Anthony K. C. Chan, MBBS, FRCPC, FRCPCH, FRCPath ..... Journal of
Biomedical Materials Research - Part A 80(1):216-225, 2007. 75. Patel S#, Berry
LR, ...
Publication List Anthony K. C. Chan, MBBS, FRCPC, FRCPCH, FRCPath PUBLICATIONS (Peer‐Reviewed): * corresponding author/Principal investigator # trainee under my supervision 1. Bingham WT, Chan A, Rennie R, Williams KE, Sankaran K. Neonatal campylobacter fetus meningitis: a report of an unusual case (letter). Clinical Pediatrics 31(4):255‐256, 1992. 2. Wong V, Cheng CH, Chan KC. Fetal and neonatal outcome of exposure to anticoagulants during pregnancy. American Journal of Medical Genetics 45(1):17‐21, 1993. 3. Chan AKC, Leaker M, Burrows FA, Williams WG, Gruenwald CE, Whyte L, Adams M, Brooker LA, Adams H, Mitchell L, Andrew M. Coagulation and fibrinolytic profile of paediatric patients undergoing cardiopulmonary bypass. Thrombosis and Haemostasis 77(2):270‐277, 1997. 4. Chan A, Berry L, O’Brodovich H, Klement P, Mitchell L, Baranowski B, Monagle P, Andrew M. Covalent antithrombin‐heparin complexes with high anticoagulant activity: Intravenous, subcutaneous and intratracheal administration. Journal of Biological Chemistry 272(35):22111‐22117, 1997. 5. Chan AKC, Berry L, Mitchell L, Baranowski B, O'Brodovich H, Andrew M. Effect of a novel covalent antithrombin‐heparin complex on thrombin generation on fetal distal lung epithelium. American Journal of Physiology‐Lung Cellular and Molecular Physiology 274:L914‐ L921, 1998. 6. Nitschmann E, Berry L, Bridge S, Dereske M, Richardson M, Monagle P, Chan A, Andrew M. Morphological and biochemical features affecting the antithrombotic properties of the inferior vena cava of rabbit pups and adult rabbits. Pediatric Research 43(1):62‐67, 1998. 7. Nitschmann E, Berry L, Bridge S, Hatton MWC, Richardson M, Monagle P, Chan AKC, Andrew M. Morphological and biochemical features affecting the antithrombotic properties of the aorta in adult rabbits and rabbit pups. Thrombosis and Haemostasis 79(5):1034‐1040, 1998. 8. Berry L, Chan AKC, Andrew M. Polypeptide‐polysaccharide conjugates produced by spontaneous non‐enzymatic glycation. Journal of Biochemistry 124(2):434‐439, 1998. 9. Chan AKC, Baranowski B, Berry L, Liu M, Rafii B, Post M, O'Brodovich H, Monagle P, Andrew M. Influence of mechanical stretch on thrombin regulation by fetal mixed lung cells. American Journal of Respiratory and Cellular and Molecular Biology 19(3):419‐425, 1998. 10. Chan AKC, Berry L, Klement P, Julian J, Mitchell L, Weitz J, Hirsh J, Andrew M. A novel antithrombin‐heparin covalent complex: Antithrombotic and bleeding studies in rabbits. Blood Coagulation and Fibrinolysis 9(7):587‐595, 1998.
11. Monagle P, Berry L, O’Brodovich H, Andrew M, and Chan A*. Covalent heparin cofactor II‐ heparin and heparin cofactor II‐dermatan sulfate complexes: Characterization of novel anticoagulants. Journal of Biological Chemistry 273(50):33566‐33571, 1998. 12. Berry L, Stafford A, Fredenburgh J, O’Brodovich H, Mitchell L, Weitz J, Andrew M, Chan AKC*. Investigation of the anticoagulant mechanisms of a covalent antithrombin‐heparin complex. Journal of Biological Chemistry 273(52):34730‐34736, 1998. 13. deVeber G, Monagle P, Chan A, MacGregor D, Curtis R, Lee S, Vegh P, Adams M, Marzinotto V, Leaker M, Massicotte MP, Lillicrap D, Andrew M. Prothrombotic disorders in infants and children with cerebral thromboembolism. Archives of Neurology 55(12):1539‐1543, 1998. 14. deVeber G, Chan A, Monagle P, Marzinotto V, Armstrong D, Massicotte P, Leaker M, Andrew M. Anticoagulation therapy in pediatric patients with sinovenous thrombosis: A cohort study. Archives of Neurology 55(12):1533‐1537, 1998. 15. Streif W#, Andrew M, Marzinotto V, Massicotte MP, Chan AKC, Julian J, Mitchell L. Analysis of warfarin therapy in pediatric patients: A prospective cohort study of 319 patients. Blood 94 (9):3007‐3014, 1999. 16. Dix D, Andrew M, Marzinotto V, Charpentier K, Bridge S, Monagle P, deVeber G, Leaker M, Chan AKC, Massicotte MP. The use of low molecular weight heparin in pediatric patients: a prospective cohort study. Journal of Pediatrics 136(4):439‐445, 2000. 17. Marzinotto V, Monagle P, Chan A, Adams M, Massicotte P, Leaker M, Andrew M. Capillary whole blood monitoring of oral anticoagulants in children in outpatient clinics and home setting. Pediatric Cardiology 21(4):347‐352, 2000. 18. Gruenwald C, deSouza V, Chan AKC, Andrew M. Whole blood heparin concentrations do not correlate with plasma antifactor Xa heparin concentrations in pediatric patients undergoing cardiopulmonary bypass. Perfusion 15(3):203‐209, 2000. 19. Streif W#, Paes B, Berry L, Andrew M, Andreasen RB, Chan AKC*. Influence of exogenous factor VIIa on thrombin generation in cord plasma of full‐term and pre‐term newborns. Blood Coagulation and Fibrinolysis 11(4):349‐357, 2000. 20. Wiernikowski J, Crowther M, Clase C, Ingram A, Andrew M, Chan AKC*. Stability and sterility of recombinant tissue plasminogen activator at ‐30ºC. (Letter) Lancet 355(9222):2221‐2222, 2000. 21. Choi M, Massicotte MP, Marzinotto V, Chan AKC, Holmes JL, Andrew M. The use of alteplase to restore patency of central venous lines in pediatric patients: A cohort study. Journal of Pediatrics 139(1):152‐156, 2001. 22. Askalan R, Laughlin S, Mayank S, Chan A, MacGregor D, Andrew M, Curtis R, Meaney B, deVeber G. Chickenpox and stroke in childhood: A study of frequency and causation. Stroke 32(6):1257‐1262, 2001.
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23. deVeber G, Chan A. Aspirin versus low‐molecular‐weight heparin for ischemic stroke in children: an unanswered question. (Letter) Stroke 33(8):1947‐8, 2002. 24. Klement P, Du YJ#, Berry L, Andrew M, Chan AKC*. Blood‐compatible biomaterials by surface coating with a novel antithrombin‐heparin covalent complex. Biomaterials 23(2):527‐535, 2002. 25. Crowther MA, Berry LR, Monagle PT, Chan AKC*. Mechanisms responsible for the failure of protamine to inactivate low‐molecular‐weight heparin. British Journal of Haematology 116(1):178‐186, 2002. 26. Cornelius RM, Archambault JG, Berry L, Chan AKC, Brash JL. Adsorption of proteins from infant and adult plasma to biomaterial surfaces. Journal of Biomedical Materials Research 60(4):622‐ 632, 2002. 27. Chan AKC, Berry LR, Monagle PT, Andrew M. Decreased concentrations of heparinoids are required to inhibit thrombin generation in plasma from newborns and children compared to plasma from adults due to reduced thrombin potential. Thrombosis and Haemostasis 87(4):606‐613, 2002. 28. Chan AKC, Rak J, Berry L, Liao P, Vlasin M, Weitz J, Klement P. Antithrombin‐heparin covalent complex: A possible alternative to heparin for arterial thrombosis prevention. Circulation 106(2):261‐265, 2002 29. Berry LR, Becker DL, Chan AKC*. Inhibition of fibrin‐bound thrombin by a covalent antithrombin‐heparin complex. Journal of Biochemistry 132(2):167‐176, 2002. 30. Paredes N, Xu L, Berry LR, Chan AKC*. The effects of chemotherapeutic agents on the regulation of thrombin on cell surfaces. British Journal of Haematology 120(2):315‐324, 2003. 31. Berry LR, Klement P, Andrew M, Chan AKC*. Effect of covalent serpin‐heparinoid complexes on plasma thrombin generation on fetal distal lung epithelium. American Journal of Respiratory Cell and Molecular Biology 28(2):150‐158, 2003. 32. Monagle P, Chan AKC, Albisetti M, Vegh P, Andrew M, Mitchell L. Fibrinolytic system in adolescents: Response to venous occlusion stress tests. Pediatric Research 53(2):333‐337, 2003. 33. Albisetti M#, Chan AKC, McCrindle BW, Wong D, Vegh P, Adams M, Dinyari M, Monagle P, Andrew M. Fibrinolytic response to venous occlusion is decreased in patients after Kawasaki disease. Blood Coagulation and Fibrinolysis 14(2):181‐186, 2003. 34. Streif W, Goebel G, Chan AKC, Massicotte MP. Use of low molecular mass heparin (enoxaparin) in newborn infants: A prospective cohort study of 62 patients. Archives of Disease in Childhood, Fetal Neonatal Edition 88(5):F365‐F370, 2003. 35. Revel‐Vilk S#, Chan A*, Bauman M, Massicotte P. Prothrombotic conditions in an unselected cohort of children with venous thromboembolic disease. Journal of Thrombosis and Haemostasis 1(5):915‐921, 2003.
