HC−A4ZV TCGA−HC−8260 TCGA−EJ−7784 TCGA−EJ−7783 TCGA−EJ−5511 TCGA−CH−5762 TCGA−HC−8216 TCGA−G9−7521 TCGA−G9−7510 TCGA−EJ−5525 TCGA−EJ−5507 TCGA−KK−A6DY TCGA−J9−A52B TCGA−J4−A67L TCGA−HI−7171 TCGA−HC−A632 TCGA−HC−A631 TCGA−HC−8264 TCGA−HC−7742 TCGA−HC−7230 TCGA−HC−7213 TCGA−G9−6499 TCGA−EJ−7781 TCGA−EJ−7315 TCGA−EJ−5521 TCGA−EJ−5514 TCGA−CH−5761

SKCM

IRF3 Mediated Activation Of Type 1 IFN FDR = 1.2e−06%, FDR nod = 1.2e−05% Activation Of Matrix Metalloproteinases FDR = 0.022%, FDR nod = 0.093%

wt wt COL18A1


unknown CG mut PLG

unknown CG mut PRSS1

NLRP4 KLKB1

MMP15

MMP10 MMP3

DTX4 MMP24

MMP16

MMP25 CMA1

ZBP1 FURIN MMP8

MMP9 CTSG

TBK1 CTSV

MMP11

MMP17 MMP2

MMP7

IRF3 TIMP2

TPSAB1 CTRB1 CTSK

ELANE

TMEM173 KLK2

MMP14 TIMP1

TCGA−EE−A3AA ME017−Tumor TCGA−EE−A2GN TCGA−BF−A1PV TCGA−ER−A19P TCGA−EE−A2MS TCGA−EE−A20H TCGA−GN−A267 TCGA−FS−A1Z3 TCGA−ER−A19G TCGA−EE−A2MN TCGA−DA−A1HY SKCM−UKRV−Mel−24−Tumor SKCM−Ma−Mel−48−Tumor TCGA−FS−A1ZK TCGA−D9−A1JX SKCM−Ma−Mel−114−Tumor SKCM−Ma−Mel−08a−Tumor SKCM−JWCI−WGS−43−Tumor SKCM−JWCI−WGS−42−Tumor SKCM−13543−Tumor TCGA−ER−A193 TCGA−EE−A2M5 TCGA−EE−A29V TCGA−EE−A182 TCGA−D3−A3C8 SKCM−Ma−Mel−85−Tumor SKCM−Ma−Mel−65−Tumor SKCM−JWCI−WGS−12−Tumor SKCM−JWCI−WGS−1−Tumor TCGA−GN−A26C TCGA−GN−A269 TCGA−FS−A1ZZ TCGA−FS−A1ZW TCGA−FS−A1ZP TCGA−FS−A1YY TCGA−ER−A2ND TCGA−ER−A2NC TCGA−ER−A19K TCGA−ER−A19D TCGA−ER−A19A TCGA−EE−A3AG TCGA−EE−A3AE TCGA−EE−A2MJ TCGA−EE−A2MI TCGA−EE−A2MF TCGA−EE−A2GT TCGA−EE−A2GR TCGA−EE−A2GO TCGA−EE−A2GJ TCGA−EE−A2GB TCGA−EE−A29T TCGA−EE−A29Q TCGA−EE−A29M TCGA−EE−A29L TCGA−EE−A183 TCGA−EE−A181 TCGA−EB−A24D TCGA−DA−A1IC TCGA−DA−A1I5 TCGA−DA−A1I0 TCGA−DA−A1HV TCGA−D9−A148 TCGA−D3−A3CB TCGA−D3−A2JA SKCM−Ma−Mel−92−Tumor SKCM−Ma−Mel−36−Tumor SKCM−Ma−Mel−119−Tumor SKCM−JWCI−WGS−32−Tumor SKCM−JWCI−WGS−22−Tumor SKCM−JWCI−WGS−13−Tumor SKCM−JWCI−14−Tumor ME032−Tumor ME024−Tumor ME014−Tumor

TCGA−EE−A2M6 SKCM−13600−Tumor ME049−Tumor SKCM−JWCI−WGS−33−Tumor SKCM−13561−Tumor TCGA−D3−A1Q4 TCGA−BF−A3DL TCGA−EE−A3AD SKCM−JWCI−27−Tumor TCGA−FS−A1ZJ TCGA−EB−A24D TCGA−ER−A3ES TCGA−DA−A1I0 TCGA−ER−A2NE TCGA−D3−A3MR TCGA−DA−A3F8 SKCM−JWCI−WGS−32−Tumor TCGA−ER−A2NB TCGA−EE−A29V SKCM−Ma−Mel−04−Tumor TCGA−D3−A2JN SKCM−Ma−Mel−123−Tumor SKCM−JWCI−WGS−4−Tumor TCGA−EE−A184 SKCM−JWCI−WGS−13−Tumor ME011−Tumor SKCM−Ma−Mel−92−Tumor TCGA−GN−A264 TCGA−D3−A3ML TCGA−FS−A1ZW TCGA−EE−A2GP TCGA−EE−A29P TCGA−DA−A3F3 SKCM−JWCI−WGS−11−Tumor TCGA−GN−A263 TCGA−EE−A2MS TCGA−EE−A2MC TCGA−DA−A1HY SKCM−Ma−Mel−37−Tumor TCGA−ER−A2NG TCGA−ER−A19N TCGA−ER−A195 TCGA−EE−A29N SKCM−JWCI−WGS−5−Tumor TCGA−FS−A1ZK TCGA−EE−A3J3 TCGA−EE−A2GC TCGA−DA−A1I1 ME034−Tumor ME018−Tumor TCGA−DA−A1HV TCGA−ER−A19P TCGA−D3−A1QA TCGA−ER−A194 TCGA−DA−A1I5 TCGA−D3−A3C8 SKCM−Ma−Mel−55−Tumor SKCM−JWCI−WGS−35−Tumor SKCM−Ma−Mel−114−Tumor TCGA−EE−A180 TCGA−EE−A2A2 TCGA−EE−A182 SKCM−JWCI−14−Tumor TCGA−IH−A3EA SKCM−Ma−Mel−35−Tumor SKCM−Ma−Mel−119−Tumor TCGA−FS−A1Z3 TCGA−EE−A3AH TCGA−EE−A2MU TCGA−BF−A3DM SKCM−JWCI−WGS−43−Tumor SKCM−JWCI−WGS−34−Tumor SKCM−JWCI−WGS−26−Tumor ME010−Tumor TCGA−FS−A1ZE SKCM−JWCI−WGS−39−Tumor TCGA−EE−A3J7 TCGA−EE−A2GI TCGA−EE−A29A TCGA−DA−A1I8 TCGA−D3−A2JK SKCM−JWCI−WGS−15−Tumor SKCM−13456−Tumor TCGA−EE−A20C TCGA−EE−A181 TCGA−FS−A1ZZ TCGA−EE−A29M TCGA−GN−A268 TCGA−ER−A19F TCGA−EE−A3AG TCGA−EE−A17X ME009−Tumor TCGA−EE−A20F TCGA−D3−A2J7 SKCM−Ma−Mel−48−Tumor ME035−Tumor SKCM−JWCI−WGS−12−Tumor SKCM−JWCI−WGS−1−Tumor TCGA−ER−A198 SKCM−Ma−Mel−67−Tumor TCGA−GN−A26C TCGA−FS−A1ZP TCGA−EE−A2GO TCGA−EE−A20H TCGA−D3−A2JF TCGA−FS−A1ZQ TCGA−ER−A19G TCGA−EE−A3AB TCGA−EE−A2MG TCGA−EE−A29L TCGA−EE−A29C TCGA−D3−A3CB SKCM−Ma−Mel−85−Tumor SKCM−13473−Tumor ME017−Tumor ME001−Tumor TCGA−ER−A193 SKCM−Ma−Mel−65−Tumor TCGA−FS−A1ZA TCGA−EE−A3JI TCGA−EE−A3JD TCGA−EE−A2MJ TCGA−EE−A2GM TCGA−D3−A2J8 SKCM−Ma−Mel−103b−Tumor SKCM−Ma−Mel−102−Tumor SKCM−JWCI−WGS−25−Tumor TCGA−ER−A19A TCGA−EE−A3JA TCGA−EE−A3AE TCGA−EE−A3AA TCGA−EE−A2MI TCGA−EE−A2M5 TCGA−EE−A2GJ TCGA−EE−A2GD TCGA−EE−A183 TCGA−D3−A3C7 TCGA−BF−A1PX SKCM−JWCI−WGS−7−Tumor SKCM−JWCI−WGS−21−Tumor TCGA−HR−A2OG TCGA−EE−A2A5 TCGA−D3−A1QB TCGA−BF−A1PZ SKCM−Ma−Mel−105−Tumor ME048−Tumor ME044−Tumor ME021−Tumor

TP53 Network FDR = 4.2e−12%, FDR nod = 2.1e−05% Mitochondrial Beta Oxidation Of Medium Chain Saturated Fatty Acids FDR = 0.42%, FDR nod = 1.5%

unknown CG mut ACSM1

unknown CG mut

known HCG mut ACADM

TP53 known HCG mut

wt

TP63 HADHA

wt

HADHB

TNFSF10

ACAA2

ECHS1

MYC

SLC25A20

TP73

SKCM−Ma−Mel−36−Tumor TCGA−FS−A1ZF TCGA−ER−A194 TCGA−EE−A2A2 TCGA−EE−A29V TCGA−EE−A29G TCGA−ER−A19G TCGA−EE−A2ML TCGA−EE−A2M7 TCGA−EE−A2GT TCGA−EE−A2GI TCGA−ER−A19K TCGA−ER−A19D TCGA−EE−A3AA TCGA−EE−A2GD TCGA−EE−A183 TCGA−ER−A19F TCGA−FS−A1ZC SKCM−Ma−Mel−67−Tumor SKCM−JWCI−WGS−1−Tumor TCGA−HR−A2OH TCGA−FS−A1ZK TCGA−FS−A1ZA TCGA−EE−A3JI TCGA−EE−A3JE TCGA−EE−A3JA TCGA−EE−A3J7 TCGA−EE−A3AF TCGA−EE−A3AD TCGA−EE−A2MF TCGA−EE−A2MD TCGA−EE−A2M5 TCGA−EE−A2GO TCGA−EE−A29P TCGA−EE−A29M TCGA−EE−A182 TCGA−EE−A180 TCGA−DA−A3F5 TCGA−DA−A1IC TCGA−D3−A2J7 TCGA−D3−A1Q1 TCGA−BF−A3DL SKCM−Ma−Mel−85−Tumor SKCM−Ma−Mel−62−Tumor SKCM−Ma−Mel−119−Tumor SKCM−Ma−Mel−103b−Tumor SKCM−JWCI−WGS−35−Tumor SKCM−JWCI−WGS−33−Tumor SKCM−JWCI−27−Tumor ME029−Tumor ME017−Tumor ME009−Tumor

SUMO1

TP53 Regulates Transcription Of Death Receptors And Ligands FDR = 1.6e−11%, FDR nod = 0.43%

