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Neonatales Abstinenzsyndrom bei europäischen und nordamerikani schen Neugeborenen: Unterschiede im klinischen Verlauf an Hand von Daten einer prospektiven randomisierten Studie DOI 10.1055/s-0034-1372586 Klin Padiatr For personal use only. No commercial use, no depositing in repositories.
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Original Article
Neonatales Abstinenzsyndrom bei europäischen und nordamerikanischen Neugeborenen: Unterschiede im klinischen Verlauf an Hand von Daten einer prospektiven randomisierten Studie Neonatal Abstinence Syndrome in European and North American Neonates: Differences in Clinical Characteristics Derived from a Prospective Randomized Trial
Authors
L. Kirchner1, K. Graf-Rohrmeister1, K. Klebermass-Schrehof1, M. Weninger1, R. Jagsch2, V. Metz3, A. Unger3, G. Fischer3
Affiliations
1
Division of General Paediatrics and Neonatology, Department of Paediatrics and Adolescent Medicine, Medical University of Vienna, Austria 2 Faculty of Psychology, University of Vienna, Austria 3 Addiction Clinic, Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria
Keywords ▶ intrauterine opioid exposure ● ▶ neonatal abstinence ● syndrome ▶ methadone ● ▶ buprenorphine ● ▶ morphine ●
Abstract
Zusammenfassung
Background: Due to the steady increase of substance-dependent pregnant women the neonatal abstinence syndrome has become an increasingly important issue in neonatology. The present study investigates site-specific differences of detailed symptoms and treatment of neonatal abstinence syndrome within the context of an international multicenter clinical trial. Methods: Site specific neonatal data analyses from a prospective randomized, double-blind, double-dummy clinical trial (MOTHER study) was performed. A standardized NAS rating and treatment protocol was applied, while nonpharmacological care of NAS symptoms differed across the sites. Results: Urban US neonates exhibited most neurological symptoms (p
