Separating repeats in DNA sequence assembly* (Extended abstract ...


 



   

!"
#$
%'&)(+*-, .0/21354$6784$7:9=?3A@59CBD3FE GIHKJMLONQPSRTPSRVUWHIXKY[Z$\

`a?b+cedgf?hVc iCjlk"mnFoqplksrTkutvm0wIkujQwlxqm0ylz{k}|~ {j€z‚xqƒ0k…„†~g‡}z{kˆC‰sŠ‹~gk}ŒSlk}jŽ‡uk ~g~gk}|ylzt{~oqplk ‡}mxgxqku‡uoFxqk}‡}mjŽ~‘ogxqŽ‡…oq‚mj8mn?~gk+ŒVŽk}jl‡}k}~’oqpŽoD‡}mjl„ o“{j>xqkuwIk+oq~}”MŠ•z{m0jlƒxqkuwIk+o‡+j‡}mjln–m0ŽjŽ—>~gk}ŒSlk}jŽ‡ukoqplk€o“~gr²{jVoqm)°~gkuxq{k}~vmnsn–m0™x§~glyŽwlxqmyŽz{k}|~}› j?— ³k2—lk}~g{ƒ0j¶wlxqm0yŽyl‚z{{~‘oq{‡)oqk}~‘oq~mx-‡}m0|yŽ{j?eoqmxq‚zz{ƒ0mxqoqpŽ|~ oqpŽo§~gm0z{˜Tk°k}‡“p‹~glyŽwlxqmyŽz{k}|€”¸· pŽk‡}mxqk-~gŽyŽw™xqm0ylz‚ku|~gk}wŽ„ x“eoqk}~šxqk}wIk+oq~±Ž~g{jlƒ8oqpŽk"~gm„¹‡+z{z‚k}—QºS„¹|k+—™Ÿj§w™xqm0yŽz{k}|»{j€‡}m|8„ yl{j?oqmxq‚zKm0w™oq‚|{¼+eoq{m0j5›V³špl{‡…p>³ k±~gm0z{˜Tk~gk+ŒVŽk}jl‡}{jŽƒQkuxgxqmxx“eoqk§j?—-oqplkvk…xgxqmx x“eoqkyIk…o³ kuk}j‡}m0wl‚ku~sxqk‚—lk}jVoq{‡+zW”C·’m>m0™xCrSjŽm+³šz{k+—™ƒ0koqpl{~kuoqx p?kujSo>‡um0wŽ{k}~ jŽzt™~g{~€mnoqpŽkQn–x“ƒ0|k}jVo§~gk+ŒVŽk}jl‡}k}~§{~§xqk}ŒSlxqk+—A” Šoqkuz{tv‡}mjln–m0ŽjŽ—§~gŽ‡“p€jQwlwlxqm0‡“p5” A j?—™k}k+—•{j«oqpŽk³ mxq~‘oQ‡+~gkm0jlk°‡+jO~gpŽm+³ oqpŽo€o§‚~§‚|8„ wIm0~g~g{ylz‚k€oqm°‡}mxgxqk}‡…oqz{t²xqk}‡um0jŽ~‘ogxql‡uov°~gk+ŒVlk}jŽ‡}kvoqp?eo>‡}m0jVo“{jl~ ku¾l‡…o°‡}mwŽ{k}~-mn B< • Žmxqgk}oqŽwIjŽk+o+qk}” zt‹‚j ƒk}jŽm|‚‡²ˆs‰CŠ z{m0jlƒxqk}wIk+eoq~ xqkCz{|m0~‘o jŽk}˜Tk…x ku¾l‡…o ‡}m0wl{k}~}›™yŽloŽ~gŽz{zt>‡}m0j™„ o“{j ~g|>z{z—™œKkuxqk}jŽ‡uk}~—™‚~‘ogxq{ylloqk+—¶C4 ™oqŽp™‡“xqp m0ŽƒpŽmlo+” —lnŸ„ nÁk…xqk}jŽ‡}ku~°yIkuo†³ k}k}jµ‡um0wŽ{k}~}›³špŽ{‡“p xqk²Ž~gŽz{ztûED¨‡+–¦“z‚¥Wz{¨–k+GFª — ¨Á¦SJ ¨Áª ¬q¤¦u¢§¦q¨Á¥†¢…¦q› wIkuxq|o‚j2wlxq{jl‡}{wŽz{k§oqpŽkv‡}mxgxqk}‡uov~g~gku|8„ yŽH7Iztmn ~gH k+ŒVŽk}jl‡}k}~"k}˜Tkuj³šoqp)exqyŽogx“xq{zt°z{mjŽƒ§xqk}wIk}oq~}”8ž«pl{z‚k o8pŽ~yIkuk}jxqk}‡}mƒ0jŽ{¼}k}—2yVt°xqku~gk+xq‡“pŽkuxq~‚j)~gku˜Tkux“z wlŽylz‚{‡nÁm„ xqŽ|~eoq{‡|kuoqpŽmS—OnÁmx-‡}xgxgt™{jŽƒ•mlo~gŽ‡“p jûj?ztl~g{~-‚j‹oqpŽk)z{oqkux“oq™xqk2mjµ~gk+ŒVŽk}jl‡}k²~g~gku|yŽzt¶z{ƒ0m„ xqoqpŽ|;*¿+~ ÀlLK› S›?.™¿ ›Ž9™¿ ›?/l¿ L1› S›@V›, ?-1™¿ ).› l›!M™›@:Àl!:› 3[”2MŠmx“—™kuxšnÁmxsƒ0{˜TkujQ‡}m0jVoq{ƒl›l³ k"³ z‚rvoqpŽk}~gkso†³ mz{{~‘oq~C{j |kuxqƒk+—°mx“—™kuxoqmQ—lk…oqkuxq|{jŽkoqplkk}z{k}|k}jVo“xgt{jVoqkuxq˜0z{~mn oqpŽk z‚}tVm0™o+›IW” k”?oqpŽkz‚}tVm0™oC{jVoqkuxq˜z{~pŽ{ƒ0p ‡}me˜Tkux“ƒ0k0›loqpŽkCz‚eoqkux±wŽp?~gk}~šmn xqk}wIk+eo±~gk}w?ex“oq{m0jQ~gplm0Žz‚—§yIkz{zW”)žk€—™k}jŽmoqkvoqpl8 k _ I ® I ­{¤¥W ¨ q¢ ¬u¨Áª?©®¨[¤r­ D¨–¦“¥W¡“¨[¬ I ¥W¨[©sª a I Gª _u¥W¨[©ªyVt ‚ y ƒ-„ u €N† N -¿ O ¿ … u O L‡&€ˆ t N'ukvwxv y OzQ { |