[CGB Protein Results In Increased Activity Of LHCGR Protein] [N (2 Cyclohexyloxy 4 Nitrophenyl)methanesulfonamide Results In Decreased Activity Of PTGS2 Protein] Inhibits The Reaction [CGB Protein Results In Increased Chemical Synthesis Of Dinoprost] [N3 Cyclopropyl 7 ((4 (1 Methylethyl)phenyl)methyl) 7H Pyrrolo(3, 2 F)quinazoline 1,3 Diamine Binds To F2R Protein] Promotes The Reaction [CGB Protein Results In Increased Chemical Synthesis Of Progest known HCG mut Atrazine Inhibits The Reaction [CGB Protein Results In Increased Chemical Synthesis Of Androgens] Atrazine Inhibits The Reaction [CGB Protein Results In Increased Secretion Of Cyclic AMP] TP53BP2 Colforsin Promotes The Reaction [CGB Protein Results In Increased Abundance Of Cyclic AMP] Finasteride Promotes The Reaction [[Gonadotropins, Equine Co Treated With CGB Protein] Results In Increased Abundance Of Progesterone] PPP1R13B wt Flame Retardants Inhibits The Reaction [[CGB Protein Co Treated With Colforsin] Results In Increased Abundance Of Cyclic AMP] KISS1 Protein Promotes The Reaction [CGB Protein Results In Increased Abundance Of Progesterone] FAS Lansoprazole Metabolite Inhibits The Reaction [CGB Protein Results In Increased Abundance Of Testosterone] Manganese Chloride Inhibits The Reaction [CGB Protein Results In Increased Expression Of STAR Protein] Progesterone Promotes The Reaction [CGB Protein Results In Increased Expression Of VEGFA MRNA] TNFRSF10D Testosterone Enanthate Inhibits The Reaction [CGB Protein Results In Increased Abundance Of Androgens] FDR = 0.19%, FDR nod = 0.72% TNFRSF10A TP53

unknown CG mut

TP63

TMEM219

known HCG mut

LHCGR

IGFBP3

STAR

TNFRSF10C

CGB3

TP73

CGB7

wt

TNFRSF10B

unknown CG mut

TCGA−FR−A2OS

TCGA−ER−A19P

TCGA−EE−A181

ME011−Tumor

TCGA−EE−A29L

TCGA−FS−A1ZK

TCGA−FS−A1ZB

TCGA−FS−A1Z3

TCGA−ER−A19K

TCGA−ER−A193

TCGA−EE−A3JI

TCGA−EE−A3JD

TCGA−EE−A3AF

TCGA−EE−A3AB

TCGA−EE−A2MU

TCGA−EE−A2ME

TCGA−EE−A2GI

TCGA−EE−A2GC

TCGA−EE−A29S

TCGA−EE−A29M

TCGA−EE−A20C

TCGA−EE−A183

TCGA−DA−A1I0

TCGA−BF−A3DJ

SKCM−Ma−Mel−67−Tumor




SKCM−JWCI−WGS−43−Tumor





TCGA−EE−A2GL TCGA−FS−A1Z3 TCGA−EE−A29B TCGA−BF−A1PU ME043−Tumor TCGA−EE−A29G SKCM−Ma−Mel−107−Tumor SKCM−JWCI−WGS−39−Tumor TCGA−EE−A3AB TCGA−EE−A29A ME024−Tumor ME020−Tumor SKCM−JWCI−WGS−12−Tumor TCGA−HR−A2OG TCGA−FS−A1ZQ TCGA−EE−A29L TCGA−D3−A3MV TCGA−EE−A3JB TCGA−EE−A2GI TCGA−EE−A29S TCGA−D3−A1QB SKCM−JWCI−WGS−13−Tumor TCGA−HR−A2OH TCGA−EE−A2GO TCGA−EE−A20H TCGA−D3−A1Q6 TCGA−BF−A3DM Mel−BRAFi−03−Tumor TCGA−FS−A1ZD TCGA−EE−A3J3 TCGA−EE−A2MT TCGA−EE−A2A6 TCGA−EE−A20B SKCM−UKRV−Mel−6−Tumor SKCM−13473−Tumor ME048−Tumor ME009−Tumor TCGA−EE−A2GR TCGA−ER−A19F TCGA−EE−A3AF TCGA−EE−A2MJ TCGA−EE−A2MD TCGA−EE−A2M5 TCGA−EE−A29R TCGA−EE−A29N SKCM−Ma−Mel−67−Tumor TCGA−IH−A3EA TCGA−GN−A267 TCGA−FS−A1ZZ TCGA−FS−A1ZE TCGA−FS−A1ZA TCGA−FS−A1Z7 TCGA−ER−A194 TCGA−ER−A193 TCGA−EE−A2ML TCGA−EE−A2MK TCGA−EE−A2MC TCGA−EE−A2GB TCGA−EE−A29H TCGA−EE−A29C TCGA−D3−A3MU TCGA−D3−A3ML TCGA−D3−A3C7 TCGA−D3−A2JK SKCM−Ma−Mel−79−Tumor SKCM−Ma−Mel−114−Tumor SKCM−Ma−Mel−103b−Tumor SKCM−JWCI−WGS−7−Tumor SKCM−JWCI−WGS−43−Tumor SKCM−JWCI−WGS−36−Tumor SKCM−JWCI−WGS−35−Tumor SKCM−JWCI−WGS−33−Tumor SKCM−JWCI−WGS−24−Tumor SKCM−JWCI−WGS−22−Tumor SKCM−JWCI−WGS−1−Tumor SKCM−13575−Tumor SKCM−13567−Tumor SKCM−13463−Tumor ME041−Tumor TCGA−EE−A181 TCGA−EE−A2GC TCGA−DA−A1HV SKCM−JWCI−27−Tumor TCGA−EE−A3JI TCGA−EE−A3JD TCGA−EE−A3J8 TCGA−EE−A3J7 TCGA−EE−A3AG TCGA−EE−A2MQ TCGA−EE−A2MM TCGA−EE−A2GP TCGA−EE−A2A2 TCGA−EE−A29M TCGA−D3−A2JA TCGA−GN−A26C TCGA−FS−A1ZW TCGA−FS−A1Z4 TCGA−ER−A3ET TCGA−ER−A19E TCGA−ER−A199 TCGA−EE−A3J5 TCGA−EE−A3AE TCGA−EE−A3AD TCGA−EE−A3AA TCGA−EE−A2MU TCGA−EE−A2GT TCGA−EE−A2GJ TCGA−EE−A29X TCGA−EE−A29V TCGA−EB−A299 TCGA−DA−A1I5 TCGA−DA−A1HW TCGA−D3−A1QA TCGA−BF−A3DL SKCM−Ma−Mel−86−Tumor SKCM−Ma−Mel−85−Tumor SKCM−Ma−Mel−119−Tumor SKCM−Ma−Mel−102−Tumor SKCM−Ma−Mel−08a−Tumor SKCM−JWCI−WGS−8−Tumor SKCM−JWCI−WGS−32−Tumor SKCM−JWCI−WGS−25−Tumor SKCM−JWCI−WGS−21−Tumor SKCM−JWCI−WGS−19−Tumor SKCM−JWCI−WGS−11−Tumor SKCM−JWCI−14−Tumor ME029−Tumor ME021−Tumor ME017−Tumor ME016−Tumor

PDGF Receptor Signaling Network FDR = 0.82%, FDR nod = 2.7% Neurophilin Interactions With VEGF And VEGFR FDR = 0.05%, FDR nod = 0.21%

unknown CG mut

TCGA−GN−A263 TCGA−D3−A1Q6 SKCM−UKRV−Mel−24−Tumor TCGA−EE−A3AF TCGA−EE−A29H ME009−Tumor TCGA−ER−A19P TCGA−ER−A195 TCGA−EE−A2MN TCGA−EE−A2A1 TCGA−BF−A3DN TCGA−BF−A1PZ TCGA−FS−A1ZZ TCGA−EE−A3J4 TCGA−EE−A3AA TCGA−EE−A2MJ TCGA−EE−A2GC TCGA−EE−A2A6 TCGA−D3−A2JK TCGA−D3−A1Q7 SKCM−Ma−Mel−114−Tumor TCGA−GN−A26C TCGA−EE−A2A2 TCGA−EE−A29S TCGA−EE−A183 TCGA−BF−A1Q0 SKCM−JWCI−WGS−12−Tumor TCGA−IH−A3EA TCGA−EE−A3AH TCGA−EE−A2MS TCGA−EE−A2GR TCGA−DA−A1IA TCGA−D3−A2JO TCGA−BF−A3DM SKCM−Ma−Mel−65−Tumor SKCM−JWCI−27−Tumor ME018−Tumor ME017−Tumor ME012−Tumor TCGA−EE−A2GJ TCGA−EE−A181 TCGA−ER−A2NH TCGA−ER−A193 TCGA−EE−A2MU TCGA−EE−A2GO TCGA−DA−A1HV Mel−BRAFi−03−Tumor TCGA−FS−A1ZQ TCGA−FS−A1ZB TCGA−EE−A3JB TCGA−EE−A3JA TCGA−EE−A3AG TCGA−EE−A2MP TCGA−EE−A2MC TCGA−EE−A2M5 TCGA−EE−A2GH TCGA−EE−A29Q TCGA−EE−A182 TCGA−D3−A3C1 TCGA−D3−A1Q3 SKCM−Ma−Mel−94−Tumor SKCM−Ma−Mel−92−Tumor SKCM−Ma−Mel−119−Tumor SKCM−JWCI−WGS−43−Tumor SKCM−JWCI−WGS−33−Tumor SKCM−JWCI−WGS−22−Tumor SKCM−JWCI−WGS−11−Tumor Mel_BRAFi_02_PRE−Tumor ME024−Tumor ME016−Tumor TCGA−FS−A1ZA TCGA−EE−A3AE SKCM−Ma−Mel−48−Tumor SKCM−Ma−Mel−103b−Tumor TCGA−D9−A1JW TCGA−FS−A1ZC TCGA−FS−A1Z3 TCGA−ER−A1A1 TCGA−EE−A3JD TCGA−EE−A3AC TCGA−EE−A2MD TCGA−EE−A20F TCGA−EE−A20C TCGA−EB−A24D TCGA−DA−A1HW TCGA−D3−A3MV TCGA−D3−A2JL TCGA−D3−A2JF TCGA−BF−A3DJ SKCM−Ma−Mel−67−Tumor SKCM−JWCI−WGS−1−Tumor SKCM−JWCI−14−Tumor TCGA−FS−A1ZK TCGA−ER−A19S TCGA−ER−A19G TCGA−EE−A2GS TCGA−EE−A2GI TCGA−EE−A29X TCGA−EE−A29B TCGA−EE−A29A TCGA−DA−A1IC TCGA−DA−A1HY TCGA−D3−A3ML TCGA−BF−A3DL SKCM−JWCI−WGS−7−Tumor SKCM−JWCI−WGS−6−Tumor SKCM−JWCI−WGS−39−Tumor SKCM−JWCI−WGS−25−Tumor ME020−Tumor

TCGA−EE−A3AD SKCM−Ma−Mel−86−Tumor TCGA−EE−A180 TCGA−D3−A3C8 TCGA−FS−A1ZK TCGA−EE−A29B TCGA−ER−A194 SKCM−Ma−Mel−48−Tumor TCGA−ER−A19S TCGA−ER−A193 SKCM−13591−Tumor TCGA−EE−A20H TCGA−EB−A3HV SKCM−JWCI−WGS−2−Tumor TCGA−EE−A2MJ TCGA−EE−A2MP TCGA−D9−A1JW TCGA−EE−A29N TCGA−D3−A1QA TCGA−D3−A1Q6 TCGA−GN−A269 TCGA−ER−A2NF TCGA−EE−A3AH ME015−Tumor TCGA−FS−A1ZF TCGA−ER−A19E TCGA−EE−A3JE SKCM−Ma−Mel−76−Tumor SKCM−JWCI−WGS−15−Tumor ME041−Tumor TCGA−EE−A2M5 SKCM−JWCI−WGS−32−Tumor TCGA−ER−A19G TCGA−EE−A2GI SKCM−JWCI−WGS−20−Tumor SKCM−JWCI−WGS−18−Tumor ME045−Tumor TCGA−EE−A181 TCGA−DA−A1IC TCGA−EE−A3JD TCGA−DA−A3F5 SKCM−JWCI−WGS−6−Tumor SKCM−JWCI−WGS−25−Tumor ME033−Tumor TCGA−FS−A1ZC TCGA−EE−A2GS TCGA−DA−A1I0 TCGA−D3−A3MR SKCM−JWCI−WGS−8−Tumor TCGA−ER−A19P TCGA−EE−A29M TCGA−BF−A1Q0 TCGA−FS−A1ZN TCGA−EE−A20F TCGA−FS−A1YY TCGA−ER−A19K TCGA−EE−A3AA TCGA−EE−A29C TCGA−DA−A1IB TCGA−D3−A3CE TCGA−D3−A2J6 SKCM−Ma−Mel−85−Tumor ME043−Tumor TCGA−D3−A2JF SKCM−JWCI−WGS−1−Tumor TCGA−GN−A26C TCGA−EE−A3J5 TCGA−EE−A2GO SKCM−JWCI−WGS−7−Tumor SKCM−JWCI−WGS−22−Tumor TCGA−EE−A2MI TCGA−EE−A2MG TCGA−EE−A2GR TCGA−EE−A182 TCGA−D3−A3C1 SKCM−13537−Tumor TCGA−EE−A2GC TCGA−D3−A3MU SKCM−Ma−Mel−63−Tumor SKCM−Ma−Mel−123−Tumor SKCM−Ma−Mel−120−Tumor SKCM−Ma−Mel−114−Tumor SKCM−Ma−Mel−04−Tumor SKCM−JWCI−WGS−34−Tumor SKCM−JWCI−WGS−23−Tumor ME024−Tumor TCGA−EE−A2MD TCGA−EE−A29S TCGA−EE−A29L SKCM−JWCI−27−Tumor TCGA−EE−A3JA TCGA−EE−A2A5 SKCM−Ma−Mel−65−Tumor SKCM−Ma−Mel−105−Tumor SKCM−13575−Tumor ME009−Tumor TCGA−HR−A2OG TCGA−FS−A1ZT TCGA−FS−A1ZB TCGA−FS−A1ZA TCGA−FS−A1Z3 TCGA−FS−A1Z0 TCGA−ER−A2NH TCGA−EE−A3JI TCGA−EE−A3J7 TCGA−EE−A2MU TCGA−EE−A2MF TCGA−EE−A2GN TCGA−EE−A2GJ TCGA−EE−A2A2 TCGA−EE−A2A1 TCGA−EE−A17X TCGA−DA−A3F3 TCGA−D3−A2JO SKCM−Ma−Mel−37−Tumor SKCM−Ma−Mel−35−Tumor SKCM−Ma−Mel−119−Tumor SKCM−Ma−Mel−103b−Tumor SKCM−Ma−Mel−102−Tumor TCGA−GN−A268 TCGA−GN−A267 TCGA−FS−A1ZZ TCGA−FS−A1ZY TCGA−FS−A1ZW TCGA−FS−A1ZQ TCGA−FS−A1ZP TCGA−FS−A1ZE TCGA−FS−A1YW TCGA−ER−A2NE TCGA−ER−A2NC TCGA−ER−A2NB TCGA−ER−A19N TCGA−ER−A19D TCGA−ER−A199 TCGA−ER−A195 TCGA−EE−A3J8 TCGA−EE−A3AC TCGA−EE−A2MN TCGA−EE−A2MM TCGA−EE−A2ML TCGA−EE−A2MC TCGA−EE−A2GU TCGA−EE−A2GP TCGA−EE−A2GM TCGA−EE−A2GL TCGA−EE−A2GD TCGA−EE−A29X TCGA−EE−A29V TCGA−EE−A29R TCGA−EE−A29Q TCGA−EE−A29G TCGA−EE−A20C TCGA−EE−A185 TCGA−EE−A184 TCGA−EB−A1NK TCGA−DA−A1I1 TCGA−DA−A1HV TCGA−D3−A3MV TCGA−D3−A3ML TCGA−D3−A2JL TCGA−D3−A2J8 TCGA−D3−A1QB TCGA−D3−A1Q8 TCGA−D3−A1Q1 TCGA−BF−A1PZ TCGA−BF−A1PV SKCM−Ma−Mel−94−Tumor SKCM−Ma−Mel−91−Tumor SKCM−Ma−Mel−79−Tumor SKCM−Ma−Mel−53−Tumor SKCM−Ma−Mel−28−Tumor SKCM−Ma−Mel−05−Tumor SKCM−JWCI−WGS−43−Tumor SKCM−JWCI−WGS−29−Tumor SKCM−JWCI−WGS−26−Tumor SKCM−13463−Tumor ME049−Tumor ME044−Tumor ME035−Tumor ME030−Tumor ME018−Tumor ME014−Tumor ME011−Tumor ME010−Tumor ME002−Tumor ME001−Tumor