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36. Walker IR, Sek JT, Almonte TM, Carruthers JB, Chan AKC, Pai MK, Thibault AA, Heddle NM. Developing a tracking system for coagulation factor concentrates in southern Ontario. Transfusion 43(5):556‐562, 2003. 37. Massicotte MP, Julian JA, Marzinotto V, Gent M, Shields K, Chan AK, Szechtman B, Kohne S, Shepherd S, Bacher P, Andrew M. Dose‐finding and pharmacokinetic profiles of prophylactic doses of a low molecular weight heparin (reviparin‐sodium) in pediatric patients. Thrombosis Research 109(2‐3):93‐99, 2003. 38. Massicotte P, Julian JA, Gent M, Shields K, Marzinotto V, Szechtman B, Chan AK, Andrew M: the PROTEKT Study Group. An open‐label randomized controlled trial of low molecular weight heparin for the prevention of the central venous line‐related thrombotic complications in children: the PROTEKT trial. Thrombosis Research 109(2‐3):101‐108, 2003. 39. Watson LM, Chan AKC, Berry LR, Li J, Sood SK, Dickhout JG, Xu L, Werstuck GH, Bajzar L, Klamut HJ, Austin RC. Overexpression of the 78‐kDa glucose‐regulated protein/immunoglobulin‐ binding protein (GRP78/BiP) inhibits tissue factor procoagulant activity. Journal of Biological Chemistry 278(19):17438‐17447, 2003. 40. Paredes N, Wang A, Berry LR, Smith LJ, Stafford AR, Weitz JI, and Chan AKC*. Mechanisms responsible for catalysis of the inhibition of factor Xa or thrombin by antithrombin using a covalent antithrombin‐heparin complex. Journal of Biological Chemistry 278(26):23398‐ 23409, 2003. 41. Chan AKC *, Berry LR, Paredes N, Parmar N. Isoform composition of antithrombin in a covalent antithrombin‐heparin complex. Biochemical and Biophysical Research Communication 309(4):986‐991, 2003. 42. Kuhle S, Koloshuk B, Marzinotto V, Bauman M, Massicotte P, Andrew M, Chan A, Abdolell M, Mitchell L. A cross‐sectional study evaluating post‐thrombotic syndrome in children. Thrombosis Research 111(4‐5):227‐233, 2003. 43. Lanthier S, Kirkham FJ, Mitchell LG, Laxer RM, Atenafu E, Male C, Prengler M, Domi T, Chan AKC, Liesner R, deVeber G. Increased anticardiolipin antibody IgG titers do not predict recurrent stroke or TIA in children. Neurology 62(2):194‐200, 2004. 44. Revel‐Vilk S#, Sharathkumar A, Massicotte P, Marzinotto V, Daneman A, Dix D, Chan A*. Natural history of arterial and venous thrombosis in children treated with low molecular weight heparin: A longitudinal study by ultrasound. Journal of Thrombosis and Haemostasis 2(1):42‐46, 2004. 45. Albisetti M#, Chan AKC, McCrindle BW, Wong D, Monagle P, Andrew M. Impaired fibrinolytic activity is present in children with dyslipidemias. Pediatric Research 55(4):576‐580, 2004. 46. Chan AKC*, Patel S, Male C, Berry LR, Mitchell LG. Activated protein C generation is greatly decreased in plasma from newborns compared to adults in the presence or absence of endothelium. Thrombosis and Haemostasis 91(2):238‐247, 2004.
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47. Parvez B, Parmar N, Chan AKC*. Trimming of peripherally inserted central venous catheters may increase the risk of thrombosis. (Letter) Thrombosis Research 113(2):175‐177, 2004. 48. Chan AKC*, Paredes N, Thong B, Chindemi P, Paes B, Berry LR, Monagle P. Binding of heparin to plasma proteins and endothelial surfaces is inhibited by covalent linkage to antithrombin. Thrombosis and Haemostasis 91(5):1009‐1018, 2004. 49. Kuhle S, Massicotte P, Andrew M, Chan A, Mitchell L. A case series of 72 neonates with renal vein thrombosis: Data from the 1‐800‐NO‐CLOTS registry. Thrombosis and Haemostasis 92(4):929‐933, 2004. 50. Kuhle S, Massicotte P, Chan A, Adams M, Abdolell M, deVeber G, Mitchell L. Systemic thromboembolism in children: Data from the 1‐800‐NO‐CLOTS Consultation Service. Thrombosis and Haemostasis 92(4):722‐728, 2004. 51. Walker I, Sigouin CS, Sek J, Almonte T, Carruthers J, Chan A, Heddle N. Comparing handheld computers and paper diaries for hemophilia home therapy: A randomized trial. Haemophilia 10(6):698‐704, 2004. 52. Monagle P, Chan A, Massicotte P, Chalmers E, Michelson AD. Antithrombotic therapy in children: The seventh ACCP conference on antithrombotic and thrombolytic therapy. Chest 126(3 Suppl):645S‐687S, 2004. 53. Parmar N, Berry LR, Paredes N, Chan AKC*. Effect of heparins on thrombin generation in hemophilic plasma supplemented with FVIII, FVIIa, or FEIBA. Clinical Laboratory 51(3‐4):157‐ 166, 2005. 54. Athale UH, Siciliano SA, Crowther M, Barr RD, Chan AKC. Thromboembolism in children with acute lymphoblastic leukemia treated on Dana‐Farber Cancer Institute protocols: Effect of age and risk stratification of disease. British Journal of Haematology 129(6):803‐810, 2005. 55. Du YJ#, Klement P, Berry LR, Tressel P, Chan AKC*. In vivo rabbit acute model tests of polyurethane catheters coated with a novel antithrombin‐heparin covalent complex. Thrombosis and Haemostasis 94(2):366‐372, 2005. 56. Kuhle S, Massicotte P, Dinyari M, Vegh P, Mitchell D, Marzinotto V, Chan A, Pieniaszek H, Mitchell LG. Dose‐finding and pharmacokinetics of therapeutic doses of tinzaparin in pediatric patients with thromboembolic events. Thrombosis and Haemostasis 94(6):1164‐ 1171, 2005. 57. Ignjatovic V, Furmedge J, Newall F, Chan A, Berry L, Fong C, Cheng K, Monagle P. Age‐related differences in heparin response. Thrombosis Research 118(6):741‐745, 2006. 58. Rafay MF, Armstrong D, deVeber G, Domi T, Chan A, MacGregor DL. Craniocervical arterial dissection in children: clinical and radiographic presentation and outcome. Journal of Child Neurology 21(1):8‐16, 2006. 59. Kuhle S, Mitchell L, Andrew M, Chan AKC, Massicotte MP, Adams M, deVeber G. Urgent clinical challenges in children with ischemic stroke: Analysis of 1065 patients from the 1‐800‐
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NOCLOTS pediatric stroke telephone consultation service. Stroke 37(1):116‐122, 2006. 60. Monagle P, Barnes C, Ignjatovic V, Furmedge J, Newall F, Chan A, De Rosa L, Hamilton S, Ragg P, Robinson S, Auldist A, Crock C, Roy N, Rowlands S. Developmental haemostasis. Impact for clinical haemostasis laboratories. Thrombosis and Haemostasis 95(2):362‐372, 2006. 61. Arnold DM, Fergusson DA, Chan AKC, Cook RJ, Fraser GA, Lim W, Blajchman MA, Cook DJ. Avoiding transfusions in children undergoing cardiac surgery: A meta‐analysis of randomized trials of aprotinin. Anesthesia and Analgesia 102(3):731‐737, 2006. 62. Chan A, Jayasuriya K, Berry L, Roth‐Kleiner M, Post M, Belik J. Volutrauma activates the clotting cascade in the newborn but not adult rat. American Journal of Physiology: Lung Cellular and Molecular Physiology 290(4):L754‐L760, 2006. 63. Parmar N, Mitchell LG, Berry LR, Andrew M, Chan AKC*. The influence of age on in vitro plasmin generation in the presence of fibrin monomer. Acta Haematologica 115(3‐4):141‐51, 2006. 64. Brandao LR, Williams S, Kahr WHA, Clodagh R, Temple M, Chan AKC. Exercise‐induced deep vein thrombosis of upper extremity. 2. Case series in children. Acta Haematologica 115(3‐ 4):221‐229, 2006. 65. Chindemi PA, Klement P, Konecny P, Berry LR, Chan AKC*. Biodistribution of covalent antithrombin‐heparin complexes. Thrombosis and Haemostasis 95(4):629‐636, 2006. 