Primary Biliary Cirrhosis Associated with MembranousGlomerulonephritis
Takashi Goto, Masafumi Komatsu, TomooFinn, Shigetoshi Ohshima, Kunio Nakane, Kazuo Yoneyama, TomomiShibuya, Xiang Wei Meng, Osamu Masamune and Hirokazu Imai* A 33-year-old womanwas admitted to our department for evaluation of liver dysfunction and proteinuria. A liver biopsy specimen showed ductular proliferation and moderate portal fibrosis indicating stage II primary biliary cirrhosis. A renal biopsy specimen showed mild to moderate mesangial cell proliferation without crescent formation or interstitial nephritis. Immunofluorescent staining revealed deposition of immunoglobulin G (IgG), third component of complement (C3), and Clq on glomerular basement membranes. The findings indicated stage I membranous glomerulonephritis. Administration of ursodesoxycholic acid together with prednisolone, azathioprine, and dipyridamole decreased proteinuria and improved cholestatic liver dysfunction. (Internal
Medicine 38: 22-26, 1999)
Key words: antimitochondrial
M2 antibody, proteinuria,
Introduction
immunofluorescent staining
noglobulin (Ig) Mconcentration of 634 mg/dl (normal, 57 to 303), and antimitochondrial M2 antibody, 1 ,230 U/ml (normal,
