program - Le Public SystÃ¨me

PROGRAM

TABLE OF CONTENTS

Welcome from the 2014 Conference Organizing Chair

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Welcome from the IFPA President

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Program at a glance

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Committees Speakers biographies Detailed program Business Meeting Schedule

5-6 7 - 17 18 - 22 23

Workshops

24 - 29

IFPA Awards

30 - 32

General information

33 - 38

Social program

39 - 40

Poster Session 1

42 - 58

Poster Session 2

59 - 76

IFPA - EPG 2014 - Paris

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Welcome from the 2014 Conference Organizing Chair Dear delegates, I am very happy to welcome delegates from all around the world to the annual meeting of the International Federation of Placenta Associations (IFPA). Every third year, this meeting is organized in Europe, in association with the European Placenta Group (EPG). The meeting is held in the historical University setting, Les Cordeliers, in the latin quarter of Paris, my loved city of birth. This site hosted «le club des Cordeliers», a famous political club, who imagined in 1791 the French moto «Liberté, Egalité, Fraternité». This setting will allow young investigators but also veterans to share the student life in Paris. It will offer a favorable environment for developing new research ideas around the topic of the meeting devoted to fetal-placental-maternal crosstalk and pregnancy outcome. The preparation of this meeting was a long way starting in Geilo 2011. I want to express my sincere gratitude to the local organizing and scientific committee also called «the best French Team» and to the organizers of the workshops. I thank the president of IFPA, all of the members in the international scientific committee who have contributed in the planning of the Paris meeting and evaluated the scientific abstracts for IFPA setting 2014. Let’s make les Cordeliers stand for a bright moment in placenta research! Let’s make Paris stand for an unforgettable moment in your life! Enjoy IFPA 2014!

Bien amicalement Danièle Evain-Brion MD, PhD Chair IFPA 2014


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Welcome from the IFPA President Dear Friends and Colleagues in IFPA,

As President of the International Federation of Placenta Associations it is my great pleasure to welcome you to our 2014 scientific meeting, hosted by Dr. Danièle EvainBrion and her team, acting for the Europe Placenta Group. This promises to be an exciting and most memorable meeting. Set in the historical Left Bank of Paris, we can look forward to a phenomenal array of speakers addressing cutting-edge science. We can look forward to exosomes, placental stem cells, imaging of the vasculature, trophoblast fusion, invasion, differentiation and much, much more. While these meetings can seem all too short for the science being presented, remember that the presentations are only a part of the meeting. It has long been our tradition to take time to meet, interact, discuss and set up new collaborations in the meeting rooms, hotels, bars and restaurants. We are especially glad to have so many new investigators at this meeting, more than 175, and we hope you will enjoy and benefit from this meeting. My plea to you is to use one of the important resources of this meeting, the experience and expertise of the senior investigators. Talk to them and ask questions – they are all happy to help. Our senior investigators welcome all our new investigators. Your attendance at this meeting makes you a member of IFPA. As a growing organization, IFPA needs your input on the vision for our organization and the future directions to take. It is important therefore that you partake in the functioning of IFPA and I invite you to attend our Annual General Meeting (Thursday, Sep 11th, 4:15 pm) and help us to guide IFPA forward. I know you will appreciate this meeting and the beautiful surroundings. I know you will enjoy the social activities and make new friends from across the globe. We expect to see you again in Brisbane in 2015. Meanwhile, enjoy the science, the scientists and Paris! Nick Illsley President, IFPA


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PROGRAM AT A GLANCE THUESDAY 9TH SEPTEMBER

Welcome

IFPA Executive meeting 09:00 - 13:00 Thesis Room

IFPA Executive lunch 13:00 - 15:30 Restaurant «Le Procope»

Welcome address & Plenary Session 1 15:30 - 17:30 Farabeuf Amphi

WEDNESDAY 10TH SEPTEMBER

THURSDAY 11TH SEPTEMBER

Welcome

Welcome

Awards committee 08:00 - 09:00 Thesis Room

Placenta/Trophoblast Research Editorial board 08:00 - 09:00 Thesis Room

Welcome

Plenary session 2: Placental hormones 09:00 - 10:30 Farabeuf Amphi

Plenary session 3: Focus on trophoblast cell biology 09:00 - 10:30 Farabeuf Amphi

Plenary session 4: EPG Mid-career investigators 09:00 - 11:00 Farabeuf Amphi

Coffee break - Marie-Curie Room


New Investigators Session 1 11:00 - 12:15 Farabeuf Amphi

New Investigators Session 2 11:00 - 12:15 Farabeuf Amphi

The Elsevier Trophoblast Research Award Lecture 12:15 - 12:40 Farabeuf Amphi

Gabor Than Award 12:15 - 12:40 Farabeuf Amphi

Lunch 12:40 - 13:45 Marie-Curie Room

Lunch 12:45 - 13:45 Marie-Curie Room

Workshops 13:45 - 16:15

Workshops 13:45 - 16:15

1. Placental imaging: Amphi Roussy 2. Pregnancy pathologies: Amphi Farabeuf 3. Animal models: Amphi Pasquier

4. Genetics & epigenetics: Amphi Pasquier 5. Placenta and stillbirth: Amphi Farabeuf 6. Human placenta & xenobiotics: Amphi Roussy

New investigators organized session & Regional Business Meeting 16:15 - 17:30 Farabeuf Amphi

IFPA Business Meeting & New investigators organized session 16:15 - 17:30 Farabeuf Amphi

Poster session 1 Around Champagne 17:30 - 19:30 Les Cordeliers

Poster session 2 Wine and cheese 17:30 - 19:30 Les Cordeliers

FRIDAY 12TH SEPTEMBER


NIH Sponsored lecture (11:30 - 12:30) Interest of large cohorts (12:30 - 13:00) Farabeuf Amphi Lunch 12:45 - 13:45 Marie-Curie Room Plenary session 5 : The fetus IUGR and the placenta 14:00 - 15:00 Placental destiny through ages and culture 15:00 - 15:30 Farabeuf Amphi Senior IFPA Award in placentology 15:30 - 16:30 Farabeuf Amphi

Free time

Free time

Opening Reception 18:30 - 23:00 Town Hall


Gala dinner 19:00 - 23:00 Cruise on the Seine

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COMMITTEES Local organizing committee Danièle EVAIN-BRION, MD, PhD Organizing chair of IFPA 2014 Jean GUIBOURDENCHE, PharmD, PhD

International advisory committee Pascale CHAVATTE-PALMER, DVM, PhD France Claire ROBERTS, PhD Australia Leslie MAYATT, PhD USA

Awards committee Estela BEVILACQUA, PhD, University of São Paulo, Brazil Chair of the (new investigator) oral judging committee Chair of the IFPA awards committee Theresa POWELL, PhD, University of San Antonio, USA Chair of the (new investigator) poster judging committee

International scientific committee (abstract review committee) Nadia Alfaidy, PhD, MSc, HDR INSERM, Université Joseph Fourier, Grenoble, France

Marie Cohen, PhD Faculty of Medicine Geneva, Geneva, Switzerland

Denise G. Hemmings, PhD University of Alberta, Edmonton, Canada

Estela Bevilacqua, PhD University of São Paulo, São Paulo, Brazil

James Cross, DVM, PhD University of Calgary, Calgary, Canada

Berthold Huppertz, PhD University of Graz, Graz, Austria

Anne-Lise Delezoide, MD, PhD Université Paris Diderot, Paris, France

John Kingdom, MD University of Toronto, Toronto, Canada

Gernot Desoye, PhD University of Graz, Graz, Austria

Martin Knöfler, PhD Medical University Vienna, Vienna, Austria

Graham Burton, MD, DSc University of Cambridge, Cambridge, United Kingdom Isabella Caniggia, MD, PhD University of Toronto, Toronto, Canada Anthony M. Carter, PhD University of Southern Denmark, Odense, Denmark Irène Cetin, MD University of Milano, Milano, Italy Larry Chamley, PhD University of Auckland, Auckland, New Zealand Pascale Chavatte-Palmer, DVM, PhD INRA, Jouy-en-Josas, France Vicky Clifton, PhD University of Adelaide, Adelaide, Australia


Marie-Noëlle Dieudonné, PhD Université Versailles Saint Quentin, France Thierry Fournier, PhD INSERM, Université Paris Descartes, Paris, France Sophie Gil, PhD Université Paris Descartes, Paris, France

Lopa Leach, PhD University of Nottingham, Nottingham, United Kingdom Philippe Lebouteiller, PhD INSERM, Université de Toulouse, France Nathalie Ledee, MD, PhD Université Paris-Diderot, Paris, France

Thaddeus G. Golos, PhD University of Wisconsin-Madison, Madison, Wisconsin, USA

Fiona Lyall, MBA, PhD University of Glasgow, Glasgow, United Kingdom

Jean Guibourdenche, PharmD, PhD Université Paris Descartes, Paris, France

Ashley Moffet, MD,PhD University of Cambridge, United Kingdom

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COMMITTEES International scientific committee (abstract review committee) Padma Murthi, MSc., PhD University of Melbourne, Melbourne, Australia

Vincent Sapin, PharmD, PhD Université d’Auvergne, Clermont-Ferrand, France

Leslie Myatt, PhD University of Texas, San Antonio, Texas, USA

Anne Cathrine Staff, MD, PhD University of Oslo, Oslo, Norway

Christiane Pfarrer, DVM, PhD University of Veterinary Medicine, Hanover, Germany Guillaume Pidoux, PhD INSERM, Université Paris Descartes, Paris, France Claire Roberts, PhD University of Adelaide, Adelaide, Australia Alessandro Rolfo, PhD University of Turin, Turin, Italy Yoël Sadovsky, MD University of Pittsburg, Pittsburg, USA Richard Saffery, PhD University of Melbourne, Melbourne, Australia Norimasa Sagawa, MD, PhD General Women’s Medical and Health Science Center, Rakuwakai Otowa Hospital, Kyoto, Japan

Anne Tarrade, PhD INRA, Jouy-en-Josas, France Vassilis Tsatsaris, MD, PhD Université Paris Descartes, Paris, France Cathy Vaillancourt, PhD Université du Québec, Laval, Canada Daniel Vaiman, PhD INSERM, Université Paris Descartes, Paris, France Anne Vambergue, MD, PhD Université de Lille 2, Lille, France Aureo Yamada, PhD University of Campinas, SP, Brazil Stacy Zamudio, PhD Hackensack University Medical Center, NJ, USA

Shigeru Saito, PhD University of Toyama, Toyama, Japan


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SPEAKERS BIOGRAPHIES Mahroo AGHABABAEI I am pursuing my Masters in the department of Obstetrics and Gynaecology at the University of British Columbia, Vancouver, Canada. After finishing high school in Iran, I moved to Canada to further my studies. I completed my undergraduate degree in Honors Science (2011) at the University of Waterloo, Canada. In 2012, I joined Dr. Alexander Beristain’s laboratory at the Child and Family Research Institute, Vancouver, Canada. My research examines the cellular mechanisms critical to the early development of the placenta. Specifically, my work investigates the importance of a specific gene member of the ADAM family of metalloproteinase in directing trophoblast invasion and formation of anchoring trophoblast columns. These are the two key processes fundamental to the successful establishment of the early placenta. Upon completion of my master’s degree, I am planning to further continue my education in a combined MD/PhD program. In 2013, I was awarded the Y.W. (Charlie) Loke Travel Award for Early Career Researchers and the Elsevier Trophoblast Research New Investigator Award for the best poster presentation by a new investigator at the IFPA Annual Conference. Contact: University of British Columbia, Child and Family Research Institute, Vancouver, Canada Phone: +1 60 47 82 67 22 Email: [email protected]

Alexandre BONNIN Alexandre Bonnin is Assistant Professor in the department of Cell and Neurobiology at the University of Southern California. His research explores maternal-fetal interactions contribution to shaping fetal brain development during pregnancy. In particular, he focuses on understanding how the placental function affects fetal brain circuit development, identifying new molecular pathways by which prenatal events influence the onset of mental diseases in the adult offspring. These efforts will provide new directions to study the developmental origin of mental health-related disorders such as autism and schizophrenia in humans. Dr Bonnin received his PhD in neuroscience from the University of Paris and the Pasteur Institute in France. He completed postdoctoral fellowships in neurobiology at the University of California Irvine and at Vanderbilt University (USA) before joining the University of Southern California as an assistant professor in 2011. Dr Bonnin was awarded several Young Investigator Awards by the Brain & Behavior Research Foundation and is the recipient of a 2011 Daniel X. Freedman Awardfor outstanding basic research achievement. For his research, Dr Bonnin is receiving funding from the NIH and the Department of Defense.His current research focuses on maternal and environmental factors that alter serotonin availability in placental and fetal compartments, and their effects on fetal brain wiring and long-term consequences on adult offspring brain function. He developed a new technology to study the molecular, neurochemical and metabolic details of the maternalfetal interaction in mice. This technology, based on the ex vivo dual perfusion of live mouse placentas at different stages of gestation, allows testing how changes in placental metabolism impact the supply of serotonin and other important neurogenic molecules to the fetus during early brain development. This expertise also provides unique opportunities to measure placental metabolism and maternal-fetal transfer of various therapeutic agents throughout gestation. Contact: ZilkhaNeurogenetic Institute - Dept. Cell & Neurobiology - Keck School of Medicine of University of Southern California - 1501 San Pablo Street, Room 429 Los Angeles, CA 90089-2821, USA Phone: +1 32 34 42 29 86 Email: [email protected]


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SPEAKERS BIOGRAPHIES Alain BRISSON Alain Brisson has successively led research groups at the University of Strasbourg (1987-94) as Directeur de Recherche at INSERM, at the University of Groningen (1994-2001) as Professor of Chemistry, and currently in Bordeaux as Professor at the University of Bordeaux. His main research projects concern the role of Annexin-A5 in membrane repair, and the field of membrane microvesicles, their role in physio-pathological processes and their applications as disease biomarkers. His group has expertise in cryo-Electron Microscopy imaging, protein chemistry, flow cytometry and nanoparticle synthesis. Contact: UMR-CBMN, CNRS – University of Bordeaux Phone: +33 5 40 00 68 61 Email: [email protected]

Sylvie EPELBOIN Sylvie Epelboin, MD, is a gynecologist and obstetrician specializing in reproductive medicine. Since 1984, she is the head of the unit of Reproductive Medicine of Saint Vincent de Paul Hospital, Paris, and now that of Bichat -Claude Bernard, Paris -Diderot University. Her work in this area mainly interested specificities of pregnancies and births after Assisted Reproductive Technologies (ART), including vascular, trophoblastic and placental pathologies responsible for miscarriages or intrauterine growth retardation following uterine assisted conceptions, and the health and development of children who are born from reproductive techniques. Along with her medical course , she has been involved for many years in the field of social sciences , first realizing her thesis within a team from the French Museum of Man in African populations on the subject of representations of infertility and pregnancy in traditional environment , as symbolic and therapeutic uses of the placenta over the centuries and in different cultures; then in participating in the development of Psychosomatic obstetrics and Gynecology Society, as publishing a history of women’s blood from puberty to menopause, considering delivery and placental hemorrhage. She was soon invested in ethical debates around new techniques of human reproduction, graduate in medical and biological ethics on the subject of supply and demand for ART, founding member of the Center for Clinical Ethics in Paris- Cochin. Since the early 90s, she taught in several academic institutions in the field of permanent renewal of ethical issues throughout the advancement of medical knowledge in reproductive technologies. Contact: Gynecological department, Hôpital Bichat Claude Bernard, 46 rue Henri Huchard, 75018, Paris, France Email: [email protected]


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SPEAKERS BIOGRAPHIES Susan FISHER Susan Fisher, PhD, is a Professor in the Dept. of Obstetrics, Gynecology and Reproductive Sciences, School of Medicine, University of California, San Francisco (UCSF). She is jointly appointed in the Dept. of Anatomy. Dr. Fisher is the Director of the UCSF Human Embryonic Stem Cell Program and Faculty Director of the Sandler-Moore Mass Spectrometry Core Facility. Dr. Fisher received her Bachelor of Science degree in biology and chemistry from Hope College, Holland, Michigan, and her Ph.D. in anatomy from the University of Kentucky, Lexington, Kentucky. She completed a five-year postdoctoral fellowship in mass spectrometry at the latter institution. She joined UCSF in 1982. Recent awards include: 2011, Fellow of the American Association for the Advancement of Science; 2012, Nina B. Schwarz Lectureship, Northwestern University; 2012, Honorary Bingzhi Forum Professorship, Institute of Zoology, Chinese Academy of Sciences; 2013 MERIT award (NICHD); and 2013, Frontiers in Reproduction Research Program Pioneer Award (NIH, MBL and Burroughs Welcome). The Fisher group works in three areas. The first is reproductive biology, focusing on the human placenta. They are studying the mechanisms that human cytotrophoblasts use to invade the uterus and the resident arterioles in normal pregnancy and the defects in this process that are associated with preeclampsia. Second, the Fisher laboratory studies the initial steps of human embryonic and extraembryonic development using human embryos and human embryonic stem cell models. Third, a portion of the Fisher group uses mass spectrometry tools and functional glycomics and proteomics approaches to investigate many normal vs. disease states including endometriosis, cystic fibrosis, Sjögren’s syndrome and breast cancer. Contact: Department of Obstetrics, Gynecology and Reproductive Sciences, School of Medicine, University of California, San Francisco (UCSF) Email: [email protected]


Thierry FOURNIER After a Master in Toxicology (Paris VII, France), Thierry Fournier obtained his Ph.D. in Molecular Biology from the University of Paris XI, France. His thesis focused on regulation of acute phase protein gene expression by xenobiotics, nuclear receptors and cytokines. Then, he was trained as a post-doctoral fellow in Dr Peter Henson’s lab at the National Jewish Center for Immunology and Respiratory Diseases (NJC) in Denver Colorado where he investigated the mechanisms involved in generating macrophage diversity. Back to France, he obtained a permanent position of basic scientist at the Inserm (French National Institute for Health and Medical Research). From 2000, he has been working in Daniele Evain-Brion’s laboratory located at the Faculty of Pharmacy in Paris. He has been studying the role of the nuclear receptor PPARg and its target genes in trophoblast differentiation during early human placental development. Dr. Fournier is now Research Director and currently leader of the Unit « Patho Physiology & Pharmaco Toxicology of the Human Placenta» (UMR-S 1139 InsermUniversity of Paris Descartes). His team studies the impact of the placenta environment in both physiological and pathological conditions on the formation, integrity, exchange and hormonal functions of the chorionic villous. The general goal of the team is to obtain better knowledge of human placental development and function in normal and pathological conditions in order to improve early screening (biomarkers, imaging) and care of the main obstetrical diseases associated with placental dysfunction. Thierry Fournier is a member of the network (RTRS pregnancy and prematurity) and of the PremUp Foundation and co-funded in 2012 with Dr Cathy Vaillancourt and Dr Marie Cohen, the first international “Francophone Placental Group” (GfP). Contact: UMR-S 1139 Inserm-University of Paris Descartes, Paris, France Phone: +33 1 53 73 96 00 Email: [email protected]

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SPEAKERS BIOGRAPHIES Abigail FOWDEN Abby Fowden is Professor of Perinatal Physiology in the Department of Physiology, Development and Neuroscience, University of Cambridge. She was an undergraduate at Girton College and graduated with a first class degree in Physiology in 1975. She obtained her PhD from the University of Cambridge in 1979 and immediately joined the staff of the Department of Physiology as a demonstrator. Since then, she has held positions as a University Lecturer and Reader before being promoted to a personal chair in 2002. She obtained the ScD degree in 2001 and was awarded the Joan Mott Prize of the Physiological Society for her research in 2008. Her research interests are in the factors controlling feto-placental growth and development during late pregnancy. The aims of her research are two fold: first, to determine how hormones and other environmental cues regulate feto-placental development and, secondly, to establish how our experiences during early life alter the risk of degenerative diseases in adulthood. She is also a Professorial Fellow at Girton College, Cambridge.