oq{‡±jŽ—‡}m0jVo“‚j lj m€—-pŽmV‡w?x“|kuoqkuxq~>Dz{z$wŽx“|k…oqkuxq~"{jSoqk…xqj?zFoqmvoqpŽkz‚ƒm„ xqoqpl|~MpŽ+˜Tk j?eoqlx“z™{jVoqkuxqwlxqkuo“eoq{m0jŽ~$~M‡}mjlÃI—™k}jŽ‡uk yIm0ŽjŽ—l~Dm0j ³k}z{z„—™kuÃ?jlk+—§w™xqm0y?yŽ{z{oÂtvk}˜Tk}jVoq~}” A j™nÁmxq|>z{ztv³koqp™xqm0Žƒ8 8 p 1>mn oqplkwŽwIkux+›A³ kn–mxq|>z‚{¼}kk+‡“p°mn oqplk}~gk°~glyŽw™xqm0yŽz{k}|~§Ž~g{jŽƒ²oqpŽk-zŸjŽƒ?ƒkmnwlxqmy?yl{z‚o†t j?— ‡um0|yl{j?oqmxq‚zvm0wloq{|{¼+eoq‚mj5› jŽ— w™xqk}~gk}jVo²z{ƒmxqoqpŽ|~)oqp?eo ~gmz{˜TkoqpŽk}|€V” 4Sk}‡uoq{m08 j / oqpŽk}j°wlxqk}~gk}jVoq~"‡}m|wŽ™o“oq{m0jŽzDxqk}~gŽzoq~ ³šoqpQj€{|wŽz{k}|k}jVo“eoq‚mj mnFoqpŽ{~šwlwlxqm0‡“p5”