TP53 Regulates Transcription Of Death Receptors And Ligands FDR = 1.6e−11%, FDR nod = 0.43% Apoptotic Cleavage Of Cell Adhesion Proteins FDR = 4.6e−12%, FDR nod = 9.4e−11%


wt wt

FLT1

wt

GRB14

VEGFC

DOK2

NRP1

PIK3R1

FIGF

HRAS

NRP2

PTPN11

VEGFA

ANGPT2


TP53 DSP

TP53BP2 DSG3

FAS

DSG2

TJP1

TNFRSF10D

OCLN

TNFRSF10A

TJP2

TMEM219

IGFBP3

CDH1

TNFRSF10B

TNFRSF10C

CASP3

TP73

PKP1

known HCG mut

TEK

wt PPP1R13B wt CTNNB1


TP63 DSG1

wt

FLT4

PIK3CA

known HCG mut PIK3CB

ME050−Tumor TCGA−EE−A3JA TCGA−EE−A2GP SKCM−JWCI−WGS−1−Tumor TCGA−EE−A2GN TCGA−EE−A2A0 TCGA−DA−A1HY SKCM−Ma−Mel−114−Tumor SKCM−JWCI−WGS−35−Tumor TCGA−FS−A1ZZ TCGA−EE−A3AF TCGA−EE−A3AD TCGA−EE−A3AA TCGA−EE−A2MJ TCGA−EE−A2GR TCGA−EE−A2GD TCGA−EE−A29L TCGA−EE−A20I TCGA−EE−A181 SKCM−JWCI−WGS−6−Tumor ME001−Tumor TCGA−GN−A26C TCGA−EE−A2MT TCGA−DA−A1IC TCGA−FS−A1ZC TCGA−ER−A19P TCGA−EE−A3AC TCGA−EE−A2GO TCGA−EE−A182 TCGA−D3−A3ML TCGA−D3−A2JN TCGA−BF−A1Q0 SKCM−UKRV−Mel−20−Tumor SKCM−JWCI−WGS−29−Tumor SKCM−JWCI−WGS−25−Tumor SKCM−13473−Tumor ME030−Tumor TCGA−ER−A199 TCGA−EE−A3AE TCGA−D3−A3C8 TCGA−FS−A1ZK TCGA−FS−A1ZF TCGA−FS−A1ZB TCGA−FS−A1ZA TCGA−FS−A1Z3 TCGA−ER−A19K TCGA−EE−A3JD TCGA−EE−A3J3 TCGA−EE−A2MS TCGA−EE−A2MD TCGA−EE−A2GL TCGA−EE−A2GC TCGA−EE−A29V TCGA−EE−A29Q TCGA−D3−A3CB TCGA−D3−A2JF TCGA−BF−A3DL TCGA−BF−A1PZ SKCM−Ma−Mel−59−Tumor SKCM−Ma−Mel−37−Tumor SKCM−Ma−Mel−103b−Tumor SKCM−Ma−Mel−04−Tumor SKCM−JWCI−WGS−7−Tumor SKCM−JWCI−WGS−22−Tumor Mel−BRAFi−03−Tumor

TCGA−EE−A29S TCGA−D3−A1Q6 SKCM−UKRV−Mel−24−Tumor TCGA−ER−A19P TCGA−GN−A26C TCGA−FS−A1ZZ TCGA−ER−A195 TCGA−EE−A2MN TCGA−EE−A2A1 TCGA−EE−A183 TCGA−BF−A3DN TCGA−BF−A1Q0 TCGA−BF−A1PZ TCGA−ER−A193 TCGA−EE−A2MU TCGA−EE−A2GJ TCGA−EE−A181 TCGA−DA−A1HV Mel−BRAFi−03−Tumor TCGA−FS−A1ZQ TCGA−FS−A1ZB TCGA−ER−A2NH TCGA−EE−A3JB TCGA−EE−A3JA TCGA−EE−A3AG TCGA−EE−A2MP TCGA−EE−A2MC TCGA−EE−A2M5 TCGA−EE−A2GO TCGA−EE−A2GH TCGA−EE−A29Q TCGA−EE−A182 TCGA−D3−A3C1 TCGA−D3−A1Q3 SKCM−Ma−Mel−94−Tumor SKCM−Ma−Mel−92−Tumor SKCM−Ma−Mel−119−Tumor SKCM−JWCI−WGS−43−Tumor SKCM−JWCI−WGS−33−Tumor SKCM−JWCI−WGS−22−Tumor SKCM−JWCI−WGS−11−Tumor Mel_BRAFi_02_PRE−Tumor ME024−Tumor ME016−Tumor TCGA−FS−A1ZA TCGA−EE−A3AE SKCM−Ma−Mel−103b−Tumor TCGA−ER−A1A1 TCGA−EE−A3JD TCGA−EB−A24D TCGA−D9−A1JW TCGA−D3−A2JL TCGA−BF−A3DJ SKCM−Ma−Mel−48−Tumor TCGA−FS−A1ZK TCGA−FS−A1ZC TCGA−FS−A1Z3 TCGA−ER−A19S TCGA−ER−A19G TCGA−EE−A3AC TCGA−EE−A2MD TCGA−EE−A2GS TCGA−EE−A2GI TCGA−EE−A29X TCGA−EE−A29B TCGA−EE−A29A TCGA−EE−A20F TCGA−EE−A20C TCGA−DA−A1IC TCGA−DA−A1HY TCGA−DA−A1HW TCGA−D3−A3MV TCGA−D3−A3ML TCGA−D3−A2JF TCGA−BF−A3DL SKCM−Ma−Mel−67−Tumor SKCM−JWCI−WGS−7−Tumor SKCM−JWCI−WGS−6−Tumor SKCM−JWCI−WGS−39−Tumor SKCM−JWCI−WGS−25−Tumor SKCM−JWCI−WGS−1−Tumor SKCM−JWCI−14−Tumor ME020−Tumor

NRAS

VEGF And VEGFR Signaling Network VEGF Binds To VEGFR Leading To Receptor Dimerization FDR = 0.71%, FDR nod = 2.3%

Tie2 Signaling FDR = 5.6e−12%, FDR nod = 3.7%


PDGFRA KDR

PDGFRB

FLT1

PDGFC

NRP1

PDGFD

PDGFB

NRP2

PDGFA

ANGPT1

KDR

unknown CG mut

SOS1

GRB7

PIK3R2

KRAS

ANGPT4

GRB2

SHC1

VEGFB

TCGA−EE−A2GL TCGA−FS−A1Z3 TCGA−EE−A29B TCGA−BF−A1PU ME043−Tumor TCGA−EE−A29G SKCM−Ma−Mel−107−Tumor SKCM−JWCI−WGS−39−Tumor TCGA−EE−A3AB TCGA−EE−A29A ME024−Tumor ME020−Tumor SKCM−JWCI−WGS−12−Tumor TCGA−HR−A2OG TCGA−FS−A1ZQ TCGA−EE−A29L TCGA−D3−A3MV TCGA−EE−A3JB TCGA−EE−A2GI TCGA−EE−A29S TCGA−D3−A1QB SKCM−JWCI−WGS−13−Tumor TCGA−HR−A2OH TCGA−EE−A2GO TCGA−EE−A20H TCGA−D3−A1Q6 TCGA−BF−A3DM Mel−BRAFi−03−Tumor TCGA−FS−A1ZD TCGA−EE−A3J3 TCGA−EE−A2MT TCGA−EE−A2A6 TCGA−EE−A20B SKCM−UKRV−Mel−6−Tumor SKCM−13473−Tumor ME048−Tumor ME009−Tumor TCGA−EE−A2GR TCGA−ER−A19F TCGA−EE−A3AF TCGA−EE−A2MJ TCGA−EE−A2MD TCGA−EE−A2M5 TCGA−EE−A29R TCGA−EE−A29N SKCM−Ma−Mel−67−Tumor TCGA−IH−A3EA TCGA−GN−A267 TCGA−FS−A1ZZ TCGA−FS−A1ZE TCGA−FS−A1ZA TCGA−FS−A1Z7 TCGA−ER−A194 TCGA−ER−A193 TCGA−EE−A2ML TCGA−EE−A2MK TCGA−EE−A2MC TCGA−EE−A2GB TCGA−EE−A29H TCGA−EE−A29C TCGA−D3−A3MU TCGA−D3−A3ML TCGA−D3−A3C7 TCGA−D3−A2JK SKCM−Ma−Mel−79−Tumor SKCM−Ma−Mel−114−Tumor SKCM−Ma−Mel−103b−Tumor SKCM−JWCI−WGS−7−Tumor SKCM−JWCI−WGS−43−Tumor SKCM−JWCI−WGS−36−Tumor SKCM−JWCI−WGS−35−Tumor SKCM−JWCI−WGS−33−Tumor SKCM−JWCI−WGS−24−Tumor SKCM−JWCI−WGS−22−Tumor SKCM−JWCI−WGS−1−Tumor SKCM−13575−Tumor SKCM−13567−Tumor SKCM−13463−Tumor ME041−Tumor TCGA−EE−A181 TCGA−EE−A2GC TCGA−DA−A1HV SKCM−JWCI−27−Tumor TCGA−EE−A3JI TCGA−EE−A3JD TCGA−EE−A3J8 TCGA−EE−A3J7 TCGA−EE−A3AG TCGA−EE−A2MQ TCGA−EE−A2MM TCGA−EE−A2GP TCGA−EE−A2A2 TCGA−EE−A29M TCGA−D3−A2JA TCGA−GN−A26C TCGA−FS−A1ZW TCGA−FS−A1Z4 TCGA−ER−A3ET TCGA−ER−A19E TCGA−ER−A199 TCGA−EE−A3J5 TCGA−EE−A3AE TCGA−EE−A3AD TCGA−EE−A3AA TCGA−EE−A2MU TCGA−EE−A2GT TCGA−EE−A2GJ TCGA−EE−A29X TCGA−EE−A29V TCGA−EB−A299 TCGA−DA−A1I5 TCGA−DA−A1HW TCGA−D3−A1QA TCGA−BF−A3DL SKCM−Ma−Mel−86−Tumor SKCM−Ma−Mel−85−Tumor SKCM−Ma−Mel−119−Tumor SKCM−Ma−Mel−102−Tumor SKCM−Ma−Mel−08a−Tumor SKCM−JWCI−WGS−8−Tumor SKCM−JWCI−WGS−32−Tumor SKCM−JWCI−WGS−25−Tumor SKCM−JWCI−WGS−21−Tumor SKCM−JWCI−WGS−19−Tumor SKCM−JWCI−WGS−11−Tumor SKCM−JWCI−14−Tumor ME029−Tumor ME021−Tumor ME017−Tumor ME016−Tumor