Alexander HEAZELL

Dr Alexander Heazell is a Senior Clinical Lecturer in Obstetrics working at the Maternal and Fetal Health Research Centre, University of Manchester. After graduation from the University of Birmingham Medical School in 2000, he commenced clinical training in Obstetrics and Gynaecology. After completing his PhD thesis on placenta dysfunction in preeclampsia at the University of Manchester, he has focussed his research interests around stillbirth and is particularly interested in the role that placental dysfunction plays in this condition. He has also applied metabolomic techniques to the placenta to further understand the nature of placental dysfunction in complex pregnancies. He has published over 70 research papers and supervised 7 postgraduate students. Contact: Maternal and Fetal Health Research Centre, University of Manchester, UK Phone: +44 161 701 0889 Email: [email protected]

Contact: Department of Physiology, Development and Neuroscience, University of Cambridge, England Email: [email protected]


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SPEAKERS BIOGRAPHIES Thierry HEIDMANN Thierry Heidmann is heading a CNRS Research Unit at the Institut Gustave Roussy. His work is devoted to retroelements of higher eukaryotes, with special emphasis on endogenous retroviruses and their impact on physiology and physiopathology. He contributed to the elucidation of the mechanism for their mobility and control, to the characterization of functional elements within mammalian genomes, and to the identification of syncytins, envelope genes from ancestrally captured retroviruses that can be found in eutherian mammals and are involved in syncytiotrophoblast formation and placentation. Contact: UMR 8122 CNRS, Institut Gustave Roussy, Villejuif, France Phone: +33 1 42 11 49 70 Email: [email protected]

Ursula HIDEN I started to study molecular biology in 1996. In 2001, I began working in the field of diabetes in pregnancy with my doctorate in the research laboratory of Prof. Gernot Desoye at the Medical University of Graz. In 2005 I finished my Doctoral Thesis about the In vitro effect of insulin on human placental cells. Since then I had my own research projects and stayed in the department as a PostDoc. My scientific interest deals with the effects of the diabetic environment on placental development and function. Lately, especially the impact of maternal diabetes on the feto-placental vasculature and endothelial function intrigues me. I attended IFPA meetings since 2005 where I had several oral presentations and received twice the New Investigator Award. For the meeting 2011, I co-organized the workshop “Angiogenic signalling and regulation of fetal endothelial function in the human placenta”. Because of my particular interest of the effect of maternal diabetes on the placenta I became member of the Diabetic Pregnancy Study Group (DPSG) from which I received 2013 the Joseph Hoet Research Award. Contact: Department of Obstetrics and Gynecology, Medical University of Graz, Graz Austria Phone: +43 316 385 17842 Email: [email protected]


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SPEAKERS BIOGRAPHIES Maris LAAN Maris Laan is a professor in Human Molecular Genetics. She graduated her PHD in 1997 at the University of Helsinki in Finland. Since 2002 she works at the Institute of Molecular and Cell Biology at the University of Tartu. From 2004 to 2009 she worked as a Research Professor in Biotechnology. and from 2005 to now she works as a Professor in Human Molecular Genetics. She received the Estonian Biocentre Women in Science Award in 2003 and a National Science Award in Molecular Biology and Chemistryin 2010. Her research interests are targeted to human complex traits with the emphasis on reproductive and cardiovascularmetabolic system. Her current research is focused on placental genetics, transcriptomics and epigenetics in successful and complicated pregnancies, and in-depth studies of genes with pleiotropic effects in regulating metabolic traits and reproductive physiology. The research is carried out in close collaboration with Tartu University Hospital Women’s Clinic and Andrology Centre and it has translational potential in reproductive medicine to develop novel non-invasive biomarkers for diagnosis/prognosis of reproductive success. Contact: Faculty of Science and Technology, Institute of Molecular and Cell Biology, University of Tartu, Estonia Email: [email protected]


Marc LECUIT

Marc Lecuit is a physician scientist working on the pathophysiology of human mucosal, maternal-fetal and central nervous system infections. He is Professor of Medicine at the Paris Descartes University and Deputy Head of the Department of Infectious diseases and Tropical Medicine at the Necker-Enfants malades hospital. He is the director of the Biology of Infection Unit at the Institut Pasteur and Inserm. He was trained at the Paris Descartes University, the Denis Diderot University, the Institut Pasteur and in Washington University in St Louis, USA. His research focuses on the molecular mechanisms underlying the species and tissue tropisms of human pathogens. He has made important contributions on the deciphering of the molecular mechanisms underlying the pathophysiology of human listeriosis, and in particular on the crossing of host barriers by Listeria monocytogenes, the etiological agent of this deadly bacterial infection. Contact: Institut Pasteur, Inserm, Paris Descartes University, Necker-Enfants malades University Hospital Phone: + 33 1 40 61 30 29 Email: [email protected]

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SPEAKERS BIOGRAPHIES Nicole LEDOUARIN Scientific patron of the meeting: Prof. Nicole Le Douarin, honorary permanent Secretary of the French Académie des Sciences. Nicole Le Douarin is honorary Professor at the College de France in Paris and former Director of the Institut d’Embryologie Cellulaire et Moléculaire du Collège de France et du CNRS. Nicole Le Douarin understood that a peculiarity of quail cells, that she noticed, could become the basis of a stable, uniquely reliable cell marking technique, allowing the migration and fate of embryonic cells to be followed throughout embryogenesis by the construction of quail-chick chimeras. This approach enabled her to decipher the fate and role of the neural crest in vertebrate development. Nicole Le Douarin’s scientific achievement covers more than 450 articles and several books which made her world famous and unanimously recognized as a major driving force in modern developmental biology. She is the recipient of distinguished international awards such as: Kyoto Prize of Advanced Technology, Jeantet Prize for Medicine, Gold Medal of CNRS. She is a member of many academies including: the French Académie des Sciences, Royal Society (UK), US National Academy and Doctor Honoris Causa of several highly regarded Universities. She is honorary Permanent Secretary of the Académie de Sciences, Paris. Contact: College de France, Paris Email: [email protected]

Richard MILLER

Richard K. Miller, Ph.D. is Professor of Obstetrics/Gynecology, of Pathology and of Environmental Medicine at the University of Rochester, School of Medicine and Dentistry in Rochester, New York. Since 1987, he has been the Director of the PEDECS (Perinatal Environmental and Drug Exposure Consultation Service), which is the New York State Teratogen Information Service. Professor Miller received his undergraduate and graduate training at Dartmouth College and Dartmouth Medical School in Pharmacology and Toxicology. He then pursued a fellowship in Developmental Biology and Teratology at Jefferson Medical College. He has chaired or been a member of committees for many national and international scientific organizations including the National Children’s Study, the US National Toxicology Program, NIH/WHO Indoor Pollution Workshop, TERIS, WHO, NIH, EPA, and FDA, founding secretary of the International Federation of Placental Associations and organizer of the Rochester Trophoblast Conferences from 1980 -2000. In 2013, he received the Teratology Society Distinguished Service Award. Further he received the Bock Prize in Developmental Biology and Child Health. He is currently a member of the Scientific Board and dysmorphologist for the US National Ribavirin Pregnancy Registry. He has been elected a Fellow of the Academy of Toxicological Sciences. His current research involves 1. the vertical transmission of the HIV-1 and the role of anti-HIV therapy, 2. the reproductive toxicity of heavy metals and nanoparticles, and 3. the role of vitamins in normal and abnormal development, especially vitamins A, B12, C and E. He is the lead investigator for a 20 institution study of placental genetic, epigenetic and environmental investigation as part of the NIH - National Children’s Study. Contact: Obstetrics/Gynecology, of Pathology and Environmental Medicine department, University of Rochester, New York Phone: +33 1 58 52 75 25 20 Email: [email protected]


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SPEAKERS BIOGRAPHIES Olivier MOREL Olivier Morel, MD, PhD, Professor of Obstetrics and Gynecology, Chairman of Obstetrics, Fetal Medicine and Gynecology, Academic Hospital of Nancy, Lorraine University, Nancy France. Olivier Morel is a young Professor of Obstetrics and Gynecology. Chairman of OB-Gyn at the Lorraine University since the year 2012, he develops new approaches in the field of placental imaging. His researchs are realized in the IADI laboratory (Adaptative diagnosis and interventional imaging), dedicated to the development of new imaging techniques. In vivo functionnal approaches are developped: 3D Doppler and MRI. This work, focused on utero-placental imaging, is translationnal: from fundamental research in vitro and with animal models to clinical applications. Contact: Obstetrics, Fetal Medicine and Gynecology, Academic Hospital of Nancy, Lorraine University, Nancy France, IADI Inserm u947 Phone: +33 6 88 22 31 40 Email: [email protected]


Guillaume PIDOUX As a part of the Inserm UMR-S-1139, the group’s work, leading by Guillaume Pidoux, addresses a complex biological phenomenon : the cell fusion, which occurs in fertilization, fetal development, skeletal muscle formation, bone homeostasis and tumor progression. Cell fusion and syncytial formation result in the mixing of plasma membrane components and merging of cell content between two or more cells. Currently, the «cell fusion» group is focused on understanding spatiotemporal regulation of intracellular signaling pathways and in particular, how cAMP signaling networks cross-talk with and integrate into the complex web of signaling pathways. In order to perform their research, the group also establishes new tools and technology platforms for in-depth study of these pathways and to promote the development of highly specific pharmaceuticals with minimal side-effects. The ultimate aim is to understand the molecular mechanisms governing cell fusion processes in models such as trophoblasts and cancer cells. Contact: Inserm UMR-S-1139, Paris Phone: +33 1 53 73 96 02 Email: [email protected]

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SPEAKERS BIOGRAPHIES Michel RECORD The common denominator across my career has been to investigate the role of lipidic molecules in cell membrane organization and signaling in relationship with cell functions in inflammation, immunity , and cancer development. As a biochemist my PhD was devoted to analyse the lipid membrane organization of tumor cells and I became interested in the metabolism of ether-linked phospholipids that I investigated during a post-doct in the US (1983-86). Then I moved to the role of enzymes generating lipidic second messengers , in particular the phospholipase D(PLD). During discussions in the team we wondered whether the PLD could be involved in the release of vesicles outside the cell. But which model for that ? At the dawn of the 21rst century I called several people at the Basel Institute for Immunology where had stayed for a sabbatical …and fell into the ”exosome story “. Indeed it turned out rapidly that exosomes were not “classical” vesicles. During the last 10 years I have focused my researches on this exciting topic. (M.R, research director at INSERM, Cancer Research Center of Toulouse, France). Contact: INSERM -UMR 1037, Centre de Recherche en Cancerologie de Toulouse, Toulouse Phone: + 33 5 61 42 46 48 Email: [email protected]

Claire ROBERTS Professor Claire Roberts is a NHMRC Senior Research Fellow (SRFB) and leads the Placental Development Laboratory in the Robinson Institute, University of Adelaide where she has worked since 1995. She is a coleader of the Pregnancy Theme in the Robinson Institute and is a coconvenor of Healthy Development Adelaide, a statewide research organisation focussed on communication of the broad spectrum of reproductive, maternal, child and adolescent health, education and wellbeing to stakeholders and the general public. She has significant expertise in cellular and molecular mechanisms in placental development and function and their causal roles in fetal growth and predisposition to pregnancy complications. Her international leadership in the field is exemplified by the fact that she is the President of the Australian New Zealand Placenta Research Association (ANZPRA) and Treasurer of the International Federation of Placenta Associations (IFPA). Claire Roberts takes a bench to bedside approach to her research programme with a strong track record in pregnancy in a variety of human pregnancy cohorts, animal models and in vitro experimentation. Claire leads research with a particular focus on delineating geneenvironment interactions, hence epigenetic state, before and during pregnancy that impact maternal and infant health. She is developing screening tools for use in early pregnancy to predict which couples are at risk of common and potentially life threatening pregnancy complications. Contact: Placental Development Laboratory, Robinson Institute, University of Adelaide, Australia Email: [email protected]


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SPEAKERS BIOGRAPHIES Yoel SADOVSKY Yoel Sadovsky received his MD degree from the Hebrew UniversityHadassah Medical School in Jerusalem in 1986, followed by OBGYN residency at Washington University in St. Louis and maternalfetal medicine and postdoctoral research fellowships at UCSF. He then returned to Washington University, where he was appointed tenured professor of OBGYN, and Cell Biology and Physiology. Dr. Sadovsky served as Director of the Division of Maternal-Fetal Medicine from 1999-2007. In 2007, he assumed directorship of Magee-Womens Research Institute at the University of Pittsburgh, and was appointed Vice Chair, Department of Obstetrics, Gynecology and Reproductive Sciences. Building on his clinical and scientific expertise in perinatal medicine, Dr. Sadovsky integrates high-throughput tools to decipher trophoblast function and adaption to cellular injury, thus illuminating key mechanisms underlying fetal growth restriction and its consequences. A primary focus is the function of trophoblast-specific microRNAs that govern placental response to hypoxia, resistance to viruses, and trafficking of microRNAs between the fetal, placental, and maternal compartments. Dr. Sadovsky also interrogates trophoblast utilization and trafficking of lipids that are essential for fetal development. Dr. Sadovsky’s laboratory is funded via a P01 and several R01 NIH grants, and his investigation has resulted in the publication of more than 120 peer-reviewed scientific articles and 20 book chapters and invited publications, and his selection for the Society for Gynecologic Editor for Investigation’s (SGI) President’s Achievement Award in 2004. Dr. Sadovsky has served on several National Institute of Child Health and Human Development (NICHD) study sections and chaired the NICHD Genomic and Proteomic Network for Preterm Birth Research steering committee. He is currently a member of the NICHD Board of Scientific Counselors and the March of Dimes Scientific Council. He also serves as an Editor for the journal Placenta. Last year, Dr. Sadovsky was elected as a member of the Institute of Medicine (IOM).

Henning SCHNEIDER

Dr. Henning Schneider is Emeritus Professor of Obstetrics & Gynecology at the University of Berne. He received his MD 1965 from the University of Kiel, Germany. He did his scientific postdoctoral training in the years 1968 till 1971 with Prof. M. Panigel at an INSERM Unit in Paris and with Prof. J. Dancis at New York University in New York. At NYU he also did a residency in Obstetrics & Gynecology followed by a fellowship in Maternal Fetal Medicine. He is board certified in both. After 2 years in Marburg, Germany he moved to Zurich, Switzerland in 1978. In 1987 he was appointed professor and chair in Obstetrics & Gynecology at the University of Berne, Switzerland. Till 2002 he was director of the Maternity Hospital of the Kanton of Berne. In 2002 this institution moved to a new building and became the maternity unit of the Inselspital Berne. In 2005 he retired and became Emeritus Professor of the University Berne. His research focussed on the physiology and pathology of the placenta and its role in pregnancy related disorders such as preeclampsia and preterm delivery. He is widely recognized as an expert in the method of ex vivo dual perfusion of human placental tissue and most of his basic research is based on the development of this method and its various applications. As representative of the European Placenta Group (EPG) he was directly involved in the foundation of IFPA and after Peter Kaufmann he acted as the second president of this organization from 1997 till 2000. In 2008 together with Stefan Hansson he organized the first European Placenta Perfusion Workshop at the University of Lund, Sweden. In the mean time there have been 6 of these workshops in various places in Europe. The next one is planned for June of 2014 in Jena, Germany. Contact: University of Berne – Inselspital Phone: + 41 319 617 430 Email: [email protected]

Contact: Magee-Womens Research Institute, Pittsburgh, USA Phone: +1 41 26 41 26 75 Email: [email protected]


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SPEAKERS BIOGRAPHIES Colin SIBLEY Colin Sibley obtained a first class honours degree in Biochemistry and Physiology (1976) and his PhD (1980) from the University of London. In 1982, Colin became Wellcome Trust Lecturer in Child Health and Physiology at the University of Manchester and the following year was appointed to a substantive University Lectureship. He spent a year on sabbatical in 1989 as a Visiting Scientist in the Department of Pharmacology at Washington University St Louis, working with Professor Irv Boime. He became Senior Lecturer in 1990, Reader in 1994 and was appointed to a personal Chair in 1997.Colin is currently Professor of Child Health and Physiology and Director of the Tommy’s [Lets Talk Baby] Charity, Maternal and Fetal Health Research Centre (MFHRC) in Manchester. He has published over 170 peer reviewed papers, currently holds several major grants from the Medical Research Council, The Wellcome Trust, Department of Health and other AMRC charities and leads his own group of around 20 researchers, as well as the 60 plus scientists and clinician scientists, technical and clerical staff of the MFHRC; it is the largest pregnancy research group in Europe. In 2009 Colin was appointed Head of the Research and Innovation Division at Central Manchester University Hospitals NHS Foundation Trust. In this role he is responsible for research and innovation strategy in one of the largest hospitals in the UK.

Erica WATSON Erica Watson, Centre for Trophoblast Research, Dept of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK. Erica Watson is currently a Lecturer in Reproductive Biology at the Department of Physiology, Development and Neuroscience in the University of Cambridge. Her lab studies the long-term generational effects of defective folic acid (also known as folate) metabolism during placental and fetal development using molecular and epigenetic techniques. Erica received her Bachelors degree in Cellular and Molecular Biology at the University of Calgary (Canada) and gained her PhD in the laboratory of Professor Jay Cross (Calgary) in 2008, where she investigated how changes in cell architecture and organization affect trophoblast cell differentiation and early placental development in mice. In 2009, Erica was awarded a Next Generation Fellowship from the Centre for Trophoblast Research at the University of Cambridge where she began her independent research programme examining the transgenerational transmission of embryonic and placental phenotypes caused by abnormal folate metabolism. Contact: Department of Physiology, Development and Neuroscience in the University of Cambridge, England Email: [email protected]

Contact: University of Manchester, Manchester Phone: +44 161 276 6484 Email: [email protected]


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PROGRAM - Tuesday 9th September 2014 09:00

IFPA Executive meeting (by invitation)

14:00

Welcome

15:30

Welcome address IFPA Meeting 2014 Chairs: Danièle EVAIN -BRION IFPA Meeting 2014 Conference Chair (France) Nick ILLSLEY President of IFPA (USA)

Audiovisual sequence « I love Paris » Danièle and Christian BRION 16:00 Scientific sessions Opening Nicole LEDOUARIN French Academy of Sciences 16:20

Plenary session 1 Chairs: Anthony CARTER (Denmark) and Isabella CANIGGIA (Canada)

Role of the “captured” retroviral envelope genes syncytins in placentation Thierry HEIDMANN (CNRS, Institut Gustave Roussy, France)

Listeria monocytogenes crossing the placental barrier Marc LECUIT (Inserm, Université Paris Descartes, Institut Pasteur, France)

17:25

End of the day

18:30

Opening Reception at Town Hall Loke and NIH awards

23:00

End of the day


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PROGRAM - Wednesday 10th September 2014 07:30

Welcome

08:00

Awards committee

09:00

Plenary session 2: Placental hormones Chairs: Carlos SALOMON (Brisbane, Australia) and Hannele LAIVUORI (Finland)

Endocrine control of intrauterine development Abby FOWDEN (University of Cambridge, United Kingdom)

Profile of placental gene expression and pregnancy outcome Maris LAAN (University of Tartu, Estonia)

Everything you always wanted to know about hCG Thierry FOURNIER (Inserm, Université Paris Descartes, France)

10:30

Coffee break

11:00

New Investigators - Session 1 Sponsored by the University Paris Descartes Chairs: Estela BEVILACQUA (Brazil) and Mahmoud AHMED (USA)

Expression of the β-isoform of the Thromboxane A2 receptor regulates maternal and fetal derived characteristics of pre-eclampsia Katie POWELL (Kolling Institute of Medical Research, Sydney, Australia) Impact of the Transcription Factor Nrf2 on Murine Placental Development Nisreen KWEIDER (RWTH Aachen University, Aachen, Germany)

Altered placental function in the tryptophan hydroxylase 1 knock-out mouse - From fetal development in utero to erythropoiesis in post-natal life Kathy DEROY (Institut Armand Frappier, INRS, Laval, Quebec, Canada) 3D Surface Reconstruction of Human Terminal Villi and the Fetal Capillary Bed Romina PLITMAN MAYO (University of Cambridge, Cambridge, UK)

Large Cohort Microarray Analysis Reveals Multiple Distinct Subclasses of Preeclampsia Katherine LEAVEY (University of Toronto, Toronto, Canada) 12:15

The Elsevier Trophoblast Research Award Lecture Chairs: Alexandra GELLHAUS (Germany) and Theresa POWELL (USA) Underlying mechanisms directing ADAM12-mediated trophoblast invasion Mahroo AGHABABAEI (University of British Columbia, Vancouver, Canada)

12:40

Buffet Lunch

13:45

Workshops (parallel sessions)

1. Advances in placental imaging 2. Biomarkers of pregnancy pathologies 3. Animal models to study pregnancy pathologies

16:15

New Investigator organized session Chair: Sally COLLINS (Oxford, UK) The ECR Balloon Debate: «Three experts each try to persuade you that their subject is the most vital in the field of placental research» Graham BURTON (Cambridge), Brian COX (Toronto) and Alex HEAZELL (Manchester) debating

17:00

Regional Business meetings (open to everyone)

17:30

Poster session 1 Around Champagne

19:30

End of the day


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PROGRAM - Thursday 11th September 2014 07:30