66. Klement P, Du YJ, Berry LR, Tressel P, Chan AKC*. Chronic performance of polyurethane catheters covalently coated with ATH complex: A rabbit jugular vein model. Biomaterials 27(29):5107‐5117, 2006. 67. Mewhort‐Buist TA, Junop M, Berry LR, Chindemi P, Chan AKC*. Structural effects of a covalent linkage between antithrombin and heparin: Covalent N‐terminus attachment of heparin enhances the maintenance of antithrombin’s activated state. Journal of Biochemistry (Tokyo) 140:175‐184, 2006. 68. Berry LR, Parmar N, Hatton MWC, Chan AKC*. Selective cleavage of heparin using aqueous 2‐ hydroxypyridine: Production of an aldose‐terminating fragment with high anticoagulant activity. Biophysical Biochemical Research Communications 346(3):946‐957, 2006. 69. Athale U, Cox S, Siciliano S, Chan AKC. Thromboembolism in children with sarcoma. Pediatric Blood and Cancer, 49(2):171‐176, 2007. 70. Ignjatovic V, Summerhayes R, Gan A, Than J, Chan A, Cochrane A, Bennett M, Horton S, Shann F, Lane G, Ross‐Smith M, Monagle P. Monitoring unfractionated heparin (UFH) therapy: Which anti factor Xa assay is appropriate? Thrombosis Research, 120(3):347‐351, 2007. 71. Wiernikowski JT, Chan A*, Lo G. Reversal of anti‐thrombin activity using protamine sulfate. Experience in a neonate with a 10‐fold overdose of enoxaparin. Thrombosis Research, 120(2):303‐305, 2007.
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72. Lau A, Berry LR, Mitchell LG, Chan AKC*. Effect of substrate and fibrin polymerization inhibitor on determination of plasma thrombin generation in vitro. Thrombosis Research 119(6):667‐677, 2007. 73. Belletrutti M, Ali K, Barnard D, Blanchette V, Chan A, David M, Luke B, Price V, Ritchie B, Wu J, on behalf of the Canadian Pediatric Thrombosis and Hemostasis Network. Chronic immune thrombocytopenic purpura in children. A survey of the Canadian experience. Journal of Pediatric Hematology/Oncology 29(2):95‐100, 2007. 74. Du YJ, Brash JL, McClung G, Berry LR, Klement P, Chan AKC*. Protein adsorption on polyurethane catheters modified with a novel antithrombin‐heparin covalent complex. Journal of Biomedical Materials Research ‐ Part A 80(1):216‐225, 2007. 75. Patel S#, Berry LR, Chan AKC*. Analysis of inhibition rate enhancement by covalent linkage of antithrombin to heparin as a potential predictor of reaction mechanism. Journal of Biochemistry (Tokyo) 141(1):25‐35, 2007. 76. Klaassen RJ, Blanchette VS, Barnard D, Wakefield CD, Curtis C, Bradley CS, Neufeld EJ, Buchanan GR, Silva MP, Chan AKC, Young NL. Validity, reliability, and responsiveness of a new measure of health‐related quality of life in children with immune thrombocytopenic purpura: The kids’ ITP tools. Journal of Pediatrics 150(5):510‐515, 2007. 77. Gupta A, Wiernikowski JT, Chan AKC. The use of low molecular weight heparins in pediatrics: Two cases that highlight potential risks to patient safety. (Letter) Thrombosis Research, 121(2):281‐282, 2007. 78. Arnold DM, Webert KE, Carruthers J, Almonte T, Decker K, Seroski W, Reed J, Chan AKC, Pai M, Walker I. Trends in the utilization and wastage of coagulation factor concentrates: The application of a regional tracking programme. Haemophilia 13(3):271‐278, 2007. 79. Malowany JI, Knoppert DC, Chan AKC, Pepelassis D, Lee DSC. Enoxaparin use in the neonatal intensive care unit: Experience over 8 years. Pharmacotherapy, 27(9):1263‐1271, 2007. 80. Webert KE, Arnold DM, Carruthers J, Molnar L, Almonte T, Decker K, Seroski W, Reed J, Chan AK, Pai M, Walker IR. Utilization of recombinant activated factor VII in southern Ontario in 85 patients with and without haemophilia. Haemophilia, 13(5):518‐526, 2007. 81. Jegatheeswaran A, Parmar N, Walton JM, Yip C, Chan AKC*. Quantitative analysis of catheter roughness induced by cutting and manipulation: A potential prothrombotic risk. Blood Coagulation and Fibrinolysis, 18(6):531‐536, 2007. 82. Chan AKC, Black L, Ing C, Brandão LR, Williams S. Utility of aPTT monitoring unfractionated heparin in children. (Letter) Thrombosis Research, 122(1):135‐136, 2008. 83. Bassler D, Greinacher A, Okascharoen C, Klenner A, Ditomasso J, Kiefel V, Chan A, Paes B. A systematic review of the management of unexpected neonatal alloimmune thrombocytopenia. Transfusion, 48(1):92‐98, 2008. 84. Mewhort‐Buist TA, Liaw PC, Patel S, Atkinson HM, Berry LR, Chan AKC*. Treatment of
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endothelium with the chemotherapy agent vincristine affects activated protein C generation to a greater degree in newborn plasma than in adult plasma. Thrombosis Research, 122(3):418‐426, 2008. 85. Athale UH, Nagel K, Khan AA, Chan AKC. Thromboembolism in children with lymphoma. Thrombosis Research, 122(4):459‐465, 2008. 86. Whelan HT, Cook JD, Amlie‐Lefond CM, Hovinga CA, Chan AK, Ichord RN, deVeber GA, Thall PF. Practical model‐based dose‐finding in early phase clinical trials: Optimizing tPA dose for treatment of ischemic stroke in children. Stroke, 39(9):2627‐2636, 2008. 87. Domi T, Edgell DS, McCrindle BW, Williams WG, Chan AK, MacGregor DL, Kirton A, deVeber GA. Frequency, predictors, and neurological outcome of vaso‐occlusive strokes associated with cardiac surgery in children. Pediatrics, 122(6):1292‐1298, 2008. 88. Biss TT, Brandao LR, Kahr WH, Chan AK, Williams S. Clinical features and outcome of pulmonary embolism in children. British Journal of Haematology, 142(5):808‐818, 2008. 89. Smith LJ, Mewhort‐Buist TA, Berry LR, Chan AKC*. An antithrombin‐heparin complex increases the anticoagulant activity of fibrin clots. Research Letters in Biochemistry, 2008, Article ID 639829, 4 pages (doi:10.1155/2008/639829). 90. Robertson JD, Brandao L, Williams S, Ing C, Chan AKC. Use of single anti‐Xa calibration curve is adequate for monitoring enoxaparin and tinzaparin levels in children. (Letter) Thrombosis Research, 122(6):867‐869, 2008. 91. Kirton A, Chan AKC, Amlie‐Lefond C. Arterial ischemic stroke: Experience in Chinese children. (Letter). Pediatric Neurology, 39(2):142‐143, 2008. 92. Biss TT, Chan AK, Blanchette VS, Iwenofu LN, McLimont M, Carcao MD, Association of Hemophilia Clinic Directors of Canada (AHCDC), Canadian Association of Nurses in Hemophilia Care (CANHC). The use of prophylaxis in 2,663 children and adults with haemophilia: Results of the 2006 Canadian National Haemophilia prophylaxis survey. Haemophilia, 14(5):923‐930, 2008. 93. Athale U, Siciliano S, Thabane L, Pai N, Cox S, Lathia A, Khan A, Armstrong A, Chan AKC. Epidemiology and clinical risk factors predisposing to thromboembolism in children with cancer. Pediatric Blood & Cancer, 51(6):792‐797, 2008. 94. Monagle P, Chalmers E, Chan A, deVeber G, Kirkham F, Massicotte P, Michelson AD. Antithrombotic therapy in neonates and children: ACCP evidence‐based clinical practice guidelines (8th edition). Chest 133(6 Suppl):887S‐968S, 2008. 95. Young G, Albisetti M, Bonduel M, Brandao L, Chan A, Friedrichs F, Goldenberg N, Grabowski E, Heller C, Journeycake J, Kenet G, Krümpel A, Kurnik K, Lubetsky A, Male C, Manco‐Johnson M, Mathew P, Monagle P, van Ommen H, Simioni P, Svirin P, Tormene D, Nowak‐Göttl U. Impact of inherited thrombophilia on venous thrombo‐embolism in children: a systematic review & meta‐analysis of observational studies. Circulation, 118(13):1373‐1382, 2008.
