vivo studies for the role of genes involved in apoptosis (Bcl-. 2 and p53) in ovarian ..... survival was seen in women with a p53 gene mutation, which subsequently ... analysis, Mrs. Antigone Christodoulou for excellent technical assistance and ...
ANTICANCER RESEARCH 27: 1157-1166 (2007)
Prognostic Significance of HER-2, p53 and Bcl-2 in Patients with Epithelial Ovarian Cancer VASSILIKI MALAMOU-MITSI1, OLGA CRIKONI1, ELENI TIMOTHEADOU2, GERASSIMOS ARAVANTINOS3, ELENI VRETTOU2, NIKI AGNANTIS1 and GEORGE FOUNTZILAS2 1Department
of Pathology, University of Ioannina School of Medicine, Ioannina; of Medical Oncology "Papageorgiou" General Hospital, Aristotle University of Thessaloniki School of Medicine, Thessaloniki; 3"Agii Anargiri" Cancer Hospital, Athens, Greece 2Department
Abstract. Background: Several oncogenes and onco-suppressor genes have been implicated in epithelial ovarian carcinogenesis, but their clinical significance is not clear and conflicting data have been found in various studies. Patients and Methods: The immunohistochemical expression of HER-2, p53 and Bcl-2 proteins was investigated in a cohort of 95 patients with advanced epithelial ovarian cancer (stages IIc-IV). These patients participated in a phase III randomized clinical trial and were treated either with paclitaxel/carboplatin, or paclitaxel/carboplatin alternating with paclitaxel/cisplatin. Results: Positive immunostaining for HER-2, p53 and Bcl-2 proteins was found in 18%, 70.5% and 69.5% of the cases, respectively. In multivariate analysis, older patients (