Welcome

08:00

Placenta/Trophoblast Research Editorial board

09:00 10:30

Plenary session 3: Focus on trophoblast cell biology Chairs: John APLIN (UK) and Nadia ALFAIDI (France) Intercellular communication by the exosomes in placenta Michel RECORD (INSERM, Université de Toulouse, France) MiRNA nano-packages for maternal-placental-fetal communication Yoel SADOVSKY (University of Pittsburg, USA) Annexin -A5 and membrane repair in the placenta Alain BRISSON (Université de Bordeaux, France) Coffee break

11:00 New Investigators - Session 2 Sponsored by the University Paris Descartes Chairs: Graham BURTON (UK) and Paola CASANELLO (Chile) Targeted delivery of Insulin-like Growth Factor-II to the placenta using homing peptide-decorated liposomes increases placental weight Anna KING (University of Manchester, Manchester, UK) Role of miR-218 in trophoblast cell migration, invasion and spiral artery remodelling Jelena BRKIC (York University, Toronto, Canada) Modeling defects in trophoblast differentiation using Trisomy 21-affected human pluripotent stem cells Mariko HORII (University of California, San Diego, La Jolla, USA) Notch2 controls differentiation-dependent hormone expression in human decidual stromal cells of early pregnancy Gerlinde OTTI (Medical University of Vienna, Vienna, Austria) New insights into the mechanism of PPARγ regulation of trophoblast invasion and placental vascularisation Vanessa GARNIER (CEA Grenoble, Grenoble, Grenoble, France) 12:15

Gabor Than Award Chairs: Peter Mark (Australia) and Yoshiki KUDO (Japan) Identification of Placental Failure – The Key to Saving Babies’ Lives? Alexander HEAZELL (Manchester Academic Health science Center, UK)

12:45

Buffet Lunch

13:45

Workshops (parallel sessions) 4. Genetics and epigenetics 5. Placenta and stillbirth and IUGR 6. New approaches to study human placenta exposure to xenobiotics

16:15 16:45

IFPA Business Meeting

17:30

Poster session 2 Wine and cheese

19:30

End of the day

New investigator organized session Chair: Carlos SALOMON (Brisbane, Australia) Career advise session Greg Rice (Herston, Australia) and Annetine Staff (Oslo, Norway)


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PROGRAM - Friday 12th September 2014 07:30

Welcome

09:00

Plenary session 4: EPG Mid-career investigators Sponsored by Inserm Chairs: Martin KNÖFLER (Austria) and Padma MURTHI (Australia)

Cell fusion in space and time Guillaume PIDOUX (INSERM, Université Paris Descartes, France)

Placental tryptophan metabolism: a new pathway for the fetal programming of adult mental disease Alexandre BONNIN (University of Southern California, Los-Angeles, USA)

The effect of maternal diabetes on feto-placental endothelial cells Ursula HIDEN (Medical University of Graz, Austria)

11:00

How the placenta reveals the sins of your grandparents Erica WATSON (University of Cambridge, United Kingdom)

11:30

NIH Sponsored lecture Chairs: Leslie MYATT (USA) and Pascale CHAVATTE PALMER (France)

Human stem cells from single blastomeres reveal pathways of embryonic or trophoblast fate specification Susan FISHER (University of California, UCSF, USA)

12:30

Interest of large cohorts Chairs: Annetine STAFF (Norway) and Jan Japp ERWICH (Netherlands)

Coffee break

Human placental study of genetics/genomics, environmental contaminant and morphology assessments from 10 US Sites Methods and results from the US national children’s study Richard MILLER (University of Rochester, USA) 12:45 How big is big enough? Population differences in pregnancy outcome Claire ROBERTS (University of Adelaide, Australia) 13:00

13:00

Final Poster judging awards committee Lunch


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PROGRAM - Friday 12th September 2014 14:00

Plenary session 5 The fetus IUGR and the placenta Chairs: Stefan HANSSON (Sweden) and Marie JIRKOVSKA (Czech Republic)

Utero-placental vascularization: new imaging techniques Olivier MOREL (Université de Lorraine, Nancy, France)

Exchange across the placenta in fetal growth restriction and stillbirth Colin SIBLEY (University of Manchester, United Kingdom)

15:00

Placental destiny through ages and culture Chairs: Cathy VAILLANCOURT (Canada) and Alessandro ROLFO (Italy)

Sylvie EPELBOIN (Hôpital Bichat-Claude Bernard, Paris, France)

15:30

Senior IFPA Award in placentology Chairs: Richard MILLER (USA) and Nick ILLSLEY(USA)

Ex vivo dual perfusion of a human placental cotelydon – modifications of access to the intervillous space Henning SCHNEIDER (University of Bern, Switzerland) 16:30

End of the day

19:00

Gala dinner Cruise on the Seine (on reservation)


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BUSINESS MEETING SCHEDULE Tuesday 9th September 2014 09:00 - 13:00 IFPA Executive meeting (by invitation) Thesis Room 13:15 - 15:15 IFPA Executive lunch (by invitation) Restaurant « Le Procope »

Wednesday 10th September 2014 08:00 - 09:00 Awards committee Thesis Room

Thursday 11th September 2014 08:00 - 09:00 Placenta/Trophoblast Research Editorial board Thesis Room

Friday 12th September 2014 13:00 - 14:00 Final Poster judging comittee Thesis Room


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WORKSHOPS - WEDNESDAY 10TH SEPTEMBER 2014 Parallel session - 13:45 - 16:15 Workshop 1: Advances in placental imaging (Roussy Amphi) Organizers: Vassilis TSATSARIS (AP-HP– Université Paris Descartes, France) Sally COLLINS (John Radcliff hospital Oxford, UK) Mickael TANTER (Institut Langevin, ESCPI Paris Tech, France) Our 2.5 hr workshop will explore the major advances in placental Imaging over the last years. There will be a series of short talks (20 minutes including question time) interspersed with discussion and concluding with a Q&A session where the audience will be encouraged to question our expert panel on any aspect of placental Imaging. Confirmed speakers and preliminary titles/order are as follows: Brief introduction Interest and predictive value of placental 3D doppler ultrasonography in the first trimester of pregnancy. Pr Olivier MOREL (Université de Lorraine, France) Influence of Doppler Settings on VOCAL indices Dr Sally COLLINS (John Radcliff hospital Oxford, UK) BOLD MRI and feto-placental oxygenation Pr Laurent SALOMON (AP-HP, Université Paris Descartes, France) Ultrafast Doppler. A new approach for Doppler Imaging Dr Mickael TANTER (Institut Langevin, ESCPI Paris Tech, France) Question & Answer panel discussion Brief concluding remarks

POSTER SESSION 1 - Wednesday 10th September 2014

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WORKSHOPS - WEDNESDAY 10TH SEPTEMBER 2014 Parallel session - 13:45 - 16:15 Workshop 2: Biomarkers of pregnancy pathologies (Farabeuf Amphi) Organizers: Jean Guibourdenche (AP-HP , INSERM – Université Paris Descartes, France) Claire Roberts (Robinson Research Institute, University of Adelaide, Australia) Finding new markers of human diseases is an important aim of both basic science and clinical research. In pregnant women, these markers can be clinical or sonographic markers or biological markers, also called biomarkers. However, different approaches can be used to identify and to validate emerging biomarkers. This depends mainly on the physiology and the characteristics of these biomarkers (nature, secretion, pharmacokinetics), the concerned disease and the aim of research (ie screening or diagnosis of a frequent or a rare disease). In this workshop the different speakers will share their own experience in biomarkers of pregnancy pathologies from placental origin. Claire Roberts has been working to identify clinical, lifestyle and genetic markers that predict pregnancy outcome for a decade. Jean Guibourdenche is involved for many years in the maternal screening of fetal Trisomy 21 and the characterisation of the trisomic T21 trophoblast. Annetine Staff is a leading European researcher validating angiogenic biomarkers of preeclampsia across different pregnancy cohorts in the global CoLab network.Vincent Sapin and Denis Gallot have developed different strategies for new biomarkers of premature rupture of membranes. Carlos Salomon is working on the clinical interest of placental-derived exosomes. They will discuss various steps of the process from the methodology used to identify new biomarkers, the constitution of the biobanks and cohorts, to the validation of this marker and its clinical value in a daily practice. 13:45 - 14:00 Introduction: curriculum vitae of the ideal biomarker Pr Jean Guibourdenche, AP-HP , INSERM – Université Paris Descartes, France 13:55 - 14:10 Australia: placental-derived exosomes as potential biomarkers of placental function during pregnancy Dr Carlos Salomon, Centre for Clinical Research, University of Queensland 14:20 - 14:35 From clinics to proteomics : PROM biomarkers identification Pr Denis Gallot, CHU Clermont Ferrand - Université d’Auvergne, France 14:45 - 15:00 Gene environment interactions and outcomes in Australian pregnant women Pr Claire Roberts , Robinson Institute, University of Adelaide, Australia 15:10 - 15:25 Collaboration across pregnancy cohorts on placenta-derived biomarkers, the Global CoLab experience Pr Anne Cathrine Staff, University of Oslo, Norway 15:35 - 15:45 From the mothers to their preterm neonates, the french cohort Perinatcollection (PremUP foundation) Pr Jean Guibourdenche, AP-HP , INSERM – Université Paris Descartes, France 15:50 - 16:05 Conclusion: features of an ideal cohort Pr Claire Roberts , Robinson Research Institute, University of Adelaide, Australia


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WORKSHOPS - WEDNESDAY 10TH SEPTEMBER 2014 Parallel session - 13:45 - 16:15 Workshop 3: Animal models to study pregnancy pathologies (Pasquier Amphi) Organizers: Anne TARRADE (INRA, Jouy en Josas) Ted GOLOS (University of Wisconsin, Madison) Human placental models offer the advantage of direct observation of human trophoblast biology, and mouse models offer the ability to genetically modify specific loci for direct mechanistic study. However other models offer advantages of size, accessibility of fetal physiology, or comparative insights for providing a broad understanding of placental function and fetal growth and development. The goal of this workshop is to make placentologists aware of opportunities for research with other systems beside human or mouse models. In this workshop placental researchers will present the advantages and disadvantages of their models of choice. A short presentation has been selected from the submitted abstracts to add the most late-breaking research. There will be ample time for discussion of strengths and opportunities to extend current placental research to additional animal models. 13:45 - 14:00 Rabbit as model to study feto-placental programming Dr Anne TARRADE, INRA, Jouy-en-Josas 14:00 - 14:15 New World species models of placental biology Dr Phelipe FAVARON, University of Sao Paolo, Brazil 14:15 - 14:30 Making a fetus grow: lessons from a sheep paradigm Dr Jacqueline WALLACE, University of Aberdeen, UK 14:30 - 14:45 Experimental value of bovine placenta: pros and cons Dr Christiane PFARRER, University of Hanover, Germany 14:45 - 15:00 Porcine models of nutritional challenges during pregnancy Dr Antonio GONZALEZ-BULNES, INIA, Spain 15:00 - 15:10 Short presentation: Placenta in equine models of fetal programming Pauline PEUGNET, INRA/Jouy-en-Josas 15:10 - 15:25 In vivo and in vitro studies of placental nutrient transport in the baboon Dr Thomas JANSSON, University of Texas-San Antonio 15:25 - 15:40 Genomic editing: opportunities for all in modeling placental pathologies Dr Ted GOLOS, University of Wisconsin 15:40 - 16:15 General discussion and formulation of summary: strengths, weaknesses, areas for needed work, future prospects


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WORKSHOPS - THURSDAY 11TH SEPTEMBER 2014 Parallel session - 13:45 - 16:15 Workshop 4: Placental genetics and epigenetics (Pasquier Amphi) Organizers: Richard SAFFERY (MCRI, University of Melbourne, Australia), Daniel VAIMAN (INSERM, University Paris Descartes, France) Our 2.5 hr workshop will explore the varying roles of genetic and epigenetic variation in regulating placental function. There will be a series of short talks (20 minutes including question time) interspersed with discussion and concluding with a Q&A session where the audience will be encouraged to question our expert panel on any aspect of placental epi(genetics). Confirmed speakers and preliminary titles/order are as follows: Brief introduction Chromosomal abnormalities of the placenta and their impact on placental function and fetal outcome Pr Wendy ROBINSON, University of British Columbia, Canada Pathway-guided genome-wide meta-ananalysis for the identification of pre-eclampsia genes’ Pr Cees OUDEJANS, VU University Medical Center, The Netherlands Identification of novel imprinted genes in the human placenta Dr Sandrine BARBAUX, Université Paris Descartes, Paris, France Imprinted genes in the placenta: just how many are there? Dr David MONK, Bellvitge insitute for Biomedical Research, Spain Genome-scale methylation analysis reveals common methylation variants associated with trophoblast differentiation, hypoxia and pre eclampsia Dr Boris NOVAKOVIC, University of Melbourne, Australia Beyond DNA methylation: ChiP:Seq analysis of placental samples as part of the National Childrens Study Dr Melissa SUTER, Baylor College of Medicine, USA Question & Answer panel discussion Brief concluding remarks

POSTER SESSION 2 – Thursday 11th September 2014

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WORKSHOPS - THURSDAY 11TH SEPTEMBER 2014 Parallel session - 13:45 - 16:15 Workshop 5: The placenta and stillbirth and fetal growth retardation (Farabeuf Amphi) This workshop will review the importance of placental examination following stillbirth and complicated pregnancies. It will cover important issues including standardisation of sampling, definitions of diagnoses and how scientific investigations can help understand the nature of lesions seen in stillbirth and fetal growth restriction. We will discuss a scheme for international consensus on examination of the placenta in stillbirth and complicated pregnancies. 13:45 - 13:50 Introduction 13:50 - 14:05 Systematic Review of Placental Pathology Dr Alexander HEAZELL (Manchester Academic Health Science Center, UK) 14:05 - 14:25 Placental Pathology – Findings in Singleton Stillbirths Pr Halit PINAR (Providence, USA) 14:25 - 14:35 Standardizing Placenta Processing Procedures Across A Multi-Site Network Through the Creation of a Certification and Quality Control Program 14:35 - 14:55 Classification of Stillbirths - Insight from the TULIP classification Pr Jan-Jaap ERWICH (Haren, The Netherlands) 14:55 - 15:10 In vitro models to explore placental findings in stillbirth Pf Mana PARAST (San Diego, USA) 15:10 - 15:20 Decreased placental weight centile and increased birthweight:placental weight ratios in stillbirths suggests placental insufficiency even in stillbirths of “unknown” cause Dr Stephanie WORTON (Manchester, UK) 15:20 - 16:00 : Group discussions What do we need in place to move forward? 16:00 - 16:15 : Feedback from groups and concluding remarks


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WORKSHOPS - THURSDAY 11TH SEPTEMBER 2014 Parallel session - 13:45 - 16:15 Workshop 6: New approaches to study human placental exposure to xenobiotics (Roussy Amphi) Organizers: Sophie GIL (Université Paris Descartes, France) and Rohan LEWIS (University of Southampton, UK) Exposure to xenobiotics during pregnancy is inevitable. The human placenta is considered as a selective barrier to protect the fetus against xenobiotics. With respect to drugs, assessing their transport across the human placenta has always been of vital importance to ensure the safety of drugs during pregnancy. With respect to pollutants, they are everywhere in the environment and a large number of these environmental contaminants cross the human placenta. Determination and quantification of these xenobiotics have always been a challenge. Moreover, they are likely to act not only directly on the fetus but also on the placenta itself which may affect its ability to support the pregnancy. The purpose of this workshop is to present up to date information on the different approaches to studying xenobiotics assays, human placental transfer, xenobiotic metabolism and related mechanisms such as transporter functions. Different studies, which take into account in vivo and in vitro investigations, as well as the ex vivo perfusion method will be introduced. At the end we would like to have a 30 minutes discussion with 2-3 illustrations and finally a summary conclusion to explore where the next challenges are, with a few sentences from each speaker. 13:45 - 14:05 Biometal measurements on the US National Children’s Study (NCS) placenta samples Dr T.A. DARRAH (USA) 14:05 - 14:25 New mass spectrometric approaches to investigate placental exposure to environmental pollutants Pr O. LAPRÉVOTE, France 14:25 - 14:45 The placental perfusion model; advantages, disadvantages, present and future Dr R.M. Lewis, UK 14:45 - 15:05 Transfer, localization and placental metabolism of benzo(a)pyrene Pr S. GIL, France 15:05 - 15:25 A human cell-based co-culture model for fundamental and applied studies of human fetoplacental steroidogenesis and interference by xenobiotics Dr C. VAILLANCOURT, Canada 15:30 - 16:05: General discussion with 2-3 illustrations 16:05 - 16:15: Conclusion and formulation of summary 16:00 - 16:15: Feedback from groups and concluding remarks


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IFPA AWARDS New Investigator Oral Award Presentations will be judged by a panel and will be eligible for The Elsevier Placenta New Investigator Award Investigator Award The award “acknowledges the best oral presentation by a new investigator in the field of placentology in all its aspects, including the relationship with fetus and mother” and consists of 1000 Euros and free one-year access to Elsevier Science Direct. The award winner will be announced at the Gala Dinner on Saturday, September 14. New Investigator Poster Award Presentations will be judged by a panel for the Elsevier Trophoblast Research Award, which “acknowledges the best poster presentation by a new investigator in the field of placentology in all its aspects, including the relationship with fetus and mother” and comprises $1500 USD, an invitation to present your work at the next year’s IFPA meeting and free one-year access to Elsevier Science Direct. The 10 invited finalists will be judged at 8 am on Friday, September 12 in a designated area of the Conference Centre lobby. The finalist names will be posted as soon as possible after the second poster session concludes. The award winner will be announced at the Gala Dinner on Friday September 12. Y.W. Loke New Investigator Travel Awards (annual award) Support for New Investigators in Placentology to attend IFPA meetings. New investigators are defined as students or researchers in full-time training or researchers who are within three years of their senior degree (e.g. Ph.D., M.D.).The awards are based on a review of abstracts submitted for an IFPA-designated meeting.

Gábor Than Award (awarded every other year in even years 2010, 2012, 2014 etc.) The “Gábor Than Award” in placentology acknowledges outstanding contributions to the field of placentology in all its aspects, including the relationship with fetus and mother to early career investigators who are normally within 10 years of their terminal degree. Award: The IFPA Gábor Than Award consists of US$2000 plus accomodation and registration for the next meeting and a bronze medal. The awardee will be invited to present a lecture during a plenary session of the same IFPAdesignated meeting. The lecture will be published in «Trophoblast Research» following normal peer review procedures. IFPA Senior Award in Placentology (awarded every year) The «IFPA Senior Award in Placentology» is intended to recognise the work of established senior scientists/ clinicians who have led placental research groups for a substantial period of time and have made a significant contribution to our understanding of placental and reproductive functions in general. Awardees will be able to demonstrate a sustained commitment to the development of younger placental researchers and to the placental/ reproductive research community in general. As a guide to nominators, applicants with 20 years or more experience might be appropriate Award: The IFPA Senior Award represents the highest distinction of the international placental research community. There will be no monetary prize associated with the Award. However, up to $1500 will be reimbursed towards economy class airfare. The awardee will be invited to present a lecture during a plenary session of the same IFPA-designated meeting. The lecture will be published in «Trophoblast Research» following normal peer review procedures.

National Institutes of Health New Investigator Travel Awards These travel awards are to enable US-based new investigators in any aspect of placental research to attend the annual meetings of IFPA. New investigators are defined as students or researchers in full-time training or researchers who are within three years of their senior degree (e.g. Ph.D., M.D.). The awards are based on a review of abstracts submitted for an IFPA-designated meeting.


