PRODUCT DATA SHEET 11-Apr-2016
AG-MR-C0020
7BIO [7-Bromoindirubin-3'-oxime]
AG-MR-C0020-M010 AG-MR-C0020-M050
10 mg 50 mg
Formula MW CAS
C16H10BrN3O2 356.2 916440-85-2
Handling / Storage Shipping Short Term Storage Long Term Storage
AMBIENT +4°C -20°C
Keep cool and dry. Protect from light and moisture. Use / Stability Stable for at least 2 years after receipt when stored at -20°C. MSDS available at www.adipogen.com or upon request.
Product Specifications Purity Identity Appearance Solubility Reconstitution
≥99% (NMR) Determined by 1H-NMR. Dark red solid. Soluble in DMSO or ethanol. Stock solutions can be made up to 10mM in DMSO.
Product Description • Anticancer compound. • Caspase-independent, non-apoptotic cell death inducer. • ATP-competitive Flt3 inhibitor. • Necrosis inducer. • Aurora B and C kinase inhibitor. • DYRK1A and DYRK 2 (Dual-specificity tyrosine phosphorylation-regulated kinase) inhibitor.
WARNING: Intended for research use only. This product is not intended or approved for human, diagnostics, therapeutic or veterinary use. Use of this product for human or animal testing is extremely hazardous and may result in disease, severe injury, or death. MATERIAL SAFETY DATA: Review the complete Material Safety Data Sheet before use.
North/South America:
Adipogen Corp. 9853 Pacific Heights Blvd., Suite L San Diego, CA 92121-4721 USA TEL (858) 457-8383 FAX (858) 457-8484
[email protected]
Rest of World:
Adipogen AG Schützenstrasse 12 4410 Liestal Switzerland TEL +41-61-926-60-40 FAX +41-61-926-60-49
[email protected]
For Local Distributors please visit
www.adipogen.com
PRODUCT DATA SHEET • Inflammasome activator.
Product Specific References 1. Indirubin, the red shade of indigo: L. Meijer, et al. (Editors): In «Life in Progress», Station Biologique, Roscoff, 297 pp. (2006) 2. 3'-substituted 7-Halogenoindirubins, a new class of cell death inducing agents: Y. Ferandin, et al.; J. Med. Chem. 49, 4638 (2006) 3. 7-Bromoindirubin-3'-oxime induces caspase-independent cell death: J. Ribas, et al.; Oncogene 25, 6304 (2008) 4. Inverse in silico screening for identification of kinase inhibitor targets: S. Zahler, et al.; Chem. Biol. 14, 1207 (2007) 5. An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins: V. Myrianthopoulos, et al.; J. Med. Chem. 50, 4027 (2007) 6. 7-Bromoindirubin-3'-oxime uncovers a serine protease-mediated paradigm of necrotic cell death: J. Ribas, et al.; Biochem. Pharmacol. 76, 39 (2008) 7. Cutting edge: Necrosis activates the NLRP3 inflammasome: H. Li, et al.; J. Immunol. 183, 1528 (2009) 8. Anticancer effects and antimetastatic mechanisms of novel indirubin derivatives: C.A. Kressirer; Diss. LudwigMaximilians-Universitaet Munchen, (2010) 9. Induction of discrete apoptotic pathways by bromo-substituted indirubin derivatives in invasive breast cancer cells: K.A. Nicolaou, et al.; BBRC 425, 76 (2012) 10. From Tyrian purple to kinase modulators: naturally halogenated indirubins and synthetic analogues: K. Vougogiannopoulou & AL. Skaltsounis; Planta Med. 78, 1518 (2012) 11. A novel 7-bromoindirubin with potent anticancer activity suppresses survival of human melanoma cells associated with inhibition of STAT3 and Akt signaling: L. Liu, et al.; Cancer Biol. Ther. 13, 1255 (2012) 12. Novel inverse binding mode of indirubin derivatives yields improved selectivity for DYRK kinases: V. Myrianthopoulos, et al.; ACS Med. Chem. Lett. 4, 22 (2013)
WARNING: Intended for research use only. This product is not intended or approved for human, diagnostics, therapeutic or veterinary use. Use of this product for human or animal testing is extremely hazardous and may result in disease, severe injury, or death. MATERIAL SAFETY DATA: Review the complete Material Safety Data Sheet before use.
North/South America:
Adipogen Corp. 9853 Pacific Heights Blvd., Suite L San Diego, CA 92121-4721 USA TEL (858) 457-8383 FAX (858) 457-8484
[email protected]
Rest of World:
Adipogen AG Schützenstrasse 12 4410 Liestal Switzerland TEL +41-61-926-60-40 FAX +41-61-926-60-49
[email protected]
For Local Distributors please visit
www.adipogen.com
