PHRM 1430 - University of Manitoba

Applied Pathophysiology PHRM 1430 2017 Credit Hours: 3 Class contact hours: 3 hours/week in 2nd Term: Mondays and Wednesdays 9:00 -10:30am Lecture Location: 2nd Floor Lecture Theatre Apotex Centre

Course Coordinator: Dr. Mike Namaka (Room 319 Apotex Ctr, 474-8380, e-mail: [email protected] Subject material will be introduced by different faculty members who are specialists in the field. Their names, subject area, and phone numbers are listed below: Instructor Dr. M. Namaka Rick Thurmeier Dr. Lori Wazny Dr. H. Iacovides Dr. D. Turcotte

Phone number 474-8380 [email protected] 237-2630 [email protected] 787-2703 [email protected] 474-8407 [email protected] 272-3170 [email protected]

Purpose of the Course: To understand the pathophysiological processes that contributes to human disease for selected organ systems. Course content will prepare pharmacy students for subsequent courses related to diagnosis and management of disease associated with pathophysiologic dysfunction / alterations.

Learning Outcomes: By the end of the course, students should be able to demonstrate the following: Learning outcome Bloom’s Taxonomy Level of Learning Define medical terminology as it applies to human disease Ideas – Knowledge states Describe selected diagnostic procedures used to diagnose a Ideas – Comprehension disease Summarize the etiology of a selected disease state Ideas – Comprehension Use a diagram or picture to explain a pathophysiological Connections - Application disease process Relate patient signs and symptoms to a pathophysiological disease process Connections – Analysis Propose mechanisms of medications that would be beneficial in selected disease states.

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Extensions – Synthesis

Background and Prerequisites Required: The pathophysiology course is designed such that students will have completed the necessary physiology lectures prior to coming to the pathophysiology class. If students have not yet covered a topic in their Human Physiology class, please ask them to review the information in the textbook entitled: “Human physiology: from cells to systems / Lauralee Sherwood, Robert Kell. 1st Canadian Edition. 2010. NJM Health Sciences Library RESERVE QT 104 S554ha 2010” or via the EBook entitled: Ganong’s Review of Medical Physiology. Kim E. Barrett, Susan M. Barman, Scott Boitano, Heddwen Brooks. 23rd Edition Online: Access Pharmacy http://proxycheck.lib.umanitoba.ca/libraries/online/proxy.php?http://www.accesspharmacy.com/r esourceToc.aspx?resourceID=11 It will be assumed that students have read the appropriate material in their physiology and pathophysiology texts prior to coming to class.

Assessment and Grading: Summative Assessment Exam Mid-Term Examination Final Examination (non-cumulative)

% of Final Grade 40% 60 %

Date TBA TBA (Scheduled by the University during exam week)

Exam Format: Midterm and Final examinations will be 2 hours in duration. Both the midterm and final exam will be multiple choice and/or short answer questions. Short answer questions may include diagram labelling, drawing a diagram to explain a disease process, listing facts, explanation of a pathophysiologic mechanism or interpretation a patient case to identify signs and symptoms related to a disease state. All questions covered in the examinations will be based on all material discussed in class plus the assigned reading material. Students will be assigned a letter grade for the course based on the following table listed below: Letter % Achieved Grade Point Description Grade 90 – 100

A+

4.5

Exceptional

80 – 89

A

4.0

Excellent

75 – 79

B+

3.5

Very good

70 – 74

B

3.0

Good

65 – 69

C+

2.5

Satisfactory

60 – 64

C

2.0

Adequate

50 – 59

D

1.0

Marginal

0 – 49

F

0

Failure

Assessment Policy: Students who cannot complete any aspects of the course for medical reasons must contact the course coordinator (Dr. Michael Namaka) at the earliest possible time. Please consult the 2

University of Manitoba’s Undergraduate Calendar and the Faculty of Pharmacy Student Handbook for specific regulations regarding academic dishonesty, attendance, examinations and scholastic progress. All students are expected to attend classes unless previously excused by the course coordinator. Class attendance is a mandatory requirement of the course. Academic Difficulties It is strongly recommended that if students are experiencing difficulty understanding the various topics covered throughout the course that they request help and feedback with the appropriate instructor by scheduling a mutually agreeable appointment. The contact information for all expert facilitators can be found on the first page of this syllabus. Student Accessibility Services (SAS) provides support and advocacy for students with disabilities and can provide students with academic accommodations. Students have to register with SAS to be eligible for academic accommodations. For more information, the SAS website can be accessed here: http://umanitoba.ca/student/saa/accessibility/index.html.

