Jan 25, 2014 - ... Xin Xu & Mark Y. Chan & Chi-Hang Lee & Edgar L. Tay & Adrian F. Low &. Koo Hui Chan & Winnie Sia & Liang-Qiu Tang & Huay Cheem Tan ...
Eur J Clin Pharmacol (2014) 70:527–530 DOI 10.1007/s00228-014-1650-9
CLINICAL TRIAL
Safety of combination therapy with milrinone and esmolol for heart protection during percutaneous coronary intervention in acute myocardial infarction Kian-Keong Poh & Xin Xu & Mark Y. Chan & Chi-Hang Lee & Edgar L. Tay & Adrian F. Low & Koo Hui Chan & Winnie Sia & Liang-Qiu Tang & Huay Cheem Tan & Charles Y. Lui & Vincent Nguyen & Kenichi Fujise & Ming-He Huang
Received: 10 December 2013 / Accepted: 11 January 2014 / Published online: 25 January 2014 # Springer-Verlag Berlin Heidelberg 2014
Abstract Purpose Ischemia/reperfusion injury remains an untreated clinical problem in patients with acute myocardial infarction (AMI) despite significant advances in emergent revascularization through percutaneous coronary intervention (PCI). Pharmacological intervention for infarct size reduction is unavailable. We have identified that the medications milrinone and esmolol, when administered together at the beginning of the reperfusion, significantly decrease infarct size via reducing Electronic supplementary material The online version of this article (doi:10.1007/s00228-014-1650-9 ) contains supplementary material, which is available to authorized users. K.