d

e

}~G€`~G

· pŽkwlxqmy?yl{z‚o†tmn myŽ~gkuxq˜S{jŽƒ  ƒ{˜Tk}j‡}me˜Tkux“ƒk—lkuwloqpQŽjŽ—lkux °jŽoqlx“zz‚zW›5oqpŽk8ku¾l‡uo w™xqm0yŽyŽ{z{oÂt {~±~g|>z{z[” ·’mm0y™o“{j>jlwŽwIkuxMyImŽj?—m0j8oqpŽk nÁz{~gk±wIm0~goq{˜TkŽwlwIkux yImŽj?—8mjvoqplkxqk}|me˜TkoqpŽk‡}m0jŽ—loq{m0jŽ{jlƒ ³k~gl|»m˜0kuxoqk}~±oqpŽksogxqlk w™xqm0yŽyŽ{z{oÂt~~exqkƒ0{˜Tkuj{[j * :S¿ 2[” O ¥ Ø°¬…¢- ¥ Jl¢¦ I £T£™©¡“¥ a}©¡°¤2¦u¢†£™¤¡‘¤¥W¨Áª H _q©0­ I ®&ª – ‹¼ŒŽ8xÇì¯í ¢…î ¤ a}¤­ ¦}¢ F{£™©¦q¨Á¥W”¨ q¢Q¦u¢†£™¤¡g¤¥W¨–ª _q©0­ ®ª © _F ˜ Jl¢£?¡‘©T¬q¤T¬u¨W­ ¨ÁR¥ b) ¥ J™¤¥p _ I ¡“¦š¨Áª€· ¤ ÆD¨Á&ª DT3© Æ2© a;ÆD`¨ D ¥ J[ß ¤&ª D^DT¢†£? ¥ J™o§¨Áªv ¥ JŽ¢CH ¤T¬q7© qI ¢C®8© DV¢u­ ¨–¦ I £T£l¢…¡ F†¬q© I &ª DV¢ D€¬ b ‚ o „àñ ƒ@º „cö ï N Ø v ß v o@OðQ { ¿x… œ¾ò ó¿ ¢ | ‚ º ƒ„ ‚ ßàsº …: … ô ~G€`õ Û µ t8÷Úø ¡ N † ¿ …úùÑ O û v Ø v @º ü v Æ0JŽ¢…¡gX ¢ UC¨Á¦ ¥ JŽ¢š¦}¢ ã I ¢…&ª _u¨–ª H ¢…¡“¡g©¡±¡g¤¥† ¢ •GS8¨Á¦ ¥ JŽÝ¢ _q©…—£ b8¢…¡“¡g©¡· ¢ _q7© q¢…¡g¤ H ¢ • t ¨Á¦± ¥ JŽc¢ _ I ® I ­{¤¥W”¨ q¢¬u¨ÁªI©®¨[¤0®­ D¨– ¦ F ¥W¡“¨[¬ I ¥W¨[©Zª a I &ª _u¥W¨[©Žª •š¿ º Q {ýéRUß;ê°¨Á¦ ¥ JŽ¢ ª I ®8¬“¢…¡€© a>¦u¢ ã I ¢…Gª _u¨Áª H þ ê-Øg܅Û}àCÔg×[×[Üu×Aå Ւí5Ù֓ݐØg×[ÔgօݹÔgÕ5Ö Þå ÕWݹå æúuÚå Õ[Ùå æú ßÖuÕ[ÔMÕ[å ݹԅâ

