Persistent hyperfibrinogenemia in acute ischemic stroke / transient ...
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Persistent hyperfibrinogenemia in acute ischemic stroke / transient ...
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Persistent hyperfibrinogenemia in acute ischemic stroke / transient ischemic attack (TIA) Shani Shenhar-Tsarfaty1, Einor Ben Assayag1, Irena Bova1, Ludmila Shopin1, Michael Cohen2, Shlomo Berliner2, Itzhak Shapira2, Natan M. Bornstein1 1
Department of Neurology; 2Department of Medicine 'D', Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Summary Increased fibrinogen concentration is a well known phenomenon following acute ischemic stroke. However, the natural course of this hyperfibrinogenemia is uncertain. We aimed to clarify whether it is of a transient or more persistent nature in patients who harbor an underlying morbid biology of atherothrombo-inflammation.Venous blood for fibrinogen measurements was obtained from the control group participants and from stroke patients within 24 hours of admission, as well as 12 months following the acute event. In order to perform a time course analysis, we divided our cohort into tiles of time from symptoms' onset and compared the fibrinogen concentrations usingANOVA.Elevated fibrinogen concentrations were found in stroke patients on admission compared with matched controls (p
