Reprogramming to pluripotency is an ancient trait of ... - Nature

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Dec 11, 2012 - Natalia Tapia, Peter Reinhardt, Annett Duemmler, Guangming Wu, ... Cynthia Alexander Rascon, Akira Tazaki, Kevin Kump, Randal Voss,.
DOI: 10.1038/ncomms2458

Corrigendum: Reprogramming to pluripotency is an ancient trait of vertebrate Oct4 and Pou2 proteins Natalia Tapia, Peter Reinhardt, Annett Duemmler, Guangming Wu, Marcos J. Arau´zo-Bravo, Daniel Esch, Boris Greber, Vlad Cojocaru, Cynthia Alexander Rascon, Akira Tazaki, Kevin Kump, Randal Voss, Elly M. Tanaka & Hans R. Scho¨ler Nature Communications 3:1279 doi: 10.1038/ncomms2229 (2012); Published 11 Dec 2012; Updated 5 Feb 2013 In Fig. 1 and the first paragraph of the Discussion section in this Article, the genus Hydractinia is incorrectly referred to as hydra. The following sentence is correct: ‘Interestingly, the recently identified Pou domain gene from Hydractinia18 appears to have the features of an Oct4/Pou2 precursor gene, as shown in Fig. 1a, suggesting that the common Oct4/Pou2 ancestor could have already existed even before the specification of vertebrates.’. The correct version of Fig. 1 appears below.

a

b

1.000 0.697 0.944

0.903 Bovine (OCT4) Swine (OCT4) 0.597 Elephant (OCT4) Cat (OCT4) 0.793 Dog (OCT4) Human (OCT4) 0.661 Chimpanzee (OCT4) 0.862 Macaque (OCT4) 1.000 Mouse (OCT4) 0.948 Vole (OCT4) Rabbit (OCT4) Tammar (OCT4) Platypus (OCT4) Lizard (OCT4)

Axolotl (OCT4) 0.896 Xenopus L. (OCT25) Xenopus T. (OCT25) 0.863 0.987 1.000

1.000

0.999 0.947 0.932

0.533

0.907

0.984

Xenopus L. (OCT91) Xenopus T. (OCT91) 1.000 Tammar (POU2) Opossum (POU2)

Chicken (POU2) Axolotl (POU2) 0.547 Stickleback (POU2) 0.819 Medaka (POU2) 1.000 Cod (POU2) Zebrafish (POU2) 0.967 Carp (POU2) Hydractinia (POU)

Lg16 AxPou2

Chicken 22 kb

AxNpdc1

Zebrafish 65 kb

Bullfrog (OCT4) Xenopus L. 1.000 (OCT60) Xenopus T. (OCT60)

Platypus (POU2)

Pou2

Npdc1 Lg17 AxOct4 AxTcf19 AxCchrc1

Oct4 Tcf19

Human 12 kb Mouse 25 kb

Cchrc1 OCT4/POU2 homologue sequences

OCT6 sequences OCT1 sequences Outgroup (BRN3C zebrafish)

NATURE COMMUNICATIONS | 4:1460 | DOI: 10.1038/ncomms2458 | www.nature.com/naturecommunications

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