CLINICAL RESEARCH e-ISSN 1643-3750 © Med Sci Monit, 2014; 20: 1801-1807 DOI: 10.12659/MSM.892319
Serum Annexin A2 Levels in Patients with Colon Cancer in Comparison to Healthy Controls and in Relation to Tumor Pathology
Received: 2014.08.25 Accepted: 2014.09.23 Published: 2014.10.03
Authors’ Contribution: Study Design A Data Collection B Analysis C Statistical Data Interpretation D Manuscript Preparation E Literature Search F Collection G Funds
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Ercument Gurluler Osman Serhat Guner Latif Volkan Tumay Nurten Turkel Kucukmetin Banu Hizli Abdullah Zorluoglu
1 Department of General Surgery, Acibadem University School of Medicine, Istanbul, Turkey 2 Clinic of General Surgery, Acibadem Bursa Hospital, Bursa, Turkey 3 Department of Internal Diseases, Acibadem University School of Medicine, Istanbul, Turkey 4 Department of Clinic Laboratory, Acibadem Bursa Hospital, Bursa, Turkey
Ercument Gurluler, e-mail:
[email protected] Self financing
The deregulation and localization of the Annexins is consistently reported to have close relation to tumor cell malignancy, invasion, and metastasis as well as clinical progression of tumors. This study aimed to evaluate serum Annexin A2 (Anx A2) levels in patients with colon cancer in comparison to healthy controls and in relation to demographics and tumor pathology. A total of 100 patients (mean (SD) age: 58 (5.8) years, 55.0% females) with colon cancer and 70 controls (mean (SD) age: 59 (5.4) years, 50.0% females) were included. Serum levels for Anx A2 were evaluated in relation to study group, demographics, and tumor pathology. Serum levels for Anx A2 were significantly lower in patients with colon cancer than in controls (13.1 (4.5) vs. 22.8 (2.1) ng/mL, p
