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Relationship between oxidative stress and diabetic osteopenia in premenopausal rats Valéria Morgiana Gualberto Duarte1, Alanna de Sousa Rodrigues2, Luciana Augusto de Rezende3, Ana Maria de Oliveira Ramos4, Rodrigo Medeiros de Souza5, Francisco Paulo Freire Neto6, Aldo da Cunha Medeiros6, José Brandão Neto6, Maria das Graças Almeida7, Adriana Augusto de Rezende7,* Department of Pharmacy, School of Pharmacy, State University of Paraíba, Paraíba, Brazil, 2Clinical Analysis Laboratory, Hospital São José, Ceará, Brazil, 3Department of Chemistry, School of Chemistry, University of Ribeirão Preto, São Paulo, Brazil, 4Department of Clinical Pathology, School of Medicine, Federal University of Rio Grande do Norte, Rio Grande do Norte, Brazil, 5Nursing School, Federal University of Acre, Acre, Brazil, 6Department of Medicine, School of Medicine, Federal University of Rio Grande do Norte, Rio Grande do Norte, Brazil, 7Department of Clinical Analysis and Toxicology, Federal University of Rio Grande do Norte, Rio Grande do Norte, Brazil
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The relationship between lipid peroxidation, antioxidant defense and diabetic osteopenia remains unclear. This study evaluated the relationship among lipid peroxidation index, antioxidant defense parameters and bone metabolism in a premenopausal diabetic model using measures including thiobarbituric acidreactive substances concentration (TBARS) and reduced glutathione (GSH) content in brain homogenates, histomorphometric analysis, biomechanical testing and bone mineral density (BMD). Female Wistar rats with regular estrous cycle were divided into two groups: Group 1: control rats (n = 15) and Group 2: diabetic rats (n = 15). Diabetes was induced by alloxan and confirmed by glycemia ≥250 mg/dL. The lipid peroxidation index, measured by TBARS concentration, showed a significant increase (p