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NEW INVESTIGATOR TRAVEL AWARDS 2014 - Tuesday 9th September 2014 Town Hall Y.W. Loke New Investigator Travel Awards Anushka AJITH, South Africa

Kaoru NIIMI, Japan

Rossella BARRILE, Italy

Gerlinde OTTI, Austria

Samantha BENTON, Canada

Eszter PAPP, Canada

Victoria BILLS, United Kingdom

Maria PERES, Brazil

Natalie BINDER, Australia

Pierrette PERIMENIS, France

Jelena BRKIC, Canada

Pauline PEUGNET, France

Hugo CREETH, United Kingdom

Romina PLITMAN-MAYO, United Kingdom

Kathy DEROY, Canada

Joanna RAKOCZY, Australia

Francisca DIAZ, Austria

Maria RAVN-NIELSEN, Danemark

Vanessa GARNIER, France

Lewis RENSHALL, United Kingdom

Christine HENKE, Germany

Leyla SATI, Turkey

Anna KING, United Kingdom

Owen STOCK, Australia

Bernardo KRAUSE, Chili

Ellen Marie STRøM-ROUM, Norway

Nisreen KWEIDER, Germany

Mancy TONG, New Zealand

Laetitia LAURENT, Canada

Takafumi USHIDA, Japan

Katherine LEAVEY, Canada

Allerdien VISSER, Netherlands

Edouard LECARPENTIER, France

Amy WINSHIP, Australia

Chao LIU, China A Inkeri LOKKI, Finlande Kathy POWELL, Australia Masahito MIZUUCHI, United Kingdom Hannah MORGAN, United Kingdom Tina NGUYEN, Canada


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NEW INVESTIGATOR TRAVEL AWARDS 2014 - Tuesday 9th September 2014 Town Hall National Institutes of Health New Investigator Travel Award Sonia DA SILVA-ARNOLD, USA Alma DZAFIC, USA Paula DIAZ, USA Mariko HORII, USA Nen HUYNH, USA Khaled OMAR, USA Priyadarshini PANTHAM, USA


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GENERAL INFORMATION CONFERENCE VENUE The IFPA – EPG conference will be held in the historical building of « Le Refectoire des Cordeliers » 15 rue de l’Ecole de Médecine 75006 Paris

CORDELIERS’ HISTORY During the XIII century, the monument was only big fields of gravepine. Louis IX decided to offer these fields to monks called « Les Cordeliers » because of the belt worn to their dress. Between 1234 and 1571, they built a monastery composed by a theology school, two cloisters, gardens, a big church and an important refectory (site of poster exhibition) which is the last building existing of this historic monument. Before the revolution the monks rented rooms to artists or societies for their work. In 1785, « Les Cordeliers » hosted Edme Erniquet who was a famous town-planner and drawn the famous Paris plan corresponding to this period. In 1789, the monument was ceased by the government. The refectory hosted also, « le club des cordeliers »; which was a popular group involved in the French revolution.

They organized meetings in these rooms and debated about lot of subjects but principally about human rights. They imagined the French motto « Liberté, Egalité, Fraternité » in 1791 and were also involved in the protests of the Champ de Mars during the same year. After the revolution, approximately in 1795, the government decided to create the Medicine School in these buildings. In the 1975 the refectory section (the last one) was classified as an historical monument. Today, Les Cordeliers cater 32700 students (10900 in medicine and 21800 in sciences and engineering.


33

MAP LES CORDELIERS 21 rue de l’Ecole de Médecine 75006 Paris

2

4 1

5 3

2 1


1

Farabeuf Amphi

4

Thesis room (RDC)

2

Pasquier Amphi (RDC)

5

Club room

3

Roussy Amphi Level 1

1

Entrance & Welcome Desk

2

Refectory Poster exhibition

3

Room Marie-Curie Lunch-room

< Métro direction

3

34

GENERAL INFORMATION HOW TO GET THERE? By Subway:

You can reach Les Cordeliers using . The closest station is Odéon.

and

Exit: Rue de l’école de Médecine

By Bus:

The lines 63, 70, 86 or 96 take you to Odéon/ Cluny (2€)

Ticket price: 1,70€

By RER:

-

Saint-Michel-Notre Dame station is the closest one at 5 minutes walking from Les Cordeliers

Ticket price: same as a ticket metro inside Paris (3,95€ outside Paris). Exit: Musée du Moyen-Age

OUR ADVICE: Some Smartphone applications could be useful during your trip in Paris: RATP Application: shows you the best way to take. Offline Applications: Maps and guide Paris offline

FROM ROISSY CHARLES DE GAULLE TO « LES CORDELIERS » By RER :

from Roissy you can take the which will bring you to Saint-Michel-Notre Dame station (Musée du Moyen-Age exit)

Shuttle:

By Taxi:

Duration: approximately 40 min (depends on the traffic) Price: between 50 and 60 euros

Air France buses from the airport to the Montparnasse train station. A bus will be available each thirty minutes from 6 am to 10 pm Arrived at the Montparnasse station, take (Porte de Clignancourt direction) and stop at the Odéon station

FROM ORLY TO « LES CORDELIERS » The less expensive way is to take a Orlybus (7,50€) going to Denfert Rochereau and after take (Porte de Clignancourt direction) and stop at Odéon station

By taxi:

Duration: approximately 30 min

Price: between 30 and 40 euros


35

GENERAL INFORMATION TRANSPORTATION PASS The RATP propose passes in order for tourists. If you want to visit Paris during your stay, the best is to choose the « Paris visite » pass because you have an unlimited acces to all transportation access (subway, bus, RER etc.).

Zone 1 to 3

Zone 1 to 5

1 day: 10,85€ 5 days: 34,70€

1 day: 22,85€ 5 days: 59,50€

SUBWAY MAP


36

GENERAL INFORMATION INTERNET ACCESS Free access to the WIFI network. The login and password will be written on your badges

BREAKS AND LUNCHES Lunch breaks time: 1 hour Wednesday: 12.40 am Thursday: 12.45 am Friday: 1 pm Lunch bag will be provided

PARCS

Jardin Médiéval (Cluny)

Some beautiful parcs are close to « Les Cordeliers ». It could be the occasion to visit in order to relax during lunch break. The access to these parcs is easy: Jardin Médiéval: 5-minute walk Jardin du Luxembourg: 10-minute walk Square Paul Langevin: 10-minute walk Square André Lefèvre: 5-minute walk Les Arènes de Lutèce: 20-minute walk

Jardin du Luxembourg


37

PARCS CLOSE TO LES CORDELIERS

Jardin du Luxembourg: rue de Médicis / rue de Vaugirard - 75006 PARIS Square André Lefèvre: 2, rue de la Parcheminerie - 75005 PARIS Jardin Médiéval: 24 rue du Sommerard - 75005 PARIS Square Paul Langevin: between rue des Ecoles and rue de la Monge - 75005 PARIS


38

SOCIAL PROGRAM WELCOME RECEPTION

THE TOWN HALL

It is with a great pleasure that the IFPA congress organizes its welcome reception in one of the most important buildings of Paris: The Paris Town Hall Tuesday September 9th, 2014 Time 6.30 pm A form of ID will be required.

Its history began in 1357 when Etienne Marcel (provost of the merchants = mayor at this period) of Paris, bought the so-called « maison aux pilliers » which will become the building that you know today. Ever since 1357, the administration of Paris has been located on this place: where the Town Hall stands today.

HOW TO GET THERE Hôtel de Ville de Paris, Place de l’Hôtel de Ville, 3, rue de Lobeau - 75004 Paris Recommanded: By walking: approximately 15 minutes Very scenic way.

It is in 1533 that Paris decide to build a real Town Hall under the supervision of King Francis I in order to reflect the greatness of the city. Two architects were hired to build this monument of exception: Dominique de Cortone (Italian), and Pierre Chambiges (French). The house of pillars was removed in a building with the Renaissance spirit which was at the same time, tall, spacious, full of light and refined. Building work finished in 1628 during the reign of Louis XIII. The Historical building has seen lot of events since 1533 as the French revolution or the Prussian contest which resulted to the blaze of the buiilding. Its reconstruction lasted 19 years and was directed by two architects: Théodore Ballu and Edouard Deperthes, who won the public competition for the building’s reconstruction. Information: Lot of statues are inlayed its walls. These statues represent famous french characters as Voltaire, Molière or Lavoisier

Other ways : Metro: take from Odéon to Châtelet (Porte de clignancourt direction) and from Châtelet to Hôtel de ville (Château de Vincennes direction) – 10 min Bus: from Les Cordeliers, walk to Odéon station and take to Chatelet Station and walk to the Hôtel de Ville -10 min


39

SOCIAL PROGRAM SEINE RIVER CRUISE AND GALA DINNER

ACCESS

On behalf of the International Federation of Placenta Associations, we invite you for an historical and poetical river cruise of Paris on Friday September 12th, 2014.

By public transportation, from the venue:

To reveal the heart of the City of light, the tour will lead you to discover all of the magic of the banks of the Seine river, which are enhanced by the most prestigious monuments which have marked the French history (Eiffel Tower, Invalides, Louvre Museum, Notre Dame, etc…) During this cruise, the IFPA gala dinner will be organized in the same time to amplify the magic beauty of Paris.

Walk to the Saint-Michel Notre Dame RER station Then take the RER C: from Saint Michel-Notre Dame to Pont de l’Alma Duration: Approximately 30 minutes By Metro: take

Alma-Marceau station

By car: free parking on the quay throughout the duration of the cruise

MEETING POINT Friday September 12th, 2014 Compagnie des Bateaux Mouches Port de la Conférence – Pont de l’Alma (departure and arrival) Seine, Right Bank, Paris 8th Organization: 7.00 pm: cocktail 7.45 pm: departure of the boat


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POSTER SESSIONS P1 = POSTER SESSION 1: WEDNESDAY 10TH SEPTEMBER 2014 P2 = POSTER SESSION 2: THURSDAY 11TH SEPTEMBER 2014


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POSTER SESSION 1 - Wednesday 10th September 2014 ANATOMY AND PATHOLOGY P1.1-N

Syncytial nuclear aggregates and villous capillary volume in IUGR placentas: A stereologybased study on virtual slides Mohamed ElMoursi1,2, Jens Stahlschmidt3, Darren Treanor1,3, Nigel Simpson1, 1 Leeds Institutes of Molecular Medicine, Leeds, UK, 2Department of Obstetrics and Gynaecology, Mansoura University Faculty of Medicine, Mansoura, Egypt, 3Department of Histopathology, Leeds Teaching Hospital NHS Trust, Leeds, UK

P1.2-N

A novel approach towards three dimensional reconstruction of placenta micro-architecture Mohamed ElMoursi1,2, Darren Treanor1,3, Nigel Simpson1,3, 1 Leeds Institutes of Molecular Medicine, Leeds, UK, 2Department of Obstetrics and Gynaecology, Mansoura University Faculty of Medicine, Mansoura, Egypt, 3Leeds Teaching Hospital NHS Trust, Leeds, UK

P1.3

Comparison of proliferation and differentiation in capillary wall of normal and diabetic placenta Marie Jirkovská1, Veronika Niedobová1, Martin Jadrníček1, Milena Moravcová1, Vratislav Krejčí1, Zdeněk Žižka1, 1 Charles University in Prague, First Faculty of Medinice, Prague, Czech Republic

P1.4-N

Novel and Efficient 3D Microscopic Analysis of Isolated Villous Trees of Human Placentas Eva Haeussner1, Christoph Schmitz1, Franz Edler von Koch2, Hans-Georg Frank1, 1 Ludwig-Maximilians-University, Munich, Germany, 2Dritter Order Hospital, Munich, Germany

P1.5

Placentation in Coendou prehensilis (Rodentia, Erethizontidae). Fabio Sergio Cury1, Phelipe Oliveira Favaron1, Carlos Eduardo Ambrósio1,2, 1 Faculty of Veterinary Medicine and Animal Sciences, São Paulo, São Paulo, Brazil, 2Faculty of Animal Sciences and Food Engineering, Pirassununga, São Paulo, Brazil

P1.6

Subtrophoblastic deposits in diabetic placentas observed by electron microscopy Roberta-- Rossi1, Maria Grazia Fiore1, Domenico Piscitelli1, Antonella Vimercati1, Graziana Arborea1, Leonardo Resta1, 1 Università degli Studi Aldo Moro, Bari, Italy, Italy

P1.7-N

Decidual acute atherosis in normal, diabetic and preeclamptic pregnancies: using revised diagnostic criteria Patji Alnæs-Katjavivi1, Fiona Lyall2, Borghild Roald4, Christopher Redman3, Annetine Staff1, 1 Women and Children’s Division, Oslo University Hospital (OUS), Oslo, Norway, 2Institute of Medical Genetics, University of Glasgow, Glasgow, UK, 3Nuffield Department of Obstetrics&Gynaecology, University of Oxford, Oxford, UK, 4Department of Pathology, Oslo University Hospital (OUS), Oslo, Norway

P1.8-N

Placental pathology in twin to twin transfusion syndrome twins after fetoscopic laser photocoagulation Naomi Tagawa1, Taizan Kamide1, Nagayoshi Umehara1, Kentaro Matuoka1, Haruhiko Sago1, 1 Seiiku Iryo Center, Tokyo, Japan

P1.9-N

Is Assisted Reproductive Technology associated with findings of placenta in monochorionicdiamniotic twins? Akiko Konishi1, Taizan Kamide1, Nagayoshi Umehara1, Kentaro Matsuoka1, Haruhiko Sago1, 1 National center of child health and development, Setagaya-ku Tokyo, Japan


42

P1.10

Placental pathology measures: can they be rapidly and reliably integrated into large-scale perinatal studies? Janet Catov1,2, W. Tony Parks1, 1 University of Pittsburgh School of Medicine, Pittsburgh, PA, USA, 2Magee Womens Research Institute, Pittsburgh, PA, USA

P1.11-N

Imaging analysis and pathological features of placental mesenchymal dysplasia(PMD) Akiko Tanuma1, Rie Kawaguchi1, Haruka Yanagisawa2, Tomohiro Tanemoto1, Nozomu Yanaihara1, Aikou Okamoto1 1 Department of Obstetrics and Gynecology, The Jikei University School of Medicine, Tokyo, Japan, 2 Department of Pathology, The Jikei University School of Medicine, Tokyo, Japan

P1.12-N

Morphology changes during post fixation and peri-implantation period in equine endometrium Gustavo Winter1, Andreza Souza1, Nicolas Cazales2, Maria Angélica Miglino3, Rodrigo Mattos1, 1 Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Brazil, 2Universidad de la Republica, Montevideo, Uruguay, 3Universidade de São Paulo, São Paulo, Brazil

P1.13-N

Do grossly normal- appearing placentas demonstrate histologic abnormalities? Senem Ates2, Patricia Monnier1,2, Anne-Elisabeth Mas1, Thierry Ducruet1, Dorothee Dal Soglio1, 1 Ste Justine Hospital, Montreal, QC, Canada, 2McGill University, Montreal, QC, Canada

P1.14-N

An unusual amnion with keratinized squamous epithelium and keratin cyst in the second trimester of a twin pregnancy Angela Salerno1, 1Ospedale maggiore AUSL-bologna, Bologna, Italy

P1.15-N

An excess of rare placental pathologies occur with abnormally invasive placenta (AIP) Alma Dzafic1,2, Vivek Gupta2,4, Christopher Koenig3,4, Ciaran Mannion3,4, Abdulla Al-Khan2,4, Nicholas P. Illsley2,4, Stacy Zamudio2,4, 1 St. Georges University School of Medicine, St Georges, Grenada, 2Hackensack University Medical Center, Division of Maternal-etal Medicine and Surgery, Hackensack, NJ, USA, 3Hackensack University Medical School Dept. of Pathology, Hackensack, NJ, USA, 4Hackensack University Center for Abnormal Placentation, Hackensack, NJ, USA

P1.16

Vascular alterations are key for developmental problems in the pre- and postnatal phases of cloned bovines Paulo Maiorka1, Phelipe Favaron2, Andrea Mess2, Caio dos Santos1, Flavio Meirelles3, Maria Angelica Miglino2, 1 Department of Pathology, School of Veterinary Medicine, University of São Paulo, São Paulo, SP, Brazil, 2 Department of Surgery, School of Veterinary Medicine, University of São Paulo, São Paulo, SP, Brazil, 3 Faculty of Animal Sciences and Food Engineering, University of São Paulo, São Paulo, SP, Brazil

P1.17

Decreased placental weight centile and increased birthweight:placental weight ratios in stillbirths suggests placental insufficiency even in stillbirths of “unknown” cause. Stephanie Worton1,2, Alexander Heazell1,2, 1 Maternal and Fetal Health Research Centre, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK, 2St. Mary’s Hospital, Central Manchester University Hospital NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK

ANGIOGENESIS P1.18

Role of Netrin-4 on placental angiogenesis Mbarka Dakouane-Giudicelli1, Guillaume Vallat1, Sammy Si Nacer1, Antoine Torre1, Marion Vallée1, Jean-Jacque Feige2, Nadia Alfaidy2, Philippe de Mazancourt1, 1 Université de Versailles-St-Quentin en Yvelines, Versailles, France, 2INSERM U1036 iRTSV /LAPV, Grenoble, France

P1.19-N

Glucocorticoids Inhibit Angiogenesis and Dysregulate Angiogenic Factors in the Human Placenta Emily Stratta1, Victoria Palin1, Colin Sibley1, Paul Brownbill1, Helen Bischof1, Sarah Jones1, Rebecca Jones1, 1 Maternal and Fetal Health Research Centre, University of Manchester, St Mary’s Hospital, Research Fifth Floor, Oxford Road, M13 9WL, UK


43

P1.20-N

The Role of Placental Growth Factor in Regulating Fetal Brain Vascular Development Matthew Rätsep1, Bruno Zavan1,2, Nicki Peterson1, Leandra Tolusso1, Vanessa Kay1, Nicole Ventura1, Stephen Pang1, Albert Jin1, Michael Adams1, Anne Croy1, 1 Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, Ontario, Canada, 2 Department of Cell, Tissue and Developmental Biology, Federal University of Alfenas, Alfenas, Minas Gerais, Brazil

P1.21-N

Hyperglycemia affects angiogenesis by means of mTOR pathway Asli Ozmen1, Busra Cetinkaya1, Gozde Unek1, Cem Sanhal2, Inanc Mendilcioglu2, Emin Turkay Korgun1, 1 Akdeniz University, Medical Faculty, Histology and Embryology Department, Antalya, Turkey, 2Akdeniz University, Medical Faculty, Obstetrics and Gynecology Department, Antalya, Turkey

P1.22-N

Changes in placental vasculature and pregnancy outcomes in HIV-antiretroviral drug exposed mice Eszter Papp1, Hakimeh Mohammadi1, Lena Serghides1, 1 University Health Network, Toronto, ON, Canada

P1.23

A2A adenosine receptor is required for adenosine-mediated angiogenesis in human umbilical vein endothelial cells from normal and pre-eclamptic cells: preliminary report. Carlos Escudero1, Felipe Troncoso1, Patricio Bertoglia2, Claudio Aguayo3, Jesenia Acurio1, 1 Vascular Physiology Laboratory, Group of Investigation in Tumor Angiogenesis (GIANT), Group of Research and Innovation in Vascular Health (GRIVAS Health), Department of Basic Sciences, Universidad del, Chillan, Chile, 2Obstetric and Gynecology Department, Herminda Martin Clinical Hospital, Chillan, Chile, 3Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepción, Concepcion, Chile

P1.24-N

A2B-mediated endothelial cell proliferation is associated with decoupling of the NO and VEGF signaling pathway during pre-eclampsia. Jesenia Acurio1, Felipe Troncoso1, Patricio Bertoglia2, Carlos Escudero1, 1 Vascular Physiology Laboratory, Group of Investigation in Tumor Angiogenesis (GIANT), Group of Research and Innovation in Vascular Health (GRIVAS Health), Department of Basic Sciences, Universidad del, Chillan, Chile, 2Obstetric and Gynecology Department, Herminda Martin Clinical Hospital, Chillan, Chile

P1.25

Placental Ribonuclease Inhibitor distribution in human placenta and decidua; expression by trophoblastic cells Nadine Pavlov1,3, Michel Moenner1,4, Jean-Louis Frendo1,5, Séverine Degrelle1,2, Tahar Kaabache6,2, Josette Badet1,2, 1 INSERM, UMRS-1139, Paris, France, 2Université Paris Descartes, Paris, France, 3Université de Lorraine, Nancy, France, 4IBGC CNRS UMR5095, Bordeaux, France, 5CNRS, UMR5547, Toulouse, France, 6INSERM, UMRS-1140, Paris, France

P1.26-N

Activation of the Transcription Factor Nrf2 in Human Umbilical Vein Endothelial Cells promotes Angiogenesis through VEGF Nisreen Kweider1, Jessica Lambertz1, Thomas Pufe1, Christoph Wruck1, Werner Rath2, 1 Department of Anatomy and Cell Biology; Medical Faculty; RWTH Aachen University, Aachen, Germany, 2Obstetrics and Gynecology; University Hospital of the RWTH Aachen, Aachen, Germany

BIOMARKERS P1.27

Volatile organic compounds in amniotic fluid during normal human pregnancy Régine Minet-Quinard1,4, Sylvie Ughetto2, Denis Gallot1,3, Damien Bouvier1,4, Didier Lemery1,3, Nicolas Goncalves-Menses4, Loïc Blanchon1, Vincent Sapin1,4, 1 R2D2 EA 7281 - Université d’Auvergne, Clermont-Ferrand, France, 2Medical Information Department CHU Clermont-Ferrand, Clermont-Ferrand, France, 3Obstretics and Gynaecology - CHU ClermontFerrand, Clermont-Ferrand, France, 4Biochemistry and Molecular Biology Department - CHU Clermont-Ferrand, Clermont-Ferrand, France

