polio replicon replication total replication total replication ... - PLOS

2 downloads 0 Views 54KB Size Report
0. 2. 4. 6. 8. 10. 12. 14. 16. 0. 50000. 100000. 150000. 200000. siControl. ACSL1. ACSL3. ACSL4. ACSL6. BG2 polio replicon replication hours post transfection.
polio replicon replication

polio replicon replication

150000 100000

siControl FATP1 FATP3 FATP4 ACSL5

200000

50000

150000 100000

siControl FATP2 FATP5 FATP6 BG1

100000

50000

50000

0

0 12

14

16

0

2

4

hours post transfection

6

8

10

12

14

0

16

0

hours post transfection

total replication

100 80 60 40 20

140 120 100 80 60 40 20

G

2

0

140 100 80 60 40 20

1

40

si C on tr ol

SL 5 A C

TP 4 FA

TP 3 FA

TP 1 FA

B

6 C SL A

C SL A

C SL

si C on tr ol

0

G 2

0 4

20

0

3

20

1

20

A

B G

60

40

C SL

TP 6

80

1

60

100

B G

80

40

A

FA

si C on tr ol

SL 5 A C

TP 4 FA

TP 3 FA

TP 1

120

100

TP 6

60

140

120

FA

80

140

TP 2

100

160

FA

120

toxicity

160

% of control

% of control

140

on tr ol

14

0

FA

si C on tr ol

A

160

% of control

12

120

toxicity toxicity

si C

10

B

C

SL 6

SL 4 C

A

A

C

SL 3

SL 1 C A

si Co nt r

ol

0

8

160

% of control replication

% of control replication

120

6

total replication

160

140

4

hours post transfection

total replication

160

2

TP 5

10

FA

8

TP 5

6

FA

4

TP 2

2

FA

0

% of control replication

150000

renilla RLU

siControl ACSL1 ACSL3 ACSL4 ACSL6 BG2

polio replicon replication

250000

renilla RLU

renilla RLU

200000

16