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S3 Table. Top 20 significantly enriched Reactome pathways for 2,443 host genes identified in previously published RNAi screening studies. Pathway Source.

S3 Table. Top 20 significantly enriched Reactome pathways for 2,443 host genes identified in previously published RNAi screening studies.

Pathway Source

GO Term

Term P value -23

REACTOME_21.03.2014

HIV Infection

3.13×10

REACTOME_21.03.2014

HIV Life Cycle

3.38×10

REACTOME_21.03.2014

Host Interactions of HIV factors

5.20×10

REACTOME_21.03.2014

Disease

1.09×10

REACTOME_21.03.2014

Processing of Capped IntronContaining Pre-mRNA

2.25×10

REACTOME_21.03.2014

Late Phase of HIV Life Cycle

1.33×10

REACTOME_21.03.2014

Immune System

1.10×10

REACTOME_21.03.2014

Antiviral mechanism by IFNstimulated genes

7.60×10

REACTOME_21.03.2014

ISG15 antiviral mechanism

7.60×10

REACTOME_21.03.2014

Nuclear Envelope Breakdown

3.42×10

REACTOME_21.03.2014

mRNA Splicing - Minor Pathway

6.57×10

REACTOME_21.03.2014

Latent infection of Homo sapiens with Mycobacterium tuberculosis

1.08×10

REACTOME_21.03.2014

Phagosomal maturation (early endosomal stage)

1.08×10

REACTOME_21.03.2014

Nuclear Pore Complex (NPC) Disassembly

4.37×10

REACTOME_21.03.2014

Insulin receptor recycling

5.06×10

REACTOME_21.03.2014

Transcriptional Regulation of White Adipocyte Differentiation

5.44×10

-15

-14

-13

-13

-12

-11

-11

-11

-10

-10

-9

-9

-9

-9

-9

Adjust P value (Bonferroni correction) 1.57×10 1.69×10

-20

-12

2.60×10 5.42×10 1.12×10 6.63×10

-11

-11

-10

-10

5.46×10 3.76×10 3.76×10 1.69×10 3.24×10 5.31×10

5.31×10

2.15×10 2.48×10 2.66×10

-9

-8

-8

-7

-7

-7

-7

-6

-6

-6

REACTOME_21.03.2014

Activation of NF-kappaB in B Cells

7.31×10

REACTOME_21.03.2014

Regulation of mRNA Stability by Proteins that Bind AU-rich Elements

7.74×10

REACTOME_21.03.2014

Cytokine Signaling in Immune system

9.45×10

REACTOME_21.03.2014

Transport of Ribonucleoproteins into the Host Nucleus

1.55×10

-9

-9

-9

-8

3.57×10

3.77×10

4.59×10

7.51×10

-6

-6

-6

-6