Four SICA project meeting. Imperial College, London, 24 May 2013. Florin Grigorescu MD, PhD ... Consortium. Taragona. Ca
Four SICA project meeting Imperial College, London, 24 May 2013
Genetic and environmental factors of Metabolic Syndrome in Mediterranean populations Florin Grigorescu MD, PhD (France)
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Modern migrations (immigrants) MEDIGENE populations Albanese (Illyrians), Turkish (Altaic populations with Central Asians components), Romanian (Geto-Thracic populations from the Carpato-Danubian basin), North African immigrants (Berbers admixed with Bedouin tribes or Canaanite-Phoenicians in historical times) - Algerians, Tunisians and Moroccans.
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Relationship between migration and health Vulnerable populations
Statistically immortal Selection theory
Epi-genetics Contact 1st Gen
Home
Salmon theory
Genetic background ?
Host (Natives) 2nd Gen
Epidemiological paradoxes
Refugee Age of migration
Acculturation Life style
Stress
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Working packages WP1 1st STAGE GWAS 600 000 SNPs
Available DNA
WP2 Ancient DNA study In historical Romans Ancient DNA
WP3 Locus refining •
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WP4 1st STAGE analysis CC association in host countries Filtered SNPs
New DNA sampling
WP5 Epidemiology in host and home countries & novel recruitment for G x E interaction Rare SNPs WP6 2nd STAGE - Replication Genotyping with filtered SNPs
WP7 2nd stage analysis and meta-analysis
Replication
WP8 Replication in Home countries
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Consortium
Clinical endocrinologists and geneticists, anthropologists, demographist & archaeologists Florin Grigorescu (CO), Michel Pugeat, Ramon Gomis, Josep M. M acias, Mihai Coculescu, Renato Pasquali, Giorgio Sesti, Vincenzo Trischitta, Davide Lauro, Agathocles Tsatsoulis, Elza Khusnutdinova, Sonia Abdelhak, Akila Zenati, Abdelhamid Barakat, IIly Agron, Timo Kanninen, Robert Hermann, Ilhan Satman Rhône Alpes
Coordination Montpellier 3
Moldova 5 Bologna 1
Taragona Barcelona
CIBERDEM 2
Casablanca
IPM 14
13
Alger
Oufa IBG 10
Tirana Bucharest 4 15 Rome 7, 8 Istambul Cantazaro 9 11 6 Ioannina
IPT Tunis 12
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