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Curriculum Vitae

Alvin, Chia-Feng Lu

Personal Data 盧家鋒 Alvin, Chia-Feng Lu, Ph.D. Address: 250 Wuxing Street, Taipei City, Taiwan 110 Tel: +886-2-27361661 ext. 3273/ +886-2-27372181 ext. 1133 Email: [email protected] Webpage: http://www.ym.edu.tw/~cflu Online Course: https://www.youtube.com/user/AlvinLu4016

Education National Yang-Ming University Taipei, Taiwan 2007-2012 Ph.D. Department of Biomedical Imaging and Radiological Sciences National Yang-Ming University Taipei, Taiwan 2002-2006 BSc Department of Medical Radiation Technology

Current Positions 08/2017－present, Assistant Professor, Department of Anatomy and Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan 09/2015－present, Chief Executive Officer, Translational Imaging Research Center, College of Medicine, Taipei Medical University, Taipei, Taiwan 08/2015－present, Adjunct Assistant Professor, Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taiwan 08/2015－present, Adjunct Assistant Professor, Department of Radiology, School of Medicine, Taipei Medical University, Taipei, Taiwan 08/2014－present, Adjunct Assistant Professor, Department of Physical Therapy and Assistive Technology, National Yang-Ming University, Taipei, Taiwan

Work Experience 09/2014－07/2017, Assistant Research Fellow, Translational Imaging Research Center, College of Medicine, Taipei Medical University, Taipei, Taiwan 08/2013－08/2014, Assistant Professor, Department of Physical Therapy and Assistive Technology, National Yang-Ming University, Taipei, Taiwan 01/2014－07/2014, Adjunct Assistant Research Fellow, Taipei City Hospital, Taipei, Taiwan 01/2013－07/2013, Postdoctoral Fellow, Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei

Certificates & Memberships 1. Assistant Professor Certificate, Ministry of Education, Reg. No: 038138, 2013, Taiwan. Last updated 8 / 10 / 2017

Curriculum Vitae

Alvin, Chia-Feng Lu

2. Certificate of Medical Radiation Technologist, Ministry of Health and Welfare, Reg. No: 005201, 2006, Taiwan. 3. Certificate of MRI IDEA Sequence Programming (MR8SDE), SIEMENS, Identification Number: CAD2W0A, Instructor: Mark A. Brown, August 2015. 4. Member of International Society for Magnetic Resonance in Medicine, USA, 2015-2017.

Personal Statement Chia-Feng Lu attained his Ph.D. at Department of Biomedical Imaging and Radiological Sciences in 2012 from the National Yang-Ming University under the mentorship of Professor Yu-Te Wu. His dissertation explored the organization of brain structural network for the patients with ponto-cerebellar atrophy from the perspective of local structure to global network efficiency using diffusion tensor images. He gave academic lectures of “MATLAB programming for medical signal analysis” and “Principles and applications of magnetic resonance imaging” for graduate students during past two semesters at National Yang-Ming University and released lesson videos and materials on the internet for free to facilitate students’ learning. A major focus recently is to develop an image platform in characterizing thalamocortical dysrhythmia, estimating cerebral hemodynamics, and quantifying venous drainage based on MRI, aiming to understanding the brain circulation for both arterial and venous systems in vivo under the effects of neurovascular diseases. The issue of patentability and the subsequent technique transfer for the developing techniques and platforms is of interest to him.

Research Supports Ministry of Science and Technology (MOST), Taiwan 2017-2019, NT$ 2,656,000 Neuroimage Biomarker of Thalamo-cortical Network for Outcome Prediction in Mild Traumatic Brain Injury: A Translational MRI Research PI: Chia-Feng Lu Role: PI Ministry of Science and Technology (MOST), Taiwan 2016-2017, NT$ 850,000 MR radiomics and radiogenomics for characterizing genotypes of breast cancer PI: Chia-Feng Lu Role: PI Ministry of Science and Technology (MOST), Taiwan 2015-2016, NT$ 753,000 Motion-Sensitive MR Imaging in Characterizing Brain Compliance in Cerebral Venous Hypertension: A Translational Study between Humans and Rats PI: Chia-Feng Lu Role: PI Last updated 8 / 10 / 2017

Curriculum Vitae

Taipei Medical University, Taiwan Research Grant for New Faculty PI: Chia-Feng Lu Role: PI

Alvin, Chia-Feng Lu

2015-2017, NT$ 600,000

Ministry of Science and Technology (MOST), Taiwan 2013-2014, NT$ 605,000 Training Benefit of Gait and Brain Activity Performance During Cognitive and Motor Dual tasks While Walking: A Near-Infrared Spectroscopy Study PI: Chia-Feng Lu Role: PI Taipei City Hospital, Taiwan 2013-2014, NT$ 800,000 Discrimination and prognosis of Alzheimer’s disease and mild cognitive impairment using EEG functional connectivity and structural MRI PI: Chia-Feng Lu Role: PI National Institute of Health, United States & Ministry of Science and Technology (MOST), Taiwan 2015-2018, NT$ 4,500,000 Characterization of Thalamocortical Dysrhythmia in Mild Traumatic Brain Injury using Simultaneous MRI and EEG Measurements and Preclinical N-acetylcysteine Treatment Response PI: Cheng-Yu Chen (Taipei Medical University) Role: Co-PI Ministry of Science and Technology (MOST), Taiwan

2016-2019, NT$ 3,073,000

MRI study on Trans-Neuronal Degeneration of the Thalamic Networks after Ischemic Stroke PI: Cheng-Yu Chen (Taipei Medical University) Role: Co-PI Ministry of Science and Technology (MOST), Taiwan 2016-2018, NT$2,400,000 Remodeling of Neuronal Network after Mild Traumatic Brain Injury: Small Animal MRI PI: Yu-Chieh Kao (Taipei Medical University) Role: Co-PI Ministry of Science and Technology (MOST), Taiwan 2017-2018, NT$1,200,000 In vivo Early Neuroimage Profiles of Injurious and Protective Responses in Neonatal Last updated 8 / 10 / 2017

