Nov 9, 2016 - A giant cell tumor of the bone (GCTB) is a primary intramedullary bone tumor composed of ..... Giant cell tumor of the tendon sheath of the toe.
www.nature.com/scientificreports
OPEN
received: 18 March 2016 accepted: 13 October 2016 Published: 09 November 2016
Recurrence Rates and Risk Factors for Primary Giant Cell Tumors around the Knee: A Multicentre Retrospective Study in China Pan Hu1, Liming Zhao2,3, Huilin Zhang2,3, Xiuchun Yu4, Zhen Wang5, Zhaoming Ye6, Sujia Wu7, Shibing Guo8, Guochuan Zhang9, Jinghua Wang10, Xianjia Ning10, Yongcheng Hu2 & Yingze Zhang1 Giant cell tumors of the bone (GCTBs) are commonly diagnosed in Asian populations, usually around the knee. Herein, we aimed to determine the clinical characteristics, local recurrence rates, and relevant risk factors of primary GCTB around the knee. Univariate and multivariate survival analyses were used to identify the risk factors for local recurrence. Four hundred ten patients with primary GCTB around the knee, treated between March 2000 and June 2014, were recruited from 7 institutions in China. The overall local recurrence rate was 23.4%, but was higher in patients aged 20–39 years (28.5%; P = 0.039). The local recurrence rate was the highest in patients treated with intralesional curettage (53.4%), and the lowest in those treated with resection (4.9%). We found a higher risk of tumor recurrence in the proximal fibula compared to the distal femur (hazard ratio: 28.52, 95% confidence interval: 5.88–138.39; P