P1.28-N

Human Placental Lactogen and Placental Growth Factor Can Differentiate Small for Gestational Age from Appropriately Grown Infants Daniella Nice1, Katharine Hayden1, Lucy Higgins1,2, Edward Johnstone1,2, Alexander Heazell1,2, 1 Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK, 2Maternal and Fetal Health Research Centre, Institute of Human Development, University of Manchester, Manchester, UK


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P1.29-N

New biomarkers for endocrine disruption evaluation on microplate using a human placental cell line Anaïs Wakx1,2, Mélody Dutot1, Patrice Rat1, 1 Laboratoire de Toxicologie - Faculté de Pharmacie Paris Descartes, Paris, France, 2PremUp, Paris, France

COMPARATIVE/ANIMAL MODELS P1.30

Phenotypic variation in the trophoblast of the tammar wallaby Macropus eugenii Carolyn Jones1, Jeremy Skepper2, John Aplin1, Marilyn Renfree3, 1 University of Manchester, Manchester M13 9WL, UK, 2University of Cambridge, Cambridge CB2 3DY, UK, 3University of Melbourne, Melbourne, Victoria 3010, Australia

P1.31

Effects of a preconceptional and gestational multi-vitamin-mineral-omega3 supplementation on fetoplacental development in a rabbit model Eve Mourier1,4, Anne Tarrade1,4, Delphine Ralliard-Rousseau1,4, Thibaut Larcher2, Jean-Pierre ALBERT3, Marie-Christine Aubriere1,4, Michèle Dahirel1,4, Christophe Richard1,4, Rachel Levy5, Pascale ChavattePalmer1,4, 1 INRA UMR 1198 BDR, Jouy en Josas, France, 2INRA UMR 703 PAnTher, Nantes, France, 3INRA UCEA, Jouy en Josas, France, 4Fondation PremUp, Paris, France, 5INRA UMR UREN, Bobigny, France

P1.32

Ex vivo Endothelin Dependent Contraction of the Rat Remodeled Spiral Artery Ilana Ariel1, Galina Skarzinski1, Tally Kossovsky1, Vitali Belzer1, David Knigin1, Mogher Khamaisi2,3, Zaid Abassi3, Michael Busztyn1, 1 Hadassah-Hebrew University Medical Center, Jerusalem, Israel, 2Rambam Medical Center, Haifa, Israel, 3Rappaport Faculty of Medicine, Haifa, Israel

P1.33

A mouse model to study the role of autophagy in obesity induced placental dysfunction Alina Maloyan1, Sribalasubashini Muralimanoharan1, Leslie Myatt1, 1 University of Texas Health Science Center, San Antonio, Texas, USA

P1.34-N

Upregulation of Placental Autophagy in a Rat Model of Dexamethasone-Induced Fetal Growth Restriction Aisha Rasool1, Ainslie Garrod1, Elizabeth Cowley1, Susan Greenwood1, Elizabeth Cottrell1, 1 University of Manchester, Manchester, UK

P1.35-N

Supplementation With Inorganic Nitrate During Pregnancy Improves Maternal Uterine Artery Function and Placental Efficiency in Mice Elizabeth Cottrell1, Ainslie Garrod1, Mark Wareing1, Mark Dilworth1, Sarah Finn-Sell1, Susan Greenwood1, Philip Baker2, Colin Sibley1, 1 University of Manchester, Manchester, UK, 2University of Auckland, Auckland, New Zealand

P1.36

Independent captures of syncytin genes in the three clades of the order Rodentia in relation with placental diversity. François Redelsperger1, Cecile Vernochet1, Guillaume Cornelis1, Bud Tennant2, Eviatar Nevo3, Odile Heidmann1, Thierry Heidmann1, Anne Dupressoir1, 1 UMR8122 Institut Gustave Roussy, Villejuif, France, 2College of Veterinary Medicine, Cornell University, Ithaca, USA, 3University of Haifa, Haifa, Israel

P1.37-N

A Trial of Co-Cultivation: Confrontation of Breast Cancer Spheroids and Placenta Tissue Karolin Fröhlich1, Udo Markert1, Amelie Lupp2, 1 Placenta-Laboratories, Jena, Germany, 2Institute of Pharmacology and Toxicology, Jena, Germany

P1.38

Immunolocalization of the Cytochrome P450 enzymes: c17, NADPH reductase and aromatase in the vaginal mucosa of the Spix’s yellow-toothed cavy (Galea spixii) during the estrous cycle Amilton Santos1, Moacir Oliveira2, Diego Viana1, Maria Miglino1, Antonio Assis Neto1, 1 University of São Paulo, São Paulo, São Paulo, Brazil, 2Universidade Federal Rural do Semiárido, Rio Grande do Norte, Brazil

P1.39-N

Characterization and distribution of the caveolins-1 and -2 in water buffalo placenta Flávia Thomaz Verechia Pereira1, Vitor Trinca1, Ana Flávia Carvalho2, Maria Angelica Miglino3, 1Univ Estadual Paulista Unesp Dracena, Dracena, São Paulo, SP, Brazil, 2Faculty of Veterinary Medicine of São Joao da Boa Vista, UNIFEOB, São Joao da Boa Vista, São Paulo, SP, Brazil, 3University of São Paulo FMVZ USP, São Paulo, SP, Brazil


45

P1.40

Development of the subplacenta in Galea spixii (Rodentia, Caviidae) Ferdinando Bezerra1, Phelipe Favaron2, Andrea Mess2, Maria Angelica Miglino2, Moacir de Oliveira1, 1 Department of Animal Science, Universidade Federal Rural do Semi-Árido, Mossoro, Rio Grande do Norte, Brazil, 2Surgery Department, University of São Paulo, São Paulo, SP, Brazil

P1.41-N

Morphological and vascular changes in the corpus luteum during early gestation of bovine SCNT-derived pregnancies. Fábio Pinaffi1, Izabelle Jardim1, Juliano Sangalli1, Rafael Sampaio1, Flavio Meirelles1, Luciano Silva1, 1 University of São Paulo, Pirassununga, São Paulo, Brazil

P1.42

Dual closed-loop ex-vivo placental perfusion model: evidence for relevant LPS contamination and development of a procedure for depyrogenation. Tarushika Vasanthan1, Niels Rochow1, M. Firoz Mian1, Bryon DeFrance1, Gerhard Fusch1, Christoph Fusch1, 1 McMaster University, Hamilton, Ontario, Canada

P1.43

Womb to Womb: Developmental programming of fetal loss in adult female marmoset monkeys Julienne Rutherford1, Victoria deMartelly2, Corinna Ross4, Suzette Tardif3, 1University of Illinois at Chicago, Chicago, IL, USA, 2Emory University, Atlanta, GA, USA, 3University of Texas Health Science Center at San Antonio, San Antonio, TX, USA, 4Texas A&M University at San Antonio, San Antonio, TX, USA

P1.44-N

DNA global methylation and hydroximethylation in a carnivore placenta – coati (Nasua nasua, Procyonidae) Phelipe Favaron1, Amanda Martins1, Rodrigo Barreto2, Joao Carlos Morini Junior1, Flavio Meirelles2, Maria Angelica Miglino1, Lilian Oliveira2, Carlos Ambrosio2, 1 Department of Surgery, School of Veterinary Medicine, University of São Paulo, São Paulo, SP, Brazil, 2 Faculty of Animal Sciences and Food Engineering, University of São Paulo, Pirassununga, SP, Brazil

P1.45-N

Implantation and early parietal yolk sac development in Galea spixii (Rodentia, Caviidae) Phelipe Favaron1, Andrea Mess1, Moacir de Oliveira2, Maria Angelica Miglino1, 1 University of São Paulo, São Paulo, SP, Brazil, 2Department of Animal Science, Universidade Federal Rural do Semi-Árido, Mossoro, RN, Brazil

DEVELOPMENTAL BIOLOGY P1.46

Complex Regulation of RNA Splicing in the Syncytiotrophoblast Debra Goldman-Wohl1, Caryn Greenfield1, Iris Eisenberg-Loebl1, Galia Skarzinski2, Ronit HaimovKochman1, Tal Imbar1, Drorit Hochner-Celnikier1, Rotem Karni3, Ilana Ariel2, Simcha Yagel1, 1The Magda and Richard Hoffman Center for Human Placenta Research, Department of Obstetrics and Gynecology,Hebrew University-Hadassah Medical Center, Jerusalem, Israel, 2Department of Pathology,Hebrew University-Hadassah Medical Center, Jerusalem, Israel, 3IMRIC, Hebrew UniversityHadassah Medical School, Jerusalem, Israel

P1.47-N

Intrauterine growth enhancement and restriction are associated with alterations in term placenta morphology, morphometry and function in horses Pauline Peugnet1, Sarah Valentino1, Morgane Robles1, Michèle Dahirel1, Marie-Christine Aubrière1, Laurence Wimel2, Guy Duchamp3, Stéphane Chaffaux1, Cédric Dubois2, Fabrice Reigner3, Didier Serteyn4, Anne Tarrade1,5, Pascale Chavatte-Palmer1,5, 1 INRA, UMR1198 Biologie du Développement et Reproduction, Jouy en Josas, France, 2IFCE, Station Expérimentale de la Valade, Chamberet, France, 3INRA, UE1293, Nouzilly, France, 4Clinique Equine, Faculté de Médecine Vétérinaire, CORD, Université de Liège, Liège, Belgium, 5PremUp Fondation, Paris, France

P1.48

A rare ultrasonographic observation in the extraembryonic coelom at first trimester of pregnancy: did it predict the limb body wall complex? Seiji Sumigama1, Atsushi Enomoto1, Hiromi Hayakawa1, Tomomi Kotani1, Yukio Mano1, Hiroyuki Tsuda1, Fumitaka Kikkawa1, 1 Nagoya University Graduate School of Medicine, Nagoya, Japan


46

P1.49

Sexual differentiation of the external genitalia in embryos and fetuses in the Spix’s yellowtoothed cavy (Galea spixii) Amilton Santos1, Moacir Oliveira2, Diego Viana1, Antonio Assis Neto1, 1 University of São Paulo, São Paulo, São Paulo, Brazil, 2Universidade Federal Rural do Semiarido, Mossoro, Rio Grande do Norte, Brazil

P1.50

Efficiency of a SCNT bovine cloning program: the importance of the placentation time - a preliminary data. Izabelle Jardim1, Fábio Pinaffi1, Juliano Sangalli1, Rafael Sampaio1, Flavio Meirelles1, Luciano Silva1, 1 University of São Paulo, Pirassununga, São Paulo, Brazil

P1.51

The role of the phosphoinositol kinase (PI3K) p110α in regulating placental phenotype and fetal growth Amanda Sferruzzi-Perri1, Jaspreet Khaira1, Abigail Fowden1, Miguel Constancia1, 1 Centre for Trophoblast Research, University of Cambridge, Cambridge, UK

DIABETES/OBESITY P1.52

Maternal obesity is associated with altered placental expression of thyroid associated genes and increased fetal ft4 Melissa Suter1, Min Hu1, Melanie Arndt1, Kjersti Aagaard1, 1 Baylor College of Medicine, Houston, TX, USA

P1.53

Placental Whole Transcriptome Analysis Reveals Significant Differential Gene Expression Patterns Among Term Diabetic Gravidae R. Alan Harris1, Melissa Suter1, Melanie Arndt1, Min Hu1, Kjersti Aagaard1, 1 Baylor College of Medicine, Houston, TX, USA

P1.54-N

Maternal body-mass index and diabetes mellitus; independent associations with birthweight and placental weight?A population study of 74 202 pregnancies. 1,3 2 1,3 Ellen Marie Strøm-Roum , Tom Tanbo , Anne Eskild , 1 Department of Obstetrics and Gynecology, Akershus University Hospital, Lørenskog, Norway, 2 Department of Gynecology, Oslo University Hospital Rikshospitalet, Oslo, Norway, 3Institute of Clinical Medicine, University of Oslo, Oslo, Norway

P1.55

Placental alterations in a new experimental model of gestational diabetes generated by intrauterine programming in the offspring of mild diabetic rats Evangelina Capobianco1, Daiana Fornes1, Magalí Pelesson1, Verónica White1, Alicia Jawerbaum1, 1 CEFYBO-CONICET, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina

P1.56

Intergenerational effects of a maternal high fat diet on feto-placental development in a rabbit model. Anne Tarrade1,2, Marie-Christine Aubrière1,2, Delphine Rousseau-Ralliard1,2, Michèle Dahirel1,2, Eve Mourier1,2, Pascale Chavatte-Palmer1,2 1 INRA, UMR 1198 Biologie du Développement et Reproduction, Jouy-en-Josas, France, 2Fondation PremUp, Paris, France

P1.57

Activation of NFκB1 in Syncytiotrophoblasts Regulates the Expression of miR-210 and Mitochondrial Respiration in a Fetal Sex-Dependent Manner Alina Maloyan1, Sribalasubashini Muralimanoharan1, Chuming Guo1, Leslie Myatt1, 1 University of Texas Health Science Center, San Antonio, TX, USA

P1.58-N

LpPLA2 and Sirt1 - novel regulators of inflammation in placental tissue in diabetes and obesity? 1 1 1,2 1 1 Carolin Besenböck , Birgit Hirschmugl , Jelena Bilic , Gernot Desoye , Christian Wadsack , 1 2 Medical University of Graz, Dep. of Obstetrics and Gynecology, Graz, Austria, Medical University of Graz, Dep. of Histology and Embryology, Graz, Austria

P1.59-N

Characterisation of the release of placenta-derived exosome in gestational diabetes mellitus Carlos Salomon1, Suchismita Sarker1, Katherin Scholz-Romero1, Sebastian Illanes1,2, Murray Mitchell1, 1 Gregory Rice , 1 University of Queensland Centre for Clinical Research, Centre for Clinical Diagnostics, Royal Brisbane and Women’s hospital, Brisbane, Australia, 2Universidad de los Andes, Department of obstetric and Gynaecology, Santiago, Chile


47

P1.60

A periconceptional maternal hyperglycemia disrupts the feto-placental membrane fatty acid profiles in a rabbit model. Rousseau-Ralliard1, Emilie Derisoud1, Anne Tarrade1, Roselyne Brat1, Audrey Rolland1, Rene Delphine Thieme2, Anne Navarette-Santos2, Bernd Fischer2, Pascale Chavatte-Palmer1, 1 INRA, UMR 1198 Biology of Development and Reproduction, Jouy-en-Josas, France, 2MLU, Faculty of Medicine, Department of Anatomy and Cell Biology, Halle, Germany

P1.61-N

Investigating Fatty Acid Transport and β- Fatty Acid Oxidation (FAO) in Placentas exposed to Hyperglycemia Charlotte Hulme1,2, Melissa Westwood1,2, Alexander EP Heazell1,2, Jenny Myers1,2, 1 Maternal and Fetal Health Research Centre, Manchester, UK, 2Manchester Academic Health Sciences Centre, University of Manchester, UK

P1.62

Exercise before and during an obese mouse pregnancy restores some placental gene expression and transport function 1,2 1 , Daniella Duque1, Sarah Carr1, Barbara Musial1, Geraldine Gascoin1 , Denise Fernandez-Twinn Heather Blackmore , Suzan Ozanne1, 1 Institute of Metabolic Sciences, University of Cambridge, Cambridge, UK, 2Department of Neonatal Medicine, Angers University Hospital, Angers, France

P1.63

Evidence of placental endoplasmic reticulum stress in the pathophysiology of gestational diabetes mellitus Hong wa Yung1, Patji Alnæs-Katjavivi2, Annetine Staff2, Graham Burton1, 1 University of Cambridge, Cambridge, Cambridgeshire, UK, 2University of Oslo, Oslo, Norway

P1.64

Effects of short- and long-term type 1 diabetes on the placental extracellular matrix and fetal development in mice Juliane Sanches1,2, Rodolfo Favaro1, Estela Bevilacqua1, Telma Zorn1, 1 Universidade de São Paulo, São Paulo, São Paulo, Brazil, 2UniSalesiano, Araçatuba, São Paulo, Brazil

P1.65-N

Placental prolactin family levels are modified during gestation in the diabetic rat Pierrette Perimenis1,2, Emmanuelle Moitrot1, Pierre Gosset3, Elodie Eury4, Pierre Fontaine1,5, Philippe Froguel4,5, Anne Vambergue1,5, 1EA 4489-Perinatal environment and Growth, Lille, France, 2Department of Diabetology, Hospital Group of Catholic Institute of Lille (GHICL), Lille, France, 3Anatomopathological Department, Hospital Group of Catholic Institute of Lille (GHICL), Lille, France, 4CNRS-UMR8199, Lille, France, 5Department of Diabetology, University Hospital, CHRU Lille, Lille, France

P1.66

Mitochondria DNA damage in hyperglycemic-associated pregnancies Jusciele B. Moreli1, Janine H. Santos2, Simone Corrêa-Silva1,3, Débora C. Damasceno1, Marilza V. C. Rudge1, Estela Bevilacqua3, Iracema M. P. Calderon1, 1Post-Graduate Program in Gynecology, Obstetrics and Mastology, Botucatu Medical School, UNESP São Paulo State University, Botucatu, São Paulo, Brazil, 2Laboratory of Molecular Carcinogenesis, NIEHS, National Institute of Environmental Health Sciences, Durham, North Caroline, USA, 3 Department of Microbiology, Institute of Biomedical Sciences, USP University of São Paulo, São Paulo, São Paulo, Brazil

P1.67-N

Expressions of VEGF, VEFGR1, VEGFR2 and Akt in Pregestational Diabetic Human Placentas 1 1 1 2 1 Busra Cetinkaya , Asli Ozmen , Gozde Unek , Gul Bulbul , Emin Turkay Korgun , 1 Akdeniz University Medical Faculty Histology and Embryology Department, Antalya, Turkey, 2Antalya Training and Research Hospital Obstetrics and Gynecology Department, Antalya, Turkey

P1.68-N

Expression of mTOR and downstream target components in normal and gestational diabetic human term placenta Leyla Sati1, Bikem Soygur1, Pinar Sahin1, Ciler Celik-Ozenci1, Ramazan Demir1, 1 Akdeniz University School of Medicine, Department of Histology and Embryology, Antalya, Turkey

P1.69-N

Altered Expressions of Human Endogenous Retroviruses Syncytin1, Syncytin2 and Their Receptors in Human Normal and Gestational Diabetic Placenta Bikem Soygur1, Leyla Sati1, Ramazan Demir1, 1 Akdeniz University School of Medicine, Department of Histology and Embryology, Antalya, Turkey


48

P1.70-N

Paternal diet induced obesity has a fetal/placental growth restricted phenotype in a mouse model Natalie Binder1,2, Stephen Tong2, David Gardner1, Natalie Hannan2, 1 Department of Zoology, University of Melbourne, Victoria, Australia, 2Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, Australia

ENDOTHELIUM/VASCULATURE P1.71-N

An endothelial-mesenchymal transition occurs in primary placental cells in vitro - could this contribute to fetal growth restriction? Stefanie Swietlik1, Melissa Westwood1, Edward Johnstone1, John Aplin1, 1 University of Manchester, Manchester, UK

P1.72

Immunolocalisation of cytokeratin 7 in human umbilical mesenchymal stem cells, umbilical vein endothelial cells and human uterine microvascular endothelial cells Neven Ebrahim, Azlina A Razak, Jennifer A Sedcole, Olivia Volk & Lopa Leach. School of Life Sciences, Faculty of Medicine & Health Sciences, University of Nottingham, UK. Neven Ebrahim1, Azlina Razak1, Jennifer Sedcole1, Olivia Volk1, Lopa Leach1, 1 University of Nottingham, Nottingham, UK

P1.73

Kynurenine is a novel vasoactive factor in the maternal and placental vasculature Stephanie Worton1,2, Mark Wareing1,2, Susan Greenwood1,2, Alexander Heazell1,2, 1Maternal and Fetal Health Research Centre, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK, 2St. Mary’s Hospital, Central Manchester University Hospital NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK

P1.74

Surgical treatment of retained products of conception with preoperative endovascular embolization: effectiveness and pitfalls Yumiko Goto1,2, Kanako Mitsuzuka1, Yoshihiro Nishijima1, Atusko Togo1, Osamu Nishimura1, Takahiro Suzuki1, Toshinari Muramatsu2, Hitoshi Ishimoto1, 1 Dept of Obstetrics and Gynecology, Tokai University School of Medicine, Kanagawa, Japan, 2Dept of Obstetrics and Gynecology, Tokai University Hachioji Hospital, Tokyo, Japan