SKCM−Ma−Mel−79−Tumor TCGA−EE−A2A6 SKCM−JWCI−WGS−36−Tumor ME018−Tumor SKCM−Ma−Mel−55−Tumor SKCM−Ma−Mel−35−Tumor TCGA−ER−A195 SKCM−Ma−Mel−37−Tumor SKCM−JWCI−WGS−8−Tumor TCGA−EE−A3J3 TCGA−EE−A2GM SKCM−Ma−Mel−63−Tumor SKCM−13561−Tumor TCGA−EE−A29V SKCM−UKRV−Mel−20−Tumor TCGA−GN−A265 TCGA−ER−A19T TCGA−EE−A29P TCGA−EE−A20F SKCM−JWCI−WGS−32−Tumor ME017−Tumor TCGA−FS−A1YY TCGA−EE−A180 SKCM−JWCI−WGS−4−Tumor ME050−Tumor TCGA−GN−A269 TCGA−ER−A19O TCGA−EE−A29A TCGA−D9−A149 TCGA−D3−A2JN TCGA−D3−A1Q5 ME045−Tumor ME020−Tumor ME014−Tumor TCGA−ER−A19P SKCM−Ma−Mel−85−Tumor TCGA−EE−A2GR SKCM−Ma−Mel−114−Tumor SKCM−JWCI−WGS−23−Tumor TCGA−ER−A19S TCGA−ER−A19N TCGA−ER−A19G TCGA−ER−A196 TCGA−EE−A3J5 TCGA−EE−A2MI TCGA−EE−A2MC TCGA−EE−A2M6 TCGA−EE−A2GN TCGA−EE−A2GJ TCGA−EE−A29R TCGA−DA−A1IC TCGA−DA−A1I7 TCGA−DA−A1I2 TCGA−DA−A1I0 TCGA−DA−A1HW TCGA−D3−A3C7 TCGA−D3−A2JA SKCM−JWCI−WGS−3−Tumor SKCM−JWCI−14−Tumor TCGA−EE−A3JD SKCM−JWCI−27−Tumor TCGA−ER−A194 TCGA−EE−A2GO TCGA−EE−A2A5 TCGA−D3−A3MV SKCM−JWCI−WGS−7−Tumor ME011−Tumor TCGA−GN−A26A TCGA−GN−A263 TCGA−FS−A1ZW TCGA−FS−A1ZP TCGA−ER−A2NH TCGA−ER−A19E TCGA−EE−A3JI TCGA−EE−A3AA TCGA−EE−A29G TCGA−EE−A184 TCGA−D3−A3C8 TCGA−D3−A2JK TCGA−D3−A1QB TCGA−D3−A1Q6 TCGA−D3−A1Q4 SKCM−UKRV−Mel−6−Tumor SKCM−JWCI−WGS−42−Tumor SKCM−JWCI−WGS−34−Tumor SKCM−JWCI−WGS−20−Tumor SKCM−13473−Tumor SKCM−13463−Tumor ME024−Tumor ME021−Tumor TCGA−EE−A181 TCGA−DA−A1HV TCGA−EE−A3AC TCGA−EE−A2M5 TCGA−EE−A2GC TCGA−EE−A182 SKCM−Ma−Mel−67−Tumor SKCM−Ma−Mel−102−Tumor ME009−Tumor TCGA−IH−A3EA TCGA−FS−A1ZZ TCGA−FS−A1ZK TCGA−FS−A1Z3 TCGA−ER−A193 TCGA−EE−A3AF TCGA−EE−A2MS TCGA−EE−A2MJ TCGA−EE−A29L TCGA−DA−A3F8 TCGA−DA−A1I5 TCGA−DA−A1HY TCGA−BF−A3DL SKCM−Ma−Mel−36−Tumor SKCM−JWCI−WGS−1−Tumor TCGA−GN−A26C TCGA−GN−A267 TCGA−FS−A1ZQ TCGA−FS−A1ZA TCGA−EE−A3JA TCGA−EE−A3J8 TCGA−EE−A3AE TCGA−EE−A2MF TCGA−EE−A2MD TCGA−EE−A2GI TCGA−EE−A29C TCGA−EE−A20H TCGA−EE−A20C TCGA−EE−A183 TCGA−EB−A24D TCGA−DA−A1I1 SKCM−UKRV−Mel−24−Tumor SKCM−Ma−Mel−65−Tumor SKCM−Ma−Mel−48−Tumor SKCM−Ma−Mel−103b−Tumor SKCM−JWCI−WGS−43−Tumor SKCM−JWCI−WGS−35−Tumor SKCM−JWCI−WGS−25−Tumor SKCM−JWCI−WGS−12−Tumor SKCM−13447−Tumor ME044−Tumor TCGA−FS−A1ZR TCGA−FS−A1Z0 TCGA−ER−A2NB TCGA−EE−A3AG TCGA−EE−A2MQ TCGA−EE−A2MP TCGA−EE−A2GP TCGA−EE−A2GL TCGA−EE−A2GD TCGA−EE−A2A2 TCGA−EE−A29N TCGA−EE−A29M TCGA−EE−A17X TCGA−D3−A3ML TCGA−D3−A2JH TCGA−D3−A2JF TCGA−D3−A2JD TCGA−D3−A2J8 TCGA−BF−A1PV SKCM−Ma−Mel−94−Tumor SKCM−Ma−Mel−119−Tumor SKCM−Ma−Mel−105−Tumor SKCM−JWCI−WGS−22−Tumor SKCM−JWCI−WGS−13−Tumor ME002−Tumor

ErbB Receptor Signaling Network FDR = 1.1%, FDR nod = 1.5% TRIF Mediated Programmed Cell Death FDR = 0.007%, FDR nod = 0.001%

TCGA−EE−A2GH TCGA−EB−A24D TCGA−EE−A29B TCGA−BF−A3DM SKCM−UKRV−Mel−6−Tumor TCGA−GN−A263 SKCM−Ma−Mel−65−Tumor TCGA−EE−A3AE TCGA−ER−A19D TCGA−EE−A2GS TCGA−ER−A194 TCGA−EE−A181 TCGA−DA−A3F8 TCGA−DA−A1I5 SKCM−Ma−Mel−120−Tumor TCGA−GN−A267 TCGA−FS−A1ZZ TCGA−ER−A193 TCGA−EE−A29N TCGA−D3−A3MV SKCM−JWCI−WGS−43−Tumor TCGA−EE−A3AB TCGA−GN−A269 TCGA−ER−A19E TCGA−EE−A2MI TCGA−EE−A2M7 TCGA−EE−A29S TCGA−EE−A17X SKCM−UKRV−Mel−20−Tumor SKCM−Ma−Mel−102−Tumor SKCM−13473−Tumor TCGA−GN−A26C TCGA−EE−A2A5 TCGA−EE−A29T TCGA−EB−A1NK TCGA−DA−A1I7 TCGA−DA−A1HV TCGA−D3−A3C8 SKCM−Ma−Mel−54a−Tumor SKCM−Ma−Mel−27−Tumor SKCM−JWCI−WGS−35−Tumor SKCM−JWCI−WGS−23−Tumor SKCM−JWCI−27−Tumor TCGA−EE−A3AD TCGA−EE−A2MF TCGA−DA−A3F3 TCGA−BF−A1Q0 SKCM−Ma−Mel−48−Tumor SKCM−JWCI−WGS−12−Tumor SKCM−13567−Tumor ME009−Tumor TCGA−FS−A1ZQ TCGA−ER−A19F TCGA−EE−A20F TCGA−EE−A184 TCGA−D3−A3CF SKCM−JWCI−14−Tumor TCGA−EE−A3JD TCGA−EE−A2MT TCGA−EE−A29G TCGA−EE−A29C TCGA−EE−A29A SKCM−Ma−Mel−08a−Tumor SKCM−JWCI−WGS−34−Tumor SKCM−JWCI−WGS−21−Tumor TCGA−FS−A1ZW TCGA−FS−A1ZM TCGA−EE−A3J7 TCGA−EE−A2MS TCGA−EE−A2MQ TCGA−EE−A2GR TCGA−EE−A2GP TCGA−D3−A3ML TCGA−BF−A3DJ SKCM−13575−Tumor SKCM−JWCI−WGS−7−Tumor SKCM−JWCI−WGS−1−Tumor TCGA−EE−A20C SKCM−JWCI−WGS−22−Tumor TCGA−IH−A3EA TCGA−FS−A1ZC TCGA−EE−A2MJ TCGA−D3−A2JP TCGA−D3−A2JF TCGA−FS−A1ZK TCGA−ER−A19P TCGA−EE−A3J5 TCGA−EE−A3AA TCGA−EE−A2MU TCGA−EE−A2MD TCGA−EE−A2GO TCGA−EE−A2GI TCGA−EE−A2GC TCGA−EE−A29R TCGA−EE−A29M TCGA−DA−A1I0 TCGA−D3−A3MR TCGA−D3−A2J8 TCGA−D3−A1QB SKCM−Ma−Mel−67−Tumor SKCM−JWCI−WGS−5−Tumor SKCM−JWCI−WGS−39−Tumor SKCM−JWCI−WGS−25−Tumor TCGA−FS−A1ZA TCGA−EE−A3JA TCGA−EE−A3AF TCGA−EE−A2MN TCGA−EE−A2MC TCGA−EE−A2M5 TCGA−EE−A2GJ TCGA−EE−A2A0 TCGA−EE−A29X TCGA−EE−A29P TCGA−EE−A29L TCGA−EE−A29H TCGA−EE−A20H TCGA−EB−A299 TCGA−D3−A3MU TCGA−D3−A2JA SKCM−Ma−Mel−62−Tumor SKCM−Ma−Mel−37−Tumor SKCM−Ma−Mel−103b−Tumor SKCM−13600−Tumor Mel_BRAFi_02_PRE−Tumor ME045−Tumor ME029−Tumor ME014−Tumor

TCGA−FS−A1YY SKCM−13600−Tumor TCGA−D3−A1Q8 SKCM−JWCI−WGS−3−Tumor TCGA−EE−A29S TCGA−D3−A2JO TCGA−D3−A1Q6 TCGA−ER−A193 TCGA−DA−A1HY TCGA−D9−A1JW SKCM−Ma−Mel−91−Tumor TCGA−FS−A1ZK TCGA−EE−A2M8 SKCM−Ma−Mel−105−Tumor SKCM−JWCI−WGS−6−Tumor ME018−Tumor TCGA−GN−A263 TCGA−FS−A1Z3 TCGA−EE−A3JI TCGA−EE−A2M6 TCGA−D3−A3C3 TCGA−EE−A29V TCGA−ER−A2NE TCGA−EE−A3JD TCGA−EE−A2MK TCGA−EE−A29L TCGA−EE−A29H ME020−Tumor ME009−Tumor TCGA−FS−A1ZZ TCGA−ER−A19D TCGA−EE−A3AD TCGA−EE−A2GE TCGA−EE−A2GB TCGA−D3−A2JF SKCM−Ma−Mel−102−Tumor SKCM−JWCI−WGS−29−Tumor ME011−Tumor TCGA−EE−A3JA TCGA−EE−A3AG TCGA−EE−A2M5 TCGA−EE−A29M TCGA−EE−A17X TCGA−D3−A2JC SKCM−JWCI−WGS−39−Tumor TCGA−GN−A265 TCGA−FS−A1ZP TCGA−ER−A19N TCGA−ER−A195 TCGA−ER−A194 TCGA−EE−A3AC TCGA−EE−A2MT TCGA−EE−A2MS TCGA−EE−A2MJ TCGA−EE−A2MD TCGA−EE−A2MC TCGA−EE−A2GP TCGA−EE−A2A5 TCGA−EE−A183 TCGA−EE−A182 SKCM−Ma−Mel−86−Tumor SKCM−Ma−Mel−85−Tumor SKCM−Ma−Mel−48−Tumor SKCM−Ma−Mel−35−Tumor SKCM−Ma−Mel−119−Tumor SKCM−JWCI−WGS−7−Tumor SKCM−JWCI−WGS−43−Tumor SKCM−JWCI−WGS−38−Tumor SKCM−JWCI−WGS−36−Tumor SKCM−JWCI−WGS−35−Tumor SKCM−JWCI−WGS−34−Tumor SKCM−JWCI−WGS−25−Tumor SKCM−JWCI−WGS−13−Tumor SKCM−JWCI−WGS−1−Tumor SKCM−JWCI−27−Tumor SKCM−JWCI−14−Tumor SKCM−13561−Tumor

