and diabetic groups. Taken together, these results suggested that AKI induced by MIR in diabetic rats may be associated with activation of the DJâ1/Nrf2 pathway ...
May 23, 2018 - pericytes are a pivotal target of complement activation leading to a ... Keywords: complement system, pericytes, ischemiaâreperfusion, ...
a Institute of Molecular Medicine, St. James's Hospital, Trinity College Dublin, Dublin 8 ... University College London, 30 Guilford Street, London, WC1N 1EH, UK.
Jun 30, 2016 - mmHg with the KHBS at 37°C and pH 7.38-7.56. The ... frozen heart was sliced from apex to base into 1-2 mm ..... Life. Sci. 2015;124:64-74.
Jun 14, 2015 - Introduction. The Golgi apparatus (GA) is a pivotal organelle in cell ..... patients with neurodegenerative diseases, such as Alzheimer's disease ...
Feb 25, 2015 - Liwei Sun, Hang Fan, Lingguang Yang, Lingling Shi and Yujun Liu * ...... Chen, H.M.; Hsu, J.H.; Liou, S.F.; Chen, T.J.; Chen, L.Y.; Chiu, C.C.; ...
The intravenous administration of ancrod, tenecteplase, reteplase, desmoteplase, urokinase, abciximab, argatroban, or other agents outside of clinical trials is ...
Nov 4, 2010 - Copyright by Medycyna Praktyczna,. Kraków 2010 ..... 2 ZakÅad Chemii Medycznej, Pomorski Uniwersytet Medyczny, Szczecin. 3 ZakÅad ...
drugs, coronary diseases and ischemia/reperfusion injury, especially in diabetic ... sion injury and how anti-platelet therapies affect post-ischemic myocardial ...
Injury: Of Mice but Not Men, a Study in Renal. IschemiaâReperfusion .... phosphate, 20 mM HEPES, 110 mM sucrose and 1 g.LÃ1 fatty acid-free bovine serum ...
May 6, 1990 - acute myocardial infarction results in improved recovery of .... lography (DATA) were performed before occlusion, during occlu- sion (at 60 min) and ... catheter over the floppy guide wire and positioned so that the proximal ...
administration of compound C before I/R abolished the activation of AMPK, diminished ... concomitant treatment with compound C abolished these responses.
Dec 16, 2016 - is anemia. Figure 3. Effect of 15 min of ischemia ..... a troublesome syndrome delineated by Cooley and his asso- ciates as âthe stone heartâ.69 ...
Jan 13, 2014 - and also found moxibustion preconditioning protects the ischemic and anoxic brain tissue by increasing the activity of endogenous antioxidase ...
Jul 24, 2015 - Domenech RJ, Sanchez G, Donoso P, Parra V, Macho P. Effect of ... Anger M, Lompre AM, Vallot O, Marotte F, Rappaport L, Samuel JL.
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was already proved by the author's group7 but using amrinone instead of olprinone. As amrinone is not avail- able to the clinical setting in Japan, it is worthwhile.
May 23, 1991 - dehydrogenase, and a more rapid release of cz-hydroxybutyrate ..... Accelerated idioventricular rhythm in persistent ischemic chest pain ...
Abstract: Ischemia and reperfusion (I/R) injury develops when blood flow is interrupted for a long period of time and then restarted. In the liver, this type of ...
Medical Center. Cardiac Functional Analysis. Cardiac function was measured in mice using the left ventricle. (LV) pressure-volume loop and echocardiography ...
Sep 1, 2015 - In sickle cell disease, recurrent vaso-occlusive crisis suppresses ... Sickle cell disease (SCD) is a worldwide distributed hereditary red cell ...
Oct 28, 2016 - hospital. Recommended reperfusion times can be achieved for STEMI patients presenting in rural areas without a nearby PCI-capable hospi-.
preconditioning on cardiomyocyte protection against ischemic- ... 2012, IP: 115.248.99.82] || Click here to download free Android application for this journal ...
[Downloaded free from http://www.ijp-online.com on Monday, January 16, 2012, IP: 115.248.99.82] || Click here to download free Android application for this journal
Research Article
Evaluation of thyroid hormone induced pharmacological preconditioning on cardiomyocyte protection against ischemicreperfusion injury Anil Kumar, Rajeev Taliyan, P.L. Sharma
ABSTRACT Objectives: Ischemic preconditioning (IPC) has been demonstrated to make myocardium transiently more resistant to deleterious effect of prolonged ischemia. The opening of the mitochondrial permeability transition pore (mPTP) at the time of myocardial reperfusion is a critical determinant of cell death. L-thyroxine pre-treatment increases the tolerance of the heart to ischemia and produces cardioprotection similar to ischemic precondition. This study has been designed to investigate the mechanism involved in L-thyroxine-induced cardiomyocyte protection against ischemia-reperfusion (I/R) injury in rats. Materials and Methods: L-thyroxine (T4) was administered to Wistar rats (n=6) (25 µg/100 g/day s.c.) for two weeks. Hearts from normal and L-thyroxine-treated rats were perfused in Langendorff’s mode and subjected to 30 min of ischemia followed by 120 min of reperfusion. Myocardial infarct size was estimated by triphenyltetrazolium chloride (TTC) staining and lactate dehydrogenase (LDH) and creatine kinase-MB (CK-MB) was analyzed in coronary effluent. Results: IPC and pharmacological preconditioning (PPC) significantly decreased (P