Curriculum Vitae

Alvin, Chia-Feng Lu

Hypoxic-Ischemic Models Using 7T MRI (1/3) PI: Yu-Chieh Kao (Taipei Medical University) Role: Co-PI Ministry of Science and Technology (MOST), Taiwan 2015-2016, NT$ 800,000 Restoration of thalamocortical oscillation as a potential treatment for mTBI: a small animal MRI research PI: Yu-Chieh Kao (Taipei Medical University) Role: Co-PI Ministry of Science and Technology (MOST), Taiwan 2017-2020, NT$ 4,050,000 Dementia-Related Brain Abnormalities and Theta-Burst Stimulation in Major Depression with Prominent Cognitive Impairments. PI: Cheng-Ta Li (Taipei Veteran General Hospital) Role: Co-PI Ministry of Science and Technology (MOST), Taiwan 2014-2017, NT$ 4,050,000 Clinical biomarkers for diagnosing and predicting treatment outcome in major depressive disorders and generalized anxiety disorder: a study combing inhibitory neurocognition, paired-pulse transcranial magnetic stimulation, and near-infrared spectroscopy PI: Cheng-Ta Li (Taipei Veteran General Hospital) Role: Co-PI Ministry of Science and Technology (MOST), Taiwan 2014-2017, NT$ 2,678,000 Using diffusion modularity analysis to cluster the degenerative features from the EEG, structural MRI and DTI of SCA3 patients for establishing copula model among brain regions PI: Yu-Te Wu (National Yang-Ming University) Role: Co-PI Ministry of Science and Technology (MOST), Taiwan 2017-2020, NT$ 2,994,000 Dual task on gait performance and brain activity in pre-frail and mild cognitive impaired elderly PI: Ray-Yau Wang (National Yang-Ming University) Role: Co-PI Ministry of Science and Technology (MOST), Taiwan 2014-2017, NT$ 3,021,000 Effects of dual task on gait performance and brain activities-exploration of age and neurological diseases PI: Ray-Yau Wang (National Yang-Ming University) Last updated 8 / 10 / 2017

Curriculum Vitae

Alvin, Chia-Feng Lu

Role: Co-PI Ministry of Science and Technology (MOST), Taiwan Radiogenomic Mapping of Angiogenesis in Glioblastoma PI: Li-Chun Hsieh (Taipei Medical University Hospital) Role: Co-PI

2017-2018, NT$ 1,020,000

Ministry of Science and Technology (MOST), Taiwan Radiogenomic Mapping of Angiogenesis in Glioblastoma

2016-2017, NT$ 840,000

PI: Li-Chun Hsieh (Taipei Medical University Hospital) Role: Co-PI Ministry of Science and Technology (MOST), Taiwan 2017-2018, NT$ 1,198,000 The role of IL-15 system in immune response to cerebral ischemia-reperfusion and in the development of stroke immunotherapy PI: Gilbert Aaron Lee (Taipei Medical University Hospital) Role: Co-PI Ministry of Science and Technology (MOST), Taiwan 2016-2017, NT$ 851,000 Investigating the early MR biomarkers of the brain demyelination using myelin water imaging, diffusion kurtosis imaging, and chemical exchange saturation transfer (CEST) schemes: a translational study PI: Ping-Hua Tsai (Taipei Medical University) Role: Co-PI National Health Research Institutes (NHRI), Taiwan 2016-2019, NT$ 8,000,000 Development of Industry for Personalized Genomic Medicine, Subproject 3: Precision Medicine on Brain Tumor PI: Cheng-Yu Chen (Taipei Medical University) Role: Research Investigator Ministry of Health and Welfare (MOHW), Taiwan 2015-2017, NT$ 900,000 Taipei Medical University, Center of Excellence for Cancer Research (CECR): Imaging Core PI: Yun Yen (Taipei Medical University) Role: Research Investigator

Invited Talks 1. 06/2013: Clinical applications of brain circulation monitoring, Stroke and Neurovascular Center, Last updated 8 / 10 / 2017

Curriculum Vitae

Alvin, Chia-Feng Lu

Taipei Veterans General Hospital, Taipei, Taiwan. 2. 11/2013: Introduction of tissue classification techniques of DSC-MRI and fNIRS applications, Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan. 3. 07/2015, 08/2015: Principles of polygraph and signal processing in lie detection, National Security Bureau, Taipei, Taiwan. 5. 10/2015: Hands-on practice in resting-state fMRI analysis, Mind Research and Imaging Center, National Cheng Kung University, Tainan City, Taiwan. 6. 12/2015: Clinical applications of medical image and signal analyses, Taipei Medical University Hospital, Taipei, Taiwan. 7. 05/2016: Advanced image analysis in resting-state fMRI, Mind Research and Imaging Center, National Cheng Kung University, Tainan City, Taiwan. 8. 06/2016: What’s behind the Data? National Yang-Ming University, Taipei, Taiwan. 9. 07/2016: Introduction of translational imaging research, Taipei Medical University Hospital, Taipei, Taiwan. 10. 10/2016: Applications of functional near-infrared spectroscopy in neuroscience, National Tsing Hua University, Hsinchu, Taiwan. 11. 10/2016: Principles and applications of fNIRS in lie detection, National Security Bureau, Taipei, Taiwan. 12. 11/2016: Small-world mystery of human brain, Taipei Medical University Hospital, Taipei, Taiwan. 13. 12/2016: Advance in Translational Neuroimaging Research, National Yang-Ming University, Taipei, Taiwan. 14. 03/2017: Neuroimage X Humanities and Social Sciences Workshop, Research Institute for the Humanities and Social Sciences, Ministry of Science and Technology, Tainan City, Taiwan. 15. 03/2018: Translational Research in Mild Traumatic Brain Injury, XXI Symposium Neuroradiologicum (SNR 2018), Taipei, Taiwan.