P1.75

Trophoblast debris contributes to the physiological maternal vascular adaptation to pregnancy by regulating endothelial cell proliferation. Jia Wei1, Qi Chen1, Jo James1, Peter Stone1, Larry Chamley1, 1 The University Of Auckland, Auckland, New Zealand

P1.76

Placenta accreta and sickle cell disease: a pathological model to explore the maternofetal border. Guillaume Bataillon1, Homa Adle-Biassette1, Aude Ricbourg2, Anne Thoury2, Yann Delpech2, Jean Louis Bénifla2, Françoise Cornélis1 1 Department of pathology, Hôpital Lariboisière, AP-HP, Paris, France, 2Department of obstetrics and gynecology, Hôpital Lariboisière, AP-HP, Paris, France

P1.77

Effect of the conceptus on uterine vascular perfusion during early pregnancy of SCNT cloned bovine embryos. Luciano Silva1, Fabio Pinaffi1, Izabelle Jardim1, Juliano Sangalli1, Rafael Sampaio1, Flavio Meirelles1, 1 University of São Paulo, Pirassununga, São Paulo, Brazil

P1.78

Role of oxidative stress status on the impaired eNOS-dependent relaxation in placental chorionic arteries of Intrauterine Growth Restricted (IUGR) and Macrosomic fetuses from Obese Mothers (FMOM). Daniela Schneider1, Cherie Hernandez1, Bernardo Krause1, Paola Casanello1,2, 1 Division of Obstetrics and Gynecology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile, 2Division of Pediatrics, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile


49

EPIGENETICS P1.79

Methylation and expression patterns of selected genes in first trimester placental tissue in small for gestational age pregnancies. Mariëtte Leeuwerke1, Stephanie Eilander1, Maurien Pruis2, Agnes Lendvai2, Jan Jaap Erwich1, Sicco Scherjon1, Torsten Plösch1, Jasper Eijsink1, 1 Department of Obstetrics and Gynaecology, University Medical Center Groningen, Groningen, The Netherlands, 2Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

P1.80-N

Epigenetic and Genetic Alterations of the Placental Tumor-suppressor Gene Rarres1 during human Placentogenesis Hanna Huebner1, Matthias Ruebner1, Pamela L. Strissel1, Regine Schneider-Stock3, Sven Kehl1, Wolgfgang Rascher2, Reiner Strick1, Andrea Hartner2, Matthias W. Beckmann1, Fabian B. Fahlbusch3, 1 Department of Gynecology and Obstetrics, University of Erlangen-Nürnberg, Erlangen, Germany, 2 Department of Pediatrics and Adolescent Medicine, University of Erlangen-Nürnberg, Erlangen, Germany, 3Department of Pathology, University of Erlangen-Nürnberg, Erlangen, Germany

P1.81-N

Gestational diabetes alters the expression of extracellular matrix proteins in the human placenta. Francisca Diaz1, Silvija Cvitic1, Gernot Desoye1, Ursula Hiden1, 1 Medical University of Graz, Graz, Styria, Austria

P1.82-N

Down regulation of placental PEG3 infers placental programming of maternal prenatal depression Anna Jensen1, Kieran O’Donnell3, Simon Tunster1, Ros John1, Vivette Glover2, 1 Cardiff University, Cardiff, UK, 2Imperial College London, London, UK, 3McGill University, Montreal, Canada

P1.83-N

High-salt intake during pregnancy modifies placenta phenotype at least until the third generation Maria A Peres1, Sonia F Soto1, Carina F Guimarães1, Rafaela C P Silva1, Ivone B de Oliveira1, Luzia N S Furukawa1, Joel C Heimann1, 1 University of São Paulo, São Paulo, SP, Brazil

P1.84

Analysis of 5-methyl Cytosine and 5- hydroxymethyl Cytosine content and distribution in bovine placental and fetal tissues after somatic nuclear reprogramming Michel Guillomot1, Audrey Prezelin1, Helene Jammes1, Evelyne Campoin1, Helene Kiefer1, Nathalie Beaujean1, Tiphaine Aguirre1, Helene Jammes1, 1 INRA, Jouy en Josas, France

P1.85-N

Sex-specific epigenetic impact of preconceptional maternal weight loss on foeto-placental development Polina Panchenko1,2, Mélanie Jouin1, Luc Jouneau1, Marion Lemaire1, Claudine Junien1,3, Anne Gabory1, 1 INRA, UMR1198 Biologie du Développement et Reproduction, Jouy-en-Josas, France, 2University Pierre and Marie Curie (UPMC), Paris, France, 3Université de Versailles Saint-Quentin-en-Yvelines, Versailles, France

P1.86-N

Histone deacetylase activity and nitric oxide control the expression of eNOS and arginase-2 in human umbilical artery endothelium in intrauterine growth restriction. Bernardo Krause1, Cherie Hernandez1, Daniela Schneider1, Paola Casanello1,2, 1 Division of Obstetrics & Gynecology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile, 2Division of Pediatrics, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile

P1.87

Effect of maternal BMI on DNA methylation and hydroxymethylation, a novel epigenetic modification, in the placenta Kohzoh Mitsuya1, Ashley Parker1, Lu Liu2, Jianhua Ruan2, Leslie Myatt1, 1 Center for Pregnancy and Newborn Research, Department of Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio, Texas, USA, 2Department of Computer Science, University of Texas at San Antonio, Texas, USA


50

P1.88-N

DNA global epigenetic modifications in normal and cloned bovine placentome Rodrigo da Silva Nunes Barreto1, Ana Carolina Furlanetto Mançanares1, Flávia Thomaz Verechia Pereira3, Felipe Perecin2, Flávio Vieira Meirelles2, Lilian de Jesus Oliveira1, 1Faculdade de Medicina Veterinária e Zootecnia - Universidade de São Paulo, São Paulo/SP, Brazil, 2 Faculdade de Zootecnia e Engenharia de Alimentos - Universidade de São Paulo, Pirassununga/SP, Brazil, 3Faculdade de Zootecnia - Universidade Estadual Paulista “Júlio de Mesquit Filho”, Dracena/ SP, Brazil

FETAL GROWTH RESTRICTION P1.89

Placental findings in late-onset small for gestational age births without Doppler signs of placental insufficiency and their impact in neurodevelopmental outcome Alfons Nadal1, Miguel Parra-Saavedra1,2, Francesca Crovetto1,3, Stefania Triunfo1,4, Stefan Savchev1, Anna Peguero1, Eduard Gratacós1, Francesc Figueras1, 1 Hospital Clínic, Barcelona, Spain, 2Centro de Diagnóstico de Ultrasonido e Imágenes, Barranquilla, Colombia, 3Ospedale Maggiore Policlinico, Milano, Italy, 4Catholic University of the Sacred Heart, Roma, Italy

P1.90

Placental pathology versus clinical risk of fetal growth restriction Jerzy Stanek1, Jacek Biesiada1, 1 Cincinnati Children’s Hospital, Cincinnati, Ohio, USA

P1.91

Clustering of clinical and placental phenotypes in fetal growth restriction Jerzy Stanek1, Jacek Biesiada1, 1 Cincinnati Children’s Hospital, Cincinnati, Ohio, USA

P1.92

Placental PATHOLOGY IN EARLY-ONSET VERSUS LATE-ONSET FETAL GROWTH RESTRICTION Jerzy Stanek1, 1 Cincinnati Children’s Hospital, Cincinnati, Ohio, USA

P1.93

Partial progesterone deprivation up-regulates transcription of cell cycle control and proapoptotic genes in rat placentas Maie Al-Bader1, Aseel El-Farra1, Kilarkaje Narayana2, Abeer Al-Abdallah3, Abdeslam Mouihate1, Khalid Khan2, Alexander Omu4, 1 Department of Physiology, Faculty of Medicine, Kuwait University, Kuwait, Kuwait, 2Department of Anatomy, Faculty of Medicine, Kuwait University, Kuwait, Kuwait, 3Department of Pathology, Faculty of Medicine, Kuwait University, Kuwait, Kuwait, 4Department of Obstetrics and Gynecology, Faculty of Medicine, Kuwait University, Kuwait, Kuwait

P1.94-N

IUGR in rats is associated with changes in placental expression of MTAs Mariam Al-Qaryan1, Narayana Kilarkaje2, Abdeslam Mouihate1, Maie Al-Bader1, 1 Kuwait University, Department of Physiology, Kuwait, Kuwait, 2Kuwait University, Department of Anatomy, Kuwait, Kuwait

P1.95

VEGF165 Gene Delivery to Uterine Arteries by Ultrasound-Mediated Cavitation of PlasmidConjugated Microbubbles Prevents Fetal Growth Restriction in Transgenic Mouse Model of Placental Insufficiency Terry Morgan1, 1 OHSU, Portland, OR, USA

P1.96

The outcome of severe growth-restricted infants at 28 days after birth and abnormalities of umbilical cord insertion Aya Yoshida1, Nagayoshi Umehara1, Katsusuke Ozawa2, Kiyotake Ichizuka3, Kei Tanaka4, Tomohiro Tanemoto5, Hirohumi Ishikawa6, Takeshi Murakoshi7, Jun Sasahara8, Keisuke Ishii8, Kenji Kiyoshi9, Haruhiko Sago1, 1 National Center for Child Health and Development, Tokyo, Japan, 2Miyagi Children Hospital, Miyagi, Japan, 3Showa University, Tokyo, Japan, 4Kyorin University, Tokyo, Japan, 5The Jikei University School of Medicine, Tokyo, Japan, 6Kanagawa Children’s Medical Center, Kanagawa, Japan, 7Seirei Hamamatsu General Hospital, Hamamatsu, Japan, 8Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka, Japan, 9Hyogo Prefecture Kobe Children’s Hospital, Hyogo, Japan


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P1.97-N

11-beta-hydroxysteroid dehydrogenase-1 inhibition mediated intrauterine growth restriction parallels with altered expressions of cell cycle control genes in rat placentas Aseel El-Farra1, Kilarkajea Narayan2, Abeer Al-Abdallah3, Abdeslam Mouihate1, Maie Al-bader1, 1 Physiology dept. Faculty of medicine, Kuwait University, Kuwait, Kuwait, 2Anatomy dept. Faculty of medicine, kuwait univ., kuwait, Kuwait, 3pathology dept. Faculty of medicine, Kuwait univ, kuwait, Kuwait

P1.98-N

Female Offspring from Sildenafil Citrate-Treated Pregnancies Exhibit Impaired Glucose Tolerance. Lewis Renshall1, Mark Dilworth1, Elizabeth Cottrell1, Ainslie Garrod1, Elizabeth Cowley1, Susan Greenwood1, Mark Wareing1, 1 Maternal and Fetal Health Research Centre, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK

P1.99

Altered placental expression levels of nutrient transporters after bilateral uterine artery ligation in the rat Alexandra Gellhaus2, Eva Nüsken1, Isabelle Swoboda1, Elisabeth Kühnel2, Maria Wohlfahrt1, Gregor Lippach1, Jörg Dötsch1, Kai-Dietrich Nüsken1, 1 Department of Paediatrics and Adolescent Medicine, University of Cologne, Cologne, Germany, 2 Department of Gynecology and Obstetrics, University Hospital Essen, Essen, Germany

P1.100-N

Increased fetal weight in wild-type mice following melatonin treatment: effect on uterine artery function Hannah Morgan1, Hymke Moens1, Philip Baker2, Susan Greenwood1, Colin Sibley1, Mark Wareing1, Mark Dilworth1, 1 Maternal and Fetal Health Research Centre, University of Manchetser, Manchester, UK, 2Liggin’s Institute, University of Auckland, Auckland, New Zealand

P1.101

Microvascular regression contributes to placental vascular impoverishment in fetal growth restriction John D Aplin1, Toluwalope Junaid1, Paul Brownbill1, Edward D Johnstone1, 1 University of Manchester, Manchester, UK

P1.102-N

Adenoviral-Mediated Placental Gene Transfer of IGF-1 Corrects Placental Insufficiency via restoring Placental Endothelial Progenitor Cells khaled Omar1, Louis Muglia1, Mounira Habli1,2, 1 Cincinnati Childrens Hospital Medical Center, Cincinnati, Ohio, USA, 2GoodSamaritan Hospital, Cincinnati, Ohio, USA

P1.103

Low molecular weight heparin (LMWH) and low-dose aspirin treatment in patients with preexisting high-risk conditions improves pregnancy outcomes when such pregnancies are complicated in addition by unexplained low maternal serum PAPP-A (LPAPP-A). Alexander Kofinas1,2, George Guirguis3, 1 New York Methodist Hospital, Weill Cornell Medical College, Brooklyn New, York, USA, 2Kofinas Perinatal PC, Garden City, New York, USA, 3Atlantic Health-Rutgers New Jersey Medical School, New Brunswick, New Jersey, USA

P1.104-N

The expressions of Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and Peroxiredoxin 6 (Prdx6) proteins in normal and pathologic rat and human placentas Nuray Acar1, Hakan Soylu1, Imren Edizer1, Ozlem Ozbey1, Ismail Ustunel0, 1 Akdeniz University Faculty of Medicine Department of Histology and Embryology, Antalya, Turkey

P1.105

IGF-II Analogue Effects on Placental Efficiency and Fetal Growth in Normal and FGR Mouse Models Jayne Charnock1, Mark Dilworth1, John Aplin1, Melissa Westwood1, Colin Sibley1, Ian Crocker1, 1 The University of Manchester, Manchester, UK

P1.106-N

Foetal and umbilical vascular reactivity in a model of IUGR through gradual uterine artery occlusion in guinea pigs. Daniela Scheneider1, René Alegría1, Emilio Herrera3, Marcelo Farías1, Paola Casanello1,2, Bernardo 1 Krause , 1 Division of Obstetrics and Gynecology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile, 2Division of Pediatrics, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile, 3Laboratorio de Función y Reactividad Vascular, ICBM, Universidad de Chile, Santiago, Chile


52

P1.107-N

Low placental growth factor in the maternal circulation is associated with abnormal placental morphology in fetuses with suspected intrauterine growth restriction Samantha Benton1,5, Julien Yockell-Lelièvre2, David Grynspan4,3, Laura Magee1,5, Yuxiang Hu1,5, Andree Gruslin2,3, Peter von Dadelszen1,5, 1 University of British Columbia, Vancouver, BC, Canada, 2Ottawa Hospital Research Institute, Ottawa, ON, Canada, 3University of Ottawa, Ottawa, ON, Canada, 4Children’s Hospital of Eastern Ontario, Ottawa, ON, Canada, 5Child and Family Research Institute, Vancouver, BC, Canada

P1.108

TROP2 and miR125b1: Two possible players in the pathogenesis of preeclampsia complicated by foetal growth restriction. Caterina Licini1, Chiara Avellini1, Giovanni Tossetta1, Chiara Tersigni2, Nicoletta Di Simone2, Stefano Giannubilo1, Fabiola Olivieri1, Mario Castellucci1, Daniela Marzioni1, 1 Università Politecnica delle Marche, Ancona, Italy, 2Università Cattolica del Sacro Cuore, Roma, Italy

FETAL MEMBRANE P1.109-N

Effects of Prostaglandin E2 on Lysyl Oxidase-Mediated Collagen Cross-Linking in Human Amnion Fibroblasts Chao Liu2, Wangsheng Wang2, Gang Sun1, 1 Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, 2School of Life Sciences, Fudan University, Shanghai, China

P1.110-N

In vitro formation of capillary tubules from stem cells of the bovine yolk sac with prospects for therapeutic application Celina A. F. Mançanares1,3, Vanessa C. Oliveira2, Ana Flavia Carvalho1, Flavio V. Meirelles3, Maria Angélica Miglino2, Carlos Eduardo Ambrosio3, 1 UNIFEOB - Centro Universitário da Fundação de Ensino Octávio Bastos, São João da Boa Vista, Brazil, 2USP -Universidade de São Pau, São Paulo, Brazil, 3FZEA - Universidade De São Paulo, Pirassununga, Brazil

P1.111

All-trans retinoic acid regulates aquaporin-3 expression and related cellular membrane permeability in human amniotic environment Cécile Prat1, Aurélie Comptour1, Damien Bouvier1,2, Geoffroy Marceau1,2, Corinne Belville1,3, Denis Gallot1,4, Vincent Sapin1,2, Loïc Blanchon1, 1 EA 7281 R2D2 UdA, Clermont-Ferrand, France, 2Biochemistry and Molecular Department - CHU Clermont-Ferrand, Clermont-Ferrand, France, 3GReD MR INSERM 1103 CNRS 6247, ClermontFerrand, France, 4Obstetrics and Gynaecology - CHU Clermont-Ferrand, Clermont-Ferrand, France

P1.112-N

Role of EG-VEGF (endocrine gland derived endothelial growth factor) in the human fetal membranes. Thibaut Mouchet1, Wael Traboulsi1, Camille Dunand1,2, Vanessa Garnier1, sophie Brouillet1,2, Jean Guibourdenche3, Pascale HOffmann1,2, Mohamed Benharouga4, Jean-jacques Feige1, Nadia Alfaidy1,2, 1 INSERM U1036, Grenoble, France, 2Grenoble hospital, Grenoble, France, 3Cochin Hospital INSERM U767, Paris, France, 4University Joseph Fourier, Grenoble, France

P1.113-N

A scanning electron microscopy study of microcotiledonary development of equine placenta throughout gestation Andreza Souza1, Gustavo Winter1, Nicolas Cazales2, Maria Angélica Miglino3, Rodrigo Mattos1, 1 Universidade Federal Do Rio Grande Do Sul, Porto Alegre/ Rio Grande Do Sul, Brazil, 2Universidad de la Republica, Montevideo, Uruguay, 3Universidade de São Paulo, São Paulo/ São Paulo, Brazil

P1.114

Quantification of NORs in water buffalo placenta (Bubalus bubalis) Ana Flávia Carvalho1, Evandro Franco de Lima1, Celina Almeida Furlanetto Mançanares1, Juliana Montovani Thomaz1, Ana Carolina Furlanetto Mançanares3, Maria Angélica Miglino3, Flávia Thomaz Verechia Pereira2, 1 Centro Universitário da Fundação de Ensino Octávio Bastos-UNIfeob, São João da Boa Vista, São Paulo, SP, Brazil, 2Univ Estadual Paulista-UNESP, Dracena, São Paulo,SP, Brazil, 3Universidade de São Paulo- FMVZ, USP, São Paulo, SP, Brazil


53

GENE EXPRESSION/REGULATION P1.115-N

Novel codogenic retrotransposable MART-genes in the human and murine placentogenesis. Christine Henke1, Matthias Ruebner1, Maria-Theresa Schubert1, Pamela L. Strissel1, Sven Kehl1, Florian Faschingbauer1, Matthias W. Beckmann1, Reiner Strick1, 1 University-Clinic Erlangen, Department of Gynaecology and Obstetrics, Laboratory for Molecular Medicine, Erlangen, Germany

P1.116

Lack of Correlation between Human Placental Gene Expression and RNA Integrity Number (RIN) or Time to Collection Christopher J Stodgell1, Richard K Miller1, Linda Salamone1, Jeffrey Murray2, Jia Chen3, Luca Lambertini3, Eric Schadt3, Lisa Littman3, Philip Landrigan3, Kjersti Aagaard4, Charlotte Hobbs5, Edward B Clark6, Michael Varner6, Nancy Dole7, Jennifer Culhane8, James Swanson9, Natalie Thiex10, Tamara Busch2, Carol Kasten11, John Moye12, 1 2 University of Rochester, School of Medicine and Dentistry, Rochester, NY, USA, University of Iowa, 3 School of Medicine, Iowa City, IA, USA, Icahn School of Medicine at Mt. Sinai, New York, NY, USA, 4 Baylor College of Medicine, Houston, TX, USA, 5University of Arkansas College of Medicine, Little Rock, AK, USA, 6University of Utah School of Medicine, Salt Lake City, UT, USA, 7University of North Carolina, School of Medicine, Chapel Hill, NC, USA, 8The Children’s Hospital of Philadelphia, Philadelphia, PA, USA, 9University of California, School of Medicine, Irvine, CA, USA, 10South Dakota State University, Brookings, SD, USA, 11US Food and Drug Administration, Silver Spring, MD, USA, 12 National Children’s Study, National Institute of Health, Bethesda, MD, USA

