(POEM) in esophageal achalasia - BMC Gastroenterology - BioMed ...
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RESEARCH ARTICLE
Open Access
Improvement of endocytoscopic findings after per oral endoscopic myotomy (POEM) in esophageal achalasia; does POEM reduce the risk of developing esophageal carcinoma? Per oral endoscopic myotomy, endocytoscopy and carcinogenesis Hitomi Minami1, Naoyuki Yamaguchi1, Kayoko Matsushima1, Yuko Akazawa1, Ken Ohnita1, Fuminao Takeshima1, Toshiyuki Nakayama2, Tomayoshi Hayashi2, Haruhiro Inoue3, Kazuhiko Nakao1 and Hajime Isomoto1*
Abstract Background: Per oral endoscopic myotomy (POEM) has been reported to be a new therapeutic option for esophageal achalasia. The possibility that POEM could reduce the risk of developing esophageal squamous cell carcinoma was evaluated. Methods: This was a single-centre, retrospective study. Fifteen consecutive patients with esophageal achalasia who underwent POEM in our institution between August 2010 and January 2012 were enrolled. Ultra-high magnification with endocytoscopy was performed, and both histopathological and immunohistochemical evaluations for Ki-67 and p53 were assessed before and 3 months after POEM. Results: POEM was successfully performed and effectively released the dysphagia symptom in all patients without severe complications. Subjective symptoms (mean Ekcardt score, before 7.4 vs. after 0.5, p