International Journal Service 1. Reviewer, Computer Methods and Programs in Biomedicine (SCI). 2. Reviewer, Journal of Medical Imaging and Health Informatics (SCI). 3. Reviewer, Biomedical Engineering: Applications, Basis, and Communications (EI, SCI-E, SCI during 2012~2013). 4. Reviewer, Journal of Medical and Biological Engineering (SCI). 5. Reviewer, International Journal of Psychological and Brain Sciences.

Academic Service 1. Committee member of master degrees Last updated 8 / 10 / 2017

Curriculum Vitae

Alvin, Chia-Feng Lu

 Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, 2014, 2016, 2017.  Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, 2015.  Department of Physical Therapy and Assistive Technology, National Yang-Ming University, 2015.  Institute of Biophotonics, National Yang-Ming University, 2016.  Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, 2016, 2017.  Institute of Brain Science, National Yang-Ming University, 2017. 2. Committee member of Ph.D. degrees/candidate qualifying exams  Department of Physical Therapy and Assistive Technology, National Yang-Ming University, 2014, 2015, 2016, 2017.  Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, 2016, 2017.  Department of Electrical Engineering, National Taiwan University, 2017. 3. Ph.D. Dissertation Supervisory Committee  Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, 2017. 4. Reviewer of Research projects  Shu-Zen Junior College of Medicine and Management, 2016.

Peer-Reviewed Publications 1. Chia-Feng Lu, Bing-Wen Soong, Hsiu-Mei Wu, Shin Teng, Po-Shan Wang, Yu-Te Wu. Disrupted Cerebellar Connectivity Reduces Whole-Brain Network Efficiency in Multiple System Atrophy. Movement Disorders, 28(3):362-369, 2013. (SCI) 2. Chia-Feng Lu, Po-Shan Wang, Yuan-Lin Lao, Hsiu-Mei Wu, Bing-Wen Soong, Yu-Te Wu. Medullo-ponto-cerebellar White Matter Degeneration Altered Brain Network Organization and Cortical Morphology in Multiple System Atrophy. Brain Structure & Function, 219(3):947-958, 2014. (SCI) † Key Research Article on Psychology Progress 3. Chia-Feng Lu, Yan-Ci Liu, Yea-Ru Yang, Yu-Te Wu, Ray-Yau Wang. Maintaining Gait Performance by Cortical Activation During Dual-Task Interference: A Functional Near-Infrared Spectroscopy Study. PLoS ONE, 10(6): e0129390, 2015. (SCI) 4. Chia-Feng Lu, Wan-Yuo Guo, Feng-Chi Chang, Shang-Ran Huang, Yen-Chun Chou, Yu-Te Wu. Hemodynamic Segmentation of Brain Perfusion Images with Delay and Dispersion Effects Using an Expectation-Maximization Algorithm. PLoS ONE, 8(7): e68986, 2013. (SCI) 5. Shin Teng#, Chia-Feng Lu#, Po-Shan Wang, Cheng-Ta Li, Pei-Chi Tu, Chih-I Hung, Tung-Ping Last updated 8 / 10 / 2017

Curriculum Vitae

Alvin, Chia-Feng Lu

Su, Yu-Te Wu. Altered Resting-State Functional Connectivity of Striatal-Thalamic Circuit in Bipolar Disorder. PLoS ONE, 9(5): e96422, 2014. (SCI) #: equal contribution. 6. Chia-Feng Lu, Shin Teng, Chih-I Hung, Po-Jung Tseng, Liang-Ta Lin, Po-Lei Lee, Yu-Te Wu. Reorganization of Functional Connectivity during the Motor Task Using EEG Time-frequency Cross Mutual Information Analysis. Clinical Neurophysiology, 122:1569-1579, 2011. (SCI) 7. Cheng-Ta Li, Chia-Feng Lu, Hui-Ching Lin, Ying-Zu Huang, Chi-Hung Juan, Tung-Ping Su, Ya-Mei Bai, Mu-Hong Chen, Wei-Chen Lin, Cortical Inhibitory and Excitatory Function in Drug-Naive Generalized Anxiety Disorder. Brain Stimulation, 10(3):604-608, 2017. (SCI) 8. Duen-Pang Kuo, Chia-Feng Lu, Michelle Liou, Yung-Chieh Chen, Hsiao-Wen Chung, Cheng-Yu Chen, Differentiate Infarct Core from Ischemic Penumbra by Diffusion Tensor Imaging-Derived Metrics Within the First 4.5 Hours in a Rat Model. Korean Journal of Radiology, 18(2):269-278, 2017. (SCI, highlighted as Cover Story) 9. Yuan-Lin Liao, Chia-Feng Lu, Yung-Nien Sun, Chieh-Tsai Wu, Jiann-Der Lee, Shih-Tseng Lee, Yu-Te Wu. Three-Dimensional Reconstruction of Cranial Defect Using Active Contour Model and Image Registration. Medical & Biological Engineering & Computing, 49(2): 203-211, 2011. (SCI) 10. Yuan-Lin Liao, Chia-Feng Lu, Chieh-Tsai Wu, Jiann-Der Lee, Shih-Tseng Lee, Yung-Nien Sun, Yu-Te Wu. Using Three-Dimensional Multigrid-Based Snake and Multiresolution Image Registration for Reconstruction of Cranial Defect. Medical & Biological Engineering & Computing, 51,89-101, 2013. (SCI) 11. Yen-Chun Chou, Chia-Feng Lu, Wan-Yuo Guo and Yu-Te Wu. Blind Source Separation of Hemodynamics from Magnetic Resonance Perfusion Brain Images Using Independent Factor Analysis. "Mathematical Methods for Images and Surfaces" in International Journal of Biomedical Imaging, 2010, 360568. (EI) 12. Yuan-Lin Liao, Po-Shan Wang, Chia-Feng Lu, Chih-I Hung, Cheng-Ta Li, Ching-Po Lin, Jen-Chuen Hsieh, Tung-Ping Su, Yu-Te Wu. Cortical Shape and Curvedness Analysis of Structural Deficits in Remitting and Non-remitting Depression. PLoS ONE, 8(7):e68625, 2013. (SCI) 13. Wang, Po-Shan, Chien-Li Yeh, Chia-Feng Lu, Hsiu-Mei Wu, Bing-Wen Soong, and Yu-Te Wu. The involvement of supratentorial white matter in multiple system atrophy: a diffusion tensor imaging tractography study. Acta Neurologica Belgica 117(1):213-220,2017. (SCI) 14. Shin-Yi Chiou, Ray-Yau Wang, Kwong-Kum Liao, Yu-Te Wu, Chia-Feng Lu, Yea-Ru Yang. Co-activation of primary motor cortex ipsilateral to muscles contracting in a unilateral motor task. Clinical Neurophysiology, 124:1353-1363, 2013. (SCI) 15. Chia-Shu Lin, Yong Liu, Wei-Yuan Huang, Chia-Feng Lu, Shin Teng, Tzong-Ching Ju, Tianzi Jiang, Yong He, Yu-Te Wu, Jen-Chuen Hsieh. Sculpting the intrinsic modular organization of spontaneous brain activity by art. PLoS ONE, 8(6):e66761, 2013. (SCI) 16. Shin-Yi Chiou, Ray-Yau Wang, R. Edward Roberts, Yu-Te Wu, Chia-Feng Lu, Kwong-Kum Liao, Yea-Ru Yang. Fractional Anisotropy in Corpus Callosum is Associated with Facilitation of Motor Representation during Ipsilateral Hand Movements. PLoS ONE, 9(8):e104218, 2014. (SCI) Last updated 8 / 10 / 2017