ERBB2 Regulates Cell Motility FDR = 3.5%, FDR nod = 4.6%

ERBB4

unknown CG mut

ERBB2 Activates PTK6 Signaling Signaling By ERBB4 FDR = 0.43%, FDR nod = 0.48%

TCGA−EB−A24D TCGA−EE−A29B TCGA−EE−A3J4 SKCM−Ma−Mel−114−Tumor TCGA−EE−A3AE TCGA−EE−A2GH TCGA−FS−A1ZE SKCM−Ma−Mel−63−Tumor ME012−Tumor TCGA−ER−A194 TCGA−EE−A181 TCGA−DA−A3F8 TCGA−DA−A1I5 SKCM−Ma−Mel−120−Tumor TCGA−GN−A267 TCGA−FS−A1ZZ TCGA−ER−A193 TCGA−EE−A29N TCGA−D3−A3MV SKCM−JWCI−WGS−43−Tumor TCGA−GN−A269 TCGA−ER−A19E TCGA−EE−A3AB TCGA−EE−A2MI TCGA−EE−A2M7 TCGA−EE−A29S TCGA−EE−A17X SKCM−UKRV−Mel−20−Tumor SKCM−Ma−Mel−102−Tumor SKCM−13473−Tumor TCGA−GN−A26C TCGA−EE−A2A5 TCGA−EE−A29T TCGA−EB−A1NK TCGA−DA−A1I7 TCGA−DA−A1HV TCGA−D3−A3C8 SKCM−Ma−Mel−54a−Tumor SKCM−Ma−Mel−27−Tumor SKCM−JWCI−WGS−35−Tumor SKCM−JWCI−WGS−23−Tumor SKCM−JWCI−27−Tumor TCGA−ER−A19F TCGA−EE−A3AD TCGA−EE−A2MF TCGA−DA−A3F3 TCGA−BF−A1Q0 SKCM−Ma−Mel−48−Tumor SKCM−JWCI−WGS−12−Tumor SKCM−13567−Tumor ME009−Tumor TCGA−FS−A1ZQ TCGA−EE−A20F TCGA−EE−A184 TCGA−D3−A3CF SKCM−JWCI−14−Tumor TCGA−EE−A3JD TCGA−EE−A2MT TCGA−EE−A29G TCGA−EE−A29C TCGA−EE−A29A SKCM−Ma−Mel−08a−Tumor SKCM−JWCI−WGS−34−Tumor SKCM−JWCI−WGS−21−Tumor TCGA−FS−A1ZW TCGA−FS−A1ZM TCGA−EE−A3J7 TCGA−EE−A2MS TCGA−EE−A2MQ TCGA−EE−A2GR TCGA−EE−A2GP TCGA−D3−A3ML TCGA−BF−A3DJ SKCM−13575−Tumor SKCM−JWCI−WGS−7−Tumor SKCM−JWCI−WGS−22−Tumor TCGA−EE−A20C SKCM−JWCI−WGS−1−Tumor TCGA−IH−A3EA TCGA−FS−A1ZC TCGA−EE−A2MJ TCGA−EE−A2MD TCGA−EE−A2GO TCGA−EE−A2GC TCGA−D3−A2JF TCGA−FS−A1ZK TCGA−ER−A19P TCGA−EE−A3J5 TCGA−EE−A3AA TCGA−EE−A2MU TCGA−EE−A2GI TCGA−EE−A29R TCGA−EE−A29M TCGA−EE−A29L TCGA−DA−A1I0 TCGA−D3−A3MR TCGA−D3−A2JP TCGA−D3−A2J8 TCGA−D3−A1QB SKCM−Ma−Mel−67−Tumor SKCM−JWCI−WGS−5−Tumor SKCM−JWCI−WGS−39−Tumor SKCM−JWCI−WGS−25−Tumor TCGA−FS−A1ZA TCGA−EE−A3JA TCGA−EE−A3AF TCGA−EE−A2MN TCGA−EE−A2MC TCGA−EE−A2M5 TCGA−EE−A2GJ TCGA−EE−A2A0 TCGA−EE−A29X TCGA−EE−A29P TCGA−EE−A29H TCGA−EE−A20H TCGA−EB−A299 TCGA−D3−A3MU TCGA−D3−A2JA SKCM−Ma−Mel−62−Tumor SKCM−Ma−Mel−37−Tumor SKCM−Ma−Mel−103b−Tumor SKCM−13600−Tumor Mel_BRAFi_02_PRE−Tumor ME045−Tumor ME029−Tumor ME014−Tumor

TCGA−D3−A3CB TCGA−EB−A24D TCGA−EE−A29B TCGA−EE−A3AE TCGA−EE−A2GH TCGA−ER−A194 TCGA−EE−A181 TCGA−DA−A3F8 TCGA−DA−A1I5 SKCM−Ma−Mel−120−Tumor TCGA−GN−A267 TCGA−FS−A1ZZ TCGA−ER−A193 TCGA−EE−A29N TCGA−D3−A3MV SKCM−JWCI−WGS−43−Tumor TCGA−GN−A269 TCGA−ER−A19E TCGA−EE−A3AB TCGA−EE−A2MI TCGA−EE−A2M7 TCGA−EE−A29S TCGA−EE−A17X SKCM−UKRV−Mel−20−Tumor SKCM−Ma−Mel−102−Tumor SKCM−13473−Tumor TCGA−EB−A1NK TCGA−GN−A26C TCGA−EE−A2A5 TCGA−EE−A29T TCGA−DA−A1I7 TCGA−DA−A1HV TCGA−D3−A3C8 SKCM−Ma−Mel−54a−Tumor SKCM−Ma−Mel−27−Tumor SKCM−JWCI−WGS−35−Tumor SKCM−JWCI−WGS−23−Tumor SKCM−JWCI−27−Tumor TCGA−EE−A3AD TCGA−EE−A2MF TCGA−DA−A3F3 TCGA−BF−A1Q0 SKCM−Ma−Mel−48−Tumor SKCM−JWCI−WGS−12−Tumor SKCM−13567−Tumor ME009−Tumor TCGA−FS−A1ZQ TCGA−ER−A19F TCGA−EE−A20F TCGA−EE−A184 TCGA−D3−A3CF SKCM−JWCI−14−Tumor TCGA−EE−A3JD TCGA−EE−A2MT TCGA−EE−A29G TCGA−EE−A29C TCGA−EE−A29A SKCM−Ma−Mel−08a−Tumor SKCM−JWCI−WGS−34−Tumor SKCM−JWCI−WGS−21−Tumor TCGA−FS−A1ZW TCGA−FS−A1ZM TCGA−EE−A3J7 TCGA−EE−A2MS TCGA−EE−A2MQ TCGA−EE−A2GR TCGA−EE−A2GP TCGA−D3−A3ML TCGA−BF−A3DJ SKCM−13575−Tumor SKCM−JWCI−WGS−7−Tumor TCGA−EE−A20C SKCM−JWCI−WGS−22−Tumor SKCM−JWCI−WGS−1−Tumor TCGA−IH−A3EA TCGA−FS−A1ZC TCGA−EE−A2MJ TCGA−D3−A2JF TCGA−FS−A1ZK TCGA−ER−A19P TCGA−EE−A3J5 TCGA−EE−A3AF TCGA−EE−A3AA TCGA−EE−A2MU TCGA−EE−A2MD TCGA−EE−A2GO TCGA−EE−A2GI TCGA−EE−A2GC TCGA−EE−A29R TCGA−EE−A29M TCGA−EE−A29L TCGA−DA−A1I0 TCGA−D3−A3MR TCGA−D3−A2JP TCGA−D3−A2J8 TCGA−D3−A1QB SKCM−Ma−Mel−67−Tumor SKCM−JWCI−WGS−5−Tumor SKCM−JWCI−WGS−39−Tumor SKCM−JWCI−WGS−25−Tumor TCGA−FS−A1ZA TCGA−EE−A3JA TCGA−EE−A2MN TCGA−EE−A2MC TCGA−EE−A2M5 TCGA−EE−A2GJ TCGA−EE−A2A0 TCGA−EE−A29X TCGA−EE−A29P TCGA−EE−A29H TCGA−EE−A20H TCGA−EB−A299 TCGA−D3−A3MU TCGA−D3−A2JA SKCM−Ma−Mel−62−Tumor SKCM−Ma−Mel−37−Tumor SKCM−Ma−Mel−103b−Tumor SKCM−13600−Tumor Mel_BRAFi_02_PRE−Tumor ME045−Tumor ME029−Tumor ME014−Tumor

VWF

unknown CG mut

MyD88 Dependent Cascade Initiated On Endosome TRAF6 Mediated Induction Of NFkB And MAP Kinases Upon TLR7/8 Or 9 Activation FDR = 0.85%, FDR nod = 2.7%

GRB2:SOS Provides Linkage To MAPK Signaling For Integrins FDR = 0.0059%, FDR nod = 0.0064%

known HCG mut known HCG mut TLR3


ERBB4 TLR4

NRG3

NRG1 TICAM1

EGF

CASP8

wt wt

EGFR

ERBB3 RIPK3

ERBB2

AREG LY96

CD14

HSP90AA1

BTC RIPK1

TGFA

FADD

EREG

NRG2 TICAM2

HBEGF

unknown CG mut

NRG3 ERBB4

EGF NRG3

NRG1 EGF

known HCG mut

known HCG mut

EGFR NRG1

wt

wt

ERBB2 EGFR

ERBB2

ERBB3

ERBB3

MEMO1

NRG2

NRG2

BTC

RHOA

DIAPH1 EREG

BTC

EREG HBEGF

HBEGF PTK6

TLR7

FGA

unknown CG mut

APBB1IP

FN1

known HCG mut

wt

TLR8

TLN1

ITGA2B

IRAK2

ITGB3

ECSIT

FGG

PTK2

SOS1

IRAK1

MYD88

FGB

GRB2

RAP1A

TRAF6

IRAK4

RAP1B

known HCG mut TLR9

wt

TCGA−EE−A183 TCGA−ER−A1A1 TCGA−EE−A3JD TCGA−D3−A3MR ME049−Tumor TCGA−FS−A1Z3 TCGA−EE−A2MQ TCGA−EE−A2GR TCGA−EE−A29T TCGA−GN−A26C TCGA−EE−A3JA TCGA−D3−A2JG SKCM−Ma−Mel−65−Tumor SKCM−JWCI−WGS−32−Tumor TCGA−ER−A194 TCGA−FS−A1YW TCGA−EB−A24D SKCM−Ma−Mel−91−Tumor SKCM−JWCI−WGS−35−Tumor SKCM−JWCI−WGS−25−Tumor TCGA−EE−A3J5 TCGA−EE−A2MM TCGA−EE−A2A2 TCGA−DA−A1I7 TCGA−DA−A1I4 SKCM−Ma−Mel−37−Tumor TCGA−GN−A263 TCGA−FS−A1Z0 TCGA−ER−A19F TCGA−EE−A2GM TCGA−EE−A181 TCGA−DA−A1HV TCGA−BF−A3DM SKCM−Ma−Mel−108−Tumor TCGA−EE−A2GC TCGA−D3−A3C7 SKCM−JWCI−WGS−12−Tumor SKCM−JWCI−WGS−1−Tumor ME017−Tumor TCGA−FS−A1YY TCGA−ER−A195 TCGA−EE−A3AB TCGA−EE−A2MJ TCGA−EE−A29R TCGA−DA−A1I1 TCGA−D3−A2JL TCGA−D3−A2JF SKCM−UKRV−Mel−20−Tumor SKCM−Ma−Mel−08a−Tumor TCGA−EE−A20C TCGA−FS−A1ZK TCGA−FS−A1ZC TCGA−ER−A19P TCGA−EE−A2GJ TCGA−FS−A1ZM TCGA−FS−A1ZA TCGA−ER−A19B TCGA−ER−A193 TCGA−EE−A2MC TCGA−EE−A17Y TCGA−DA−A3F8 TCGA−D3−A3C3 TCGA−BF−A1PX SKCM−Ma−Mel−54a−Tumor SKCM−Ma−Mel−103b−Tumor SKCM−JWCI−WGS−38−Tumor SKCM−JWCI−14−Tumor SKCM−13567−Tumor ME018−Tumor

