Hospital, Beijing. 7. 2. ... Department of Infectious Disease, The Third Affiliated Hospital Sun Yat-Sen. 12. University ... University, Beijing, China. 25. 11.
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Serum hepatitis B core antibody as a biomarker of hepatic inflammation in
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chronic hepatitis B patients with normal alanine aminotransferase
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Jiyuan Zhou1, Liuwei Song2, Hong Zhao1, Linlin Yan1, Anlin Ma3, Shibin Xie4, Xuqing
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Zhang5, Dazhi Zhang6, Qing Xie7, Guo Zhang8, Jia Shang9, Jun Cheng10, Weifeng
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Zhao11, Zhiqiang Zou12, Mingxiang Zhang13, Ningshao Xia2,#, Guiqiang Wang1,14,#
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1. Department of Infectious Disease, Center for Liver Disease, Peking University First
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Hospital, Beijing
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2. State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics,
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National Institute of Diagnostics and Vaccine Development in Infectious Diseases,
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School of Public Health, Xiamen University, Xiamen, China
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3. Department of Infectious Disease, China-Japan Friendship Hospital, Beijing, China
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4. Department of Infectious Disease, The Third Affiliated Hospital Sun Yat-Sen
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University, Guangzhou, Guangdong, China 5. Department of Infectious Diseases, South West Hospital affiliated to Third Military Medical University, Chongqing, China 6. Department of Infectious Diseases, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China 7. Department of Infectious Diseases, Rui Jin Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China 8. Department of Infectious Diseases, The People’s Hospital of Guang Xi Zhuang Autonomous Region, Nanning, Guangxi, China 9. Department of Infectious Diseases, The People’s Hospital of He Nan Province, Zhengzhou, Henan, China 10. Department of Infectious Diseases, Di Tan Hospital affiliated to Capital Medical University, Beijing, China 11. Department of Infectious Diseases, Xinxiang Medical University Third Hospital, Xinxiang, Henan, China 12. Department of Infectious Diseases, Yan tai City Hospital for Infectious Disease, Yan tai, Shandong, China
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13. Department of Infectious Diseases, Shenyang Sixth People’s Hospital, Shenyang, Liaoning, China 14. Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou, Zhejiang, China
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Supplementary Figure S1 Dynamic changes of liver fibrosis score in HBeAg (+)(a)
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and HBeAg (-)(b) CHB patients receiving antiviral treatment after a second liver biopsy.
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Supplementary Table S2 Univariate and multivariate analysis of clinical parameters, anti-HBc with liver inflammation in HBeAg (+) patients (n=404)
Parameters Sex distribution, males age,years BMI(kg/m2) HBsAg (log10 IU/ml) HBV DNA (log10 IU/ml) Anti-HBc (log10 IU/ml) ALT (U/L) AST (U/L) ALP (U/L) GGT (U/L) Tbil Albumin PT s PTA % INR Platelet counts (x109/L)
Univariate analysis P Value HAI ≥5 (n=249) (Univariate) HAI
