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polio replicon replication total replication total replication ... - PLOS
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polio replicon replication total replication total replication ... - PLOS
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0. 2. 4. 6. 8. 10. 12. 14. 16. 0. 50000. 100000. 150000. 200000. siControl. ACSL1. ACSL3.
ACSL4
. ACSL6. BG2 polio replicon replication hours post transfection.
polio replicon replication
polio replicon replication
150000 100000
siControl FATP1 FATP3 FATP4 ACSL5
200000
50000
150000 100000
siControl FATP2 FATP5 FATP6 BG1
100000
50000
50000
0
0 12
14
16
0
2
4
hours post transfection
6
8
10
12
14
0
16
0
hours post transfection
total replication
100 80 60 40 20
140 120 100 80 60 40 20
G
2
0
140 100 80 60 40 20
1
40
si C on tr ol
SL 5 A C
TP 4 FA
TP 3 FA
TP 1 FA
B
6 C SL A
C SL A
C SL
si C on tr ol
0
G 2
0 4
20
0
3
20
1
20
A
B G
60
40
C SL
TP 6
80
1
60
100
B G
80
40
A
FA
si C on tr ol
SL 5 A C
TP 4 FA
TP 3 FA
TP 1
120
100
TP 6
60
140
120
FA
80
140
TP 2
100
160
FA
120
toxicity
160
% of control
% of control
140
on tr ol
14
0
FA
si C on tr ol
A
160
% of control
12
120
toxicity toxicity
si C
10
B
C
SL 6
SL 4 C
A
A
C
SL 3
SL 1 C A
si Co nt r
ol
0
8
160
% of control replication
% of control replication
120
6
total replication
160
140
4
hours post transfection
total replication
160
2
TP 5
10
FA
8
TP 5
6
FA
4
TP 2
2
FA
0
% of control replication
150000
renilla RLU
siControl ACSL1 ACSL3 ACSL4 ACSL6 BG2
polio replicon replication
250000
renilla RLU
renilla RLU
200000
16
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