Curriculum Vitae

Alvin, Chia-Feng Lu

17. Shun-Wen Chang, Shin Teng, Chia-Feng Lu. Effects of Score Transformation on the Composite Scores under the Multivariate Proficiency Distribution Using IRT. Psychological Testing, 60(3):457-488, 2013. (TSSCI) 18. Shun-Wen Chang, Shin Teng, Chia-Feng Lu. Explorations of Composite Scores under the Multivariate Proficiency Distribution Using IRT. Bulletin of Educational Psychology, 45(2):261-278, 2013. (TSSCI)

Paper in revision or under review 1. Shin Teng#, Chia-Feng Lu#, Tung-Ping Su, Po-Shan Wang, Pei-Chi Tu, Cheng-Ta Li, Yu-Te Wu. Hereditary Predisposition and Disease Expression of Bipolar Disorder Reflect on the Cortical Folding Structures. Psychiatric Research: Neuroimaging, major revision. (SCI) # equal contribution 2. Cheng-Ta Li, Chia-Feng Lu, Hui-Ching Lin, Yu-Te Wu, Chi-Hung Juan, Ruei-Wen Chu, Szu-Hui Lee, Yu-Wen Chang, Tung-Ping Su, Attenuated Cortical Responsiveness to Motor and Cognitive Tasks as a Characteristic Feature of Pathological Anxiety. Psychological Medicine, under review. (SCI) 3. Cheng-Ta Li, Ying-Zu Hunag, Chia-Feng Lu, Hui-Ching Lin, Tung-Ping Su, Ya-Mei Bai, Mu-Hong Chen, Wei-Chen Lin, Evidence for Cortical Excitatory Impairment as a Core Feature of Generalized Anxiety Disorder, submitted to Brain. (SCI)

Peer-Reviewed Congress Publications 1. Chia-Feng Lu, Yen-Chun Chou, Wan-Yuo Guo, Yu-Te Wu. Brain MR Perfusion Image Segmentation Using Independent Component Analysis and Hierarchical Clustering. The 29th Annual International Conference of the IEEE, EMBS 2007, Lyon, Aug 22-26, 2007. 2. Chia-Feng Lu, Po-Shan Wang, Yen-Chun Chou, Hsiao-Chien Li, Bing-Wen Soong, Yu-Te Wu. Segmentation of diffusion-weighted brain images using expectation maximization algorithm initialized by hierarchical clustering. The 30th Annual International Conference of the IEEE, EMBS 2008, Vancouver, Aug 25-28, 2008. 3. Yu-Te Wu, Yen-Chun Chou, Chia-Feng Lu, Shang-Ran Huang, Wan-Yuo Guo. Tissue Classification from Brain Perfusion MR Images Using Expectation-Maximization Algorithm Initialized by Hierarchical Clustering on Whitened Data. In Proceeding of The 13th International Conference on Biomedical Engineering, Singapore, December 3-6, 2008. 4. Chia-Feng Lu, Po-Shan Wang, Yen-Chun Chou, Hsiao-Chien Li, Bing-Wen Soong, Yu-Te Wu. Multi-tissue Classification of Diffusion-Weighted Brain Images in Multiple System Atrophy Using Expectation Maximization Algorithm Initialized by Hierarchical Clustering. In Proceeding of The 13th International Conference on Biomedical Engineering, Singapore, December 3-6, 2008.