TCGA−EE−A3AD TCGA−DA−A3F8 TCGA−DA−A1I4 TCGA−D3−A2J7 TCGA−ER−A19G SKCM−JWCI−WGS−32−Tumor SKCM−JWCI−WGS−18−Tumor ME033−Tumor TCGA−FS−A1ZQ SKCM−Ma−Mel−35−Tumor SKCM−JWCI−WGS−29−Tumor SKCM−13549−Tumor SKCM−13447−Tumor SKCM−Ma−Mel−94−Tumor TCGA−ER−A19D TCGA−D3−A1Q4 SKCM−Ma−Mel−59−Tumor SKCM−13567−Tumor ME045−Tumor TCGA−GN−A269 TCGA−EE−A2MP TCGA−EE−A2A5 TCGA−D3−A2JN ME030−Tumor TCGA−FS−A1ZW TCGA−GN−A265 TCGA−D3−A3C3 TCGA−D3−A1Q8 TCGA−D3−A1Q6 SKCM−JWCI−WGS−33−Tumor SKCM−JWCI−WGS−15−Tumor SKCM−13561−Tumor TCGA−FS−A1ZK TCGA−ER−A194 TCGA−EE−A2M5 TCGA−FS−A1ZP TCGA−EE−A3AE TCGA−EE−A29X TCGA−EE−A29N TCGA−DA−A3F5 TCGA−D9−A1JW SKCM−Ma−Mel−28−Tumor SKCM−Ma−Mel−08a−Tumor ME049−Tumor ME024−Tumor TCGA−ER−A19C TCGA−EE−A29V TCGA−BF−A1Q0 TCGA−GN−A26C TCGA−ER−A19N TCGA−ER−A19H TCGA−ER−A19A TCGA−EE−A3JB TCGA−EE−A3J4 TCGA−EE−A3AG TCGA−EE−A2MC TCGA−EE−A2GO TCGA−D3−A3C1 TCGA−D3−A2JO SKCM−Ma−Mel−85−Tumor SKCM−JWCI−WGS−21−Tumor ME014−Tumor ME009−Tumor TCGA−EE−A17X SKCM−JWCI−WGS−34−Tumor SKCM−JWCI−WGS−3−Tumor SKCM−JWCI−WGS−11−Tumor TCGA−ER−A1A1 TCGA−EE−A2MF TCGA−EE−A2GD TCGA−EE−A2GB TCGA−EE−A29Q TCGA−D3−A3MU TCGA−D3−A2J8 SKCM−Ma−Mel−55−Tumor SKCM−JWCI−WGS−42−Tumor ME034−Tumor ME012−Tumor ME011−Tumor SKCM−JWCI−27−Tumor TCGA−EE−A29S TCGA−FS−A1ZZ TCGA−EE−A3J5 TCGA−DA−A3F3 TCGA−FS−A1ZN TCGA−FS−A1ZC TCGA−FS−A1YY TCGA−ER−A19K TCGA−ER−A19F TCGA−ER−A193 TCGA−EE−A3JA TCGA−EE−A3J7 TCGA−EE−A3AC TCGA−EE−A2MI TCGA−EE−A2GR TCGA−EE−A182 TCGA−D3−A2JH TCGA−D3−A2JD SKCM−Ma−Mel−108−Tumor SKCM−Ma−Mel−05−Tumor SKCM−JWCI−WGS−5−Tumor SKCM−JWCI−WGS−38−Tumor SKCM−JWCI−WGS−24−Tumor SKCM−JWCI−WGS−22−Tumor TCGA−EE−A29M SKCM−JWCI−WGS−1−Tumor TCGA−D3−A3ML TCGA−D3−A2JF SKCM−JWCI−WGS−12−Tumor TCGA−EE−A3AF TCGA−EE−A3AA TCGA−EE−A2MS TCGA−EE−A29L TCGA−EE−A29B TCGA−EE−A181 SKCM−Ma−Mel−65−Tumor SKCM−JWCI−WGS−7−Tumor SKCM−JWCI−WGS−25−Tumor TCGA−HR−A2OG TCGA−FS−A1ZA TCGA−EE−A3JD TCGA−EE−A2GI TCGA−EE−A2GC TCGA−EE−A2A1 TCGA−EE−A20C TCGA−DA−A1I5 TCGA−DA−A1HV TCGA−D3−A3MR SKCM−Ma−Mel−103b−Tumor SKCM−JWCI−WGS−20−Tumor TCGA−FS−A1ZD TCGA−FS−A1ZB TCGA−ER−A19P TCGA−EE−A2MJ TCGA−EE−A2M6 TCGA−EE−A2GP TCGA−EE−A2GM TCGA−EE−A29C TCGA−EE−A180 TCGA−DA−A1I7 SKCM−Ma−Mel−92−Tumor SKCM−Ma−Mel−48−Tumor SKCM−Ma−Mel−114−Tumor SKCM−Ma−Mel−102−Tumor SKCM−JWCI−WGS−39−Tumor SKCM−JWCI−WGS−35−Tumor SKCM−JWCI−WGS−2−Tumor SKCM−JWCI−WGS−13−Tumor ME050−Tumor ME029−Tumor ME016−Tumor ME002−Tumor

PI3K Events In ERBB4 Signaling FDR = 1.1%, FDR nod = 0.02% P130Cas Linkage To MAPK Signaling For Integrins FDR = 0.0074%, FDR nod = 0.066%

TCGA−EB−A24D TCGA−EE−A29B TCGA−BF−A1Q0 TCGA−EE−A3AE TCGA−EE−A2GH SKCM−JWCI−WGS−12−Tumor TCGA−FS−A1ZN TCGA−EE−A2MG TCGA−EB−A3HV SKCM−JWCI−WGS−2−Tumor SKCM−13537−Tumor TCGA−FS−A1ZF TCGA−ER−A19E TCGA−EE−A3JE SKCM−Ma−Mel−76−Tumor SKCM−JWCI−WGS−15−Tumor ME041−Tumor TCGA−GN−A26C TCGA−EE−A3AD TCGA−EE−A2A5 TCGA−EE−A29T TCGA−EB−A1NK TCGA−DA−A1I7 TCGA−DA−A1HV TCGA−D3−A3C8 SKCM−Ma−Mel−54a−Tumor SKCM−Ma−Mel−27−Tumor SKCM−JWCI−WGS−35−Tumor SKCM−JWCI−WGS−23−Tumor SKCM−JWCI−27−Tumor TCGA−EE−A3JD TCGA−EE−A29G TCGA−EE−A29C TCGA−EE−A29A SKCM−Ma−Mel−08a−Tumor TCGA−FS−A1ZW TCGA−FS−A1ZM TCGA−EE−A3J7 TCGA−EE−A2MT TCGA−EE−A2MS TCGA−EE−A2MQ TCGA−EE−A2GR TCGA−EE−A2GP TCGA−D3−A3ML TCGA−BF−A3DJ SKCM−JWCI−WGS−34−Tumor SKCM−JWCI−WGS−21−Tumor SKCM−13575−Tumor SKCM−JWCI−WGS−7−Tumor TCGA−IH−A3EA TCGA−FS−A1ZC TCGA−D3−A2JF SKCM−JWCI−WGS−25−Tumor SKCM−JWCI−WGS−22−Tumor SKCM−JWCI−WGS−1−Tumor TCGA−ER−A19P TCGA−EE−A3J5 TCGA−EE−A3AA TCGA−EE−A2MU TCGA−EE−A2MJ TCGA−EE−A2MD TCGA−EE−A2M5 TCGA−EE−A2GC TCGA−EE−A29R TCGA−EE−A29M TCGA−EE−A29L TCGA−EE−A20H TCGA−EE−A20C TCGA−DA−A1I0 TCGA−D3−A3MR TCGA−D3−A2J8 SKCM−Ma−Mel−67−Tumor SKCM−JWCI−WGS−39−Tumor TCGA−FS−A1ZK TCGA−FS−A1ZA TCGA−EE−A3JA TCGA−EE−A3AF TCGA−EE−A2MN TCGA−EE−A2MC TCGA−EE−A2GO TCGA−EE−A2GJ TCGA−EE−A2GI TCGA−EE−A2A0 TCGA−EE−A29X TCGA−EE−A29P TCGA−EE−A29H TCGA−EB−A299 TCGA−D3−A3MU TCGA−D3−A2JP TCGA−D3−A2JA TCGA−D3−A1QB SKCM−Ma−Mel−62−Tumor SKCM−Ma−Mel−37−Tumor SKCM−Ma−Mel−103b−Tumor SKCM−JWCI−WGS−5−Tumor SKCM−13600−Tumor Mel_BRAFi_02_PRE−Tumor ME045−Tumor ME029−Tumor ME014−Tumor

SKCM−JWCI−14−Tumor TCGA−DA−A3F8 TCGA−DA−A1I4 TCGA−D3−A2J7 TCGA−IH−A3EA TCGA−EE−A20F SKCM−Ma−Mel−120−Tumor SKCM−JWCI−WGS−29−Tumor TCGA−FS−A1ZQ SKCM−Ma−Mel−35−Tumor SKCM−13549−Tumor SKCM−13447−Tumor SKCM−Ma−Mel−94−Tumor TCGA−ER−A19D TCGA−D3−A1Q4 SKCM−Ma−Mel−59−Tumor SKCM−13567−Tumor TCGA−GN−A269 TCGA−EE−A2MP TCGA−EE−A2A5 TCGA−D3−A2JN ME045−Tumor ME030−Tumor TCGA−FS−A1ZW TCGA−GN−A265 TCGA−D3−A3C3 TCGA−D3−A1Q8 TCGA−D3−A1Q6 SKCM−JWCI−WGS−33−Tumor SKCM−JWCI−WGS−15−Tumor SKCM−13561−Tumor TCGA−FS−A1ZK TCGA−ER−A194 TCGA−FS−A1ZP TCGA−EE−A3AE TCGA−EE−A2M5 TCGA−EE−A29X TCGA−EE−A29N TCGA−DA−A3F5 TCGA−D9−A1JW SKCM−Ma−Mel−28−Tumor SKCM−Ma−Mel−08a−Tumor ME049−Tumor ME024−Tumor TCGA−ER−A19C TCGA−EE−A29V TCGA−GN−A26C TCGA−ER−A19N TCGA−ER−A19H TCGA−ER−A19A TCGA−EE−A3JB TCGA−EE−A3J4 TCGA−EE−A3AG TCGA−EE−A2MC TCGA−EE−A2GO TCGA−D3−A3C1 TCGA−D3−A2JO TCGA−BF−A1Q0 SKCM−Ma−Mel−85−Tumor SKCM−JWCI−WGS−21−Tumor ME014−Tumor ME009−Tumor TCGA−EE−A17X SKCM−JWCI−WGS−34−Tumor SKCM−JWCI−WGS−3−Tumor SKCM−JWCI−WGS−11−Tumor TCGA−ER−A1A1 TCGA−EE−A2MF TCGA−EE−A2GD TCGA−EE−A2GB TCGA−EE−A29Q TCGA−D3−A3MU TCGA−D3−A2J8 SKCM−Ma−Mel−55−Tumor SKCM−JWCI−WGS−42−Tumor ME034−Tumor ME012−Tumor ME011−Tumor SKCM−JWCI−27−Tumor TCGA−EE−A29S TCGA−FS−A1ZZ TCGA−EE−A3J5 TCGA−DA−A3F3 TCGA−FS−A1ZN TCGA−FS−A1ZC TCGA−FS−A1YY TCGA−ER−A19K TCGA−ER−A19F TCGA−ER−A193 TCGA−EE−A3JA TCGA−EE−A3J7 TCGA−EE−A3AC TCGA−EE−A2MI TCGA−EE−A2GR TCGA−EE−A182 TCGA−D3−A2JH TCGA−D3−A2JD SKCM−Ma−Mel−108−Tumor SKCM−Ma−Mel−05−Tumor SKCM−JWCI−WGS−5−Tumor SKCM−JWCI−WGS−38−Tumor SKCM−JWCI−WGS−24−Tumor SKCM−JWCI−WGS−22−Tumor SKCM−JWCI−WGS−1−Tumor TCGA−EE−A2MS TCGA−EE−A29M TCGA−D3−A3ML TCGA−D3−A2JF SKCM−JWCI−WGS−12−Tumor TCGA−EE−A3AF TCGA−EE−A3AA TCGA−EE−A29L TCGA−EE−A29B TCGA−EE−A181 SKCM−Ma−Mel−65−Tumor SKCM−JWCI−WGS−7−Tumor SKCM−JWCI−WGS−25−Tumor TCGA−HR−A2OG TCGA−FS−A1ZA TCGA−EE−A3JD TCGA−EE−A2MJ TCGA−EE−A2GC TCGA−EE−A2A1 TCGA−EE−A20C TCGA−DA−A1I5 TCGA−DA−A1HV TCGA−D3−A3MR SKCM−Ma−Mel−103b−Tumor TCGA−FS−A1ZD TCGA−FS−A1ZB TCGA−ER−A19P TCGA−EE−A2M6 TCGA−EE−A2GP TCGA−EE−A2GM TCGA−EE−A2GI TCGA−EE−A29C TCGA−EE−A180 TCGA−DA−A1I7 SKCM−Ma−Mel−92−Tumor SKCM−Ma−Mel−48−Tumor SKCM−Ma−Mel−114−Tumor SKCM−Ma−Mel−102−Tumor SKCM−JWCI−WGS−39−Tumor SKCM−JWCI−WGS−35−Tumor SKCM−JWCI−WGS−20−Tumor SKCM−JWCI−WGS−2−Tumor SKCM−JWCI−WGS−13−Tumor ME050−Tumor ME029−Tumor ME016−Tumor ME002−Tumor

wt PRKCQ

Signalling To P38 Via RIT And RIN FDR = 3.9e−12%, FDR nod = 7.5e−05%

unknown CG mut

Raf Activation Signaling (through RasGRP) ( CD4 T Cell Receptor Signaling (ERK Cascade) ) Raf Activation Signaling (through RasGRP) ( CD4 T Cell Receptor Signaling ) FDR = 3.9e−12%, FDR nod = 1.1%

