L McCauley, M Robinson, L Samawi, P Finan, L Buenaver, C Campbell, and M ... M Petrov, T Glover, B Goodin, L Bradley, and R Fillingim; University of Alabama.
Abstracts
B. Disease Entities (Human) B01 Arthritis and Other Joint Pains (204) Correlations between pain, sleep and psychological variables in osteoarthritis patients L McCauley, M Robinson, L Samawi, P Finan, L Buenaver, C Campbell, and M Smith; Johns Hopkins University, School of Medicine, Baltimore, MD Osteoarthritis is a chronic degenerative disorder associated with, but not produced by, aging; the primary symptom being pain. As the population ages, it is important to understand the factors associated with the disease. Sleep and psychological factors, such as catastrophizing, are becoming increasingly more recognized as factors that influence and affect the experience of pain. For example, a complex, bidirectional relationship exists between sleep and pain, such that poor sleep quality and lower sleep duration produces increased pain, and greater pain negatively impacts sleep. In addition, catastrophizing, a generally negative mental set, is one psychological factor known to have profound influence over pain reports. As part of a knee osteoarthritis (KOA) pain and insomnia intervention study, participants were placed into four groups based on diagnostic eligibility criteria: healthy controls (no KOA or insomnia); KOA, no insomnia; no KOA, insomnia; and KOA, insomnia. A total of 205 participants underwent baseline testing; including heat and pressure threshold sensory testing on multiple body sites and completed various clinical pain and sleep measures. After controlling for age, an Analysis of Variance (ANOVA) revealed a significant pressure pain threshold (PPT) difference at the quadriceps muscle between groups, with the KOA insomnia group having the lowest threshold (p=.007). Other measures of pressure and heat pain threshold were non-significant. However, correlations between laboratory pain measures, clinical pain and sleep measures were significant across all groups (p30ng/mL greater clinical pain predicted poorer sleep quality. Vitamin D group differences in sleep quality were significantly mediated by group differences in clinical pain (Coefficient = 0.67, SE = 0.40, 95% CI: 0.05-1.57) after controlling for age, race, body mass index, and symptoms of depression. Poor sleep quality, among middle-aged to older adults with osteoarthritis of the knee and vitamin D inadequacy, is partially explained by clinical pain.
M Auster and G Gong; Johns Hopkins Bayview Medical Center, Baltimore, MD
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