postprandial emptying in patients with gall stones - NCBI

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Feb 9, 1993 - 20 Thompson JC, Fried GM, Ogden WD, Fagan FJ, Inoue K,. Weiner I, et al. ... In: Johnson LR, ed: Physiology of the gastrointestinal tract.

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Gut 1993; 34:1443-1447

Correlation between gall bladder fasting volume and postprandial emptying in patients with gall stones and healthy controls J Pauletzki, M Cicala, J Holl, T Sauerbruch, A Schafmayer, G Paumgartner Abstract To evaluate whether the extent ofpostprandial gall bladder emptying is correlated with gall bladder fasting volume, gail bladder motility was studied in 56 patients with cholesterol gall stone and 19 control patients. Gall bladder volumes were determined sonographicaily, while cholecystokinin plasma values were measured radioimmunologicaliy. Twenty three per cent of gail stone patients were classified as pathological contractors (residual fraction >mean +2SD of controls) and 77% as normal contractors. Normal but not pathological contractor patients exhibited larger gall bladder fasting volumes (mean (SEM)) (24-7 (1.7) ml) than controls (15.3 (1.2) ml, p85 normal contractor patients exhibit distinctly 6 eco. O. larger residual volumes than controls. This 0 L retention of bile in the gall bladder in most gall 'IL o. '0 50- 55 60 65 stone patients may facilitate the nucleation of 5 10 15 20 25 30 35 40 45 v0-) CL cholesterol crystals and stone growth. Whereas cJ FV (ml) increased residual volumes may be the final Controls consequence of changed gall bladder motility in Normal contractor patients lI cholesterol gall stone disease the results of our Pathological contractor patients study point to different underlying mechanisms Figure 4: Correlation offasting volume (FV) of the gall bladder and postprandial residual in various subgroups of patients. In pathological volume (RV) in normal contractor gall stone patients (0) and controls (0). Pathological contractor patients without cholecystitis contractor patients shown by (-). .....

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Pauletzki, Cicala, Holl, Sauerbruch, Schafmayer, Paumgartner

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TABLE II Gall bladder emptying after a standard liquid test meal in gall stone patients and controls Gall stone patients

FV (ml) RV (ml) RF (%) EV(ml) EV' (ml)

Normal contractors n=43

Pathological contractors n=13

All n=56

Controls n=19

p Values

(1)

(2)

(3)

(4)

(1-2)

(1-4)

(2-4)

(3-4)

24-7 (1-7) 7 0 (0 5) 29 (1) 17-7(1-3) 14-9(1-2)

19-6 (2 5) 12-7 (1-5) 69 (6)

23-6 (1-5) 8 3 (0-6) 38 (3) 15-2(1-2) 12-5(1-1)

15-3 (1-2) 4-6 (0 6) 30 (2) 10-7 (0-8) 10-6 (08)

NS p=0-02 p

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