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Original Article Ann Rehabil Med 2016;40(1):56-65 pISSN: 2234-0645 • eISSN: 2234-0653 http://dx.doi.org/10.5535/arm.2016.40.1.56
Annals of Rehabilitation Medicine
Relationship of Vascular Factors on Electrophysiologic Severity of Diabetic Neuropathy Jeong-Won Hwang, MD1, Sung-Bom Pyun, MD, PhD1,2, Hee Kyu Kwon, MD, PhD1 1
Department of Physical Medicine and Rehabilitation, Korea University College of Medicine, Seoul; 2 Brain Convergence Research Center, Korea University Anam Hospital, Seoul, Korea
Objective To investigate the impact of vascular factors on the electrophysiologic severity of diabetic neuropathy (DPN). Methods Total 530 patients with type 2 diabetes were enrolled retrospectively. We rated severity of DPN from 1 (normal) to 4 (severe) based on electrophysiologic findings. We collected the data concerning vascular factors (including brachial-ankle pulse wave velocity [PWV], ankle brachial index, ultrasound of carotid artery, lipid profile from the blood test, and microalbuminuria [MU] within 24 hours urine), and metabolic factors of diabetes (such as glycated hemoglobin [HbA1c]). We analyzed the differences among the four subgroups using χ2 test and ANOVA, and ordinal logistic regression analysis was performed to investigate the relationship between significant variables and severity of DPN. Results The severity of DPN was significantly associated with duration of diabetes, HbA1c, existence of diabetic retinopathy and nephropathy, PWV, presence of plaque, low density lipoprotein-cholesterol and MU (p
