OBES SURG (2016) 26:1537–1548 DOI 10.1007/s11695-015-1915-0
ORIGINAL CONTRIBUTIONS
Sleeve Gastrectomy Reduces Body Weight and Improves Metabolic Profile also in Obesity-Prone Rats Rafael Moncada 1,2,4 & Sara Becerril 1,2 & Amaia Rodríguez 1,2,3 & Leire Méndez-Giménez 1,2,3 & Beatriz Ramírez 1,2,3 & Victoria Catalán 1,2,3 & Javier Gómez-Ambrosi 1,2,3 & M. Jesús Gil 1,2,5 & Secundino Fernández 1,2,6 & Javier A. Cienfuegos 1,2,7 & Víctor Valentí 1,2,7 & Gema Frühbeck 1,2,3,8
Published online: 3 October 2015 # Springer Science+Business Media New York 2015
Abstract Background Susceptibility to obesity is associated with a notable inter-individual variation. The aim of the present study was to compare the effectiveness of sleeve gastrectomy (SG) on weight loss and metabolic profile in obesity-prone (OP) rats vs animals that are non-susceptible to obesity (NSO). Methods Young male Wistar rats (n=101) were put in a dietinduced obesity (DIO) programme with ad libitum access to a high-fed diet (HFD) during 12 months. Body weight and food intake were regularly registered. Thereafter, rats were ranked by final body weight to identify the obesity-prone (OP) (n= 13) and non-susceptible to obesity (NSO) (n=14) animals. OP and NSO rats were submitted to surgical interventions (sham operation, SG and pair-fed to the amount of food eaten by Rafael Moncada and Sara Becerril contributed equally to this work. * Gema Frühbeck
[email protected] 1
CIBEROBN, Instituto de Salud Carlos III, Madrid, Spain
2
Obesity & Adipobiology Group, Instituto de Investigación Sanitario de Navarra (IdiSNA), Pamplona, Spain
3
Metabolic Research Laboratory, Clínica Universidad de Navarra, Pamplona, Spain
4
Department of Anesthesia, Clínica Universidad de Navarra, Pamplona, Spain
5
Department of Biochemistry, Clínica Universidad de Navarra, Pamplona, Spain
6
Department of Otorhinolaryngology, Clínica Universidad de Navarra, Pamplona, Spain
7
Department of Surgery, Clínica Universidad de Navarra, Pamplona, Spain
8
Department of Endocrinology & Nutrition, Clínica Universidad de Navarra, Avda. Pío XII, 36, 31008 Pamplona, Spain
sleeve-gastrectomized rats). Body weight, food intake, energy expenditure, body temperature, fat pads weight, and metabolic profiling were analysed 4 weeks after surgical or dietary interventions. Results SG in both OP and NSO rats decreased body weight as compared to sham and pair-fed groups (P
