Serum Phospholipases AI in Patients Undergoing ... - CiteSeerX
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Serum Phospholipases AI in Patients Undergoing ... - CiteSeerX
group II phospholipase AI increased rapidly in serum samples to maximum values on the .... man had pneumonia diagnosed on the seventh postoperative day.
Serum Phospholipases AI in Patients Undergoing Panproctocolectomy Because of Severe Ulcerative Colitis1) Markku M. Haapam ki1, Juha M. Gr nroos1, Erkki Pekkala1, Anne Jokilammi-Siltanen2, Kerttu Irjala3, Kalle Lertola4 and Timo J. Nevalainen2 1 2 3 4
Department of Surgery, University of Turku, Turku, Finland Department of Pathology, University of Turku, Turku, Finland Central Laboratory, Turku University Central Hospital, Turku, Finland Department of Statistics, University of Turku, Turku, Finland
Summary: A major role has been proposed for group II phospholipase A2 in the pathogenesis of local and generalised inflammatory reactions. Elevated catalytic activity and mass concentrations of this enzyme have been found in serum and tissue samples of the colon in patients with active ulcerative colitis. The cellular source(s) of group II phospholipase Az in the blood circulation is (are) unknown. In the current prospective study, we investigated the mass concentration of group II phospholipase AI and the catalytic activity concentration of phospholipase AI in serial serum samples of 15 consecutive patients who underwent a standard panproctocolectomy operation for severe ulcerative colitis. Both the catalytic activity concentrations of phospholipase A2 and the mass concentrations of group II phospholipase AI increased rapidly in serum samples to maximum values on the first postoperative day and then decreased (p = 0.002 and p < 0.001, respectively) in patients who recovered uneventfully. Three patients had postoperative complications that further increased the enzyme concentrations at the time of respective complications. The pattern of group II phospholipase Az mass concentration profiles was similar to the profiles of C-reactive protein. The results show that the removal of the large bowel does not eliminate the potential to secrete group II phospholipase AZ into the blood circulation in these patients. Secretion of group II phospholipase A2 into the circulation after surgery seems to be a normal host response to a major abdominal operation and postoperative complications. Consequently, we conclude that the large bowel is not an important source of group II phospholipase AZ in sera of patients with ulcerative colitis. The results also support the assumptions that the catalytic activity of phospholipase A2 in serum is attributable to group II phospholipase A2 and that this enzyme is an acute phase protein. Introduction
phospholipase Az originates from pancreatic acinar cells A22)
Phospholipase hydrolyses the fatty acyl ester bond and serves mai^ as a diSestive enz>rme· GrouP Π Phos' at the sn-2 position of glycerophospholipids. The en- PholiPase Az is found ώ several cells and tissues such zyme is widespread in bacteria, plants, snake and bee as articular cartilaSe