TCGA−EE−A185 TCGA−BF−A1PZ TCGA−FS−A1ZW TCGA−EE−A182 SKCM−JWCI−WGS−7−Tumor TCGA−EE−A2MS TCGA−EE−A29S TCGA−DA−A3F3 SKCM−Ma−Mel−65−Tumor TCGA−EE−A3JA TCGA−EE−A3J5 TCGA−EE−A2GI TCGA−EE−A20I TCGA−EE−A17Z TCGA−EE−A17X SKCM−Ma−Mel−102−Tumor TCGA−ER−A193 TCGA−GN−A263 TCGA−FS−A1ZZ TCGA−ER−A19E TCGA−EE−A3AD TCGA−EE−A3AA TCGA−EE−A2GT TCGA−EE−A2GO TCGA−EE−A2GH TCGA−EE−A29P TCGA−EE−A29M TCGA−EE−A183 TCGA−DA−A1I7 TCGA−D3−A3MU TCGA−D3−A3MR TCGA−D3−A2JK TCGA−D3−A1Q7 TCGA−BF−A3DL TCGA−BF−A1PU SKCM−UKRV−Mel−24−Tumor SKCM−Ma−Mel−85−Tumor SKCM−Ma−Mel−55−Tumor SKCM−JWCI−14−Tumor ME043−Tumor ME029−Tumor TCGA−IH−A3EA TCGA−HR−A2OH TCGA−GN−A269 TCGA−GN−A265 TCGA−GN−A262 TCGA−GF−A2C7 TCGA−FS−A1ZS TCGA−FS−A1ZR TCGA−FS−A1ZN TCGA−FS−A1ZM TCGA−FS−A1ZH TCGA−FS−A1ZF TCGA−FS−A1ZD TCGA−FS−A1ZC TCGA−FS−A1Z7 TCGA−FS−A1YY TCGA−FS−A1YX TCGA−ER−A2NG TCGA−ER−A2ND TCGA−ER−A2NC TCGA−ER−A19S TCGA−ER−A19Q TCGA−ER−A19P TCGA−ER−A19O TCGA−ER−A19K TCGA−ER−A19J TCGA−ER−A19H TCGA−ER−A19G TCGA−ER−A19F TCGA−ER−A19C TCGA−ER−A19B TCGA−ER−A198 TCGA−EE−A3JH TCGA−EE−A3JE TCGA−EE−A3JD TCGA−EE−A3JB TCGA−EE−A3J4 TCGA−EE−A3J3 TCGA−EE−A3AH TCGA−EE−A3AG TCGA−EE−A3AF TCGA−EE−A3AB TCGA−EE−A2MQ TCGA−EE−A2MP TCGA−EE−A2MK TCGA−EE−A2MH TCGA−EE−A2MG TCGA−EE−A2ME TCGA−EE−A2M8 TCGA−EE−A2M7 TCGA−EE−A2M6 TCGA−EE−A2M5 TCGA−EE−A2GS TCGA−EE−A2GM TCGA−EE−A2GJ TCGA−EE−A2GE TCGA−EE−A2GC TCGA−EE−A2GB TCGA−EE−A2A6 TCGA−EE−A2A0 TCGA−EE−A29W TCGA−EE−A29T TCGA−EE−A29N TCGA−EE−A29H TCGA−EE−A29C TCGA−EE−A29A TCGA−EE−A20H TCGA−EE−A20F TCGA−EE−A20B TCGA−EE−A181 TCGA−EE−A17Y TCGA−EB−A3HV TCGA−EB−A299 TCGA−EB−A24D TCGA−EB−A24C TCGA−DA−A3F8 TCGA−DA−A3F5 TCGA−DA−A1IB TCGA−DA−A1I8 TCGA−DA−A1I5 TCGA−DA−A1I4 TCGA−DA−A1I2 TCGA−DA−A1I0 TCGA−DA−A1HY TCGA−DA−A1HW TCGA−D9−A1JX TCGA−D9−A1JW TCGA−D9−A148 TCGA−D3−A3MO TCGA−D3−A3CE TCGA−D3−A3CB TCGA−D3−A3C7 TCGA−D3−A3C6 TCGA−D3−A3C3 TCGA−D3−A3C1 TCGA−D3−A2JP TCGA−D3−A2JN TCGA−D3−A2JH TCGA−D3−A2JG TCGA−D3−A2JD TCGA−D3−A2JA TCGA−D3−A2J9 TCGA−D3−A2J7 TCGA−D3−A1QA TCGA−D3−A1Q9 TCGA−D3−A1Q6 TCGA−D3−A1Q5 TCGA−D3−A1Q4 TCGA−BF−A3DN TCGA−BF−A3DM TCGA−BF−A3DJ TCGA−BF−A1PX SKCM−UKRV−Mel−6−Tumor SKCM−UKRV−Mel−20−Tumor SKCM−Ma−Mel−92−Tumor SKCM−Ma−Mel−86−Tumor SKCM−Ma−Mel−67−Tumor SKCM−Ma−Mel−63−Tumor SKCM−Ma−Mel−59−Tumor SKCM−Ma−Mel−54a−Tumor SKCM−Ma−Mel−48−Tumor SKCM−Ma−Mel−36−Tumor SKCM−Ma−Mel−35−Tumor SKCM−Ma−Mel−19−Tumor SKCM−Ma−Mel−16−Tumor SKCM−Ma−Mel−122−Tumor SKCM−Ma−Mel−120−Tumor SKCM−Ma−Mel−108−Tumor SKCM−Ma−Mel−04−Tumor SKCM−JWCI−WGS−8−Tumor SKCM−JWCI−WGS−6−Tumor SKCM−JWCI−WGS−5−Tumor SKCM−JWCI−WGS−42−Tumor SKCM−JWCI−WGS−4−Tumor SKCM−JWCI−WGS−39−Tumor SKCM−JWCI−WGS−38−Tumor SKCM−JWCI−WGS−37−Tumor SKCM−JWCI−WGS−36−Tumor SKCM−JWCI−WGS−35−Tumor SKCM−JWCI−WGS−33−Tumor SKCM−JWCI−WGS−32−Tumor SKCM−JWCI−WGS−3−Tumor SKCM−JWCI−WGS−25−Tumor SKCM−JWCI−WGS−24−Tumor SKCM−JWCI−WGS−23−Tumor SKCM−JWCI−WGS−22−Tumor SKCM−JWCI−WGS−21−Tumor SKCM−JWCI−WGS−2−Tumor SKCM−JWCI−WGS−19−Tumor SKCM−JWCI−WGS−18−Tumor SKCM−JWCI−WGS−15−Tumor SKCM−JWCI−WGS−13−Tumor SKCM−JWCI−WGS−12−Tumor SKCM−JWCI−WGS−11−Tumor SKCM−13600−Tumor SKCM−13591−Tumor SKCM−13567−Tumor SKCM−13561−Tumor SKCM−13549−Tumor SKCM−13537−Tumor SKCM−13473−Tumor SKCM−13468−Tumor SKCM−13456−Tumor SKCM−13447−Tumor Mel−BRAFi−03−Tumor Mel_BRAFi_02_PRE−Tumor ME050−Tumor ME048−Tumor ME045−Tumor ME041−Tumor ME037−Tumor ME034−Tumor ME033−Tumor ME024−Tumor ME021−Tumor ME020−Tumor ME017−Tumor ME016−Tumor ME015−Tumor ME012−Tumor ME009−Tumor