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96. Amlie‐Lefond C, Chan AKC, Kirton A, deVeber G, Hovinga CA, Ichord R, Stephens D, Zaidat OO. Thrombolysis in acute childhood stroke: Design and challenges of Thrombolysis in Pediatric Stroke clinical trial. Neuroepidemiology, 32(4):279‐286, 2009. 97. Parmar N, Berry LR, Post M, Chan AKC*. Effect of covalent antithrombin‐heparin complex on developmental mechanisms in the lung. American Journal of Physiology: Lung Cellular and Molecular Physiology, 296(3):L394‐L403, 2009. 98. Atkinson HM, Mewhort‐Buist TA, Berry LR, Chan AKC*. Anticoagulant mechanisms of covalent antithrombin‐heparin investigated by thromboelastography ‐ comparison with unfractionated heparin and low molecular weight heparin. Thrombosis and Haemostasis, 102(1):62‐68, 2009. 99. Biss TT, Kahr WH, Brandão LR, Chan AKC, Williams S. The use of elastic compression stockings for post‐thrombotic syndrome in a child. Pediatric Blood and Cancer, 53(3):462‐463, 2009. 100. Amlie‐Lefond C, deVeber G, Chan AK, Benedict S, Bernard T, Carpenter J, Dowling M, Fullerton H, Hovinga C, Kirton A, Lo W, Zamel K, Ichord R, on behalf of members of the International Pediatric Stroke Study. Use of alteplase in childhood arterial ischemic stroke: A multicenter observational cohort study. Lancet Neurology, 8(6):530‐536, 2009. 101. Yee DL, Chan AKC, Williams S, Goldenberg NA, Massicotte MP, Raffini LJ. Varied opinions on thrombolysis for venous thromboembolism in infants and children: Findings from a survey of pediatric hematology‐oncology specialists. Pediatric Blood and Cancer, 53(6):960‐966, 2009. 102. Muwakkit SA, Saab R, Sanjad SA, Bhar SI, Ishak RS, Samad ZA, Chan AK, Abboud MR. Renal venous thrombosis in a newborn with prothrombotic risk factors. Blood Coagulation and Fibrinolysis, 20(6):458‐460, 2009. 103. Berry LR, Thong B, Chan AKC*. Comparison of recombinant and plasma‐derived antithrombin biodistribution in a rabbit model. Thrombosis and Haemostasis, 102(2):302‐308, 2009. 104. Kassam A, Chan AKC, Dzolganovski B, Constantin J, Ramphal R, Grant R, Sung L. No association between protein C levels and bacteremia in children with febrile neutropenia. Journal of Pediatric Hematology/Oncology, 31(9):647‐650, 2009. 105. Biss TT, Brandão LR, Kahr WHA, Chan AKC, Williams S. Clinical probability score and D‐dimer estimation lack utility in the diagnosis of childhood pulmonary embolism. Journal of Thrombosis and Haemostasis, 7(10):1633‐1638, 2009. 106. Mullah‐Ali AM, Chan AK, Lillicrap D, Decker K, Seroski W, Moffat K, Walker I, Pai MK. Undetected factor VIII in a patient with type 3 von Willebrands disease mistakenas severe haemophilia A. Haemophilia, 15(6):1258‐1261, 2009. 107. Chan VHT, Monagle P, Massicotte P, Chan AKC*. Novel paediatric anticoagulants: A review of the current literature. Blood Coagulation and Fibrinolysis, 21(2):144‐151, 2010. 108. Yang JYK, Chan AKC*. Anti‐prothrombin antibodies and other acquired antibodies associated with thrombosis in children. (Editorial). Thrombosis Research, 125:2‐3, 2010.
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109. Moharir MD, Shroff M, Stephens D, Pontigon A, Chan A, MacGregor D, Mikulis D, Adams M, deVeber G. Anticoagulants in pediatric cerebral sinovenous thrombosis: A safety and outcome study. Annals of Neurology, 67(5):590‐599, 2010. 110. Athale U, Moghrabi A, Nayiger T, Delva YL, Thabane L, Chan AKC. von Willebrand factor and thrombin activation in children with newly diagnosed acute lymphoblastic leukemia: An impact of peripheral blasts. Pediatric Blood and Cancer, 54(7):963‐969, 2010. 111. van Walderveen M, Berry LR, Atkinson HM, Chan AKC*. Covalent antithrombin‐heparin effect on thrombin‐thrombomodulin and activated protein C reaction with factor V/Va. Thrombosis and Haemostasis, 103(5):910‐919, 2010. 112. Sask KN, Berry LR, Zhitomirsky I, Chan AK, Brash JL. Surface modification with an antithrombin‐heparin complex for anticoagulation: Studies on a model surface with gold as substrate. Acta Biomaterialia,6(8):2911‐2919, 2010. 113. Kenet G, Lütkhoff LK, Albisetti M, Bernard T, Bonduel M, Brandao L, Chabrier S, Chan A, deVeber G, Fiedler B, Fullerton HJ, Goldenberg NA, Grabowski E, Günther G, Heller C, Holzhauer S, Iorio A, Journeycake J, Junker R, Kirkham FJ, Kurnik K, Lynch JK, Male C, Manco‐ Johnson M, Mesters R, Monagle P, van Ommen CH, Raffini L, Rostásy K, Simioni P, Sträter RD, Young G, Nowak‐Göttl U. Impact of thrombophilia on risk of arterial ischemic stroke or cerebral sinovenous thrombosis in neonates and children: a systematic review and meta‐ analysis of observational studies. Circulation, 121(16):1838‐1847, 2010. 114. van Walderveen MC, Berry LR, Chan AKC*. Effect of covalent antithrombin‐heparin on activated protein C inactivation by protein C inhibitor. Journal of Biochemistry, 148(2):255‐ 260, 2010. 115. Ghanny S, Ross C, Chan A, Chan H. Coagulopathy in a patient with nephrotic syndrome. American Journal of Hematology, 85(9):708‐710, 2010. 116. Chan HH, Brimble KS, Lau KK, Chan AK. Scurvy: an old disease in modern society. The Internet Journal of Internal Medicine, Volume 9, Number 1, 2010. 117. Gruenwald CE, Manlhiot C, Chan AK, Crawford‐Lean L, Foreman C, Holtby HM, Van Arsdell GS, Richards R, Moriarty H, McCrindle BW. Randomized controlled trial of individualized heparin and protamine management in infants undergoing cardiac surgery with cardiopulmonary bypass. Journal of the American College of Cardiology, 56(22):1794‐1802, 2010. 118. Klement P, Berry LR, Liao P, Wood H, Tressel P, Smith LJ, Haque N, Weitz JI, Hirsh J, Paredes N, Chan AKC*. Antithrombin‐heparin covalent complex reduces microemboli during cardiopulmonary bypass in a pig model. Blood 116(25):5716‐5723, 2010. 119. Stevic I, Parmar N, Paredes N, Berry LR, Chan AKC*. Binding of heparin to metals. Cell Biochemistry and Biophysics, 59(3):171‐178, 2011. 120. Nagel K, Laudenbach L, Rivard GE, Jardine L, Chan AK, Pai M. Immune tolerance induction for a patient with factor IX inhibitors: A case report. (Letter). Haemophilia 17(2):315, 2011.
