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Julianne Bayliss*1,2, Catherine L Cherry1,3,4 & Catriona A McLean1,5 Department of Medicine, Monash University, Alfred Hospital, Melbourne, VIC 3004, Australia Division of Molecular Research & Development, Victorian Infectious Diseases Reference Laboratory, North Melbourne, VIC 3051, Australia 3 Centre for Virology, Burnet Institute, Melbourne, VIC 3004, Australia 4 Infectious Diseases Unit, Alfred Hospital, Melbourne, VIC 3004, Australia 5 Anatomical Pathology, Alfred Hospital, Melbourne, VIC 3004, Australia *Author for correspondence: Tel.: +61 3 8506 2495 n Fax: +61 3 9282 2126 n
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Aims: HIV-1 infection represents the most common immunosuppressive condition associated with progressive multifocal leukoencephalopathy (PML). Materials & methods: Nested PCR and quantitative real-time PCR (qPCR) for JC virus (JCV) DNA was performed on serial plasma samples obtained from 14 HIV patients with PML and 27 matched controls. Results: JCV large T antigen (LT) DNA was detected via qPCR in 11 out of 14 (79%) PML patients at disease onset and four out of 27 (15%) controls (p
