molecule-1 and E-selectin in metastatic breast carcinoma: correlations with clinicopathological features and prognosis. GUO-JUN ZHANG1'2 and ISAMU ...
INTERNATIONAL JOURNAL OF ONCOLOGY 14: 71-77, 1999
Serum levels of soluble intercellular adhesion molecule-1 and E-selectin in metastatic breast carcinoma: correlations with clinicopathological features and prognosis GUO-JUN ZHANG1'2 and ISAMU ADACHI1 Department of Medical Oncology, National Cancer Center Hospital, Tsukiji 5-1-1, Chuo-ku, Tokyo 104, Japan Received October 26, 1998; Accepted December 1, 1998
Abstract. Cellular adhesion molecules have been demonstrated to play an important role in the progression and metastasis of malignancies. We determined the serum concentrations of soluble intercellular adhesion molecule-1 (sICAM-1) and E-selectin (sE-selectin) by enzyme-linked immuno sorbent assay in 49 Japanese patients with metastatic breast cancer. Significantly high concentrations of sICAM-1 and sE-selectin were found in the patients with liver and/or bone metastases (both P60vs350 ng/ml, n=16) showed significantly poorer survival than patients with low sICAM-1 (£350 ng/ml, n=32, P=0.0019), whereas sE-selectin did not show any relationship with overall survival (P=0.312).
Multivariate analysis
Univariate analysis
1.0
0.013 0.91
95% Cl P-value
HR, hazard ratio; CI confidence interval.
pausal status, estrogen receptor status, progesterone receptor status, or lung, pleural, soft tissue, and brain metastasis. Table II. Serum concentrations of sICAM and sE-selectin and response to chemo/endocrine therapy. Response
No. o f Mean (SE) patients
Median (range) Statistics
sICAM-1 CR
6
238.7 (33.0)
231.5(150-363)
H=18.2
PR
21
323.8(22.1)
284.0 (206-606)
P=0.0004
NC
12
273.3 (39.9)
235.5(158-648)
PD
10
782.3(174.5) 600.5(265-1910)
CR
6
39.7 (3.6)
38.0 (30-52)
H=9.7
PR
21
65.0 (6.2)
60.0(21-123)
P= 0.02
NC
12
54.2 (6.8)
52.5(15-87)
PD
10
134(34.3)
126 (23-400)
sE-selectin
SE, ståndare 1 error;CR, complete response; PR, partia 1 response; NC, no change; PD, progressive disease.
Relationship between serum levels of sICAM-1, sE-selectin and IL-6. In the complete patient series, the mean concentration of IL-6 was 11.4 pg/ml (range: 0 to 146). Significant correlations were found between serum sICAM-1 and the IL-6 level (r=0.667, P=0.0001; Fig. 1A) and between sE-selectin and the IL-6 levels (r=0.642, P
