in Patients with Duchenne's Progressive Muscular Dystrophy. K. Mori,1 T. .... relaxation time, and deceleration time) and clinical variables (heart rate, age, and ...
Plasma Levels of Natriuretic Peptide and Echocardiographic Parameters in Patients with Duchenne's Progressive Muscular Dystrophy K. Mori,1 T. Manabe,1 M. Nii,1 Y. Hayabuchi,1 Y. Kuroda,1 K. Tatara2 1 Department of Pediatrics, School of Medicine, University of Tokushima, 3-18-15 Kuramoto-cho, Tokoshima-city, Tokushima, 770-8503, Japan 2
Department of Pediatrics, National Sanatorium Tokushima Hospital, Tokushima 770-8503, Japan
Abstract. We investigated the relationship between plasma atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) levels and systolic and diastolic cardiac function, determined by echocardiography, in 63 patients with Duchenne's progressive muscular dystrophy (DMD) (age range 8±21 years). The relationship between shortening fraction of the left ventricle and ANP and BNP levels was curvilinear rather than linear: When the shortening fraction was >15%, increases in ANP and BNP levels were minimal. However, if the shortening fraction was 15%, plasma levels of ANP and BNP were
