Arch Dermatol Res (2013) 305:671–672 DOI 10.1007/s00403-013-1400-3
LETTER TO THE EDITOR
Comment on ‘‘Serum methylglyoxal level and its association with oxidative stress and disease severity in patients with psoriasis’’ Ersin Aydin • Ercan Karabacak • Omer Ozcan Mustafa Dinc
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Received: 30 June 2013 / Revised: 26 July 2013 / Accepted: 30 July 2013 / Published online: 6 August 2013 Ó Springer-Verlag Berlin Heidelberg 2013
Dear Editor, We have read the article ‘‘Serum methylglyoxal level and its association with oxidative stress and disease severity in patients with psoriasis’’ written by Kaur et al. [3]. The authors aimed to compare the systemic levels of oxidative stress (OxS) markers such as total peroxide count (TPX), total antioxidant capacity (TAC), OxS index (OSI) in patients with psoriasis vulgaris (PV) and healthy controls and to investigate their correlation with the serum level of methylglyoxal (MG). They concluded that MG levels in the patients with PV were significantly increased as compared to healthy control. A significant correlation was also found between serum MG level and TPX, TAC, OSI, psoriasis area and severity index. They suggested that MG serum level, reflecting simultaneously OxS could be used as a marker of disease activity in clinical trials. Oxidative stress arises as a result of overproduction of oxygen radicals or inadequate antioxidant defense mechanisms [1]. It has received increased interest because of its pathogenesis of the disease and its complications, e.g.,
E. Aydin (&) Department of Dermatovenereology, Kasimpasa Military Hospital, Istanbul, Turkey e-mail:
[email protected] E. Karabacak Department of Dermatovenereology, GATA Haydarpasa Teaching Hospital, Istanbul, Turkey O. Ozcan Department of Biochemistry, GATA Haydarpasa Teaching Hospital, Istanbul, Turkey M. Dinc Department of Internal Medicine, Beytepe Military Hospital, Ankara, Turkey
cardiovascular disease and diabetes [3]. In recent years, OxS was proposed to be effective in etiopathogenesis of psoriasis [2, 4]. In addition, it can be impressed by other inflammatory dermatological diseases (such as irritant contact dermatitis, atopic dermatitis, acne, seborrheic dermatitis, physical urticaria, rosacea) [1, 7] and antioxidant supplements. In this point of view, in the current study, the authors did not mention whether the patients with psoriasis had other inflammatory skin diseases, usage of antioxidant supplements, which possibly affect the redox status. It would be very useful, if the authors provided information about these factors. Furthermore, increased plasma levels of MG and MGglycated proteins are the key pathogenic event in the vascular dysfunction in diabetes and hypertension [6]. Chronic hyperglycemia leads to the production of advanced glycation end products such as MG [5]. On the other hand, the fasting plasma glucose level is strongly affected by daily meals, and the measurement of glycated hemoglobin (HbA1c) is recommended as an indicator of the patient’s blood glucose state in the previous 1–2 months [5]. Therefore, in the present study, if the authors had assessed level of HbA1c instead of blood glucose level while excluding diabetes, the results would be different. After all, thanks to the authors for their valuable research which emphasizes serum MG level and disease severity in patients with psoriasis. Conflict of interest
The authors have no conflict of interest.
References 1. Emre S, Metin A, Demirseren DD, Akoglu G, Oztekin A, Neselioglu S, Erel O (2012) The association of oxidative stress
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672 and disease activity in seborrheic dermatitis. Arch Dermatol Res 304(9):683–687 2. Gabr SA, Al-Ghadir AH (2012) Role of cellular oxidative stress and cytochrome c in the pathogenesis of psoriasis. Arch Dermatol Res 304(6):451–457 3. Kaur S, Zilmer K, Leping V, Zilmer M (2013) Serum methylglyoxal level and its association with oxidative stress and disease severity in patients with psoriasis. Arch Dermatol Res 305(6):489–494 4. Kılıc S, Emre S, Metin A, Isıkoglu S, Erel O (2013) Effect of the systemic use of methotrexate on the oxidative stress and paraoxonase enzyme in psoriasis patients. Arch Dermatol Res 305(6):495–500
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Arch Dermatol Res (2013) 305:671–672 5. Kurosaki Y, Tsukushi T, Munekata S, Akahoshi T, Moriya T, Ogawa Z (2013) Semiquantitative analysis of apolipoprotein a-I modified by advanced glycation end products in diabetes mellitus. J Clin Lab Anal 27(3):231–236 6. Liu J, Wang R, Desai K, Wu L (2011) Upregulation of aldolase B and overproduction of methylglyoxal in vascular tissues from rats with metabolic syndrome. Cardiovasc Res 92(3):494–503 ¨ zdog˘an HK, Bayramgu¨rler D, C¸ekmen MB, 7. Sikar Aktu¨rk A, O Bilen N, Kıran R (2012) Nitric oxide and malondialdehyde levels in plasma and tissue of psoriasis patients. J Eur Acad Dermatol Venereol 26(7):833–837