¢…¡“¡g©¡“¦¾—¹-o@Õ-W v ¿ º ¨Á¦¥ JŽ¢"¢…¦q¥W¨Á®¤¥†¢Dª I ®²F ¬“¢…¡©a·_“©“£?¨¹¢…¦s¨ÁªQ¥ Jl¢cÆD¨Áª&DT©3Æ5– £ k}˜0z„ ?eoqk ï N Ø v ß v o@OD{[j ´ N ½ —º OFoq{|k0”F· p™l~M³k˜z{lk ³š‚z{zI{jVogxqmS—ll‡}k nWz{~gknÁmx€ÃŽ¾™k+—°‡um0wVt Ó›M‡}mj?—loq{m0jlk+—m0j²ku¾l‡uoqzt ³“Ø ª ‡}m0wVtQk…xgxqmxq~smVƒ ‡}‡ulxq{jŽƒ ‚x j Ó”"ž°k—™kuoqkuxq|{jŽkoqpŽ{~Cw™xqm0y™„ yl{z‚o†t°ku¾l‡uoqzt-n–mx { Ø ƒ ª ›Fj?—~gpŽm+³ ƒ oqpŽ{~z‚m+³kuxyImŽjŽ—l~"oqpŽk wlxqmy?yŽ{z{{o†t³špŽku8 j Ø ª ¨ ԔßÝÕ:-Ö0z ” xqk}|me˜TkoqpŽk ‡}mj?—loq{m0jl{jŽƒ^yVtO~gl||‚jlƒ²m˜0kuxƒ z{z {j‹oqpŽ{~§x“jŽƒk0›"³špŽkuxqk jŽk}xqzt€z{zAoqplk"wlxqm0yŽyl‚z{oÂtv{~±‡}m0jlƒ ‡}k}jVogx“oqk+—K” ·’m~g~}” A j"wŽxgoq{‡}Žz‚ex+3› Ø ª „†‡um0jl΃0™x“oq{m0jl~5ƒ ‡+wloq™xqkC¤0­–­0ogxqŽk wIm0~goq{˜Tkk}˜0k}jVoq~C³špŽk}j-ƒ ku¾l‡uoqz t Ø ª ‡}mwVt-k…xgxqmxq~p?+˜Tk8mV‡u‡}lxgxqk+—K” ž«pl‚z{ko±‚~z³š‚jŽ—lm+³"›K³ k³š‚z{zF‡}m|wŽ™oqk8xqk}w™xqk}~gk}jVo“oq{˜Tk³š‚jŽ—lm+³µmn —™k}wloq»p o?ޛ o^…•¿ޛ o^…h:S›D”{”{”ŽjVoq{z³ kÎj?—Qm0jlkoqpŽos{~sn–k+~g{yŽz{k0” Š•xqk}w™xqk}~gk}jVo“oq{˜Tkš³š{j?—™me³^mn’—lk}w™oqpp o†…§º8‡}j>yIkC—™k}~g‡uxq{yIk+—yVt

ƒ

£

‹mŒŽ8$/0 ¨”q ¢…ª ¤ ¡g¢†£?ƒ ¡q¢…¦u¢…ªl¥¹¤¥W¨[©ª ©a¶¥ JŽ¢µ­ ¨Á¦q¥^© a N º v OF DÆ ¨Áª&0D ©7DÆ ¦}a ©¡º²šr›V¢Dv¤ª&D q¤¡b¨Áª ƒ •mÆ¢T_q¤ª_q©®C£ ¥†¢"¥ JŽ¢s¡q¢†£&F ƒ ¡q¢…¦u¢…ªl¥¹¤¥W¨[©ª^}a ©¡¤ª&D q ¤¡b ¨Áª H M• ¨Áªx´ N º—"O ¥¹©¥¹¤0­A¥W¨Á®>¢  • I ¦q¨Áª H ´ N ºŽO ¦[£™¤)“_ ¢– £ ŠV1 n–mxºZµ { À v ¿0›D”{”‚”t™{k}z‚—l~"j°z{ƒ0mxqoqpl| oqp?eo$Îj?—™~jvmwloq{|>zl³š‚jŽ—lm+³•{jV´ N ŠÑDO oq{|k±jŽ—p´ N ŠDO ~gw?‡uk0› jŽmo±‡}m0ljSoq{jlƒoqpŽkCoq{|kCn–mx±oqpŽksn–k+~g{yŽ{z{oÂt oqk}~‘o+›Ž³šplkuxqkXCŠ {~šoqpŽk Îxq~‘oºo³špl‚‡“pvnÁk+~g‚ylz{k8³š‚jŽ—lm+³ {~n–m0lj?—A”[™4 {jŽ‡}k³ km0jlzt

oqk}~‘oFmjŽk³š{jŽ—lm+³)nÁmxFnÁk+~g‚yl{z‚o†teoDk+‡“pºK›‡}m0ljVoq‚jlƒ±oqplk}~gk$oqku~‘oq~ 0—l—lc~ ´ N ŠK|>—¾ ¹o v ß º ¡