P1.117

RNA-seq analysis of placental transcriptional landscape in normal and complicated pregnancies Siim Sõber1, Mario Reiman1, Kristiina Rull1,2, Pille Vaas2, Jaana Männik1,3, Maris Laan1, 1 Human Molecular Genetics Group, Institute of molecular and cellular biology, University of Tartu, Tartu, Estonia, 2Department of Obstetrics and Gynecology, Tartu University Hospital, Tartu, Estonia, 3 Department of Biochemistry, Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee, USA

P1.118

Evolution of placental functions through gene co-option. Brian Cox1, Jordana Lowe1, 1 University of Toronto, Toronto, Ontario, Canada

P1.119-N

Global rewiring of molecular networks in placenta previa and accreta Roberta Hannibal1, Janet Song1, Ann Folkins1, Deirdre Lyell1, Amy Heerema-McKenney1, Julie Baker1, 1 Stanford University School of Medicine, Stanford, CA, USA

P1.120-N

Placental FTO gene expression is correlated with maternal fatty acid concentration in blood at early and late pregnancy. Mildrey Mosquera1,2, Jane K Cleal1, Sheila J Barton1, John W Holloway1, Charlene Sibbons3,1, Hazel M Inskip1, Philip C Calder1, Cyrus Cooper1, Keith M Godfrey1, Rohan M Lewis1, SWS study Group1, 1 University of Southampton, Southampton, UK, 2Universidad del Valle, Cali, Colombia, 3University of Surrey, Surrey, UK

P1.121

Expression of midkine in the human placenta: a possible role for early placental development Atsuko Togo1, Yumiko Goto1, Kanako Mitsuzuka1, Hidetoshi Kanno1, Atsuya Narita1, Satoshi Asai1, Masaki Miyazawa1, Hitoshi Ishimoto1, 1 Dept. of OBGYN, Tokai University School of Medicine, Isehara, Kanagawa, Japan

P1.122

Drug transporter expression during in vitro differentiation of first-trimester and term human trophoblasts Paul Berveiller1, Séverine Degrelle1, Nadine Segond1, Audrey Chissey1, Danièle Evain-Brion1, Sophie Gil1 1 UMR-S 1139, INSERM, University of Paris Descartes, Paris, France

P1.123

Pilot study: Yolk sac vascular development and VEGF expression during early gestation in bovines derived from nuclear transfer Andrea Mess1, Ana Claudia Carreira2, Paula Fratini1, Phelipe Favaron1, Flavio Meirelles3, Maria Angelica Miglino1, 1 Department of Surgery, Faculty of Veterinary Medicine, University of São Paulo, São Paulo, SP, Brazil, 2 Department of Chemistry, University of São Paulo, São Paulo, SP, Brazil, 3Faculty of Animal Sciences and Food Engineering, University of São Paulo, São Paulo, SP, Brazil


54

P1.124

Delta-like protein 1 and Notch1 Promoter methylation and Protein Expression in Placenta Yota Shimanuki1, Hiroyuki Mitomi2, Shintaro Makino1, Atsuo Itakura1, Satoru Takeda1, Takashi Yao1, 1 Juntendo University Faculty of Medicine, Tokyo, Japan, 2Dokkyo Medical University School of Medicine, Tochigi, Japan

GENOMICS P1.125

Expression Quantitative Trait Loci in Placenta Tissues from the National Children’s Study Reveal Developmental Origins of Human Complex Diseases Ke Hao1, Antonio Di Narzo1, Jia Chen1, Joel Dudley1, Nina Horowitz1, Eric Schadt1, Luca Lambertini1, Philip Landrigan1, Kjersti Aagaard2, Charlotte Hobbs3, Michael Varner4, Nancy Dole5, Jennifer Culhane6, James Swanson7, Natalie Thiex8, Jeffrey Murray9, John Moye10, Carol Kasten11, Christopher Stodgell12, Richard Miller12, 1Icahn School of Medicine at Mount Sinai, New York, NY, USA, 2Baylor College of Medicine, Houston, TX, USA, 3University of Arkansas, College of Medicine, Little Rock, AR, USA, 4University of Utah, Salt Lake City, UT, USA, 5University of North Carolina, Chapel Hill, NC, USA, 6The Children’s Hospital of Philadelphia, Philadelphia, PA, USA, 7University of California, Irvine, CA, USA, 8South Dakota State University, Brookings, SD, USA, 9University of Iowa, Iowa City, IA, USA, 10National Children’s Study, National Institutes of Health, Bethesda, MD, USA, 11U.S. Food and Drug Administration, Silver Spring, MD, USA, 12University of Rochester, School of Medicine and Dentistry, Rochester, NY, USA

GESTATIONAL TROPHOBLASTC DISEASE P1.126-N

Core 2 β1, 6-N acetylglcosaminyl transferase may regulate cell invasion in choriocarcinoma Kaoru Niimi1, Eiko Yamamoto1, Yoko Miwa1, Kimihiro Nishino1, Yukio Mano1, Seiji Sumigama1, Tomomi Kotani1, Fumitaka Kikkawa1, 1 Nagoya University, Nagoya, Aichi, Japan

P1.127-N

Transcriptional regulation of human N-acetylglucosaminyltransferase IVa gene in trophoblasts Yoko Miwa1, Eiko Yamamoto1, Kanako Shinjo2, Kaoru Niimi1, Kimihiro Nishino1, Yukio Mano1, Seiji Sumigama1, Tomomi Kotani1, Fumitaka Kikkawa1, 1 Nagoya University, Nagoya City, Japan, 2Toyota Kosei Hospital, Toyota City, Japan

P1.128

A combination of a diploid fetus and triploid hydatidiform mole originated from single pair of one ovum and one sperm Seiji Sumigama1, Toshimichi Yamamoto1, Yukio Mano1, Hiroyuki Tsuda1, Tomomi Kotani1, Takafumi Ushida1, Tomoko Nakano1, Yoko Miwa1, Kaoru Niimi1, Eiko Yamamoto1, Fumitaka Kikkawa1, 1 Nagoya University Graduate School of Medicine, Nagoya, Japan

P1.129-N

EG-VEGF and its receptors are deregulated in complete hydatiform moles: Potential role in placental tumor development. Wael TRABOULSI1, Hossein BOUFFETAL3, Touria Aboussaouira3, Naima SAMOUH3, Mohamed BENHAROUGA2, Jean-Jacques FEIGE1, Nadia ALFAIDY1, 1 INSERM U1036, GRENOBLE, France, 2joseoh fourier university, GRENOBLE, France, 3CHU Casablanca, Casablanca, Morocco

P1.130-N

Elaboration of a national biobank for the study of gestational trophoblastic diseases. Pierre-Adrien Bolze1,4, Benoît You2,4, Jérôme Massardier3,4, Touria Hajri4, François Golfier1,4, 1 2 Lyon Sud University Hospital, Gynecology Obstetrics Department, Lyon, France, Lyon Sud University Hospital, Medical Oncology Department, Lyon, France, 3Hôpital Femme Mère Enfant University Hospital, Prenatal Diagnosis Department, Lyon, France, 4French Reference Centre for Trophoblastic Diseases, Lyon, France

HORMONES, GROWTH FACTORS, CYTOKINES P1.131

Maternal age and serum concentration of human chorionic gonadotropin in early pregnancy. Camilla Haavaldsen1,2, Peter Fedorcsak3, Tom Tanbo3,2, Anne Eskild1,2, 1Akershus University Hospital, Departments of Gynecology and Obstetrics, Lørenskog, Norway, 2 University of Oslo, Institute of Clinical Medicine, Oslo, Norway, 3Oslo University Hospital, Rikshospitalet, Department of Gynecology, Section for Reproductive Medicine, Oslo, Norway

P1.132

Delivery and intracellular turnover of insulin-like growth factor I (IGF-I) delivered to human placenta using quantum dots Magdalena Karolczak-Bayatti1, Karen Forbes1, Lynda K. Harris1, Melissa Westwood1, John D. Aplin1, 1 University of Manchester, Manchester, UK


55

P1.133-N

A systems approach to understanding placental signalling. Hugo Creeth1, Simon Tunster1, Jessica Eddy1, Anthony Isles1, Rosalind John1, 1Cardiff University, Cardiff, UK

P1.134

Characterisation of the Tumor-Suppressor Gene Gastrokine 2 in the Human Placenta Fabian Fahlbusch1, Hannah Bartunik1, Gudrun Volkert1, Andrea Hartner1, Hanna Huebner2, Matthias Ruebner2, Sven Kehl2, Regine Schneider-Stock3, Wolfgang Rascher1, 1Department of Pediatrics and Adolescent Medicine, Friedrich-Alexander University ErlangenNürnberg, Erlangen, Germany, 2Department of Obstetrics and Gynaecology, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany, 3Experimental Tumorpathology, FriedrichAlexander University Erlangen-Nürnberg, Erlangen, Erlangen, Germany

P1.135

Placental Hormone Contribution to Fetal Brain Damage Anna Penn1, Wendy Koss1, Megha Agrawal1, Suresh Volate1, Danielle Leuenberger2, Marianna Kiraly2, Anca Pasca2, Karen Chisholm2, 1 Children’s National Medical Center, Washington DC, USA, 2Stanford University, Stanford CA, USA

P1.136-N

Antiretroviral-therapy (ART) induced adverse pregnancy outcomes: the potential role of progesterone Eszter Papp1, Hakimeh Mohammadi1, Lena Serghides1, 1 University Health Network, Toronto, ON, Canada

P1.137-N

Placental angiogenic and hormonal factors are affected by maternal thyroid dysfunction in rats Juneo Silva1, Natalia Ocarino1, Rogeria Serakides1, 1 Departamento de Clínica e Cirurgia Veterinárias, Universidade Federal de Minas gerais, Belo Horizonte/Minas Gerais, Brazil

P1.138

Epigenetic regulation of placental endocrine function Simon Tunster1, Hugo Creeth1, Rosalind John1, 1 Cardiff University, Cardiff, UK

P1.139-N

Prenatal maternal stress alters placental endocrine functions: fetal sex implications Joey St-Pierre1, David P. Laplante2, Guillaume Elgbeili2, Suzanne King2,3, Cathy Vaillancourt1, 1 INRS-Institut Armand Frappier and BioMed research Centre, Laval, Quebec, Canada, 2Douglas Institute Research Center, Montreal, Quebec, Canada, 3McGill University Montréal, Montreal, Quebec, Canada

HYPOXIA P1.140-N

Mitochondrial content in cytotrophoblast cells under hypoxic conditions Chiara Mandò1,2, Gaia Maria Anelli1,2, Chiara Novielli1,2, Veronica Clivio1,2, Irene Cetin1, 1 University of Milan, Dept Biomedical and Clinical Sciences L.Sacco, Milan, Italy, 2University of Milan, Center for Fetal research Giorgio Pardi, Milan, Italy

P1.141-N

The association of maternal haemoglobin concentrations with birthweight and placental weight: a population study of 56 897 pregnancies in Norway Sandra Larsen1, Samantha S. Adams1, Anne Eskild1,2, 1 Department of Obstetrics and Gynecology, Akershus University Hospital, Lørenskog, Norway, 2 Institute of Clinical Medicine, Faculty of Medicine University of Oslo, Oslo, Norway

P1.142-N

Hypoxia adapts placental mitochondrial function in association with changes in placental transport phenotype Josephine Higgins1, Andrew Murray1, Abigail Fowden1, Amanda Sferuzzi-Perri1, 1 University of Cambridge, Cambridge, UK

IMAGING P1.143-N

Analysis of placental elasticity using Virtual Touch Tissue Quantification during pregnancy Takako Ohmaru1, Yasuyuki Fujita1, Maiko Sugitani1, Kotaro Fukushima1, Kiyoko Kato1, 1 Kyushu University, Fukuoka, Japan

P1.144

Ultrasound monitoring of fetal and placental growth and vascularisation in the rabbit Eve Mourier1, Christophe RICHARD1, Pascale CHAVATTE-PALMER1, 1 INRA UMR 1198 BDR, Jouy en Josas, France


56

P1.145-N

Ex-vivo magnetic resonance angiography to explore placental vascular anatomy Anne-Claire Chabot-Lecoanet1,2, Jie Duan1, Christo Christov2,4, Olivier Morel1,2, Marine Beaumont3, 1 IADI Inserm U947, Lorraine university, 4 Rue du Morvan, 54500, Vandoeuvre lès Nancy, France, 2 Regional maternity of university of Nancy, 10 Rue Heydenreich, 54000 Nancy, France, 3Inserm CIC-IT 1433, 4 Rue du Morvan, 54500, Vandoeuvre lès Nancy, France, 4Commun microscopy utility, Lorraine University, 9, Avenue de la forêt de Haye, 54500, Vandoeuvre-lès- Nancy, France

P1.146-N

Quantification of the utero-placental vascularisation with the 3D Doppler: impact of the machine settings Jie Duan1, Anne-claire Chabot-lecoanet1,2, Estelle Perdriolle-Galet1,2, Olivier Morel1,2, 1 IADI,Inserm U947, University of Lorrain, 4 Rue du Morvan, 54500, Vandoeuvre lès Nancy, France, 2 Regional maternity of university of Nancy, 10 Rue Heydenreich, 54000 Nancy, France

P1.147-N

Assessing the Usability of Digital Images of Human Placenta with Multi-scale Filtering Methods Nen Huynh1,4, Jen-Mei Chang1, Philip Katzmann2,3, Richard Miller2,3, John Moye3, Carolyn Salafia4, 1California State University, Long Beach, Long Beach, CA, USA, 2University of Rochester School of Medicine, Rochester, NY, USA, 3Project 18 National Children’s Study, National Institutes of Child Health and Human Development, USA, 4Placental Analytics, Larchmont, NY, USA

P1.148

Not submitted Guillermina Girardi1,2, Jennifer Fraser3, Maria Laura Bertolaccini1, Ross Lennen2, Regina Vontell1, Gary Hutchison3, 1 King’s College London, London, UK, 2University of Edinburgh, Edinburgh, UK, 3Napier University, Edinburgh, UK

IMMUNOLOGY P1.149-N

Pathological mechanisms of antiphospholipid antibodies in trophoblastic cell fusion Tess Marchetti1,2, Philippe de Moerloose2, Marie Cohen0, 1 Laboratory of Hormonology, Geneva University Hospitals, Geneva, Switzerland, 2Haemostasis Unit, Geneva University Hospitals, Geneva, Switzerland

P1.150

Examining the effect of obesity-associated systemic inflammation on the uterine immune cell niche in early pregnancy Yoona Kim1, Sofie Perdu1, Mahroo Aghababaei1, Alexander Beristain1, 1 The University of British Columbia, Vancouver, Canada

P1.151

Phagocytic activity of macrophages is regulated by first trimester decidual cells in response to pro-inflammatory stimuli via the modulation of “Don’t-Eat-Me” signal Longzhu Piao1, Susheela Tridandapani2, S. Joseph Huang1, 1 Deartment of Ob/Gyn, The Ohio State University, Columbus, OH, USA, 2SBS-Microbial Infection/ Immunity, The Ohio State University, Columbus, OH, USA

P1.152

Pregnancy Recall in Decidual NK Cells Debra Goldman-Wohl1, Moriya Gamliel2, Ronit Gilad1, Tal Imbar1, Ronit Haimov-Kochman1, Caryn Greenfield1, Iris Eisenberg-Loebl1, Ofer Mandelboim2, Simcha Yagel1, 1 The Magda and Richard Hoffman Center for Human Placenta Research, Department of Obstetrics and Gynecology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel, 2Lautenberg Center for Immunology, Hebrew University Hadassah Medical School, Jerusalem, Israel

P1.153-N

Cytokines prolife in maternal and cord blood of diabetic mothers Glilciane Morceli1, Cristiane Hara2, Adenilda Honório-França2, Eduardo França2, Danny Laura Fagundes1, Marilza Rudge1, Débora Damasceno1, Iracema Calderon1, 1 Botucatu Medical School, Botucatu/São Paulo, Brazil, 2Institute of Biological and Health Science Federal University of Mato Grosso, Barra do Garças/Mato Grosso, Brazil

P1.154

Immune system and reproductive success: the genetics of the maternal-fetal interface Olympe Chazara1, Annettee Nakimuli2, Lydia Farrell1, Susan Hiby1, Hugo Hilton3, Paul Norman3, Neda Nemat-Gorgani3, Alison Eliott4,5, Pontiano Kaleebu4, Florence Mirembe2, Peter Parham3, Ashley Moffett1, 1 University of Cambridge, Cambridge, UK, 2Makerere University, Kampala, Uganda, 3Stanford University School of Medicine, Stanford, USA, 4Medical Research Council/Uganda Virus Research Institute, Entebbe, Uganda, 5London School of Hygiene and Tropical Medicine, London, UK


57

P1.155-N

Uptake of macrophage exosomes by the human placenta. Beth Holder1, Tessa Jones1, Sandra Okala1, Karen Forbes2, Beate Kampmann1, 1 Imperial College, London, UK, 2The University of Manchester, Manchester, UK

P1.156

Not submitted Eun Lee1, Samone Franzese1, DaShaunda Hilliard2, Maria Teves1, Ronald Ramus1, Jerome Strauss1, 1 Virginia Commonwealth University, Richmond, Virginia, USA, 2Eastern Virginia Medical School, Norfolk, Virginia, USA

P1.157-N

Reduced placental development triggered by subcutaneous injection of an orally tolerated protein Daniel Galdino1, Geraldo Azevedo1, Kênia Souza1, Thiago Cantarutti1, Estela Bevilacqua2, Nelson Vaz1, Claudia Carvalho1, 1 Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil, 2Universidade de São Paulo, São Paulo, Brazil

P1.158

Systemic maternal immunity differs throughout gestation based on fetal sex Douglas Creedon1, Elizabeth Ann Enninga1, Wendy Nevala1, Svetomir Markovic1, Shernan Holtan2, 1 Mayo Clinic, Rochester, MN, USA, 2University of Minnesota, Minneapolis, MN, USA

P1.159

Human dNK and regulatory T cells communication in the fetal-maternal interface: a cellular identity and explanation of preeclampsia Jianhong Zhang1, Caroline E. Dunk1,2, Rebecca L. Jones3,4, Lynda K. Harris3,4, Sarah Keating5, Stephen J. Lye1,2, Stephen J. Lye6, 1 2 Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada, Departments of 3 Obstetrics & Gynecology, University of Toronto, Toronto, Canada, Institute of Human Development, University of Manchester, Manchester, UK, 4St. Mary’s Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK, 5 Departments of Pathology, University of Toronto, Toronto, Canada, 6Departments of Physiology, University of Toronto, Toronto, Canada

P1.160

Spatiotemporal expression patterns of macrophage migration inhibitory factor (MIF) and its receptor CD74 in mink placenta Vibeke Dantzer1, Christiane Pfarrer2, luana Paulesu3, Francesca Ietta3, 1 Copenhagen university, Frederiksberg C, Denmark, 2University of Veterinary Medicin Hannover, Hannover, Germany, 3University of Sienna, Sienna, Italy

P1.161-N

Expression of MHC class I in normal and cloned bovine placenta Rodrigo da Silva Nunes Barreto1, Ana Carolina Furlanetto Mançanares1, Flávia Thomaz Verechia3, Felipe Perecin2, Flávio Vieira Meirelles2, Lilian de Jesus Oliveira1, 1Faculdade de Medicina Veterinária e Zootecnia - Universidade de São Paulo, São Paulo/SP, Brazil, 2 Faculdade de Zootecnia e Engenharia de Alimentos - Universidade de São Paulo, Pirassununga/SP, Brazil, 3Faculdade de Zootecnia - Universidade Estadual Paulista “Júlio de Mesquit Filho”, Dracena/ SP, Brazil

P1.162-N

Deviations of endometrial immune cells during pregnancy in the cow Ana Carolina Furlanetto Mançanares1, Rodrigo da Silva Nunes Barreto1, Naira Caroline Godoy Pieri1, Aline Fernanda de Souza1, Carlos Eduardo Ambrosio2, Flavio Vieira Meirelles2, Daniele dos Santos Martins2, Lilian de Jesus Olivera1, 1 Faculdade de Medicina Veterinária e Zootecnia - Universidade de São Paulo, São Paulo, SP, Brazil, 2 Faculdade de Zootecnia e Engenharia de Alimentos - Universidade de São Paulo, Pirassununga, SP, Brazil

IMPLANTATION P1.163

Targeting placental leukemia inhibitory factor in vivo with a unique inhibitor as a novel treatment strategy for ectopic pregnancy. Amy Winship1,5, Tara Trishnan1,5, Ellen Menkhorst1,5, Andrew Horne3, Jeremy Brown3, Stephen Tong4, Jian-Guo Zhang2, Nick Nicola2, Eva Dimitriadis1,5, 1 MIMR-PHI Institute of Medical Research, Melbourne, Australia, 2The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia, 3The University of Edinburgh, Edinburgh, UK, 4The University of Melbourne, Melbourne, Australia, 5Monash University, Melbourne, Australia


