Serum Parathyroid Hormone Levels in Chronic ... - Springer Link
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Serum Parathyroid Hormone Levels in Chronic ... - Springer Link
Sep 14, 2010 - Mert Koroglu & AyÅe Balkarli & Siddika Ersoy &. Simge Varol & Mehmet Numan Tamer. Received: 22 May 2010 /Accepted: 6 September 2010 /.
Biol Trace Elem Res (2011) 143:79–86 DOI 10.1007/s12011-010-8847-2
Serum Parathyroid Hormone Levels in Chronic Endemic Fluorosis Banu Kale Koroglu & Ismail Hakki Ersoy & Mert Koroglu & Ayşe Balkarli & Siddika Ersoy & Simge Varol & Mehmet Numan Tamer
Received: 22 May 2010 / Accepted: 6 September 2010 / Published online: 14 September 2010 # Springer Science+Business Media, LLC 2010
Abstract Endemic waterborne fluorosis is a public health problem in Isparta, a city located in southern Turkey. Fluoride is a cumulative element that increases metabolic turnover of the bone and also affects the homeostasis of bone mineral metabolism. There are number of similarities between the effects of excess parathyroid hormone (PTH) and fluorosis on bone. So fluoride might show its effect via PTH. We aimed to determine PTH levels in patients with endemic fluorosis to estimate the possible toxic effects of chronic fluoride intake. Fifty-six patients with endemic fluorosis and 28 age-, sex-, and body-mass-indexmatched healthy controls were included in this study. Endemic fluorosis was diagnosed according to the clinical diagnosis criteria of Wang. The urine fluoride levels of fluorosis patients were significantly higher than those of control subjects as expected (1.9±0.1 vs. 0.4±0.1 mg/L, respectively; P