Ñ OCoq{|k0›5³špŽkuxq[k ߸{~oqpŽk³š‚—™oqp)mn oqpŽk m0w™oq{|>zI³š{j?—lm+³"” A j wlx“‡uoq{‡}Ýk Š›™oqplksjSŽ|yIkux mnn–x“ƒ0|k}jVoq~ ³ k p?+˜Tkxq²k Ø5…«¿>moqpŽkux ‡}mz‚l|jŽ5~ Ó Ñ Ž› Ó ƒ æ ƒ ›?”{”{”‚—› Ó Û ³šoq¡ pvoqplk±n–m0z{z{m+³š‚jlƒw™xqm0wIkuxgo†Þt Q’oqpŽkuxqk±{~ w?xˆs‰CŠ ~gk…„ ŒVŽk}jl‡}k}~šoqpŽkz{wlp?yIk…oC{~CmnM~g‚¼usk M™›?³špŽ{‡“pQ‚~C8‡}m0jl~‘o“jV o O…›Kj?— ‡+j€yIks‡}m|wŽloqk}— {j 3 N ß;o@ÑOoq{|k0” 180

A j«oqplk°~gk}‡}mj?—«w?~g~€³ k°ƒ ƒT{j‹ku¾l|‚jlk-k}‡“p‹‡}mz{Žƒ |júÓ j?—ƒ ‡}m0jl~g‚—lkux"wŽxq~smn$xqm+³š~ N v Ü OmnCoqpŽk€‡}mwŽ{k}~}› ³kC³ mŽz‚—>z‚{rTk±oqmwŽxgoqoq{m0j>oqpŽk±n–x“ƒ|k}jVoq~ {jvoqplk±³š{jŽ—lm+³O{jSoqm ‡um0wŽ{k}~yŽ~gk+—)mj2plm+³¸oqpŽkut—lœKkux>eooqplk}~gk§‡}mz{Ž|jŽ~}” A joqplk wŽxgoqoq{m0jA›sk+‡…pO‡}z‚~g~€xqkuwlxqk}~gk}jVoq~voqpŽk~gkuo€mnnŸx“ƒ|k}jVoq~ oqp?eo ~q|wŽz{k)—lœKkuxqk}jVo ‡}m0wVtmnoqpŽkQxqk}wIk}o+” ·’m²—™kuoqkuxq|{jŽk€oqplk yIku~‘o w?exgoq{oq{mj mn’oqpŽkšn–x“ƒ0|k}jVoq~ {jVoqm‡}m0wVt‡}z‚~g~gk}~ ³ ksjlk}k+—>j wŽw™xqm0wlxq‚eoqkm@y YÂk}‡uoq{˜Tksn–ŽjŽ‡…oq‚mj€m0j w?exgoq{oq{mjŽ~}” 4™lwŽwIm~gk oqpŽkvn–x“ƒ0|k}jVoq~8{j²oqpŽk ³š{jŽ—lm+³»~q|wlz‚k§º²—lœKkuxg„ kujSo‡}mwŽ{k}~mn¾™{|Ž|•nŸxqk+ŒVŽk}jl‡ut|m0jŽƒ oqplk xqm+³š~‚
j 6 >DoqpŽ{~‡}m0ljVok+ŒVŽz{^~ × NDC5v 7 O…” Ê m0|wlloq{jŽ»ƒ × Nµ¥vµ O oqpl{~v³ +t2xq€ k+—™Ž‡}k}~oqplkQwlxqm0ylz{k}| oqmw?exg€ oqoq‚mjŽ{jŽƒoqplk€xqm+³š~ mn jz‚{ƒjŽ|k}jVos{jVoqm€ºQ‡}z‚~g~gk}~}”· pl‚~"kuz‚{|{j?eoqk}~Coqplk‡}mjŽ~gk}jl~gŽ~ ~gk}ŒSlk}jŽ‡uk}~"n–xqm0|¯oqplk8nÁmxq|Žz‚oq{mj5›³špl‚‡“p|>rTk}~soqpŽkw™xqm0ylz‚ku| |Ž‡“p~g{|wŽz{kux+›™yŽ™ooqpŽkšxqk}~glz{oq{jlƒm0Ly Y‘ku‡uoq{˜Tk¢ D¨W¤ªs£?¡‘©T¬}­‚¢…®” A o’{~5r™jlm+³šjoqmšyIk ‰ ë „¹‡}m0|wlz{kuoqkšk}˜Tk}j8³šplk}j8oqpŽkšk+—™ƒ0kš³ k}{ƒ0pVoq~ exqkC"|kuogxq{‡ N ~${~ oqpŽk"‡}~gk³š{oqîp Âs||{jlƒ8—l{~‘o“jŽ‡}k}~ O…›Ij?