Quantification of myocardial blood flow using dynamic 320-row multi-detector CT as compared with 15O-H2O PET Yasuka Kikuchi, Noriko OyamaManabe, Masanao Naya, Osamu Manabe, Yuuki Tomiyama, Tsukasa Sasaki, Chietsugu Katoh, Kohsuke Kudo, et al. European Radiology ISSN 0938-7994 Eur Radiol DOI 10.1007/s00330-014-3164-3
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Author's personal copy Eur Radiol DOI 10.1007/s00330-014-3164-3
CARDIAC
Quantification of myocardial blood flow using dynamic 320-row multi-detector CTas compared with 15O-H2O PET Yasuka Kikuchi & Noriko Oyama-Manabe & Masanao Naya & Osamu Manabe & Yuuki Tomiyama & Tsukasa Sasaki & Chietsugu Katoh & Kohsuke Kudo & Nagara Tamaki & Hiroki Shirato
Received: 31 December 2013 / Revised: 10 March 2014 / Accepted: 24 March 2014 # European Society of Radiology 2014
Abstract Objectives This study introduces a method to calculate myocardium blood flow (MBF) and coronary flow reserve (CFR) using the relatively low-dose dynamic 320-row multi-detector computed tomography (MDCT), validates the method against 15 O-H2O positron-emission tomography (PET) and assesses the CFRs of coronary artery disease (CAD) patients. Methods Thirty-two subjects underwent both dynamic CT perfusion (CTP) and PET perfusion imaging at rest and during pharmacological stress. In 12 normal subjects (pilot group), the calculation method for MBF and CFR was established. In the other 13 normal subjects (validation group), MBF and CFR obtained by dynamic CTP and PET were compared. Finally, the CFRs obtained by dynamic CTP and PET were
Y. Kikuchi : N. Oyama-Manabe (*) : K. Kudo Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Kita15, Nishi 7, kita-ku, Sapporo 060-8638, Japan e-mail:
[email protected] M. Naya Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan O. Manabe : Y. Tomiyama : N. Tamaki Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan T. Sasaki Department of Radiology, Hokkaido University Hospital, Sapporo, Japan C. Katoh Hokkaido University Faculty of Health Sciences, Sapporo, Japan H. Shirato Department of Radiation Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
compared between the validation group and CAD patients (n=7). Results Correlation between MBF of MDCT and PET was strong (r=0.95, P
