tance < 400 m, were able to exercise on a treadmill, had no pre- vious vascular or ... standard treadmill test (Treadmill Proform, Icon Health & Fit- ness, Logan ... Inc, Greenwich, CT, USA) (CV=7%), D-dimer, vWF and sTM. (Asserachroms,.
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Cardiovascular Biology and Cell Signalling
Prothrombotic activity is associated with the anatomical as well as the functional severity of peripheral arterial occlusive disease Marthe Nylænde1, Andries Kroese1, Einar Stranden2, Britt Morken2, Gunnar Sandbæk3, Anne Karin Lindahl1, Harald Arnesen4,5, Ingebjørg Seljeflot4,5 1
Department of Vascular Surgery, 2Department of Vascular Diagnosis and Research and 3Department of Radiology, Aker University Hospital, Oslo, Norway 4 Center for Clinical Research and 5Department of Cardiology, Ullevål University Hospital, Oslo, Norway
Summary The importance of prothrombotic activity in cardiovascular disease has been well established. However, limited data exist on the relationship between prothrombotic activity and the severity of peripheral arterial occlusive disease (PAD).The objective of the present study was to investigate the relationship between markers of haemostasis and the diagnostic measures of PAD: ankle-brachial-index (ABI), maximum treadmill walking distance and angiographic score.In a cross-sectional study of 127 patients (mean age 66 years; 64% males) with angiographically verified PAD, fasting blood samples were drawn, and citrated plasma was obtained for determination of selected haemostatic variables: von Willebrand factor (vWF), thrombomodulin (sTM), thrombin-antithrombin complex (TAT),soluble tissue factor (sTF),tPA antigen (tPAag) and D-dimer were all significantly correlated with the angiographic score (p