— m0jŽztvnW{xqzt€xqku‡}k}jVoqzt p?+˜Tk ‡um0jŽ~‘o“jVog„¹nÁ‡uoqmx wŽwlxqm+¾™{|>oq{m0j>z{ƒ0mxqoqpl|~$yIk}kuj>—l{~g‡}me˜V„ kuxqk+—€n–mxCoqpl{~C~goq?eoq‚mj N ~gk}™k * 9725nÁmx8xqk}‡}k}jVÝo /„†wlwlxqm+¾™‚|>eoq{m0j z{ƒmxqoqpŽV| O…+” 4™{jŽ‡uk8³ kvxqk>Ž~g{jlƒ§oqpŽk>ºV„¹~‘o“xwlxqmyŽz{k}|¯oqm€~gk}w™„ x“eoqk§n–x“ƒ0|k}jVoq~{jVoqm°‡}mwŽ{k}~}›šj?—2jVt²me˜Tkuxqz‚w2yIkuo†³ k}k}j2oqpŽk ‡}mwSt§‡}z‚~g~gk}~Cmn$~gm0z{loq{m0jQ³š{z{zFyIk"xqk}|me˜Tk+— nŸxqm0|»oqpŽkme˜Tkuxqz‚w ƒx“wŽp³šplk}j‡}m|wŽloq{jlƒ€€z‚}tVm0™o+›Fo{~‡uxqoq‚‡}zoqpŽo³ kÃ?jŽ— jvm0w™oq{|>z?~gmz‚™oq{m0j5”Dž°k±ÃŽj?—jvm0w™oq{|>z?~gwŽjŽjl{jŽƒºS„¹~‘o“x ySt nÁmxq|lzŸeoq{jŽƒ)o ~€j•{jVoqk}ƒ0kux z{{jŽk+exg„†w™xqm0ƒx“||{jŽƒw™xqm0ylz‚ku|€› ³špŽ{‡“p§³ k"~gmz{˜Tk"yVt y™x“jl‡…p™„j?—S„†yImŽjŽ—A” L kunÁmxqk²—lk}~g‡…xq‚yl{jŽƒ²oqpŽk°y™x“jl‡…p™„j?—S„†yImŽjŽ—«z{ƒ0mxq{oqpl|³ k |>r0kmjŽkÃ?j?zsxqk}|>xqrI” iClx§—l{~g‡}Ž~g~g{mj¶Žw«oqm)oqpŽ{~€wIm{jSo p?~§~g~gŽ|k+—2oqp?ov³ krSjŽm+³ ºI›±oqplkj™l|yIkux8mn‡}m0wl{k}~}›±yŽlo oqpŽ{~±w?ex“|kuoqkux±|Ž~‘o±z{~gmyIk{jln–kuxgƒ xqk+— nŸxqm0|»oqpŽk—Žeo“™”·’m>—lk…„ oqkuxq|{jŽk8º³k>ƒT{j{j™˜0m0rTkoqpŽk8w™ƒ xq‚jl‡}{wŽz{kmn w?xq~g{|mjStV”žk o“r0k€º°oqmyIk oqpŽkv~g|>z{z{k}~‘o>˜z{Žk ³¯¿§~gl‡…p)oqpŽo8oqplk ‡}mwVt ‡}z‚~g~gku~oqpŽk€¿…„†~‘o“ex+› :e„¹~‘o“ex+—› .e„¹~‘o“xšwlxqmyŽz{k}|~}›™j?—>~gmm0jA›™ŽjVoq{z?³ kºV„¹~‘o“x ~gm„ z{loq{m0j8n–mxM³špŽ{‡“p5›T³šplk}j8³ k xqŽjoqpŽk wlxqmV‡uk+—l™xqk±mkn 4™k}‡…oq‚mpj MsnÁmx ‚—lk}jVoqn–t™{jŽƒ"~gkuw?x“eoq{jŽƒ"‡}mz‚l|jŽ~F³šoqpŽ{j8oqpŽk xqm+³š~MmnKk+‡…pmnKoq~ ‡}mwSt‡}z‚~g~gk}~}›FjŽmjŽkexqknÁmŽjŽ—A”· pl{~º{~"oqpŽkn–ku³ ku~‘ojSŽ|yIkux mn‡}m0wl{k}~"oqp?osku¾™wŽz‚{jŽ~soqplk8—lo“v³šoqplm0lo{jŽ—l{‡+oq{jlƒ nÁ™xgoqpŽkux —l{~‘oq{jŽƒŽ{~gpŽ{jlƒ yŽ~gk~goqk}~