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121. Sask KN, McClung G, Berry LR, Chan AK, Brash JL. Immobilization of antithrombin‐heparin complex on gold: Anticoagulant properties and platelet interactions. Acta Biomaterialia, 7(5):2029‐2034, 2011. 122. Rajpurkar M, Monagle P, Massicotte P, Chan A. Need for a new pediatric post‐thrombotic sequelae outcome measure for non‐extremity thrombosis. (Letter). Thrombosis and Haemostasis, 105(6):1105‐1106, 2011. 123. Muwakkit SA, Majdalani M, Hourani R, Mahfouz RA, Otrock ZK, Bilalian C, Chan AK, Abboud M, Mikati MA. Inherited thrombophilia in childhood stroke: Data from Lebanon. Pediatric Neurology, 45(3):155‐158, 2011. 124. Chan AKC, Decker K, Warner M. Adherence with hemophilia treatments: A survey of hemophilia healthcare professionals in Canada. (Letter). Haemophilia, 17(5):816‐7, 2011. 125. Du YJ, Berry LR, Chan AKC*. Chemical‐physical characterization of polyurethane catheters modified with a novel antithrombin‐heparin covalent complex. Journal of Biomaterial Science ‐ Polymer Edition, 22(17):2277‐2294, 2011. 126. Manlhiot C, Menjak IB, Brandão LR, Gruenwald CE, Schwartz SM, Sivarajan VB, Yoon H, Maratta R, Carew CL, McMullen JA, Clarizia NA, Holtby HM, Williams S, Caldarone CA, Van Arsdell GS, Chan AK, McCrindle BW. Risk, clinical features and outcomes of thrombosis associated with pediatric cardiac surgery. Circulation, 124(14):1511‐1519, 2011. 127. Al‐Aridi C, Abboud MR,Saab R, Eid D, Jeha S, Chan AKC, Muwakkit SA. Thrombosis in children with acute lymphoblastic leukemia treated at a tertiary care center in Lebanon: Revisiting the role of predictive models. Pediatric Hematology and Oncology, 28(8):676‐681, 2011. 128. Nagel K, Walker I, Decker K, Chan AK, Pai MK. Comparing bleed frequency and factor concentrate use between hemophilia A and hemophilia B patients. Haemophilia, 17(6):872‐ 874, 2011. 129. Lau KK, Giglia L, Chan H, Chan AK. Management of children after renal transplantation: Highlights for general prediatricians. [Article in Chinese] Zhongguo Dan Dai Er Ke Za Zhi [Chinese Journal of Contemporary Pediatrics], 14(2):81‐88, 2012. 130. Gruenwald CE, Manlhiot C, Abadilla AA, Kwok J, Maxwell S, Holtby HM, Brandão LR, Chan AK, Crawford‐Lean L, Foreman C, Caldarone CA, Van Arsdell GS, McCrindle BW. Heparin brand is associated with postsurgical outcomes in children undergoing cardiac surgery. Annals of Thoracic Surgery, 93(3):878‐883, 2012. 131. Schechter T, Finkelstein Y, Ali M, Kahr WH, Williams S, Chan AK, deVeber G, Brandão LR. Unfractionated heparin dosing in young infants: Clinical outcomes in a cohort monitored by anti‐Xa levels. Journal of Thrombosis and Haemostasis, 10(3):368‐74, 2012. 132. Monagle P, Chan AK, Goldenberg NA, Ichord RN, Journeycake JM, Nowak‐Göttl U, Vesely SK; American College of Chest Physicians. Antithrombotic therapy in neonate and children: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest
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Physicians Evidence‐based Clinical Practice Guidelines. Chest, 141(2 Suppl):e737S‐e801S, 2012. 133. Atkinson HM, Parmar N, Berry LR, Chan AKC*. Determination of alpha‐2‐macroglobulin complexes by a new immuno‐activity assay. Thrombosis Research, 129(5):635‐640, 2012. 134. Manlhiot C, McCrindle BW, Menjak IB, Yoon H, Holtby HM, Brandão LR, Chan AK, Schwartz SM, Sivarajan BV, Crawford‐Lean L, Foreman C, Caldarone CA, Van Arsdell GS, Gruenwald CE. Longer blood storage is associated with suboptimal outcomes in high‐risk pediatric cardiac surgery. Annals of Thoracic Surgery, 93(5):1563‐1569, 2012. 135. Athale U, Siciliano S, Cheng E, Thabane L, Chan AKC. Central venous line dysfunction is an independent predictor of poor survival in children with cancer. Journal of Pediatric Hematology/Oncology, 34(3):188‐193, 2012. 136. Newall F, Chan AK, Ignjatovic V, Monagle P; on behalf of the Perinatal and Paediatric Haemostasis Subcommittee of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis. Recommendations for developing uniform laboratory monitoring of heparinoid anticoagulants in children. Journal of Thrombosis and Haemostasis, 10(1):145‐147, 2012. 137. Schechter T, Kirton A, Laughlin S, Pontigon AM, Finkelstein Y, MacGregor D, Chan A, deVeber G, Brandão LR. Safety of anticoagulants in children with arterial ischemic stroke. Blood, 119(4):949‐956, 2012. 138. Sask KN, Berry LR, Chan AKC, Brash JL. Modification of polyurethane surface with an antithrombin‐heparin complex for blood contact: Influence of molecular weight of polyethylene oxide used as linker/spacer. Langmuir, 28(4):2099‐2106, 2012. 139. Goldenberg NA, Brandão LR, Journeycake J, Kahn SR, Monagle P, Revel‐Vilk S, Sharathkumar A, Chan AKC; on behalf of the Perinatal and Paediatric Haemostasis Subcommittee of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis. Definition of post‐thrombotic syndrome (PTS) and standardization outcome measurement following lower extremity deep vein thrombosis in paediatric clinical investigations. Journal of Thrombosis and Haemostasis, 10(3):477‐480, 2012. 140. Kaatz S, Kouides PA, Garcia DA, Spyropolous AC, Crowther M, Douketis JD, Chan AKC, James A, Moll S, Ortel TL, Van Cott EM, Ansell J. Guidance on the emergent reversal of oral thrombin and factor Xa inhibitors. American Journal of Hematology, 87(Suppl 1):S141‐S145, 2012. 141. Tuckuviene R, Christensen AL, Chan AKC, Athale U. Body mass index and thromboembolism in children with hematological malignancies. Pediatric Blood and Cancer, 59(2):320‐322, 2012. 142. Lau KK, Giglia L, Chan H, Chan AK. Management of children after renal transplantation: Highlights for general prediatricians. Translational Pediatrics, 1(1):35‐46, 2012. 143. Stevic I, Berry LR, Chan AKC. Mechanism of inhibition of the prothrombinase complex by a covalent antithrombin‐heparin complex. Journal of Biochemistry, 152(2):139‐148, 2012
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144. Almonte T, Deckeer K, Seroski W, Walker I, Wevert K, Bos C, Strike K, Waterhouse L, Goldsmith R, Chan AKC. The importance of hemophilia treatment centre administrators in patient care. (Letter) Haemophilia (accepted, 2012). 145. Sask KN, Berry LR, Chan AKC, Brash JL. Polyurethane modified with an antithrombin‐heparin complex (ATH) via polyethylene oxide (PEO) linker/spacer: Influence of PEO molecular weight and PEO‐ATH bond on catalytic and direct anticoagulant functions. Journal of Biomedical Materials Research: Part A, (accepted, 2012). 146. Manlhiot C, Brandao LR, Kwok J, Kegel S, Menjak IB, Carew CL, Chan AK, Schwartz SM, Sivarajan VB, Caldarone CA, Van Arsdell GS, McCrindle BW. Thrombotic complications and thromboprophylaxis across all three stages of single ventricle heart palliation. Journal of Pediatrics, (accepted, 2012). 147. Revel‐Vilk S, Brandão LR, Journeycake J, Goldenberg A, Monagle P, Sharathkumar A, Chan AKC; on behalf of the Perinatal and Paediatric Haemostasis Subcommittee of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis. Standardization of post‐thrombotic syndrome (PTS) definition and outcome assessment following upper venous system thrombosis in pediatric clinical investigations. Journal of Thrombosis and Haemostasis, (accepted, 2012). 148. Nagel K, Pai MK, Paes BA, Chan AK. Diagnosis and treatment of intracranial hemorrhage in children with hemophilia. Blood Coagulation and Fibrinolysis, (accepted, 2012). 149. Teitel J, Belliveau D, Blanchette V, Chan A, Klaassen R, Price V, Ritchie B, Wu J. A Canadian survey of self‐infusion practices in persons with hemophilia A. Haemophilia, (accepted, 2012). REVIEW ARTICLES (Peer‐Reviewed) 1. Chan AKC, deVeber G. Prothrombotic disorders and ischemic stroke in children. Seminars in Pediatric Neurology 7(4):301‐308, 2000. 2. Andrew ME, Monagle P, deVeber G, Chan AKC. Thromboembolic disease and antithrombotic therapy in newborns. Hematology (American Society of Hematology Education Program) 358‐ 374, 2001. 3. Kuhne S, Chan AKC. Neonatal thrombosis. ADVANCE for Medical Laboratory Professionals 14(16), 2002. 4. Chan AK, deVeber G, Monagle P, Brooker LA, Massicotte PM. Venous thrombosis in children. Journal of Thrombosis and Haemostasis 1(7):1443‐1455, 2003. 5. Revel‐Vilk S, Chan AKC*. Anticoagulation therapy in children. Seminars in Thrombosis and Hemostasis 29(4):425‐432, 2003. 6. Athale UH, Chan AKC. Thrombosis in children with acute lymphoblastic leukemia. Part I. Dr. Anthony Chan Page 13
Epidemiology of thrombosis in children with acute lymphoblastic leukemia. Thrombosis Research 111(3):125‐131, 2003.