Last updated 8 / 10 / 2017

Curriculum Vitae

Alvin, Chia-Feng Lu

5. Chia-Feng Lu, Po-Shan Wang, Bing-Wen Soong, Yen-Chun Chou, Hsiao-Chien Li, Yu-Te Wu. Multi-tissue Classification of Diffusion-Weighted Brain Images in Multiple System Atrophy. 2008 International Symposium on Biomedical Engineering, Taoyuan, Taiwan, December 12-13, 2008. 6. Shang-Ran Huang, Chia-Feng Lu, Yen-Chun Chou, Feng-Chi Chang, Wan-Yuo Guo, Yu-Te Wu. Hemodynmaics Segregation Using Expectation-Maximization Algorithm Initialized by Hierarchical Clustering on MR Dynmaic Images from Patients with Unilateral Internal Carotid Artery Stenosis. World Congress, Munich, Germany, 2009. 7. Lu CF, Hung CY, Tseng PJ, Lin LT, Wang ZY, Wu YT. Recognition of Arm-Movement Electroencephalography (EEG) Using Motor-Related Intrinsic Mode Functions Filtering and Cross Mutual Information. World Congress, Munich, Germany, 2009. 8. Yuan-Lin Liao, Chia-Feng Lu, Shang-Ran Huang, Shih-Tseng Lee, Jiann-Der Lee, Yung-Nien Sun, Yu-Te Wu. Skull-based registration of pre-operative CT images with intra-operative CT images for the application on partial skull reconstruction. The 5th Asian Conference on Computer Aided Surgery, Chang Bin, Taiwan, July 3-4, 2009. 9. Lu CF, Hung CY, Tseng PJ, Lin LT, Wang ZY, Wu YT. Recognition of Resting and Movement-Related Electroencephalography (EEG) Using Time-Frequency Cross Mutual Information. In Proceedings of CACS International Automatic Control Conference, Taipei, Taiwan, November 27-29, 2009. 10. Lu, C. F., Teng, S., Wang, P. S., Yeh, T. C., Su, T. P., Hsieh, J. C. and Wu, Y. T. (2010) Investigation of Differences on Cortical Connectivity Between Patients With Major Depressive Disorder and Normal Subjects Using MR Diffusion Tensor Imaging. The 2nd International Conference on Bioinformatics and Biomedical Technology, ChengDu, China. 11. Lu, C. F., Teng, S., Wang, P. S., Yeh, T. C., Su, T. P., Hsieh, J. C. and Wu, Y. T. (2010) A Neuronal Fiber Tracking Study for Major Depressive Disorder Using MR Diffusion Tensor Imaging With Fiber Tractography. The 2nd International Conference on Bioinformatics and Biomedical Technology, ChengDu, China. 12. Teng, S., Lu, C. F., Wang, P. S., Yeh, T. Z., Su, T. P., Hsieh, J. C., and Wu, Y. T. (2010) Investigation of Differences on Functional Connectivity in Major Depressive Disorder Using Functional Magnetic Resonance Imaging. The 2nd International Conference On Bioinformatics and Biomedical Technology, Chengdu, China. 13. Yuan-Lin Liao, Yung-Nien Sun, Chia-Feng Lu, Chieh-Tsai Wu, Shih-Tseng Lee, Jiann-Der Lee, and Yu-Te Wu. (2010)Skull-Based Registration of Intra-subject Brain CT Images: The Effects of Different Resolutions and Partial Contents. The 2nd International Conference On Bioinformatics and Biomedical Technology, Chengdu, China. 14. Peii Chen, Chih-I Hung, Chia-Feng Lu, Anna M. Barrett, Glenn Wylie, and Yu-Te Wu. Sex Differences in Functional Connectivity at Rest. The 63rd Annual Meeting of the American Academy of Neurology. Honolulu, April 9 - 16, 2011. Last updated 8 / 10 / 2017

Curriculum Vitae

Alvin, Chia-Feng Lu

15. Shun-Wen Chang, Shin Teng, Chia-Feng Lu. Effects of Score Transformation on the Composite Scores under the Multivariate Proficiency Distribution Using IRT. 2011 NCME Annual Meeting, April 7 - 11, New Orleans, Louisiana. 16. Shun-Wen Chang, Shin Teng, Chia-Feng Lu. Effects of Weighting Schemes on the Composite Scores under the Multivariate Proficiency Distribution Using IRT. 2012 AERA Annual Meeting, April 13 – 17, Vancouver, Canada. 17. Chia-Feng Lu, Shin Teng, Hsiu-Mei Wu, Wei-Yuan Huang, Jen-Chuen Hsieh, Yu-Te Wu. Structural Connectivity for Human Bilateral Insulae Using Diffusion Tensor Imaging. The 18th Annual Meeting of the Organization for Human Brain Mapping, Beijing, China, June 10-14, 2012. 18. Shin Teng, Chia-Feng Lu, Wei-Yuan Huang, Jen-Chuen Hsieh, Yu-Te Wu. The modular organization of aesthetic experience in painters using resting-state fMRI. The 18th Annual Meeting of the Organization for Human Brain Mapping, Beijing, China, June 10-14, 2012. 19. Feng, WC, Huang, SR, Hung, CI, Lu, CF, Wang, PS, Wu, YT. Using Functional Magnetic Resonance Imaging for the Analysis of Functional Connectivity when Watching Movie Trailers. Annual Symposium on Biomedical Engineering and Technology, Taoyuan, Taiwan, November 17-18, 2012. 20. Chia-Feng Lu, Shin Teng, and Yu-Te Wu. Dynamics of Hemoglobin States in the Sensorimotor Cortex During Motor Tasks: A Functional Near Infrared Spectroscopy Study. The 35th Annual International Conference of the IEEE, EMBS 2013, Osaka, Japan, July 3-7, 2013. 21. Shin Teng, Chia-Feng Lu, Po-Shan Wang, Chih-I Hung, Cheng-Ta Li, Pei-Chi Tu, Tung-Ping Su, Yu-Te Wu. Classification of Bipolar Disorder using Basal-ganglia-related Functional Connectivity in the resting state. The 35th Annual International Conference of the IEEE, EMBS 2013, Osaka, Japan, July 3-7, 2013. 22. Yan-Ci Liu, Chia-Feng Lu, Yea-Ru Yang, Yu-Te Wu, Ray-Yau Wang. Gait Performance and Brain Activity during Dual Task Walking: A Functional Near-Infrared Spectroscopy Study. Physiology, London, 30 June - 2 July, 2014. 23. Po-Shan Wang, Shang-Ran Huang, Chao-Wen Tsai, Chia-Feng Lu, Shin Teng, C-I Hung, Yu-Te Wu. Attention Drawing of Movie Trailers Revealed by Electroencephography Using Sample Entropy. The 2nd International Conference of Biomedical Engineering (ICBE), Beiji, China, June 13-15, 2014. 24. Chia-Feng Lu, Yuh-Jen Wang, Shin Teng, Yu-Te Wu, Sui-Hing Yan. Altered Network Organization in Mild Alzheimer's Disease Compared to Mild Cognitive Impairment Using Resting-State EEG. International Conference on Biomedical Engineering, Kyoto, Japan, Nov 13-14, 2014. 25. Chia-Feng Lu, Yuh-Jen Wang, Yu-Te Wu, Sui-Hing Yan. Relations of Progression in Cognitive Decline with Initial EEG Resting-State Functional Network in Mild Cognitive Impairment. International Conference on Biomedical Engineering, Kyoto, Japan, Nov 13-14, 2014. Last updated 8 / 10 / 2017

