orthotopic liver transplantation (OLT) in Switzerland between 1990 and 2002 showed that these children were not well immunized and therefore not enough ...
A successful intervention to increase protection against vaccine-preventable diseases in liver transplanted children: A 19-yr review of the Swiss national reference center
L’Huillier AG, Diana A, Belli DC, Wildhaber BE, Rodriguez M, Siegrist CA, Posfay-Barbe KM June 17, 2010 – SGP/SSP congress
L’Huillier AG & al
Background and aims • A review of vaccine strategies offered to all children with orthotopic liver transplantation (OLT) in Switzerland between 1990 and 2002 showed that these children were not well immunized and therefore not enough protected against vaccine-preventable diseases à the authors established new recommendations • We analyzed the impact of the new recommendations by comparing vaccine coverage and protection in the
Ø pre-intervention cohort (1990-2002, P1) AND
Ø post-intervention cohort (2003-2008, P2) •Diana, A., et al., Vaccine-induced immunity in children after orthotopic liver transplantation: a 12-yr review of the Swiss national reference center. Pediatr Transplant, 2007. 11(1): p. 31-7. •Diana, A., Etude de l'immunité vaccinale chez les enfants ayant bénéficié d'une transplantation hépatique à genève entre 1990 et 2002, in Department of Pediatrics. 2004, Thesis, Geneva Medical School and University Hospitals of Geneva: L’Huillier AG & al
Methods • Geneva Children’s Hospital = national reference center for liver transplantation All OLT candidates are referred for preOLT assessment, OLT and followup at 3, 6, 12 months, and then yearly
• Serological analyses: D, T, Pneumo14/19/23, HAV, HBV, VZV, MMR
• Live attenuated vaccines NOT RECOMMENDED if patient on waiting list à OK if >1month before OLT
• “Vaccine on schedule”: Definition “On schedule” if vaccine received