7.
Athale UH, Chan AKC. Thrombosis in children with acute lymphoblastic leukemia. Part II. Pathogenesis of thrombosis in children with acute lymphoblastic leukemia: Effects of the disease and therapy. Thrombosis Research. 111(4‐5):199‐212, 2003.
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Athale UH, Chan AKC. Thrombosis in children with acute lymphoblastic leukemia. Part III. Pathogenesis of thrombosis in children with acute lymphoblastic leukemia: Effects of host environment. Thrombosis Research. 111(6):321‐327, 2003.
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Berry L, Chan AKC*. Development of antithrombin‐heparin covalent complexes. Current Topics in Biochemical Research 5:121‐131, 2003.
10. Sutor AH, Chan AKC, Massicotte P. Low‐molecular‐weight heparin in pediatric patients. Seminars in Thrombosis Hemostasis 30(Suppl 1):31‐39, 2004.
11. Lequier L, Chan AKC. Anticoagulation during extracorporeal life support. Progress in Pediatric Cardiology 21(1): 81‐85, 2005.
12. Chan AK, deVeber G, Gruenwald C, Yager J, Massicotte MP. Cardiopulmonary bypass and arterial ischemic stroke in infants and children. Progress in Pediatric Cardiology 21(1):117‐121, 2005.
13. Bajzar L, Chan AK, Massicotte MP, Mitchell LG. Thrombosis in children with malignancy. Current Opinion in Pediatrics 18(1):1‐9, 2006.
14. Brandao LR, Williams S, Kahr WHA, Clodagh R, Temple M, Chan AKC. Exercise‐induced deep vein thrombosis of the upper extremity. 1. Literature review. Acta Haematologica 115(3‐ 4):214‐220, 2006.
15. Parmar N, Albisetti M, Berry L, Chan AKC*. The fibrinolytic system in newborns and children. Clinical Laboratory 52(3‐4):115‐24, 2006.
16. Lau K, Liu G, Chan AKC. Management of asymptomatic proteinuria in children: Role of general practitioner. The Hong Kong Practitioner 28:383‐387, 2006.
17. Patel S, Berry LR, Chan AKC*. Covalent antithrombin‐heparin complexes. Thrombosis Research, 120(2):151‐160, 2007.
18. Athale UH, Chan AKC. Thromboembolic complications in pediatric hematologic malignancies. Seminars in Thrombosis and Hemostasis 33(4):416‐426, 2007.
19. Athale UH, Chan AKC. Hemorrhagic complications in pediatric hematologic malignancies. Seminars in Thrombosis and Hemostasis 33(4):408‐415, 2007.
20. Price VE, Hawes SA, Chan AKC. A practical approach to hemophilia care in children. Paediatrics & Child Health 12(5):381‐383, 2007.
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21. Lau KK, Stoffman JM, Williams S, McCusker P, Brandao L, Patel S#, Chan AKC*; for the Canadian Pediatric Thrombosis and Hemostasis Network. Neonatal renal vein thrombosis: Review of the English‐language literature between 1992 to 2006. Pediatrics, 120(5):e1278‐e1284, 2007.
22. Kakzanov V, Monagle P, Chan AKC*. Thromboembolism in infants and children with gastrointestinal failure receiving long‐term Total Parenteral Nutrition. Journal of Parenteral and Enteral Nutrition 32(1):88‐93, 2008.
23. Price VE, Chan AKC. Arterial thrombosis in children. Expert Review of Cardiovascular Therapy 6(3):419‐428, 2008.
24. Price VE, Chan AKC. Venous thrombosis in children. Expert Review of Cardiovascular Therapy 6(3):411‐418, 2008.
25. Berry LR, Chan AKC*. Review on patents for potent anticoagulant antithrombin‐heparin covalent complexes that control thrombosis in vivo. (Invited Review) Recent Patents on Biomedical Engineering, 1(2):82‐91, 2008.
26. Malowany JI, Monagle P, Knoppert DC, Lee DSC, Wu J, McCusker P, Massicotte MP, Williams S, Chan AKC, for the Canadian Paediatric Thrombosis and Hemostasis Network. Enoxaparin for neonatal thrombosis: A call for higher dose for neonates. Thrombosis Research, 122(6):826‐ 830, 2008.
27. Yang J, Paredes N, Chan AKC*. Antithrombotic therapy in children with venous thromboembolism. Hämostaseologie, 29(1):80‐87, 2009.
28. van Walderveen MC, Berry LR, Chan AKC*. Intravascular targeting of a new anticoagulant heparin compound. Cardiovascular & Hematological Disorders ‐ Drug Targets, 9(2):149‐158, 2009.
29. Gruenwald CE, Manlhiot C, Crawford‐Lean L, Foreman C, Brandão LR, McCrindle BW, Holtby H, Richards R, Moriarty H, Van Arsdell G, Chan AK. Management and monitoring of anticoagulation for children undergoing cardiopulmonary bypass in cardiac surgery. The Journal of Extracorporeal Technology, 42(1):9‐19, 2010.
30. Nagel K, Tuckuviene R, Paes B, Chan AK*. Neonatal aortic thrombosis: A comprehensive review. Klinische Pädiatrie, 222(1):134‐139, 2010.
31. Yang JY, Williams S, Brandão LR, Chan AKC*. Neonatal and childhood right atrial thrombosis: Recognition and risk‐stratified treatment approach. Blood Coagulation and Fibrinolysis, 21(4):301‐307, 2010.
32. Yang JYK, Chan AKC, Callen DJA, Paes B. Neonatal cerebral sinovenous thrombosis: Sifting the evidence for a diagnostic plan and treatment strategy. Pediatrics, 126(3):e693‐e700, 2010.
33. Kenet G, Chan AKC, Soucie MJ, Kulkarni R. Bleeding disorders in neonates. Haemophilia,
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16(Suppl 5):168‐174, 2010.
34. Yang YK, Chan AKC*. Neonatal systemic venous thrombosis. Thrombosis Research, 126(6):471‐476, 2010.
35. Paredes N, Mondal T, Brandão LR, Chan AKC*. Management of myocardial infarction in children with Kawasaki disease. Blood Coagulation and Fibrinolysis, 21(7):620‐631, 2010.