Curriculum Vitae

Alvin, Chia-Feng Lu

26. Chia-Feng Lu, Hua-Shan Liu, Ping-Huei Tsai, Fei-Ting Hsu, Pen-Yuan Liao, Li-Chun Hsieh, Cheng-Yu Chen. Resting-State fMRI Connectivity for Detecting Thalamo-Cortical Dysrhythmia (TCD) and locating the Cortical Lesion Sites. The 64th Annual Meeting of RSROC, Taipei, Taiwan, March 21-22, 2015. 27. Cheng-Yu Chen, Duen-Pang Kuo, Hsiao-Wen Chung, Michelle Liou, Chia-Feng Lu. Diffusion Tensor Imaging Study of Ischemic Stroke: A Rat Model of Permanent Middle Cerebral Artery Occlusion with Normobaric Hyperoxygenation. The 64th Annual Meeting of RSROC, Taipei, Taiwan, March 21-22, 2015. 28. Fei-Ting Hsu, Li-Chun Hsieh, Ping-Huei Tsai, Hua-Shan Liu, Chia-Feng Lu, Cheng-Yu Chen. Radiogenomic Imaging-linking Advanced MRI and Molecular Diagnostic. The 64th Annual Meeting of RSROC, Taipei, Taiwan, March 21-22, 2015. 29. Chia-Feng Lu, Fei-Ting Hsu, Li-Chun Hsieh, Yu-Chieh Jill Kao, Hua-Shan Liu, Ping-Huei Tsai, Pen-Yuan Liao, Cheng-Yu Chen. Imaging Angiogenesis Genotype of Glioblastoma by Radiomic Features of Multimodality MRI. The 24th Annual Meeting & Exhibition of ISMRM, Singapore, May 7-13, 2016. 30. Yu-Chieh Jill Kao, Chia-Feng Lu, Hua-Shan Liu, Fei-Ting Hsu, Ping-Huei Tsai, Li-Chun Hsieh, Pen-Yuan Liao, Cheng-Yu Chen. Gd-enhanced Susceptibility Weighted Imaging in Neonatal Rats. The 24th Annual Meeting & Exhibition of ISMRM, Singapore, May 7-13, 2016. 31. Kevin Li-Chun Hsieh, Fei-Ting Hsu, Chia-Feng Lu, Cheng-Yu Chen. Radiogenomic Mapping of Dysregulated Angiogenesis in Glioblastoma. The 24th Annual Meeting & Exhibition of ISMRM, Singapore, May 7-13, 2016. 32. Cheng-Yu Chen, Fei-Ting Hsu, Hua-Shan Liu, Ping-Huei Tsai, Chia-Feng Lu, Yu-Chieh Kao, Li-Chun Hsieh, Pen-Yuan Liao. Low Apparent Diffusion Coefficient Values Correlate with Enhancing Mitosis and Cell Proliferation Expression in glioblastoma using Locus-Specific Radiogenomic Map. The 24th Annual Meeting & Exhibition of ISMRM, Singapore, May 7-13, 2016. 33. Ping-Huei Tsai, Hua-Shan Liu, Fei-Ting Hsu, Yu-Chieh Kao, Chia-Feng Lu, Li-Chun Hsieh, Pen-Yuan Liao, Hsiao-Wen Chung, Cheng-Yu Chen. Improvement of in vivo glucoCEST imaging in rat brain using inverse z-spectrum analytical scheme at 7.0 T. The 24th Annual Meeting & Exhibition of ISMRM, Singapore, May 7-13, 2016. 34. Chia-Feng Lu, Hsin-Yi Lai, Fei-Ting Hsu, Yu-Chieh Kao, Hua-Shan Liu, Ping-Huei Tsai, Li-Chun Hsieh, Pen-Yuan Liao, Cheng-Yu Chen. MR radiomics for characterizing molecular subtypes of breast cancer. The 65th Annual Meeting of RSROC, Kaohsiung city, Taiwan, March 19-20, 2016. 35. Yu-Chieh Kao, Chia-Feng Lu, Ping-Huei Tsai, Hua-Shan Liu, Fei-Ting Hsu, Li-Chun Hsieh, Pen-Yuan Liao, Cheng-Yu Chen. 2016. Remodeling of Neuronal Network after Mild Traumatic Brain Injury Small Animal MRI Study. The 65th Annual Meeting of RSROC, Kaohsiung city, Taiwan, March 19-20, 2016. Last updated 8 / 10 / 2017

