Peak exercise response in relation to tissue ... - Semantic Scholar
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Peak exercise response in relation to tissue ... - Semantic Scholar
composition and peak exercise performance was executed in 62 patients with clini- cally stable .... FFM depletion using FFM adjusted for ideal body weight.
Eur Respir J 1997; 10: 2807–2813 DOI: 10.1183/09031936.97.10122807 Printed in UK - all rights reserved
Peak exercise response in relation to tissue depletion in patients with chronic obstructive pulmonary disease E.M. Baarends*, A.M.W.J. Schols*, R. Mostert**, E.F.M. Wouters* aa
Peak exercise response in relation to tissue depletion in patients with chronic obstructive pulmonary disease. E.M. Baarends, A.M.W.J. Schols, R. Mostert, E.F.M. Wouters. ERS Journals Ltd 1997. ABSTRACT: In several studies a correlation between body weight and peak exercise capacity has been found in patients with chronic obstructive pulmonary disease (COPD). In the present study a thorough analysis of the relationship between body composition and peak exercise performance was executed in 62 patients with clinically stable COPD. This was based on the hypothesis that particularly muscle mass, as the largest constituent of both fat-free mass (FFM) and body cell mass, is related to exercise capacity. Body composition was assessed using deuterium and bromide dilution techniques, to measure total body water (TBW) and extracellular water. From these measurements FFM:TBW/0.73, the ratio of ECW/intracellular water (ICW) and ICW-index (ICW/height2) were calculated. Peak exercise performance was measured using an incremental cycle ergometry test. The transfer factor of the lung for carbon monoxide (TL,CO) intrathoracic gas volume (ITGV), maximal expiratory and inspiratory mouth pressure, forced expiratory volume in one second (FEV1), FFM-index (FFM/height2), body mass index (weight/ height2) and ICW-index correlated strongly (p44%, females: three patients >48%). Correlation between lung function, body composition and peak V 'O2
Data analysis The characteristics of the patients are given as mean± SD. Differences between groups were calculated with an unpaired student t-test. Stepwise regression analysis was
In table 2 the correlation coefficients between peak V 'O2 and lung function under resting conditions, and measurements of body composition are shown. Peak V 'O2 correlated best with TL,CO (% pred: r=0.55, p