36. Iorio A, Marchesini E, Marcucci M, Stobart K, Chan AKC. Clotting factor concentrates given to prevent bleeding and bleeding‐related complications in people with hemophilia A or B. (Intervention Review) Cochrane Database of Systematic Reviews, (9):CD003429, 2011.
37. Stevic I, Chan HH, Chan AKC*. Carotid artery dissections: Thrombosis of the false lumen. Thrombosis Research, 128(4):317‐324, 2011.
38. Price VE, Ledingham DL, Krümpel A, Chan AK. Diagnosis and management of neonatal purpura fulminans. Seminars in Fetal and Neonatal Medicine, 16(6):318‐322, 2011.
39. Williams S, Chan AKC. Neonatal portal vein thrombosis: Diagnosis and management. Seminars in Fetal and Neonatal Medicine, 16(6):329‐339, 2011.
40. Macartney CA, Chan AKC*. Thrombosis in children. Seminars in Thrombosis and Hemostasis, 37(7):763‐771, 2011. PUBLICATIONS (Non Peer‐Reviewed): 1. Jamieson MA, Douketis J, Chan AK, Massicotte P. Opinions in pediatric and adolescent gynecology. Does oral contraceptive therapy do more harm than good in adolescents who are receiving chemotherapy? Journal of Pediatric and Adolescent Gynecology 16(6):377‐9, 2003. 2. Monagle P, Chan AK. Pediatric edition thrombosis research. (Editorial) Thrombosis Research 118(1):1‐2, 2006. 3. Chan HH, Chan AK, Lau KK. A surfacing problem. Ibnosina Journal of Medicine and Biomedical Sciences 4(3):103‐105, 2012. CONTRIBUTIONS TO A COLLECTIVE WORK Published Peer‐Reviewed Articles 1. deVeber G, Andrew M, Adams C, Bjornson B, Booth F, Buckley DJ, Camfield CS, David M, Humphreys P, Langevin P, MacDonald EA, Gillett J; for the Canadian Pediatric Ischemic Stroke Study Group. Cerebral sinovenous thrombosis in children. New England Journal of Medicine 345(6):417‐423, 2001. 2. Massicotte P, Julian JA, Gent M, Shields K, Marzinotto V, Szechtman B, Andrew M: REVIVE Dr. Anthony Chan Page 16
Study Group. An open‐label randomized controlled trial of low molecular weight heparin compared to heparin and coumadin for the treatment of venous thromboembolic events in children: the REVIVE trial. Thrombosis Research 109(2‐3):85‐92, 2003. 3.
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O'Brien LA, James PD, Othman M, Berber E, Cameron C, Notley CRP, Hegadorn CA, Sutherland JJ, Hough C, Rivard GE, O'Shaunessey D, Lillicrap D: Association of Hemophilia Clinic Directors of Canada. Founder von Willebrand factor haplotype associated with type 1 von Willebrand disease. Blood 102(2):549‐557, 2003. Arnold DM, Julian JA, Walker IR: for the Association of Hemophilia Clinic Directors of Canada. Mortality rates and causes of death among all HIV‐positive individuals with hemophilia in Canada over 21 years of follow‐up. Blood 108(2):460‐464, 2006. James PD, Paterson AD, Notley C, Cameron C, Hegadorn C, Tinlin S, Brown C, O'Brien L, Leggo J, Lillicrap D; Association of Hemophilia Clinic Directors of Canada. Genetic linkage and association analysis in type 1 von Willebrand disease: Results from the Canadian Type 1 VWD study. Journal of Thrombosis and Haemostasis 4(4):783‐92, 2006. Feldman BM, Pai M, Rivard GE, Israels S, Poon MC, Demers C, Robinson S, Luke KH, Wu JKM, gill K, Lillicrap D, Babyn P, McLimont M, Blanchette BS: on behalf of the Association of Hemophilia Clinic Directors of Canada Prophylaxis Study Group. Tailored prophylaxis in severe hemophilia A: interim results for the first 5 years of the Canadian Hemophilia Primary Prophylaxis Study. Journal of Thrombosis and Haemostasis 4(6):1228‐1236, 2006. James PD, Notley C, Hegadorn C, Poon MC, Walker I, Rapson D; Association of Hemophilia Clinic Directors of Canada. Challenges in defining type 2M von Willebrand disease: results from a Canadian cohort study. Journal of Thrombosis and Haemostasis, 5(9):1914‐1922, 2007. Golomb MR, Fullerton HJ, Nowak‐Göttl U, deVeber G, and for the International Pediatric Stroke Study Group. Male predominance in childhood ischemic stroke. Findings from the International Pediatric Stroke Study. Stroke, 40(1):52‐57, 2009. Amlie‐Lefond C, Bernard TJ, Sébire G, Friedman NR, Heyer GL, Lerner NB, deVeber G, Fullerton HJ, on behalf of the International Pediatric Stroke Study Group. Predictors of cerebral arteriopathy in children with arterial ischemic stroke: Results of the International Pediatric Stroke Study. Circulation, 119(10):1417‐1423, 2009.
10. Goldenberg NA, Bernard TJ, Fullerton HJ, Gordon A, deVeber G, for the International Pediatric Stroke Study Group. Antithrombotic treatments, outcomes, and prognostic factors in acute childhood‐onset arterial ischaemic stroke: A multicentre, observational, cohort study. Lancet Neurology, 8(12):1120‐1127, 2009. 11. Jordan LC, Rafay MF, Smith SE, Askalan R, Zamel K, deVeber G, Ashwal S, for the International Pediatric Stroke Study Group. Antithrombotic treatment in neonatal cerebral sinovenous thrombosis: Results of the International Pediatric Stroke Study. Journal of Pediatrics, 156(5):704‐710, 2010. 12. Kirton A, Armstrong‐Wells J, Chang T, deVeber G, Rivkin MJ, Hernandez M, Carpenter J, Yager JY, Lynch JK, Ferriero DM, and for the International Pediatric Stroke Study Investigators.
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Symptomatic neonatal arterial ischemic stroke: The International Pediatric Stroke Study. Pediatrics, 128(6):e1402‐e1410, 2011. 13. Mackay MT, Wiznitzer M, Benedict SL, Lee KJ, deVeber GA, Ganesan V, on behalf of the International Pediatric Stroke Study Group. Arterial ischemic stroke risk factors: The International Pediatric Stroke Study. Annals of Neurology, 69(1):130‐140, 2011. Abstracts (Oral Presentation) 1.
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deVeber G for the Canadian Pediatric Ischemic Stroke Study Group. Canadian Pediatric Ischemic Stroke Registry: Analysis of children with arterial ischemic stroke. Child Neurology Society 29th Annual Meeting, 2000, St Louis, MO. deVeber G for the Canadian Pediatric Ischemic Stroke Study Group. Canadian Pediatric Ischemic Stroke Registry: Analysis of children with sinovenous thrombosis. Canadian Congress of Neurological Sciences Meeting, 2000, Ottawa, ON. Massicotte P, Julian JA , Gent M, Shields K, Marzinotto V, Szechtman B, Andrew M: on behalf of the REVIVE Study Group (Canada). An open‐label randomized controlled trial of low molecular weight heparin compared to heparin and coumadin for the treatment of venous thromboembolic events in children: The REVIVE trial. XVIII Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2001, Paris, France. deVeber G, Kirton A, The Canadian Pediatric Ischemic Stroke Study Group. Arterial ischemic stroke in infants and children: A prospective epidemiological study. 35th Annual Meeting of the Child Neurology Society, 2006, Pittsburgh, PA. deVeber G, Kirton A, The Canadian Pediatric Ischemic Stroke Study Group. Neonatal stroke in the Canadian Pediatric Ischemic Stroke Registry. 49th Pediatric Academic Societies’ Annual Meeting, 2007, Toronto, ON.
6. Amlie‐Lefond C, Bernard T, Sébire G, Friedman N, Heyer G, Lerner N, deVeber G, Fullerton H, on behalf of the International Pediatric Stroke Study Group. Predictors of cerebral arteriopathy in children with arterial ischemic stroke: Results of the International Pediatric Stroke Study. 2009 International Stroke Conference, American Heart Association, 2009, San Diego, CA (Stroke 2009; 40:e105‐e276; Abstract #71). 7. Jordan L, Smith S, Rafay M, Zamel K, Askalon R, Ashwal S and Members of the International Pediatric Stroke Study Group. Predictors of antithrombotic treatment in neonatal cerebral sinovenous thrombosis: Results of the International Pediatric Stroke Study. 2009 International Stroke Conference, American Heart Association, 2009, San Diego, CA (Stroke 2009; 40:e105‐ e276; Abstract #75). Abstracts (Posters)
1.