Curriculum Vitae

Alvin, Chia-Feng Lu

36. Chia-Yu Huang, Chang-Ming Chern, Chia-Feng Lu, Jong-Ling Fuh, Feng-Chi Chang. Monitoring the Therapeutic Effect of Internal Carotid Artery Stenting: A Pilot Study of Functional NIRS. The 22nd Annual Meeting of the Organization for Human Brain Mapping, Geneva, Switzerland, June 26-30, 2016. 37. Chia-Feng Lu, Li-Chun Hsieh, Yu-Chieh Jill Kao, Ho-Fang Huang, Wen-Jin Hsieh, Fei-Ting Hsu, Ping-Huei Tsai, Hua-Shan Liu, Hui-Hsien Lin, Huai-Lu Chen, and Cheng-Yu Chen. Symptom-related Alterations of Thalamocortical Connectivity in mild Traumatic Brain Injury: An fMRI Connectome Study. The 25th Annual Meeting & Exhibition of ISMRM, Hawaii, USA, April 22-24, 2017. 38. Chia-Feng Lu, Yu-Chieh Jill Kao, Huai-Lu Chen, Fei-Ting Hsu, Ping-Huei Tsai, Hua-Shan Liu, Li-Chun Hsieh, Gilbert Aaron Lee, and Cheng-Yu Chen. Reorganization of Rodent Resting-state Functional Networks after mild Traumatic Brain Injury. The 25th Annual Meeting & Exhibition of ISMRM, Hawaii, USA, April 22-24, 2017. 39. Chia-Feng Lu, Wen-Jin Hsieh, Yu-Chieh Jill Kao, Paul Blakeley, Fei-Ting Hsu, Hua-Shan Liu, Ping-Huei Tsai, Li-Chun Hsieh, and Cheng-Yu Chen. Global Change of Intrinsic Functional Networks as an Imaging biomarker of Alzheimer’s disease. The 25th Annual Meeting & Exhibition of ISMRM, Hawaii, USA, April 22-24, 2017. 40. Cheng-Yu Chen, Chia-Feng Lu, Li-Chun Hsieh, Yu-Chieh Jill Kao, Ping-Huei Tsai, Ho-Fang Huang. Disruption of Thalamo-cortical Tracts is Associated with Post-Concussion Symptoms in mild Traumatic Brain Injury Revealed by Automatic Tract-Based Analysis. The 55th Annual Meeting of ASNR, Long Beach, California, USA, April 22-27, 2017. 41. Paul Blakeley, Chia-Feng Lu, Fei-Ting Hsu, Li-Chun Hsieh, Yu-Chieh Jill Kao, Huai-Lu Chen, Ping-Huei Tsai, Hua-Shan Liu, Gilbert Aaron Lee, and Cheng-Yu Chen. Exploiting radiogenomics data for personalised prediction of glioblastoma. The 25th Annual Meeting & Exhibition of ISMRM, Hawaii, USA, April 22-24, 2017. 42. Yu-Chieh Jill Kao, Chia-Feng Lu, Huai-Lu Chen, Ping-Huei Tsai, Fei-Ting Hsu, Hua-Shan Liu, Gilbert Aaron Lee, Paul Blakeley, Li-Chun Hsieh, Bao-Yu Hsieh, and Cheng-Yu Chen. Evolving Functional Connectivity in Rats following Mild Traumatic Brain Injury. The 25th Annual Meeting & Exhibition of ISMRM, Hawaii, USA, April 22-24, 2017. 43. Yu-Chieh Jill Kao, Chia-Feng Lu, Huai-Lu Chen, Ping-Huei Tsai, Fei-Ting Hsu, Hua-Shan Liu, Gilbert Aaron Lee, Paul Blakeley, Li-Chun Hsieh, Bao-Yu Hsieh, and Cheng-Yu Chen. Behavioral and Image Evidence for Mild Traumatic Brain Injury in Rats with the Skull Helmet. The 25th Annual Meeting & Exhibition of ISMRM, Hawaii, USA, April 22-24, 2017. 44. Yu-Chieh Jill Kao, Chia-Feng Lu, Huai-Lu Chen, Ping-Huei Tsai, Cheng-Yu Chen. Evolution of Diffusion Tensor Signal after Impact Acceleration Injury in Experimental Mild Traumatic Brain Injury. The 66th Annual Meeting of RSROC, Taipei, Taiwan, March 18-19, 2017. 45. Kevin Li-Chun Hsieh, Cheng-Yu Chen, Chia-Feng Lu, Paul Blakeley. The Radiogenomic Portrait of the Unsuccess of Bevacizumab in Glioblastoma. The 55th Annual Meeting of ASNR, Last updated 8 / 10 / 2017

Curriculum Vitae

Alvin, Chia-Feng Lu

Long Beach, California, USA, April 22-27, 2017. 46. Hui-Hsien Lin, Hua-Shan Liu, Ping-Huei Tsai, Fei-Ting Hsu, Chia-Feng Lu, Yu-Chieh Jill Kao, Wen-Jin Hsieh, Ho-Fang Huang, Huai-Lu Chen, Paul Blakeley, Gilbert Aaron Lee, and Cheng-Yu Chen. Quantitative Susceptibility Mapping in Mild Traumatic Brain Injury. The 25th Annual Meeting & Exhibition of ISMRM, Hawaii, USA, April 22-24, 2017. 47. Ping-Huei Tsai, Fei-Ting Hsu, Hua-Shan Liu, Hsiao-Wen Chung, Yu-Chieh Kao, Chia-Feng Lu, Huai-Lu Chen, Paul Blakeley, Gilbert Aaron Lee, and Cheng-Yu Chen. 2-Deoxyglucose-Weighted MR Imaging in Rodent Brain Using Inverse Z-Spectrum Analytic Scheme. The 25th Annual Meeting & Exhibition of ISMRM, Hawaii, USA, April 22-24, 2017. 48. Ping-Huei Tsai, Yung-Chieh Chen, Shih-Wei Chiang, Hua-Shan Liu, Ming-Chung Chou, Fei-Ting Hsu, Yu-Chieh Kao, Chia-Feng Lu, Hsiao-Wen Chung, and Cheng-Yu Chen. Increased Anisotropy as Possible Compensatory Plasticity of Ventral Thalamic Nuclei to Gait Disturbance in Patients with Idiopathic Normal Pressure Hydrocephalus. The 25th Annual Meeting & Exhibition of ISMRM, Hawaii, USA, April 22-24, 2017. 49. Chia-Feng Lu, Fei-Ting Hsu, Li-Chun Hsieh, Yu-Chieh Jill Kao, Cheng-Yu Chen. Machine Learning based Classification of Glioma Subtypes Characterized by MR Radiomics. The 103rd Annual Meeting of Radiological Society of North America (RSNA 2017), Scientific Posters, Chicago, USA, Nov 26-Dec 1, 2017. 50. Cheng-Yu Chen, Chia-Feng Lu, Fei-Ting Hsu, Paul Blakeley, Li-Chun Hsieh, Yu-Chieh Jill Kao, Ping-Huei Tsai, Yung-Hsiao Chiang, Wan-Yuo Guo, Ming-Hsong Chen, Chih-Chun Wu, Liang-Wei Chen, Hung Wen Kao, Yuan-Hao Chen, Hsin-I Ma. Personalized Survival Prediction Using Random Forest Survival Model on MR Radiomic Features in Gliomas. The 103rd Annual Meeting of Radiological Society of North America (RSNA 2017), Scientific Papers (Oral), Chicago, USA, Nov 26-Dec 1, 2017.

