CASE REPORT
Synchronous Hodgkin’s lymphoma and seminoma: a rare coexistence and an important lesson Prabhsimranjot Singh1 , Sudhamshi Toom2, Makhardwaj Shrivastava1, Jason Shaw3, David Silver4, Jasminka Balderacchi5 & Jay Lipshitz1 1
Department Department 3 Department 4 Department 5 Department 2
of of of of of
Hematology/Oncology, Maimonides Medical Center, Brooklyn, New York Internal Medicine, Maimonides Medical Center, Brooklyn, New York Thoracic surgery, Maimonides Medical Center, Brooklyn, New York Urology, Maimonides Medical Center, Brooklyn, New York Pathology, Maimonides Medical Center, Brooklyn, New York
Correspondence Prabhsimranjot Singh, Department of Hematology/Oncology, Maimonides Medical Center, 950 49th street Apt 7F, Brooklyn, NY 11219. Tel: +1 646-714-9828; Fax: +1 718-635-7031; E-mail:
[email protected]
Key Clinical Message
Funding Information No sources of funding were declared for this study.
Keywords
Synchronous presentation of seminoma and lymphoma is rare but has important ramifications for the treatment of both malignancies. Without clinical vigilance, this situation may be easily missed, leading to inappropriate management. We describe a patient with synchronous seminoma and Hodgkin’s lymphoma and discuss the implication on his treatment.
Germ cell tumor, Hodgkin’s lymphoma, mediastinal lymphadenopathy, seminoma.
Received: 14 March 2017; Revised: 6 June 2017; Accepted: 24 July 2017
doi: 10.1002/ccr3.1140
Case Presentation A 59-year-old man with no significant medical history presented with progressive swelling and erythema of the right testis. Testicular cancer was suspected and he underwent a radical right inguinal orchiectomy. Pathology revealed a 5.7 cm seminoma of the testis with lymphovascular invasion and without spermatic cord involvement (pT2) (Fig. 1). His tumor markers including AFP, LDH, and Beta-HCG were normal (S0). A CT scan of the chest, abdomen, and pelvis followed by a PET/CT revealed enlarged, hypermetabolic mediastinal, hilar, and periportal lymphadenopathy interpreted by the radiologist as concerning for metastatic disease. Given the atypical distribution for lymphadenopathy from testicular seminoma, an excisional biopsy of a left hilar node was performed and revealed Classical Hodgkin’s lymphoma with IHC positive for CD15, CD30, and PAX-5 (Fig 2). He denied any Bsymptoms and his bone marrow was uninvolved by
lymphoma (stage IIIA). Adjuvant therapy for his germ cell tumor, otherwise an important consideration, was deferred, and he began chemotherapy with adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD) for six cycles. Interim PET/CT after two cycles of ABVD showed a complete response. He has completed six cycles of ABVD and chose observation as opposed to single dose of adjuvant carboplatin for his seminoma and is currently under surveillance for both malignancies.
Discussion The unusual coexistence of Hodgkin’s lymphoma and seminoma has rarely been documented in medical literature, with three other cases previously reported [1, 2]. In each case, a biopsy of lymphadenopathy, primarily outside the retroperitoneum, yielded a diagnosis of lymphoma. Both Hodgkin’s lymphoma and germ cell tumors commonly involve lymph nodes and present in young
ª 2017 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
1
P. Singh et al.
Co-existing Hodgkin’s lymphoma and germ-cell tumor
alternate diagnosis with a lymph node biopsy. A missed diagnosis of lymphoma in such a patient would also mean harmful overstaging of the germ cell tumor. These two cancers represent two of the most curable malignancies. Oncologists must therefore be extra vigilant in approaching these patients to accurately diagnose and stage them, to be able to institute appropriate therapy.
Conclusion
Figure 1. Testicular mass—Seminoma.
Our report highlights the importance of clinical suspicion of a lymphoma in patients with another cancer and lymphadenopathy not typical of metastatic disease for that tumor type. In such situations, a lymph node biopsy is crucial to proceed with the correct therapy for each malignancy. While the simultaneous presentation of Hodgkin’s lymphoma and seminoma is rare, cases like ours highlight the importance of questioning metastatic disease when lymphoma seems to be a possibility.
Authorship PS: collected data, wrote, and critically analyzed the manuscript. ST: collected data, and wrote the manuscript. MS: collected data and analyzed the manuscript. JS: critically analyzed the manuscript. DS: critically analyzed the manuscript. JB: critically analyzed the manuscript. JL: collected data and critically analyzed the manuscript.
Conflict of Interest None declared. References Figure 2. Lymph node biopsy—Classic Hodgkin’s lymphoma.
men. Lymphadenopathy may understandably be assumed to represent metastatic disease in a young man with known testicular cancer. Clinical vigilance is necessary to question the nature of atypical sites of lymphadenopathy in such a patient, and to pursue the possibility of an
2
1. Dexeus, F. H., R. Kilbourn, C. Chong, J. L. Christopher S. Avishay, and G. David. 1991. Association of germ cell tumors and Hodgkins disease. Urology 37:129–134. 2. Gerl, A., C. Clemm, C. Salat, J. Mitterm€ uller, W. Bomfleur, and W. Wilmanns. 1993. Testicular cancer and Hodgkin disease in the same patient. Cancer 71:2838–2840.
ª 2017 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.