MacGregor D for the Canadian Paediatric Ischemic Stroke Study Group. Craniocervical arterial dissection in a paediatric population. Canadian Congress of the Neurological Sciences Dr. Anthony Chan Page 18
Meeting, 2000, Ottawa, ON.
2.
deVeber G for the Canadian Paediatric Ischemic Stroke Study Group. Canadian Paediatric Ischemic Stroke Registry. Canadian Paediatric Society Annual Meeting, 2000, Ottawa, ON.
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International Paediatric Stroke Study Group. Establishing a multinational research network in paediatric stroke: The International Paediatric Stroke Study Group. 35th Annual Meeting of the Child Neurology Society, 2006, Pittsburgh, PA.
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International Paediatric Stroke Study Group. The importance of arteriopathy in arterial ischemic stroke in children: Results from the International Paediatric Stroke Study. 35th Annual Meeting of the Child Neurology Society, 2006, Pittsburgh, PA.
5.
Billinghurst LL, deVeber G, The Canadian Pediatric Ischemic Stroke Study Group. Cerebral venous sinus thrombosis and common childhood illness. 36th Annual Meeting of the Child Neurology Society, 2008, Santa Clara, CA.
WEB PUBLICATION 1. Chan A, David M, Massicotte P. Warfarin therapy in children. (http://www.tigc.org/clinical‐ guides/Warfarin‐in‐Children.aspx), 2009. 2. Massicotte P, David M, Chan A. Thrombolytic therapy in children. (http://www.tigc.org/clinical‐guides/Thrombolytic‐Therapy‐in‐Children.aspx), 2009. 3. Chan A, David M, Massicotte P. Heparin and LMWH in children. (http://www.tigc.org/clinical‐ guides/Heparin‐and‐LMWH‐in‐Children.aspx), 2009. 4. Chan AKC, Chan HHW, Berry LR. Chapter 24 ‐ Vitamin K. In: Mechanisms in Hematology. Israels S (Ed), Concord, ON, Canada, 2010. (http://www.mechanismsinhematology.ca/contents.aspx) 5. Chan AKC, Chan HHW, Berry LR. Chapter 25 ‐ Fibrinogen, Factor XIII and Fibrinolysis. In: Mechanisms in Hematology. Israels S (Ed), Concord, ON, Canada, 2010. (http://www.mechanismsinhematology.ca/contents.aspx) BOOKS 1. Monagle P, Chan AKC, deVeber G, Massicotte M. Andrew's Pediatric Thromboembolism and Stroke. (Third Edition ) BC Decker, Hamilton 2006. BOOK CHAPTERS 1. Bagnall‐Reeb H, Chan AKC, Darouiche R, Jones G, Ryder M. Managing patients with venous access device‐related venous thrombosis. IN: Apha Guide to Drug Treatment Protocols: A Dr. Anthony Chan Page 19
Resource for Creating and Using Disease‐Specific Pathways. Manolakis PG, Albrant DH (Eds) American Pharmaceutical Association, 1998. 2. Monagle P, Chan A. Management of VTE in Paediatric Patients. In: Critical Decisions in Thrombosis and Hemostasis. Ginsberg J, Kearon C, Hirsh J (Eds), B.C. Decker Inc., Hamilton, 1998. 3. Berry L, Andrew M, Chan AKC. Antithrombin‐Heparin Complexes (Chapter 25). In: Polymeric Biomaterials. Part II: Medical and Pharmaceutical Applications of Polymers. (Second Edition). Dumitriu S (Ed), Marcel Dekker Inc., New York, NY, 2002. 4. Chan A. Pathogenesis, Clinical Manifestations, and Diagnosis of Thrombosis in the Newborn. In: UpToDate. Rose BD (Ed), UpToDate, Wellesley, MA, 2002 (Annual Review). 5. Chan A. Management of Thrombosis in the Newborn. In: UpToDate. Rose BD (Ed), UpToDate, Wellesley, MA, 2002 (Annual Review). 6. Albisetti M, Chan AKC. Pathogenesis and Clinical Manifestations of Venous Thromboembolism in Infants and Children. In: UpToDate. Rose BD (Ed), UpToDate, Wellesley, MA, 2004 (Annual Review). 7. Albisetti M, Chan AKC. Diagnosis and Treatment of Venous Thromboembolism in Infants and Children. In: UpToDate. Rose BD (Ed), UpToDate, Wellesley, MA, 2004 (Annual Review). 8. Blanchette VS, Dror Y, Chan AKC. Hematology. In: Avery’s Neonatology: Pathophysiology and Management of the Newborn. (6th Edition). MacDonald M, Seshia MMK, Mullett MD (Eds), Lippincott Williams & Wilkins, Philadelphia PA, 2005. 9. Massicotte P, Monagle P, Chan AKC. Systemic Thrombosis in Children. In: Thrombosis in Clinical Practice. Blann A, Lip GYH, Turpie AGG (Eds), Taylor & Francis, New York, NY, 2005. 10. Berry LR, Chan AKC. Improving Blood Compatibility of Biomaterials Using a Novel Antithrombin‐Heparin Covalent Complex. In: Biomaterials Fabrication and Processing Handbook. Chu PK, Lui X (Eds), CRC Press/Taylor and Francis Group, New York, 2008. 11. Chan AKC, Monagle P. Pediatric Thrombosis. In: Evidence‐based Hematology. Crowther M, Ginsberg J, Schünemann H, Meyer RM, Lottenberg R (Eds), Wiley‐Blackwell BMJ Books, Malden, MA, 2008. 12. Monagle P, Chan AKC. Anticoagulation in Children. In: New Therapeutic Agents in Thrombosis and Thrombolysis. (Third Edition). Freedman J, Loscalzo J (Eds), Informa Healthcare, New York, NY, 2009. 13. Chan AKC, Odame I. Coagulation Disorders. In: Manual of Pediatric Intensive Care. Kirpalani H, Huang L, Duffett M, Michenko M (Eds), PHMP/BC Decker, Hamilton, 2009. 14. Athale UH, Yang JYK, Chan AKC. Thromboembolism in Children with Cancer. In: UpToDate. Rose BD, Basow DS (Eds), UpToDate, Waltham, MA, 2010 (Annual Review).
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15. Chan AKC, Paredes N, Monagle P, deVeber G. Chapter 4 ‐ Prothrombotic Disorders and Ischemic Stroke in Children. In: Ischemic Stroke in Childhood. González G, Arroyo H, Crosa R, Russi ME (Eds), pp. 113‐134, Panamericana, Argentina, 2011. (Translated into Spanish: Trastornos protrombóticos y accidente cerbrovascular isquémico. In: Accidente certrobascular en la infancia y adolescencia.) 16. Journeycake J, Yang J, Chan AKC. Normal and Abnormal Hemostasis. In: Rudolph’s Pediatrics. (22nd Edition). Rudolph CD, Rudolph AM, Lister GE, First LR, Gershon AA (Eds), McGraw‐Hill, New York, 2011. 17. Journeycake J, Chan AKC. Diagnosis and Management of Thrombosis. In: Rudolph’s Pediatrics. (22nd Edition). Rudolph CD, Rudolph AM, Lister GE, First LR, Gershon AA (Eds), McGraw‐Hill, New York, 2011. 18. Bauman ME, Chan V, Chan AKC, Massicotte MP. Unique Challenges with Hemostatic Testing in Children. Chapter 8. In: Quality in Laboratory Hemostasis and Thrombosis. Kitchen S, Olson JD, Preston FE (Eds), Wiley‐Blackwell, (accepted, 2012). 19. Macartney CA, Paredes N, Chan AKC. Disorders of Coagulation in the Neonate. Chapter 152. In: Hematology, Basic Principles and Practice, Sixth Edition. Hoffman R, Weitz JI, Heslop H (Eds). Elsevier (accepted, 2012). 20. Chan HHW, Chan AKC, Alexopoulou I, Lau KK. Thrombotic Thrombocytopenic Purpura. Current Pediatric Reviews, (accepted, 2011). 21. Chan HHW, Chan AKC, Alexopoulou I, Lau KK. Current Guidelines and Strategies in Management of Renal Vein Thrombosis. Current Pediatric Reviews, (accepted, 2011).
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