Patents Lee, Shih-Tseng；Wu, Yu-Te；Liao, Yuan-Lin；Lu, Chia-Feng；Lee, Jiann-Der Method for Manufacturing Artificial Implants US Patent No.: US008200355B2 US Patent Date: June 2012 TW Patent Number: I381828 TW Patent Date: Jan 2013 Chen, Cheng-Yu ; Kuo, Duen-Pang ; Chung, Hsiao-Wen ; Lu, Chia-Feng ; Kao, Yu-Chieh An Image Analysis Method for Assessing Infarct Core, Ischemic Penumbra, and Stroke Onset Using MR diffusion tensor imaging US and TW Patent under review, 2017.


Curriculum Vitae

Alvin, Chia-Feng Lu

Graduate and Undergraduate Courses 1. Principles and applications of magnetic resonance imaging (Undergraduate) 2. Magnetic resonance imaging in medicine (Undergraduate) 3. Medical imaging processing and analysis (Intern, Resident) 4. MATLAB programming for medical signal analysis (Graduate) 5. MATLAB graphic user interface for biomedical signal analysis (Graduate) 6. The principles and applications of functional near-infrared spectroscopy (Graduate) 7. Practice in resting-state fMRI analysis (Graduate) 8. Computer Architecture for Dentists (Undergraduate) Course outlines & materials: http://www.ym.edu.tw/~cflu/CFLu_course.html Online videos (Chinese): https://www.youtube.com/user/AlvinLu4016


Curriculum Vitae

Alvin, Chia-Feng Lu

Platform Development < Medical Image (DICOM) Processing Platform, MIPP 2015-2016 >

 DICOM read and sort for MRI and CT images, optimized for brain, breast, and liver imaging.  Cross-modality image co-registration and interpolation.  Multi-modality operation of region of interest (ROI) and thresholding.  Computation of 497 Radiomic features, including intensity-based, geometry-based, textural analyses, and wavelet decomposition for each MR modality (CET1, T2W, T2 FLAIR, ADC, Cp/rCBV, Ktrans/K2 maps), up to 2942 Radiomic features.  Correlation and multivariate linear regression analyses between image features and gene expression of tumors.  Series images crop, zoom, window/contrast adjustment, and print.  Output processed results as Excel sheets.


Curriculum Vitae

Alvin, Chia-Feng Lu

< Animal MRI processing platform, AMPP 2015-2016 >

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Support image import of Brucker 2dseq, sdt/spr file, and Nifti formats. Design of “file tree” organization for longitudinal dataset processing.

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Analyses of dynamic susceptibility contrast (DSC) imaging, diffusion tensor imaging (DTI), susceptibility-weighted imaging (SWI), and functional MRI. Brain extraction and ROI operation. Atlas-based brain tissue classification and brain region identification. Tissue-based analysis and value extraction/export. Series images crop, zoom, window/contrast adjustment, and print. Export as mat-file, Nifti formats and direct output to Matlab workspace.

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Curriculum Vitae

Alvin, Chia-Feng Lu

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Batch functional connectivity analyses on human brain or animal BOLD fMRI data. Preprocessing functions comprise skull stripping, bandpass filtering, head motion regression, whole-brain signal regression, WM/CSF regression, and principal component analysis (PCA) for noise reduction. Estimations of functional connectivity based on the group/subject independent component anlysis (ICA), total correlation analysis, partial correlation analysis, and spectrum analysis. Three modes for connectivity construction, including the construction of connectivity map (1 ROI to all voxels), connectivity matrix (ROIs to ROIs), and component map (voxels within specific ROIs to other ROIs), are built in.


Curriculum Vitae

Alvin, Chia-Feng Lu

< Perfusion Analysis Platform, PAP 2014>

 Automatic tissue Classification based on signal time curve using hierarchical clustering initialized expectation-maximization (HC-EM) algorithm.  Quantification features for user-defined ROI or tissue-based region analysis.  File Input/Output, logfile tracking, and report generator.


Curriculum Vitae

Alvin, Chia-Feng Lu

< Tractography-Based Connectivity Analysis Platform, TBCAP 2013>

 Visualization of whole-brain structural connectivity (based on DTI tractrography), region-based connectivity, and user-defined network connectivity.  Connectivity-based parcellation of brain region and subregion classification.  3D representative fiber tract for group analysis.  Hierarchical analysis of region-specific network, interpreting the concept of secondary pathways.  Small-world analysis (computation of topological properties bases on graph theory).


Curriculum Vitae

Alvin, Chia-Feng Lu

 Visualization of VICON motion tracking system, multiple data integration and analyses.  Interactive interface for assessing gait traits and determining gait cycles.  Quantitative analyses of knee joint stability characterized by joint-plane translations, angular changes, velocity, and accelerations.  Analytic data export in Excel format for the subsequent statistics.

Chia-Feng Lu Supervisor of Laboratory of NeuroImage Biomarker Analysis (NBA), Translational Imaging Research Center, Taipei Medical University.
