Atherosclerotic cardiovascular diseases (ASCVD) are a ... As part of the Systems Approach to Biomarker Research in ... pressure, total cholesterol, and body mass index were higher, .... *Matching factors. ... marker model (based on each of 20 imputed data sets) was .... affected by other markers in the same model.
Protein Biomarkers of New-Onset Cardiovascular Disease Prospective Study From the Systems Approach to Biomarker Research in Cardiovascular Disease Initiative Xiaoyan Yin, Subha Subramanian, Shih-Jen Hwang, Christopher J. O’Donnell, Caroline S. Fox, Paul Courchesne, Pieter Muntendam, Neal Gordon, Aram Adourian, Peter Juhasz, Martin G. Larson, Daniel Levy Objective—Incorporation of novel plasma protein biomarkers may improve current models for prediction of atherosclerotic cardiovascular disease (ASCVD) risk. Approach and Results—We used discovery mass spectrometry (MS) to determine plasma concentrations of 861 proteins in 135 myocardial infarction (MI) cases and 135 matched controls. Then, we measured 59 markers by targeted MS in 336 ASCVD case–control pairs. Associations with MI or ASCVD were tested in single-marker and multiple-marker analyses adjusted for established ASCVD risk factors.Twelve single markers from discovery MS were associated with MI incidence (at P