Course Textbooks and Reference Material: PATHOPHYSIOLOGY TEXTS Note: Access to e-books online requires authentication with library ID & password. Required Reading Texts: E-Books The majority of pre-class readings will be drawn from the following two textbooks: (Available from the Pharmacy Toolkit: http://libguides.lib.umanitoba.ca/pharmacy ) 1. Pathophysiology of disease: an introduction to clinical medicine / edited by Stephen J. McPhee, Gary D. Hammer. 6th Edition. Online: Access Pharmacy http://proxycheck.lib.umanitoba.ca/libraries/online/proxy.php?http://www.accesspharmac y.com/resourceToc.aspx?resourceID=17 2. Pharmacotherapy: a pathophysiologic approach / Joseph T. DiPiro, et al. 8th Edition. Online: AccessPharmacy http://proxycheck.lib.umanitoba.ca/libraries/online/proxy.php?http://www.accesspharmac y.com/resourceToc.aspx?resourceID=669 Recommended Texts: Robbins and Cotran pathologic basis of disease / V. Kumar, et al. Professional ed. Online: MD Consult http://proxycheck.lib.umanitoba.ca/libraries/online/proxy.php?http://home.mdconsult.com/das/bo ok/view/1249 Note: Print Textbooks on 2-hour reserve at the Neil John Maclean Health Sciences Library 1. Pathophysiology : the biologic basis for disease in adults and children / [edited by] Kathryn L. McCance, Sue E. Huether. 6th ed. 2010. NJM Health Sciences Library RESERVE QZ 4 P3027p6 2010 3

2. Essentials of pathophysiology : concepts of altered health states / Carol Mattson Porth. 3rd ed. Philadelphia: Lippincott Williams & Wilkins, 2011. NJM Health Sciences Library RESERVE QZ 4 P851e3 2011 3. Understanding pathophysiology / Sue E. Huether, Kathryn L. McCance. 4th ed. St. Louis, Mo: Mosby, 2008. NJM Health Sciences Library RESERVE QZ 4 H8903u4 2008 Suggested References for Physiology background (if required): 1. Ganong’s Review of Medical Physiology. Kim E. Barrett, Susan M. Barman, Scott Boitano, Heddwen Brooks. 23rd Edition Online: AccessPharmacy http://proxycheck.lib.umanitoba.ca/libraries/online/proxy.php?http://www.accesspharmacy.com/r esourceToc.aspx?resourceID=11 2. Human physiology: from cells to systems / Lauralee Sherwood, Robert Kell. 1st Canadian ed. 2010. NJM Health Sciences Library RESERVE QT 104 S554ha 2010

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PHRM 1430: Applied Pathophysiology Schedule Lecture Location: 2nd Floor Lecture Theatre: Mondays & Wednesdays 9:00 - 10:30 AM TOPIC

Date

STUDY TOPICS

Jan 4

No Classes PDW Atherosclerosis and stable angina

Jan 9 Cardiovascular Disease

FACILITATOR

Jan 11

Acute Coronary Syndromes

Jan 16

Hypertension

Jan 18

Heart Failure

Dr. D. Turcotte

Dr. Namaka

Diabetes

Jan 23 & 25

Diabetes Type I and Type II

Gastrointestinal Disorders

Jan 30 & Feb 1

Ulcers/GERD

Feb 6 & 8

Depression/Sleep Disorders/ADHD

R. Thurmier

Schizophrenia & Bipolar

R. Thurmier

Dr. Namaka

Mental Illness

Dr. Namaka

Mental Illness

Feb 13

Neurology

Feb 15

Neuropathic Pain

Midterm Winter Break

Feb 20 - 24

No Classes

Midterm Exam Outside of Class TBA

Feb ??

All above topics prior to Feb 15th topics

Room TBA

Arthritis

Feb 27 & Mar 1

Rheumatoid Arthritis/ Osteoarthritis

Dr. Namaka

Nephrology

Mar 6 & 8

Chronic Kidney Disease I /Chronic Kidney Disease II

Dr. L. Wazny

Dermatology/ Oncology

Mar 13 & 15

Psoriasis/Epilepsy

Dr. Namaka

Respiratory Disorders

Mar 20

Asthma

Respiratory Disorders

Mar 22

COPD

Hepatic disease

Mar 27

Acute Hepatitis

Dr. H. Iacovides

Hepatic disease Neurology Disorders Neurology Disorders Final Exam (Covering Material from Feb 27 to Apr 5) – Non Cumulative from Midterm

Mar 29 Apr 3 Apr 5 Scheduled after last day of classes Apr 7

Cirrhosis Multiple Sclerosis Parkinson’s Disease

Dr. H. Iacovides Dr, Namaka Dr. Namaka

Time and Location TBA

Dr. Namaka

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Dr. Namaka Dr. Namaka