SKCM−13531−Tumor TCGA−FS−A1ZK TCGA−ER−A194 TCGA−EE−A2MT TCGA−EE−A2MS TCGA−EE−A29B TCGA−D3−A2JF TCGA−EE−A2MJ TCGA−EE−A2GI SKCM−JWCI−WGS−7−Tumor SKCM−JWCI−WGS−1−Tumor TCGA−EE−A2MF TCGA−EE−A20C TCGA−FS−A1ZW TCGA−ER−A19D TCGA−EE−A2MD TCGA−EE−A29S TCGA−EE−A17X TCGA−D3−A2JL TCGA−D3−A2J8 TCGA−BF−A1PV SKCM−Ma−Mel−65−Tumor SKCM−JWCI−WGS−29−Tumor ME014−Tumor TCGA−HR−A2OG TCGA−GN−A268 TCGA−GN−A267 TCGA−FS−A1ZY TCGA−FS−A1ZT TCGA−FS−A1ZQ TCGA−FS−A1ZP TCGA−FS−A1ZE TCGA−FS−A1ZB TCGA−FS−A1ZA TCGA−FS−A1Z3 TCGA−FS−A1Z0 TCGA−FS−A1YW TCGA−ER−A2NH TCGA−ER−A2NE TCGA−ER−A2NB TCGA−ER−A19N TCGA−ER−A199 TCGA−ER−A195 TCGA−EE−A3JI TCGA−EE−A3JA TCGA−EE−A3J8 TCGA−EE−A3J7 TCGA−EE−A3AC TCGA−EE−A2MU TCGA−EE−A2MN TCGA−EE−A2MM TCGA−EE−A2ML TCGA−EE−A2MC TCGA−EE−A2GU TCGA−EE−A2GP TCGA−EE−A2GN TCGA−EE−A2GL TCGA−EE−A2GD TCGA−EE−A2A5 TCGA−EE−A2A2 TCGA−EE−A2A1 TCGA−EE−A29X TCGA−EE−A29V TCGA−EE−A29R TCGA−EE−A29Q TCGA−EE−A29L TCGA−EE−A29G TCGA−EE−A185 TCGA−EE−A184 TCGA−EB−A1NK TCGA−DA−A3F3 TCGA−DA−A1I1 TCGA−DA−A1HV TCGA−D3−A3MV TCGA−D3−A3ML TCGA−D3−A2JO TCGA−D3−A1QB TCGA−D3−A1Q8 TCGA−D3−A1Q1 TCGA−BF−A1PZ SKCM−Ma−Mel−94−Tumor SKCM−Ma−Mel−91−Tumor SKCM−Ma−Mel−79−Tumor SKCM−Ma−Mel−53−Tumor SKCM−Ma−Mel−37−Tumor SKCM−Ma−Mel−28−Tumor SKCM−Ma−Mel−119−Tumor SKCM−Ma−Mel−105−Tumor SKCM−Ma−Mel−103b−Tumor SKCM−Ma−Mel−102−Tumor SKCM−Ma−Mel−05−Tumor SKCM−JWCI−WGS−43−Tumor SKCM−JWCI−WGS−26−Tumor SKCM−JWCI−27−Tumor SKCM−13575−Tumor SKCM−13463−Tumor ME049−Tumor ME044−Tumor ME035−Tumor ME030−Tumor ME018−Tumor ME011−Tumor ME010−Tumor ME002−Tumor ME001−Tumor TCGA−FS−A1ZZ TCGA−EE−A2GC SKCM−Ma−Mel−48−Tumor SKCM−JWCI−WGS−12−Tumor ME009−Tumor TCGA−GN−A269 TCGA−FS−A1YY TCGA−ER−A2NC TCGA−ER−A19P TCGA−ER−A19K TCGA−ER−A19E TCGA−EE−A3AA TCGA−EE−A2GO TCGA−EE−A2GM TCGA−EE−A2GJ TCGA−EE−A29N TCGA−EE−A20F TCGA−D9−A1JW TCGA−D3−A3C7 TCGA−BF−A3DL SKCM−Ma−Mel−92−Tumor SKCM−Ma−Mel−67−Tumor SKCM−Ma−Mel−35−Tumor SKCM−JWCI−WGS−39−Tumor SKCM−JWCI−WGS−32−Tumor SKCM−JWCI−WGS−3−Tumor SKCM−JWCI−WGS−25−Tumor SKCM−JWCI−14−Tumor ME033−Tumor ME021−Tumor TCGA−IH−A3EA TCGA−HR−A2OH TCGA−GN−A265 TCGA−GN−A263 TCGA−GN−A262 TCGA−GF−A2C7 TCGA−FS−A1ZS TCGA−FS−A1ZR TCGA−FS−A1ZN TCGA−FS−A1ZM TCGA−FS−A1ZH TCGA−FS−A1ZF TCGA−FS−A1ZD TCGA−FS−A1ZC TCGA−FS−A1Z7 TCGA−FS−A1YX TCGA−ER−A2NG TCGA−ER−A2ND TCGA−ER−A19S TCGA−ER−A19Q TCGA−ER−A19O TCGA−ER−A19J TCGA−ER−A19H TCGA−ER−A19G TCGA−ER−A19F TCGA−ER−A19C TCGA−ER−A19B TCGA−ER−A198 TCGA−ER−A193 TCGA−EE−A3JH TCGA−EE−A3JE TCGA−EE−A3JD TCGA−EE−A3JB TCGA−EE−A3J4 TCGA−EE−A3J3 TCGA−EE−A3AH TCGA−EE−A3AG TCGA−EE−A3AF TCGA−EE−A3AD TCGA−EE−A3AB TCGA−EE−A2MQ TCGA−EE−A2MP TCGA−EE−A2MK TCGA−EE−A2MH TCGA−EE−A2MG TCGA−EE−A2ME TCGA−EE−A2M8 TCGA−EE−A2M7 TCGA−EE−A2M6 TCGA−EE−A2M5 TCGA−EE−A2GT TCGA−EE−A2GS TCGA−EE−A2GH TCGA−EE−A2GE TCGA−EE−A2GB TCGA−EE−A2A6 TCGA−EE−A2A0 TCGA−EE−A29W TCGA−EE−A29T TCGA−EE−A29P TCGA−EE−A29M TCGA−EE−A29H TCGA−EE−A29C TCGA−EE−A29A TCGA−EE−A20H TCGA−EE−A20B TCGA−EE−A183 TCGA−EE−A181 TCGA−EE−A17Y TCGA−EB−A3HV TCGA−EB−A299 TCGA−EB−A24D TCGA−EB−A24C TCGA−DA−A3F8 TCGA−DA−A3F5 TCGA−DA−A1IB TCGA−DA−A1I8 TCGA−DA−A1I7 TCGA−DA−A1I5 TCGA−DA−A1I4 TCGA−DA−A1I2 TCGA−DA−A1I0 TCGA−DA−A1HY TCGA−DA−A1HW TCGA−D9−A1JX TCGA−D9−A148 TCGA−D3−A3MU TCGA−D3−A3MR TCGA−D3−A3MO TCGA−D3−A3CE TCGA−D3−A3CB TCGA−D3−A3C6 TCGA−D3−A3C3 TCGA−D3−A3C1 TCGA−D3−A2JP TCGA−D3−A2JN TCGA−D3−A2JK TCGA−D3−A2JH TCGA−D3−A2JG TCGA−D3−A2JD TCGA−D3−A2JA TCGA−D3−A2J9 TCGA−D3−A2J7 TCGA−D3−A1QA TCGA−D3−A1Q9 TCGA−D3−A1Q7 TCGA−D3−A1Q6 TCGA−D3−A1Q5 TCGA−D3−A1Q4 TCGA−BF−A3DN TCGA−BF−A3DM TCGA−BF−A3DJ TCGA−BF−A1PX TCGA−BF−A1PU SKCM−UKRV−Mel−6−Tumor SKCM−UKRV−Mel−24−Tumor SKCM−UKRV−Mel−20−Tumor SKCM−Ma−Mel−86−Tumor SKCM−Ma−Mel−85−Tumor SKCM−Ma−Mel−63−Tumor SKCM−Ma−Mel−59−Tumor SKCM−Ma−Mel−55−Tumor SKCM−Ma−Mel−54a−Tumor SKCM−Ma−Mel−36−Tumor SKCM−Ma−Mel−19−Tumor SKCM−Ma−Mel−16−Tumor SKCM−Ma−Mel−122−Tumor SKCM−Ma−Mel−120−Tumor SKCM−Ma−Mel−108−Tumor SKCM−Ma−Mel−04−Tumor SKCM−JWCI−WGS−8−Tumor SKCM−JWCI−WGS−6−Tumor SKCM−JWCI−WGS−5−Tumor SKCM−JWCI−WGS−42−Tumor SKCM−JWCI−WGS−4−Tumor SKCM−JWCI−WGS−38−Tumor SKCM−JWCI−WGS−37−Tumor SKCM−JWCI−WGS−36−Tumor SKCM−JWCI−WGS−35−Tumor SKCM−JWCI−WGS−33−Tumor SKCM−JWCI−WGS−24−Tumor SKCM−JWCI−WGS−23−Tumor SKCM−JWCI−WGS−22−Tumor SKCM−JWCI−WGS−21−Tumor SKCM−JWCI−WGS−2−Tumor SKCM−JWCI−WGS−19−Tumor SKCM−JWCI−WGS−18−Tumor SKCM−JWCI−WGS−15−Tumor SKCM−JWCI−WGS−13−Tumor SKCM−JWCI−WGS−11−Tumor SKCM−13600−Tumor SKCM−13591−Tumor SKCM−13567−Tumor SKCM−13561−Tumor SKCM−13549−Tumor SKCM−13537−Tumor SKCM−13473−Tumor SKCM−13468−Tumor SKCM−13456−Tumor SKCM−13447−Tumor Mel−BRAFi−03−Tumor Mel_BRAFi_02_PRE−Tumor ME050−Tumor ME048−Tumor ME045−Tumor ME043−Tumor ME041−Tumor ME037−Tumor ME034−Tumor ME029−Tumor ME024−Tumor ME020−Tumor ME017−Tumor ME016−Tumor ME015−Tumor ME012−Tumor

IRF3 Mediated Activation Of Type 1 IFN FDR = 1.2e−06%, FDR nod = 1.2e−05% IL 6 Type Cytokine Receptor Ligand Interactions FDR = 1.7%, FDR nod = 4.6%


ERBB4 VWF

FGA

wt wt

PIK3CA ITGA2B

NRG2 PTK2

EREG CRK

HBEGF RAP1B

BRAF BRAF

known HCG mut

RIT2 ARAF


NLRP4 LIFR


IL12RB2

IL27

wt wt

ZBP1

IL6ST

OSM

CRLF1

TBK1

EBI3

IL12A

CNTF

IL11

CLCF1

CNTFR

IRF3

CTF1

TMEM173

IL11RA

LIF

wt NTRK1

known HCG mut NRG3 APBB1IP

FN1

TLN1

NRG1

ITGB3

FGG

PIK3R1

BCAR1

FGB

BTC

RAP1A

unknown CG mut

NRAS

known HCG mut

known HCG mut

RASGRP1

KRAS

NGF

HRAS

RAF1

RIT1

OSMR

IL27RA

JAK2

TYK2

DTX4 JAK1

TCGA−EE−A3AA ME017−Tumor TCGA−EE−A2GN TCGA−BF−A1PV TCGA−ER−A19P TCGA−EE−A2MS TCGA−EE−A20H TCGA−GN−A267 TCGA−FS−A1Z3 TCGA−ER−A19G TCGA−EE−A2MN TCGA−DA−A1HY SKCM−UKRV−Mel−24−Tumor SKCM−Ma−Mel−48−Tumor TCGA−FS−A1ZK TCGA−D9−A1JX SKCM−Ma−Mel−114−Tumor SKCM−Ma−Mel−08a−Tumor SKCM−JWCI−WGS−43−Tumor SKCM−JWCI−WGS−42−Tumor SKCM−13543−Tumor TCGA−ER−A193 TCGA−EE−A2M5 TCGA−EE−A29V TCGA−EE−A182 TCGA−D3−A3C8 SKCM−Ma−Mel−85−Tumor SKCM−Ma−Mel−65−Tumor SKCM−JWCI−WGS−12−Tumor SKCM−JWCI−WGS−1−Tumor TCGA−GN−A26C TCGA−GN−A269 TCGA−FS−A1ZZ TCGA−FS−A1ZW TCGA−FS−A1ZP TCGA−FS−A1YY TCGA−ER−A2ND TCGA−ER−A2NC TCGA−ER−A19K TCGA−ER−A19D TCGA−ER−A19A TCGA−EE−A3AG TCGA−EE−A3AE TCGA−EE−A2MJ TCGA−EE−A2MI TCGA−EE−A2MF TCGA−EE−A2GT TCGA−EE−A2GR TCGA−EE−A2GO TCGA−EE−A2GJ TCGA−EE−A2GB TCGA−EE−A29T TCGA−EE−A29Q TCGA−EE−A29M TCGA−EE−A29L TCGA−EE−A183 TCGA−EE−A181 TCGA−EB−A24D TCGA−DA−A1IC TCGA−DA−A1I5 TCGA−DA−A1I0 TCGA−DA−A1HV TCGA−D9−A148 TCGA−D3−A3CB TCGA−D3−A2JA SKCM−Ma−Mel−92−Tumor SKCM−Ma−Mel−36−Tumor SKCM−Ma−Mel−119−Tumor SKCM−JWCI−WGS−32−Tumor SKCM−JWCI−WGS−22−Tumor SKCM−JWCI−WGS−13−Tumor SKCM−JWCI−14−Tumor ME032−Tumor ME024−Tumor ME014−Tumor

ME030−Tumor ME012−Tumor TCGA−D3−A3MR TCGA−EE−A2MD TCGA−D3−A3BZ TCGA−EE−A2MT TCGA−BF−A3DJ TCGA−EB−A24D TCGA−D3−A2JA TCGA−GN−A263 TCGA−EB−A299 TCGA−BF−A1PX TCGA−GN−A264 TCGA−EE−A3AD TCGA−D3−A3MV TCGA−ER−A198 TCGA−EE−A2MF TCGA−D3−A2JN TCGA−EE−A3AC SKCM−Ma−Mel−55−Tumor SKCM−Ma−Mel−102−Tumor SKCM−Ma−Mel−53−Tumor SKCM−Ma−Mel−36−Tumor SKCM−JWCI−WGS−35−Tumor SKCM−JWCI−WGS−32−Tumor ME009−Tumor TCGA−EE−A2MQ TCGA−EE−A2GN TCGA−EE−A29R TCGA−D3−A2JF SKCM−UKRV−Mel−20−Tumor SKCM−JWCI−WGS−3−Tumor TCGA−ER−A19E TCGA−EE−A181 TCGA−FS−A1ZB TCGA−D3−A2JH SKCM−Ma−Mel−54a−Tumor SKCM−JWCI−WGS−12−Tumor SKCM−JWCI−27−Tumor SKCM−13567−Tumor ME001−Tumor TCGA−ER−A19P SKCM−Ma−Mel−67−Tumor TCGA−GN−A26C TCGA−GN−A26A TCGA−ER−A19O TCGA−EE−A3JB TCGA−EE−A3J5 TCGA−EE−A185 TCGA−DA−A1IC TCGA−D9−A1JX SKCM−JWCI−WGS−4−Tumor TCGA−ER−A193 SKCM−Ma−Mel−48−Tumor SKCM−JWCI−WGS−6−Tumor TCGA−EE−A3J7 TCGA−EE−A20C TCGA−D3−A2JP TCGA−D3−A1QA TCGA−FS−A1YY TCGA−ER−A2NC TCGA−ER−A19N TCGA−EE−A3JA TCGA−EE−A2ML TCGA−EE−A2GR TCGA−EE−A29B TCGA−EE−A29A TCGA−D3−A3C8 TCGA−D3−A3C1 TCGA−D3−A2JC SKCM−JWCI−WGS−7−Tumor SKCM−JWCI−WGS−21−Tumor ME020−Tumor TCGA−EE−A3AA TCGA−EE−A3JD TCGA−EE−A2MJ TCGA−EE−A2M5 TCGA−EE−A2A2 TCGA−EE−A29M TCGA−EE−A182 SKCM−Ma−Mel−85−Tumor SKCM−JWCI−WGS−1−Tumor TCGA−EE−A3AH TCGA−EE−A3AG TCGA−EE−A2MS TCGA−EE−A2GU TCGA−EE−A29L TCGA−DA−A1HV TCGA−D3−A3ML SKCM−Ma−Mel−65−Tumor SKCM−Ma−Mel−35−Tumor SKCM−Ma−Mel−119−Tumor SKCM−JWCI−WGS−5−Tumor TCGA−IH−A3EA TCGA−GN−A269 TCGA−GN−A268 TCGA−FS−A1Z4 TCGA−ER−A2NH TCGA−ER−A194 TCGA−EE−A3J4 TCGA−EE−A2MI TCGA−EE−A2MG TCGA−EE−A2M8 TCGA−EE−A2GL TCGA−EE−A2A0 TCGA−EE−A184 TCGA−EE−A183 TCGA−EE−A17Z TCGA−DA−A1I1 TCGA−D3−A2JD TCGA−BF−A1PV SKCM−JWCI−WGS−25−Tumor ME037−Tumor ME033−Tumor ME014−Tumor