58

POSTER SESSION 2 - Thursday 11th september 2014 INFECTION P2.1

Congenital infection of protozoa: Histopathological and histochemical analysis of human chorionic villi explants infected ex vivo with Trypanosoma cruzi and Toxoplasma gondii Ana Liempi1, Daniel Droguett1,2, Christian Castillo1, Alexandra Sandoval1, Priscilla Figueroa1, Norbel Galanti1, Juan Diego Maya1, Ulrike Kemmerling1, 1 Universidad de Chile, Santiago de Chile, Región Metropolitana, Chile, 2Universidad de Talca, Talca, VII Región, Chile

P2.2

Inhibition of placental mTORC1 signalling may explain decreased placental nutrient transport and contribute to restricted fetal growth in placental malaria Genelyn Dimasuay1, Jocelyn Glazier3, Stephen Rogerson1,2, Thomas Jansson4, Philippe Boeuf1,2, 1 The University of Melbourne, Melbourne, Australia, 2Victorian Infectious Diseases Service, Melbourne, Australia, 3University of Manchester, Manchester, UK, 4University of Texas Health and Science Center at San Antonio, San Antonio, TX, USA

P2.3

Placental hepatitis b virus infection and obstetric outcome Terence Lao1, Man-Kin Chung1, Theresa Cheung1, Tak-Sun Lau1, Vincent Wong2, Henry Chan2, Tak Yeung Leung1, 1 Department of Obstetrics & Gynaecology, The Chinese University of Hong Kong, Shatin, Hong Kong, 2 Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong

P2.4-N

Salmonella enterica serovar Typhimurium productively infects human primary trophoblast cells and induces inflammatory cell death Tina Nguyen1,2, Ian Perry3, Shawn Murphy3, Andree Gruslin1, Lakshmi Krishnan1,2, 1 University of Ottawa, Ottawa, Ontario, Canada, 2National Research Council of Canada, Ottawa, Ontario, Canada, 3University of Rochester, Rochester, New York, USA

P2.5

Induction of an Innate Immune Response and Pathogenesis Following Ex Vivo Infection of Human Decidual Tissues with Human Cytomegalovirus Simcha Yagel1, Yiska Weisbloom2,3, Amos Panet3, Zichria Zakay-Rones3, Ronit Haimove-Kochman1, Debra Goldman-Wohl1, Caryn Greenfield1, Dana Wolf2, 1 Obstetrics and Gynecology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel, 2 Clinical Virology Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel, 3Department of Biochemistry and the Chanock center for Virology, IMRIC, Hadassah Hebrew University Medical Center, Jerusalem, Israel

P2.6-N

Pyrosequencing of bacterial 16S ribosomal RNA demonstrates distinct microbiome profiles of placenta and maternal blood in women with preterm ruptured membranes who develop chorioamnionitis, compared to those who do not become infected. Owen Stock1,2, Stephen Tong1,2, Natalie Hannan1, Lavinia Gordon0, 1 The University of Melbourne, Heidelberg, Victoria, Australia, 2Mercy Hospital for Women, Heidelberg, Victoria, Australia, 3Murdoch Children’s Research Institute, Parkville, Victoria, Australia

P2.7

13-HODE is the major PPARg ligand secreted by human cytotrophoblasts upon infection by HCMV Kaoutar Leghmari2, Nicolas Cénac2, Benjamin Rauwel2, Hélène Martin2, Justine Bertrand-Michel3, Pauline Le Faouder3, Christian Davrinche2, Thierry Fournier1, Stéphane Chavanas2, 1 UMR-S 1139, INSERM, University of Paris Descartes, Paris, France, 2UMR 1043, INSERM, CNRS, UPS, Toulouse, France, 3I2MC INSERM U1048, Toulouse, France


59

P2.8

Placental infection by Salmonella enterica Typhimurium in a murine model: mechanisms of pathogenesis and role of inflammatory cell death Kristina Wachholz1,2, Gerard Agbayani1,2, Tina Nguyen1,2, Komal Gurnani2, Lakshmi Krishnan1,2, 1 University of Ottawa, Ottawa, Ontario, Canada, 2National Research Council of Canada, Ottawa, Ontario, Canada

P2.9

How The Placenta Makes Pregnant Women Vulnerable to Influenza (Flu) Jorge M. Tolosa1, Kristy Parsons2, Peter Wark2, Roger Smith1, 1Mothers and Babies Research Centre. The University of Newcastle and Hunter Medical Research Institute (HMRI), Newcastle, NSW, Australia, 2Respiratory Medicine. The University of Newcastle and Hunter Medical Research Institute (HMRI), Newcastle, NSW, Australia

P2.10

Identification of the Placental Inflammatory Cytokine Transcriptional Signature Associated with Congenital CMV Infection Mark Schleiss1, Peter Gillis1, 1 University of Minnesota Medical School, Division of Pediatric Infectious Diseases, Minneapolis, MN, USA

INFLAMMATION P2.11

The enzymes regulating endothelin-1 in chorioamnionitis Tomomi Kotani1, Yukio Mano1, Tomoko Nakano1, Hiroyuki Tsuda1, Seiji Sumigama1, Hua Li1, Kaoru Nimi1, Fumitaka Kikkawa1, 1 Nagoya University of graduate school of medicine, Nagoya, Japan

P2.12-N

Paraoxonase 3 expression is spatially down-regulated in the human placenta in labour Samy Alwarfaly1, Akrem Abdulsid1, Fiona Lyall1, 1 University of Glasgow, Medical Genetics Institution, Glasgow, UK

INVASION P2.13

PreImplantation Factor (PIF) Promotes Human Trophoblast Invasion Hadia Moindjie1, Esther Dos Santos1,2, Laurence Loeuillet4, Héloise Gronier1, Philippe De Mazancourt1,3, Eytan R Barnea6,7, François Vialard1,5, Marie-Noelle Dieudonne1, 1 Université Versailles St Quentin en Yvelines, Montigny le Bretonneux 78180, France, 2Service 3 de Biologie Médicale CHI Poissy-St Germain, Poissy 78300, France, Service de Biochimie et 4 Génétique Moléculaire Hôpital A.Paré, Boulogne 92100, France, Service d’Anatomo-pathologie, Centre Hospitalier de Poissy-Saint Germain, Poissy 78300, France, 5Département de Biologie de la Reproduction, Cytogénétique, Gynécologie et Obstétrique, Centre Hospitalier de Poissy-Saint Germain, Poissy 78300, France, 6Society for the Investigation of Early Pregnancy, Cherry Hill NJ, USA, 7 BioIncept, LLC,, Cherry Hill NJ, USA

P2.14

Genome variation in the trophoblast of different mammalian species: diploidy, polyteny, depolytenization, genome segregation Tatiana Zybina1, Grigory Stein1, Pozharisski Kazimir2, Eugenia Zybina1, 1 Institute of Cytology RAS, St.-Petersburg, Russia, Russia, 2Russian Research Centre for Radiology and Surgical Technologies, St.-Petersburg, Russia, Russia

P2.15

A Role for SIRT1 in the Regulation of Trophblast Invasion Christopher Mansour1, Jeremiah Gaudet1, Shannon Bainbridge1,2, 1Interdisciplinary School of Health Sciences, Faculty of Health Sciences, University of Ottawa, Ottawa, Canada, 2Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Canada

P2.16-N

Placenta-specific miRNA miR-520c modulates CD44-mediated extravillous trophoblast cell invasion Hironori Takahashi1,2, Akihide Ohkuchi1, Takami Takizawa2, Shigeki Matsubara1, Rie Usui1, Tomoyuki Kuwata1, Mitsuaki Suzuki1, Toshihiro Takizawa2, 1 Jichi Medical University, Tochigi, Japan, 2Nippon Medical School, Tokyo, Japan

P2.17

FoxO1 Transcription Factor Promotes Integrin β3 Expression in Trophoblasts Chie-Pein Chen1,2, Yi-Hsin Wu2, Hungwen Chen3, 1Division of High Risk Pregnancy, Mackay Memorial Hospital, Taipei, Taiwan, 2Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan, 3Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan


60

P2.18-N

Changes in extravillous trophoblast (EVT) gene expression in cases of abnormally invasive placenta support an enhanced epithelial-to-mesenchymal transition Sonia DaSilva-Arnold1, Stacy Zamudio1, Abdulla Al-Khan1, Nicholas Illsley1, 1 Hackensack University Medical Center, Hackensack, NJ, USA

P2.19-N

Developing a quantitative scoring system to assess the ‘clinical severity’ of the abnormally invasive placenta (AIP) Sally Collins1,2, Stacey Zamudio3, Nicholas Illsley3, Abdulla Al-Khan3, Lawrence Impey2, 1 University of Oxford, Oxford, UK, 2John Radcliffe Hospital, Oxford, UK, 3Hackensack University Medical Center, Hackensack, USA

METABOLISM P2.20-N

Antiphospholipid antibodies alter cell-death-regulating lipid metabolites in first and third trimester human placentae Priyadarshini Pantham2,1, Alexander Heazell3, Graham Mullard3, Paul Begley3, Qi Chen1, Maria Brown3, Warwick Dunn4,3, Larry Chamley1, 1 The University of Auckland, Auckland, New Zealand, 2University of Texas Health Science Centre San Antonio, San Antonio, TX, USA, 3University of Manchester, Manchester, UK, 4University of Birmingham, Birmingham, UK

P2.21-N

Birthweight -BMI or glucose. A human in vivo study. Ane Moe Holme1, Trond M Michelsen1, Maia Blomhoff Holm1, Gun Lisbet Opheim1, Guttorm Haugen1,2, Tore Henriksen1,2, 1 Oslo University Hospital, Department of Obstetrics, Oslo, Norway, 2University of Oslo, Oslo, Norway

P2.22

A novel energy source for the feto-placental unit - creatine Hayley Dickinson1,2, Stacey Ellery1,2, Paul Della Gatta3, Lobna Ghattas3, Syed Baharom1,2, Miranda Davies-Tuck1,2, Euan Wallace1,2, Joanne Mockler1, Rod Snow3, David Walker1,2, 1 The Ritchie Centre, MIMR-PHI Institute of Medical Research, Victoria, Australia, 2Department of Obstetrics & Gynaecology, Monash University, Victoria, Australia, 3Centre for Physical Activity and Nutrition, Deakin University, Victoria, Australia

P2.23

Expression and localization of the tryptophan-degrading enzymes tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase-2 in the human placenta Liudmila Nikitina1, Astrid Blaschitz1, Martin Gauster1, Carolin Besenböck1, Christian Wadsack1, Gernot Desoye1, Peter Sedlmayr1, 1 Medical University of Graz, Graz, Austria

P2.24

The role of placental carbonyl-reducing enzymes in biotransformation of bupropion and 4-methylnitrozamino-1-(3-pyridyl)-1-butanone (NNK). Valentina Fokina1, Mahmoud Ahmed1, Tatiana Nanovskaya1, 1 University of Texas Medical Branch, Galveston, Texas, USA

P2.25-N

Determination of trace elements and their distribution maps in bovine placenta Sonia Will1, Phelipe Favaron1, Maria Angelica Miglino1, Rose Eli Rici1, Andrea Pereira1, 1 University of São Paulo, São Paulo, SP, Brazil

P2.26

Preterm fetal cortisol overexposure alters placental glucose delivery nearer term Owen Vaughan1, Abigail Fowden1, 1University of Cambridge, Cambridge, UK

P2.27-N

A diet high in sugar and fat alters the insulin signalling in the mouse placenta. Barbara Musial1, Owen Vaughan1, Amanda Sferruzzi-Perri1, Abigail Fowden1, 1 University of Cambridge, Cambridge, UK

P2.28

Docosahexaenoic acid supplementation in pregnancy alters placental fatty acid composition Theresa L Powell1, Christiane Meireles1, Vanessa I Ramirez1, Evelyn Miller1, Kevin W Hakala2, Susan T Weintraub2, Susanne Lager1, 1Dept Obstetrics and Gynecology, University of Texas Health Science Center San Antonio, San Antonio, Texas, USA, 2Dept Biochemistry University of Texas Health Science Center San Antonio, San Antonio, Texas, USA


61

OXIDATIVE STRESS P2.29

Curcumin induces the expression of heme-oxygenase-1 in human placental explants. ainslie garrod1, susan greenwood1, colin sibley1, elizabeth cottrell1, 1 Maternal and Fetal Health Research Centre, The University of Manchester,, manchester, UK

P2.30

Immunohistochemical localization of bilirubin oxidation in human placenta Michiko Suzuki1, Rie Kawaguchi1, Takashi Nikaido2, Tadao Tanaka1, Aikou Okamoto1, 1 The Jikei University, School of Medicine, Tokyo, Japan, 2Kosei General hospital, Tokyo, Japan

P2.31-N

Free ferrous iron in amniotic fluid as a predictive marker of fetal disorders in pregnancy Yuka Hattori1,2, Tomomi Kotani1, Tomoko Nakano1, Yukio Mano1, Seiji Sumigama1, Hiroyuki Tsuda1, Takafumi Usida3, Hideko Nagasawa3, Shinya Toyokuni2, Fumitaka Kikkawa1, 1Department of Gynecology and Obstetrics, Nagoya University Graduate school of medicine, Nagoya, Japan, 2Department of Pathology and Biological Responases, Nagoya University Graduate school of Medicine, Nagoya, Japan, 3Labolatory of Pharmaceutical and Medical Chemistry, Gifu Pharmaceutical University, Gifu, Japan

P2.32

Maternal obesity is associated with an altered antioxidant system in the umbilical artery endothelium: new insights into vascular fetal programming by maternal obesity? Ivo Carrasco1,2, Omar Porras3, Paola Casanello1,2, 1 Division of Obstetric & Gynecology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile, 2Division of Pediatrics, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile, 3Institute of Nutrition and Food Technology, Universidad de Chile, Santiago, Chile

P2.33-N

Heat shock transcription factor 1 expression is spatially distributed and selectively downregulated in the human placenta during labour. Akrem Abdulsid1, Fiona Lyall1, 1 University of Glasgow, Medical Genetics Institution, Glasgow, UK

PLACENTAL DYSFUNCTION P2.34-N

Pena-Shokeir Phenotype/ Fetal Akinesia Deformation Sequence: From Placenta to Secondary Myopathy Dehua Wang1, Robert J Hopkin2, Emily King2, Maria A Calvo-Garcia3, Jerzy Stanek1, 1 Division of Pathology and Laboratory Medicine, Cincinnati Children’s Hospital, Cincinnati, Ohio, USA, 2 Division of Medical Genetics, Cincinnati Children’s Hospital, Cincinnati, Ohio, USA, 3Department of Radiology, Cincinnati Children’s Hospital, Cincinnati, Ohio, USA

P2.35

Diabetes affects rat placental morphology and pregnancy Priscilla Farias1, Karine Souza1, Emerson Fioretto1, Marcio Santos1, Marlúcia Aires1, 1 Federal University of Sergipe, São Cristovao, Sergipe, Brazil

P2.36

Nucleated Red Blood Cells Count in Pregnancies with Idiopathic Intra-Uterine Growth Restriction Fatemeh Davaritanha1, Mahbod Kaveh1, 1 Tehran University of Medical Sciences, Tehran, Iran

P2.37

Preterm placental calcification is a major risk factor of late-onset intrauterine fetal death: An experience of over 20,000 pregnancies Kuo-Hu Chen1,2, Li-Ru Chen3, 1 Department of Obstetrics and Gynecology, Taipei Tzu-Chi Hospital, The Buddhist Tzu-Chi Medical Foundation, Taipei, Taiwan, 2School of Medicine, Tzu-Chi University, Hualien, Taiwan, 3Mackay Memorial Hospital, Taipei, Taiwan

P2.38-N

The Role of VEGF165b in Trophblast Survival - Implications for Pre-eclampsia Pathophysiology Victoria Bills1,2, Peter Soothill1, Dave Bates2, 1 St Michael’s Hospital, University Hospitals Bristol, Bristol, UK, 2University of Bristol, Bristol, UK

P2.39-N

Altered expression of placental microRNAs in folate deficient teenage mothers Bernadette Baker1, Susan Greenwood1, Karen Forbes1, Alexander Heazell1, Rebecca Jones1, 1 University of Manchester, Manchester, UK


62

P2.40

Central Placenta Processing to Optimize Multicenter Collection, Analysis, and Storage of Human Placental Tissue in the National Children’s Study (NCS) Philip J. Katzman1, Carolyn Salafia2, Luis Ruffolo1, Amulya Penmetsa1, Christopher J. Stodgell1, Jack Moye3, Barbara O’Brien4, Richard K. Miller1, 1 University of Rochester School of Medicine and Dentistry, Rochester, NY, USA, 2Placenta Analytics, LLP, Larchmont, NY, USA, 3National Children’s Study, National Institues of Health, Bethesday, MD, USA, 4Westat, Bethesda, MD, USA

P2.41

The Small Placenta at Term: Who Are The Babies With Placental Weight 20 SA

Aide au Diagnostic Patientes symptomatiques > 20 SA

inDicAtions

Présence de facteurs de risque

Facteurs de risque + / - signes d’alerte (céphalées, troubles visuels, douleurs abdominales…)

Signes cliniques Facteurs de risques Tableau douteux

BioMARQUEURs

• PAPP-A • PLGF

• Ratio SFLT-1/PLGF

• PLGF • ou ratio /PLGF

* PAPP-A = Protéine Plasmatique Placentaire A * PlGF = Placental Growth Factor * sFlt-1 = Fraction soluble du récepteur VEGF-R1 (fms-like tyrosine kinase 1) a Indication actuellement hors Fiche Technique Cobas® b Indication en cours de développement

1. 2. 3. 4. 5.

Rana S et al. Angiogenic Factors and the Risk of Adverse Outcomes in Women with Suspected Preeclampsia Circulation 2012;125(7):911-9 Wang, A., et al. Preeclampsia: The Role of Angiogenic Factors in Its Pathogenesis. Physiology. 2009; 24, 147-158 Akolekar R., et al. Competing Risks Model in Early Screening for Preeclampsia by Biophysical and Biochemical Markers. Fetal Diagn Ther 2013;33:8-15 Hagmann H, et al. The Promise of Angiogenic Markers for the Early Diagnosis and Prediction of Preeclampsia Clin Chem. 2012;58(5), 837-45. Verlohren S et al. An automated method for the determination of the sFlt-1/PIGF ratio in the assessment of preeclampsia Am J Obstes Gynecol 2010;202:161.e1-11

Les tests Elecsys PlGF , Elecsys PAPP-A, Elecsys sFlt-1 sont des tests immunologiques pour la détermination quantitative de la protéine plasmatique placentaire A (PAPP-A), du facteur de croissance placentaire (PlGF), et de la fms-like tyrosine kinase-1 soluble (sFlt-1) dans le sérum humain. Ces tests par électrochimiluminescence « ECLIA » s’utilisent sur les analyseurs Elecsys et cobas e. Les tests Elecsys sFlt-1 et PlGF s’utilisent en association dans le diagnostic de prééclampsie et d’autres informations cliniques et diagnostiques. Le test Elecsys PAPP-A s’utilise en association avec d’autres paramètres pour évaluer le risque de trisomie 21 (syndrome de Down) au cours du premier trimestre de la grossesse. Pour le diagnostic d’aberrations chromosomiques, le recours à d’autres analyses est nécessaire. Dispositifs médicaux de diagnostic in vitro. Le test Elecsys PAPP-A figure à l’annexe II liste B – CE 0123 (TÜV SÜD) Fabricant : Roche Diagnostics GmbH (Allemagne) – Distributeur : Roche Diagnostics France Lire attentivement les instructions figurant dans les fiches techniques 08/2014 – PA-195-14

*Apportons des solutions à nos patients

Dépistage a Patientes à risque < 16 SA

5295 - Pro(G

Les biomarqueurs PAPP-A*, PlGF * et sFlt-1* permettent d’évaluer l’altération placentaire de façon plus précoce et plus spécifique que les signes cliniques de pré-éclampsie (PE). 2 Ces marqueurs permettent : l Dépistage des patientes à risque de PE. 3 l Prédictif de PE : anticiper la survenue de PE afin de prévenir les complications materno-fœtales et adapter la prise en charge. 1, 4, 5 l Aide au diagnostic de PE : soutien du clinicien dans sa prise de décision. 5

program - Le Public SystÃ¨me

program - Le Public SystÃ¨me

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