Apr 28, 2015 - clinics of the Philippine general hospital. Lalaine Audrey Matitu-Untalan*, Sylvia C Estrada. From 8th APPES Biennial Scientific Meeting.
Matitu-Untalan and Estrada International Journal of Pediatric Endocrinology 2015, 2015(Suppl 1):P101 http://www.ijpeonline.com/content/2015/S1/P101
POSTER PRESENTATION
Open Access
Prevalence of thyroid disorders among children with Down syndrome seen in the out-patient clinics of the Philippine general hospital Lalaine Audrey Matitu-Untalan*, Sylvia C Estrada From 8th APPES Biennial Scientific Meeting Darwin, Australia. 29 October – 1 November 2014 Background Thyroid disorders are noted to occur in 28–40% of children with Down syndrome [1]. Hypothyroidism has a subtle presentation and can be particularly challenging to detect in patients with intellectual disabilities and communication and language impairments [2]. Regular screening and early diagnosis of thyroid disorders, particularly hypothyroidism, is essential for early intervention. Objective To determine the prevalence of thyroid disorders among children with Down Syndrome (DS) seen in the outpatient clinics of the Philippine General Hospital from January 2007 to December 2011. Secondary objectives To classify the thyroid disorders present; to describe the clinical profiles and genotype of the children with Down syndrome. Methodology A Retrospective chart review of all patients with Down syndrome seen in the Out-patient Clinics of the Philippine General Hospital from January 2007 to December 2011.
consult was 2.38 (±3.14) years. The mean age of mothers at childbirth was 34.23 (±6.77) years. The most common co-morbid illness was congenital heart disease (46%, 41/89). The most common chromosomal abnormality was full trisomy 21 (95.51%, 85/89).
Conclusion Fifty-six percent of children with Down syndrome in this study have thyroid disorders, with subclinical hypothyroidism being the most common. This study provides evidence for the need of regular monitoring of thyroid function test among children with DS. Published: 28 April 2015 References 1. Weijerman M, de Winter J P: Clinical practice. The care of children with Down syndrome. Eur J Pediatr 2010, 169:1445-1452. 2. Carroll K, et al: Increase in Incidence of Medically Treated Thyroid Disease in Children With Down Syndrome After Rerelease of American Academy of Pediatrics Health Supervision Guidelines. PEDIATRICS 2008, 122(2): e493-e498. doi:10.1186/1687-9856-2015-S1-P101 Cite this article as: Matitu-Untalan and Estrada: Prevalence of thyroid disorders among children with Down syndrome seen in the out-patient clinics of the Philippine general hospital. International Journal of Pediatric Endocrinology 2015 2015(Suppl 1):P101.
