Nov 2, 2014 - 1Department of Infection Control, Far Eastern Memorial Hospital, New Taipei City, Taiwan. 2Department of Internal Medicine, Far Eastern ...
Abstracts of the HIV Drug Therapy Glasgow Congress 2014 Li H-C et al. Journal of the International AIDS Society 2014, 17(Suppl 3):19736 http://www.jiasociety.org/index.php/jias/article/view/19736 | http://dx.doi.org/10.7448/IAS.17.4.19736
Poster Sessions Abstract P204
Safety, tolerability and effectiveness of HIV non-occupational prophylaxis in Taiwan Li, Hsing-Chuan1; Cheng, Yu-Ping2 and Yang, Chia-Jui2 1 Department of Infection Control, Far Eastern Memorial Hospital, New Taipei City, Taiwan. 2Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
Introduction: Increasing numbers of new HIV infection is an important issue of public health in Taiwan. We aim to evaluate the safety, tolerability and effectiveness of HIV non-occupational prophylaxis (nPEP) in Taiwan. Materials and Methods: We conducted a prospective cohort observational study between March 2011 and May 2014. Threecombined antiretroviral agents were prescribed for all the persons who sought for HIV post-exposure prophylaxis after high risk sexual behaviour. HIV screening, health education and consultation were done before initiation of nPEP. Adverse effects were evaluated at Weeks 1, 2 and 4 and effectiveness was evaluated at Weeks 12 and 24. We also assessed adherence by pill count and regimen completion rates. Results: During the study periods, 255 persons were enrolled. Among the enrolled cases, 43.9% (112/255) of them received zidovudine (AZT)-based regimen while the others received tenofovir (TDF)-based regimen and the third agent was composed of mostly lopinavir/ritonavir (81.4%). The completion rate of nPEP was 85.9% (219/255), and discontinuation rate of nPEP among AZT-based regimen is higher than TDF-based regimen (17.0% vs 8.2%). Any grade adverse effects are higher among AZT-based regimen than TDF-based regimen (62.5% vs 32.1%) although most adverse effects were grade 12. After a 24-week follow-up, only one person experienced HIV seroconversion and he had primary syphilis at the moment when he sought for nPEP. Conclusions: NPEP could be an effective prevention method in a part of HIV prevention strategy and TDF-based regimen had better tolerability in Taiwan.
Published 2 November 2014 Copyright: – 2014 Li H-C et al; licensee International AIDS Society. This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported (CC BY 3.0) License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
