garding the role of A2B receptor in regulating the afferent arterioles (AA) of juxtamedullary nephron. The present study determined the role of A2B receptor in ...
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Journal of Hypertension 2008, Vol. 26 (suppl. 1)
associated with impaired endothelium-dependent vasodilation in non-treated T2DM pts. Ad may act as a link between adipose tissue and the vasculature.
PS13/THU/62 – Microvascular remodeling is associated with inflammation and oxidative stress in type 2 diabetic patients E. Shavarova, K. Isikova, N. Gudgalis, S. Villevalde, Z. Kobalava. Russian Peoples Friendship University, Moscow, Russian Federation Objectives: Type 2 diabetes mellitus (T2DM) is characterized by impaired microvascular function. Microcirculation abnormalities, inflammation and oxidative stress are implicated both in the development of T2DM and the progression of diabetic complications. The aim of the study was to evaluate the interrelation between microcirculation remodeling and inflammation and oxidative stress markers in non-treated T2DM. Methods: Microvascular function, inflammation and oxidative stress were evaluated in 84 type 2 diabetic pts (60/24 M/F, 59.0±0.8 years, BMI 30.4±0.4 kg/m2 , T2DM duration 2.6±0.2 years, fasting plasma glucose was 9.7±0.2 mmol/l, BP 139.4±1.2/77.7±1.2 mmHg). Microcirculation was assessed by laser Doppler flowmetry (LDF). Four types of microcirculation remodeling were classified according to reserve of capillary bloodflow (RCB): normocirculation (N), hyperemia (H), spasm of microvessels (SP) and stasis of blood flow (ST). Data are expressed as M ± m. Spearman univariative correlation analysis was performed. Results: Mean plasma malondialdehyde (MDA) was 40.9±1.5 μmol/l, SH groups - 298.8±8.8 μmol/l, TNF-alpha - 1.52±0.08 ng/l, IL6 - 2.24±0.21 ng/l, adiponectin (Ad) 4.2±0.2 μg/ml. Types of microvascular remodeling were the follows: N 26.2%, H 27.4%, SP 15.5%, ST 30,9%. In pts with H type of microvascular remodeling association between RCB and MDA (r=0.74; p
